ISHIBASHI Shun 石橋俊

… Alternative Names

Researcher Number	90212919
Other IDs
Affiliation (Current)	2019: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2019: 自治医科大学, 医学部, 教授 2005 – 2017: 自治医科大学, 医学部, 教授 2001: Jichi Medical University, Internal Medicine, Professor, 医学部, 教授 1996 – 2001: University of Tokyo, Faculty of Medicine, Research Associate, 医学部・附属病院, 助手 1999: 東京大学, 医学部・付属病院, 助手 … More
Review Section/Research Field	Principal Investigator Metabolomics / Metabolomics / 内分泌・代謝学 / Basic Section 54040:Metabolism and endocrinology-related / Biological Sciences Except Principal Investigator 内分泌・代謝学 / Metabolomics / Metabolomics / Digestive surgery / Chemical pharmacy / Biological Sciences
Keywords	Principal Investigator コレステロール / マクロファージ / 動脈硬化 / ノックアウトマウス / 肥満 / ホルモン感受性リパーゼ / アポトーシス / リパーゼ / オキシステロール / 細胞死 … More Except Principal Investigator 動脈硬化 / atherosclerosis / 脂質代謝 / インスリン抵抗性 / 糖尿病 / マクロファージ / 発生工学 / LPL / ACAT / Atheroscherosis / リポ蛋白リパーゼ / Molecular engineering / QTL / M-CSF / 動脈硬化症 / アポE / 遺伝子 / ノックアウトマウス / 心筋症 / 高脂血症 / Animal model / 肥満 / トコフェロール / 医療・福祉 / トランスジェニックマウス / Bcl2 / 合併症 / LDLレセプタ- / Gene targeting / Bcl2 (anti-apoptotic gene) / Hormone-sensitive lipase / Steatosis / foam cell / 膵移植 / 遺伝子ターゲティング / 神経再生 / リポタンパクリパーゼ / obesity / アデノウィルス / 遺伝子診断 / LDLレセプター / ホルモン感受性リパーゼ / Bcl_2 / アポリポ蛋白 / Diabetic Cardiomvonathv / がん / 平滑筋細胞 / SHR / LDL受容体 / pancreas / 泡沫細胞 / ラット / ACAT アイソザイム / ジーンターゲティング / キヌレニン / insulin resistance / insulin / 脂肪酸 / 糖尿病性神経症 / アデノウイルス / Apo E / 粥状動脈硬化症 / リポ蛋白 / 遺伝子治療 / アポトーシス / リパーゼ / adenovirus / knockout mouse / Cardiomyopathy / ケミカルバイオロジー / ビタミンE / Lipase / 肝臓 / 泡沫化 / 膵臓移植 / Gene / インスリン / LDL receptor / smooth / fatty acid / hormone-sensitive lipase / 高血圧 / SREBP / 脂肪蓄積 / gene therapy / QTL解析 / 9番染色体 / コレステロール / transcription / transplantation / Chromosome 9 / 分子工学 / コレステロールエステル / モデル動物 / macrophage / Insulin resistance / ACATアイソザイム / 拒絶反応 Less

Elucidation of the mechanisms of alleviation of insulin resistance and hepatic steatosis by modulating cholesterol metabolism in myeloid cellsPrincipal InvestigatorOngoing
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Jichi Medical University
コレステロール合成阻害による糖尿病発症機構解明と治療法の開発Principal InvestigatorOngoing
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophagesPrincipal Investigator
- Principal Investigator
  
  ISHIBASHI SHUN
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
The roles of hepatic lipoprotein lipase and its regulating factors on the hepatic lipotoxicity
- Principal Investigator
  
  YAGYU Hiroaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Genetic analysis of molecular mechanisms of foam cell formation in atherosclerosis
- Principal Investigator
  
  OSUGA JUN-ICHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Study on the endoplasmic stress induced by oxsterol ester and its implication to diseasesPrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
摂食調節におけるホルモン感受性リパーゼの意義Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
脂肪細胞内lipolysisの分子機構Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Discovery and development of selectivity-defined inhibitors toward two acyl-CoA : cholesterol acyltransferase isozymes
- Principal Investigator
  
