kitajima kenji 北島健二

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KITAJIMA Kenji 北島健二

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Researcher Number	10346132
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 主席研究員 2025: 公益財団法人東京都医学総合研究所, 先端基礎医科学研究分野, 主席研究員
Affiliation (based on the past Project Information) *help	2016 – 2019: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 2012 – 2014: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 2011: 財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 2010: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主任研究員 2009: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 主任研究員 … More 2008: 大阪大学, 医学系・研究科, 特任准教授(常勤) 2007 – 2008: Osaka University, 医学系研究科, 特任准教授(常勤) 2005 – 2006: Osaka University, Graduate School of Medicine, Specially appointed Associate Professor, 医学系研究科, 特任助教授(常勤) 2004: 大阪大学, 微生物病研究所, 助手 Less
Review Section/Research Field	Principal Investigator Hematology / Biological Sciences Except Principal Investigator Medical genome science / Hematology / Experimental pathology
Keywords	Principal Investigator 細胞分化 / 転写因子 / 血液細胞 / ES細胞 / 幹細胞 / 造血幹細胞 / エピジェネティックス / 巨核球 / 胚性幹細胞 / 赤血球 … More / エピジェネティック / 再生医学 / 発生・分化 / 炎症性サイトカイン / 分化誘導 / インターフェロン / Lineage switch / Transcription factor / Embryonic stem cells / Differentiation / Hematopoiesis / 分子生物学 / クロマチン構造 / マクロファージ / 血液 / 分化転換 / 再生医療 / 試験管内分化誘導 / ホメオボックス / iPS細胞 / エピジェネティクス / 血液内科学 / エリスロポエチン / 自己複製 / 分化多能性 … More Except Principal Investigator 造血幹細胞 / ES細胞 / 造血発生 / 転写因子 / iPS細胞 / 急性骨髄性白血病 / Lhx2 / CMG-1 / CXCL12 / ES細胞分化 / CXCL14 / ニッチ / 骨髄ニッチ / 生殖幹細胞 / 毛包幹細胞 / 上皮幹細胞 / GSK3β / 間葉系幹細胞 / 軟骨 / 幹細胞 / Akt / 初期化 / 脱分化 / 生殖細胞 / 胚性幹細胞 / 組織幹細胞 / シグナル伝達 / リン酸化酵素 / 幹細胞システム Less

Induction of hematopoietic stem cells from mouse embryonic stem cells by inflammatory cytokinesPrincipal Investigator
- Principal Investigator
  
  KITAJIMA Kenji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Investigation of developmental regulators for human hematopoietic stem cells and downstream road-blocker(s) of Lhx2
- Principal Investigator
  
  HARA Takahiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical genome science
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Development of novel differentiation induction system of hematopoietic stem cells from human induced pluripotent stem cellsPrincipal Investigator
- Principal Investigator
  
  KITAJIMA Kenji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Characterization and exploration of bone marrow niche regulators for hematopoietic stem cells
- Principal Investigator
  
  HARA Takahiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Establishment of epigenetic pattern during cell differentiationPrincipal Investigator
- Principal Investigator
  
  KITAJIMA Kenji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research
血液細胞の分化多能性・自己複製能を制御するデコード回路の解明Principal Investigator
- Principal Investigator
  
  北島健二
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
  Osaka University
Roles of phosphorylation signals in regulation of stem cell systems
- Principal Investigator
  
  KIMURA Tohru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Osaka University
A study of molecular mechanisms underlying the irreversibility of hematopoieticdifferentiationPrincipal Investigator
- Principal Investigator
  
  KITAJIMA Kenji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
転写因子制御による血液細胞の増幅とその利用Principal Investigator
- Principal Investigator
  
  北島健二
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Hematopoietic lineage determination by transcription factors.Principal Investigator
- Principal Investigator
  
  KITAJIMA Kenji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University

[Journal Article] Nitric Oxide and a Conditioned Medium Affect the Hematopoietic Development in a Microfluidic Mouse Embryonic Stem Cell/OP9 Co-Cultivation System2020
- Author(s)
  Sato Kae、Maeda Momoko、Kamata Eriko、Ishii Sayaka、Yanagisawa Kanako、Kitajima Kenji、Hara Takahiko
- Journal Title
  
