ISHIBASHI Shun 石橋俊

… Alternative Names

石橋俊イシバシシユン

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Researcher Number	90212919
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 自治医科大学, 医学部, 客員教授 2005 – 2021: 自治医科大学, 医学部, 教授 2001: Jichi Medical University, Internal Medicine, Professor, 医学部, 教授 1996 – 2001: University of Tokyo, Faculty of Medicine, Research Associate, 医学部・附属病院, 助手 1999: 東京大学, 医学部・付属病院, 助手 … More 1999: 東京大学, 糖尿病代謝内科, 助手 1996 – 1998: 東京大学, 医学部附属病院, 助手 1997: 東京大学, 医科部・附属病院, 助手 1993 – 1995: 東京大学, 医学部(病), 助手 1989: 東京大学, 医学部(病)第三内科, 助手 Less
Review Section/Research Field	Principal Investigator Metabolomics / Metabolomics / 内分泌・代謝学 / Basic Section 54040:Metabolism and endocrinology-related / Biological Sciences Except Principal Investigator 内分泌・代謝学 / Metabolomics / Metabolomics / Digestive surgery / Chemical pharmacy / Biological Sciences
Keywords	Principal Investigator コレステロール / マクロファージ / 動脈硬化 / ノックアウトマウス / 肥満 / リパーゼ / ホルモン感受性リパーゼ / HMG-CoA還元酵素 / オキシステロール / アポトーシス … More / 糖尿病 / ジーンターゲティング / Cholesterol / ノックアウト / 肝臓 / マウス / ACAT / トランスジェニックマウス / 脂肪酸 / トリグリセリド / 細胞死 / スクアレン合成酵素 / スクワレン合成酵素 / ノックアウアトマウス / アデノウイルス / リポタンパクリパーゼ / LDLレセプター / 遺伝子治療 / 酵素 / トランスジェニック / 泡沫細胞 / 小胞体ストレス / 脂肪組織 / インスリン抵抗性 / 脂肪細胞 / 膵β細胞 / ブドウ糖 / インスリン / Bcl-2 / 酸化LDL / プラーク / アポリポタンパクE / リポタンパク / 炎症 / インスリン抵抗生 / インスリン感受性 / 低分子G蛋白 / 脂肪肝 / 遺伝子 / 動物 / 脂質 / β細胞 / ランゲルハンス島 / コレステロール合成 / グルカゴン / スタチン / liver dysfunction / knockout / mouse / albumin / liver / squalene synthase / HMG-CoA reductase / cholesterol / 細胞増殖 / ミエリン / 血管平滑筋細胞 / 肝障害 / アルブミン / IMG-CoA還元酵素 / hormone-sensitive lipase / adenovirus / gene targeting / atherosclerosis / コレステロールエステル / アデノウィルス / catecholamoine / Free fatty acids / Infertility / Triacylglycerol / Hormone-sensitive lipase / Adipocytes / Obesity / カテコラミン / 遊離脂肪酸 / 不妊 / Neural tube defect / Farneso1 / Hedgehog / Knockout mouse / Gene targeting / Squalene synthase / Development / キメラマウス / ES細胞 / ターゲティング / HMGCoA還元酵素 / 発生分化 / 神経管閉鎖不全 / ヘッジホッグ / 先天奇形 / スクワレン / Trasgenic / Knockout / Lipoprotein lipase / Apolipoprotein / Lipoprotein / Triglyceride / Atherosclerosis / 高脂血症 / 細胞間質 / レムナント / アポタンパク / asiaoglycoprotein receptor / apolipoprotein E / low density lipoprotein receptor / lipoprotein lipase / knockout mice / transgenic mice / familial hypercholesterolemia / gene therapy / コレステロール 7α-ヒドロキシラーゼ / 肝幹細胞 / Bcl2 / コレステロール7α水酸化酵素 / 相同的組換え / 移植 / シアル酸 / ガラクトース / アシアロ糖蛋白受容体 / アシアロ糖タンパクレセプター / アポリポタンパク / 家族性高コレステロール血症 / エステル / 小胞体 / 加水分解 / NCEH1 / ERストレス / 脂質代謝異常 / 摂食調節 / メタボリックシンドローム / 遺伝子発現 / ヒト / トリグリセライド / 脂肪毒性 / トリグリセライド水解酵素 / リバーゼ / トリングリセライド / メバロン酸 / ミトコンドリア / caspase 3 / CPP32 / カイロミクロンレムナント、 / トリグリセリド、 / リポタンパクリパーゼ、 / LDLレセプター、 / ノックアウトマウス、 / 動脈硬化、 / リポタンパク代謝、 / LDL受容体 / アポE … More Except Principal Investigator 動脈硬化 / atherosclerosis / マクロファージ / 脂質代謝 / インスリン抵抗性 / 糖尿病 / QTL / M-CSF / ACAT / Atheroscherosis / Molecular engineering / ノックアウトマウス / LPL / 発生工学 / リポ蛋白リパーゼ / 動脈硬化症 / 遺伝子 / アポE / Cardiomyopathy / Lipase / Steatosis / Diabetic Cardiomvonathv / 心筋症 / リパーゼ / 脂肪蓄積 / Chromosome 9 / Gene / Animal model / Insulin resistance / キヌレニン / 高血圧 / ラット / QTL解析 / SHR / 9番染色体 / モデル動物 / transcription / fatty acid / insulin resistance / SREBP / 脂肪酸 / Bcl2 (anti-apoptotic gene) / adenovirus / insulin / transplantation / pancreas / 膵臓移植 / 拒絶反応 / Bcl_2 / アデノウィルス / インスリン / アポトーシス / Bcl2 / アデノウイルス / 膵移植 / knockout mouse / hormone-sensitive lipase / obesity / ホルモン感受性リパーゼ / 肥満 / smooth / macrophage / foam cell / 平滑筋細胞 / 泡沫細胞 / Hormone-sensitive lipase / Gene targeting / コレステロール / 遺伝子ターゲティング / 分子工学 / gene therapy / LDL receptor / Apo E / ジーンターゲティング / 高脂血症 / リポタンパクリパーゼ / LDL受容体 / トランスジェニックマウス / 遺伝子治療 / LDLレセプター / 肝臓 / 粥状動脈硬化症 / 泡沫化 / コレステロールエステル / ACATアイソザイム / 医療・福祉 / ケミカルバイオロジー / ACAT アイソザイム / がん / トコフェロール / ビタミンE / 遺伝子診断 / 合併症 / リポ蛋白 / LDLレセプタ- / 神経再生 / 糖尿病性神経症 / アポリポ蛋白 Less