  TOMODA Hiroshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
The role of macrophage lipoprotein lipase on the development of atherosclerosis
- Principal Investigator
  
  YAGYU Hiroaki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
膵β細胞脂肪毒性解除による新規2型糖尿病治療法の開発Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in micePrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Function of hormone-sensitive lipase in the development of diabetic cardiomyopathy
- Principal Investigator
  
  SUZUKI Jinya
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  University of Fukui
ビタミンE転送蛋白質遺伝子と発ガンリスクの個体差に関する分子疫学的研究
- Principal Investigator
  
  GOTODA Takanari
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Genetic analysis of the molecular basis of insulin resistance both in animal models and in humans.
- Principal Investigator
  
  GOTODA Takanari
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Tokyo Woman's Medical University
  The University of Tokyo
New therapeutic targets for atherosclerotic plaques - The role of acyl CoA : cholesterol acyltransferase and neutral cholesterol ester hydrolase in foam cell formationPrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Roles of fatty acids in pathogenesis of insulin resisitance and atherosclerosis
- Principal Investigator
  
  YAMADA Nobuhiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Metabolomics
- Research Institution
  University of Tsukuba
Transgenic study on the heterogeneity of intacellular triacylglycerol lipasePrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Metabolomics
- Research Institution
  University of Tokyo
アポトーシスの誘導と死細胞除去におけるオキシステロールの役割Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Development of a novel animal model to investigate the role of cholesterol metabolism in the development and differentiationPrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Adenovirus-mediated anti-apoptotic gene (bcl-2) transfer in the transplant pancreas
- Principal Investigator
  
  MAKUUCHI Masatoshi, 青柳信嘉
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tokyo University
プラークの形成と破綻における泡沫細胞の細胞死の役割を解明するためのモデルの樹立Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
糖尿病性血管合併症に特異的な遺伝子マーカーの分離同定
- Principal Investigator
  
  山田信博
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokyo
Molecular biology of form cell generation in atherosclerosis
- Principal Investigator
  
  YAMADA Nobuhiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Tokyo
Study on the role of arterial retention of lipoprotein and its regulators in the development of atheroselerosisPrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Syun
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokyo
Development of animal models for atherosclerosis and obesity, and molecular mechanism of the common pathway
- Principal Investigator
  
  YAMADA Nobuhiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Tokyo
動脈硬化形成における小腸由来リポタンパクに関する発生工学的研究Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokyo
ノックアウトマウスを用いた生体内コレステロール輸送の解析Principal Investigator
- Principal Investigator
  
  石橋俊
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokyo
Gene targeting study on mechanisms for cholesterol accumulation in the artery
- Principal Investigator
  
  YAMADA Nobuhiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Tokyo
Development of basic techniques for the liver-directed gene therapyPrincipal Investigator
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Tokyo
Establishment of animal models for atheroscherosis and gene therapy
- Principal Investigator
  
  YAMADA Nobuhiro
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Tokyo
糖尿病性神経症におけるアポEの役割
- Principal Investigator
  
  YAMADA Nobuhiro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokyo

All 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis
- Author(s)
  Sekiya, M., Osuga, JI., Yahagi, N., Okazaki, H., Tamura, Y., Igarashi, M., Takase, S., Harada, K., Okazaki, S., Iizuka, Y., Ohashi, K., Yagyu, H., Okazaki, M., Gotoda, T., Nagai, R., Kadowaki, T., Shimano, H., Yamada, N., Ishibashi, S
- Publisher
  J Lipid Res in press
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy2015
- Author(s)
  Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Sone H, Ohashi K, Ishibashi S, Yamada N, Shimano H
- Journal Title
  
  Biochemical and Biophysical Research Communications.
  
