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Kondou Hiroki  近藤 宏樹

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KONDOU Hiroki  近藤 宏樹

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Researcher Number 10373515
Other IDs
Affiliation (Current) 2025: 近畿大学, 奈良病院, 准教授
Affiliation (based on the past Project Information) *help 2016 – 2017: 大阪大学, 医学系研究科, 招へい教員
2015 – 2017: 近畿大学, 医学部附属病院, 講師
2014 – 2015: 大阪大学, 医学(系)研究科(研究院), 招へい教員
2014 – 2015: 大阪大学, 医学(系)研究科(研究院), 研究員
2011 – 2013: 大阪大学, 医学(系)研究科(研究院), 助教 … More
2010: Research Institute, Osaka Medical Center for Maternal and Child Health, 大学院・医学系研究科, 助教
2009 – 2010: Osaka University, 医学系研究科, 助教
2005 – 2008: 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), 環境影響部門, 主任研究員
2007: Research Institute, Osaka Medical Center for Maternal and Child Health, 環境影響部門, 主任研究員
2007: Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka Prefectural Organization, Researcher
2006: Osaka Medical Center and Research Institute for Maternal and Children, Department of Environmental Medicine, Senior Researcher, 環境影響部門, 主任研究員
2005 – 2006: 大阪府立母子保健総合医療センター, 環境影響部門, 主任研究員
2005: Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka Hospital Organization, Senior Researcher, 主任研究員
2004: 大阪府立母子保健総合医療センター研究所, 環境影響部門, 主任研究員 Less
Review Section/Research Field
Principal Investigator
Pediatrics
Except Principal Investigator
Pediatrics / Kidney internal medicine
Keywords
Principal Investigator
胆汁うっ滞 / FGF19 / HNF4α / 肝細胞 / 肝発生 / 器官培養 / 胆汁鬱滞 / KLB / FGFR4 / 胆道閉鎖症 … More / microdisection / SPRY2 / 胆汁酸合成 / CYP7A1 / メタボリックシンドローム / DOHaD / 低出生体重児 / FGF21 / 栄養学 / 肝発生・分化 / アミノ酸トランスポーター / SSH / Hnf4α / 小型肝細胞 / TGF-β / LSKLペプチド / トロンボスポンジン / 肝線維化 … More
Except Principal Investigator
klotho / Na^+ / FGF23 / Grb10 / phosphate / megalin / Pi共輸送担体 / リン酸 / メガリン / 胆道閉鎖症 / Pi co-transporter / megain / FGF-23 / リン酸再吸収 / ナトリウム・リン酸共輸送担体 / 2 / ERK1 / 無機リン酸 / Klotho / Hepatic stellate cell / Hepatocyte damage / Hepatic fibrosis / Tyrosine kinase type receptor / 偽胆管 / 肝硬変 / SH2ドメイン / 肝星細胞 / 肝細胞障害 / 肝線維化 / チロシンキナーゼ型受容体 / vitamin D / receptor associated protein (RAP) / phosphate co-transporter / sodium / reabsorption / endocytosis / ビタミンD / Na / 再吸収 / RAP / エンドサイトーシス / 国際情報交換 / 胆汁うっ滞 / 腸内細菌叢 / 肝機能障害 / プロテオーム解析 / Helicobacter hepaticus / ELISA法 / ペプチド / 血清抗体 / 抗体測定 / イムノブロット / 肝障害 / 小児 / ヘリコバクター・ヘパティカス Less
  • Research Projects

    (10 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (14 People)
  •  Investigation of aberrant regulation of bile acid, glucose, and lipid metabolism under chronic cholestatic state in pediatric liver disease.Principal Investigator

    • Principal Investigator
      KONDOU Hiroki
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kindai University
      Osaka University
  •  The role of intestinal flora in the pathogenesis of biliary atresia

    • Principal Investigator
      Bessho Kazuhiko
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka University
  •  Evaluation of Helicobacter hepaticus infection in children with liver disorders and postoperative biliary atresia

    • Principal Investigator
      Okuda Masumi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Hyogo Medical University
  •  Molecular dynamics of metabolism during perinatal liver developmentPrincipal Investigator

    • Principal Investigator
      KONDOU Hiroki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka University
  •  Hepatocyte nuclear factor 4α promotes protein synthesis through the sodium-coupled neutral amino acid transporter 4 in liver developmentPrincipal Investigator

    • Principal Investigator
      KONDOU Hiroki
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Research Institute, Osaka Medical Center for Maternal and Child Health
  •  肝再生不全新規治療法の開発を目指した肝発生分子基盤の解析Principal Investigator

