Shimizu Takeyuki 清水健之

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SHIMIZU Takeyuki 清水健之

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Researcher Number	10339137
Other IDs
Affiliation (Current)	2025: 高知大学, 教育研究部医療学系基礎医学部門, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 高知大学, 教育研究部医療学系基礎医学部門, 准教授 2011 – 2013: 高知大学, 教育研究部医療学系, 准教授 2010: Sapporo Medical University, 教育研究部・医療学系, 准教授 2006 – 2010: 札幌医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Functional biochemistry / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Respiratory organ internal medicine / Biological Sciences
Keywords	Principal Investigator 免疫学 / 腫瘍免疫 / ヘルパーT細胞 / 遺伝子 / miRNA / 血管内皮細胞 / 抗原提示 / T細胞 / がん免疫 / 体細胞突然変異 … More / 免疫記憶 / 抗原親和性 / 免疫応答成熟 / 抗体 / 免疫グロブリン / コレクチン / 生体分子 / 蛋白質 … More Except Principal Investigator SP-D / SP-A / コレクチン / MD-2 / マトリックスメタロプロテアーゼ / 肺サーファクタント蛋白質 / 細胞内寄生菌 / レジオネラ菌 / 非定型抗酸菌 / 肺コレクチン / endotoxin / pulmonary inflammation / Toll-like receptor / collectin / pulmonary surfactant / TLR4 / エンドトキシン / 肺炎症 / トル様受容体 / 肺サーファクタント / MMP / SP-C / 肺胞II型細胞 / 肺胞マクロファージ / メタロプロテアーゼ / 自然免疫 / 間質性肺炎 / 肺気腫 / 細菌貧食 / 細菌貪食 / マクロファージ Less

Analysis of endothelial cells presenting antigens to helper T cells in tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Shimizu Takeyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kochi University
Analysis of structural and functional changes in immunoglobulins during the maturation of the immune responsePrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kochi University
Mechanisms of host defense against pulmonaryinfection, inflammation and injury by surfactant proteins and studies on clinical applications
- Principal Investigator
  
  KUROKI Yoshio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Analysis of the interactions of collectins with immunoglobuins and the regulation immunoglobulin functionsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Sapporo Medical University
肺コレクチンを介するマクロファージ細菌貪食の分子機構
- Principal Investigator
  
  KUROKI Yoshio
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Surfactant protein regulates the activity of matrix metalloproteineses
- Principal Investigator
  
  MITSUZAWA Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Host defense system in the lung using pulmonary surfactant proteins and Toll-like reosptors
- Principal Investigator
  
  KUROKI Yoshio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University

All 2021 2020 2019 2018 2014 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Carboxylated polyamidoamine dendron-bearing lipid-based assemblies for precise control of intracellular fate of cargo and induction of antigen-specific immune responses.2020
- Author(s)
  Eiji Yuba , Yoshikatsu Sugahara, Yuta Yoshizaki, Takeyuki Shimizu, Michiyuki Kasai, Keiko Udaka, Kenji Kono
- Journal Title
  
  Biomater Sci
  
  Volume: 9 Issue: 8 Pages: 3076-3089
- DOI
  10.1039/d0bm01813a
- NAID
  120007026014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07775, KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-18K07299, KAKENHI-PROJECT-21H03822
[Journal Article] Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion2020
- Author(s)
  Toshihiro Komatsu, Takeyuki Shimizu, Makoto Kanoh, Tomoya Miyakawa, Yoko Satta, Yoshiki Yasukochi, Rika Fujimoto, Motoki Tada, Kaori Machida, Sayo Kataoka, Keiko Udaka
- Journal Title
  
  Immunogenetics
  
  Volume: 72 Issue: 3 Pages: 143-153
- DOI
  10.1007/s00251-020-01154-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07299, KAKENHI-PROJECT-19K07775, KAKENHI-PLANNED-16H06498
[Journal Article] High-affinity IgM+ memory B cells are defective in differentiation into IgM antibody-secreting cells by re-stimulation with a T cell-dependent antigen2018
- Author(s)
  Yasuyuki Tashiro, Akikazu Murakami, Yasuyoshi Hara, Takeyuki Shimizu, Masato Kubo, Ryo Goitsuka, Hidehiro Kishimoto, Takachika Azuma
- Journal Title
  
  Sci. Rep.
  