Elucidation of the mechanisms of alleviation of insulin resistance and hepatic steatosis by modulating cholesterol metabolism in myeloid cellsPrincipal Investigator
- Principal Investigator
  
  Ishibashi Shun
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Jichi Medical University
Diabetes mellitus induced by inhibition of cholesterol synthesis: clarification of the pathogenesis and development of its therapyPrincipal Investigator
- Principal Investigator
  
  Ishibashi Shun
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophagesPrincipal Investigator
- Principal Investigator
  
  ISHIBASHI SHUN
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
The roles of hepatic lipoprotein lipase and its regulating factors on the hepatic lipotoxicity
- Principal Investigator
  
  YAGYU Hiroaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Genetic analysis of molecular mechanisms of foam cell formation in atherosclerosis
- Principal Investigator
  
  OSUGA JUN-ICHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Study on the endoplasmic stress induced by oxsterol ester and its implication to diseasesPrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
摂食調節におけるホルモン感受性リパーゼの意義Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
脂肪細胞内lipolysisの分子機構Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Discovery and development of selectivity-defined inhibitors toward two acyl-CoA : cholesterol acyltransferase isozymes
- Principal Investigator
  
  TOMODA Hiroshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
The role of macrophage lipoprotein lipase on the development of atherosclerosis
- Principal Investigator
  
  YAGYU Hiroaki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
膵β細胞脂肪毒性解除による新規2型糖尿病治療法の開発Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in micePrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Function of hormone-sensitive lipase in the development of diabetic cardiomyopathy
- Principal Investigator
  
  SUZUKI Jinya
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  University of Fukui
ビタミンE転送蛋白質遺伝子と発ガンリスクの個体差に関する分子疫学的研究
- Principal Investigator
  
  GOTODA Takanari
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Genetic analysis of the molecular basis of insulin resistance both in animal models and in humans.
- Principal Investigator
  
  GOTODA Takanari
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Tokyo Woman's Medical University
  The University of Tokyo
New therapeutic targets for atherosclerotic plaques - The role of acyl CoA : cholesterol acyltransferase and neutral cholesterol ester hydrolase in foam cell formationPrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Roles of fatty acids in pathogenesis of insulin resisitance and atherosclerosis
- Principal Investigator
  
  YAMADA Nobuhiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Metabolomics
- Research Institution
  University of Tsukuba
Transgenic study on the heterogeneity of intacellular triacylglycerol lipasePrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Metabolomics
- Research Institution
  University of Tokyo
アポトーシスの誘導と死細胞除去におけるオキシステロールの役割Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Development of a novel animal model to investigate the role of cholesterol metabolism in the development and differentiationPrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Adenovirus-mediated anti-apoptotic gene (bcl-2) transfer in the transplant pancreas
- Principal Investigator
  