    • Principal Investigator
      近藤 宏樹
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Research Institute, Osaka Medical Center for Maternal and Child Health
  •  Functional Relationship between the Molecules Involved in the Renal Phosphate Reabsorption

    • Principal Investigator
      MICHIGAMI Toshimi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Research Institute, Osaka Medical Center for Maternal and Child Health
  •  Molecular biological assessment of hepatocyte damage and fibrosis in intractable pediatric liver diseases

    • Principal Investigator
      MUSHIAKE Sotaro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka University
  •  トロンボスポンジン1アンタゴニストを用いた肝線維化分子機構の解析Principal Investigator

    • Principal Investigator
      近藤 宏樹
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Research Institute, Osaka Medical Center for Maternal and Child Health
  •  Molecular Mechanisms Underlying the Reabsorption of Inorganic Phosphate in Renal Tubules

    • Principal Investigator
      MICHIGAMI Toshimi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka Hospital Organization

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005

All Journal Article Presentation

  • [Journal Article] Circulating tricarboxylic acid cycle metabolite levels in citrin-deficient children with metabolic adaptation, with and without sodium pyruvate treatment.2017

    • Author(s)
      Nagasaka H, Komatsu H, Inui A, Nakacho M, Morioka I, Tsukahara H, Kaji S, Hirayama S, Miida T, Kondou H, Ihara H, Yagi M, Kizaki Z, Bessho K, Kodama T, Iijima K, Saheki T, Yorifuji T, Honda A
    • Journal Title

      Mol. Genet. Metab.

      Volume: 120 Issue: 3 Pages: 207-212

    • DOI

      10.1016/j.ymgme.2016.12.011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K00849, KAKENHI-PROJECT-15K09595, KAKENHI-PROJECT-26461609, KAKENHI-PROJECT-15K08624, KAKENHI-PROJECT-26461644
  • [Journal Article] Sodium-coupled Neutral Amino Acid Transporter 4 Functions as a Regulator of Protein Synthesis during Liver Development2013

    • Author(s)
      Hiroki Kondou, Masanobu Kawai, Kanako Tachikawa, Akihito Kimoto, Masayo Yamagata, Tomoko Koinuma, Miwa Yamazaki, Masahiro Nakayama, Sotaro Mushiake, Keiichi Ozono, Toshimi Michigami
    • Journal Title

      Hepatology Research

      Volume: in press Pages: 0-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591566
  • [Journal Article] Vinculin functions as regulator of chondrogenesis.2012

    • Author(s)
      Koshimizu T, Kawai M, Kondou H, Tachikawa K, Sakai N, Ozono K, Michigami T.
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 19 Pages: 15760-15775

    • DOI

      10.1074/jbc.m111.308072

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591227, KAKENHI-PROJECT-23591526, KAKENHI-PROJECT-23591566, KAKENHI-PROJECT-24390264
  • [Journal Article] Humoral immunity is involved in the development of pericentral fibrosis after pediatric live donor liver transplantation.2012

    • Author(s)
      Yamada H, Kondou H, Kimura T, Ikeda K, Tachibana M, Hasegawa Y, Kiyohara Y, Ueno T, Miyoshi Y, Mushiake S, Ozono K
    • Journal Title

      Pediatric Transplantation

      Volume: 16 Issue: 8 Pages: 858-865

    • DOI

      10.1111/j.1399-3046.2012.01781.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591566
  • [Journal Article] Major role of apolipoprotein B in cycloheximide-induced acute hepatic steatosis in mice2011

    • Author(s)
      Murakami M, Besshol K, Mushiake S, Kondou H, Miyoshi Y, Ozono K
    • Journal Title

      Hepatology Research

      Volume: 41(5) Issue: 5 Pages: 446-454

    • DOI

      10.1111/j.1872-034x.2011.00791.x

    • NAID

      10031144110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591321, KAKENHI-PROJECT-23591566
  • [Journal Article] Prospective Isolation and Characterization of Bipotent Progenitor Cells in Early Mouse Liver Development.2011

    • Author(s)
      Okada K, Kamiya S, Ito K, Yanagida A, Ito H, Kondou H, Nishina H, Nakauchi H
    • Journal Title

      Stem Cells Dev

      Volume: 18

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591566
  • [Journal Article] PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3β in osteoblastic Saos-2 cells.2008

    • Author(s)
      Suzuki A, Ozono K, Kubota T, Kondou H, Tachikawa K, Michigami T.
    • Journal Title