  Volume: 466(3) Pages: 536-40
- DOI
  10.1016/j.bbrc.2015.09.065
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15344, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-15H03093, KAKENHI-PROJECT-13J00607, KAKENHI-PROJECT-26560391, KAKENHI-PROJECT-26560392, KAKENHI-PROJECT-25293213, KAKENHI-PLANNED-23116006, KAKENHI-PROJECT-15H03092
[Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver2015
- Author(s)
  Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, Yamamuro D, Sakai K, Sekiya M, Okazaki H, Osuga J, Honda A, Ishibashi S.
- Journal Title
  
  J Lipid Res.
  
  Volume: 56 Pages: 998-1005
- DOI
  10.1194/jlr.m057406
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870533, KAKENHI-PROJECT-25293213
[Journal Article] New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.2015
- Author(s)
  Ohshiro, T.; Ohtawa, M.; Nagamitsu, T.; Matsuda, D.; Yagyu, H.; Davis, M. A.; Rudel, L. L.; Ishibashi, S.; Tomoda, H.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 355 Pages: 299-307
- DOI
  10.1124/jpet.115.227348
- Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26253009
[Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages.2014
- Author(s)
  Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, Enkhtuvshin B, Sekiya M, Okazaki H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Pages: 2033-2040
- DOI
  10.1194/jlr.m047787
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014
- Author(s)
  Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Pages: 2082-2092
- DOI
  10.1194/jlr.m050864
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533, KAKENHI-PROJECT-26253009
[Journal Article] Macrophage lipoprotein lipase modulates the development2013
- Author(s)
  Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, Osuga J, Goldberg IJ, Ishibashi S.
- Journal Title
  
  J Lipid res
  
  Volume: 54(4) Pages: 1124-1134
- DOI
  10.1194/jlr.m035568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339, KAKENHI-PROJECT-25293213
[Journal Article] Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene2013
- Author(s)
  Takase S, Osuga J, Fujita H, Hara K, Sekiya M, Igarashi M, Takanashi M, Takeuchi Y, Izumida Y, Ohta K, Kumagai M, Nishi M, Kubota M, Masuda Y, Taira Y, Okazaki S, Iizuka Y, Yahagi N, Ohashi K, Yoshida H, Yanai H, Tada N, Gotoda T, Ishibashi S, Kadowaki T, Okazaki H
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 20(5)(Epub 2013 Mar 7) Pages: 481-93
- URL
  https://www.jstage.jst.go.jp/article/jat/20/5/20_16592/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Current smoking status may be associated with overt albuminuria in female patients with type 1 diabetes mellitus: a cross-sectional study.2012
- Author(s)
  Okada K, Osuga J, Kotani K, Yagyu H, Miyamoto M, Nagasaka S, Ishibashi S.
- Journal Title
  
  Tob Induc Dis.
  
  Volume: 10 Pages: 12-12
- DOI
  10.1186/1617-9625-10-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death2012
- Author(s)
  Nagashima S, Yagyu H, Ohashi K, Tazoe F, Takahashi M, Ohshiro T, Bayasgalan T, Okada K, Sekiya M, Osuga J, Ishibashi S.
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 32(8) Pages: 1824-1831
- DOI
  10.1161/atvbaha.111.240754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339
[Journal Article] Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, decreases cholesteryl ester transfer protein in type 2 diabetes mellitus.2012
- Author(s)
  Yagyu H, Nagashima S, Takahashi M, Miyamoto M, Okada K, Osuga J, Ishibashi S.
- Journal Title
  
  Endocr J.
  
  Volume: 59 Pages: 1077-1084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] The role of neutral cholesterol ester hydrolysis in macrophage foam cells2011
- Author(s)
  Sekiya M, Osuga J, Igarashi M, Okazaki H, Ishibashi S
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 18(5)(Epub 2011 Apr 6) Pages: 359-64
- URL
  https://www.jstage.jst.go.jp/article/jat/18/5/18_7013/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Depot-Specific Expression of Lipolytic Genes in Human Adipose Tissues.2011
- Author(s)
  Nagashima S, Yagyu H, Kurashina T, Ishibashi S, et al
- Journal Title
  
  J Atheroscler Thromb.
  
