OOSUGA Junniti 大須賀淳一

… Alternative Names

OSUGA Jun-ichi 大須賀淳一

大須賀淳一オオスガジュンイチ

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Researcher Number	10334400
Affiliation (based on the past Project Information) *help	2011 – 2013: 自治医科大学, 医学部, 准教授 2010: 自治医科大学, 医学部, 講師 2007: The University of Tokyo, Hospital, Project Lecturer 2006 – 2007: 東京大学, 医学部附属病院, 特任講師 2004: 東京大学, 医学部附属病院, 特任講師(病院) … More 2004: The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 2003: 東京大学, 医学部附属病院, 助手 2001: 東京大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Metabolomics Except Principal Investigator Metabolomics / Metabolomics
Keywords	Principal Investigator obesity / adipocyte / lipase / トリグリセリド / ホルモン感受性リパーゼ / 肥満 / 脂肪細胞 / リパーゼ / 粥状動脈硬化症 / 泡沫化 / コレステロールエステル / マクロファージ … More Except Principal Investigator … More ACAT / コレステロール / マクロファージ / 泡沫細胞 / 動脈硬化 / アポトーシス / オキシステロール / 小胞体ストレス / transcrintional regulation / triglycerides / obesity / 転写調節 / 中性脂肪 / 肥満 / hormone-sensitive lipase / adenovirus / gene targeting / atherosclerosis / コレステロールエステル / アデノウイルス / 遺伝子治療 / ホルモン感受性リパーゼ / アデノウィルス / ジーンターゲティング / エステル / 小胞体 / 脂肪酸 / 加水分解 / 酵素 / マウス / トランスジェニック / リパーゼ / NCEH1 / ERストレス / 脂質代謝異常 / 細胞死 Less

Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophages
- Principal Investigator
  
  ISHIBASHI SHUN
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Genetic analysis of molecular mechanisms of foam cell formation in atherosclerosisPrincipal Investigator
- Principal Investigator
  
  OSUGA JUN-ICHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Study on the endoplasmic stress induced by oxsterol ester and its implication to diseases
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
in vivo promoter analysis of lipogenic genes
- Principal Investigator
  
  YAHAGI Naoya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
The therapeutic application of lipolytic machinery to obesity and its related disordersPrincipal Investigator
- Principal Investigator
  
  OSUGA Jun-ichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
New therapeutic targets for atherosclerotic plaques - The role of acyl CoA : cholesterol acyltransferase and neutral cholesterol ester hydrolase in foam cell formation
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo

All 2015 2014 2013 2012 2011 2008 2006 2004 2003 Other

All Journal Article Presentation Other

[Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015
- Author(s)
  Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, Yamamuro D, Sakai K, Sekiya M, Okazaki H, Osuga J, Honda A, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 56 Issue: 5 Pages: 998-1005
- DOI
  10.1194/jlr.m057406
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014
- Author(s)
  Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, Enkhtuvshin B, Sekiya M, Okazaki H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Issue: 10 Pages: 2033-2040
- DOI
  10.1194/jlr.m047787
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014
- Author(s)
  Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Issue: 10 Pages: 2082-2092
- DOI
  10.1194/jlr.m050864
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533, KAKENHI-PROJECT-26253009
[Journal Article] Apolipoprotein C-II deficiency with no rare2013
- Author(s)
  Takase S, Osuga J, Fujita H, Hara K, Sekiya M, Igarashi M, Takanashi M,
- Journal Title
  
  J Atheroscler Thromb.
  
  Volume: 20 Pages: 481-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity2013
- Author(s)
  Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, Osuga J, Goldberg IJ, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 54(4) Issue: 4 Pages: 1124-34
- DOI
  10.1194/jlr.m035568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339, KAKENHI-PROJECT-25293213
[Journal Article] Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene2013
- Author(s)
  Takase S, Osuga J, Fujita H, Hara K, Sekiya M, Igarashi M, Takanashi M, Takeuchi Y, Izumida Y, Ohta K, Kumagai M, Nishi M, Kubota M, Masuda Y, Taira Y, Okazaki S, Iizuka Y, Yahagi N, Ohashi K, Yoshida H, Yanai H, Tada N, Gotoda T, Ishibashi S, Kadowaki T, Okazaki H
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 20(5)(Epub 2013 Mar 7) Pages: 481-93
- NAID
  130004444688
- URL
  https://www.jstage.jst.go.jp/article/jat/20/5/20_16592/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Current smoking status may be associated with overt albuminuria in female patients with type 1 diabetes mellitus: a cross-sectional study.2012
- Author(s)
  Okada K, Osuga J, Kotani K, Yagyu H, Miyamoto M, Nagasaka S, Ishibashi S.
- Journal Title
  
  Tob Induc Dis.
  
  Volume: 10 Issue: 1 Pages: 12-12
- DOI
  10.1186/1617-9625-10-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.2012
- Author(s)
  Nagashima S, Yagyu H, Ohashi K, Tazoe F, Takahashi M, Ohshiro T, Bayasgalan T, Okada K, Sekiya M, Osuga J, Ishibashi S.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 32(8) Issue: 8 Pages: 1824-31
- DOI
  10.1161/atvbaha.111.240754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339
[Journal Article] Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, decreases cholesteryl ester transfer protein in type 2 diabetes mellitus.2012
- Author(s)
  Yagyu H, Nagashima S, Takahashi M, Miyamoto M, Okada K, Osuga J, Ishibashi S.
- Journal Title
  
  Endocr J.
  
