Morino Hiroyuki 森野豊之

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MORINO Hiroyuki 森野豊之

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Researcher Number	10397953
Other IDs	https://orcid.org/0000-0002-5190-3547
Affiliation (Current)	2025: 徳島大学, 大学院医歯薬学研究部(医学域), 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 徳島大学, 大学院医歯薬学研究部(医学域), 教授 2015 – 2017: 広島大学, 原爆放射線医科学研究所, 准教授 2011 – 2013: 広島大学, 原爆放射線医科学研究所, 助教 2007 – 2009: 広島大学, 原爆放射線医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Pathological medical chemistry / Neurology Except Principal Investigator Basic Section 52020:Neurology-related / Neurology / Basic Section 51030:Pathophysiologic neuroscience-related / Basic / Social brain science
Keywords	Principal Investigator ライソソーム / 凝集体形成 / オートファジー / α-シヌクレイン / 品質管理 / エンドソーム-ライソソーム系 / パーキンソン病 / ミトコンドリア / 脳神経疾患 / 遺伝子 / 神経分子病態学 / 筋萎縮性側索硬化症 / 神経分子病態 … More Except Principal Investigator … More 筋萎縮性側索硬化症 / 脳神経疾患 / 脊髄小脳変性症 / 神経科学 / 遺伝学 / ALS / TMEM106B / OPTN / 逆行性進展 / necroptosis / ノックインマウス / 変異遺伝子スクリーニング / Fused in sarcoma (FUS) / 低分子スクリーニング / RNA / DHX30 / FUS / CACNA1G / プルキンエ細胞 / TDP-43 / 遺伝性脊髄小脳変性症 / 遺伝子 / Ca チャンネル / ゲノム解析 / SNP / 劣性遺伝 / 臨床神経分子遺伝学 Less

Necroptosisを介したALSの運動神経変性の病態機序と新規治療の探索
- Principal Investigator
  
  丸山博文
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Hiroshima University
Elucidation of alpha-synuclein aggregation mechanism in Parkinson's disease and application to novel therapeutic strategiesPrincipal Investigator
- Principal Investigator
  
  森野豊之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  The University of Tokushima
新規ミトコンドリア蛋白質の構造異常によるALS病態の解析と評価モデル系の開発
- Principal Investigator
  
  漆谷真
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
A new oligonucleotide treatment with CRISPR/Cas13 using model mice of spinocerebellar ataxia
- Principal Investigator
  
  MATSUDA Yukiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Hiroshima University
Identification of TDP-43 related genes using gene trap
- Principal Investigator
  
  Kawakami Hideshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Hiroshima University
Evaluation of involvement in neurodegeneration by collapse of mitochondrial DNA maintenance mechanism using iPS cellsPrincipal Investigator
- Principal Investigator
  
  Morino Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Hiroshima University
Study of cerebellum disturbance by genetic approaches
- Principal Investigator
  
  Kawakami Hideshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Basic / Social brain science
- Research Institution
  Hiroshima University
Elucidation of the molecular mechanism caused by the neurotoxicity of OPTN mutations in ALSPrincipal Investigator
- Principal Investigator
  
  MORINO Hiroyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Hiroshima University
Novel Genes of Autosomal Recessive Spinocerebellar Degeneration
- Principal Investigator
  
  KAWAKAMI Hideshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Hiroshima University

[Journal Article] Clinical and Pathological Features of FTDP‐17 with MAPT p.K298_H299insQ Mutation2024
- Author(s)
  Morino Hiroyuki、Kurashige Takashi、Matsuda Yukiko、Ono Maiko、Sahara Naruhiko、Miyasaka Tomohiro、Soeda Yoshiyuki、Shimada Hitoshi、Yamazaki Yu、Takahashi Tetsuya、Izumi Yuishin、Ito Hidefumi、Maruyama Hirofumi、Higuchi Makoto、Arihiro Koji、Suhara Tetsuya、Takashima Akihiko、Kawakami Hideshi
- Journal Title
  
  Movement Disorders Clinical Practice
  
  Volume: - Issue: 6 Pages: 720-727
- DOI
  10.1002/mdc3.14042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06828
[Journal Article] Kv11 (ether-a-go-go-related gene) voltage-dependent K + channels promote resonance and oscillation of subthreshold membrane potentials2021
- Author(s)
  Matsuoka Toshinori, Yamasaki Miwako, Abe Manabu, Matsuda Yukiko, Morino Hiroyuki, Kawakami Hideshi, Sakimura Kenji, Watanabe Masahiko, Hashimoto Kouichi
- Journal Title
  
