Tsuboi Akihiro 坪井昭博

… Alternative Names

坪井昭博ツボイアキヒロ

TSUBOI Akihiro 坪井昭博

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Researcher Number	10372608
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 招へい教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 大学院医学系研究科, 招へい教授 2019 – 2021: 大阪大学, 医学系研究科, 寄附講座教授 2016: 大阪大学, 医学系研究科, 寄附講座教授 2014 – 2015: 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 2012 – 2015: 大阪大学, 医学(系)研究科(研究院), 教授 … More 2013: 大阪大学, 医学系研究科, 寄附講座准教授 2011: 大阪大学, 医学(系)研究科(研究院), 寄附金講座教授 2011: 大阪大学, 医学系研究科, 寄附講座教授 2008 – 2010: 大阪大学, 医学系研究科, 寄附講座准教授 2008: 大阪大学, 医学系研究科・寄附講座, 准教授 2007: 大阪大学, 医学系研究科, 寄付講座准教授 Less
Review Section/Research Field	Principal Investigator Neurosurgery / Cerebral neurosurgery Except Principal Investigator Cerebral neurosurgery / Neurosurgery / Basic Section 56010:Neurosurgery-related
Keywords	Principal Investigator テモゾロミド / ヘルパーペプチド / ペプチドワクチン / 悪性神経膠腫 / 脳腫瘍 / 腫瘍免疫 / 膠芽腫 / ＷＴ１ / 臨床試験 / 化学療法併用 … More / 悪性神経膠種 / 腫瘍免疫療法 / 癌免疫療法 / WT1 / がんワクチン … More Except Principal Investigator WT1 / 悪性神経膠腫 / 膠芽腫 / ペプチドワクチン / 免疫療法 / 悪性グリオーマ / 腫瘍血管正常化 / 腫瘍幹細胞 / heterogeneity / 免疫応答 / 腫瘍形成能 / 腫瘍血管新生能 / tumor invasion / angiogenesis / tumor formation / glioma stem cell / ALCAM/sALCAM / HLA class1 / 腫瘍浸潤リンパ球 / 免疫逃避 / がん免疫療法 / 神経膠腫 / TSPO-PET / メチオニン-PET / IDO / MDSC / グリオーマ / PD-L1 / PD-1 / HLA class 1 / GBM / glioma / immunotherapy / peptide vaccine / 脳腫瘍学 / 予後因子 / 治療反応性 / がんワクチン療法 / ヘルパーT細胞 Less

Relationship between immune response in therapies for malignant glioma and tymor heterogeneity
- Principal Investigator
  
  Naoki Kagawa
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka University
Enhancement of effects of WT1 peptide-based immunotherapy for malignant glioma.Principal Investigator
- Principal Investigator
  
  Tsuboi Akihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Osaka University
Functional role and contribution to angiogenesis of WT1 /ALCAM molecules in glioma stem cell
- Principal Investigator
  
  Hashimoto Naoya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Kyoto Prefectural University of Medicine
  Osaka University
Overcoming immune escape in WT1 peptide vaccination for malignant glioma
- Principal Investigator
  
  Chiba Yasuyoshi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Research Institute, Osaka Medical Center for Maternal and Child Health
  Osaka University
Predictive/prognostic factors and escape phenomenon on WT1 peptide vaccination against malignant gliomas
- Principal Investigator
  
  HASHIMOTO Naoya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Osaka University
Enhancement of effects of WT1 peptide-based immunotherapy for malignant gliomaPrincipal Investigator
- Principal Investigator
  
  TSUBOI Akihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Osaka University
Investigation of the immunotherapy targeting WT1 combined with chemotherapy against newly diagnosed malignant glioma.
- Principal Investigator
  
  IZUMOTO Shuichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Hyogo College of Medicine
Induction and characterization of WT1-specific Th1-type CD4(+) T cells to develop WT1 immunotherapy against malignant gliomas.
- Principal Investigator
  
  IZUMOTO Shuichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Hyogo College of Medicine
  Osaka University

