Oonuma Kei 大沼圭

… Alternative Names

OHNUMA Kei 大沼圭

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Researcher Number	10396872
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 非常勤講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 順天堂大学, 大学院医学研究科, 非常勤講師 2012 – 2020: 順天堂大学, 医学(系)研究科(研究院), 准教授 2015: 順天堂大学, 医学部, 准教授 2013: 順天堂大学, 医学研究科, 准教授 2007 – 2011: The University of Tokyo, Instifute of Medical Science, Assistant Professor … More 2009: 東大, 医科学研究所, 助教 2006: 東京大学, 医科学研究所, 助手 2005: 東京大学, 医科学研究所, 産学官連携研究員 Less
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Respiratory organ internal medicine Except Principal Investigator Basic Section 49030:Experimental pathology-related / 膠原病・アレルギー・感染症内科学 / Hematology / Collagenous pathology/Allergology / Infectious disease medicine
Keywords	Principal Investigator CD26 / 造血幹細胞移植 / GVHD / Caveolin-1 / T細胞 / 線維化 / IL-26 / 慢性GVHD / 移植片対宿主病 / caveolin-1 … More / 共刺激 / 臓器線維症 / 肺線維症 / 小児血液学 / 移植免疫学 / DPP4 / ソマトスタチン / dipeptydil peptidase 4 / CD26抗体療法 / ペリオスチン / ソマトスタチン受容体 / 悪性中皮腫 / 移植免疫 / CTLA4-Ig / CD8 / 骨髄移植 / DPPIV / CD26/DPPIV / CaveoIin-1 / CD28 / 臍帯血 / 抗原提示細胞 / NF-κB / IRAK-1 / Tollip … More Except Principal Investigator 自己免疫疾患 / CD26 / 炎症性腸疾患 / 慢性炎症 / IL-26 / 慢性GVHD / ヒト免疫 / Sjogren's syndrome / Ro52 / ヒト化CD26抗体 / 共刺激分子 / 臨床免疫学 / 核酸 / 抗体療法 / 移植片対宿主病 / 関節炎 / 関節炎モデル / IL-26中和抗体 / 炎症性サイトカイン / DPPⅣ / 好酸球 / 好中球 / 炎症 / HMGB1 / GVHD / 小児血液学 / 血液免疫学 / 移植免疫学 / BTLA / LAG-3 / SLE / 腫瘍免疫 / 免疫制御 / 悪性胸膜中皮腫 / 全身性エリテマトーデス / 免疫チェックポイント分子 / IL-10 / T細胞 / CD26/DPPIV / Autoimmune Disease / Sjogren'S syndrome / ⑦ CD26単クローン抗体 / ⑤ ヒト化CD26抗体 / ④ 重症呼吸器感染症 / ② コロナウイルス / ① MERS感染症 / トランスジェニックマウス / (1) MERS感染症 / エピトープ / アポトーシス / CD26単クローン抗体 / 重症呼吸器感染症 / CD26/DPPⅣ / コロナウイルス / MERS感染症 / IRAK-1 / Tollip / Caveolin-1 / CARMA-1 / 共刺激リガンド / CD86 / メモリーT細胞 / エフェクターT細胞 / TIA-1陽性T細胞 / CD26陽性T細胞 / 異種GVHDマウス / DPPIV酵素 / caveolin.1 / CD28 / Xeno-GVHD / CD8T細胞 / DPPIV / caveolin-1 / リウマチ学 / 膠原病 Less

Molecular understanding of an innovative therapy for chronic inflammatory diseases targeting human Th17 cytokine IL-26
- Principal Investigator
  
  森本幾夫
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Juntendo University
Understanding of detailed pathology and development of novel molecular targeted therapy for the treatment of refractory chronic inflammatory diseases based on the inflammatory cytokine IL-26
- Principal Investigator
  
  Morimoto Chikao
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Juntendo University
Scientific research on development of anti-fibrotic agent targeting multi-organ profibrotic factor IL-26 in GVHDPrincipal Investigator
- Principal Investigator
  
  Kei Ohnuma
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Juntendo University
Molecular understanding of CD26-mediated immune regulatory mechanism and development of novel molecular targeted therapy for the treatment of refractory autoimmune diseases
- Principal Investigator
  
  Morimoto Chikao
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Juntendo University
Prevention of chronic GVHD onset by HMGB1 inhibiton of DPP4
- Principal Investigator
  
  IWAO NORIAKI
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Large molecular complex of cell surface in malignant pleural mesotheliom as a novel treatment targetPrincipal Investigator
- Principal Investigator
  
  OHNUMA Kei
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Juntendo University
Mechanism of lung fibrosis in chronic GVHDPrincipal Investigator
- Principal Investigator
  
  OHNUMA Kei
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Juntendo University
Role of CD26 molecule in the infection of MERS(Middle East respiratory syndrome) virus and development of new therapy
- Principal Investigator
  
  MORIMOTO CHIKAO
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Juntendo University
新規T細胞共刺激分子CD26ーカベオリンを標的とする免疫療法開発の基礎的研究Principal Investigator
- Principal Investigator
  
  大沼圭
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo
Scientific research of transplantation tolerance targeting CD26/caveolin-1 costimulation pathwayPrincipal Investigator
- Principal Investigator
  
  OHNUMA Kei
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (S)
- Research Field
  
  Pediatrics
- Research Institution
  Juntendo University
  The University of Tokyo
Scientific research for developing a novel immunotherapy targetinginteraction of CD26 and its ligandPrincipal Investigator
- Principal Investigator
  
  OHNUMA Kei
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo
Analysis of the Ro52's function and structure and biological significance of autoimmune disease
- Principal Investigator
  
  YAMOCHI Tadanori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Basic Approach for the Development of Molecular Target Therapy for Autoimmune Diseases and Immune-Mediated Disorders.
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
造血幹細胞移植の合併症克服を目指したCD26による分子標的療法に関する基礎的研究Principal Investigator
- Principal Investigator
  
  大沼圭
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo

[Book] Regulation of proliferation of malignant mesothelioma cells by CD26-cyclophilin A molecular complex. In: Advanced in Medicine and Biology.2019
- Author(s)
  Okamoto T, Hatano R, Nakano K, Yamada T, Yamazaki H, Kaneko Y, Dang NH, Morimoto C, Ohnuma K.
- Total Pages
  283
- Publisher
  Nova Science Publishers, Inc.
- ISBN
  9781536166903
- Data Source
  KAKENHI-PROJECT-18H02782
[Book] Advances in Medicine and Biology2018
- Author(s)
  Hatano R, Ohnuma K, Yamada T, Okamoto T, Komiya E, Otsuka H, Itoh T, Yamazaki H, Iwao N, Kaneko Y, Dang NH, Morimoto C.
- Total Pages
  45
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-16H05345
[Book] THE USE OF THE HUMANIZED ANTI-CD26 MONOCLONAL ANTIBODY YS110 AS A NOVEL TARGETED THERAPY FOR REFRACTORY CANCERS AND IMMUNE DISORDERS2018
- Author(s)
  Hating R, Ohnuma K, Yamada T, Okamoto T, Kaneko Y, Dang NH, Morimoto C.
- Total Pages
  272
- Publisher
  Nova Scientific Publishers
- ISBN
  9781536133486
- Data Source
  KAKENHI-PROJECT-18H02782
[Book] Horizons in Cancer Research2017
- Author(s)
  Ohnuma K, Hatano R, Yamazaki H, Kaneko Y, Dang NH, Morimoto C.
- Total Pages
  33
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-16H05345
[Book] Horizons in Cancer Research2017
- Author(s)
  Ohnuma K, Hatano R, Yamazaki H, KanekoY, Dang NH, Morimoto C.
- Total Pages
  212
- Publisher
  Nova Science Publisher
- ISBN
  9781536105124
- Data Source
  KAKENHI-PROJECT-15H04879
[Book] Horizons in Cancer Research2017
- Author(s)
  Ohnuma, K. Hatano, R. Yamazaki, H. Kaneko, Y. Dang, N. H. Morimoto, C.
- Total Pages
  212
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-15H04879
[Book] Horizons in Cancer Research2017
- Author(s)
  Ohnuma, K. Hatano, R. Yamazaki, H. Kaneko, Y. Dang, N. H. Morimoto, C.
- Total Pages
  212
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-15K15324
[Book] A New Horizon in Malignant Pleural Mesothelioma Management, Horizons in Cancer Researc2016
- Author(s)
  Ohnuma K, Hatano R, Yamazaki H, KanekoY, Dang NH, Morimoto C1.Ohnuma K, Hatano R, Yamazaki H, KanekoY, Dang NH, Morimoto C
- Total Pages
  220
- Publisher
  Nova Science Publishers,Inc
- Data Source
  KAKENHI-PROJECT-16H05345
[Book] Dipeptidyl peptidase in autoimmune pathophysiology. In : Makowski GS, eds. Advances in Clinical Chemistry Vol 532011
- Author(s)
  Ohnuma K, Hosono O, Dang NH, Morimoto C
- Publisher
  Burlington, MA, USA : Academic Press
- Data Source
  KAKENHI-PROJECT-21679005
[Book] Advances in Clinical Chemistry Vol.532011
- Author(s)
  Ohnuma K, Morimoto C, et. al.
- Total Pages
  184
- Publisher
  Elsevier Publishing
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] Functional Roles of CD26/DPP4 in Bleomycin-Induced Pulmonary Hypertension Associated with Interstitial Lung Disease2024
- Author(s)
  Okaya Tadasu、Kawasaki Takeshi、Sato Shun、Koyanagi Yu、Tatsumi Koichiro、Hatano Ryo、Ohnuma Kei、Morimoto Chikao、Kasuya Yoshitoshi、Hasegawa Yoshinori、Ohara Osamu、Suzuki Takuji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 2 Pages: 748-748
- DOI
  10.3390/ijms25020748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16163, KAKENHI-PROJECT-23K06501, KAKENHI-PROJECT-23K27395
[Journal Article] Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury2024
- Author(s)
  Sato Shun、Kawasaki Takeshi、Hatano Ryo、Koyanagi Yu、Takahashi Yukiko、Ohnuma Kei、Morimoto Chikao、Dudek Steven M.、Tatsumi Koichiro、Suzuki Takuji
- Journal Title
  
  American Journal of Physiology-Lung Cellular and Molecular Physiology
  
  Volume: - Issue: 5 Pages: L562-L573
- DOI
  10.1152/ajplung.00392.2022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16163, KAKENHI-PROJECT-23K06501, KAKENHI-PROJECT-23K27395
[Journal Article] Functional roles of <scp>CD26</scp> / <scp>DPP4</scp> in bleomycin‐induced pulmonary fibrosis2023
- Author(s)
  Koyanagi Yu、Kawasaki Takeshi、Kasuya Yoshitoshi、Hatano Ryo、Sato Shun、Takahashi Yukiko、Ohnuma Kei、Morimoto Chikao、Dudek Steven M.、Tatsumi Koichiro、Suzuki Takuji
- Journal Title
  
  Physiological Reports
  
  Volume: 11 Issue: 6
- DOI
  10.14814/phy2.15645
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16163, KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-20K07683, KAKENHI-PROJECT-23K24337
[Journal Article] Humanized anti-IL-26 monoclonal antibody as a novel targeted therapy for chronic graft-versus-host disease.2022
- Author(s)
  Hatano R, Itoh T, Otsuka H, Saeki H, Yamamoto A, Song D, Shirakawa Y, Iyama S, Sato T, Iwao N, Harada N, Aune TM, Dang NH, Kaneko Y, Yamada T, Morimoto C, Ohnuma K.
- Journal Title
  
  Am J Transplant.
  