  Volume: 8 Issue: 1 Pages: 14559-14559
- DOI
  10.1038/s41598-018-32926-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07299, KAKENHI-PROJECT-16H05047
[Journal Article] Low affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten2014
- Author(s)
  Akikazu Murakami, Hayato Moriyama, Mina Osako-Kabasawa, Kanako Endo, Miyuki Nishimura, Keiko Udaka, Masamichi Muramatsu, Tasuku Honjo, Takachika Azuma, and Takeyuki Shimizu
- Journal Title
  
  Int. Immunol.
  
  Volume: 26 Issue: 4 Pages: 195-208
- DOI
  10.1093/intimm/dxt057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570169, KAKENHI-PROJECT-24790481
[Journal Article] In vivo role of aldehyde reductase2012
- Author(s)
  Motoko Takahashi
- Journal Title
  
  Bichim Biophys Acta
  
  Volume: 1820 Issue: 11 Pages: 1787-1796
- DOI
  10.1016/j.bbagen.2012.07.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590262, KAKENHI-PROJECT-23570169, KAKENHI-PROJECT-24591173
[Journal Article] Pulmonary collectins play distinct roles in host defense against Mycobacterium avium2011
- Author(s)
  Ariki S., Kojima T., Gasa S., 他8名
- Journal Title
  
  J. Immunol
  
  Volume: Vol.187 Issue: 5 Pages: 2586-2594
- DOI
  10.4049/jimmunol.1100024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790764, KAKENHI-PROJECT-23570169
[Journal Article] The amino acid residue at position 95 and the third CDR region in the H chain determine the ceiling affinity and the maturation pathway of an anti-(4-hydroxy-3-nitrophenyl) acetyl antibody2010
- Author(s)
  Akikazu Murakami, Yuka Takahashi, Miyuki Nishimura, Takeyuki Shimizu, Takachika Azuma.
- Journal Title
  
  Mol.Immunol. vol.48
  
  Pages: 48-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570136
[Journal Article] Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophlla and suppress its intracellular growth2010
- Author(s)
  Kaku Sawada, Shigeru Ariki, Takashi Kojima, Atsushi Saito, Masami Yamazoe, Chiaki Nishitani, Takeyuki Shimizu, Motoko Takahashi, Hiroaki Mitsuzawa, Shin-ichi Yokota, Norimasa Sawada, Nobuhiro Fujii, Hiroki Takahashi, Yoshio Kuroki.
- Journal Title
  
  J.Biol.Chem. vol.285
  
  Pages: 8434-8443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570136
[Journal Article] Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth.2010
- Author(s)
  Sawada K, Ariki S, Kojima T, Saito A, Yamazoe M, Nishitani C, Shimizu T, Takahashi M, Mitsuzawa H, Yokota SI, Sawada N, Fujii N, Takahashi H, Kuroki Y.
- Journal Title
  
  J Biol Chem vol285
  
  Pages: 8434-8443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390232
[Journal Article] Mutational analysis of Cys^<88> of Toll-like receptor 4 highlights the critical role of MD-2 in cell surface receptor expression2009
- Author(s)
  Chiaki Nishitani, Motoko Takahashi, Hiroaki Mitsuzawa, Takeyuki Shimizu, Shigeru Ariki, Norio Matsushima, Yoshio Kuroki.
- Journal Title
  
  Int.Immunol. vol.21
  
  Pages: 925-934
- NAID
  10025387642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570136
[Journal Article] Mutational analysis of Cys88 of Toll-like receptor 4 highlights the critical role of MD-2 in cell surface receptor expression.2009
- Author(s)
  Nishitani C, Takahashi M, Mitsuzawa H, Shimizu T, Ariki S, Matsushima N, Kuroki Y.
- Journal Title
  
  Int Immunol vol21
  
  Pages: 925-934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390232
[Journal Article] Mannose binding lectin and lung collectins interact with Toll-like receptor 4 and MD-2 by different mechanisms2009
- Author(s)
  Shimizu T
- Journal Title
  
  Biochim.Biophys.Acta 1790
  
  Pages: 1705-1711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390232
[Journal Article] Mannose binding lectin and lung collectins interact with Toll-like receptor 4 and MD-2 by different mechanisms2009
- Author(s)
  Shimizu T.
- Journal Title
  
