Tomoda Hiroshi 供田洋

… Alternative Names

Researcher Number	70164043
Other IDs
External Links
Affiliation (Current)	2019: 北里大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2014 – 2018: 北里大学, 薬学部, 教授 2005 – 2012: 北里大学, 薬学部, 教授 2001 – 2004: 北里大学, 北里生命科学研究所, 教授 2003: 北里大学, 生命科学研究所, 教授 1999: 社団法人北里研究所, 生物機能研究所, 副所長 … More
Review Section/Research Field	Principal Investigator Natural medicines / Medium-sized Section 47:Pharmaceutical sciences and related fields / Chemical pharmacy / Science and Engineering / Living organism molecular science / Bioorganic chemistry Except Principal Investigator Biological pharmacy / Chemical pharmacy / Chemical pharmacy / Conservation of biological resources / 応用微生物学 / Biomolecular chemistry
Keywords	Principal Investigator 脂質代謝 / 循環器・高血圧 / 感染症 / 医療・福祉 / CETP / 阻害剤 / ケミカルバイオロジー / マルチカッパーオキシダーゼ / ACAT アイソザイム / マルチ銅オキシダーゼ … More Except Principal Investigator ACAT / 阻害剤 / CETP / HDL / LDL / ピリピロペン / マクロファージ / 誘導体合成 / Inhibitor / コレステロール / コレステロール代謝阻害剤 / 変性LDL / 生態系保全 / カエルツボカビ / 海綿 / 構造活性相関 / Catalase / Biosynthesis / chemistry of natural products / synthesis of derivatives / 有糸分裂阻害 / ホスファチジルコリン / レチノイン酸(retinoic acid) / 固相合成 / 天然物 / アシルCoA:コレスチロールアシル転移酵素 / 外傷性脳障害 / ペプチド / カルピナクタム / コレステロール輸送 / 天然物化学 / 細胞内輸送 / カビ代謝産物 / 金合成 / 休眠細胞活性化因子 / Acyl-CoA : cholesterol acyltransferase / トランスポート / cholesterol / 受容体拮抗薬 / foam cell / 蛋白質 / 酵素阻害剤 / 全合成 / アシルCoA合成酵素 / Total synthesis / ステロイド系阻害剤 / 抗エイズ薬 / Acly-Coa synthetase / 活性物質の構造決定 / Farnesyltransferase / Superoxide / アシルCoAコレステロールアシル転移酵素 / Superoxide dismutase / 殺がん細胞活性 / スーパーオキシドジスムターゼ / Pyripyropene / プロスタグランジン / 抗結核剤 / SRB1 / 活性酸素 / トリアクシン / SRBI / 抗生物質(antibiotics) / steroid / 脂質修飾蛋白質 / Andrastin / 抗真菌剤 / コレステロール代謝 / 海洋糸状菌 / 生合成 / 海洋生物素材 / 抗結核薬 / purification of active compounds / コレステリルエステル転送蛋白質 / Fungal metabolite / Micobial resources / リポ蛋白質 / Myristoylation / 新興感染症 / Inducers of microbial growth / Triacsin / アシルCoA:コレステロールアシル転移酵素 / HIV Gag蛋白質 / アシル化 / チロシンキナーゼ / スフィンゴミエリン / シクロデプシペプチド / 血管新生阻害 / ホヤ / パ-パクチン / 酵素 / Ras蛋白質 / アゾール系抗真菌剤 / 宿主 / elucidation of structure / Structure-activity relationship / 動脈硬化 / microbial resource / 泡沫化 / 抗マラリア剤 / cholesterol transport / 抗エイズ剤 / 微生物資源 / 脳・神経 / Unknown microorganisms / adhesion(接着) / グラム陽性高G+Cバクテリア / 微小管重合阻害 / marine products / カタラーゼ / Choresterol / 抗癌剤 / apoptosis(アポトーシス) / マクロファ-ジ / 未利用微生物 / HIV Gag protein / plant resource / コレステロ-ル / プロスタグランジンD2 / ACAT inhibitor / グリソプレニン / ミリストイル化 / 活性物質の精製 / SOD / 微生物生育増強因子 / アンドラスチン / 微生物素材 / アポE / ACAT阻害剤 / Ras protein / スカベンジャー受容体 / azole / 植物素材 / Leukemia(白血病) / ファルネシル化 / macrophage / 病原体 / New bioactive compounds / ライソソーム / 両生類 / 筋ジストロフィー / 炎症 / antimalarial drugs / 生物活性物質 / 新規有用物質 / Macropage Less

Collection and utilization of bioresources and natural products from IndonesiaPrincipal InvestigatorOngoing
- Principal Investigator
  
  供田洋
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kitasato University
Interaction between brain function and inflammation mediated by prostaglandin D2Ongoing
- Principal Investigator
  
  裏出良博
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  The University of Tokyo
  University of Tsukuba
Why do not die Japanese frogs with chytrid fungus.
- Principal Investigator
  
  UNE Yumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservation of biological resources
- Research Institution
  Azabu University
Study on the regioselective coupling reaction to produce atropisomers by enzymePrincipal Investigator
- Principal Investigator
  
  Tomoda Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Natural medicines
- Research Institution
  Kitasato University
微生物由来脂質代謝制御剤からの創薬を目指した基盤研究Principal InvestigatorOngoing
- Principal Investigator
  
  供田洋
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Natural medicines
- Research Institution
  Kitasato University
Development of anti-tuberculosis drugs based on calpinactam
- Principal Investigator
  
  NAGAI Kenichiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
THE CHEMICAL BIOLOGY OF NEW MICROBIAL ANTI-INFECTIVE AGENTSPrincipal Investigator
- Principal Investigator
  
  TOMODA Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kitasato University
Discovery and development of selectivity-defined inhibitors toward two acyl-CoA : cholesterol acyltransferase isozymesPrincipal Investigator
- Principal Investigator
  