  MAKUUCHI Masatoshi, 青柳信嘉
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tokyo University
プラークの形成と破綻における泡沫細胞の細胞死の役割を解明するためのモデルの樹立Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
糖尿病性血管合併症に特異的な遺伝子マーカーの分離同定
- Principal Investigator
  
  山田信博
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokyo
Molecular biology of form cell generation in atherosclerosis
- Principal Investigator
  
  YAMADA Nobuhiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Tokyo
Study on the role of arterial retention of lipoprotein and its regulators in the development of atheroselerosisPrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Syun
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokyo
Development of animal models for atherosclerosis and obesity, and molecular mechanism of the common pathway
- Principal Investigator
  
  YAMADA Nobuhiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Tokyo
動脈硬化形成における小腸由来リポタンパクに関する発生工学的研究Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokyo
ノックアウトマウスを用いた生体内コレステロール輸送の解析Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokyo
Gene targeting study on mechanisms for cholesterol accumulation in the artery
- Principal Investigator
  
  YAMADA Nobuhiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Tokyo
Development of basic techniques for the liver-directed gene therapyPrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Tokyo
Establishment of animal models for atheroscherosis and gene therapy
- Principal Investigator
  
  YAMADA Nobuhiro
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Tokyo
糖尿病性神経症におけるアポEの役割
- Principal Investigator
  
  YAMADA Nobuhiro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokyo

[Book] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis
- Author(s)
  Sekiya, M., Osuga, JI., Yahagi, N., Okazaki, H., Tamura, Y., Igarashi, M., Takase, S., Harada, K., Okazaki, S., Iizuka, Y., Ohashi, K., Yagyu, H., Okazaki, M., Gotoda, T., Nagai, R., Kadowaki, T., Shimano, H., Yamada, N., Ishibashi, S
- Publisher
  J Lipid Res in press
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice2022
- Author(s)
  Takahashi M, Yamamuro D, Wakabayashi T, Takei A, Takei S, Nagashima S, Okazaki H, Ebihara K, Yagyu H, Takayanagi Y, Onaka T, Goldberg IJ, Ishibashi S.
- Journal Title
  
  J Biol Chem
  
  Volume: 298 Issue: 9 Pages: 102322-102322
- DOI
  10.1016/j.jbc.2022.102322
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-20K08870, KAKENHI-PROJECT-23K21443, KAKENHI-PROJECT-19H03712
[Journal Article] AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4.2022
- Author(s)
  Shibuya K, Ebihara K, Ebihara C, Sawayama N, Isoda M, Yamamuro D, Takahashi M, Nagashima S, Ishibashi S
- Journal Title
  
  J Biol Chem
  
  Volume: 298 Issue: 6 Pages: 101936-101936
- DOI
  10.1016/j.jbc.2022.101936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-20K08870, KAKENHI-PROJECT-19H03712
[Journal Article] Leptin sensitizing effect of 1,3-butanediol and its potential mechanism2021
- Author(s)
  Masayo Isoda, Ken Ebihara, Nagisa Sawayama, Akiko Murakami, Chihiro Ebihara, Koji Shibuya, Akihito Takei, Shoko Takei, Tetsuji Wakabayashi, Daisuke Yamamuro , Manabu Takahashi, Shuichi Nagashima, Shun Ishibashi
- Journal Title
  
  Sci Report
  
  Volume: 11 Issue: 1 Pages: 17691-17691
- DOI
  10.1038/s41598-021-96460-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03712, KAKENHI-PROJECT-20K08892
[Journal Article] Peripheral circadian rhythms in the liver and white adipose tissue of mice are attenuated by constant light and restored by time-restricted feeding2020
- Author(s)
  Yamamuro Daisuke、Takahashi Manabu、Nagashima Shuichi、Wakabayashi Tetsuji、Yamazaki Hisataka、Takei Akihito、Takei Shoko、Sakai Kent、Ebihara Ken、Iwasaki Yusaku、Yada Toshihiko、Ishibashi Shun
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 6 Pages: e0234439-e0234439
- DOI
  10.1371/journal.pone.0234439
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-19K22611, KAKENHI-PROJECT-19H04045, KAKENHI-PROJECT-17K09865, KAKENHI-PROJECT-19H03712
[Journal Article] β-Cell-specific deletion of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase causes overt diabetes due to reduction of β-cell mass and impaired insulin secretion.2020
- Author(s)
  Takei Shoko, Nagashima Shuichi, Takei Akihito, Yamamuro Daisuke, Wakabayashi Tetsuji, Murakami Akiko, Isoda Masayo, Yamazaki Hisataka, Ebihara Chihiro, Takahashi Manabu, Ebihara Ken, Dezaki Katsuya, Takayanagi Yuki, Onaka Tatsushi, Fujiwara Ken, Yashiro Takashi, Ishibashi Shun
- Journal Title
  