  Volume: 18 Pages: 190-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.2011
- Author(s)
  Ohta K, Yagyu H, Ishibashi S, Osuga J, et al
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 404 Pages: 254-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.2011
- Author(s)
  Ohshiro T, Matsuda D, Sakai K, Degirolamo C, Yagyu H, Rudel LL, Omura S, Ishibashi S, Tomoda H. Pyripyropene A
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 31(5) Pages: 1108-15
- DOI
  10.1161/atvbaha.111.223552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187
[Journal Article] Molecular analysis of a novel LCAT mutation (Gly179→Arg) found in a patient with complete LCAT deficiency2011
- Author(s)
  Wang XL, Osuga J, Tazoe F, Okada K, Nagashima S, Takahashi M, Ohshiro T, Bayasgalan T, Yagyu H, Okada K, Ishibashi S
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 18(8)(Epub 2011 May 20) Pages: 713-9
- URL
  https://www.jstage.jst.go.jp/article/jat/18/8/18_8003/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.2011
- Author(s)
  Ohta K, Sekiya M, Uozaki H, Igarashi M, Takase S, Kumagai M, Takanashi M, Takeuchi Y, Izumida Y, Kubota M, Nishi M, Okazaki H, Iizuka Y, Yahagi N, Yagyu H, Fukayama M, Kadowaki T, Ohashi K, Ishibashi S, Osuga JI
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 404 Pages: 254-260
- DOI
  10.1016/j.bbrc.2010.11.103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591123, KAKENHI-PROJECT-22390187, KAKENHI-PLANNED-23116006, KAKENHI-PROJECT-23591339
[Journal Article] The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.2010
- Author(s)
  Igarashi M, Kadowaki T
- Journal Title
  
  Circ Res.
  
  Volume: 107 Pages: 1387-1395
- DOI
  10.1161/circresaha.110.226613
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-22390187
[Journal Article] Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence2010
- Author(s)
  Igarashi M, Osuga J, Ishibashi S, et al
- Journal Title
  
  J Lipid Res 51
  
  Pages: 274-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.2010
- Author(s)
  Igarashi M, Osuga J, Nagashima S, Ishibashi S, et al
- Journal Title
  
  Circ Res.
  
  Volume: 107 Pages: 1387-1395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis2009
- Author(s)
  Sekiya M, Osuga J, Ishibashi S, et al
- Journal Title
  
  Cell Metab 10
  
  Pages: 219-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep(ob)(/)(ob)mice2009
- Author(s)
  Sekiya M, Yahagi H, Ishibashi S, et al
- Journal Title
  
  Biochem Biophys Res Commun 387
  
  Pages: 511-515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Induction of ABCA1 by overexpression of hormone-sensitive lipase in macrophages.2008
- Author(s)
  Tazoe F, Ishibashi S, et al
- Journal Title
  
  Biochem Biophys Res Commun 376
  
  Pages: 111-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis.2008
- Author(s)
  Sekiya M, Ishibashi S, et al
- Journal Title
  
  J Lipid Res 49
  
  Pages: 1829-1838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Leptin inhibits and ghrelin augments hypothalamicnoradrenalin release after stress.2008
- Author(s)
  Kawakami A, Ishibashi S, Onaka T, et al
- Journal Title
  
  Stress 11
  
  Pages: 363-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659147
[Journal Article] Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.2007
- Author(s)
  Usui, R., Ishibashi, S., et. al.
- Journal Title
  
  EMBO Rep 8
  
  Pages: 1155-1161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Sterol regulatory element-binding protein(SREBP) -1-independent regulation of lipogenic gene expression in adipocytes2007
- Author(s)
  Sekiya, M., Yahagi, N., Matsuzaka, T., Takeuchi, Y., Nakagawa, Y., Takahashi, H., Okazaki, H., Iizuka Y, Ohashi, K., Gotoda, T., Ishibashi, S., Nagai, R., Yamazaki, T., Kadowaki, T., Yamada, N., Osuga, JI., Shimano, H
- Journal Title
  