  TOMODA Hiroshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
脂質代謝を制御する機能分子プローブの創製Principal Investigator
- Principal Investigator
  
  供田洋
- Project Period (FY)
  2004 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kitasato University
Isolation and application of new microorganisms from soil Samples
- Principal Investigator
  
  TAKAHASHI Yoko
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用微生物学
- Research Institution
  Kitasato University
Research of the antimalarial drugs from the natural products
- Principal Investigator
  
  OMURA Satoshi
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
  Kitasato Institute
Screening for inhibitors of Cholesteryl Ester Transfer ProteinPrincipal Investigator
- Principal Investigator
  
  TOMODA Hiroshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  The Kitasato Institute
海洋糸状菌、海綿、ホヤを対象としたがん化学療法剤の探索
- Principal Investigator
  
  浪越通夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  東京水産大学
白血病細胞のアポトーシス誘導ならびに浸潤阻止のための制御技術と天然薬物の開発
- Principal Investigator
  
  片桐拓也
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato Institute
Studies on fungal pyripyropenes, potent inhibitors of cholesterol metabolism
- Principal Investigator
  
  OMURA Satoshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The Kitasato Institute
Studies on the cellular functions of lipid-modified proteins
- Principal Investigator
  
  OHMURA Satoshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Kitasato Institute
Basic study for analysis and application of bio-factor which regulate transfer of cholresterol in vivo.
- Principal Investigator
  
  INOUE Keizo
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Tokyo
Inhibition of foam cell formation : Application to the discovery of novel antiatherosclerotic agents
- Principal Investigator
  
  OMURA Satoshi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Kitasato Institute

All 2018 2017 2016 2015 2014 2012 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book

[Book] 動脈硬化Update20082009
- Author(s)
  供田洋 (分担執筆)
- Publisher
  ライフサイエンス出版
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Discovery of a Fungal Multicopper Oxidase That Catalyzes the Regioselective Coupling of a Tricyclic Naphthopyranone To Produce Atropisomers.2018
- Author(s)
  Mio Kawaguchi, Taichi Ohshiro, Masayuki Toyoda, Satoshi Ohte, Junji Inokoshi, Isao Fujii, Hiroshi Tomoda
- Journal Title
  
  Angew Chem Int Ed.
  
  Volume: 57 Pages: 5115-5119
- DOI
  10.1002/anie.201800415
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05449, KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-17H03995, KAKENHI-PROJECT-16K18900
[Journal Article] Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp.2018
- Author(s)
  Kapojos MM, Abdjul DB, Yamazaki H, Ohshiro T, Rotinsulu H, Wewengkang DS, Sumilat DA, Tomoda H, Namikoshi M, Uchida R.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 28 Pages: 1911-1914
- DOI
  10.1016/j.bmcl.2018.03.077
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-16K18900
[Journal Article] Saturated fatty acids undergo intracellular crystallization and activate the NLRP3 inflammasome in macrophages.2018
- Author(s)
  Karasawa Tadayoshi、Kawashima Akira、Usui-Kawanishi Fumitake、Watanabe Sachiko、Kimura Hiroaki、Kamata Ryo、Shirasuna Koumei、Koyama Yutaro、Sato-Tomita Ayana、Matsuzaka Takashi、Tomoda Hiroshi、Park Sam-Yong、Shibayama Naoya、Shimano Hitoshi、Kasahara Tadashi、Takahashi Masafumi
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 38 Pages: 744-756
- DOI
  10.1161/atvbaha.117.310581
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09521, KAKENHI-PROJECT-17K09889, KAKENHI-INTERNATIONAL-15K21719, KAKENHI-PUBLICLY-16H01395, KAKENHI-PLANNED-17H06395, KAKENHI-ORGANIZER-26105001, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-15K09146, KAKENHI-PROJECT-16K19544
[Journal Article] Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors.2018
- Author(s)
  Ohtawa Masaki、Arima Shiho、Ichida Naoki、Terayama Tomiaki、Ohno Hironao、Yamazaki Takaya、Ohshiro Taichi、Sato Noriko、Omura Satoshi、Tomoda Hiroshi、Nagamitsu Tohru
- Journal Title
  
  ChemMedChem.
  
  Volume: 13 Pages: 411-421
- DOI
  10.1002/cmdc.201700645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08370, KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-16K18900
[Journal Article] Variation in the activity of distinct cytochalasins as autophagy inhibitiors in human lung A549 cells2017
- Author(s)
  Takanezawa Y, Nakamura R, Sone Y, Uraguchi S, Kobayashi K, Tomoda H, Kiyono M.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 494 Pages: 641-647
- DOI
  10.1016/j.bbrc.2017.10.135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-16K15381
[Journal Article] Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-12017
- Author(s)
  Suzuki A, Fukuda T, Kobayashi K, Ohshiro T, Tomoda H.
- Journal Title
  
  Journal of Antibiotics
  
  Volume: 70 Pages: 798-805
- DOI
  10.1038/ja.2016.46
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-15J12265, KAKENHI-PROJECT-16K18900, KAKENHI-PROJECT-15K07417
[Journal Article] Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium2017
- Author(s)
  Iwasaki A, Tadenuma T, Sumimoto S, Ohshiro T, Ozaki K, Kobayashi K, Teruya T, Tomoda H, Suenaga K.
- Journal Title
  
  Journal of Natural Products
  
  Volume: 80 Pages: 116101166-116101166
- DOI
  10.1021/acs.jnatprod.7b00137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-16K18900, KAKENHI-PROJECT-16H03285, KAKENHI-PROJECT-15K01803
[Journal Article] Scopranones with Two Atypical Scooplike Moieties Produced by Streptomyces sp. BYK-11038.2017
- Author(s)
  Uchida Ryuji、Lee Daiki、Suwa Ibuki、Ohtawa Masaki、Watanabe Nozomu、Demachi Ayumu、Ohte Satoshi、Katagiri Takenobu、Nagamitsu Tohru、Tomoda Hiroshi
- Journal Title
  
  Org Lett.
  