  Micromachines
  
  Volume: 11 Issue: 3 Pages: 305-305
- DOI
  10.3390/mi11030305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09911
[Journal Article] In vitro differentiation of mouse T cell-derived hybrid cells obtained through cell fusion with embryonic stem cells2019
- Author(s)
  Nakajima Marino、Suzuki Teruhiko、Hara Takahiko、Kitajima Kenji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 513 Issue: 3 Pages: 701-707
- DOI
  10.1016/j.bbrc.2019.04.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09911
[Journal Article] Inhibitory action of an ERK1/2 inhibitor on primitive endoderm cell differentiation from mouse embryonic stem cells.2019
- Author(s)
  H. Tabata, T. Hara, and K. Kitajima.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 512 Issue: 2 Pages: 399-404
- DOI
  10.1016/j.bbrc.2019.03.081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04728, KAKENHI-PROJECT-17K09911
[Journal Article] Domain-specific biological functions of the transcription factor Gata2 on hematopoietic differentiation of mouse embryonic stem cells2018
- Author(s)
  Kitajima Kenji、Kanokoda Mai、Nakajima Marino、Hara Takahiko
- Journal Title
  
  Genes to Cells
  
  Volume: 23 Issue: 9 Pages: 753-766
- DOI
  10.1111/gtc.12628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09911, KAKENHI-PROJECT-16H04728
[Journal Article] Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels2018
- Author(s)
  Miyashita Kazuya、Kitajima Kenji、Goyama Susumu、Kitamura Toshio、Hara Takahiko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 3 Pages: 2310-2316
- DOI
  10.1016/j.bbrc.2017.12.135
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09911, KAKENHI-PROJECT-16H04728
[Journal Article] Efficient production of platelets from mouse embryonic stem cells by enforced expression of Gata2 in late hemogenic endothelial cells.2016
- Author(s)
  M. Kawaguchi, K. Kitajima, M. Kanokoda, H. Suzuki, K. Miyashita, M. Nakajima, H. Nuriya, K. Kasahara, and T. Hara.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 474 Issue: 3 Pages: 462-468
- DOI
  10.1016/j.bbrc.2016.04.140
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04728
[Journal Article] LIM homeobox transcription factor Lhx2 inhibits skeletal muscle differentiation in part via transcriptional activation of Msx1 and Msx2.2015
- Author(s)
  Kodaka Y, Tanaka K, Kitajima K, Tanegashima K, Matsuda R, Hara T.
- Journal Title
  
  Exp Cell Res
  
  Volume: 331 Pages: 309-319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591415
[Journal Article] Endothelial cell-specific expression of roundabout 4 is regulated by differential DNA methylation of the proximal promoter.2014
- Author(s)
  Okada Y, Funahashi N, Tanaka T, Nishiyama Y, Yuan L, Shirakura K, Turjman AS, Kano Y, Naruse H, Suzuki A, Sakai M, Zhixia J, Kitajima K, Ishimoto K, Hino N, Kondoh M, Mukai Y, Nakagawa S, Garcia-Cardena G, Aird WC, Doi T.
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 34 Pages: 1531-1538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591415
[Journal Article] Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic progenitor cells derived from mouse embryonic stem cells2013
- Author(s)
  K. Kitajima, M. Kawaguchi, M. Iacovino, M. Kyba, and T. Hara
- Journal Title
  
  Stem Cells
  
  Volume: 31 Pages: 2680-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390256
[Journal Article] Tumor suppressive function of PTPN23 in testicular germ cell tumors is lost upon overexpression of miR-142-3p2013
- Author(s)
  Kiyoko Tanaka
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: - Issue: 33 Pages: 23990-23999
- DOI
  10.1074/jbc.m113.478891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592356, KAKENHI-PROJECT-24591415, KAKENHI-PROJECT-25462495
[Journal Article] Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic progenitor cells derived from mouse embryonic stem cells.2013
- Author(s)
  K. Kitajima, M. Kawaguchi, M. Iacovino, M. Kyba, and T. Hara
- Journal Title
  
  Stem Cells
  
  Volume: 31 Issue: 12 Pages: 2680-2689
- DOI
  10.1002/stem.1500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390256, KAKENHI-PROJECT-24591415
[Journal Article] ES細胞・iPS細胞から機能的な血液細胞を作り出す方法2012
- Author(s)
  原　孝彦, 北島健二
- Journal Title
  
  実験医学
  
  Volume: 30（増刊号） Pages: 1671-1676
- Data Source
  KAKENHI-PROJECT-23390256
[Journal Article] ES細胞・iPS細胞から機能的な血液細胞を作り出す方法．2012
- Author(s)
  原孝彦，北島健二
- Journal Title
  