  Diabetes
  
  Volume: 69 Issue: 11 Pages: 2352-2363
- DOI
  10.2337/db19-0996
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08524, KAKENHI-PROJECT-20K07249, KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-17K08517, KAKENHI-PROJECT-17K09865, KAKENHI-PROJECT-19H03712
[Journal Article] Myeloid HMG-CoA Reductase Determines Adipose Tissue Inflammation, Insulin Resistance, and Hepatic Steatosis in Diet-Induced Obese Mice2019
- Author(s)
  Takei Akihito、Nagashima Shuichi、Takei Shoko、Yamamuro Daisuke、Murakami Akiko、Wakabayashi Tetsuji、Isoda Masayo、Yamazaki Hisataka、Ebihara Chihiro、Takahashi Manabu、Ebihara Ken、Ishibashi Shun
- Journal Title
  
  Diabetes
  
  Volume: 69 Issue: 2 Pages: 158-164
- DOI
  10.2337/db19-0076
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03712
[Journal Article] Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow2018
- Author(s)
  Wakabayashi Tetsuji、Takahashi Manabu、Yamamuro Daisuke、Karasawa Tadayoshi、Takei Akihito、Takei Shoko、Yamazaki Hisataka、Nagashima Shuichi、Ebihara Ken、Takahashi Masafumi、Ishibashi Shun
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 38 Issue: 11 Pages: 2576-2589
- DOI
  10.1161/atvbaha.118.311648
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-16K09789
[Journal Article] Myeloid HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) Reductase Determines Atherosclerosis by Modulating Migration of Macrophages2018
- Author(s)
  Sakai Kent、Nagashima Shuichi、Wakabayashi Tetsuji、Tumenbayar Bayasgalan、Hayakawa Hiroko、Hayakawa Morisada、Karasawa Tadayoshi、Ohashi Ken、Yamazaki Hisataka、Takei Akihito、Takei Shoko、Yamamuro Daisuke、Takahashi Manabu、Yagyu Hiroaki、Osuga Jun-ichi、Takahashi Masafumi、Tominaga Shin-ichi、Ishibashi Shun
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 38 Issue: 11 Pages: 2590-2600
- DOI
  10.1161/atvbaha.118.311664
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-16K09789, KAKENHI-PROJECT-17K09865
[Journal Article] Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.2015
- Author(s)
  Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Sone H, Ohashi K, Ishibashi S, Yamada N, Shimano H
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 466(3) Issue: 3 Pages: 536-540
- DOI
  10.1016/j.bbrc.2015.09.065
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15344, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-15H03093, KAKENHI-PROJECT-13J00607, KAKENHI-PROJECT-26560391, KAKENHI-PROJECT-26560392, KAKENHI-PROJECT-25293213, KAKENHI-PLANNED-23116006, KAKENHI-PROJECT-15H03092
[Journal Article] New pyripyropene derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse model.2015
- Author(s)
  Ohshiro, T.; Ohtawa, M.; Nagamitsu, T.; Matsuda, D.; Yagyu, H.; Davis, M. A.; Rudel, L. L.; Ishibashi, S.; Tomoda, H.
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 355 Issue: 2 Pages: 299-309
- DOI
  10.1124/jpet.115.227348
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26253009
[Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015
- Author(s)
  Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, Yamamuro D, Sakai K, Sekiya M, Okazaki H, Osuga J, Honda A, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 56 Issue: 5 Pages: 998-1005
- DOI
  10.1194/jlr.m057406
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014
- Author(s)
  Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, Enkhtuvshin B, Sekiya M, Okazaki H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Issue: 10 Pages: 2033-2040
- DOI
  10.1194/jlr.m047787
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014
- Author(s)
  Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Issue: 10 Pages: 2082-2092
- DOI
  10.1194/jlr.m050864
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533, KAKENHI-PROJECT-26253009
[Journal Article] Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity2013
- Author(s)
  Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, Osuga J, Goldberg IJ, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 54(4) Issue: 4 Pages: 1124-34
- DOI
  10.1194/jlr.m035568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339, KAKENHI-PROJECT-25293213
[Journal Article] Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene2013
- Author(s)
  Takase S, Osuga J, Fujita H, Hara K, Sekiya M, Igarashi M, Takanashi M, Takeuchi Y, Izumida Y, Ohta K, Kumagai M, Nishi M, Kubota M, Masuda Y, Taira Y, Okazaki S, Iizuka Y, Yahagi N, Ohashi K, Yoshida H, Yanai H, Tada N, Gotoda T, Ishibashi S, Kadowaki T, Okazaki H
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 20(5)(Epub 2013 Mar 7) Pages: 481-93
- NAID
  130004444688
- URL
  https://www.jstage.jst.go.jp/article/jat/20/5/20_16592/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Current smoking status may be associated with overt albuminuria in female patients with type 1 diabetes mellitus: a cross-sectional study.2012
- Author(s)
  Okada K, Osuga J, Kotani K, Yagyu H, Miyamoto M, Nagasaka S, Ishibashi S.
- Journal Title
  