All 2023 2021 2020 2019 2016 2015 2014 2013 2012 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT12023
- Author(s)
  Oji Y, Kagawa N, Arita H, Naka N, Hamada KI, Outani H, Shintani Y, Takeda Y, Morii E, Shimazu K, Suzuki M, Nishida S, Nakata J, Tsuboi A, Iwai M, Hayashi S, Imanishi R, Ikejima S, Kanegae M, Iwamoto M, Ikeda M, Yagi K, Shimokado H, Nakajima H, Hasegawa K, Morimoto S, Fujiki F　他
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 2 Pages: 393-393
- DOI
  10.3390/cancers15020393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07251, KAKENHI-PROJECT-19K08650, KAKENHI-PROJECT-20K08732, KAKENHI-PROJECT-22K09283, KAKENHI-PROJECT-23K06761, KAKENHI-PROJECT-19K09457
[Journal Article] Maintenance of WT1 expression in tumor cells is associated with a good prognosis in malignant glioma patients treated with WT1 peptide vaccine immunotherapy2021
- Author(s)
  Yokota Chisato、Kagawa Naoki、Takano Koji、Chiba Yasuyoshi、Kinoshita Manabu、Kijima Noriyuki、Oji Yusuke、Oka Yoshihiro、Sugiyama Haruo、Tsuboi Akihiro、Izumoto Shuichi、Kishima Haruhiko、Hashimoto Naoya
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 71 Issue: 1 Pages: 189-201
- DOI
  10.1007/s00262-021-02954-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18390, KAKENHI-PROJECT-19K08345, KAKENHI-PROJECT-19K09457, KAKENHI-PROJECT-19K09526, KAKENHI-PROJECT-19K18426, KAKENHI-PROJECT-22K09283
[Journal Article] Distinct difference in tumor-infiltrating immune cells between Wilms’ tumor gene 1 peptide vaccine and anti-programmed cell death-1 antibody therapies2021
- Author(s)
  Yokota Chisato、Nakata Jun、Takano Koji、Nakajima Hiroko、Hayashibara Hiromu、Minagawa Hikaru、Chiba Yasuyoshi、Hirayama Ryuichi、Kijima Noriyuki、Kinoshita Manabu、Hashii Yoshiko、Tsuboi Akihiro、Oka Yoshihiro、Oji Yusuke、Kumanogoh Atsushi、Sugiyama Haruo、Kagawa Naoki、Kishima Haruhiko
- Journal Title
  
  Neuro-Oncology Advances
  
  Volume: 3 Issue: 1 Pages: 1-10
- DOI
  10.1093/noajnl/vdab091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18390, KAKENHI-PROJECT-19K08345, KAKENHI-PROJECT-19K09457, KAKENHI-PROJECT-19K18426
[Journal Article] Encouraging Clinical Evolution of a Pediatric Patient With Relapsed Diffuse Midline Glioma Who Underwent WT1-Targeting Immunotherapy: A Case Report and Literature Review2020
- Author(s)
  Hashii Yoshiko、Oka Yoshihiro、Kagawa Naoki、Hashimoto Naoya、Saitou Hiroyuki、Fukuya Syogo、Kanegae Mizuki、Ikejima Sayaka、Oji Yusuke、Ozono Keiichi、Tsuboi Akihiro、Sugiyama Haruo
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 10 Pages: 1188-1188
- DOI
  10.3389/fonc.2020.01188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09457
[Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide.2016
- Author(s)
  Oji Y, Hashimoto N, Tsuboi A, Murakami Y, Iwai M, Kagawa N, Chiba Y, Izumoto S, Elisseeva O, Ichinohasama R, Sakamoto J, Morita S, Nakajima H, Takashima S, Nakae Y, Nakata J, Kawakami M, Nishida S, Hosen N, Fujiki F, Morimoto S, Adachi M, Iwamoto M, Oka Y, Yoshimine T, Sugiyama H.
- Journal Title
  
  Int J Cancer.
  
  Volume: 139 Issue: 6 Pages: 1391-401
- DOI
  10.1002/ijc.30182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462257, KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-26462195, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-15K08609, KAKENHI-PROJECT-15K09173, KAKENHI-PROJECT-15K09476, KAKENHI-PROJECT-15K10331, KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-15K19550
[Journal Article] Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response2015
- Author(s)
  Naoya Hashimoto, Akihiro Tsuboi, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Norio Arita, Toshiki Yoshimine, Haruo Sugiyama
- Journal Title
  