  Biochim.Biophys.Acta. 1790
  
  Pages: 1705-1710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570136
[Journal Article] 肺コレクチンによるレジオネラ菌の増殖抑制2009
- Author(s)
  澤田格、有木茂、山添雅己、西谷千明、清水健之、高橋素子、横田伸一、藤井暢弘、高橋弘毅先生、黒木由夫
- Journal Title
  
  分子呼吸器病 13巻
  
  Pages: 117-119
- Data Source
  KAKENHI-PROJECT-20390232
[Journal Article] Mannose binding lectin and lung collectins interact with Toll-like receptor 4 and MD-2 by different mechanisms2009
- Author(s)
  Takeyuki Shimizu, Chiaki Nishitani, Hiroaki Mitsuzawa, Shigeru Ariki, Motoko Takahashi, Katsuki Ohtani, Nobutaka Wakamiya, Yoshio Kuroki.
- Journal Title
  
  Biochim.Biophys.Acta. vol.1790
  
  Pages: 1705-1710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570136
[Journal Article] Mnnose binding lectin and lung collectins interact with Toll-like receptor 4 and MD-2 by different mechanisms.2009
- Author(s)
  Shimizu T, Nishitani C, Mitsuzawa H, Ariki S, Takahashi M, Ohtani K, Wakamiya N, Kuroki Y.
- Journal Title
  
  Biochim biophys Acta vol1790
  
  Pages: 1705-1710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390232
[Journal Article] Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain2008
- Author(s)
  Xiaomeng Nie, Chiaki Nishitani, Masami Yamazoe, Shigeru Ariki, Motoko Takahashi, Takeyuki Shimizu, Hiroaki Mitsuzawa, Kaku Sawada, Kelly Smith, Erika Crouch, Hisato Nagae, Hiroki Takahashi, Yoshio Kuroki.
- Journal Title
  
  Biochemistry vol.47
  
  Pages: 12878-12885
- Data Source
  KAKENHI-PROJECT-20570136
[Journal Article] Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors.2008
- Author(s)
  Yamazoe M, Nishitani C, Takahashi M, Katoh T, Ariki S, Shimizu T, Mitsuzawa H, Sawada K, Voelker DR, Takahashi H, Kuroki Y.
- Journal Title
  
  J Biol Chem vol283
  
  Pages: 35878-35888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390232
[Journal Article] Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors2008
- Author(s)
  Masami Yamazoe, Chiaki Nishitani, Motoko Takahashi, Tsuyoshi Katoh, Shigeru Ariki, Takeyuki Shimizu, Hiroaki Mitsuzawa, Kaku Sawada, Dennis R.Voelker, Hiroki Takahashi, Yoshio Kuroki.
- Journal Title
  
  J.Biol.Chem. vol.283
  
  Pages: 35878-35888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570136
[Journal Article] Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain.2008
- Author(s)
  Nie X, Nishitani C, Yamazoe M, Ariki S, Takahashi M, Shimizu T, Mitsuzawa H, Sawada K, Smith K, Crouch E, Nagae H, Takahashi H, Kuroki Y.
- Journal Title
  
  Biochemistry vol47
  
  Pages: 12873-12855
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390232
[Journal Article] Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain2008
- Author(s)
  Nie X, Nishitani C, Yamazoe M, Ariki S, Takahashi M, Shimizu T, Mitsuzawa H, Sawada K, Smith K, Crouch E, Nagae H, Takahashi H, Kuroki Y
- Journal Title
  
  Biochemistry 47
  
  Pages: 12878-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590904
[Journal Article] The microtubule binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A J Biol Chem2007
- Author(s)
  Sano H, Ishino M, Kramer H, Shimizu T, Mitsuzawa H, Nishitani C, Kuroki Y
- Journal Title
  
  282
  
  Pages: 7973-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590904
[Journal Article] 6-Fluoro-8-methoxy-quinolone, gatifloxacin, downregulates IL-8 production in prostate cell line PC-32007
- Author(s)
  Takeyama K, Mitsuzawa H, Nishitani C, Shimizu T, Sano H, Kunishima Y, Takahashi S, Hotta H, Matsukawa M, Shibata K, Tsukamoto T, Kuroki Y
- Journal Title
  
  Antimicrob Agents Chemother 51(1)
  