  Tob Induc Dis.
  
  Volume: 10 Issue: 1 Pages: 12-12
- DOI
  10.1186/1617-9625-10-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.2012
- Author(s)
  Nagashima S, Yagyu H, Ohashi K, Tazoe F, Takahashi M, Ohshiro T, Bayasgalan T, Okada K, Sekiya M, Osuga J, Ishibashi S.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 32(8) Issue: 8 Pages: 1824-31
- DOI
  10.1161/atvbaha.111.240754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339
[Journal Article] Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, decreases cholesteryl ester transfer protein in type 2 diabetes mellitus.2012
- Author(s)
  Yagyu H, Nagashima S, Takahashi M, Miyamoto M, Okada K, Osuga J, Ishibashi S.
- Journal Title
  
  Endocr J.
  
  Volume: 59 Pages: 1077-1084
- NAID
  10031146718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] The role of neutral cholesterol ester hydrolysis in macrophage foam cells2011
- Author(s)
  Sekiya M, Osuga J, Igarashi M, Okazaki H, Ishibashi S
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 18(5)(Epub 2011 Apr 6) Pages: 359-64
- NAID
  130004845376
- URL
  https://www.jstage.jst.go.jp/article/jat/18/5/18_7013/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Depot-Specific Expression of Lipolytic Genes in Human Adipose Tissues.2011
- Author(s)
  Nagashima S, Yagyu H, Kurashina T, Ishibashi S, et al
- Journal Title
  
  J Atheroscler Thromb.
  
  Volume: 18 Pages: 190-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.2011
- Author(s)
  Ohta K, Yagyu H, Ishibashi S, Osuga J, et al
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 404 Pages: 254-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.2011
- Author(s)
  Ohshiro T, Matsuda D, Sakai K, Degirolamo C, Yagyu H, Rudel LL, Omura S, Ishibashi S, Tomoda H. Pyripyropene A
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 31(5) Issue: 5 Pages: 1108-15
- DOI
  10.1161/atvbaha.111.223552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187
[Journal Article] Molecular analysis of a novel LCAT mutation (Gly179→Arg) found in a patient with complete LCAT deficiency2011
- Author(s)
  Wang XL, Osuga J, Tazoe F, Okada K, Nagashima S, Takahashi M, Ohshiro T, Bayasgalan T, Yagyu H, Okada K, Ishibashi S
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 18(8)(Epub 2011 May 20) Pages: 713-9
- NAID
  130004444539
- URL
  https://www.jstage.jst.go.jp/article/jat/18/8/18_8003/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence2010
- Author(s)
  Igarashi M, Osuga J, Ishibashi S, et al
- Journal Title
  
  J Lipid Res 51
  
  Pages: 274-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.2010
- Author(s)
  Igarashi M, Osuga J, Nagashima S, Ishibashi S, et al
- Journal Title
  
  Circ Res.
  
  Volume: 107 Pages: 1387-1395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis2009
- Author(s)
  Sekiya M, Osuga J, Ishibashi S, et al
- Journal Title
  
  Cell Metab 10
  
  Pages: 219-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep(ob)(/)(ob)mice2009
- Author(s)
  Sekiya M, Yahagi H, Ishibashi S, et al
- Journal Title
  
  Biochem Biophys Res Commun 387
  
  Pages: 511-515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Induction of ABCA1 by overexpression of hormone-sensitive lipase in macrophages.2008
- Author(s)
  Tazoe F, Ishibashi S, et al
- Journal Title
  
  Biochem Biophys Res Commun 376
  
  Pages: 111-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis.2008
- Author(s)
  Sekiya M, Ishibashi S, et al
- Journal Title
  