  Volume: 19 Pages: 5980-5983
- DOI
  10.1021/acs.orglett.7b03003
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15134, KAKENHI-PROJECT-26253009
[Journal Article] Selective inhibition of sterol O-acyltransferase 1 isozyme by beauveriolide III in intact cells.2017
- Author(s)
  T. Ohshiro, K. Kobayashi, M. Ohba, D. Matsuda, L. L. Rudel, T. Takahashi, T. Doi, H. Tomoda
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Pages: 4163-4163
- DOI
  10.1038/s41598-017-04177-8
- Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05837, KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-16K18900
[Journal Article] Design, Synthesis, and Biological Evaluation of Beauveriolide Analogues Bearing Photoreactive Amino Acids2016
- Author(s)
  Masuda Y, Aoyama K, Yoshida M, Kobayashi K, Ohshiro T, Tomoda H, Doi T.
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 64 Issue: 7 Pages: 754-765
- DOI
  10.1248/cpb.c16-00095
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-26282208, KAKENHI-PROJECT-26850068, KAKENHI-PROJECT-16K07707, KAKENHI-PROJECT-16K18900
[Journal Article] 7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007.2016
- Author(s)
  Uchida R, Nakajyo K, Kobayashi K, Ohshiro T, Terahara T, Imada C, Tomoda H.
- Journal Title
  
  J Antibiot.
  
  Volume: 69 Pages: 647-651
- DOI
  10.1038/ja.2016.27
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-16K18900
[Journal Article] Discovery of SOAT2 inhibitors from synthetic small molecules.2016
- Author(s)
  Kobayashi, K.; Ohshiro, T.; Tomoda, H.; Yin, F.; Cui, H.-L.; Chouthaiwale, P. V.; Tanaka, F.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 26 Pages: 5899-5901
- DOI
  10.1016/j.bmcl.2016.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26105757, KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-15J12265, KAKENHI-PROJECT-16K18900
[Journal Article] PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient mice.2015
- Author(s)
  Lopez AM, Chuang JC, Posey KS, Ohshiro T, Tomoda H, Rudel LL, Turley SD.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 355 Pages: 159-67
- DOI
  10.1124/jpet.115.227207
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253009
[Journal Article] Acyltransferase inhibitors: a patent review (2010-present).2015
- Author(s)
  Ohshiro T, Tomoda H.
- Journal Title
  
  Expert Opin Ther Pat
  
  Volume: 25 Pages: 145-158
- DOI
  10.1517/13543776.2014.989833
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253009
[Journal Article] Clonoamide, a new inhibitor of sterol O-acyltransferase, produced by Clonostachys sp. BF-0131.2015
- Author(s)
  Kobayashi K, Tsukasaki N, Uchida R, Yamaguchi Y, Tomoda H.
- Journal Title
  
  J Antibiot
  
  Volume: 68 Pages: 615-619
- DOI
  10.1038/ja.2015.37
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253009
[Journal Article] New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.2015
- Author(s)
  Ohshiro, T.; Ohtawa, M.; Nagamitsu, T.; Matsuda, D.; Yagyu, H.; Davis, M. A.; Rudel, L. L.; Ishibashi, S.; Tomoda, H.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 355 Pages: 299-307
- DOI
  10.1124/jpet.115.227348
- Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26253009
[Journal Article] Diketopiperazines, inhibitors of sterol O-acyltransferase, produced by a marine-derived Nocardiopsis sp. KM2-16.2015
- Author(s)
  Kobayashi K., Tsukasaki N., Uchida R., Yamaguchi Y., Tomoda H.
- Journal Title
  
  J Antibiot
  
  Volume: 68 Pages: 615-619
- DOI
  10.1038/ja.2015.38
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15J12265, KAKENHI-PROJECT-26253009
[Journal Article] Bafilomycin L, a new inhibitor of cholesteryl ester synthesis in mammalian cells, produced by marine-derived Streptomyces sp. OPMA00072.2015
- Author(s)
  Kobayashi K., Fukuda T., Usui T., Kurihara Y., Kanamoto A., Tomoda H.
- Journal Title
  
  J Antibiot
  
  Volume: 68 Pages: 126-132
- DOI
  10.1038/ja.2014.100
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15J12265, KAKENHI-PROJECT-26253009
[Journal Article] In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites.2015
- Author(s)
  Ohshiro, T.; Matsuda, D.; Ohtawa, M.; Yamazaki, H.; Nagamitsu. T.; Tomoda, H.
- Journal Title
  
  J Antibiot
  
  Volume: 68 Pages: 27-34
- DOI
  10.1038/ja.2014.91
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-26460013, KAKENHI-PROJECT-26253009
[Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014
- Author(s)
  Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Pages: 2082-2092
- DOI
  10.1194/jlr.m050864
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533, KAKENHI-PROJECT-26253009
[Journal Article] Molecular cloning of the gene cluster for lariatin biosynthesis of Rhodococcus jostii K01-B01712012
- Author(s)
  Inokoshi J, Matsuhama M, Miyake M, Ikeda H, Tomoda H.
- Journal Title
  
  Applied Microbiology and Biotechnology
  
  Volume: (In press) Pages: 451-460
- DOI
  10.1007/s00253-012-3973-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310146, KAKENHI-PLANNED-22108006
[Journal Article] Synthesis and antimycobacterial activity of calpinactam derivatives2012
- Author(s)
  Kenichiro Nagai, Nobuhiro Koyama, Noriko Sato, Chisato Yanagisawa, Hiroshi Tomoda
- Journal Title
  