  Volume: 59 Pages: 1077-1084
- NAID
  10031146718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] The role of neutral cholesterol ester hydrolysis in macrophage foam cells2011
- Author(s)
  Sekiya M, Osuga J, Igarashi M, Okazaki H, Ishibashi S
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 18(5)(Epub 2011 Apr 6) Pages: 359-64
- NAID
  130004845376
- URL
  https://www.jstage.jst.go.jp/article/jat/18/5/18_7013/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Molecular analysis of a novel LCAT mutation (Gly179→Arg) found in a patient with complete LCAT deficiency2011
- Author(s)
  Wang XL, Osuga J, Tazoe F, Okada K, Nagashima S, Takahashi M, Ohshiro T, Bayasgalan T, Yagyu H, Okada K, Ishibashi S
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 18(8)(Epub 2011 May 20) Pages: 713-9
- NAID
  130004444539
- URL
  https://www.jstage.jst.go.jp/article/jat/18/8/18_8003/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis2008
- Author(s)
  Sekiya M, Osuga J, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice.2004
- Author(s)
  Sekiya M, Osuga J, Okazaki H, Yahagi N, Harada K, Shen WJ, Tamura Y, Tomita S, Iizuka Y, Ohashi K, Okazaki M, Sata M, Nagai R, Fujita T, Shimano H, Kraemer FB, Yamada N, Ishibashi S.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 15084-15090
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590930
[Journal Article] Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide.2004
- Author(s)
  Tamura Y, Osuga J, Adachi H, Tozawa R, Takanezawa Y, Ohashi K, Yahagi N, Sekiya M, Okazaki H, Tomita S, Iizuka Y, Koizumi H, Inaba T, Yagyu H, Kamada N, Suzuki H, Shimano H, Kadowaki T, Tsujimoto M, Arai H, Yamada N, Ishibashi S.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 30938-30944
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590930
[Journal Article] p53 involvement in the pathogenesis of fatty liver disease.2004
- Author(s)
  Yahagi N, Shimano H, Matsuzaka T, Sekiya M, Najima Y, Okazaki S, Okazaki H, Tamura Y, Iizuka Y, Inoue N, Nakagawa Y, Takeuchi Y, Ohashi K, Harada K, Gotoda T, Nagai R, Kadowaki T, Ishibashi S, Osuga J, Yamada N.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 20571-20575
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590930
[Journal Article] Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice.2003
- Author(s)
  Harada K, Shen WJ, Patel S, Natu V, Wang J, Osuga J, Ishibashi S, Kraemer FB.
- Journal Title
  
  Am J Physiol Endocrinol Metab 285
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590930
[Journal Article] Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene.2003
- Author(s)
  Ohashi K, Osuga J, Tozawa R, Kitamine T, Yagyu H, Sekiya M, Tomita S, Okazaki H, Tamura Y, Yahagi N, Iizuka Y, Harada K, Gotoda T, Shimano H, Yamada N, Ishibashi S.
- Journal Title
  
  J Biol Chem 278
  
  Pages: 42936-42941
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590930
[Journal Article] Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.2003
- Author(s)
  Sekiya M, Yahagi N, Matsuzaka T, Najima Y, Nakakuki M, Nagai R, Ishibashi S, Osuga J, Yamada N, Shimano H.
- Journal Title
  
  Hepatology 38
  
  Pages: 1529-1539
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590930
[Presentation] マクロファージ泡沫化におけるリパーゼの意義2006
- Author(s)
  大須賀淳一, 他
- Organizer
  第38回日本動脈硬化学会総会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[]
[]

1. ISHIBASHI Shun (90212919)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. YAGYU Hiroaki (60348018)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. OHASHI Ken (40376463)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. YAHAGI Naoya (60420246)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. NAGASHIMA SHUICHI (30406136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. TAKAHASHI MANABU (70406122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. YAMAMURO DAISUKE (20739255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. GOTODA Takanari (60322062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHIMANO Hitoshi (20251241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SEKIYA Motobiro (50420245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. IIZUKA Yoko (40420244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 坂井謙斗 (30646352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. HARADA Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAMURA Yoshiaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. OKAZAKI Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

OOSUGA Junniti 大須賀 淳一

OSUGA Jun-ichi 大須賀 淳一

大須賀 淳一 オオスガ ジュンイチ

Research Projects

Research Products

Co-Researchers

Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophages

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic analysis of molecular mechanisms of foam cell formation in atherosclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the endoplasmic stress induced by oxsterol ester and its implication to diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

in vivo promoter analysis of lipogenic genes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The therapeutic application of lipolytic machinery to obesity and its related disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New therapeutic targets for atherosclerotic plaques - The role of acyl CoA : cholesterol acyltransferase and neutral cholesterol ester hydrolase in foam cell formation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Apolipoprotein C-II deficiency with no rare2013

Author(s)

Journal Title

Data Source

[Journal Article] Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene2013

Author(s)

Journal Title

NAID

URL

Data Source

[Journal Article] Current smoking status may be associated with overt albuminuria in female patients with type 1 diabetes mellitus: a cross-sectional study.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.2012

Author(s)

Journal Title

OOSUGA Junniti 大須賀淳一

OSUGA Jun-ichi 大須賀淳一

大須賀淳一オオスガジュンイチ