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Kodo Kazuki  古道 一樹

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KODO Kazuki  古道 一樹

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Researcher Number 10338105
Other IDs
Affiliation (Current) 2025: 慶應義塾大学, 医学部(信濃町), 講師(非常勤)
Affiliation (based on the past Project Information) *help 2018 – 2024: 慶應義塾大学, 医学部(信濃町), 講師
2017: 慶應義塾大学, 医学部, 助教(有期)
2010 – 2012: 慶應義塾大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics
Except Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics
Keywords
Principal Investigator
心臓前駆細胞 / iPS細胞 / ゲノム編集 / 心臓流出路発生 / 遺伝子変異 / 先天性心疾患 / 心筋発生 / 心筋症 / サルコメア / 低酸素 … More / 左室心筋緻密化障害 / 胎児心筋細胞 / 心臓発生 / 発生・分化 / 再生医学 / 心臓領域 / 心筋前駆細胞 / モノクロタリン / エンドセリン / VEGF / 肺血管平滑筋 / 肺血管内皮 / IP3受容体 / 肺高血圧 / 小児循環器学 … More
Except Principal Investigator
Tbx20 / 循環器・高血圧 / シグナル伝達 / 発現制御 / 遺伝子 / 発生・分化 / Tbx1 / 総動脈幹症 / 多因子遺伝 / 先天性心疾患 / 葉酸 / 二次心臓領域 / 心臓神経堤細胞 / TBX1 / 形熊形成 / モデル動物 / 分子生物学 / 発生医学 / 細胞分化 / 形態形成 / 小児循環器学 Less
  • Research Projects

    (7 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (10 People)
  •  先天性心疾患治療開発へ向けた心臓流出路発生異常の主要原因遺伝子TMEM260の機能解明Principal Investigator

    • Principal Investigator
      古道 一樹
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Keio University
  •  モデル動物とiPS細胞を用いた心臓前駆細胞発生制御による予防医学的基礎研究

    • Principal Investigator
      山岸 敬幸
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Keio University
  •  Elucidation of the mechanism of genotype-phenotype correlation in cardiomyopathy using disease-specific isogenic iPS cellsPrincipal Investigator

    • Principal Investigator
      Kodo Kazuki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Keio University
  •  Genetic-environmental interaction for congenital cardiovascular disease

    • Principal Investigator
      YAMAGISHI Hiroyuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Keio University
  •  Development of induction protocol for cardiac field-specific cardiomyocytes and endocardial cells using human iPS cellsPrincipal Investigator

    • Principal Investigator
      KODO Kazuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Keio University
  •  Molecular mechanisms underlying development and interaction of progenitor cells essential for cardiac outflow tract morphogenesis

    • Principal Investigator
      YAMAGISHI Hiroyuki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Keio University
  •  molecular signaling mechanism via IP3 receptors in vascular endothelial cells in a state of pulmonary hypertensionPrincipal Investigator

    • Principal Investigator
      KODO Kazuki
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Keio University

All 2024 2023 2022 2021 2020 2019 2018 2017 2012 2011 2010

All Journal Article Presentation Book

  • [Book] 循環器疾患のサイエンス(小室一成編)2010

    • Author(s)
      山岸敬幸、古道一樹
    • Total Pages
      236
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-22390211
  • [Journal Article] The c.1617del variant of TMEM260 is identified as the most frequent single gene determinant for Japanese patients with a specific type of congenital heart disease2024

    • Author(s)
      Inoue Tadashi、Takase Ryuta、Uchida Keiko、Kodo Kazuki、Suda Kenji、Watanabe Yoriko、Yoshiura Koh-Ichiro、Kunimatsu Masaya、Ishizaki Reina、Azuma Kenko、Inai Kei、Muneuchi Jun、Furutani Yoshiyuki、Akagawa Hiroyuki、Yamagishi Hiroyuki
    • Journal Title

      Journal of Human Genetics

      Volume: 69 Issue: 5 Pages: 215-222

    • DOI

      10.1038/s10038-024-01225-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K07275, KAKENHI-PROJECT-23K24306, KAKENHI-PROJECT-23K27572
  • [Journal Article] Clinical Characteristics of Coronary-to-Pulmonary Artery Fistula in Patients with Pulmonary Atresia and Ventricular Septal Defect2023

    • Author(s)
      Sumitomo Naofumi F.、Kodo Kazuki、Inoue Tadashi、Oyanagi Takayuki、Yamagishi Hiroyuki
    • Journal Title