  Bioorg.Med.Chem.Lett
  
  Volume: 22 Pages: 7739-7741
- URL
  http://dx.doi.org/10.1016/j.bmcl.2012.09.069
- Data Source
  KAKENHI-PROJECT-23790019
[Journal Article] Mode of Action of Microbial Anti-MRSA Agents2012
- Author(s)
  Tomoda H.
- Journal Title
  
  薬学雑誌
  
  Volume: 132 Issue: 1 Pages: 37-44
- DOI
  10.1248/yakushi.132.37
- ISSN
  0031-6903, 1347-5231
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-21310146
[Journal Article] 新しい抗感染症剤研究の最前線—発見，ケミカルバイオロジーそして創薬へ—2012
- Author(s)
  Tomoda H, et al
- Journal Title
  
  薬学雑誌
  
  Volume: 132 Issue: 1 Pages: 35-36
- DOI
  10.1248/yakushi.132.35
- ISSN
  0031-6903, 1347-5231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310146
[Journal Article] Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-12009
- Author(s)
  Yamazaki H, Omura S, Tomoda H
- Journal Title
  
  II. Structure elucidation. J. Antibiot 62
  
  Pages: 207-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Pentacecilides new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1 : I. Taxonomy, fermentation, isolation and biological properties2009
- Author(s)
  Yamazaki H, Kobayashi K, Matsuda D, Nonaka K, Masuma R, Omura S, Tomoda H.
- Journal Title
  
  J. Antibiot 62
  
  Pages: 195-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Total synthesis of amidepsine B and revision of its absolute configuration2009
- Author(s)
  Nagamitsu T, Marumoto K, Nagayasu A, Fukuda T, Arima S, Uchida R, Ohshiro T, Harigaya Y, Tomoda H, Omura S.
- Journal Title
  
  J. Antibiot 62
  
  Pages: 69-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] The selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA2009
- Author(s)
  Ohshiro T, Matsuda D, Nagai K, Doi T, Sunazuka T, Takahashi T, Rudel LL, Omura S, Tomoda H.
- Journal Title
  
  cholesterol acyltransferase . Chem. Pharm. Bull 57
  
  Pages: 377-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Expression of two human acyl-CoA : diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes2009
- Author(s)
  Inokoshi J, Kawamoto K, Takagi Y, Matsuhama M, Omura S, Tomoda H.
- Journal Title
  
  J. Antibiot 62
  
  Pages: 51-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Discovery and combinatorial synthesis of fungal metabolites beauveriolides, novel antiatherosclerotic agents.2008
- Author(s)
  Tomoda H, Doi T.
- Journal Title
  
  Acc. Chem. Res. 41
  
  Pages: 32-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Synthesis and biological evaluation of a focused library of beauveriolides2008
- Author(s)
  Nagai K, Doi T, Ohshiro T, Sunazuka T, Tomoda H, Takahashi T, Omura S.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 4397-4400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages2008
- Author(s)
  Matsuda D, Ohte S, Ohshiro T, Jiang W,Rudel L, Hong B, Si S, Tomoda H.
- Journal Title
  
  Biol. Pharm. Bull. 31
  
  Pages: 1063-1066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA : cholesterol acyltransferase 2 isozyme2008
- Author(s)
  Ohshiro T, Ohte S, Matsuda D, Ohtawa M, Nagamitsu T, Sunazuka T, Harigaya Y, Rudel LL, Omura S, Tomoda H.
- Journal Title
  
  J. Antibiot 61
  
  Pages: 503-508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Inhibition of lipid droplet accumulation in mouse macrophages by stemphone derivatives.2008
- Author(s)
  Koyama N, Kobayashi K, Yamazaki H, Tomoda H.
- Journal Title
  
  J. Antibiot 61
  
  Pages: 509-514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Selective inhibition of acyl-CoA : cholesterol acyltransferase 2 isozyme by flavasperone and sterigmatocystin from Aspergillus species2008
- Author(s)
  Sakai K, Ohte S, Ohshiro T, Matsuda D, Masuma R, Rudel LL, Tomoda H.
- Journal Title
  
  J. Antibiot 61
  
  Pages: 568-572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT22008
- Author(s)
  Parini P, Gustafsson U, Davis MA, Larsson L, Einarsson C, Wilson M, Rudling M, Tomoda H, Omura S, Sahlin S, Angelin B, Rudel LL, Eriksson M.
- Journal Title
  
  Arterioscler. Thromb. Vasc. Biol. 28
  
  Pages: 1200-1206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Identification of the interaction site within acyl-CoA : cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A.2008
- Author(s)
  Das A, Davis MA, Tomoda H, Omura S, Rudel LL.
- Journal Title
  
  J. Biol. Chem. 18
  
  Pages: 10453-10460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Potential therapeutics for obesity and atherosclerosis : inhibitors of neutral lipid metabolism from microorganisms2007
- Author(s)
  Tomoda H, Omura S.
- Journal Title
  
  Pharmacol. Ther 115
  
  Pages: 375-389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Discovery and combinatorial synthesis of fungal metabolitebeauveriolides, novel antiatherosclerotic agents2007
- Author(s)
  Tomoda, H., et. al.
- Journal Title
  
  Ace. Chem. Res. 41
  
  Pages: 32-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073215
[Journal Article] DGAT inhibitors for obesity2007
- Author(s)
  Matsuda D, Tomoda H.
- Journal Title
  
  Curr. Opin. Investig. Drugs. 8
  
  Pages: 836-841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Potential therapeutics for obesity and atherosclerosis:inhibitors of neutral lipid metabolism from microorganisnis2007
- Author(s)
  Tomoda, H., et. al.
- Journal Title
  