  Pages: 162-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590904
[Presentation] Optimization of culture condition and method of detection to monitor T cells specific for HLA-peptides in PBMCs2021
- Author(s)
  Keiko Udaka, Asami Nakata, Kaori Machida, Toshihiko Komatsu, Takeyuki Shimizu
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07299
[Presentation] ゲノム編集によるTAP欠損細胞を使ったMHCクラスI分子と抗原ペプチドの結合相互作用解析法2019
- Author(s)
  清水健之、小松利広、深澤太郎、片岡佐誉、宇高恵子
- Organizer
  第23回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07299
[Presentation] Construction of a platform to predict HLA-A*11:01-binding peptides2019
- Author(s)
  小松利広、清水健之、町田香織、山下慶子、中村祥紀、宇高恵子
- Organizer
  第23回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07299
[Presentation] Construction of a computational platform to predict HLA-A*11:01 binding peptides2019
- Author(s)
  Keiko Udaka, Toshihiro Komatsu, Takeyuki Shimizu
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07299
[Presentation] Development of a novel monoclonal antibody which binds to most HLA-A allomorphs in a peptide-dependent, yet sequence promiscuous fashion2018
- Author(s)
  Makoto Kanoh, Takeyuki Shimizu, Toshihiro Komatsu, Yuko Satta, Sayo Kataoka, Keiko Udaka
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07299
[Presentation] B Lymphocyte Cadherin, BILLcadherin/cadherin-17, Contributes to the Survival of Memory B Cells2013
- Author(s)
  船越舟一、清水健之、大西一夫
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ（千葉県）
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] Germinal center reaction actively induces somatic hypermutation in IgM but down-regulates class switch recombination2013
- Author(s)
  田代泰之、原泰史、村上明一、清水健之、東隆親
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ（千葉県）
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] Germinal center reaction ac tively induces somatic hypermutation in IgM but down-regulates class switc h recombination2013
- Author(s)
  田代泰之, 原泰史, 村上明一, 清水健之, 東隆親.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2013-12-12
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] Detection of anti-(4-hydroxy-3-nitrophenyl)acetyl antibody secreting cells by cellular affinity matrix technology2013
- Author(s)
  清水健之、宇高恵子、東隆親
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ（千葉県）
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] B Ly mphocyte Cadherin, BILLcadherin/ cadh erin-17, Contributes to the Survival of Memory B Cells2013
- Author(s)
  船越舟一, 清水健之, 大西一夫.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2013-12-12
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] Detecti on of anti-(4-hydroxy-3-nitrophenyl) acetyl antibody secreting cells by ce llular affinity matrix technology2013
- Author(s)
  清水健之, 宇高恵子, 東隆親.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2013-12-12
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] Ganglioside合成酵素欠損マウスにおけるCD8, CD4 T細胞のin vivo機能の解析2012
- Author(s)
  佐野ほずみ, 清水健之, 福田絵美, 田中健一, 宇高恵子.
- Organizer
  第11回四国免疫フォーラム
- Place of Presentation
  高知大学(高知県)
- Year and Date
  2012-06-09
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] Flow cytometric identification of antigen-stimulated T cells by a meta bolic fluorescent probe2012
- Author(s)
  藤本理加, 清水健之, 片岡佐誉, 宇高恵子.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2012-12-06
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] Repertoire analysis of anti-(4-hydroxy-3-nitrophenyl)acetyl IgM antibodies produced in plasma cells2012
- Author(s)
  清水健之
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場・展示場（兵庫県）
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] Regulation of Late Stages of B Cell Differen tiation by BILL-cadherin/cadherin-172012
- Author(s)
  傅舟一, 清水健之, 大西一夫.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2012-12-07
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] Repertoire analysis of anti- (4-hyd roxy-3-nitrophenyl)acetyl IgM antibod ies produced in plasma cells2012
- Author(s)
  清水健之, 宇高恵子, 片岡佐誉, 東隆親.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2012-12-06
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] A minimal influence of glycosyl ation of ganglioside on the in vivo T h1-dominant responses in mouse2012
- Author(s)
  宇高恵子, 清水健之, 永福正和, 井ノ口仁一.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2012-12-06
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] マンノース結合レクチンとIgMの相互作用の解析2011
- Author(s)
  清水健之
- Organizer
  第10回四国免疫フォーラム
- Place of Presentation
  徳島大学（徳島県）
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] T細胞依存性免疫応答に関与するIgM+記憶B細胞の解析2011
- Author(s)
  原泰史, 村上明一, 西村深雪, 清水健之, 東隆親
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] マンノース結合レクチンとIgMの相互作用の多様性2011
- Author(s)
  清水健之
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ（千葉県）
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] マンノース結合レクチンとI gMの相互作用の解析2011
- Author(s)
  清水健之, 高橋素子, 西谷千明, 有木茂, 黒木由夫
- Organizer
  第10回四国免疫フォーラム
- Place of Presentation
  徳島大学(徳島県)
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] マンノース結合レクチンとI gMの相互作用の多様性2011