      Journal of Cardiovascular Development and Disease

      Volume: 10 Issue: 1 Pages: 17-17

    • DOI

      10.3390/jcdd10010017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K24306
  • [Journal Article] A genetic and developmental biological approach for a family with complex congenital heart diseases?evidence of digenic inheritance2023

    • Author(s)
      Yoshida Yu、Uchida Keiko、Kodo Kazuki、Ishizaki-Asami Reina、Maeda Jun、Katsumata Yoshinori、Yuasa Shinsuke、Fukuda Keiichi、Kosaki Kenjiro、Watanabe Yusuke、Nakagawa Osamu、Yamagishi Hiroyuki
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 10 Pages: 1135141-1135141

    • DOI

      10.3389/fcvm.2023.1135141

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K07275, KAKENHI-PROJECT-21H02890, KAKENHI-PROJECT-23K24061, KAKENHI-PROJECT-23K24306
  • [Journal Article] Genetic and functional analyses of TBX4 reveal novel mechanisms underlying pulmonary arterial hypertension2022

    • Author(s)
      Yoshida Yu、Uchida Keiko、Kodo Kazuki、Shibata Hironori、Furutani Yoshiyuki、Nakayama Tomotaka、Sakai Satoshi、Nakanishi Toshio、Takahashi Takao、Yamagishi Hiroyuki
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 171 Pages: 105-116

    • DOI

      10.1016/j.yjmcc.2022.07.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08267, KAKENHI-PROJECT-23K24306
  • [Journal Article] Successful Preoperative Partial Splenic Artery and Aneurysm Embolization for Thrombocytopenia Associated with Failed Fontan Circulation2022

    • Author(s)
      Sumitomo Naofumi F、Tamura Masashi、Asano Satoshi、Yuasa Erika、Oyanagi Takayuki、Inoue Masanori、Kodo Kazuki、Yamagishi Hiroyuki
    • Journal Title

      Int. Heart J.

      Volume: 63 Issue: 5 Pages: 984-988

    • DOI

      10.1536/ihj.22-083

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2022-09-30
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K24306
  • [Journal Article] Synthetic electrocardiogram-gated cardiac computed tomography precisely depicted a coronary-to-pulmonary fistula in an early infant with pulmonary atresia, ventricular septal defect, and major aortopulmonary collateral arteries.2022

    • Author(s)
      Sumitomo NF, Kodo K, Yamagishi H
    • Journal Title

      Eur Heart J Cardiovasc Imaging

      Volume: 23 Issue: 5 Pages: e236-e236

    • DOI

      10.1093/ehjci/jeab261

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03622
  • [Journal Article] Genetic and Cellular Interaction During Cardiovascular Development Implicated in Congenital Heart Diseases2021

    • Author(s)
      Kodo Kazuki、Uchida Keiko、Yamagishi Hiroyuki
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 8 Pages: 653244-653244

    • DOI

      10.3389/fcvm.2021.653244

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03622, KAKENHI-PROJECT-17K10153, KAKENHI-PROJECT-20K08267
  • [Journal Article] Echocardiographic Left Ventricular Z-Score Utility in Predicting Pulmonary-Systemic Flow Ratio in Children With Ventricular Septal Defect or Patent Ductus Arteriosus2021

    • Author(s)
      Sumitomo NF, Kodo K, Maeda J, Miura M, Yamagishi H
    • Journal Title

      Circ J

      Volume: 86 Issue: 1 Pages: 128-135

    • DOI

      10.1253/circj.CJ-21-0559

    • NAID

      130008132622

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2021-12-24
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03622
  • [Journal Article] A Temporo-Spatial Regulation of Sema3c Is Essential for Interaction of Progenitor Cells during Cardiac Outflow Tract Development2020

    • Author(s)
      Kodo Kazuki、Shibata Shinsuke、Miyagawa-Tomita Sachiko、Ong Sang-Ging、Takahashi Hiroshi、Kume Tsutomu、Okano Hideyuki、Matsuoka Rumiko、Yamagishi Hiroyuki
    • Journal Title

      Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

      Volume: - Pages: 377-379

    • DOI

      10.1007/978-981-15-1185-1_58

    • ISBN
      9789811511844, 9789811511851
    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03622
  • [Journal Article] Roles of Tbx4 in the Lung Mesenchyme for Airway and Vascular Development2020

    • Author(s)
      Uchida Keiko、Yoshida Yu、Kodo Kazuki、Yamagishi Hiroyuki
    • Journal Title

      Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

      Volume: - Pages: 79-81

    • DOI

      10.1007/978-981-15-1185-1_8

    • ISBN
      9789811511844, 9789811511851
    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03622
  • [Journal Article] Type 2 inositol 1,4,5-trisphosphate receptor inhibits the progression of pulmonary arterial hypertension via calcium signaling and apoptosis.2019

    • Author(s)
      Shibata A, Uchida K, Kodo K, Miyauchi T, Mikoshiba K, Takahashi T, Yamagishi H.
    • Journal Title

      Heart and Vessels

      Volume: 34 Issue: 4 Pages: 724-734

    • DOI

      10.1007/s00380-018-1304-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10153, KAKENHI-PROJECT-16H05359, KAKENHI-PROJECT-16K10074, KAKENHI-PROJECT-19H03622
  • [Journal Article] Polysplenia Syndrome as a Risk Factor for Early Progression of Pulmonary Hypertension2019

    • Author(s)
      Shibata A, Mori H, Kodo K, Nakanishi T, Yamagishi H.
    • Journal Title

      Circ J

      Volume: 83 Issue: 4 Pages: 831-836

    • DOI

      10.1253/circj.CJ-18-0933

    • NAID

      130007620474

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2019-03-25
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05359, KAKENHI-PROJECT-19H03622
  • [Journal Article] Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects.2012

    • Author(s)
      Kodo K, Nishizawa T, Furutani M, Arai S, Ishihara K, Oda M, Makino S, Fukuda K, Takahashi T, Matsuoka R, Nakanishi T, Yamagishi H.
    • Journal Title

      Circulation Journal

      Volume: 76 Pages: 1703-1711

    • NAID

      10030503588

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390211
  • [Journal Article] 心臓流出路発生における新たな分子メカニズムの解明 二次心臓領域と心臓神経堤の分子発生学2012

    • Author(s)
      古道一樹、山岸敬幸
    • Journal Title

      日本小児循環器学会雑誌

      Volume: 28 Pages: 206-210

    • NAID

      10031121943

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390211
  • [Journal Article] Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects2012

    • Author(s)
      Kodo K, Nishizawa T, Furutani M, Arai S, Ishihara K, Oda M, Makino S, FukudaK, Takahashi T, Matsuoka R, Nakanishi T, Yamagishi H.
    • Journal Title

      Circ J

      Volume: 76(7) Pages: 1703-1711

    • NAID

      10030503588

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390211
  • [Journal Article] Genetic Analysis of Essential Cardiac Transcription Factors in 256 Pati-ents with Non-Syndromic Congenital Heart Defects2012

    • Author(s)
      Kodo K, Yamagishi H, et al
    • Journal Title

      Circulation Journal

      Volume: (In press)

    • NAID

      10030503588

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390211
  • [Journal Article] A decade of advances in molecular embryology and genetics underlying congenital heart defects2011

    • Author(s)
      Kodo K, Yamagishi H
    • Journal Title

      Circulation Journal

      Volume: 75 Pages: 2296-2304

    • NAID

      10029458960

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390211
  • [Journal Article] Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field2011

    • Author(s)
      Nakazawa M, Uchida K, Aramaki M, Kodo K, Yamagishi C, Takahashi T, Mikoshiba K, Yamagishi H
    • Journal Title

      J Mol Cell Cardiol

      Volume: 51 Pages: 58-66

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390211
  • [Journal Article] A Decade of Advances in the Molecular Embryology and Genetics Underlying Congenital Heart Defects2011

    • Author(s)
      Kodo K, Yamagishi H
    • Journal Title

      Circ J

      Volume: 75 Issue: 10 Pages: 2296-2304

    • DOI

      10.1253/circj.CJ-11-0636

    • NAID

      10029458960

    • ISSN
      1346-9843, 1347-4820
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22791000
  • [Journal Article] A decade of advances in the molecular embryology and genetics underlying congenital heart defects2011

    • Author(s)
      Kodo K, Yamagishi H
    • Journal Title

      Circ J

      Volume: 75(10) Pages: 2296-304

    • NAID

      10029458960

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22791000
  • [Journal Article] Mechanisms underlying early development of pulmonary vascular obstructive disease in Down syndrome: An imbalance in biosynthesis of thromboxane A2 and prostacyclin2010

    • Author(s)
      Fukushima H, Kosaki K, Sato R, Yagihashi T, Gatayama R, Kodo K, Hayashi T, Nakazawa M, Tsuchihashi T, Maeda J, Kojima Y, Yamagishi H, Takahashi T
    • Journal Title

      Am J Med Genet A

      Volume: 152A Pages: 1919-1924

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390211
  • [Journal Article] GATA transcription factors in congenital heart defects2010