  Cancer Immunology Immunotherapy
  
  Volume: - Issue: 6 Pages: 707-16
- DOI
  10.1007/s00262-015-1674-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25830116, KAKENHI-PROJECT-26462180, KAKENHI-PROJECT-26462195, KAKENHI-PROJECT-15K10331, KAKENHI-PROJECT-24592160, KAKENHI-PROJECT-25462256
[Journal Article] Functional human Th17 clones with WT1-specific helper activity.2013
- Author(s)
  Tachino S, Fujiki F, Oka Y, Tsuboi A, Morimoto S, Lin YH, Tamanaka T, Kondo K, Nakajima H, Nishida S, Hosen N, Oji Y, Kumanogoh A, Sugiyama H.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 62（4） Issue: 4 Pages: 801-10
- DOI
  10.1007/s00262-012-1385-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592123, KAKENHI-PROJECT-24591164, KAKENHI-PROJECT-24700991, KAKENHI-PROJECT-25462257, KAKENHI-PROJECT-25830116
[Journal Article] HLA-DPB1*05: 01-restricted WT1332-specific TCR-transduced CD4+ T lymphocytes display a helper activity for WT1-specific CTL induction and a cytotoxicity against leukemia cells.2013
- Author(s)
  Lin Y, Fujiki F, Katsuhara A, Oka Y, Tsuboi A, Aoyama N, Tanii S, Nakajima H, Tatsumi N, Morimoto S, Tamanaka T, Tachino S, Hosen N, Nishida S, Oji Y, Kumanogoh A, Sugiyama H.
- Journal Title
  
  J Immunother.
  
  Volume: 36（3） Issue: 3 Pages: 159-70
- DOI
  10.1097/cji.0b013e3182873581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592123, KAKENHI-PROJECT-23790622, KAKENHI-PROJECT-24591164, KAKENHI-PROJECT-24700991, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-25462257
[Journal Article] Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma2012
- Author(s)
  Chiba Y, Kinoshita M, Okita Y, Tsuboi A, Isohashi K, Kagawa N, Fujimoto Y, Oji Y, Oka Y, Shimosegawa E, Morita S, Hatazawa J, Sugiyama H, Hashimoto N, Yoshimine T
- Journal Title
  
  J Neurosurg
  
  Volume: 116(4) Pages: 835-842
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592123
[Journal Article] Biased usage of T cell receptorβ-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8(+) T cells in patients with solid tumors and healthy donors2012
- Author(s)
  Morimoto S, Oka Y, Tsuboi A, Tanaka Y, Fujiki F, Nakajima H, Hosen N, Nishida S, Nakata J, Nakae Y, Maruno M, Myoui A, Enomoto T, Izumoto S, Sekimoto M, Kagawa N, Hashimoto N, Yoshimine T, Oji Y, Kumanogoh A, Sugiyama H
- Journal Title
  
  Cancer Sci
  
  Volume: 103(3) Pages: 408-414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592123
[Journal Article] WT1 peptide vaccine induces reduction in minimal residual disease in an Imatinib-treated CML patient.2010
- Author(s)
  Oji Y, Tsuboi A, Sugiyama H
- Journal Title
  
  Eur J Haematol 85
  
  Pages: 358-360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] Effects of concomitant temozolomide and radiation therapies on WT1-specific T-cells in malignant glioma.2010
- Author(s)
  Chiba Y, Hashimoto N, Tsuboi A
- Journal Title
  
  Jpn J Clin Oncol 40
  
  Pages: 395-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] Biased usage of BV gene families of T-cell receptors of WT1 (Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies.2010
- Author(s)
  Tanaka-Harada Y, Tsuboi A, Sugiyama H
- Journal Title
  
  Cancer Sci 101
  
  Pages: 594-600
- NAID
  10026589035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] Effects of concomitant temozolomide and radiation therapies on WT1-specific T cells in malignant glioma.2010
- Author(s)
  Chiba Y, Hashimoto N, Tsuboi A., et al.
- Journal Title
  
  JPN J Clin Oncol
  
  Volume: 5 Pages: 395-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591609
[Journal Article] Prognostic value of WT1 protein expression level and MIB-1 staining index as predictor of response to WT1 immunotherapy in glioblastoma patients.2010
- Author(s)
  Chiba Y, Hashimoto N, Tsuboi A
- Journal Title
  
  Brain Tumor Pathol 27
  
  Pages: 29-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] High frequencies of less differentiated and more proliferative WT1-specific CD8+ T cells in bone marrow in tumor-bearing patients : an important role of bone marrow as a secondary lymphoid organ.2010
- Author(s)
  Murao A, Oka Y, Tsuboi A
- Journal Title
  
  Cancer Sci 101
  
  Pages: 848-854
- NAID
  10026590478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] Prognostic value of WT1 protein expression level and MIB-1 staining index as predistor of response to WT1 immunotherapy in glioblastoma patients.2010
- Author(s)
  Chiba Y, Hashimoto N, Tsuboi A., et al.
- Journal Title
  
  Brain Tumor Pathol
  
  Volume: 1 Pages: 29-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591609
[Journal Article] Sensitive immunohistochemical detection of WT1 protein in tumors with anti-WT1 antibody against WT1 235 peptide.2010
- Author(s)
  Ichinohasama R, Tsuboi A, Sugiyama H
- Journal Title
  