- Author(s)
  清水健之
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] Bリンパ球に発現するBILL-cadherin/ cadherin- 17は抗体の親和性維持に寄与する2011
- Author(s)
  傅舟一, 清水健之, 大西一夫.
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-23570169
[Presentation] Pulmonary collectins bind and agglutinate M. avium and attenuate its growth.2010
- Author(s)
  有木茂、賀佐伸省、小島隆、斎藤充史、西谷千明、高橋素子、清水健之、黒木由夫
- Organizer
  第83回日本生化学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] Oxidized surfactant lipids and oxidized PAPC inhibit LPS-induced inflammatory responses by different mechanisms.2010
- Author(s)
  西谷千明、有木茂、高橋素子、清水健之、栗村雄一郎, 斎藤充史、長谷川喜弘、黒木由夫
- Organizer
  第83回日本生化学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] コレクチンの免疫グロブリンに対する結合性の解析2010
- Author(s)
  清水健之
- Organizer
  第83回日本生化学会、第33回日本分子生物学会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-20570136
[Presentation] コレクチンの免疫グロブリンに対する結合性の解析2010
- Author(s)
  清水健之
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20570136
[Presentation] Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptor.2009
- Author(s)
  Nishitani C, Yamazoe M, Takahashi M, Kato T, Ariki S, Shimizu T, Sawada K, Voelker DR, Takahashi H, Kuroki Y
- Organizer
  Experimental Biology 2009
- Place of Presentation
  ニューオーリンズ
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] Roles of pulmonaru collectins in host defense against Legionella pneumophila infection.2009
- Author(s)
  Ariki S, Sawada K, Yamazoe M, Nishitani C, Shimizu T, Takahashi M, Yokota S, Fujii N, Kuroki Y
- Organizer
  Experimental Biology 2009
- Place of Presentation
  ニューオーリンズ
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] 非定型抗酸菌に対する肺コレクチンの生体防御機構2009
- Author(s)
  有木茂、澤田格、藤井暢弘、賀佐伸省、西谷千明、清水健之、山添雅己、高橋素子、黒木由夫
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] 肺サーファクタント脂質の酸化によるLPS惹起炎症性細胞応答の抑制2009
- Author(s)
  西谷千明、有木茂、清水健之、高橋素子、光澤博昭、黒木由夫
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] Pulmonary collectins interact with and aggregate Mycobacterium avium.2008
- Author(s)
  有木茂、澤田格、賀佐伸省、藤井暢弘、山添雅己、清水健之、西谷千明、高橋素子、黒木由夫
- Organizer
  第81回日本生化学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] 肺コレクチンは非定型抗酸菌に結合し菌体凝集を惹起する2008
- Author(s)
  有木茂、澤田格、賀佐伸省、藤井暢弘、山添雅己、清水健之、西谷千明、高橋素子、黒木由夫
- Organizer
  第19回日本生体防御学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] Pulmonary collectins interact with and aggregate Mycobacterium avium.2008
- Author(s)
  Ariki S, Sawada K, Gasa S, Fujii N, Yamazoe M, Shimizu T, Nishitani C, Takahashi M, Kuroki Y
- Organizer
  8^<th> Awaji International Forum on Infection and Immunity.
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] TLR4の細胞表面発現におけるMD-2の重要性2008
- Author(s)
  西谷千明、高橋素子、光澤博昭、清水健之、有木茂、松嶋範男、黒木由夫
- Organizer
  第19回日本生体防御学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] 肺サーファクタント蛋白質Dによるリポ多糖惹起炎症反応の抑制2008
- Author(s)
  山添雅己、有木茂、澤田格、西谷千明、清水健之、高橋素子、黒木由夫
- Organizer
  第19回日本生体防御学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] Mutational analysis of Cys88 of Toll-like receptor 4 highlights the critical role of MD-2 in cell surface receptor expression.2008
- Author(s)
  西谷千明、高橋素子、光澤博昭、清水健之、有木茂、松嶋範男、黒木由夫
- Organizer
  第81回日本生化学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] 肺コレクチンによるレジオネラ菌の増殖抑制2008
- Author(s)
  澤田格、有木茂、山添雅己、西谷千明、清水健之、高橋素子、横田伸一、藤井暢弘、高橋弘毅先生、黒木由夫
- Organizer
  第19回日本生体防御学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] The N-glycan on Asn418 regulates the ligand-binding kinetics of ErbB3.2008
- Author(s)
  高橋素子、横江俊一、有木茂、西谷千明、清水健之、黒木由夫
- Organizer
  第81回日本生化学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] Pulmonary collectins exhibit bactericidal activity against Legionella pneumophila.2008
- Author(s)
  Sawada K, Ariki S, Yamazoe M, Nishitani C, Shimizu T, Takahashi M, Yokota SI, Fujii N, Takahashi H, Kuroki Y
- Organizer
  8^<th> Awaji International Forum on Infection and Immunity.
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] Pulmonary collectins exhibit anti-microbial activity against legionella pneumophila.2008
- Author(s)
  澤田格、有木茂、山添雅己、西谷千明、清水健之、高橋素子、横田伸一、藤井暢弘、高橋弘毅、黒木由夫
- Organizer
  第81回日本生化学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20390232
[Presentation] Lung collectins and mannose binding lectin interact weth Toll-like receptors by different mechanisms2007
- Author(s)
  Shimizu T.
- Organizer
  第80回日本生化学会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-19041062
[Presentation] Lung collectins and mannose binding lectin interact with Toll-like receptors by different mechanisms2007
- Author(s)
  Shimizu T
- Organizer
  第80回日本生化学会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390241
[Presentation] Lung collectins and mannose binding lectin interact with Toll-like receptors by different mechanisms.2007
- Author(s)
  Shimizu T
- Organizer
  第80回日本生化学会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18390241
[Presentation] Lung collectins and mannose binding lectin interact with Toll-like receptors by different mechanism2007
- Author(s)
  Shimizu, T
- Organizer
  The 80th Japan Biochemistry Society Meeting
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390241