  Pharmacol. Ther. 115
  
  Pages: 375-389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073215
[Journal Article] Fungal isobisvertional, a new inhibitor of lipid droplet accumulation in mouse macrophages2007
- Author(s)
  Koyama N, Ohshiro T, Tomoda H, Omura S.
- Journal Title
  
  Org. Lett. 9
  
  Pages: 425-428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] DGAT inhibitors of obesity2007
- Author(s)
  Matsuda, D.&Tomoda, H.
- Journal Title
  
  Curr. Opin Investig. Drugs 8
  
  Pages: 836-841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Potential therapeutics for obesity and atherosclerosis:inhibitors of neutral lipid metabolism from microorganisms2007
- Author(s)
  Tomoda, H.&Omura, S.
- Journal Title
  
  Pharmacol.Ther. 115
  
  Pages: 375-389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Selectivity of microbial acyl-CoA : cholesterol acyltransferase inhibitors toward isozymes.2007
- Author(s)
  Ohshiro T, Rudel LL, Omura S, Tomoda H.
- Journal Title
  
  J. Antibiot 60
  
  Pages: 43-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Discovery and combinatorial synthesis of fungal metabolite beauveriolides, novel antiatherosclerotic agents2007
- Author(s)
  Tomoda, H.&Doi, T.
- Journal Title
  
  Acc.Chem.Res. 41
  
  Pages: 32-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] 脂質代謝を制御する機能分子の開拓2006
- Author(s)
  供田洋
- Journal Title
  
  化学工業 57 (10)
  
  Pages: 734-739
- Data Source
  KAKENHI-PROJECT-16073215
[Journal Article] 脂質代謝を制御する機能分子の開拓2006
- Author(s)
  供田洋
- Journal Title
  
  化学工業 57(10)
  
  Pages: 734-739
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] 創薬を目指した微生物由来脂質代謝阻害剤2005
- Author(s)
  供田洋
- Journal Title
  
  バイオサイエンスとインダストリー 63(4)
  
  Pages: 16-22
- Data Source
  KAKENHI-PROJECT-16073215
[Journal Article] Binding site for fungal β-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase.2004
- Author(s)
  Tomoda, H. et al.
- Journal Title
  
  Biochim.Biophys.Acta 1636
  
  Pages: 22-28
- Data Source
  KAKENHI-PROJECT-16073215
[Journal Article] 中性脂質合成酵素とそれを制御する微生物由来低分子化合物2004
- Author(s)
  供田洋
- Journal Title
  