  Cancer Sci 10
  
  Pages: 1089-1092
- NAID
  10026591723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] A clear correlation between WT1-specific Th response and clinical response in WT1 CTL epitope vaccination.2010
- Author(s)
  Fujiki F, Tsuboi A, Izumoto S
- Journal Title
  
  Anticancer Res 30
  
  Pages: 2247-2254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] WT1遺伝子産物を標的とする免疫療法2010
- Author(s)
  橋本直哉、坪井昭博、千葉泰良, ら
- Journal Title
  
  日本臨床68(10)増刊号
  
  Volume: 10 Pages: 515-519
- Data Source
  KAKENHI-PROJECT-22591609
[Journal Article] Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle.2009
- Author(s)
  Nakamura J, Tsuboi A, Sugiyama H
- Journal Title
  
  Int J Oncol 34
  
  Pages: 1181-1189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] WT1 peptide vaccination for the treatment of hematological malignancies : the present status and future direction.2009
- Author(s)
  Oka Y, Tsuboi A, Sugiyama H
- Journal Title
  
  Rinsho Ketsueki 50
  
  Pages: 352-7
- NAID
  10024959811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] WT1 IgG antibody for early detection of nonsmall cell lung cancer and as its prognostic factor.2009
- Author(s)
  Oji Y, Tsuboi A, Sugiyama H
- Journal Title
  
  Int J Cancer 125
  
  Pages: 381-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] Wilms' tumor 1 (WT1) peptide immunotherapy for gynecological malignancy.2009
- Author(s)
  Ohno S, Tsuboi A, Sugiyama H
- Journal Title
  
  Anticancer Res 29
  
  Pages: 4779-4784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] WT1 peptide vaccine as a paradigm for "cancer antigen-derived peptide"-based immunotherapy for malignancies : successful induction of anti-cancer effect by vaccination with a single kind of WT1 peptide.2009
- Author(s)
  Oka Y, Tsuboi A, Sugiyama H
- Journal Title
  
  Anticancer Agents Med Chem
  
  Pages: 787-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] WT1遺伝子産物を標的とする脳腫瘍の免疫療法:特集:脳腫瘍研究の最前線-遺伝子解析から治療までー2009
- Author(s)
  橋本直哉、坪井昭博、泉本修一
- Journal Title
  
  脳と神経 61
  
  Pages: 805-814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] WT1 (Wilms tumor 1) peptide immunotherapy for childhood rhabdomyosarcoma : a case report.2009
- Author(s)
  Ohta H, Tsuboi A, Murao A
- Journal Title
  
  Pediatr Hematol Oncol 26
  
  Pages: 74-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] Wilms' tumor gene WT1-shRNA as a potent apoptosis-inducing agent for solid tumors.2008
- Author(s)
  Tatsumi N, Oji Y, Tsuboi A
- Journal Title
  
  Int J Oncol 32
  
  Pages: 701-711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme.2008
- Author(s)
  Izumoto S, Tsuboi A, Oka Y
- Journal Title
  
  J Neurosurg. 108
  
  Pages: 963-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] Cancer antigen WT1 protein-derived peptide-based treatment of cancer-toward the further development.2008
- Author(s)
  Oka Y, Tsuboi A, Fujiki F
- Journal Title
  
  Curr Med Chem 15
  
  Pages: 3052-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] A WT1 protein-derived, naturally processed 16-mer peptide, WT1(332), is a promiscuous helper peptide for induction of WT1-specific Th1-type CD4(+) T cells.2008
- Author(s)
  Fujiki F, Oka Y, Kawakatsu M, Tsuboi A
- Journal Title
  
  Microbiol Immunol 52
  
  Pages: 591-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] WT1 peptide vaccine for the treatment of cancer.2008
- Author(s)
  Oka Y, Tsuboi A
- Journal Title
  
  Curr Opin Immunol 20
  
  Pages: 211-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] Identification of a WT1 protein-derived peptide, WT1, as a HLA-A 0206-restricted, WT1-specific CTL epitope.2008
- Author(s)
  Li Z, Oka Y, Tsuboi A
- Journal Title
  
  Microbiol Immunol 52
  
  Pages: 551-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390384
[Journal Article] Wilms tumor gene WT1 peptide-based immunotherapy induced a minimal response in a patient with advanced therapy-resistant multiple myeloma.2007
- Author(s)
  Tsuboi A
- Journal Title
  