  J Lipid Res 49
  
  Pages: 1829-1838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Leptin inhibits and ghrelin augments hypothalamicnoradrenalin release after stress.2008
- Author(s)
  Kawakami A, Ishibashi S, Onaka T, et al
- Journal Title
  
  Stress 11
  
  Pages: 363-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.2007
- Author(s)
  Usui, R., Ishibashi, S., et. al.
- Journal Title
  
  EMBO Rep 8
  
  Pages: 1155-1161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Sterol regulatory element-binding protein(SREBP) -1-independent regulation of lipogenic gene expression in adipocytes2007
- Author(s)
  Sekiya, M., Yahagi, N., Matsuzaka, T., Takeuchi, Y., Nakagawa, Y., Takahashi, H., Okazaki, H., Iizuka Y, Ohashi, K., Gotoda, T., Ishibashi, S., Nagai, R., Yamazaki, T., Kadowaki, T., Yamada, N., Osuga, JI., Shimano, H
- Journal Title
  
  J Lipid Res 48(7)
  
  Pages: 1581-1591
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Sterol regulatory element-binding protein (SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya, M., Ishibashi, S., et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-1591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18052017
[Journal Article] Sterol regulatory element-binding protein(SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya, M., Ishibashi, S., et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-1591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance.2007
- Author(s)
  Gao, J., Ishibashi, S., et. al.
- Journal Title
  
  Diabetes 56
  
  Pages: 24-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18052017
[Journal Article] Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein2007
- Author(s)
  Usui, R., Shibuya, M., Ishibashi, S., Maru, Y
- Journal Title
  
  EMBO Rep 8(12)
  
  Pages: 1155-1161
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Regulation of hormone-sensitive lipase in islets.2007
- Author(s)
  Shen, W. J., Ishibashi, S., et. al.
- Journal Title
  
  Diabetes Res Clin Pract 75
  
  Pages: 14-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659278
[Journal Article] Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.2007
- Author(s)
  Usui, R., Ishibashi, S., et. al.
- Journal Title
  
  EMBO Rep 8
  
  Pages: 1155-1161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18052017
[Journal Article] Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol : a potential role in adipocyte lipolysis.2006
- Author(s)
  Okazaki, H., Ishibashi, S., et al.
- Journal Title
  
  Diabetes 55
  
  Pages: 2091-2097
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol : a potential role in adipocyte lipolysis2006
- Author(s)
  Okazaki, H., Igarashi, M., Nishi, M., Tajima, M., Sekiya, M., Okazaki, S., Yahagi, N., Ohashi, K., Tsukamoto, K., Amemiya-Kudo, M., Matsuzaka, T., Shimano, H., Yamada, N., Aoki, J., Morikawa, R., Takanezawa, Y., Arai, H., Nagai, R., Kadowaki, T., Osuga, J., Ishibashi, S
- Journal Title
  
  Diabetes 55(7)
  
  Pages: 2091-2097
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.2006
- Author(s)
  Okazaki, H., Ishibashi, S., et al.
- Journal Title
  
  J Lipid Res 29
  
  Pages: 1950-1958
- Data Source
  KAKENHI-PROJECT-18052017
[Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.2006
- Author(s)
  Okazaki, H., Ishibashi, S., et al.
- Journal Title
  
  J Lipid Res 29
  
  Pages: 1950-1958
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.2006
- Author(s)
  Okazaki, H., Ishibashi, S., et al.
- Journal Title
  
  J Lipid Res 29
  
  Pages: 1950-1958
- Data Source
  KAKENHI-PROJECT-17659278
[Journal Article] Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol : a potential role in adipocyte lipolysis.2006
- Author(s)
  Okazaki, H., Ishibashi, S., et al.
- Journal Title
  
  Diabetes 55
  
  Pages: 2091-2097
- Data Source
  KAKENHI-PROJECT-18052017
[Journal Article] Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol : a potential role in adipocyte lipolysis.2006
- Author(s)
  Okazaki, H., Ishibashi, S., et al.
- Journal Title
  
  Diabetes 55
  
  Pages: 2091-2097
- Data Source
  KAKENHI-PROJECT-17659278
[Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver2006
- Author(s)
  Okazaki, H., Tazoe, F., Okazaki, S., Isoo, N., Tsukamoto, K., Sekiya, M., Yahagi, N., Iizuka, Y., Ohashi, K., Kitamine, T., Tozawa, R., Inaba, T., Yagyu, H., Okazaki, M., Shimano, H., Shibata, N., Arai, H., Nagai, R.Z., Kadowaki, T., Osuga, J., Ishibashi, S
- Journal Title
  