  Volume: 22 Pages: 2804-2820
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03471
[Journal Article] Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV2022
- Author(s)
  Komiya Eriko、Tominaga Mitsutoshi、Hatano Ryo、Kamikubo Yuji、Toyama Sumika、Sakairi Hakushun、Honda Kotaro、Itoh Takumi、Kamata Yayoi、Tsurumachi Munehiro、Kishi Ryoma、Ohnuma Kei、Sakurai Takashi、Morimoto Chikao、Takamori Kenji
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 149 Issue: 3 Pages: 1085-1096
- DOI
  10.1016/j.jaci.2021.08.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-19K08756, KAKENHI-PROJECT-20K07683, KAKENHI-PROJECT-20K07765, KAKENHI-PROJECT-20K08680, KAKENHI-PROJECT-21K16307, KAKENHI-PROJECT-20K22745, KAKENHI-PROJECT-23K20320, KAKENHI-PROJECT-23K24217
[Journal Article] IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells2021
- Author(s)
  Itoh Takumi、Hatano Ryo、Horimoto Yoshiya、Yamada Taketo、Song Dan、Otsuka Haruna、Shirakawa Yuki、Mastuoka Shuji、Iwao Noriaki、Aune Thomas M.、Dang Nam H.、Kaneko Yutaro、Okumura Ko、Morimoto Chikao、Ohnuma Kei
- Journal Title
  
  Cell Death and Disease
  
  Volume: 12 Issue: 6 Pages: 520-520
- DOI
  10.1038/s41419-021-03787-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-20K07683, KAKENHI-PROJECT-21K16389
[Journal Article] CD26/Dipeptidyl Peptidase IV and Its Multiple Biological Functions2021
- Author(s)
  Pan Kelsey、Ohnuma Kei、Morimoto Chikao、Dang Nam H
- Journal Title
  
  Cureus
  
  Volume: 13
- DOI
  10.7759/cureus.13495
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02782, KAKENHI-PROJECT-20H03471
[Journal Article] Serum soluble CD26/DPP4 titer variation is a potential prognostic biomarker in cancer therapy with a humanized anti-CD26 antibody.2021
- Author(s)
  Kaneko Y, Hatano R, Hirota N, Isambert N, Trillet-Lenoir V, You B, Alexandre J, Zalcman G, Valleix F, Podoll T, Umezawa Y, Takao S, Iwata S, Hosono O, Taguchi T, Yamada T, Dang NH, Ohnuma K, Angevin E, Morimoto C.
- Journal Title
  
  Biomark Res
  
  Volume: 9 Issue: 1 Pages: 21-21
- DOI
  10.1186/s40364-021-00273-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07683, KAKENHI-PROJECT-18H02782, KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-19K22542
[Journal Article] Characterization of novel anti-IL-26 neutralizing monoclonal antibodies for the treatment of inflammatory diseases including psoriasis.2019
- Author(s)
  Hatano R, Itoh T, Otsuka H, Okamoto S, Komiya E, Iwata S, Aune TM, Dang NH, Kuwahara-Arai K, Ohnuma K, Morimoto C.
- Journal Title
  
  MAbs
  
  Volume: 11 Pages: 1428-1442
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02782
[Journal Article] Rheumatic diseases associated with immune checkpoint inhibitors in cancer immunotherapy.2019
- Author(s)
  Ohnuma K, Hatano R, Dang NH, Morimoto C.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 印刷中 Issue: 5 Pages: 721-732
- DOI
  10.1080/14397595.2018.1532559
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10008, KAKENHI-PROJECT-16H05345
[Journal Article] Rheumatic diseases associated with immune checkpoint inhibitors in cancer immunotherapy.2019
- Author(s)
  Ohnuma K, Hatano R, Dang NH, Morimoto C.
- Journal Title
  
  Modern Rheumatology
  
  Volume: 29 Pages: 721-732
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02782
[Journal Article] Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens2019
- Author(s)
  Hatano R, Yamada T, Madokoro H, Otsuka H, Komiya E, Itoh T, Narita Y, Iwata S, Yamazaki H, Matsuoka S, Dang NH, Morimoto C
- Journal Title
  
  PLoS ONE
  
  Volume: 14 Issue: 6 Pages: e0218330-e0218330
- DOI
  10.1371/journal.pone.0218330
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22542, KAKENHI-PROJECT-17K16353, KAKENHI-PROJECT-18H02782, KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-17K10008, KAKENHI-PROJECT-19K21278
[Journal Article] GVHDと慢性炎症2019
- Author(s)
  岩尾憲明　大沼圭　大塚春奈　波多野良　古宮栄利子　伊藤匠　森本幾夫
- Journal Title
  
  別冊BioClinica
  
  Volume: 8 Pages: 128-133
- Data Source
  KAKENHI-PROJECT-16K09878
[Journal Article] DPP8 is a novel therapeutic target for multiple myeloma.2019
- Author(s)
  Sato T, Tatekoshi A, Takada K, Iyama S, Kamihara Y, Jawaid P, Rehman MU, Noguchi K, Kondo T, Kajikawa S, Arita K, Wada A, Murakami J, Arai M, Yasuda I, Dang NH, Hatano R, Iwao N, Ohnuma K, Morimoto C.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 18094-18094
- DOI
  10.1038/s41598-019-54695-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02782, KAKENHI-PROJECT-17K10008
[Journal Article] Biological effects of IL-26 on T cell-mediated skin inflammation, including psoriasis.2019
- Author(s)
  Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune TM, Dang NH, Matsuoka S, Naito H, Tominaga M, Takamori K, Morimoto C, Ohnuma K.
- Journal Title
  
  J Invest Dermatol
  
  Volume: 139 Issue: 4 Pages: 878-889
- DOI
  10.1016/j.jid.2018.09.037
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10008, KAKENHI-PROJECT-17K16353, KAKENHI-PROJECT-16H05345, KAKENHI-PROJECT-19K21278, KAKENHI-PROJECT-18H02782, KAKENHI-PROJECT-18K07396
[Journal Article] A novel role for CD26/dipeptidyl peptidase IV as a therapeutic target in selected immune disorders and cancers2018
- Author(s)
  Ohnuma K, Hatano R, Komiya E, Otsuka H, Itoh T, Iwao N, Kaneko Y, Yamada T, Dang NH, Morimoto C
- Journal Title
  
  Front Biosci
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05345
[Journal Article] Targeting CD26 suppresses proliferation of malignant mesothelioma cell via downmodulation of ubiquitin-specific protease 22.2018
- Author(s)
  Okamoto T, Yamazaki H, Hatano R, Yamada T, Kaneko Y, Xu CW, Dang NH, Ohnuma K, Morimoto C.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 504 Issue: 2 Pages: 491-498
- DOI
  10.1016/j.bbrc.2018.08.193
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10008, KAKENHI-PROJECT-16H04714, KAKENHI-PROJECT-16H05345, KAKENHI-PROJECT-18H02782
[Journal Article] Caveolin-1, a binding protein of CD26, is essential for the anti-inflammatory effects of dipeptidyl peptidase-4 inhibitors on human and mouse macrophages2018
- Author(s)
  Hiromura Munenori、Nohtomi Kyoko、Mori Yusaku、Kataoka Hideo、Sugano Marika、Ohnuma Kei、Kuwata Hirotaka、Hirano Tsutomu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 1 Pages: 223-229
- DOI
  10.1016/j.bbrc.2017.11.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17357, KAKENHI-PROJECT-16H05345, KAKENHI-PROJECT-18H02782, KAKENHI-PROJECT-18K09558
[Journal Article] A novel role for CD26/dipeptidyl peptidase IV as a therapeutic target2018
- Author(s)
  Ohnuma K, Hatano R, Komiya E, Otsuka H, Itoh T, Iwao N, Kaneko Y, Yamada T, Dang NH, Morimoto C.
- Journal Title
  
  Front Biosci
  
  Volume: 23 Issue: 9 Pages: 1754-1779
- DOI
  10.2741/4671
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02782
[Journal Article] First-in-Human phase 1 of YS110, a monoclonal antibody directed against CD26 in advanced CD26-expressing cancers2017
- Author(s)
  Angevin E, Isambert N, Trillet-Lenoir V, You B, Alexandre J, Zalcman G, Vielh P, Farace F, Valleix F, Podoll T, Kuramochi Y, Miyashita I, Hosono O, Dang NH, Ohnuma K, Yamada T, Kaneko Y, Morimoto C
- Journal Title
  
  Br.J.Cancer
  
  Volume: 62 Pages: 1-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05345
[Journal Article] A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus2017
- Author(s)
  Komiya, E. Hatano, R. Otsuka, H. Itoh, T. Yamazaki, H. Yamada, T. Dang, N. H. Tominaga, M. Suga, Y. Kimura, U. Takamori, K. Morimoto, C. Ohnuma, K.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 印刷中 Issue: 3 Pages: 212-221
- DOI
  10.1016/j.jdermsci.2017.03.005
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04879, KAKENHI-PROJECT-16H04714, KAKENHI-PROJECT-16H05345, KAKENHI-PROJECT-15K15324, KAKENHI-PROJECT-14J12067, KAKENHI-PROJECT-17K10008, KAKENHI-PROJECT-17K16353, KAKENHI-PROJECT-26830114, KAKENHI-PROJECT-26860760, KAKENHI-PROJECT-15K08680, KAKENHI-PROJECT-16K08997
[Journal Article] Identification of senescent cell surface targetable protein DDP4.2017
- Author(s)
  71.Kim KM, Noh JH, Bodogai M, Martindale JL, Yang X, Indig FE, Basu SK, Ohnuma K, Morimoto C, Johnson PF, Biragyn A, Abdelmohsen K, Gorospe M.
- Journal Title
  
  Genes Dev
  
  Volume: 31 Issue: 15 Pages: 1529-1534
- DOI
  10.1101/gad.302570.117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04879, KAKENHI-PROJECT-16H05345
[Journal Article] Current and Emerging Therapy for Malignant Pleural Mesothelioma: Focus on CD26/Dipeptidyl Peptidase IV as a Therapeutic Target.2017
- Author(s)
  Doonan BP, Ohnuma K, Dang LH, Morimoto C, Dang NH.
- Journal Title
  
  Current Cancer Therapy Reviews.
  