  ファルマシア 40
  
  Pages: 714-718
- Data Source
  KAKENHI-PROJECT-16073215
[Presentation] 真菌由来の新規 SOAT 阻害剤 celludinone A の立体化学に関する研究2018
- Author(s)
  関怜子、大城太一、供田洋
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] ピリピロペン誘導体の抗動脈硬化作用 (II)2018
- Author(s)
  大城太一、大多和正樹、長光亨、Lawrence RUDEL、供田洋
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 中性脂質蓄積阻害剤 dinapinone A の結合タンパク質の解析2018
- Author(s)
  奥畑颯眞、小林啓介、供田洋
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 軸異性を有する真菌由来化合物ダイナピノンが示す脂肪滴分解促進活性の作用機序解析2017
- Author(s)
  小林啓介、大城太一、大手聡、供田洋
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] Drug discovery of inhibitors of sterol O-acyltransferase from microorganisms.2017
- Author(s)
  Tomoda H
- Organizer
  2nd World Congress & Expo on Pharmaceutics & Drug Delivery Systems
- Place of Presentation
  Kuala Lumpur, Malaysia
- Year and Date
  2017-03-27
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 真菌由来化合物 dinapinone 類が示す中性脂質蓄積阻害活性の作用機序解析2017
- Author(s)
  小林啓介、大城太一、小山信裕、大手聡、供田洋
- Organizer
  平成29年度生命科学系合同年次大会
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] Dinapinone A による脂質分解促進活性に関する研究2017
- Author(s)
  小林啓介、大城太一、供田洋
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] SOAT2 選択的阻害剤は脂肪性肝疾患に有効か?2017
- Author(s)
  大城太一、大多和正樹、長光亨、Rudel Lawrence L.、石橋俊、供田洋
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 位置選択的モナピノン二量体化酵素 MCE の基質特異性に関する研究2017
- Author(s)
  大城太一、豊田雅幸、川口未央、供田洋
- Organizer
  平成29年度生命科学系合同年次大会
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] ボーベリオライド誘導体の抗動脈硬化作用2017
- Author(s)
  大城太一、伊牟田聡、土黒一郎、高橋孝志、土井隆行、石橋俊、供田洋
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 土壌由来真菌が生産する新規 SOAT2 選択的阻害剤に関する研究2017
- Author(s)
  関怜子、大城太一、福田隆志、内田龍児、供田洋
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] Monapinone 二量体化酵素による新規 dinapinone 類の酵素学的解析2017
- Author(s)
  豊田雅幸、大城太一、出町歩、小林啓介、川口未央、供田洋
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26670050
[Presentation] なぜ beauveriolide III はインタクト細胞で sterol O-acyltransferase 1選択的阻害活性を示すのか？2016
- Author(s)
  小林啓介、大城太一、高橋孝志、土井隆行、供田洋
- Organizer
  第21回天然薬物の開発と応用シンポジウム
- Place of Presentation
  千葉市
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 真菌由来 beauveriolide Ⅲ の SOAT アイソザイム阻害活性機構に関する研究2016
- Author(s)
  小林啓介、大城太一、供田洋
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] ピリピロペン誘導体の抗動脈硬化作用2016
- Author(s)
  大城太一、大多和正樹、長光亨、松田大介、野牛宏晃、Matthew DAVIS、Lawrence RUDEL、石橋俊、供田洋
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 真菌 Talaromyces pinophilus FKI-3864 由来の monapinone カップリング酵素の異種発現系の構築2016
- Author(s)
  出町歩、石掛太樹、猪腰淳嗣、藤井勲、供田洋
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-26670050
[Presentation] 海洋放線菌 Streptomyces sp. KM10-4 株が生産するトリグリセリド蓄積阻害活性物質に関する研究2016
- Author(s)
  鈴木あいか、福田隆志、小林啓介、大城太一、瀧誠二、山田勝久、寺原猛、今田千秋、供田洋
- Organizer
  第18回マリンバイオテクノロジー学会大会
- Place of Presentation
  函館市
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 細胞内の脂肪滴分解を促進する真菌由来化合物 dinapinone A の作用機序解析2016
- Author(s)
  小林啓介、大城太一、供田洋
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] A novel inhibitor of neutral lipid synthesis produced by hot spring-derived fungus Aspergillus sp. BF142.2016
- Author(s)
  Furukawa T, Fukuda T, Uchida R, Kobayashi K, Tomoda H.
- Organizer
  The 8th Japan-Korea Chemical Biology Symposium
- Place of Presentation
  Okinawa (Pacific hotel Okinawa)
- Year and Date
  2016-01-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] SOAT2選択的阻害剤ピリピロペン誘導体の抗動脈硬化作用2016
- Author(s)
  大城太一、大多和正樹、長光亨、Lawrence L. Rudel、供田洋
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  秋田市
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 土壌由来真菌BF-0307株が産生する中性脂質蓄積阻害物質に関する研究2016
- Author(s)
  関怜子、小林啓介、大城太一、福田隆志、内田龍児、供田洋
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 微生物由来脂質代謝阻害剤からの創薬への挑戦2016
- Author(s)
  供田洋
- Organizer
  第54回ヒューマンサイエンス・バイオインターフェース講演会
- Place of Presentation
  東京
- Year and Date
  2016-05-31
- Invited
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] Monapinone 二量体化酵素の精製方法の改良2016
- Author(s)
  豊田雅幸、石掛太樹、猪腰淳嗣、供田洋
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-26670050
[Presentation] Sterol O-acyltransferase アイソザイムに対する beauveriolide IIIの阻害機構の解明2016
- Author(s)
  小林啓介、大城太一、供田洋
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  秋田市
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] Selective inhibition of beauveriolide III against SOAT isozymes.2016
- Author(s)
  Kobayashi K, Ohshiro T, Rudel LL, Tomoda H.
- Organizer
  The 8th Japan-Korea Chemical Biology Symposium
- Place of Presentation
  Okinawa (Pacific hotel Okinawa)
- Year and Date
  2016-01-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 微生物由来機能分子のケミカルバイオロジー2015
- Author(s)
  供田洋
- Organizer
  高磁場・高感度NMR利活用促進のための天然物関連シンポジウム2015
- Place of Presentation
  横浜（理化学研究所横浜キャンパス）
- Year and Date
  2015-08-21
- Invited
- Data Source
  KAKENHI-PROJECT-26670050
[Presentation] 海洋由来真菌 Aspergillus unguis NKM - 007株が生産する新規 depsidoneに関する研究2015
- Author(s)
  内田龍児、中條賢人、小林啓介、寺原猛、今田千秋、供田洋
- Organizer
  第17回マリンバイオテクノロジー学会大会
- Place of Presentation
  東京（東京海洋大学）
- Year and Date
  2015-05-31
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 海洋由来放線菌が生産する sterol-O-acyltransferase 阻害活性を示す diketopiperazine 化合物に関する研究2015
- Author(s)
  小林啓介、福田隆志、寺原猛、春成円十朗、今田千秋、供田洋
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸（神戸学院大学)
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] セルレニン生産菌の脂肪酸合成酵素遺伝子の解析2015
- Author(s)
  出町歩、猪腰淳嗣、藤井勲、供田洋
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸（神戸学院大学)
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 微生物資源からの創薬研究2015
- Author(s)
  供田洋
- Organizer
  第23回クリニカルファーマシーシンポジウム／医療薬学フォーラム
- Place of Presentation
  名古屋(名古屋国際会議場）
- Year and Date
  2015-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 土壌細菌 BYK11209 株が生産する新規中性脂質生成阻害物質に関する研究2015
- Author(s)
  鈴木あいか、小林啓介、福田隆志、内田龍児、供田洋
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸（神戸学院大学)
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 海洋由来真菌 Aspergillus sp. NKM-007 株が生産する新規 depsidone に関する研究2015
- Author(s)
  中條賢人、内田龍児、小林啓介、寺原猛、今田千秋、供田洋
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸（神戸学院大学)
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 温泉由来真菌 BF142 株が産生する新規中性脂質生成阻害物質に関する研究2015
- Author(s)
  古川茶勲、福田隆志、小林啓介、内田龍児、供田洋
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸（神戸学院大学)
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] Microbial inhibitors of lipid metabolism---from discovery to challenge for development---2015
- Author(s)
  Tomoda H.
- Organizer
  Liver Academy at Karolinska
- Place of Presentation
  Stockholm, Sweden (Karolinska Institute)
- Year and Date
  2015-12-08
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 脂質代謝を制御する微生物由来化合物2015
- Author(s)
  供田　洋
- Organizer
  北里大学薬学部創設50周年記念第34回白金シンポジウム
- Place of Presentation
  北里大学薬学部コンベンションホール（東京都港区）
- Year and Date
  2015-02-28
- Invited
- Data Source
  KAKENHI-PROJECT-26670050
[Presentation] 海洋由来放線菌が生産する細胞内中性脂質制御物質に関する研究2015
- Author(s)
  小林啓介、福田隆志、寺原猛、春成円十朗、今田千秋、供田洋
- Organizer
  第17回マリンバイオテクノロジー学会大会
- Place of Presentation
  東京（東京海洋大学）
- Year and Date
  2015-05-31
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 脂質代謝を制御する微生物由来化合物2015
- Author(s)
  供田　洋
- Organizer
  北里大学薬学部創設50周年記念第34回白金シンポジウム
- Place of Presentation
  東京（北里大学白金キャンパス）
- Year and Date
  2015-02-28
- Invited
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 温泉由来真菌 BF142 株の産生する新規中性脂質生成阻害物質に関する研究2015
- Author(s)
  古川茶勲、福田隆志、小林啓介、内田龍児、供田洋
- Organizer
  新規素材探索研究会第14回セミナー
- Place of Presentation
  神奈川（新横浜フジビューホテル）
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 微生物由来脂質代謝阻害剤を求めて---発見、ケミカルバイオロジー、創薬へ --2014
- Author(s)
  供田　洋
- Organizer
  第6回ケミカルバイオロジー勉強会
- Place of Presentation
  鈴木梅太郎ホール（埼玉県・和光市）
- Year and Date
  2014-04-30
- Invited
- Data Source
  KAKENHI-PROJECT-26670050
[Presentation] Discovery of useful bioactive compounds from microorganisms.2014
- Author(s)
  Tomoda H
- Organizer
  Okinawa Institute of Science and Technology Graduate University (OIST)
- Place of Presentation
  沖縄（OIST)
- Year and Date
  2014-12-19
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] 微生物由来脂質代謝阻害剤を求めて---発見、ケミカルバイオロジー、創薬へ ---2014
- Author(s)
  供田　洋
- Organizer
  第６回ケミカルバイオロジー研究会
- Place of Presentation
  埼玉（和光）
- Year and Date
  2014-04-30
- Invited
- Data Source
  KAKENHI-PROJECT-26253009
[Presentation] Mechanism of action of new anti-infectious agents from microorganisms2011
- Author(s)
  Tomoda H.
- Organizer
  The Uehara Memorial Foundation Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] Mechanism of action of new anti-infectious agents from microorganisms2011
- Author(s)
  Tomoda H
- Organizer
  The uehara memorial foundation symposium 2011
- Place of Presentation
  Tokyo
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] 微生物由来の抗MRSA剤の作用機構の解析2011
- Author(s)
  供田洋
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡(一般シンポジウム)
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] 微生物由来の抗MRSA剤の作用機構の解析2011
- Author(s)
  供田洋
- Organizer
  日本薬学会第131年会一般シンポジウム
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] Mechanism of action of cyslabdan, a potentiator of imipenem activity against MRSA2011
- Author(s)
  Tomoda H
- Organizer
  Inaugural Metting of Bergey's International Society for Microbial Systematics
- Place of Presentation
  Beijing, China
- Year and Date
  2011-05-22
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] New anti-mycobacterial peptide antibiotics, lariatin and calpinactam2010
- Author(s)
  Tomoda H
- Organizer
  FIP2010
- Place of Presentation
  Lisbon, Portugal
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] 真菌由来beauveroilide III のACAT1 選択的阻害活性に関する研究2009
- Author(s)
  大場未央、松田大介、大城太一、土井隆行、高橋孝志、大村智、供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] Discovery for New Anti-Mycobacterial Agents from Microorganisms.2009
- Author(s)
  Tomoda H
- Organizer
  Australia-Japan Workshop on Biodiversity
- Place of Presentation
  Canberra, Australia
- Year and Date
  2009-10-28
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] カイコ感染症モデルを利用した治療効果を示す抗生物質の探索2009
- Author(s)
  供田洋
- Organizer
  医学・創薬研究を支えるヒトと昆虫の生物資源-病理と病態モデル-
- Place of Presentation
  東京
- Year and Date
  2009-11-21
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] ACAT2 選択的阻害剤ピリピロペンA の抗動脈硬化作用2009
- Author(s)
  坂井謙斗、大城太一、松田大介、野牛宏晃、Lawrence Rudel、大村智、石橋俊、供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] ACAT2 選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関2009
- Author(s)
  大多和正樹、山崎寛之、松田大介、大城太一、針谷義弘、長光亨、大村智、供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] アイソザイム選択的阻害剤の開拓2009
- Author(s)
  供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] ACAT 阻害剤の復活をめざして2008
- Author(s)
  供田洋
- Organizer
  北里大学薬学部特別公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-10-08
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] 天然資源からの新しい抗動脈硬化薬の開拓研究2008
- Author(s)
  供田洋
- Organizer
  動脈硬化Update2008
- Place of Presentation
  東京
- Year and Date
  2008-09-06
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] 真菌FO-2942 株の生産する新しいamidepsine 成分に関する研究2008
- Author(s)
  高木陽一, 猪腰淳嗣, 内田龍児, 増間碌郎, 大村智, 供田洋
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] Suppression of lipid droplet accumulation in mouse peritoneal macrophages by piperine2008
- Author(s)
  D. Matsuda, S. Ohte, T. Ohshiro, W. Jiang, L. L. Rudel, B. Hong, S. Si, H. Tomoda
- Organizer
  The 4^<th> Korea-Japan Joint Symposium Chemical Biology for Bioactive Molecules
- Place of Presentation
  Kinugawa, Tochigi, Japan
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] マクロファージ内脂肪滴蓄積阻害剤beauveriolide の標的分子の解析2008
- Author(s)
  松田大介、大城太一、土井隆行、大場未央、高橋孝志、大村智、供田洋
- Organizer
  第31回日本分子生物学会年会第81 回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] Microbial products inhibiting neutral lipid synthesis2008
- Author(s)
  Tomoda H.
- Organizer
  The 12th Japan-Korea Joint Symposium Drug Design and Development
- Place of Presentation
  Sendai, Japan
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] ACAT阻害剤beauveriolide III の誘導体合成と構造活性相関2008
- Author(s)
  伊牟田聡、広木康洋、土黒一郎、高橋孝志、土井隆行、大城太一、山崎寛之、松田大介、大村智、供田洋
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] ACAT2 選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関2008
- Author(s)
  大多和正樹、山崎寛之、松田大介、大城太一、針谷義宏、長光亨、大村智、供田洋
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] 海洋由来真菌 Aspergillus clavatonanicusFKI-1746 株の生産する新規マクロファーシ脂肪滴蓄積阻害物質2008
- Author(s)
  小山信裕、井上勇佑、野中健一、山口裕一、増間碌郎、大村智、供田洋
- Organizer
  第11 回マリンバイオテクノロジー学会大会
- Place of Presentation
  京都
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] 黒胡椒成分piperine によるマクロファージ内脂肪滴蓄積阻害作用2008
- Author(s)
  松田大介、大城太一、司書毅、供田洋
- Organizer
  第128 回日本薬学会年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] マクロファージ内脂肪滴蓄積阻害活性を示すツルリンドウ由来成分の作用機序の解析2008
- Author(s)
  松田大介、小林翔、深澤征義、西島正弘、花田賢太郎、司書毅、供田洋
- Organizer
  第21 回バイオサイエンスフォーラム
- Place of Presentation
  相模原
- Year and Date
  2008-08-01
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] Bioactive products from marine-derived microorganism as probes in chemical biology2007
- Author(s)
  H. Tomoda, D. Matsuda
- Organizer
  VI^<TM> US-Japan seminar : frontiers in marine natural productsresearch
- Place of Presentation
  Park city, Utah, USA
- Year and Date
  2007-06-06
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] Bioactive products from marine-derived microorganism as probes in chemical biology2007
- Author(s)
  Tomoda, H.&Matsuda, D.
- Organizer
  VI^<TM> US-Japan seminar:frontiers in marine natural products research
- Place of Presentation
  Park city,Utah,USA
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] 海洋由来脂質代謝阻害剤を用いたケミカルバイオロジー2007
- Author(s)
  松田大介、供田洋
- Organizer
  第10回マリンバイオテクノロジー学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-16073215
[Presentation] Bioactive products from marine-derived microorgamsm as probes in chemical biology2007
- Author(s)
  Tomoda, H. & Matsuda, D.
- Organizer
  VI^<TM> us-Japan seminar: frontiers in marine naturalproducts research
- Place of Presentation
  Park city, Utah
- Data Source
  KAKENHI-PROJECT-16073215
[Presentation] 海洋由来脂質代謝阻害剤を用いたケミカルバイオロジー2007
- Author(s)
  松田大介、供田洋
- Organizer
  第10回マリンバイオテクノロジー学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] 海洋由来脂質代謝阻害剤を用いたケミカルバイオロジー2007
- Author(s)
  松田大介、供田洋
- Organizer
  第10回マリンバイオテクノロジー学会
- Place of Presentation
  山形
- Year and Date
  2007-05-27
- Data Source
  KAKENHI-PROJECT-18390008