  The Journal of Physiology
  
  Volume: 599(2) Issue: 2 Pages: 547-569
- DOI
  10.1113/jp280342
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07994, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-17K01972, KAKENHI-PROJECT-17H03551, KAKENHI-PROJECT-20H03410, KAKENHI-PROJECT-18KK0458
[Journal Article] Middle-age-onset cerebellar ataxia caused by a homozygous TWNK variant: a case report2020
- Author(s)
  Kume Kodai、Morino Hiroyuki、Miyamoto Ryosuke、Matsuda Yukiko、Ohsawa Ryosuke、Kanaya Yuhei、Tada Yui、Kurashige Takashi、Kawakami Hideshi
- Journal Title
  
  BMC Medical Genetics
  
  Volume: 21(1) Issue: 1
- DOI
  10.1186/s12881-020-01002-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07994
[Journal Article] Genetic screening for potassium channel mutations in Japanese autosomal dominant spinocerebellar ataxia2020
- Author(s)
  Tada Yui、Kume Kodai、Matsuda Yukiko、Kurashige Takashi、Kanaya Yuhei、Ohsawa Ryosuke、Morino Hiroyuki、Tabu Hayato、Kaneko Satoshi、Suenaga Toshihiko、Kakizuka Akira、Kawakami Hideshi
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 65(4) Issue: 4 Pages: 363-369
- DOI
  10.1038/s10038-019-0717-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07994, KAKENHI-PROJECT-19H03435
[Journal Article] Retinitis pigmentosa prior to familial ALS caused by a homozygous cilia and flagella-associated protein 410 mutation2020
- Author(s)
  Kurashige Takashi、Morino Hiroyuki、Matsuda Yukiko、Mukai Tomoya、Murao Tomomi、Toko Megumi、Kume Kodai、Ohsawa Ryosuke、Torii Tsuyoshi、Tokinobu Hiroshi、Maruyama Hirofumi、Kawakami Hideshi
- Journal Title
  
  Journal of Neurology, Neurosurgery & Psychiatry
  
  Volume: 91(2) Issue: 2 Pages: 220-222
- DOI
  10.1136/jnnp-2019-321279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07994
[Journal Article] Optineurin regulates osteoblastogenesis through STAT12020
- Author(s)
  Mizuno Noriyoshi、Iwata Tomoyuki、Ohsawa Ryosuke、Ouhara Kazuhisa、Matsuda Shinji、Kajiya Mikihito、Matsuda Yukiko、Kume Kodai、Tada Yui、Morino Hiroyuki、Yoshimoto Tetsuya、Ueki Yasuyoshi、Mihara Keichiro、Sotomaru Yusuke
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 525(4) Issue: 4 Pages: 889-894
- DOI
  10.1016/j.bbrc.2020.03.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07994, KAKENHI-PROJECT-18H02978, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K18999
[Journal Article] Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel CaV3.1 caused by a mutationresponsible for spinocerebellar ataxia2020
- Author(s)
  N. Hara, H. Morino, Y. Matsuda, K. Satoh, K. Hashimoto, H. Maruyama, H. Kawakami
- Journal Title
  
  Molecular Brain
  
  Volume: 13 Issue: 1 Pages: 163-163
- DOI
  10.1186/s13041-020-00700-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09125, KAKENHI-PROJECT-19K07994, KAKENHI-PROJECT-17H03551
[Journal Article] Aggressive periodontitis and NOD2 variants2020
- Author(s)
  Mizuno Noriyoshi, Kume Kodai, Nagatani Yukiko, Matsuda Shinji, Iwata Tomoyuki, Ouhara Kazuhisa, Kajiya Mikihito, Takeda Katsuhiro, Matsuda Yukiko, Tada Yui, Ohsawa Ryosuke, Morino Hiroyuki, Mihara Keichiro, Fujita Tsuyoshi, Kawaguchi Hiroyuki, Shiba Hideki, Kawakami Hideshi, Kurihara Hidemi
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 65(10) Issue: 10 Pages: 841-846
- DOI
  10.1038/s10038-020-0777-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07994, KAKENHI-PROJECT-18H02978, KAKENHI-PROJECT-18K09599
[Journal Article] The first Japanese case of primary familial brain calcification caused by an MYORG variant2020
- Author(s)
  Kume Kodai, Takata Tadayuki, Morino Hiroyuki, Matsuda Yukiko, Ohsawa Ryosuke, Tada Yui, Kurashige Takashi, Kawakami Hideshi
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 65(10) Issue: 10 Pages: 917-920
- DOI
  10.1038/s10038-020-0779-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07994
[Journal Article] Biallelic mutation of HSD17B4 induces middle age-onset spinocerebellar ataxia2020
- Author(s)
  Matsuda Yukiko、Morino Hiroyuki、Miyamoto Ryosuke、Kurashige Takashi、Kume Kodai、Mizuno Noriyoshi、Kanaya Yuhei、Tada Yui、Ohsawa Ryosuke、Yokota Kazunori、Shimozawa Nobuyuki、Maruyama Hirofumi、Kawakami Hideshi
- Journal Title
  