  J Lipid Res 48(7)
  
  Pages: 1581-1591
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Sterol regulatory element-binding protein (SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya, M., Ishibashi, S., et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-1591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18052017
[Journal Article] Sterol regulatory element-binding protein(SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya, M., Ishibashi, S., et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-1591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance.2007
- Author(s)
  Gao, J., Ishibashi, S., et. al.
- Journal Title
  
  Diabetes 56
  
  Pages: 24-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18052017
[Journal Article] Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein2007
- Author(s)
  Usui, R., Shibuya, M., Ishibashi, S., Maru, Y
- Journal Title
  
  EMBO Rep 8(12)
  
  Pages: 1155-1161
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Regulation of hormone-sensitive lipase in islets.2007
- Author(s)
  Shen, W. J., Ishibashi, S., et. al.
- Journal Title
  
  Diabetes Res Clin Pract 75
  
  Pages: 14-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659278
[Journal Article] Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.2007
- Author(s)
  Usui, R., Ishibashi, S., et. al.
- Journal Title
  
  EMBO Rep 8
  
  Pages: 1155-1161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18052017
[Journal Article] Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol : a potential role in adipocyte lipolysis.2006
- Author(s)
  Okazaki, H., Ishibashi, S., et al.
- Journal Title
  
  Diabetes 55
  
  Pages: 2091-2097
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol : a potential role in adipocyte lipolysis2006
- Author(s)
  Okazaki, H., Igarashi, M., Nishi, M., Tajima, M., Sekiya, M., Okazaki, S., Yahagi, N., Ohashi, K., Tsukamoto, K., Amemiya-Kudo, M., Matsuzaka, T., Shimano, H., Yamada, N., Aoki, J., Morikawa, R., Takanezawa, Y., Arai, H., Nagai, R., Kadowaki, T., Osuga, J., Ishibashi, S
- Journal Title
  
  Diabetes 55(7)
  
  Pages: 2091-2097
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.2006
- Author(s)
  Okazaki, H., Ishibashi, S., et al.
- Journal Title
  
  J Lipid Res 29
  
  Pages: 1950-1958
- Data Source
  KAKENHI-PROJECT-18052017
[Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.2006
- Author(s)
  Okazaki, H., Ishibashi, S., et al.
- Journal Title
  
  J Lipid Res 29
  
  Pages: 1950-1958
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.2006
- Author(s)
  Okazaki, H., Ishibashi, S., et al.
- Journal Title
  
  J Lipid Res 29
  
  Pages: 1950-1958
- Data Source
  KAKENHI-PROJECT-17659278
[Journal Article] Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol : a potential role in adipocyte lipolysis.2006
- Author(s)
  Okazaki, H., Ishibashi, S., et al.
- Journal Title
  
  Diabetes 55
  
  Pages: 2091-2097
- Data Source
  KAKENHI-PROJECT-18052017
[Journal Article] Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol : a potential role in adipocyte lipolysis.2006
- Author(s)
  Okazaki, H., Ishibashi, S., et al.
- Journal Title
  
  Diabetes 55
  
  Pages: 2091-2097
- Data Source
  KAKENHI-PROJECT-17659278
[Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver2006
- Author(s)
  Okazaki, H., Tazoe, F., Okazaki, S., Isoo, N., Tsukamoto, K., Sekiya, M., Yahagi, N., Iizuka, Y., Ohashi, K., Kitamine, T., Tozawa, R., Inaba, T., Yagyu, H., Okazaki, M., Shimano, H., Shibata, N., Arai, H., Nagai, R.Z., Kadowaki, T., Osuga, J., Ishibashi, S
- Journal Title
  
  J Lipid Res 47
  
  Pages: 1950-1958
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] High cholesterol level is essential for myelin membrane growth.2005
- Author(s)
  G.Saher, S.Ishibashi, et al.
- Journal Title
  