1. OMURA Satoshi (90050426)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. INOKOSHI Junji (30151640)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. KOYAMA Nobuhiro (60439156)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. ARAI Hiroyuki (40167987)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. NAGAMITSU Tohru (90300756)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. TABATA Noriko (60260080)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUNAZUKA Toshiaki (30226592)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. ISHIBASHI Shun (90212919)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. TAKAHASHI Yoko (80197186)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SHIOMI Kazuro (40235502)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 林正彦 (20164965)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. UCHIDA Ryuji (60280632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. UMEYAMA Hideaki (20050619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAGAI Kenichiro (30321649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. KUDO Ichiro (30134612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. INOUE Keizo (30072937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. AOKI Junken (20250219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OBATA Rika (20260078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MASUMA Rokuro (90219353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MORIKAWA Yuko (20191017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. OTOGURO Kazuhiko (80118794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YAMADA Haruki (60096691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. UI Hideaki (90290957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KIYOHARA Hiroaki (70161601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. ARAI Masahoshi (80311231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. UNE Yumi (40160303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 浪越通夫 (30189196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 片桐拓也 (70126100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 塚本俊彦 (10236862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 奥田重信 (30013296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 裏出良博 (10201360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 藤森功 (70425453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 相原一 (80222462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 島本茂 (00610487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 大城太一 (30458765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
36. 大手聡 (00547979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 小林啓介 (80794734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. SATO Noriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
39. SAEKI Takao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. OOSUGA Junniti