  実験医学
  
  Volume: 30 Pages: 1671-1676
- Data Source
  KAKENHI-PROJECT-24591415
[Journal Article] ES細胞・iPS細胞から機能的な血液細胞を作り出す方法2012
- Author(s)
  原孝彦, 北島健二
- Journal Title
  
  実験医学(増刊号)
  
  Volume: 30 Pages: 1671-1676
- Data Source
  KAKENHI-PROJECT-23390256
[Journal Article] Embryonic stem cell differentiation system for evaluating gene functions involved in physiological megakaryocytic differentiation.2012
- Author(s)
  Okada Y, Yonekura M, Watanabe M, Nakai T, Wakimura A, Shimizu M, Kamikawa Y, Kitayama M, Kitajima K, Aird WC, Doi T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 419 Pages: 477-481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591415
[Journal Article] Multiple ETS Family Proteins Regulate PF4 Gene Expression by Binding to the Same ETS Binding Site2011
- Author(s)
  Okada Y, Nobori H, Shimizu M, Watanabe M, Yonekura M, Nakai T, Kamikawa Y, Wakimura A, Funahashi N, Naruse H, Watanabe A, Yamasaki D, Fukada S, Yasui K, Matsumoto K, Sato T, Kitajima K, Nakano T, Aird WC, Doi T
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591204
[Journal Article] iPS細胞から造血幹細胞の誘導2011
- Author(s)
  北島健二,原孝彦
- Journal Title
  
  医学のあゆみ
  
  Volume: 239 Pages: 1397-401
- Data Source
  KAKENHI-PROJECT-21591204
[Journal Article] In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx22011
- Author(s)
  Kitajima K, Minehata K, Sakimura K, Nakano T, Hara T
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 3748-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591204
[Journal Article] In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx22011
- Author(s)
  K.Kitajima, K.Minehata, K.Sakimura, T.Nakano, T.Hara
- Journal Title
  
  Blood
  
  Volume: 117 Issue: 14 Pages: 3748-3758
- DOI
  10.1182/blood-2010-07-298596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390256
[Journal Article] In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx22011
- Author(s)
  Kitajima K
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 3748-3758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591204
[Journal Article] iPS細胞から造血幹細胞の誘導2011
- Author(s)
  北島健二
- Journal Title
  
  医学のあゆみ
  
  Volume: 239 Pages: 1397-1401
- Data Source
  KAKENHI-PROJECT-21591204
[Journal Article] iPS細胞から造血幹細胞への分化誘導2011
- Author(s)
  北島健二、原孝彦
- Journal Title
  
  医学のあゆみ(増刊号)
  
  Volume: 239 Pages: 1397-1401
- Data Source
  KAKENHI-PROJECT-23390256
[Journal Article] Disabled-2 is required for mesoderm differentiation of murine embryonic stem cells2010
- Author(s)
  Huang C, Cheng J, Kitajima K, Nakano T, Yeh C, Chong K, Tseng C
- Journal Title
  
  J Cell Physiol
  
  Volume: 225 Pages: 92-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591204
[Journal Article] Novel role for the intraflagellar transport protein CMG-1 in regulating the transcription of cyclin-D2, E-cadherin and integrin-alpha family genes in mouse spermatocyte-derived cells2010
- Author(s)
  Ohbayashi K, Tanaka K, Kitajima K, Tamura K, Hara T
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 699-710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591204
[Journal Article] Increase of hematopoietic progenitor and suppression of endothelial gene expression by Runxl expression during in vitro ES differentiation2009
- Author(s)
  Sakai E, Kitajima K, Sato A, Nakano T
- Journal Title
  
  Exp Hematol 37
  
  Pages: 34-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591111
[Journal Article] Calyculin A retraction of mature megakaryocytes proplatelets from embryonic stem cells2009
- Author(s)
  Tamaru S, Kitajima K, Nakano T, Eto K, Yazaki A, Kobayashi T, Matsumoto T, Wada H, Katayama N, Nishikawa M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 366 Pages: 763-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591204
[Journal Article] Calyculin A retraction of mature megakaryocytes proplatelets from embryonic stem cells2009
- Author(s)
  Tamaru S, Kitajima K, Nakano T, Eto K, Yazaki A, Kobayashi T, Matsumoto T, Wada H, Katayama N, Nishikawa M.
- Journal Title
  
  Biochem Biophys Res Commun 366
  
  Pages: 763-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591111
[Journal Article] Increase of hematopoietic progenitor and suppression of endothelial gene expression by Runx1 expression during in vitro ES differentiation2009
- Author(s)
  Sakai E, Kitajima K, Sato A, Nakano T
- Journal Title
  