  Int J Hematol 86
  
  Pages: 414-417
- NAID
  10019533221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659366
[Presentation] 再発悪性神経膠腫に対するWT1カクテルワクチン療法（WT1 trio）2020
- Author(s)
  香川尚己、尾路祐介、坪井昭博、平山龍一、木嶋教行、木下学、岡芳弘、杉山治夫、貴島晴彦
- Organizer
  第38回日本脳腫瘍病理学会
- Data Source
  KAKENHI-PROJECT-19K09457
[Presentation] 再発神経膠腫に対する3種混合WT1ペプチドワクチン療法（WT1 trio）の安全性と有効性2019
- Author(s)
  香川尚己、尾路祐介、坪井昭博、平山龍一、木嶋教行、木下学、岡芳弘、杉山治夫、貴島晴彦
- Organizer
  第37回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09457
[Presentation] WT1 peptide vaccination for glioblastomas; survivals, biomarkers, and response assessment2016
- Author(s)
  Naoya Hashimoto, Akihito Tsuboi,Toshiki Yoshimine, Haruo Sugiyama
- Organizer
  ICBTRT 2016
- Place of Presentation
  沖縄
- Year and Date
  2016-04-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462180
[Presentation] 神経膠腫に対するWT1ペプチドワクチン療法の新展開2015
- Author(s)
  橋本直哉,　坪井昭博,　香川尚己, 千葉泰良,　木下　学,　木嶋教行, 有田英之, 平山龍一, 永野大輔, 高野浩二, 福屋章悟, 福永貴典, 岡　芳弘, 尾路祐介, 杉山治夫,吉峰俊樹
- Organizer
  第74回日本脳神経外科学会総会
- Place of Presentation
  札幌
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-26462180
[Presentation] 悪性神経膠腫を対象としたWT１キラーペプチドとＷＴ１ヘルパーペプチドを併用したペプチド免疫療法2015
- Author(s)
  坪井昭博、橋本　直哉、香川尚己、西田　純幸,森本　創世子、藤木　文博、中島　博子、吉峰俊樹、岡　芳弘、杉山治夫
- Organizer
  第18回WT1ペプチド癌免疫療法研究
- Place of Presentation
  大阪大学医学部（大阪府吹田市）
- Year and Date
  2015-03-31
- Data Source
  KAKENHI-PROJECT-26462180
[Presentation] WT1 peptide IgG antibody as a predictive marker of WT1 peptide vaccine immunotherapy2015
- Author(s)
  Yusuke Oji, Naoya Hashimoto, Akihiro Tsuboi, Yui Murakami, Miki Iwai, Naoki Kagawa, Yasuyoshi Chiba et.al.
- Organizer
  The 8th International Conference on WT1 in Human Neoplasia
- Place of Presentation
  KBS Kyoto Hall, Kyoto, Japan
- Year and Date
  2015-11-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462257
[Presentation] 神経膠腫に対するWT1ペプチドワクチン療法の新展開2015
- Author(s)
  橋本直哉, 坪井昭博, 香川尚己, 千葉泰良, 木嶋教行, 木下学, 有田英之, 平山龍一, 永野大輔, 高野浩司, 福屋章悟, 福永貴典, 岡芳弘, 尾路祐介, 杉山治夫, 吉峰俊樹
- Organizer
  第74回日本脳神経外科学会学術総会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-25462257
[Presentation] 悪性神経膠腫に対するテモゾロミド併用のWT１ペプチド免疫療法とimmuno RANO2015
- Author(s)
  橋本直哉、坪井昭博、香川尚己、有田英之、尾路祐介、岡芳弘、吉峰俊樹、杉山治夫
- Organizer
  第18回WT1ペプチド癌免疫療法研究
- Place of Presentation
  大阪大学医学部（大阪府吹田市）
- Year and Date
  2015-03-31
- Data Source
  KAKENHI-PROJECT-26462180
[Presentation] New challenge of WT1 peptide vaccination for malignant glioma2015
- Author(s)
  Akihiro Tsuboi, Naoya Hashimoto, Naoki Kagawa, Yasuyoshi Chiba, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Shuichi Izumoto, Norio Arita, Soyoko Morimoto, Fumihiro Fujiki, Hiroko Nakajima, Naoki Hosen, Yusuke Oji, Sumiyuki Nishida, Satoshi Morita, Junichi Sakamoto, Toshiki Yoshimine, Haruo Sugiyama
- Organizer
  The 8th International Conference on WT1 in Human Neoplasia
- Place of Presentation
  KBS Kyoto Hall, Kyoto, Japan
- Year and Date
  2015-11-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462257
[Presentation] WT1ペプチドワクチンの治療反応性予測マーカー：WT1ペプチド抗体2015
- Author(s)
  尾路祐介、橋本直哉、坪井昭博、村上由依、岩井美樹、岡芳弘、杉山治夫
- Organizer
  第18回WT1ペプチド癌免疫療法研究
- Place of Presentation
  大阪大学医学部（大阪府吹田市）
- Year and Date
  2015-03-31
- Data Source
  KAKENHI-PROJECT-26462180
[Presentation] グリオーマのWT1ペプチドワクチン療法；テモゾロミド併用の効果、バイオマーカーと免疫学的応答2014
- Author(s)
  橋本直哉、香川尚己、千葉泰良、坪井昭博、木下学、岡芳弘、尾路祐介、泉本修一、有田憲生、杉山治夫、吉峰俊樹