  Nat Neurosci 8
  
  Pages: 468-475
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.2005
- Author(s)
  M.Amemia-Kudo, S.Ishibashi, et al.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 34577-34589
- Data Source
  KAKENHI-PROJECT-17659278
[Journal Article] High cholesterol level is essential for myelin membrane growth2005
- Author(s)
  Saher, G., Brugger, B., Lappe-Siefke, C., Mobius, W., Tozawa, R., Wehr, M. C., Wieland, F., Ishibashi, S., Nave, K.A
- Journal Title
  
  Nature Neuroscience 8
  
  Pages: 468-475
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Cholesterol reduction and atherosclerosis of inhibition by bezafibrate in low density lipoprotein receptor knockout mice
- Author(s)
  Inaba, T. Yagyu, H. Itabashi, N. Tazoe, F. Fujita, N. Nagashima, S. Okada, K. Okazaki, M. Furukawa, Y. Ishibashi, S
- Journal Title
  
  Hypertens Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] 膵β細胞特異的HMG－CoA還元酵素欠損マウスにおける糖尿病発症機序の解析2017
- Author(s)
  武井祥子，永島秀一，武井　暁一，若林徹治，山﨑久隆，山室大介，海老原千尋，高橋　学，倉科智行，海老原健，出崎克也，中田正範，大橋健，野牛宏章，矢田俊彦，屋代　隆，石橋　俊．
- Organizer
  日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09789
[Presentation] コレステロールエステル水解反応によるマクロファージ制御2015
- Author(s)
  石橋俊
- Organizer
  日本糖尿病学会年次学術集会
- Place of Presentation
  下関市民会館
- Year and Date
  2015-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-25293213
[Presentation] 動脈硬化とマクロファージ：コレステロールエステル水解機構を中心に2015
- Author(s)
  石橋俊
- Organizer
  日本動脈硬化学会年次学術集会
- Place of Presentation
  仙台国際センター
- Year and Date
  2015-07-09
- Invited
- Data Source
  KAKENHI-PROJECT-25293213
[Presentation] マクロファージ特異的リポタンパクリパーゼ欠損マウスにおける動脈硬化進展の短期及び長期的検討2009
- Author(s)
  高橋学、野牛宏晃、田副文子、永島秀一、岡田健太、宮本倫聡、大城太一、江藤一弘、石橋俊
- Organizer
  第52回糖尿病学会年次集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18590998
[Presentation] ACAT2 選択的阻害剤ピリピロペンA の抗動脈硬化作用2009
- Author(s)
  坂井謙斗、大城太一、松田大介、野牛宏晃、Lawrence Rudel、大村智、石橋俊、供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] グルコース刺激による膵β細胞内Ca^<2+>上昇のセロトニン5-HT_2B受容体アゴニストによる増強.2007
- Author(s)
  安藤明彦, 石橋俊, 他
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-17659278
[Presentation] ヒト皮下及び内臓脂肪組織における各種脂肪分解酵素の遺伝子発現と肥満・インスリン抵抗性との関連について2007
- Author(s)
  永島秀一、石橋俊、他
- Organizer
  第50回日本糖尿病学会年次総会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-18052017
[Presentation] Serotonin 2B receptor agonist BW723C86 increases cytosolic Ca<^2+> in βcells via PLC pathway and stimulates insulin and glucagons release at basal glucose in islets.2007
- Author(s)
  Ando, A., Ishibashi, S., et. al.
- Organizer
  43^<rd> Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Amsterdam
- Data Source
  KAKENHI-PROJECT-17659278
[Presentation] Depot-specific gene expression of lipolytic enzymes in human adipose tissues. Association with adiposity and plasma lipids.2007
- Author(s)
  永島秀一、石橋俊、他
- Organizer
  第67回米国糖尿病学会
- Place of Presentation
  米国シカゴ
- Data Source
  KAKENHI-PROJECT-18052017
[Presentation] 肝臓特異的スクアレン合成酵素欠損マウスにおける血清・肝臓の脂質代謝の検討2007
- Author(s)
  永島秀一、野牛宏晃、田副文子、石橋俊, 他
- Organizer
  第39回日本動脈硬化学会総会・学術集会,
- Place of Presentation
  大阪
- Year and Date
  2007-07-13
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] Lipid metabolism in liver-sepecific squalene synthase knockout mice.2007
- Author(s)
  Nagashima, S., Yagyu, H., Tazoe, F., Ishibashi, S., et. al.
- Organizer
  The 39th Annual Scientific Meeting of the Japan Atherosclerosis Society
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] Cell proliferation of vascular smooth muscle cells with defective cholesterol biosynthesis2006
- Author(s)
  Tazoe, F., Yagyu, H., Nagashima, S., Ishibashi, S., et. al.
- Organizer
  The 38th Annual Scientific Meeting of the Japan Atherosclerosis Society
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] ssential role of non-sterol pathway in the proliferation of vascular smooth muscle cells : A comparative study on the disruption of 3-hydroxy-3-Methylglutaryl coenzyme A reductase or squalene synthase2006
- Author(s)
  Tazoe, F., Yagyu, H., Itabashi, N., Ohashi, K., Tozawa, R., Inaba, T., Nagashima, S., Kato, K., Khadbaatar, Z., Osuga, J., Ishibashi, S
- Organizer
  American Heart Association Scientific Sessions 2006
- Place of Presentation
  Chicago
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266