  Exp Hematol
  
  Volume: 37 Pages: 334-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591204
[Journal Article] Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation.2008
- Author(s)
  Sugiyama D, Tanaka M, Kitajima K, Zheng J, Yen H, Murotani T, Yamatodani A, Nakano T
- Journal Title
  
  Blood 111
  
  Pages: 1924-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591111
[Journal Article] 赤血球・巨核球造血における転写因子ネットワーク2007
- Author(s)
  北島健二
- Journal Title
  
  実験医学 25
  
  Pages: 1554-1561
- Data Source
  KAKENHI-PROJECT-19591111
[Journal Article] Efficient derivation of embryonic stem cells by inhibition of glycogen synthase kinase 32007
- Author(s)
  Umehara H, Kimura T, Ohtsuka S, Nakamura T, Kitajima K, Ikawa M, Okabe M, Niwa H, and Nakano T.
- Journal Title
  
  Stem Cells 25(11)
  
  Pages: 2705-2711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390113
[Journal Article] Efficient derivation of embryonic stem cells by inhibition of glycogen synthase kinase-32007
- Author(s)
  Umehara H, Kimura T, Ohtsuka S, Nakamura T, Kitajima K, Ikawa M, Okabe M, Niwa H, Nakano T
- Journal Title
  
  Stem Cells 25
  
  Pages: 2705-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591111
[Journal Article] Redirecting differentiation of hematopoietic progenitors by a transcription factor GATA-22006
- Author(s)
  Kitajima K
- Journal Title
  
  Blood 107
  
  Pages: 1857-1863
- Data Source
  KAKENHI-PROJECT-18055020
[Journal Article] Multipotential differentiation ability of GATA-1-null erythroid-committed cells2006
- Author(s)
  Kitajima K
- Journal Title
  
  Genes ＆ Development 20
  
  Pages: 654-659
- Data Source
  KAKENHI-PROJECT-18055020
[Journal Article] Redirecting differentiation of hematopoietic progenitors by a transcription factor GATA-2.2006
- Author(s)
  Kitajima K
- Journal Title
  
  Blood 107
  
  Pages: 1857-1863
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590939
[Journal Article] Multpotential differentiation ability of GATA-1-null erythroid-committed cells.2006
- Author(s)
  Kitajima K.
- Journal Title
  
  Genes Dev 20
  
  Pages: 654-659
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590939
[Journal Article] Redirecting differentiation of hematopoietic progenitors by a transcription factor GATA-2.2006
- Author(s)
  Kitajima K.
- Journal Title
  
  Blood 107
  
  Pages: 1857-1863
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590939
[Journal Article] Multipotential differentiation ability of GATA-1 null erythroid committed cells.2006
- Author(s)
  Kitajima K
- Journal Title
  
  Genes & Development 20
  
  Pages: 654-659
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590939
[Journal Article] Multipotential differentiation ability of GATA-1 null erythroid committed cells.
- Author(s)
  Kenji Kitajima
- Journal Title
  
  Genes & Development in press
- Data Source
  KAKENHI-PROJECT-16590939
[Journal Article] Redirecting differentiation of hematopoietic progenitors by a transcription factor GATA-2.
- Author(s)
  Kenji Kitajima
- Journal Title
  