- Organizer
  日本脳神経外科学会第73回学術総会
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Year and Date
  2014-10-09
- Data Source
  KAKENHI-PROJECT-26462180
[Presentation] 悪性グリオーマに対するWT1 CTL ペプチドとWT1 ヘルパーペプチドを併用した免疫療法2014
- Author(s)
  橋本直哉, 坪井昭博, 香川尚己, 福屋章悟, 永野大輔, 高野浩司, 平山龍一, 有田英之, 千葉泰良, 木下学, 森本創世子, 岡芳弘, 尾路祐介, 杉山治夫, 吉峰俊樹.
- Organizer
  第32回日本脳腫瘍学会学術集会
- Place of Presentation
  シェラトン・グランデ・トーキョーベイ・ホテル（千葉県浦安市）
- Year and Date
  2014-11-30
- Data Source
  KAKENHI-PROJECT-26462180
[Presentation] RESPONSEASSESSMENTS IN WT1 PEPTIDE VACCINATION AND LONG TERM RESULTS OF COMOZOLOMIDE THERAPY2014
- Author(s)
  Naoya Hashimoto,Akihiro Tsuboi,Yasuyoshi Chiba,Yoshihiro Oka,Soyoko Morimoto,Hiroko Nakajima,Sumiyuki Nishida,Naoki Hosen,Naoki Kagawa,Yusuke Oji,Toshiki Yoshimine,Haruo Sugiyama
- Organizer
  The7th International Conference on WT1 in human neoplasia
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-04-23
- Data Source
  KAKENHI-PROJECT-26462180
[Presentation] WT1 ペプチドワクチンを用いた小児固形がんに対する免疫療法2012
- Author(s)
  橋井佳子、坪井昭博、西田純幸、尾路祐介、岡芳弘、杉山治夫
- Organizer
  第16回日本がん免疫学会総会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2012-07-28
- Data Source
  KAKENHI-PROJECT-22591609
[Presentation] 初発悪性神経膠腫を対象としたテモゾロミド併用ＷＴ１ペプチドワクチン療法2012
- Author(s)
  坪井　昭博、橋本　直哉
- Organizer
  第７１回日本癌学会
- Place of Presentation
  札幌ホテルロイトン札幌
- Data Source
  KAKENHI-PROJECT-22591609
[Presentation] WT1 ペプチドワクチン効果増強を求めて-マウスモデルを基にした検討2012
- Author(s)
  中島博子、岡芳弘、坪井昭博、杉山治夫
- Organizer
  16回日本がん免疫学会総会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2012-07-26
- Data Source
  KAKENHI-PROJECT-22591609
[Presentation] 初発悪性神膠種を対象としたテミゾロミド併用WT1 ペプチドワクチン第I相臨床試験2012
- Author(s)
  坪井昭博、橋本直哉、岡芳弘、香川尚己、木下学、木嶋教行、千葉泰良、尾路祐介、保仙直毅、西田純幸、吉峰俊樹、杉山治夫
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-22591609
[Presentation] 初発悪性神経膠腫を対象としたテモゾロミド併用ＷＴ１ペプチドワクチン第Ｉ相臨床試験2012
- Author(s)
  坪井　昭博、橋本　直哉
- Organizer
  第16回日本がん免疫療法学会
- Place of Presentation
  北海道大学学術交流会館
- Data Source
  KAKENHI-PROJECT-22591609
[Presentation] 初発悪性神経膠腫を対象としたテモゾロミド併用WT1 ペプチドワクチン第I相臨床試験2012
- Author(s)
  坪井昭博、橋本直哉、香川尚己、千葉泰良、岡芳弘、尾路祐介、保仙直毅、西田純幸、吉峰俊樹、杉山治夫
- Organizer
  第16回日本がん免疫学会総会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2012-07-26
- Data Source
  KAKENHI-PROJECT-22591609
[Presentation] 腫瘍特異的免疫療法の進展2012
- Author(s)
  坪井　昭博、橋本　直哉
- Organizer
  第16回日本統合医療学会
- Place of Presentation
  大阪大学　コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22591609
[Presentation] WT1 Immunotherapy for Malignant Gliomas ; DTH and Methionine PET as Strong Prognostic Indicators2010
- Author(s)
  Hashimoto N, Tsuboi A., et al.
- Organizer
  7th Meeting of Asian Society for Neuro-Oncology
- Place of Presentation
  Seoul, Korea
- Year and Date
  2010-06-12
- Data Source
  KAKENHI-PROJECT-22591609
[Presentation] 膠芽種に対するWT1ペプチドワクチン療法における長期生存例と予後予測因子2010
- Author(s)
  橋本直哉、坪井昭博、千葉泰良, ら
- Organizer
  第23回日本バイオセラピィ学会学術集会総会
- Place of Presentation
  大阪市
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22591609
[Presentation] 膠芽種に対するWT1ペプチドワクチン療法における長期生存例と予後予測因子2010
- Author(s)
  橋本直哉、千葉泰良、坪井昭博, ら
- Organizer
  第28回日本脳腫瘍学会
- Place of Presentation
  軽井沢市
- Year and Date
  2010-11-28
- Data Source
  KAKENHI-PROJECT-22591609
[Presentation] WT1ペプチドを用いた悪性脳腫瘍の治療2010
- Author(s)
  橋本直哉、千葉泰良、吉峰俊樹、坪井昭博, ら
- Organizer
  第48回日本癌治療学会学術集会