  Volume: 13 Pages: 1-13
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05345
[Journal Article] First-in-human phase 1 of YS110, a monoclonal antibody directed against CD26 in advanced CD26-expressing cancers2017
- Author(s)
  Angevin, E. Isambert, N. Trillet-Lenoir, V. You, B. Alexandre, J. Zalcman, G. Vielh, P. Farace, F. Valleix, F. Podoll, T. Kuramochi, Y. Miyashita, I. Hosono, O. Dang, N. H. Ohnuma, K. Yamada, T. Kaneko, Y. Morimoto, C.
- Journal Title
  
  Br J Cancer
  
  Volume: 印刷中 Issue: 9 Pages: 1-9
- DOI
  10.1038/bjc.2017.62
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04879, KAKENHI-PROJECT-16H04714, KAKENHI-PROJECT-15K15324, KAKENHI-PROJECT-16H05345
[Journal Article] Focus on CD26/Dipeptidyl Peptidase IV as a Therapeutic Target.2017
- Author(s)
  Doonan BP, Ohnuma K, Dang LH, Morimoto C, Dang NH.
- Journal Title
  
  Current Cancer Therapy Reviews
  
  Volume: 13 Issue: 2 Pages: 1-13
- DOI
  10.2174/1573394713666170907160734
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04879
[Journal Article] Inhibition of VEGF-dependent angiogenesis by the anti-CD82 monoclonal antibody 4F9 through regulation of lipid raft microdomains2016
- Author(s)
  Nomura, S. Iwata, S. Hatano, R. Komiya, E. Dang, N. H. Iwao, N. Ohnuma, K. Morimoto, C.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 474 Issue: 1 Pages: 111-7
- DOI
  10.1016/j.bbrc.2016.04.081
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04879, KAKENHI-PROJECT-16H05345, KAKENHI-PROJECT-15K15324, KAKENHI-PROJECT-26830114, KAKENHI-PROJECT-26860760, KAKENHI-PROJECT-14J12067
[Journal Article] Development of New Therapy for Malignant Mesothelioma Based on CD26 Molecule2016
- Author(s)
  Morimoto, C. Ohnuma, K.
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 43 Pages: 855-62
- Data Source
  KAKENHI-PROJECT-15H04879
[Journal Article] 標的別分子標的薬６）モノクローナル抗体2016
- Author(s)
  大沼圭、森本幾夫
- Journal Title
  
  腎臓内科
  
  Volume: 4 Pages: 52-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05345
[Journal Article] Development of New Therapy for Malignant Mesothelioma Based on CD26 Molecule2016
- Author(s)
  Morimoto, C. Ohnuma, K.
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 43 Pages: 855-62
- Data Source
  KAKENHI-PROJECT-15K15324
[Journal Article] CD26抗体を基盤とするトランスレーショナルリサーチ：悪性中皮腫の新規治療法開発を目指して2016
- Author(s)
  森本幾夫、大沼圭
- Journal Title
  
  The Japanese Journal of Pediatric Hematology / Oncology
  
  Volume: 53 Issue: 3 Pages: 182-188
- DOI
  10.11412/jspho.53.182
- NAID
  130005606021
- ISSN
  2187-011X, 2189-5384
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05345
[Journal Article] Role of IL-26+CD26+CD4 T Cells in Pulmonary Chronic Graft-Versus-Host Disease and Treatment with Caveolin-1-Ig Fc Conjugate2016
- Author(s)
  Ohnuma, K. Hatano, R. Itoh, T. Iwao, N. Dang, N. H. Morimoto, C.
- Journal Title
  
  Crit Rev Immunol
  
  Volume: 36 Issue: 3 Pages: 239-267
- DOI
  10.1615/critrevimmunol.2016018772
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04879, KAKENHI-PROJECT-16H05345, KAKENHI-PROJECT-15K15324, KAKENHI-PROJECT-26860760, KAKENHI-PROJECT-14J12067
[Journal Article] CD26-mediated induction of EGR2 and IL-10 as potential regulatory mechanism for CD26 costimulatory pathway.2015
- Author(s)
  Hatano R, Ohnuma K, Otsuka H, Komiya E, Taki I, Iwata S, Dang NH, Okumura K, Morimoto C.
- Journal Title
  
  J Immunol.
  
  Volume: Vol 194 Issue: 3 Pages: 960-72
- DOI
  10.4049/jimmunol.1402143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J12067, KAKENHI-PROJECT-24591442, KAKENHI-PROJECT-26670486, KAKENHI-PROJECT-26830114, KAKENHI-PROJECT-26860760, KAKENHI-PROJECT-15K15324, KAKENHI-PROJECT-15H04879, KAKENHI-PROJECT-26293087
[Journal Article] Remission of remitting seronegative symmetrical synovitis with pitting edema after unrelated cord blood transplantation for myelodysplastic syndrome.2015
- Author(s)
  Ishii H, Konuma T, Ohnuma K, Hosono O, Tanaka H, Kato S, Tojo A, Takahashi S.
- Journal Title
  
  Ann Hematol.
  
  Volume: 95 Issue: 3 Pages: 523-524
- DOI
  10.1007/s00277-015-2555-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04879, KAKENHI-PROJECT-15K15324
[Journal Article] Deep venous thrombosis was not detected after total knee arthroplasty in Japanese patients with haemophilia.2015
- Author(s)
  Takedani H, Ohnuma K, Hirose J.
- Journal Title
  
  Haemophilia
  
  Volume: 21 Issue: 5 Pages: 585-588
- DOI
  10.1111/hae.12643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15324, KAKENHI-PROJECT-15H04879, KAKENHI-PROJECT-26293251
[Journal Article] DPP4 in anti-tumor immunity: going beyond the enzyme.2015
- Author(s)
  Ohnuma K, Hatano R, Morimoto C.
- Journal Title
  
  Nat Immunol.
  
  Volume: 16 Issue: 8 Pages: 791-2
- DOI
  10.1038/ni.3210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26860760, KAKENHI-PROJECT-15H04879, KAKENHI-PROJECT-14J12067, KAKENHI-PROJECT-26670486
[Journal Article] Modulation of immunological responses and amelioration of collagen-induced arthritis by the novel roxithromycin derivative 5-I.2015
- Author(s)
  Otsuki N, Iwata S, Yamada T, Hosono O, Dang NH, Hatano R, Ohnuma K, Morimoto C.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 25 Issue: 4 Pages: 562-70
- DOI
  10.3109/14397595.2014.983262
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860760, KAKENHI-PROJECT-14J12067, KAKENHI-PROJECT-26670486
[Journal Article] The Role of Cas-L/NEDD9 as a Regulator of Collagen-induced Arthritis in a Murine Model2015
- Author(s)
  Tomoki Katayose, Satoshi Iwata, Naoki Oyaizu, Osamu Hosono, Taketo Yamada, Nam H Dang, Ryo Hatano, Hirotoshi Tanaka, Kei Ohnuma, Chikao Morimoto
- Journal Title
  
  Biochem Bilphys Res Commun
  
  Volume: 印刷中 Issue: 4 Pages: 1069-75
- DOI
  10.1016/j.bbrc.2015.03.156
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390236, KAKENHI-PROJECT-24591442, KAKENHI-PROJECT-15K15324, KAKENHI-PROJECT-26860760, KAKENHI-PROJECT-15H04879, KAKENHI-PROJECT-14J12067, KAKENHI-PROJECT-26670486
[Journal Article] CD26-mediated induction ofEGR2 and IL-10 as potential regulatory mechanism for CD26 costimulatory pathway2015
- Author(s)
  Hatano R, Ohnuma K, Otsuka H, Komiya E, Taki I, Iwata S, Dang NH, Okumura K, Morimoto C
- Journal Title
  
  J Immunol
  
  Volume: 16 Pages: 791-792
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670486
[Journal Article] Comparison of Two Commercial ELISAs against an In-House ELISA for Measuring Soluble CD26 in Human Serum.2015
- Author(s)
  Ohnuma K, Saito T, Hatano R, Hosono O, Iwata S, Dang NH, Ninomiya H, Morimoto C.
- Journal Title
  
  J Clin Lab Anal.
  
  Volume: Vol 29 Issue: 2 Pages: 106-11
- DOI
  10.1002/jcla.21736
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J12067, KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-23591434, KAKENHI-PROJECT-24591442, KAKENHI-PROJECT-24659401, KAKENHI-PROJECT-26670486, KAKENHI-PROJECT-26860760
[Journal Article] Regulation of Pulmonary Graft-versus-Host Disease by IL-26+CD26+CD4 T Lymphocytes.2015
- Author(s)
  Ohnuma K, Hatano R, Aune TM, Otsuka H, Iwata S, Dang NH, Yamada T, Morimoto C.
- Journal Title
  
  J Immunol
  
  Volume: 194(8) Issue: 8 Pages: 3697-712
- DOI
  10.4049/jimmunol.1402785
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591442, KAKENHI-PROJECT-15K15324, KAKENHI-PROJECT-26860760, KAKENHI-PROJECT-15H04879, KAKENHI-PROJECT-14J12067
[Journal Article] Comparison of two commercial ELISAs against an in-house ELISA for measuring soluble CD26 in human serum2015
- Author(s)
  Ohnuma K, Saito T, Hatano R, Hosono O, Iwata S, Dang NH, Ninomiya H, Morimoto C
- Journal Title
  
  J Clin Lab Anal
  
  Volume: Mar29 Pages: 106-111
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670486
[Journal Article] Regulation of pulmonary GVHD by IL-26+CD4 T lymphocytes through CD26/caveolin-1 interaction2015
- Author(s)
  Ohnuma K, Hatano R, Aune TM, Otsuka H, Iwata S, Dang NH, Yamada T, Morimoto C
- Journal Title
  
  J.Immunol
  
  Volume: 194(8) Pages: 3697-712
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670486
[Journal Article] Regulation of pulmonary GVHD by IL-26+CD4 T lymphocytes through CD26/caveolin-1 interaction2015
- Author(s)
  Ohnuma K, Hatano R, Aune TM, Otsuka H, Iwata S, Dang NH, Yamada T, Morimoto C
- Journal Title
  
  J Immunol.
  
  Volume: 194 Pages: 3697-3712
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670486
[Journal Article] Modulation of immunological responses and amelioration of collagen-induced arthritis by the novel roxithromycin derivative 5-I.2015
- Author(s)
  Otsuki N, Iwata S, Yamada T, Hosono O, Dang NH, Hatano R, Ohnuma K, Morimoto C.
- Journal Title
  
  Modern Rheumatology
  
  Volume: 25 Pages: 562-570
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15324
[Journal Article] CD26-mediated regulation of periostin expression contributes to migration and invasion of malignant pleural mesothelioma cells2014
- Author(s)
  Komiya E, Ohnuma K,Yamazaki H, Hatano R, Iwata S, Okamoto T, Dang NH, Yamada T, Morimoto C
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 4 Pages: 609-15
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670486
[Journal Article] Establishment of monoclonal anti-human CD26 antibodies suitable for immunostaining of formalin- fixed tissue2014
- Author(s)
  Hatano R, Yamada T, Matsuoka S, Iwata S, Yamazaki H, Komiya E, Okamoto T, Dang NH, Ohnuma K, Morimoto C
- Journal Title
  
  Diagn Pathol
  
  Volume: 9 Issue: 1 Pages: 30-30
- DOI
  10.1186/1746-1596-9-30
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-23390086, KAKENHI-PROJECT-24591442, KAKENHI-PROJECT-24659401, KAKENHI-PROJECT-25670195, KAKENHI-PROJECT-26670486
[Journal Article] CD9 Negatively Regulates CD26 Expression and Inhibits CD26-Mediated Enhancement of Invasive Potential of Malignant Mesothelioma cells2014
- Author(s)
  Okamoto T, Iwata S, Yamazaki H, Hatano R, Komiya E, Dang NH, Ohnuma K, Morimoto C.
- Journal Title
  
  PLoS One
  
  Volume: 9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670486
[Journal Article] Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma.2014
- Author(s)
  Yamamoto J, Ohnuma K, Hatano R, Okamoto T, Komiya E, Yamazaki H, Iwata S, Dang NH, Aoe K, Kishimoto T, Yamada T, Morimoto C.
- Journal Title
  
  Br J Cancer.
  