1. NISHITANI Chiaki (30381255)

# of Collaborated Projects: 5 results

# of Collaborated Products: 30 results
2. KUROKI Yoshio (70161784)

# of Collaborated Projects: 5 results

# of Collaborated Products: 30 results
3. TAKAHASHI Motoko (00303941)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
4. MITSUZAWA Hiroaki (40325874)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. ARIKI Shigeru (80464478)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
6. TAKAHASHI Hiroki (60231396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 宇高恵子 (40263066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. 小松利広 (90598517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. 光沢博昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Shimizu Takeyuki 清水 健之

SHIMIZU Takeyuki 清水 健之

Research Projects

Research Products

Co-Researchers

Analysis of endothelial cells presenting antigens to helper T cells in tumor microenvironmentPrincipal Investigator

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Analysis of structural and functional changes in immunoglobulins during the maturation of the immune responsePrincipal Investigator

Principal Investigator

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Mechanisms of host defense against pulmonaryinfection, inflammation and injury by surfactant proteins and studies on clinical applications

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Analysis of the interactions of collectins with immunoglobuins and the regulation immunoglobulin functionsPrincipal Investigator

Principal Investigator

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肺コレクチンを介するマクロファージ細菌貪食の分子機構

Principal Investigator

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Review Section

Research Institution

Surfactant protein regulates the activity of matrix metalloproteineses

Principal Investigator

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Host defense system in the lung using pulmonary surfactant proteins and Toll-like reosptors

Principal Investigator

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Research Institution

[Journal Article] Carboxylated polyamidoamine dendron-bearing lipid-based assemblies for precise control of intracellular fate of cargo and induction of antigen-specific immune responses.2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-affinity IgM+ memory B cells are defective in differentiation into IgM antibody-secreting cells by re-stimulation with a T cell-dependent antigen2018

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DOI

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[Journal Article] Low affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten2014

Author(s)

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DOI

Data Source

[Journal Article] In vivo role of aldehyde reductase2012

Author(s)

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DOI

Data Source

[Journal Article] Pulmonary collectins play distinct roles in host defense against Mycobacterium avium2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The amino acid residue at position 95 and the third CDR region in the H chain determine the ceiling affinity and the maturation pathway of an anti-(4-hydroxy-3-nitrophenyl) acetyl antibody2010

Author(s)

Shimizu Takeyuki 清水健之

SHIMIZU Takeyuki 清水健之