  Blood in press
- Data Source
  KAKENHI-PROJECT-16590939
[Presentation] 転写因子Gata4によるマウスES細胞から原始内胚葉系細胞への分化誘導メカニズム.2018
- Author(s)
  田畑陽美, 北島健二, 原孝彦.
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H04728
[Presentation] 転写因子Gata4によるマウスES細胞から原始内胚葉系細胞への分化誘導メカニズム。2018
- Author(s)
  田畑陽美、原孝彦、北島健二
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09911
[Presentation] 転写因子Gata2の赤血球・巨核球誘導ドメインの同定。2018
- Author(s)
  北島健二、原孝彦
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09911
[Presentation] 転写因子Gata2の赤血球巨核球誘導ドメインの同定.2018
- Author(s)
  北島健二, 原孝彦.
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H04728
[Presentation] ヒトiPS細胞の血液細胞分化に対するLIMホメオドメイン転写因子Lhx2の機能.2017
- Author(s)
  *高橋佑奈、北島健二、原孝彦
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-17K09911
[Presentation] マウスES細胞から血液細胞への分化における転写因子Gata2のドメイン特異的な機能.2017
- Author(s)
  北島健二, 鹿子田真衣, 原孝彦.
- Organizer
  第40回日本分子生物学会年会ConBio2017
- Data Source
  KAKENHI-PROJECT-16H04728
[Presentation] マウスES細胞から血液細胞への分化における転写因子Gata2のドメイン特異的な機能.2017
- Author(s)
  *北島健二、鹿子田真衣、原孝彦
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-17K09911
[Presentation] ヒトiPS細胞の血液細胞分化に対するLIMホメオドメイン転写因子Lhx2の機能.2017
- Author(s)
  高橋佑奈, 北島健二, 原孝彦.
- Organizer
  第40回日本分子生物学会年会ConBio2017
- Data Source
  KAKENHI-PROJECT-16H04728
[Presentation] Growth Suppressing Activity of Lhx2 in Human T Cell Acute Lymphoblastic Leukemia (T-ALL)-derived Cells and Large-scale Screening of Lead Compounds Targeting T-ALL.2016
- Author(s)
  K. Miyashita, N. Kagaya, M. Izumikawa, K. Kitajima, K. Watakabe-Inamoto, Y. Najima, N. Doki, T. Kobayashi, K. Kakihana, S. Goyama, T. Kitamura, K. Ohashi, K. Shin-ya, and T. Hara.
- Organizer
  58th ASH (American Society of Hematology) Annual Meeting and Exposition
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04728
[Presentation] 転写因子Lhx2による多能性幹細胞から長期骨髄再建能を有する造血幹細胞様細胞への誘導2014
- Author(s)
  北島健二，川口真実，宮下和也，鹿子田真衣，中島　鞠乃，原孝彦.
- Organizer
  第 37 回・日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜　（神奈川県・横浜市）
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-24591415
[Presentation] 転写制御因子Lhx2は急性Tリンパ芽球性白血病細胞の増殖を抑制する2013
- Author(s)
  宮下和也，北島健二，原孝彦
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24591415
[Presentation] In vitro induction of HSC-like cells from mouse ESCs/iPSCs by a transcription factor Lhx22013
- Author(s)
  *K. Kitajima, M. Kawaguchi, K. Miyashita, and T. Hara
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] 転写制御因子 Lhx2 は急性 T リンパ芽球性白血病細胞の増殖を抑制する.2013
- Author(s)
  宮下和也, 北島健二, 原　孝彦
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Gata2 はhemogenic endothelial cells からの血液細胞出芽を促進する2013
- Author(s)
  川口真実, 北島健二, 原孝彦
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Molecular mechanisms of the Lhx2-mediated generation of hematopoietic stem cell-like cells from murine ES/iPS cells2013
- Author(s)
  K. Kitajima, M. Kawaguchi, K. Miyashita, M. Iacovino, M. Kyba, and *T. Hara
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Lhx2 は筋脱分化因子 Msx1, Msx2 の発現を制御する.2013
- Author(s)
  小高悠作, 田中貴代子, 北島健二, 松田良一, 原　孝彦
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] In vitro induction of HSC-like cells from mouse ESCs/iPSCs by a transcription factor Lhx22013
- Author(s)
  Kitajima K, Kawaguchi M, Miyashita K, Hara T
- Organizer
  The 75th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24591415
[Presentation] Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic stem-like cell differentiation from mouse embryonic stem cells.2013
- Author(s)
  ○K. Kitajima, M. Kawaguchi, M. Iacovino, M. Kyba, and T. Hara
- Organizer
  第11回幹細胞シンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Gata2 は hemogenic endothelial cells からの血液細胞出芽を促進する.2013
- Author(s)
  川口真実, 北島健二, 原　孝彦
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Lhx2は筋脱分化因子Msx1, Msx2の発現を制御する2013
- Author(s)
  小高悠作，田中貴代子，北島健二，松田良一，原孝彦
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24591415
[Presentation] Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic stem-like cell differentiation from mouse embryonic stem cells2013
- Author(s)
  *K. Kitajima, M. Kawaguchi, M. Iacovino, M. Kyba, and T. Hara
- Organizer
  第11回幹細胞シンポジウム
- Place of Presentation
  本郷
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Molecular mechanisms of the Lhx2-mediated generation of HSC-like cells from embryonic stem cells2013
- Author(s)
  K. Kitajima, M. Kawaguchi, K. Miyashita, M. Iacovino, M. Kyba, and *T. Hara
- Organizer
  2nd IGAKUKEN International Symposium on Hematopoietic Stem Cell Development
- Place of Presentation
  Tokyo
- Year and Date
  2013-02-08
- Invited
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic stem-like cell differentiation from mouse embryonic stem cells2013
- Author(s)
  Kitajima K, Kawaguchi M, Iacovino M, Kyba M, Hara T
- Organizer
  The 11th Stem Cell Research Sympojium
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591415