  Volume: Vol 110 Issue: 9 Pages: 2232-45
- DOI
  10.1038/bjc.2014.151
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J12067, KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-24591442, KAKENHI-PROJECT-24659401, KAKENHI-PROJECT-26670486, KAKENHI-PROJECT-26860760
[Journal Article] Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation.2014
- Author(s)
  Kwan JC, Liu Y, Ratnayake R, Hatano R, Kuribara A, Morimoto C, Ohnuma K, Paul VJ, Ye T, Luesch H.
- Journal Title
  
  Chembiochem.
  
  Volume: Vol 15 Issue: 6 Pages: 799-804
- DOI
  10.1002/cbic.201300762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J12067, KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-24659401, KAKENHI-PROJECT-26670486, KAKENHI-PROJECT-26860760
[Journal Article] Clinical significance of soluble CD26 in malignant pleural mesothelioma2014
- Author(s)
  Fujimoto N, Ohnuma K, Aoe K, Hosono O, Yamada T, Kishimoto T, Morimoto C
- Journal Title
  
  PLoS One
  
  Volume: Dec 19 Pages: 9-12
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670486
[Journal Article] CD26 Expression on T-anaplastic large cell lymphoma (ALCL) line Karpas 299 is associated with increased expression of versican and MT1-MMP and enhanced adhesion2013
- Author(s)
  Havre P, Ohnuma K, Iwata S, Morimoto C, Dang NH.
- Journal Title
  
  BMC Cancer
  
  Volume: 5 Issue: 1 Pages: 517-517
- DOI
  10.1186/1471-2407-13-517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-24591442, KAKENHI-PROJECT-24659401
[Journal Article] CD9 negatively regulates CD26 expression and inhibits CD26-mediated enhancement of invasive potential of malignant mesothelioma cells2013
- Author(s)
  Okamoto T, Iwata S, Yamazaki H, Hatano R, Komiya E, Dang NH, Ohnuma K, Morimoto C
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 1 Pages: e86671-e86671
- DOI
  10.1371/journal.pone.0086671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-24591442, KAKENHI-PROJECT-24659401
[Journal Article] Inhibition of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection by Anti-CD26 Monoclonal Antibody2013
- Author(s)
  Ohnuma K, Haagman BL, Hatano R, Raj VS, Mou H, Iwata S, Dang NH, Bosch BJ, Morimoto C
- Journal Title
  
  J Virology
  
  Volume: 87 Issue: 24 Pages: 13892-13899
- DOI
  10.1128/jvi.02448-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-24591442, KAKENHI-PROJECT-24659401
[Journal Article] Nuclear localization of CD26 induced by a humanized monoclonal antibody inhibits tumor cell growth by modulating of POLR2A transcription2013
- Author(s)
  Yamada K, Hayashi M, Madokoro H, Nishida H, Du W, Ohnuma K, Sakamoto M, Morimoto C, Yamada T
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 4 Pages: e62304-e62304
- DOI
  10.1371/journal.pone.0062304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-24659401, KAKENHI-PROJECT-25430157, KAKENHI-PROJECT-25670195
[Journal Article] Polyarthropathy in type 2 diabetes patients treated with DPP4 inhibitors2013
- Author(s)
  Saito T, Ohnuma K, Dang NH, Hatano R, Ninomiya H, Morimoto C
- Journal Title
  
  Diabetes Res Clin Pract
  
  Volume: 102 Issue: 1 Pages: e8-e12
- DOI
  10.1016/j.diabres.2013.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-24659401
[Journal Article] Prevention of acute graft-versus-host disease by humanized anti-CD26 monoclonal antibody2013
- Author(s)
  Hatano R, Ohnuma K, Yamamoto J, Dang NH, Yamada T, Morimoto C
- Journal Title
  
  Br J Haematol
  
  Volume: 162 Issue: 2 Pages: 263-77
- DOI
  10.1111/bjh.12378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-23390086, KAKENHI-PROJECT-24659401, KAKENHI-PROJECT-25670195
[Journal Article] DPP4 (dipeptidyl-peptidase 4)2013
- Author(s)
  Ohnuma K, Morimoto C
- Journal Title
  
  Atlas of Genetics and Cytogenetics in Oncology and Hematology
  
  Volume: 17 Issue: 5 Pages: 301-312
- DOI
  10.4267/2042/49697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] CD26-mediated co-stimulation in human CD8^+ T cells provokes effector function via pro-inflammatory cytokine production2013
- Author(s)
  Hatano R, Ohnuma K, Yamamoto J, Dang NH, Morimoto C
- Journal Title
  
  Immunology
  
  Volume: 138 Issue: 2 Pages: 165-172
- DOI
  10.1111/imm.12028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-22390200, KAKENHI-PROJECT-24659401
[Journal Article] Effect of renal impairment on the pharmacokinetics of memantine2012
- Author(s)
  Ohnuma K et al
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 119 Pages: 324-9
- NAID
  10031071476
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/22863669.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] CD26 and its signaling pathway2012
- Author(s)
  Ohnuma K
- Journal Title
  
  Nihon Rinsho.
  
  Volume: 70 Pages: 176-180
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] CD26 Overexpression is associated with prolonged survival and enhanced chemosensitivity in malignant pleural mesothelioma2012
- Author(s)
  Aoe K, Amatya VJ, Fujimoto N, Ohnuma K, Hosono O, Hiraki A, Fujii M, Yamada T, Dang NH, Takeshima Y, Inai K, Kishimoto T, Morimoto C
- Journal Title
  
  Clin Cancer Res
  
  Volume: 18(5) Issue: 5 Pages: 1447-1456
- DOI
  10.1158/1078-0432.ccr-11-1990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-22390200, KAKENHI-PROJECT-22650223, KAKENHI-PROJECT-23591434
[Journal Article] Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice.2011
- Author(s)
  Shirakawa J, Ohnuma K, et, al.
- Journal Title
  
  Diabetes
  
  Volume: 60 Pages: 1246-1257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] Dipeptidyl peptidase in autoimmune pathophysiology2011
- Author(s)
  Ohnuma K, Hosono O, et al.
- Journal Title
  
  Advances in Clinical Chemistry
  
  Volume: 53 Pages: 51-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] Mechanisms of confluence-dependent expression of CD26 in colon cancer cell lines.2011
- Author(s)
  Abe, M, Ohnuma K, et. al.
- Journal Title
  
  BMC Cancer
  
  Volume: 11 Pages: 51-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] Mechanisms of confluence-dependent expression of CD26 in colon cancer cell lines2011
- Author(s)
  Abe M, Havre PA, Urasaki Y, Ohnuma K, Morimoto C, Dang LH, Dang NH
- Journal Title
  
  BMC Cancer
  
  Volume: 11 Issue: 1 Pages: 51-51
- DOI
  10.1186/1471-2407-11-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-22390200, KAKENHI-PROJECT-22650223
[Journal Article] Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice2011
- Author(s)
  Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K, Aoki K, Morimoto C, Takeda E, Terauchi Y
- Journal Title
  
  Diabetes
  
  Volume: 60(4) Issue: 4 Pages: 246-1257
- DOI
  10.2337/db10-1338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J03269, KAKENHI-PROJECT-21300277, KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-22390200, KAKENHI-PROJECT-22590437, KAKENHI-PROJECT-22650223, KAKENHI-PROJECT-23591315
[Journal Article] Microscopic polyangiitis initiated with liver dysfunction, calf pain and fever of unknown origin.2010
- Author(s)
  Ohnuma K, Hosono O, Katayose T, Yoshikawa N, Kawasaki H, Fujii T, Oyaizu N, Tanaka H, Morimoto C
- Journal Title
  
  Rheumatol Int. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Inhibition of dipeptidyl peptidase 4 regulates microvascular endothelial growth induced by inflammatory cytokines.2010
- Author(s)
  Takasawa W, Ohnuma K, et. al.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 401 Pages: 7-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] Inhibition of dipeptidyl peptidase 4 regulates micro-vascular endothelial growth induced by inflammatory cytokines2010
- Author(s)
  Takasawa W, Ohnuma K, Hatano R, Endo Y, Dang NH, Morimoto C
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 40 Issue: 1 Pages: 7-12
- DOI
  10.1016/j.bbrc.2010.08.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-22390200, KAKENHI-PROJECT-22650223
[Journal Article] Microscopic polyangiitis initiated with liver dysfunction, calf pain and fever of unknown origin2010
- Author(s)
  Ohnuma K, Hosono O, Katayose T, Yoshikawa N, Kawasaki H, Fujii T, Oyaizu N, Tanaka H, Morimoto C
- Journal Title
  
  Rheumatol Int
  
  Volume: 30 Issue: 12 Pages: 1651-6
- DOI
  10.1007/s00296-009-1121-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] Localization of CD26/DPPIV in nucleus and its nuclear translocation enhanced by anti-CD26 monoclonal antibody with anti-tumor effect.2009
- Author(s)
  Yamada K, Hayashi M, Du W, Ohnuma K, Sakamoto M, Morimoto C, Yamada T.
- Journal Title
  
  Cancer Cell Int. 9
  
  Pages: 17-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Histamine H1-receptor antagonists with immunomodulating activities : potential use for modulating T helper type 1 (Th1)/Th2 cytokine imbalance and inflammatory responses in allergic diseases.2009
- Author(s)
  Okamoto T, Iwata S, Ohnuma K, Dang NH, Morimoto C
- Journal Title
  
  Clin Exp Immunol. 157
  
  Pages: 27-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] CD26 expression on T cell lines increases SDF-1α-mediated invasion2009
- Author(s)
  Havre PA, Abe M, Urasaki Y, Ohnuma K, Morimoto C, Dang NH
- Journal Title
  
  Br J Cancer
  
  Volume: 101 Issue: 6 Pages: 983-991
- DOI
  10.1038/sj.bjc.6605236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] An adult case of Henoch-Schonlein purpura complicating common peroneal nerve mononeuropathy.2009
- Author(s)
  Ohnuma K, Hosono O, Kawasaki H, Yoshikawa N, Katayose T, Oyaizu N, Tanaka H, Morimoto C
- Journal Title
  
  Mod Rheumatol. 19
  
  Pages: 73-79
- NAID
  10025112125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Microscopic polyangiitis initiated with liver dysfunction, calf pain and fever of unknown origin.2009
- Author(s)
  Ohnuma K, et al.
- Journal Title
  
  Rheumatology International Sep 23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] An adult case of Henoch-Schonlein purpura complicating common peroneal nerve mononeuropathy.2009
- Author(s)
  Ohnuma K, et al.
- Journal Title
  
  Modern Rheumatology 19
  
  Pages: 73-79
- NAID
  10025112125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] An adult case of Henoch?SchOnlein purpura complicating common peroneal nerve mononeuropathy.2009
- Author(s)
  Ohnuma K, Hosono O, et al.
- Journal Title
  