  J Lipid Res 47
  
  Pages: 1950-1958
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] High cholesterol level is essential for myelin membrane growth.2005
- Author(s)
  G.Saher, S.Ishibashi, et al.
- Journal Title
  
  Nat Neurosci 8
  
  Pages: 468-475
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.2005
- Author(s)
  M.Amemia-Kudo, S.Ishibashi, et al.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 34577-34589
- Data Source
  KAKENHI-PROJECT-17659278
[Journal Article] High cholesterol level is essential for myelin membrane growth2005
- Author(s)
  Saher, G., Brugger, B., Lappe-Siefke, C., Mobius, W., Tozawa, R., Wehr, M. C., Wieland, F., Ishibashi, S., Nave, K.A
- Journal Title
  
  Nature Neuroscience 8
  
  Pages: 468-475
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Cholesterol reduction and atherosclerosis of inhibition by bezafibrate in low density lipoprotein receptor knockout mice
- Author(s)
  Inaba, T. Yagyu, H. Itabashi, N. Tazoe, F. Fujita, N. Nagashima, S. Okada, K. Okazaki, M. Furukawa, Y. Ishibashi, S
- Journal Title
  
  Hypertens Res (in press)
- NAID
  10021935912
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] マクロファージの脂質代謝に魅せられて.2021
- Author(s)
  石橋俊:
- Organizer
  第53回日本動脈硬化学会総会,
- Invited
- Data Source
  KAKENHI-PROJECT-19H03712
[Presentation] 膵β細胞のHMG-CoA還元酵素欠損は膵β細胞の減少とインスリン分泌能の低下による糖尿病を誘発する.2021
- Author(s)
  永島秀一, 武井祥子, 武井暁一, 原一雄, 石橋俊:
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19H03712
[Presentation] コレステロール合成系と糖代謝のcross talk　組織特異的遺伝子改変マウスを用いた検討2018
- Author(s)
  永島秀一, 武井祥子, 武井暁一, 石橋俊
- Organizer
  日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09789
[Presentation] 膵β細胞特異的HMG－CoA還元酵素欠損マウスにおける糖尿病発症機序の解析2017
- Author(s)
  武井祥子，永島秀一，武井　暁一，若林徹治，山﨑久隆，山室大介，海老原千尋，高橋　学，倉科智行，海老原健，出崎克也，中田正範，大橋健，野牛宏章，矢田俊彦，屋代　隆，石橋　俊．
- Organizer
  日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09789
[Presentation] コレステロールエステル水解反応によるマクロファージ制御2015
- Author(s)
  石橋俊
- Organizer
  日本糖尿病学会年次学術集会
- Place of Presentation
  下関市民会館
- Year and Date
  2015-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-25293213
[Presentation] 動脈硬化とマクロファージ：コレステロールエステル水解機構を中心に2015
- Author(s)
  石橋俊
- Organizer
  日本動脈硬化学会年次学術集会
- Place of Presentation
  仙台国際センター
- Year and Date
  2015-07-09
- Invited
- Data Source
  KAKENHI-PROJECT-25293213
[Presentation] マクロファージ特異的リポタンパクリパーゼ欠損マウスにおける動脈硬化進展の短期及び長期的検討2009
- Author(s)
  高橋学、野牛宏晃、田副文子、永島秀一、岡田健太、宮本倫聡、大城太一、江藤一弘、石橋俊
- Organizer
  第52回糖尿病学会年次集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18590998
[Presentation] ACAT2 選択的阻害剤ピリピロペンA の抗動脈硬化作用2009
- Author(s)
  坂井謙斗、大城太一、松田大介、野牛宏晃、Lawrence Rudel、大村智、石橋俊、供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] グルコース刺激による膵β細胞内Ca^<2+>上昇のセロトニン5-HT_2B受容体アゴニストによる増強.2007
- Author(s)
  安藤明彦, 石橋俊, 他
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-17659278
[Presentation] ヒト皮下及び内臓脂肪組織における各種脂肪分解酵素の遺伝子発現と肥満・インスリン抵抗性との関連について2007
- Author(s)
  永島秀一、石橋俊、他
- Organizer
  第50回日本糖尿病学会年次総会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-18052017
[Presentation] Serotonin 2B receptor agonist BW723C86 increases cytosolic Ca<^2+> in βcells via PLC pathway and stimulates insulin and glucagons release at basal glucose in islets.2007
- Author(s)
  Ando, A., Ishibashi, S., et. al.
- Organizer
  43^<rd> Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Amsterdam
- Data Source
  KAKENHI-PROJECT-17659278
[Presentation] Depot-specific gene expression of lipolytic enzymes in human adipose tissues. Association with adiposity and plasma lipids.2007
- Author(s)
  永島秀一、石橋俊、他
- Organizer
  第67回米国糖尿病学会
- Place of Presentation
  米国シカゴ
- Data Source
  KAKENHI-PROJECT-18052017
[Presentation] 肝臓特異的スクアレン合成酵素欠損マウスにおける血清・肝臓の脂質代謝の検討2007
- Author(s)
  永島秀一、野牛宏晃、田副文子、石橋俊, 他
- Organizer
  第39回日本動脈硬化学会総会・学術集会,
- Place of Presentation
  大阪
- Year and Date
  2007-07-13
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] Lipid metabolism in liver-sepecific squalene synthase knockout mice.2007
- Author(s)
  Nagashima, S., Yagyu, H., Tazoe, F., Ishibashi, S., et. al.
- Organizer
  The 39th Annual Scientific Meeting of the Japan Atherosclerosis Society
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] Cell proliferation of vascular smooth muscle cells with defective cholesterol biosynthesis2006
- Author(s)
  Tazoe, F., Yagyu, H., Nagashima, S., Ishibashi, S., et. al.
- Organizer
  The 38th Annual Scientific Meeting of the Japan Atherosclerosis Society
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] ssential role of non-sterol pathway in the proliferation of vascular smooth muscle cells : A comparative study on the disruption of 3-hydroxy-3-Methylglutaryl coenzyme A reductase or squalene synthase2006
- Author(s)
  Tazoe, F., Yagyu, H., Itabashi, N., Ohashi, K., Tozawa, R., Inaba, T., Nagashima, S., Kato, K., Khadbaatar, Z., Osuga, J., Ishibashi, S
- Organizer
  American Heart Association Scientific Sessions 2006
- Place of Presentation
  Chicago
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
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1. YAMADA Nobuhiro (40200729)