[Presentation] Molecular mechanisms of the Lhx2-mediated generation of hematopoietic stem cell-like cells from murine ES/iPS cells.2013
- Author(s)
  K. Kitajima, M. Kawaguchi, K. Miyashita, M. Iacovino, M. Kyba, ○T. Hara
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic stemlike cell differentiation from mouse embryonic stem cells.2013
- Author(s)
  Kitajima K, Kawaguchi M, Iacovino M, Kyba M, Hara T.
- Organizer
  The 11th Stem Cell Research Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-24591415
[Presentation] Gata2はhemogenic endothelial cells からの血液細胞出芽を促進する2013
- Author(s)
  川口真実，北島健二，原孝彦
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24591415
[Presentation] 転写制御因子Lhx2は急性Tリンパ芽球性白血病細胞の増殖を抑制する2013
- Author(s)
  宮下和也, 北島健二, 原孝彦
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Enforced expression of Lhx2 enhances the differentiation of CD41+ hematopoietic precursors from mouse ES cells.2012
- Author(s)
  Kawaguchi M, Kitajima K, Kyba M, Hara T.
- Organizer
  The 35th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Fukuoka
- Data Source
  KAKENHI-PROJECT-24591415
[Presentation] Underlying mechanisms of the in vitro induction of hematopoietic stem cell-like cells from mouse embryonic stem cells by LIM-homeobox transcription factor, Lhx2.2012
- Author(s)
  Kitajima K, Kyba M, Hara T.
- Organizer
  International Society for Stem Cell Research 10th Annual Meeting
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-24591415
[Presentation] Underlying mechanisms of the in vitro induction of hematopoietic stem cell-like cells from mouse embryonic stem cells by Lim-homeobox transcription factor, Lhx22012
- Author(s)
  K. Kitajima, M. Kyba, and T. Hara
- Organizer
  10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Induction of hematopoietic stem-like cells from mouse pluripotent stem cells by LIM-homeobox transcription factor Lhx2.2012
- Author(s)
  Kitajima K, Kawaguchi M, Momiyama K, Kyba M, Hara T.
- Organizer
  The 35th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Fukuoka
- Invited
- Data Source
  KAKENHI-PROJECT-24591415
[Presentation] 転写因子Lhx2によるマウス多能性幹細胞から造血幹細胞への分化誘導2012
- Author(s)
  北島健二, 川口真実, 籾山和沙, Michael Kyba, 原孝彦
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] 転写因子Lhx2の強制発現はマウスES細胞からの原始造血前駆細胞分化を促進する2012
- Author(s)
  川口真実, 北島健二, M. Kyba, 原孝彦
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Induction of hematopoietic stem-like cells from mouse pluripotent stem cells by LIM-homeobox transcription factor Lhx22012
- Author(s)
  *北島健二, 川口真実, 籾山和沙, M. Kyba, 原孝彦
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Underlying mechanisms of the in vitro induction of hematopoietic stem cell-like cells from mouse embryonic stem cells by Lim-homeobox transcription factor, Lhx2.2012
- Author(s)
  K. Kitajima, M. Kyba, and T. Hara
- Organizer
  10th Annual Meeting of International Society for Stem Cell Research
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Effects of ectopic expression of LIM-homeobox transcription factor lhx2 on in vitro differentiation of ESCs/iPSCs2011
- Author(s)
  北島健二, 原孝彦
- Organizer
  第44回日本発生生物学会年会
- Place of Presentation
  宜野湾
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Effects of ectopic expression of LIM-homeobox transcription factor lhx2 on in vitro differentiation of ESCs/iPSCs2011
- Author(s)
  Kitajima K, Hara T
- Organizer
  44th Annual Meeting of the Japanese Society of Developmental Biologists
- Place of Presentation
  Ginowan
- Data Source
  KAKENHI-PROJECT-21591204
[Presentation] In vivo analyses of mouse iPSC-derived HSC-like cells generated by enforced expression of LIM-homeobox transcription factor Lhx22011
- Author(s)
  Kitajima K, Hara T
- Organizer
  The 9th Stem Cell Research Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-21591204
[Presentation] In vivo analyses of mouse iPSC-derived HSC-like cells generated by enforced expression of LIM-homeobox transcription factor Lhx22011
- Author(s)
  K.Kitajima, T.Hara
- Organizer
  第9回幹細胞シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] FoxO1 is required for hemangioblast development in mice2011
- Author(s)
  K.Minehata, K.Kitajima, M.Kyba, T.Hara
- Organizer
  第9回幹細胞シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] In vivo analyses of mouse iPSC-derived HSC-like cells generated by enforced expression of LIM-homeobox transcription factor Lhx22011
- Author(s)
  K. Kitajima and T. Hara
- Organizer
  第9回幹細胞シンポジウム
- Place of Presentation
  六本木
- Data Source
  KAKENHI-PROJECT-23390256
[Presentation] Ectopic expression of Lhx2 in muscle satellite cells inhibits their myotube differentiation2011
- Author(s)
  Kodaka Y, Kitajima K, Matsuda R, Hara T
- Organizer
  The 34th Annual Meeting of the Molecular biology Society of Japan
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-21591204