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. OHTAWA Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
42. TERUYA Toshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. USUI Fumitake

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 土井隆行

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
45. 増田裕一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 永島秀一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 高橋学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 山室大介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 清野正子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 福田隆志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 藤井勲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 末永聖武

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 高橋将文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 木村博昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. 唐澤直義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 渡邊幸子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 松坂賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 島野仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. 高橋敏男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
60. 有馬志保

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tomoda Hiroshi 供田 洋

TOMODA Hiroshi 共田 洋

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Collection and utilization of bioresources and natural products from IndonesiaPrincipal InvestigatorOngoing

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Interaction between brain function and inflammation mediated by prostaglandin D2Ongoing

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Study on the regioselective coupling reaction to produce atropisomers by enzymePrincipal Investigator

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微生物由来脂質代謝制御剤からの創薬を目指した基盤研究Principal InvestigatorOngoing

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THE CHEMICAL BIOLOGY OF NEW MICROBIAL ANTI-INFECTIVE AGENTSPrincipal Investigator

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Discovery and development of selectivity-defined inhibitors toward two acyl-CoA : cholesterol acyltransferase isozymesPrincipal Investigator

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脂質代謝を制御する機能分子プローブの創製Principal Investigator

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Screening for inhibitors of Cholesteryl Ester Transfer ProteinPrincipal Investigator

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Tomoda Hiroshi 供田洋

TOMODA Hiroshi 共田洋