  Modern Rheumatology 19
  
  Pages: 73-79
- NAID
  10025112125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] Localization of CD26/DPPIV in nucleus and its nuclear translocation enhanced by anti-CD26 monoclonal antibody with antitumor effect.2009
- Author(s)
  Yamada K, Ohnuma K, et al.
- Journal Title
  
  Cancer Cell International 9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] Histamine H1-receptor anta- gonists with immunomodulating activities : potential use for modulating T helper type 1 (Th1)/Th2 cytokine imbalance and inflammatory responses in allergic diseases2009
- Author(s)
  Okamoto T, Iwata S, Ohnuma K, Dang NH, Morimoto C
- Journal Title
  
  Clin Exp Immunol
  
  Volume: 157 Issue: 1 Pages: 27-34
- DOI
  10.1111/j.1365-2249.2009.03958.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] Localization of CD26/DPPIV in nucleus and its nuclear translocation enhanced by anti-CD26 monoclonal antibody with anti-tumor effect2009
- Author(s)
  Yamada K, Hayashi M, Du W, Ohnuma K, Sakamoto M, Morimoto C, Yamada T
- Journal Title
  
  Cancer Cell Int
  
  Volume: 9 Issue: 1 Pages: 17-17
- DOI
  10.1186/1475-2867-9-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] An adult case ofHenoch-Schonlein2009
- Author(s)
  Ohnuma K, Hosono O, Kawasaki H,Yoshikawa N, Katayose T, Oyaizu N, TanakaH, Morimoto C.
- Journal Title
  
  purpura complicatingcommon peroneal nerve mononeuropathy.Modern Rheumatology 19
  
  Pages: 73-79
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] CD26 expression on T cell lines increases SDF-1-alpha-mediated invasion.2009
- Author(s)
  Havre PA, Abe M, Urasaki Y, Ohnuma K, Morimoto C, Dang NH
- Journal Title
  
  Br J Cancer. 101
  
  Pages: 983-991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] An adult case of Henoch-Schonlein purpura complicating common peroneal nerve mononeuropathy2009
- Author(s)
  Ohnuma K, Hosono O, Kawasaki H, Yoshikawa N, Katayose T, Oyaizu N, Tanaka H, Morimoto C.
- Journal Title
  
  Mod Rheumatol. 19
  
  Pages: 73-9
- NAID
  10025112125
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] CD26 expression on T cell lines increases SDF-1α-mediated invasion.2009
- Author(s)
  Harve PA, Ohnuma K, et al.
- Journal Title
  
  British Journal of Cancer 101
  
  Pages: 983-991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] Histamine H1-receptor antagonists with immunomodulating activities : potential use for modulating Th1/Th2 cytokine imbalance and inflammatory responses in allergic diseases.2009
- Author(s)
  Okamoto T, Ohnuma K, et al
- Journal Title
  
  Clinical and Experimental Immunology 157
  
  Pages: 27-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] Histamine Hl-receptor antagonists with immunomodulating activities : potential use for modulating T helper type 1 (Th1)/Th2 cytokine imbalance and inflammatory responses in allergic diseases2009
- Author(s)
  Okamoto T, Iwata S, Ohnuma K, Dang NH, Morimoto C.
- Journal Title
  
  Clin Exp Immunol. 157
  
  Pages: 27-34
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Localization of CD26/DPPIV in nucleus and its nuclear translocation enhanced by anti-CD26 monoclonal antibody with anti-tumor effect2009
- Author(s)
  Yamada K, Hayashi M, Du W, Ohnuma K, Sakamoto M, Morimoto C, Yamada T.
- Journal Title
  
  Cancer Cell Int.
  
  Pages: 9-17
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Microscopic polyangiitis initiated with liver dysfunction, calf pain and fever of unknown origin2009
- Author(s)
  Ohnuma K, Hosono O, Katayose T, Yoshikawa N, Kawasaki H, Fujii T, Oyaizu N, Tanaka H, Morimoto C.
- Journal Title
  
  Rheumatol Int.
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4 (+) T cells2009
- Author(s)
  Ohnuma K, Uchiyama M, Hatano R, Takasawa W, Endo Y, Dang NH, Morimoto C.
- Journal Title
  
  Biochem Biophys Res Commun. 386
  
  Pages: 327-32
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] CD26 expression on T cell lines increases SDF-1-alpha-mediated invasion2009
- Author(s)
  Havre PA, Abe M, Urasaki Y, Ohnuma K, Morimoto C, Dang NH.
- Journal Title
  
  Br J Cancer. 101
  
  Pages: 983-91
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4+T cells.2009
- Author(s)
  Ohnuma K, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 386
  
  Pages: 327-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4(+)T cells.2009
- Author(s)
  Ohnuma K, Uchiyama M, Hatano R, Takasawa W, Endo Y, Dang NH, Morimoto C
- Journal Title
  
  Biochem Biophys Res Commun. 386
  
  Pages: 327-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4^+ T cells2009
- Author(s)
  Ohnuma K, Uchiyama M, Hatano R, Takasawa W, Endo Y, Dang NH, Morimoto C
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 386 Issue: 2 Pages: 327-332
- DOI
  10.1016/j.bbrc.2009.06.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005
[Journal Article] The role of CD26/dipeptidyl peptidase IV in cancer2008
- Author(s)
  Harve PA, Ohnuma K, et. al.
- Journal Title
  
  Frontiers in Biosciences 13
  
  Pages: 2299-2310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] Comparative studyof regulatory T cell function of humanCD25+CD4+ T cells from thymocytes, cordblood, and adult peripheral blood2008
- Author(s)
  Fujimaki W, Takahasi N, Ohnuma K, Nagatsu M, Kurosawa H, Yoshida S, Dang NH,Uchiyama T, Morimoto C.
- Journal Title
  
  Clinical and Developmental Immunology 2008
  
  Pages: 205859-205859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] SSA/Ro52 autoantigen interacts with Dcp2 to enhance2008
- Author(s)
  Yamochi T, Ohnuma K, Hosono O, TanakaH, Kanai Y, Morimoto C.
- Journal Title
  
  its decapping activity. Biochem Biophys Res Commun 370(1)
  
  Pages: 195-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity2008
- Author(s)
  Yamochi T, Ohnuma K, Hosono O, Tanaka H, Kanai Y, Morimoto C.
- Journal Title
  
  Biochem Biophys Res Commun. 370
  
  Pages: 195-9
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Role of the hinge region of glucocorticoid receptor for HEXIM1-mediated transcriptional repression2008
- Author(s)
  Yoshikawa N, Shimizu N, Sano M, Ohnuma K, Iwata S, Hosono O, Fukuda K, Morimoto C, Tanaka H.
- Journal Title
  
  Biochem Biophys Res Commun. 371
  
  Pages: 44-9
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Comparative study of regulatory T cell function of human CD25+CD4+ T cells from thymocytes, cord blood, and adult peripheral blood.2008
- Author(s)
  Fujimaki W, Ohnuma K, et al.
- Journal Title
  
  Clinical and Developmental Immunology 2008
  
  Pages: 305859-305859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] The role of CD26/dipeptidyl peptidase IV in cancer2008
- Author(s)
  Havre PA, Abe M, Urasaki Y, Ohnuma K, Morimoto C, Dang NH.
- Journal Title
  
  Front Biosci. 13
  
  Pages: 1634-45
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] The role of CD26/dipeptidyl peptidase IV in cancer2008
- Author(s)
  Harve PA, Abe M, Urasaki Y, Ohnuma K, Morimoto C, Dang NH.
- Journal Title
  
  Frontiers in Biosciences 13
  
  Pages: 1634-1645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] Revisiting an old acquaintance : CD26 and its2008
- Author(s)
  Ohnuma K, Dang NH, Morimoto C.
- Journal Title
  
  molecular mechanisms in T cell function. Trends in Immunology 29
  
  Pages: 295-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] Role of CD26/dipeptidyl peptidase IV in human T2008
- Author(s)
  Ohnuma K, Takahashi N, Yamochi T,Hosono O, Dang NH, Morimoto C.
- Journal Title
  
  cell activation and function. Frontiers inBiosciences 13
  
  Pages: 2299-2310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] Role of CD26/dipeptidyl peptidase IV in human T cell activation and function2008
- Author(s)
  Ohnuma K, Takahashi N, Yamochi T, Hosono O, Dang NH, Morimoto C.
- Journal Title
  
  Front Biosci. 13
  
  Pages: 2299-310
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function.2008
- Author(s)
  Ohnuma K, Dang NH, et al.
- Journal Title
  
  Trends in Immunology 29
  
  Pages: 295-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood2008
- Author(s)
  Fujimaki W, Takahashi N, Ohnuma K, Nagatsu M, Kurosawa H, Yoshida S, Dang NH, Uchiyama T, Morimoto C.
- Journal Title
  
  Clin Dev Immunol. 2008
  
  Pages: 305859-305859
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Role of CD26/dipeptidyl peptidase IV in human T cell activation and function.2008
- Author(s)
  Ohnuma K, Takahashi N, et. al.
- Journal Title
  
  Frontiers in Biosciences 13
  
  Pages: 2299-2310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] Role of CD26/dipeptidyl peptidase IV in human T cell activation and function2008
- Author(s)
  Ohnuma K, Hosono O, Dang NH, Morimoto C, et. al.
- Journal Title
  
  Front Biosci 13
  
  Pages: 2299-2310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Revisiting an old acquaintance : CD26 and its molecular mechanisms in T cell function2008
- Author(s)
  Ohnuma K, Dang NH, Morimoto C.
- Journal Title
  
  Trends Immunol. 29
  
  Pages: 295-301
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Humanized anti-CD26 monoclonal antibody as a treatment for malignant2007
- Author(s)
  Inamoto T, Yamada T, Ohnuma K, Kina S,Takahashi N, Yamochi T, Inamoto S, KatsuokaY, Hosono O, Tanaka H, Dang NH, and Morimoto C.
- Journal Title
  
  mesothelioma tumors. Clinical Cancer Research 13
  
  Pages: 4191-4200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] Caveolin-1 triggers T-cell activation via CD26 in association with CARMA12007
- Author(s)
  Ohnuma K, Uchiyama M, Yamochi T, Nishibashi K, Hosono O, Takahashi N, Kina S, Tanaka H, Lin X, Dang NH, Morimoto C.
- Journal Title
  
  J Biol Chem. 282
  
  Pages: 10117-31
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Humanized Anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors2007
- Author(s)
  Inamoto T, Yamada T, Ohnuma K, Kina S, Takahashi N, Yamochi T, Inamoto S, Katsuoka Y, Hosono O, Tanaka H, Dang NH, Morimoto C.
- Journal Title
  
  Clin Cancer Res. 13
  
  Pages: 4191-200
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] CD26/Dipeptidyl Peptidase IV as a Novel Therapeutic Target for Cancer and Immune Disorders.2007
- Author(s)
  Thompson MA, Ohnuma, K, Abe M, et al.
- Journal Title
  
  Medicinal Chemistry 7(3)
  