    • Author(s)
      Kodo K, Yamagishi H
    • Journal Title

      Journal of Human Genetics

      Volume: 55 Pages: 637-638

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390211
  • [Presentation] The c.1617del variant of TMEM260 is identified as the most frequent single gene determinant for persistent truncus arteriosus in Japanese population2024

    • Author(s)
      Tadashi Inoue, Keiko Uchida, Masaya Kunimatsu, Reina Ishizaki, Kazuki Kodo, Hiroyuki Yamagishi
    • Organizer
      Annual Meeting of the Association for European Pediatric and Congenital Cardiology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27572
  • [Presentation] The TMEM260 c.1617del variant is identified as the most frequent single gene determinant for persistent truncus arteriosus in Japanese population2024

    • Author(s)
      Tadashi Inoue, Ryuta Takase, Keiko Uchida, Kazuki Kodo, Kenji Suda, Yoriko Watanabe, Masaya Kunimatsu, Reina Ishizaki, Hiroyuki Akagawa, & Hiroyuki Yamagishi
    • Organizer
      JCK Asian Pacific Heart Forum
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27572
  • [Presentation] 日本人の総動脈幹遺残の病因の約2割を占める新たな遺伝子variantの発見2023

    • Author(s)
      井上忠、内田敬子、國松将也、石崎怜奈、古道一樹、山岸敬幸
    • Organizer
      第22回日本心臓血管発生研究会
    • Data Source
      KAKENHI-PROJECT-23K27572
  • [Presentation] iPS細胞を用いたヒト心臓発生異常の病因解明への挑戦2019

    • Author(s)
      古道 一樹
    • Organizer
      第122回日本小児科学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K10151
  • [Presentation] Patient specific iPS cell technology reveals abnormal activation of TGFβ signaling as a pathogenesis of left ventricular non-compaction cardiomyopathy2018

    • Author(s)
      古道 一樹
    • Organizer
      第95回日本生理学大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K10151
  • [Presentation] iPS技術を用いたヒト心筋発生研究と心筋疾患モデルへの応用2018

    • Author(s)
      古道 一樹
    • Organizer
      第27回日本小児心筋疾患学会学術集会(招待講演)
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K10151
  • [Presentation] iPS Cell Technology for Lifelong Cardiology in Developmental Defects of Myocardium2018

    • Author(s)
      古道 一樹
    • Organizer
      第82回日本循環器学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K10151
  • [Presentation] Study of Embryonic Myocardium Development using iPS Cells-Derived from Patients with Left Ventricular Non-compaction Cardiomyopathy2017

    • Author(s)
      古道 一樹
    • Organizer
      ConBio 2017
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K10151
  • [Presentation] A novel transcriptional cascade controlling the Semaphorin-Plexin signaling during heart development2011

    • Author(s)
      Kodo K, Yamagishi H, et al
    • Organizer
      Weinstein Cardiovascular Conference
    • Place of Presentation
      Cincinnati, USA
    • Year and Date
      2011-05-06
    • Data Source
      KAKENHI-PROJECT-22390211
  • [Presentation] Identification of Upstream Regulatory Mechanisms of Semaphorin 3c Signaling During the Development of the Outflow Tract2011

    • Author(s)
      Kodo K, Yamagishi H, et al
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-11-14
    • Data Source
      KAKENHI-PROJECT-22390211
  • [Presentation] Comprehensive genetic approach for congenital heart diseases revealed sequence variants in cardiac progenitor marker genes2010

    • Author(s)
      Kodo K, Yamagishi H, et al.
    • Organizer
      American Heart Association Scientific Session2010
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2010-11-17
    • Data Source
      KAKENHI-PROJECT-22390211
  • [Presentation] Comprehensive candidate approach for identification of sequence variant in cardiac transcription factors in patients with congenital heart defects2010

    • Author(s)
      Kodo K, Yamagishi H, et al.
    • Organizer
      Weinstein 2010 Cardiovascular Development Conference
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      2010-05-21
    • Data Source
      KAKENHI-PROJECT-22390211
  • 1.  YUASA Shinsuke (90398628)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  YAMAGISHI Hiroyuki (40255500)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 18 results
  • 3.  UCHIDA Keiko (50286522)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 4.  芝田 晋介 (70407089)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  TSUCHIHASHI Takatoshi (10286528)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  YAMAGISHI Chihiro (10296618)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 13 results
  • 7.  MAKINO Shinji (20306707)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  石崎 怜奈 (70528299)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 9.  菱木 貴子 (10338022)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  遠山 周吾 (90528192)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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