1. YAMADA Nobuhiro (40200729)

# of Collaborated Projects: 16 results

# of Collaborated Products: 0 results
2. OOSUGA Junniti (10334400)

# of Collaborated Projects: 15 results

# of Collaborated Products: 12 results
3. HARADA Kenji

# of Collaborated Projects: 12 results

# of Collaborated Products: 0 results
4. GOTODA Takanari (60322062)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
5. YAGYU Hiroaki (60348018)

# of Collaborated Projects: 6 results

# of Collaborated Products: 16 results
6. SHIMANO Hitoshi (20251241)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
7. NAGASHIMA Shuichi (30406136)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
8. TAKAHASHI Manabu (70406122)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
9. TAZOE Fumiko (20406127)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
10. 加藤秀樹 (20406094)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. WANG Xiao li (10458325)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MAKUUCHI Masatoshi (60114641)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 板橋直樹 (00316522)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. OHASHI Ken

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. TOMODA Hiroshi (70164043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. INOKOSHI Junji (30151640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NAGAMITSU Tohru (90300756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SUNAZUKA Toshiaki (30226592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. OKAZAKI Hiroaki (80610211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YAMAMURO DAISUKE (20739255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. SONE Hirohito (30312846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TOYOSHIMA Hideo (20197966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. IWAMOTO Yasuhiko (60143434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SUZUKI Jinya (20293417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TAKAHASHI Sadao (50303376)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KOIZUMI Tsutomu (40126579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 安藤明彦 (60249315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. 坂井謙斗 (30646352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 青柳信嘉 (90292903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. SHIMADA Masako

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. YAHAGI Naoya

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
32. SHIONOIRI Futoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. MIURA Yasuaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. ABE Hideki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. SUDOH Takako

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. OHTAWA Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 門脇孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 中川嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 松坂賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIBASHI Shun 石橋 俊

石橋 俊 イシバシ シユン

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Co-Researchers

Elucidation of the mechanisms of alleviation of insulin resistance and hepatic steatosis by modulating cholesterol metabolism in myeloid cellsPrincipal InvestigatorOngoing

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コレステロール合成阻害による糖尿病発症機構解明と治療法の開発Principal InvestigatorOngoing

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Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophagesPrincipal Investigator

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Study on the endoplasmic stress induced by oxsterol ester and its implication to diseasesPrincipal Investigator

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摂食調節におけるホルモン感受性リパーゼの意義Principal Investigator

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脂肪細胞内lipolysisの分子機構Principal Investigator

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膵β細胞脂肪毒性解除による新規2型糖尿病治療法の開発Principal Investigator

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Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in micePrincipal Investigator

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ISHIBASHI Shun 石橋俊

石橋俊イシバシシユン