[Presentation] The role of Foxo1 in the development of hematopoietic cells2010
- Author(s)
  Minehata K, Kitajima K, Hara T
- Organizer
  DECODE Winter Workshop 2010
- Place of Presentation
  Yuzawa
- Data Source
  KAKENHI-PROJECT-21591204
[Presentation] Long-term repopulation of adult hematopoiesis by in vitro differentiated blood cells from ESCs/iPSCs by LIM homeobox transcription factor, Lhx22010
- Author(s)
  Kitajima K, Zheng J, Minehata K, Nakano T, Hara T
- Organizer
  The 8th Stem Cell Research Symposium
- Place of Presentation
  Awaji
- Data Source
  KAKENHI-PROJECT-21591204
[Presentation] Induction of in vivo hematopoiesis-repopulating cells from mouse pluripotent stem cells by LIM-homeobox transcription factor, 1hx22010
- Author(s)
  Kenji Kitajima
- Organizer
  DECODE Winter Workshop 2010
- Place of Presentation
  新潟県、湯沢市、Yuzawa Hot Spring
- Data Source
  KAKENHI-PROJECT-21591204
[Presentation] Induction and expansion of pluripotent stem cells-derived engraftable hematopoietic progenitor cells by LIM-homeodomain transcription factor lhx22010
- Author(s)
  Kitajima K, Hara T
- Organizer
  5th International Symposium on GATA factors
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-21591204
[Presentation] Induction of in vivo hematopoiesis-repopulating cells from mouse pluripotent stem cells by LIM-homeobox transcription factor, lhx22010
- Author(s)
  Kenji Kitajima
- Organizer
  DECODE Winter Workshop 2010
- Place of Presentation
  新潟県、湯沢市、Yuzawa Hot Spring
- Data Source
  KAKENHI-PROJECT-20052016
[Presentation] Induction of in vivo hematopoiesis-repopulating cells from mouse pluripotent stem cells by LIM-homeobox transcription factor, lhx22010
- Author(s)
  Kitajima K, Zheng J, Minehata K, Nakano T, Hara T
- Organizer
  DECODE Winter Workshop 2010
- Place of Presentation
  Yuzawa
- Data Source
  KAKENHI-PROJECT-21591204
[Presentation] Long-term repopulation of adult hematopoiesis by in vitro differentiated blood cells from ESCs/iPSCs by LIM homeobox transcription factor, Lhx2-2010
- Author(s)
  Kitajima K
- Organizer
  The 8^<th> Stem Cell Research Symposium
- Place of Presentation
  Awaji
- Data Source
  KAKENHI-PROJECT-21591204
[Presentation] Induction and expansion of pluripotent stem cells-derived engraftable hematopoietic progenitor cells by LIM-homeodomain transcription factor lhx22010
- Author(s)
  Kitajima K
- Organizer
  5^<th> International Symposium on GATA factors
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-21591204
[Presentation] The role of Foxo1 in the development of hematopoietic cells2009
- Author(s)
  Minehata K, Kitajima K, Hara T
- Organizer
  The 32nd Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-21591204
[Presentation] Establishment and effects of epigenetic pattern regulated by a tissue specific transcription factor2009
- Author(s)
  Kenji Kitajima
- Organizer
  The 7th Stem Cell Research Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-20052016
[Presentation] Establishment and effects of epigenetic pattern regulated by a tissue specific transcription factor2009
- Author(s)
  Kitajima K, Zheng J, Nakano T
- Organizer
  The 7th Stem Cell Research Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-21591204
[Presentation] 転写因子依存的なエピジェネティック修飾を介した細胞運命決定2008
- Author(s)
  北島健二ら
- Organizer
  第6回幹細胞シンポジウム
- Place of Presentation
  学術総合センター(東京)
- Data Source
  KAKENHI-PROJECT-20052016
[Presentation] 転写因子依存的なエピジェネティック修飾を介した細胞運命決定2008
- Author(s)
  北島健二, 鄭潔, 杉山大二朗, 顔宏哲, 仲野徹
- Organizer
  第6回幹細胞シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591111
[Presentation] GATA-1欠損赤血球系細胞の自己複製能・分化多能性獲得2007
- Author(s)
  北島健二
- Organizer
  第3回血液学若手の会
- Place of Presentation
  東京
- Year and Date
  2007-07-21
- Data Source
  KAKENHI-PROJECT-19591111
[Presentation] 転写因子PU.1による造血細胞の多能性・自己複製制御2007
- Author(s)
  北島健二, 鄭潔, 顔宏哲, 杉山大二朗, 仲野徹
- Organizer
  第5回幹細胞シンポジウム
- Place of Presentation
  淡路
- Data Source
  KAKENHI-PROJECT-19591111
[Presentation] 転写因子PU.1による造血細胞の多能性・自己複製制御2007
- Author(s)
  北島健二
- Organizer
  第5回幹細胞シンポジウム
- Place of Presentation
  兵庫県立淡路夢舞台国際会議場
- Data Source
  KAKENHI-PROJECT-19591111
[Presentation] GSK-3阻害による効率的なES細胞の樹立2007
- Author(s)
  楳原宏紀, 木村透, 大塚哲, 中村肇伸, 北島健二, 伊川正人, 岡部勝, 丹羽仁史, 仲野徹
- Organizer
  第5回幹細胞シンポジウム
- Place of Presentation
  淡路
- Data Source
  KAKENHI-PROJECT-19591111
[Presentation] 転写因子PU.1による造血細胞の多能性・自己複製制御2007
- Author(s)
  北島健二
- Organizer
  第5回幹細胞シンポジウム
- Place of Presentation
  兵庫県立淡路夢舞台国際会議場
- Data Source
  KAKENHI-PROJECT-18055020
[Presentation] Transcription factor Lhx2 inhibits proliferation of T-cell acute lymphoblastic leukemia-derived cells.
- Author(s)
  Miyashita K, Kitajima K, Hara T.
- Organizer
  The 12th Stem Cell Research Symposium
- Place of Presentation
  九州大学・百年講堂　（福岡県・福岡市）
- Year and Date
  2014-05-30 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-24591415