  Pages: 253-273
- Data Source
  KAKENHI-PROJECT-17689032
[Journal Article] Knockdown of XAB2 enhances all-trans retionic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells2007
- Author(s)
  Ohnuma-Ishikawa K, Morimoto C, et al.
- Journal Title
  
  Cancer Res. 67
  
  Pages: 1019-29
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Caveolin-1 triggers T-cell activation via CD26 in association with CARMA12007
- Author(s)
  Kei Ohnuma
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 10117-31
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591100
[Journal Article] Caveolin-1 triggers T-cell activation via2007
- Author(s)
  Ohnuma K, Uchiyama M, Yamochi T, Nishibashi K, Hosono O, Takahashi N, Kina S, Tanaka H, Lin X, Dang NH, Morimoto C.
- Journal Title
  
  CD26 in association with CARMA1. J BiolChem 282(13)
  
  Pages: 10117-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] Humanized anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors2007
- Author(s)
  Inamoto T, Ohnuma K, et. al.
- Journal Title
  
  Clinical Cancer Research 13
  
  Pages: 4191-4200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells2007
- Author(s)
  Ohnuma-Ishikawa K, Morio T, Yamada T, Sugawara Y, Ono M, Nagasawa M, Yasuda A, Morimoto C, Ohnuma K, Dang NH, Hosoi H, Verdin E, Mizutani S.
- Journal Title
  
  Cancer Res. 67
  
  Pages: 1019-29
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Caveolin-1 triggers T-cell activation via CD26 in association with CARMAl2007
- Author(s)
  Ohnuma K, Morimoto C, et al.
- Journal Title
  
  J Biol Chem. 282
  
  Pages: 10117-31
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.2007
- Author(s)
  大沼圭、
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 10117-31
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591100
[Journal Article] Caveolin-1 tiggers T-cell activation via CD26 in association with CARAMA1.2007
- Author(s)
  大沼圭
- Journal Title
  
  Journal of Biological Chemistry 282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591100
[Journal Article] Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans2007
- Author(s)
  Ohnuma-Ishikawa K, Morio T, Yamada T, Sugawara Y, Ono M, Nagasawa M, Yasuda A, Morimoto C, Ohnuma K, Dang NH, Hosoi H, Verdin E, Mizutani S.
- Journal Title
  
  retinoic acid-sensitive and -resistant cancer cells. Cancer Res 67(3)
  
  Pages: 1019-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591240
[Journal Article] Anti-CD26 monoclonal antibody-mediated G1-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27 (kipl) enhancement, and disruption of binding to the extracellular matrix2006
- Author(s)
  Inamoto T, Yamochi T, Ohnuma K, Iwata S, Kina S, Inamoto S, Tachibana M, Katsuoka Y, Dang NH, Morimoto C.
- Journal Title
  
  Clin Cancer Res. 12
  
  Pages: 3470-7
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] T-cell activation via CD26 and caveolin-1 in rheumatoid synovium.2006
- Author(s)
  大沼圭
- Journal Title
  
  Modern Rheumatology 16・1
  
  Pages: 3-3
- NAID
  10017351703
- Data Source
  KAKENHI-PROJECT-18591100
[Journal Article] T-cell activation via CD26 and caveolin-1 in rheumatoid synovium.2006
- Author(s)
  Ohnuma K, Inoue H, Uchiyama M, et al.
- Journal Title
  
  Modern Rheumatology 16(1)
  
  Pages: 3-13
- NAID
  10017351703
- Data Source
  KAKENHI-PROJECT-17689032
[Journal Article] Anti-CD26 monoclonal antibody-mediated Gl-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27(kip1) enhancement, and disruption of binding to the extracellular matrix.2006
- Author(s)
  Inamoto T, Yamochi T, Ohnuma K, et al.
- Journal Title
  
  Clinical Cancer Research 12(11)
  
  Pages: 3470-3477
- Data Source
  KAKENHI-PROJECT-17689032
[Journal Article] CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells2005
- Author(s)
  Ohnuma K, Yamochi T, Uchiyama M, Nishibashi K, Iwata S, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
- Journal Title
  
  Mol Cell Biol. 25
  
  Pages: 7743-57
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] TCR engagement increases hypoxia-inducible factor-1 alpha protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells.2005
- Author(s)
  Nakamura H, Makino Y, Ohnuma K, et al.
- Journal Title
  
  Journal of Immunology 174(12)
  
  Pages: 7592-7599
- Data Source
  KAKENHI-PROJECT-17689032
[Journal Article] CD26 regulates p38 mitogen-activated protein kinase-dependent phosphorylation of integrin betal, adhesion to extracellular matrix, and tumorigenicity of T-anaplastic large cell lymphoma Karpas 2992005
- Author(s)
  Sato T, Yamochi T, Yamochi T, Aytac, Ohnuma K, McKee KS, Morimoto C, Dang NH.
- Journal Title
  
  Cancer Res. 65
  
  Pages: 6950-6
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Regulation of p38 phosphorylation and topoisomerase IIalpha expression in the B-cell lymphoma line Jiyoye by CD26/dipeptidyl peptidase IV is associated with enhanced in vitro and in vivo sensitivity to doxorubicin.2005
- Author(s)
  Yamochi T, Yamochi T, Ohnuma K, et al.
- Journal Title
  
  Cancer Research 65(5)
  
  Pages: 1973-1983
- Data Source
  KAKENHI-PROJECT-17689032
[Journal Article] CD26 T cells in the pathogenesis of asthma.2005
- Author(s)
  Ohnuma K, Yamochi T, Hosono O, Morimoto C.
- Journal Title
  
  Clin Exp Immunol. 139
  
  Pages: 13-16
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] CD26 T cells in the pathogenesis of asthma2005
- Author(s)
  Ohnuma K, Yamochi T, Hosono O, Morimoto C.
- Journal Title
  
  Clin Exp Immunol. 139
  
  Pages: 13-16
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells.2005
- Author(s)
  Ohnuma K, Yamochi T, Uchiyama M, et al.
- Journal Title
  
  Molecular and Cellular Biology 25(17)
  
  Pages: 7743-7757
- Data Source
  KAKENHI-PROJECT-17689032
[Journal Article] CD26 regulates p38 mitogen-activated protein kinase-dependent phosphorylation of integrin bete1, adhesion to extracellular matrix, and tumorigenicity of T-anaplastic large cell lymphoma Karpas 299.2005
- Author(s)
  Sato T, Yamochi T, Ohnuma K, et al.
- Journal Title
  
  Cancer Reseach 65(15)
  
  Pages: 6950-6956
- Data Source
  KAKENHI-PROJECT-17689032
[Journal Article] CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells.2005
- Author(s)
  Ohnuma K, Morimoto C, et al.
- Journal Title
  
  Mol Cell Biol. 25
  
  Pages: 7743-7757
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] CD26+T cells in the pathogenesis of asthma.2005
- Author(s)
  Ohnuma K, Yamochi T, Hosono O, et al.
- Journal Title
  
  Clinical and Experimental Immunology 139(1)
  
  Pages: 13-16
- Data Source
  KAKENHI-PROJECT-17689032
[Journal Article] Regulation of p38 phosphorylation and topoisomerase IIalpha expression in the B-cell lymphoma line Jiyoye by CD26/dipeptidyl peptidase IV is associated with enhanced in vitro and in vivo sensitivity to doxorubicin2005
- Author(s)
  Yamochi T, Yamochi T, Aytac U, Sato T, Sato K, Ohnuma K, McKee KS, Morimoto C, Dang NH.
- Journal Title
  