      J Cell Biochem 104

      Pages: 314-317

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590921
  • [Journal Article] Intraperitoneal administration of recombinant receptor-associated protein causes phosphaturia via an alteration in subcellular distribution of the renal sodium2005

    • Author(s)
      Yamagata M, Ozono K, Hashimoto Y, Miyauchi Y, Kondou H, Michigami T
    • Journal Title

      Journal of American Society of Nephrology 16・8

      Pages: 2338-2345

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590809
  • [Journal Article] Intraperitoneal administration of recombinant receptor-associated protein cause phosphaturia via an alteration in subcellular distribution of the renal sodium phosphate co-transporter.2005

    • Author(s)
      Yamagata M, Ozono K, Hashimoto Y, Miyauchi Y, Kondou H, Michigami T.
    • Journal Title

      Journal of American Society of Nephrology 16・8

      Pages: 2338-2345

    • Data Source
      KAKENHI-PROJECT-16590809
  • [Journal Article] Intraperitoneal administration of recombinant receptor-associated protein causes phosphaturia via an alteration in subcellular distribution of the renal sodium phosphate co-transporter.2005

    • Author(s)
      Yamagata M, Ozono K, Hashimoto Y, Miyauchi Y, Kondou H, Michigami T.
    • Journal Title

      J Am Soc Nephrol 16

      Pages: 2338-2345

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590809
  • [Presentation] Dissociation Between Clinical Evaluation and PELD Score in The Setting of Pediatric Living-Related Liver Transplantation in JAPAN: A 18 Year Single Center Experience.2016

    • Author(s)
      Bessho K, Hasegawa Y, Fukuda H, Hagiwara K, Ueno T, Miyoshi Y, Kondou H, Mushiake S, Okuyama H, Ozono K.
    • Organizer
      The International Liver Congress 2016
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2016-04-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461609
  • [Presentation] 胆道閉鎖症患者の肝臓では胆汁酸生合成律速酵素CYP7A1の抑制機構の破綻が起きている2015

    • Author(s)
      長谷川泰浩, 近藤宏樹, 別所一彦, 川井正信, 安田紀恵, 上野豪久, 里村宜紀, 小西暁子, 木村武司, 倉川佳世, 三善陽子, 道上敏美, 大薗恵一
    • Organizer
      第42回日本小児栄養消化器肝臓学会
    • Place of Presentation
      広島
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-26461609
  • [Presentation] 胆道閉鎖症患者の肝臓では胆汁酸生合成律速酸素CYP7A1の抑制機構の破綻が起きている2015

    • Author(s)
      長谷川泰浩, 近藤宏樹, 別所一彦, 川井正信, 安田紀恵, 上野豪久, 里村宜紀, 小西暁子, 木村武司, 倉川佳世, 三善陽子, 道上敏美, 大薗恵一
    • Organizer
      第32回日本小児肝臓研究会
    • Place of Presentation
      鳥取
    • Year and Date
      2015-07-25
    • Data Source
      KAKENHI-PROJECT-26461609
  • [Presentation] A case of chronic rejection after liver transplantation for acute liver failure2015

    • Author(s)
      Zenitani S, Bessho K, Kondou H, Hasegawa Y, Yasuda K, Konishi A, Satomura Y, Miyoshi Y, Ueno T, Ozono K
    • Organizer
      11th Asian Society for Pediatric Research
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461609
  • [Presentation] 胆道閉鎖症患者の肝臓では胆汁酸合成律速酵素CYP7A1の抑制機構の破綻が起きている2015

    • Author(s)
      長谷川泰浩、近藤宏樹
    • Organizer
      第32回日本小児肝臓研究会
    • Place of Presentation
      鳥取県米子市 鳥取大学医学部臨床講義棟3階431講義室
    • Year and Date
      2015-07-25
    • Data Source
      KAKENHI-PROJECT-26461608
  • [Presentation] Dysregulation of Cholesterol 7 alpha-hydroxylase (CYP7A1) is involved in the abnormal bile acid synthesis in livers from biliary atresia (BA) children2014

    • Author(s)
      Hasegawa Y, Kondou H, Bessho K, Kawai M, Nakao K, Ueno T, Satomura Y, Konishi A, Kimura T, Ikeda K, Tachibana M, Miyoshi Y, Michigami T, Ozono K
    • Organizer
      The Liver Meeting 2014
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2014-11-10
    • Data Source
      KAKENHI-PROJECT-26461609
  • [Presentation] Fibroblast growth factor 19 was aberrantly expressed in cholestatic hepatocytes, and its signal pathways were inappropriately down-regulated in biliary atresia children.2013