1. NAKANO Toru (00172370)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TARUTANI Masahito (30301261)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. HARA Takahiko (80280949)

# of Collaborated Projects: 2 results

# of Collaborated Products: 33 results
4. KIMURA Tohru (50280962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Takahashi yuna

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 田中貴代子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

kitajima kenji 北島 健二

KITAJIMA Kenji 北島 健二

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Induction of hematopoietic stem cells from mouse embryonic stem cells by inflammatory cytokinesPrincipal Investigator

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Investigation of developmental regulators for human hematopoietic stem cells and downstream road-blocker(s) of Lhx2

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Development of novel differentiation induction system of hematopoietic stem cells from human induced pluripotent stem cellsPrincipal Investigator

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Characterization and exploration of bone marrow niche regulators for hematopoietic stem cells

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Establishment of epigenetic pattern during cell differentiationPrincipal Investigator

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血液細胞の分化多能性・自己複製能を制御するデコード回路の解明Principal Investigator

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Roles of phosphorylation signals in regulation of stem cell systems

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A study of molecular mechanisms underlying the irreversibility of hematopoieticdifferentiationPrincipal Investigator

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転写因子制御による血液細胞の増幅とその利用Principal Investigator

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Hematopoietic lineage determination by transcription factors.Principal Investigator

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[Journal Article] Nitric Oxide and a Conditioned Medium Affect the Hematopoietic Development in a Microfluidic Mouse Embryonic Stem Cell/OP9 Co-Cultivation System2020

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[Journal Article] In vitro differentiation of mouse T cell-derived hybrid cells obtained through cell fusion with embryonic stem cells2019

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[Journal Article] Inhibitory action of an ERK1/2 inhibitor on primitive endoderm cell differentiation from mouse embryonic stem cells.2019

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kitajima kenji 北島健二

KITAJIMA Kenji 北島健二