  Cancer Res. 65
  
  Pages: 1973-83
- Data Source
  KAKENHI-PROJECT-17109011
[Patent] 抗CD26抗体と免疫チェックポイント阻害剤との併用療法2022
- Inventor(s)
  森本幾夫, 波多野良, 大沼圭, 金子有太郎
- Industrial Property Rights Holder
  ワイズ・エー・シー株式会社, 学校法人順天堂
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20H03471
[Patent] 抗CD26抗体と免疫チェックポイント阻害剤との併用療法.2021
- Inventor(s)
  森本幾夫、波多野良、大沼圭、金子有太郎.
- Industrial Property Rights Holder
  ワイズ・エー・シー株式会社、学校法人順天堂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-091761
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20H03471
[Patent] 抗癌剤への抵抗性改善剤.2021
- Inventor(s)
  森本幾夫、大沼圭、波多野良、伊藤匠、金子有太郎.
- Industrial Property Rights Holder
  ワイズ・エー・シー株式会社、学校法人順天堂
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20H03471
[Patent] 抗癌剤への抵抗性改善剤2020
- Inventor(s)
  森本幾夫、大沼圭、波多野良、伊藤匠、金子有太郎
- Industrial Property Rights Holder
  ワイズ・エー・シー株式会社、学校法人順天堂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-099449
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20H03471
[Patent] 抗癌剤への抵抗性改善剤2020
- Inventor(s)
  森本幾夫、大沼圭、伊藤匠、波多野良、金子有太郎
- Industrial Property Rights Holder
  ワイズ・エー・シー株式会社、学校法人順天堂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-099449
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02782
[Patent] 免疫チェックポイント阻害剤2019
- Inventor(s)
  大沼圭、森本幾夫、波多野良
- Industrial Property Rights Holder
  大沼圭、森本幾夫、波多野良
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-004480
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18H02782
[Patent] 免疫チェックポイント阻害剤2019
- Inventor(s)
  大沼圭、森本幾夫、波多野良
- Industrial Property Rights Holder
  学校法人順天堂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-004480
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16H05345
[Patent] 抗ヒトCD26モノクローナル抗体2018
- Inventor(s)
  森本幾夫、波多野良、山田健人、大沼圭
- Industrial Property Rights Holder
  学校法人順天堂，学校法人埼玉医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-049308
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16H05345
[Patent] 抗ヒトIL-26抗体2017
- Inventor(s)
  森本幾夫、波多野良、大沼圭、伊藤匠
- Industrial Property Rights Holder
  学校法人順天堂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-231439
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15H04879
[Patent] 抗ヒトIL-26抗体2017
- Inventor(s)
  森本幾夫、波多野良、大沼圭、伊藤匠
- Industrial Property Rights Holder
  学校法人順天堂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-231439
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16H05345
[Patent] 免疫抑制剤2014
- Inventor(s)
  森本幾夫、大沼圭、波多野良
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Filing Date
  2014-09-29
- Data Source
  KAKENHI-PROJECT-26670486
[Patent] 抗ヒトCD26モノクローナル抗体又はその抗原結合性断片2013
- Inventor(s)
  大沼圭、波多野良、山田健人、森本幾夫
- Industrial Property Rights Holder
  順天堂大学、キッセイ薬品工業
- Industrial Property Rights Type
  特許
- Filing Date
  2013-07-31
- Data Source
  KAKENHI-PROJECT-21679005
[Patent] MERSコロナウイルス感染症予防治療剤2013
- Inventor(s)
  大沼圭、森本幾夫
- Industrial Property Rights Holder
  順天堂大学
- Filing Date
  2013-09-17
- Data Source
  KAKENHI-PROJECT-21679005
[Patent] MERSコロナウイルス感染症予防治療剤2013
- Inventor(s)
  大沼圭、森本幾夫
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-09-17
- Data Source
  KAKENHI-PROJECT-21679005
[Patent] 抗ヒトCD26モノクローナル抗体又はその抗原結合性断片2013
- Inventor(s)
  大沼圭、波多野良、山田健人、森本幾夫
- Industrial Property Rights Holder
  順天堂大学、キッセイ薬品工業
- Filing Date
  2013-07-31
- Data Source
  KAKENHI-PROJECT-21679005
[Patent] 細胞表面分子CD26を標的とした悪性中皮腫の治療法2007
- Inventor(s)
  森本幾夫, 大沼圭, 稲元輝生
- Industrial Property Rights Holder
  国立大学法人東京大学
- Filing Date
  2007-03-14
- Data Source
  KAKENHI-PROJECT-17109011
[Patent] caveolin-1-Fcγ 1融合タンパク質及びその使用2006
- Inventor(s)
  森本幾夫, 大沼圭
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2006-351154
- Filing Date
  2006-12-27
- Data Source
  KAKENHI-PROJECT-17109011
[Patent] 免疫調整剤のスクリーニング方法2006
- Inventor(s)
  森本幾夫, 大沼圭
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2006-351173
- Filing Date
  2006-12-17
- Data Source
  KAKENHI-PROJECT-17109011
[Patent] caveolin-1-Fc γ1融合タンパク質及びその使用2006
- Inventor(s)
  森本幾夫, 大沼圭
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2006-351154
- Filing Date
  2006-12-27
- Data Source
  KAKENHI-PROJECT-17109011
[Presentation] Functional Roles for CD26/DPP4 in LPS-induced Lung Injury in Mice.2023
- Author(s)
  Sato S, Kawasaki T, Hatano R, Koyanagi Y, Takahashi Y, Ohnuma K, Morimoto C, Dudek SM, Tatsumi K, Suzuki T.
- Organizer
  American Thoracic Society 2023 International Conference, Washington, DC, USA, 2023年5月19日
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27395
[Presentation] Functional Roles for CD26/DPP4 in Mouse Bleomycin-induced Pulmonary Fibrosis.2023
- Author(s)
  Koyanagi Y, Kawasaki T, Kasuya Y, Hatano R, Takahashi Y, Sato S, Ohnuma K, Morimoto C, Tatsumi K, Suzuki T.
- Organizer
  American Thoracic Society 2023 International Conference, Washington, DC, USA, 2023年5月19日
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27395
[Presentation] Mu-opioid ligand endomorphin induces alloknesis at the periphery.2021
- Author(s)
  Komiya E, Tominaga M, Hatano R, Itoh T, Honda K, Toyama S, Kamata Y, Otsuka H, Ohnuma K, Morimoto C, Takamori K.
- Organizer
  第46回日本研究皮膚科学会, 口頭発表, Web開催
- Data Source
  KAKENHI-PROJECT-20H03471
[Presentation] CD26/dipeptidyl-peptidase IVは機械的かゆみの調節因子である.2021
- Author(s)
  古宮栄利子, 冨永光俊, 波多野良, 外山扇雅, 伊藤匠, 鎌田弥生, 本田耕太郎, 大沼圭, 森本幾夫, 高森建二.
- Organizer
  第26回日本病態プロテアーゼ学会, 口頭発表, Web開催
- Data Source
  KAKENHI-PROJECT-20H03471
[Presentation] CD26/DPPIV regulates mechanical alloknesis at the periphery.2021
- Author(s)
  Komiya E, Tominaga M, Hatano R, Itoh T, Honda K, Toyama S, Kamata Y, Otsuka H, Ohnuma K, Morimoto C, Takamori K.
- Organizer
  11th World Congress on Itch (WCI), 口頭発表, Web開催
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03471
[Presentation] Anti-interleukin-26 therapy for the control of chronic inflammation in GVHD.2021
- Author(s)
  Hatano R, Otsuka H, Itoh T, Saeki H, Yamamoto A, Shirakawa Y, Iyama S, Iwao N, Sato T, Yamada T, Morimoto C, Ohnuma K.
- Organizer
  第83回日本血液学会, 口頭発表, Web開催
- Data Source
  KAKENHI-PROJECT-20H03471
[Presentation] 9.Endomorphin preferentially induces mechanical alloknesis under the control of DPPIV enzyme2020
- Author(s)
  Eriko Komiya, Ryo Hatano, Takumi Itoh, Kotaro Honda, Yayoi Kamata, Sumika Toyama, Catharina Sagita Moniaga, Haruna Otsuka, Nobuaki Takahashi, Kei Ohnuma, Mitsutoshi Tominaga, Chikao Morimoto, Kenji Takamori
- Organizer
  The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-18H02782
[Presentation] Endomorphin preferentially induces mechanical alloknesis under the control of DPPIV enzyme.2020
- Author(s)
  Eriko Komiya, Ryo Hatano, Takumi Itoh, Kotaro Honda, Yayoi Kamata, Sumika Toyama, Catharina Sagita Moniaga, Haruna Otsuka, Nobuaki Takahashi, Kei Ohnuma, Mitsutoshi Tominaga, Chikao Morimoto, Kenji Takamori.
- Organizer
  The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-20H03471
[Presentation] 加齢皮膚で誘発される機械的かゆみ調節機構の解明2019
- Author(s)
  古宮栄利子、冨永光俊、波多野良、伊藤匠、大塚春奈、本田耕太郎、外山扇雅、鎌田弥生、大沼圭、森本幾夫、髙森建二
- Organizer
  第15回加齢皮膚医学研究会
- Data Source
  KAKENHI-PROJECT-16H05345
[Presentation] CD26分子はDPPⅣ酵素活性によって乾癬のかゆみを調節する2018
- Author(s)
  古宮栄利子、波多野良、大塚春奈、伊藤匠、大沼圭、冨永光俊、森本幾夫、髙森建二
- Organizer
  第33回日本乾癬学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05345
[Presentation] 全身性エリテマトーデスのステロイド減量困難例におけるCD26陰性T細胞サブセットの増加について2018
- Author(s)
  波多野良、大沼圭、石井智徳、伊藤匠、岩田哲史、奥村康、関川巖、森本幾夫
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16H05345
[Presentation] 難治性自己免疫疾患における新規炎症性サイトカインIL-26の役割と分子標的療法の開発2018
- Author(s)
  伊藤匠、波多野良、岩田哲史、大沼圭、森本幾夫
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16H05345
[Presentation] 乾癬における新規炎症性サイトカインIL-26の役割と分子標的療法の開発2018
- Author(s)
  伊藤匠、波多野良、古宮栄利子、大塚春奈、冨永光俊、髙森建二、森本幾夫、大沼圭
- Organizer
  第33回日本乾癬学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05345
[Presentation] 急性GVHDマウスモデルにおけるHMGB1の動態に関する検討2018
- Author(s)
  岩尾憲明、大沼圭、大塚春奈、波多野良、古宮栄利子、伊藤匠、森本幾夫
- Organizer
  第40回日本造血細胞移植学会総会
- Data Source
  KAKENHI-PROJECT-16K09878
[Presentation] 難治性自己免疫疾患における新規炎症性サイトカインIL-26の役割と分子標的療法の開発2018
- Author(s)
  伊藤匠, 波多野良, 大沼圭, 岩田哲史, 奥村康, 森本幾夫
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H02782
[Presentation] CD26/DPPⅣはエンドモルフィンによる機械的かゆみを制御する2018
- Author(s)
  古宮栄利子、波多野良、伊藤匠、松田浩則、大沼圭，森本幾夫、冨永光俊、髙森建二
- Organizer
  第28回国際痒みシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05345
[Presentation] Interleukin-26-targeted therapy for the control of chronic GVHD.2018
- Author(s)
  Ryo Hatano, Haruna Otsuka, Eriko Komiya, Takumi Itoh, Noriaki Iwao, Taketo Yamada, Chikao Morimoto, KeiOhnuma.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05345
[Presentation] 全身性エリテマトーデスのステロイド減量困難例における CD26陰性T細胞サブセットの増加について2018
- Author(s)
  波多野良, 大沼圭, 石井智徳, 伊藤匠, 岩田哲史, 奥村康, 関川巖, 森本幾夫
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H02782
[Presentation] 機械的かゆみの調節メカニズムの解明2018
- Author(s)
  古宮栄利子、波多野良、大塚春奈、伊藤匠、松田浩則、須賀康、大沼圭、冨永光俊、森本幾夫、髙森建二
- Organizer
  第82回日本皮膚科学会東京支部
- Data Source
  KAKENHI-PROJECT-16H05345
[Presentation] Interleukin-26-targeted therapy for the control of chronic GVHD2018
- Author(s)
  Hating R, Otsuka H, Komiya E, Itoh T, Iwao I, Yamada T, Morimoto C, Ohnuma K.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02782
[Presentation] 急性GVHDマウスモデルにおけるHMGB1の動態に関する検討2018
- Author(s)
  岩尾憲明、大沼圭、大塚春奈、波多野良、古宮栄利子、伊藤匠、森本幾夫
- Organizer
  第40回日本造血細胞移植学会
- Data Source
  KAKENHI-PROJECT-16H05345
[Presentation] CD26/DPPIV regulates mechanical itch in a mechanistically distinct manner from chemical itch2017
- Author(s)
  Eriko Komiya, Ryo Hatano, Haruna Otsuka, Takumi Itoh, Hiroto Yamazaki, Mitsutoshi Tominaga, Kenji Takamori, Kei Ohnuma, Chikao Morimoto.
- Organizer
  第42回日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-16H05345
[Presentation] 全身性エリテマトーデスのステロイド治療抵抗性とCD26陰性T細胞サブセットとの関係性について.2017
- Author(s)
  波多野良、大沼圭、石井智徳、岩田哲史、奥村康、関川巖、森本幾夫.
- Organizer
  第61回日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-16H05345
[Presentation] The regulation of pruritus in psoriasis and atopic dermatitis-a possible role for CD26/DPPIV.2017
- Author(s)
  Eriko Komiya, Ryo Hatano, Haruna Otsuka, Takumi Itoh, Hiroto Yamazaki, Taketo Yamada, Yasushi Suga, Utako Kimura, Mitsutoshi Tominaga, Kenji Takamori, Kei Ohnuma, Chikao Morimoto.
- Organizer
  9th World Congress on Itch
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05345
[Presentation] 全身性エリテマトーデスのステロイド治療抵抗性とCD26陰性T細胞サブセットとの関係性について2017
- Author(s)
  波多野良、大沼圭、石井智徳、岩田哲史、奥村康、関川嚴、森本幾夫
- Organizer
  日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-15H04879
[Presentation] 急性GVHDマウスモデルにおけるHMGB1の動態に関する検討2017
- Author(s)
  岩尾憲明、大沼圭、大塚春奈、波多野良、古宮栄利子、伊藤匠、森本幾夫
- Organizer
  日本造血幹細胞移植学会総会
- Data Source
  KAKENHI-PROJECT-15H04879
[Presentation] 乾癬においてCD26/DPPIVはsubstance Pを切断してかゆみを調節する2016
- Author(s)
  古宮栄利子、波多野良、大塚春奈、伊藤匠、山田健人、冨永光俊、高森健二、大沼圭、森本幾夫
- Organizer
  第31回日本乾癬学会学術大会
- Place of Presentation
  宇都宮市
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-15H04879
[Presentation] CD26/DPPIV-mediated regulation of pruritus in psoriasis.2016
- Author(s)
  Komiya E, Hatano R, Otsuka H, Itoh T, Yamada T, Tomonaga M, Takamori K, Ohnuma K, Morimoto C.
- Organizer
  第41回研究皮膚科学会　年次学術大会・総会
- Place of Presentation
  仙台市
- Year and Date
  2016-12-09
- Data Source
  KAKENHI-PROJECT-15H04879
[Presentation] CD26陽性T細胞サブセットに基づく全身性エリテマトーデスの病態解析2016
- Author(s)
  波多野良、大沼圭、石井智徳、岩田哲史、奥村康、関川巖、森本幾夫
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  横浜市
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15H04879
[Presentation] First　-in-　human　phase I administration of YS110, a monoclonal antibody directed against the CD26 immunostimulatory molecule in advanced cancer patients2015
- Author(s)
  Angevin E, Isambert N,Trillet-Lenoir VN,You V, Alxandre J, Zalcman G, Viel P, Farace F, Valleix F, Podoll T, Kuramochi Y, Miyashita I, HosonoO, Dang NH, Ohnuma K, Yamada T, Kaneko Y, Morimoto C.
- Organizer
  The 2015 ASCO
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670486
[Presentation] T細胞共刺激分子CD26に基づく全身性エリテマトーデスの病態および疾患活動性の新規バイオマーカーの探索2015
- Author(s)
  波多野良, 大沼圭, 石井智徳, 岩田哲史, 奥村康, 関川巖, 森本幾夫
- Organizer
  第59回日本リウマチ学会総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15H04879
[Presentation] T細胞共刺激分子CD26に基づく全身性エリテマトーデスの病態および疾患活動性の新規バイオマーカーの探索.2015
- Author(s)
  波多野良, 大沼圭, 石井智徳, 岩田哲史, 奥村康, 関川巖, 森本幾夫
- Organizer
  第59回日本リウマチ学会学術集会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26670486
[Presentation] Anti-interleukin-26 therapy for lung fibrosis of GVHD2015
- Author(s)
  Ryo Hatano, Taketo Yamada, Haruna Otsuka, Eriko Komiya, Noriaki Iwao, Ko Okumura, Chikao Morimoto, Kei Ohnuma
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  金沢市
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15H04879
[Presentation] Clinical significance of soluble CD26 in malignant pleural mesotheliom2015
- Author(s)
  Fujimoto N, Ohnuma K, Aoe K, Hosono O, Yamada T, Kishimoto T, Morimoto C
- Organizer
  The 103th Annual Meeting of American Association of Cancer Research
- Place of Presentation
  Philadelphia, USA.
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670486
[Presentation] Humanized anti-CD26 mAb Leads to Prophylaxis and Treatment of GVHD in hu-PBL-NOG Model Mice2012
- Author(s)
  Hatano R, Ohnuma K, et al
- Organizer
  第74回日本血液学会総会
- Place of Presentation
  京都市
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] CD26分子を用いたGVHDなど難治性免疫疾患への新規治療法開発2011
- Author(s)
  大沼圭、他
- Organizer
  第55回日本リウマチ学会総会
- Place of Presentation
  神戸市
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] A novel immunoregulation therapy targeting CD26 molecule for intractable autoimmune diseases : a new aspect of T-cell costimulation blocking therapy2011
- Author(s)
  Ohnuma K, Morimoto C
- Organizer
  Tokyo-Shanghai Workshop on Rheumatology
- Place of Presentation
  千葉県浦安市
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] A novel immunoregulation therapy targeting CD26 molecule for intractable autoimmune diseases : a new aspect of T-cell costimulation blocking therapy2011
- Author(s)
  Ohnuma K, Morimoto C
- Organizer
  Tokyo- Shanghai Workshop on Rheumatology
- Place of Presentation
  Urayasu, Japan
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] CD26分子を用いたGVHDなど難治性免疫疾患への新規治療法開発2011
- Author(s)
  大沼圭, 他
- Organizer
  日本リウマチ学会総会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] CD26 blockade by humanized monoclonal antibody leads to prophylaxis and treatment of graft-versus-host disease (GVHD) in hu-PBL NOG model mice2011
- Author(s)
  Hatano R, Ohnuma K, et al.
- Organizer
  米国血液学会
- Place of Presentation
  San Diego, LA.(U.S.A.)
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] CD26 blockade by humanized monoclonal antibody leads to prophylaxis and treatment of graft-versus-host disease (GVHD) in hu-PBL NOG model mice2011
- Author(s)
  Hatano R, Ohnuma K, et al
- Organizer
  The 53th Annual Meeting, American Society of Hematology
- Place of Presentation
  San Diego, LA, USA
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] A Novel Function of CD26-Mediated Costimulation in the cytotoxic activity of human CD8^+ T cells in xenogeneic graft-versus-host disease mice model2010
- Author(s)
  Hatano R, Ohnuma K, et al
- Organizer
  The 14th International Congress of Immunolgy
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] A Novel Function of CD26-Mediated Costimulation in the Cytotoxic Activity of Human CD8+ T Cells in Xenogeneic Graft-Versus-Host Disease Mice Model2010
- Author(s)
  Hatano R, Ohnuma K, et, al.
- Organizer
  国際免疫学会
- Place of Presentation
  神戸ポートピアホテル国際展示場
- Year and Date
  2010-08-22
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] Novel Function of CD26-Mediated Costimulation in the cytotoxic activity of human CD8^+ T cells in xenogeneic chronic GVHD and GVL mice model2009
- Author(s)
  Hatano R, Ohnuma K, et al
- Organizer
  The 51th Annual Meeting, American Society of Hematology
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] CD26 expression of vascular endothelium and its role in inflammatory endothelial cell injury.2009
- Author(s)
  高澤渉、大沼圭, 他
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  京都市
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] CD26/DPP IVのヒトT細胞機能と活性化:ベンチからベッドまで2009
- Author(s)
  森本幾夫、大沼圭
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-17109011
[Presentation] CD26 expression of vascular endothelium and its role in inflammatory endothelial cell injury2009
- Author(s)
  高澤渉、大沼圭、他
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  京都市
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] A Novel Function of CD26-Madiate Costimulation in the Cytotoxic Activity of Human CD8+ T cells in Xenogeneic Chronic Graft-Versus-Host Disease (cGVHD) and GVL Mice Model2009
- Author(s)
  Hatano R, Ohnuma K, Yamada T, et al, Morimoto C.
- Organizer
  第51回アメリカ血液学会 (ASH)
- Place of Presentation
  Morial Convention Center (New Orleans, U. S. A.)
- Year and Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-17109011
[Presentation] CD26/DPPIVのヒトT細胞機能と活性化 : ベンチからベッドまで2009
- Author(s)
  森本幾夫, 大沼圭
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-17109011
[Presentation] A Novel Function of CD26-Mediated Costimulation in the Cytotoxic Activity of Human CD8+ T Cells in Xenogeneic Chronic GVHD and GVL Mice Model.2009
- Author(s)
  Hatano R, Ohnuma K, et al.
- Organizer
  51th Annual Meeting, American Society of Hematology
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-21679005
[Presentation] A Novel Function of CD26-Madiate Costimulation in the Cytotoxic Activity of Human CD8+T cells in Xenogeneic Chronic Graft-Versus-Host Disease(cGVHD)and GVL Mice Model.2009
- Author(s)
  Hatano R, Ohnuma K, Yamada T, et al, Morimoto C.
- Organizer
  第51回アメリカ血液学会(ASH)
- Place of Presentation
  Morial Convention Center(New Orleans, U.S.A.)
- Year and Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-17109011
[Presentation] ヒト型抗CD26モノローナル抗体による移植片対宿主病の治療法の開発2008
- Author(s)
  大沼圭他
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都市
- Year and Date
  2008-10-12
- Data Source
  KAKENHI-PROJECT-19591240
[Presentation] `ヒト型抗CD26モノクローナル抗体による移植片対宿主病の治療法の開発2008
- Author(s)
  大沼圭、山田健人、高橋望、遠藤裕子、細野治、森本幾夫
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都市
- Year and Date
  2008-10-12
- Data Source
  KAKENHI-PROJECT-19591240
[Presentation] L-10産生誘導によるCD26共刺激経路のnegative feedback機構の解析
- Author(s)
  波多野良, 大沼圭, 岩田哲史, 石井智徳, 関川巖, 森本幾夫
- Organizer
  第58回日本リウマチ学会学術集会
- Place of Presentation
  グランドプリンスホテル新高輪（東京）
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-26670486
[Presentation] DPP4阻害剤の服用によって誘発される多関節症とそのバイオマーカー
- Author(s)
  1)大沼圭, 斉藤辰彦, 波多野良, 岩田哲史, 鈴木博史, 森本幾夫
- Organizer
  第58回日本リウマチ学会学術集会
- Place of Presentation
  グランドプリンスホテル新高輪（東京）
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-26670486