- Place of Presentation
  京都市
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-22591609
[Presentation] 膠芽腫に対するWT1ペプチドワクチン療法の新たな知見:長期生存例、予後予測因子と新規臨床試験2010
- Author(s)
  橋本直哉、千葉泰良、坪井昭博, ら
- Organizer
  第69回日本脳神経外科学会総会
- Place of Presentation
  福岡市
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-22591609
[Presentation] 再発悪性グリオーマに対するWT1ペプチドワクチン療法後の腫瘍浸潤リンパ球と免疫逃避
- Author(s)
  千葉泰良、橋本直哉、坪井昭博、岡芳弘、香川尚己、尾路祐介、吉峰俊樹、杉山治夫
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-25462257
[Presentation] Immune escape in human malignant gliomas after WT1 peptide vaccination
- Author(s)
  Yasuyoshi Chiba, Naoya Hashimoto, Naoki Kagawa, Ryuuichi Hirayama, Akihiro Tsuboi, Yuusuke Oji, Yoshihiro Oka, Haruo Sugiyama, Toshiki Yoshimine
- Organizer
  SNO 4th Quadrennial Meeting of the World Federation of Neuro-Oncology
- Place of Presentation
  San Francisco（ＵＳＡ）
- Data Source
  KAKENHI-PROJECT-25462257
[Presentation] A direct comparison of response assessments in a phase II clinical trial of WT1 peptide vaccination; Macdonald, RECIST and RANO criteria
- Author(s)
  Naoya Hashimoto, Yasuyoshi Chiba, Akihiro Tsuboi, Manabu Kinoshita, Ryuichi Hirayama, Naoki Kagawa, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama, Toshiki Yoshimine
- Organizer
  SNO 4th Quadrennial Meeting of the World Federation of Neuro-Oncology
- Place of Presentation
  San Francisco（ＵＳＡ）
- Data Source
  KAKENHI-PROJECT-25462257
[Presentation] WT1ペプチドワクチン療法におけるMRIを用いた画像評価法の検討
- Author(s)
  千葉泰良、橋本直哉、坪井昭博、香川尚己、平山龍一、尾路祐介、岡芳弘、杉山治夫、吉峰俊樹
- Organizer
  第31回日本脳腫瘍学会学術集会
- Place of Presentation
  フェニックスシーガイアリゾート（宮崎）
- Data Source
  KAKENHI-PROJECT-25462257
[Presentation] 再発悪性グリオーマに対するWT1ペプチドワクチン療法後の免疫逃避機構
- Author(s)
  千葉泰良、橋本直哉、坪井昭博、香川尚己、平山龍一、尾路祐介、岡芳弘、杉山治夫、吉峰俊樹
- Organizer
  第72回日本脳神経外科学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-25462257
[Presentation] 初発膠芽腫に対するテモゾロミド併用WT1ペプチドワクチン療法　第1相臨床試験
- Author(s)
  坪井昭博
- Organizer
  日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-23592123
[Presentation] グリオーマのWT1ペプチドワクチン療法；バイオマーカーの探索と免疫的応答
- Author(s)
  橋本直哉、坪井昭博、千葉泰良、森本創世子、木下学、香川尚己、平山龍一、高野浩司、永野大輔、福屋章悟、岡芳弘、尾路祐介、杉山治夫、吉峰俊樹
- Organizer
  第31回日本脳腫瘍学会学術集会
- Place of Presentation
  フェニックスシーガイアリゾート（宮崎）
- Data Source
  KAKENHI-PROJECT-25462257
[Presentation] 初発膠芽腫に対するテモゾロミド併用WT1ペプチドワクチン療法　第1相臨床試験
- Author(s)
  坪井昭博、橋本直哉、香川尚己、千葉泰良、泉本修一、岡芳弘、尾路祐介、保仙直毅、西田純幸、森本創世子、吉峰俊樹、杉山治夫
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-25462257
[Presentation] 初発膠芽腫に対するテモゾロミド併用WT1ペプチドワクチン療法
- Author(s)
  橋本直哉、坪井昭博、千葉泰良、香川尚己、泉本修一、平山龍一、岡芳弘、尾路祐介、吉峰俊樹、杉山治夫
- Organizer
  第17回がん免疫学会総会
- Place of Presentation
  ANAクラウンプラザホテル宇部(山口）
- Data Source
  KAKENHI-PROJECT-25462257
[Presentation] WT1 peptide vaccination for newly diagnosed glioblastomas; phase I clinical trial of combination with temozolomide
- Author(s)
  Naoya Hashimoto,Yasuyoshi Chiba,Noriyuki Kijima,Manabu Kinoshita,Naoki kagawa,Akihiro Tsuboi,Yoshihiro Oka,Yusuke Oji,Haruo Sugiyama,Toshiki Yoshimine
- Organizer
  15th WFNS World Congress of Neurosurgery (WFNS2013)
- Place of Presentation
  Seoul（Korea）
- Data Source
  KAKENHI-PROJECT-25462257
[Presentation] 初発悪性神経膠腫に対するテモゾロミドとWT1ペプチドワクチン併用療法
- Author(s)
  坪井昭博、橋本　直哉、香川　尚己、千葉　泰良、吉峰　俊樹
- Organizer
  第17回WT1ペプチド癌免疫療法研究会
- Place of Presentation
  大阪大学医学部（大阪）
- Data Source
  KAKENHI-PROJECT-25462257