    • Author(s)
      Hasegawa Y, Kondou H, Kawai M, Ueno T, Miyahara Y, Konishi A, Nakao K, Kimura T, Ikeda K, Tchibana M, Bessho K, Miyoshi Y, Michigami T, Ozono K.
    • Organizer
      AASLD THE LIVER MEETING
    • Place of Presentation
      Wahington DC, USA
    • Data Source
      KAKENHI-PROJECT-23591566
  • [Presentation] 小児胆汁うっ滞性疾患ではFGF19は肝細胞に発現し胆汁酸制御に関与する2013

    • Author(s)
      長谷川泰浩,近藤宏樹,宮原由起,三善陽子
    • Organizer
      日本肝臓学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591566
  • [Presentation] Fibroblast growth factor 19 was aberrantly expressed in cholestatic hepatocytes, and its signal pathways were inappropriately downregulated in biliary atresia children.2013

    • Author(s)
      Hasegawa Y, Kondou H, Kawai M, Ueno T, Miyahara Y, Konishi A, Nakao K, Tachibana M, Kimura T, Ikeda K, Bessho K, Miyoshi Y, Michigami T, Ozono K
    • Organizer
      肝細胞研究会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23591566
  • [Presentation] 肝発生過程において転写因子HNF4αはナトリウム依存性中性アミノ酸トランスポーターSNAT4を介して蛋白合成を促進する2010

    • Author(s)
      近藤宏樹
    • Organizer
      第46回 日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-20591294
  • [Presentation] 肝発生過程において転写因子HNF4αはナトリウム依存性中性アミノ酸トランスポーターSNAT4を介して蛋白合成を促進する2010

    • Author(s)
      近藤宏樹
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-20591294
  • [Presentation] 肝特異的アミノ酸トランスポーターSNAT4の肝発生過程における発現制御と機能解析2009

    • Author(s)
      近藤宏樹
    • Organizer
      第16回肝細胞研究会
    • Place of Presentation
      山形テルサ (山形市)
    • Year and Date
      2009-06-27
    • Data Source
      KAKENHI-PROJECT-20591294
  • [Presentation] 肝特異的アミノ酸トランスポーターSNAT4の肝発生過程における発現制御と機能解析2009

    • Author(s)
      近藤宏樹
    • Organizer
      第16回肝細胞研究会
    • Place of Presentation
      山形市
    • Year and Date
      2009-06-27
    • Data Source
      KAKENHI-PROJECT-20591294
  • [Presentation] Akihito KiToshimi Michigami The Sodium-coupled Neutral Amino AcTransporter (SNAT) 4 Is Expressed in Developing Mouse Liver and Regulated by Hepatocyte Nuclear Factor (Hnf) 4α.2008

    • Author(s)
      Hiroki Kondou, Kanako Tachikawa, Masayo Yamagata
    • Organizer
      FASEB Summer Research Conferenc 2008
    • Place of Presentation
      Snowmass Village, CO, USA
    • Year and Date
      2008-08-06
    • Data Source
      KAKENHI-PROJECT-20591294
  • [Presentation] The Sodium-coupled Neutral Amino Acid Transporter (SNAT) 4 Is Expressed in Developing Mouse Liver and Regulated by Hepatocyte Nuclear Factor (Hnf) 4α2008

    • Author(s)
      近藤宏樹
    • Organizer
      FASEB Summer Research Conferences Liver Growth, Development and Disease
    • Place of Presentation
      アメリカ合衆国コロラド州スノーマス
    • Year and Date
      2008-08-06
    • Data Source
      KAKENHI-PROJECT-20591294
  • [Presentation] The sodium{-coupledNeutral Amino Acid Transporter (SNAT) 4 Is Expressed In Developing Mouse Liver And Regulated By Hepatocyte Nuclear Factor (HNF)4α2007

    • Author(s)
      近藤 宏樹
    • Organizer
      米国肝臓学会
    • Place of Presentation
      米国・ボストン
    • Year and Date
      2007-11-06
    • Data Source
      KAKENHI-PROJECT-18790753
  • 1.  MICHIGAMI Toshimi (00301804)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 2.  MUSHIAKE Sotaro (90291947)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  Bessho Kazuhiko (80423169)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 4.  WADA Kazuko (30294094)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  Okuda Masumi (40531091)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  KAMIYA Shigeru (10177587)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KIKUCHI Shogo (40224901)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  FUKUDA Yoshihiro (60148640)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  OSAKI Takako (90255406)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  OZONO Keiichi (20270770)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  佐竹 真 (70399153)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  前川 講平 (80412005)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  HONDA Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  MIYOSHI Yoko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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