1. MORIMOTO Chikao (30119028)

# of Collaborated Projects: 7 results

# of Collaborated Products: 103 results
2. IWATA Satoshi (00396871)

# of Collaborated Projects: 7 results

# of Collaborated Products: 26 results
3. IWAO NORIAKI (00309139)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
4. 波多野良 (30638789)

# of Collaborated Projects: 3 results

# of Collaborated Products: 31 results
5. HOSONO Osamu (50190210)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
6. YAMOCHI Tadanori (80306844)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
7. KAWASAKI Hiroshi (80280957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. IKEDA Teturo (10360489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 伊藤匠 (80811835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 川崎剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 山田健人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 山田幸司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 田中廣壽

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 菅野真莉加

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oonuma Kei 大沼 圭

OHNUMA Kei 大沼 圭

Research Projects

Research Products

Co-Researchers

Molecular understanding of an innovative therapy for chronic inflammatory diseases targeting human Th17 cytokine IL-26

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Understanding of detailed pathology and development of novel molecular targeted therapy for the treatment of refractory chronic inflammatory diseases based on the inflammatory cytokine IL-26

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Scientific research on development of anti-fibrotic agent targeting multi-organ profibrotic factor IL-26 in GVHDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular understanding of CD26-mediated immune regulatory mechanism and development of novel molecular targeted therapy for the treatment of refractory autoimmune diseases

Principal Investigator

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Research Field

Research Institution

Prevention of chronic GVHD onset by HMGB1 inhibiton of DPP4

Principal Investigator

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Research Institution

Large molecular complex of cell surface in malignant pleural mesotheliom as a novel treatment targetPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Mechanism of lung fibrosis in chronic GVHDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of CD26 molecule in the infection of MERS(Middle East respiratory syndrome) virus and development of new therapy

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

新規T細胞共刺激分子CD26ーカベオリンを標的とする免疫療法開発の基礎的研究Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Scientific research of transplantation tolerance targeting CD26/caveolin-1 costimulation pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Scientific research for developing a novel immunotherapy targetinginteraction of CD26 and its ligandPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the Ro52's function and structure and biological significance of autoimmune disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic Approach for the Development of Molecular Target Therapy for Autoimmune Diseases and Immune-Mediated Disorders.

Principal Investigator

Project Period (FY)

Oonuma Kei 大沼圭

OHNUMA Kei 大沼圭