# of Collaborated Projects: 16 results

# of Collaborated Products: 0 results
2. OOSUGA Junniti (10334400)

# of Collaborated Projects: 15 results

# of Collaborated Products: 10 results
3. HARADA Kenji

# of Collaborated Projects: 12 results

# of Collaborated Products: 0 results
4. GOTODA Takanari (60322062)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
5. NAGASHIMA Shuichi (30406136)

# of Collaborated Projects: 6 results

# of Collaborated Products: 16 results
6. YAGYU Hiroaki (60348018)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
7. SHIMANO Hitoshi (20251241)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
8. TAKAHASHI Manabu (70406122)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
9. TAZOE Fumiko (20406127)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
10. 加藤秀樹 (20406094)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. WANG Xiao li (10458325)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MAKUUCHI Masatoshi (60114641)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 板橋直樹 (00316522)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. OHASHI Ken

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. TOMODA Hiroshi (70164043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. INOKOSHI Junji (30151640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NAGAMITSU Tohru (90300756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SUNAZUKA Toshiaki (30226592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. OKAZAKI Hiroaki (80610211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YAMAMURO DAISUKE (20739255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. SONE Hirohito (30312846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TOYOSHIMA Hideo (20197966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. IWAMOTO Yasuhiko (60143434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SUZUKI Jinya (20293417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TAKAHASHI Sadao (50303376)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KOIZUMI Tsutomu (40126579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 安藤明彦 (60249315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. 坂井謙斗 (30646352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
29. 青柳信嘉 (90292903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. SHIMADA Masako

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. YAHAGI Naoya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. SHIONOIRI Futoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. MIURA Yasuaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. ABE Hideki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. SUDOH Takako

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. TAKEI shoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
37. TAKEI akihito

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
38. OHTAWA Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 高橋将文

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
40. 唐澤直義

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
41. 中川嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 出崎克也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIBASHI Shun 石橋 俊

石橋 俊 イシバシ シユン

Research Projects

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Elucidation of the mechanisms of alleviation of insulin resistance and hepatic steatosis by modulating cholesterol metabolism in myeloid cellsPrincipal Investigator

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Diabetes mellitus induced by inhibition of cholesterol synthesis: clarification of the pathogenesis and development of its therapyPrincipal Investigator

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Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophagesPrincipal Investigator

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Study on the endoplasmic stress induced by oxsterol ester and its implication to diseasesPrincipal Investigator

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摂食調節におけるホルモン感受性リパーゼの意義Principal Investigator

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脂肪細胞内lipolysisの分子機構Principal Investigator

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膵β細胞脂肪毒性解除による新規2型糖尿病治療法の開発Principal Investigator

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Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in micePrincipal Investigator

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ISHIBASHI Shun 石橋俊

石橋俊イシバシシユン