1. HASHIMOTO Naoya (90315945)

# of Collaborated Projects: 7 results

# of Collaborated Products: 40 results
2. IZUMOTO Shuichi (40324769)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. KINOSHITA Manabu (40448064)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. Chiba Yasuyoshi (90533795)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
5. 高野浩司 (90649203)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. KISHIMA Haruhiko (10332743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MORI Kanji (50360269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YUSUKE Tomogane (10412008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Naoki Kagawa (50444542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 藤本康倫 (80589789)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 永野大輔 (70726520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 福屋章悟 (50726502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. NISHIDA Sumiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 横田千里

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 森本創世子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Tsuboi Akihiro 坪井 昭博

坪井 昭博 ツボイ アキヒロ

TSUBOI Akihiro 坪井 昭博

Research Projects

Research Products

Co-Researchers

Relationship between immune response in therapies for malignant glioma and tymor heterogeneity

Principal Investigator

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Review Section

Research Institution

Enhancement of effects of WT1 peptide-based immunotherapy for malignant glioma.Principal Investigator

Principal Investigator

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Research Field

Research Institution

Functional role and contribution to angiogenesis of WT1 /ALCAM molecules in glioma stem cell

Principal Investigator

Project Period (FY)

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Research Institution

Overcoming immune escape in WT1 peptide vaccination for malignant glioma

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Predictive/prognostic factors and escape phenomenon on WT1 peptide vaccination against malignant gliomas

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Enhancement of effects of WT1 peptide-based immunotherapy for malignant gliomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the immunotherapy targeting WT1 combined with chemotherapy against newly diagnosed malignant glioma.

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Induction and characterization of WT1-specific Th1-type CD4(+) T cells to develop WT1 immunotherapy against malignant gliomas.

Principal Investigator

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Research Institution

[Journal Article] WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT12023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Maintenance of WT1 expression in tumor cells is associated with a good prognosis in malignant glioma patients treated with WT1 peptide vaccine immunotherapy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct difference in tumor-infiltrating immune cells between Wilms’ tumor gene 1 peptide vaccine and anti-programmed cell death-1 antibody therapies2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Encouraging Clinical Evolution of a Pediatric Patient With Relapsed Diffuse Midline Glioma Who Underwent WT1-Targeting Immunotherapy: A Case Report and Literature Review2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response2015

Tsuboi Akihiro 坪井昭博

坪井昭博ツボイアキヒロ

TSUBOI Akihiro 坪井昭博