  Neurology Genetics
  
  Volume: 6(1) Issue: 1
- DOI
  10.1212/nxg.0000000000000396
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07994
[Journal Article] C-terminal mutations in SYNE1 are associated with motor neuron disease in patients with SCAR82019
- Author(s)
  Kume Kodai、Morino Hiroyuki、Komure Osamu、Matsuda Yukiko、Ohsawa Ryosuke、Kurashige Takashi、Kanaya Yuhei、Tada Yui、Kawakami Hideshi
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 402 Pages: 118-120
- DOI
  10.1016/j.jns.2019.05.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07994
[Journal Article] PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation2017
- Author(s)
  Miyamoto Tatsuo、Akutsu Silvia Natsuko、Fukumitsu Akihiro、Morino Hiroyuki、Masatsuna Yoshinori、Hosoba Kosuke、Kawakami Hideshi、Yamamoto Takashi、Shimizu Kenji、Ohashi Hirofumi、Matsuura Shinya
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Issue: 22 Pages: 4429-4440
- DOI
  10.1093/hmg/ddx330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26242085, KAKENHI-PROJECT-15H04321, KAKENHI-PROJECT-15K15017, KAKENHI-PROJECT-15K15083
[Journal Article] First report of a Japanese family with spinocerebellar ataxia type 10: The second report from Asia after a report from China2017
- Author(s)
  Naito Hiroyuki、Takahashi Tetsuya、Kamada Masaki、Morino Hiroyuki、Yoshino Hiroyo、Hattori Nobutaka、Maruyama Hirofumi、Kawakami Hideshi、Matsumoto Masayasu
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 5 Pages: 0177955-0177955
- DOI
  10.1371/journal.pone.0177955
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26242085, KAKENHI-PROJECT-15K15083
[Journal Article] Causative Genes for Amyotrophic Lateral Sclerosis2016
- Author(s)
  Maruyama H, Morino H, Kawakami H
- Journal Title
  
  Brain Nerve
  
  Volume: 68 Pages: 1081-1086
- NAID
  40020964548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15083
[Journal Article] Exome sequencing identifies a novel intronic mutation in ENG that cause recurrence of pulmonary arteriovenous malformations.2015
- Author(s)
  Kawarai T, Saji N, Miyamoto R, Sato T, Morino H, Orlacchio A, Oki R, Kimura K and Kaji R.
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 351 Issue: 1-2 Pages: 231-233
- DOI
  10.1016/j.jns.2015.02.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461294, KAKENHI-PROJECT-15K15083
[Journal Article] A mutation in the low voltage -gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia.2015
- Author(s)
  Morino H., Matsuda Y., Muguruma K., Miyamoto R., Ohsawa R., Ohtake T., Otobe R., Watanabe M., Maruyama H., Hashimoto K., Kawakami H.
- Journal Title
  
  Molecular Brain
  
  Volume: 8 Issue: 1 Pages: 1-9
- DOI
  10.1186/s13041-015-0180-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07089, KAKENHI-PROJECT-15K15083, KAKENHI-PLANNED-23111008, KAKENHI-PLANNED-25117006, KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-26293211, KAKENHI-PROJECT-26242085
[Journal Article] Mutations in Twinkle primase-helicase cause Perrault syndrome with neurologic features.2014
- Author(s)
  Morino H
- Journal Title
  
  Neurology
  
  Volume: 83 Issue: 22 Pages: 2054-2061
- DOI
  10.1212/wnl.0000000000001036
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23111008, KAKENHI-PROJECT-26242085, KAKENHI-PROJECT-26293211
[Journal Article] DYT6 in Japan-genetic screening and clinical characteristics of the patients.2014
- Author(s)
  Miyamoto R, Koizumi H, Morino H, Kawarai T, Maruyama H, Mukai Y, Miyashiro A, Sako W, Izumi Y, Kawakami H, Kaji R.
- Journal Title
  
  Mov Disord.
  
  Volume: 29 Issue: 2 Pages: 278-280
- DOI
  10.1002/mds.25745
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111008, KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-24390223, KAKENHI-PROJECT-26461294
[Journal Article] Exome sequencing reveals a novel TTC19 mutation in an autosomal recessive spinocerebellar ataxia patient.2014
- Author(s)
  Morino H, Miyamoto R, Ohnishi S, Maruyama H, Kawakami H
- Journal Title
  
  BMC Neurol
  
  Volume: 14 Issue: 1 Pages: 5-5
- DOI
  10.1186/1471-2377-14-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591246
[Journal Article] Exome sequencing reveals a novel MRE11 mutation in a patient with progressive myoclonic ataxia.2014
- Author(s)
  Miyamoto R, Morino H, Yoshizawa A, Miyazaki Y, Maruyama H, Murakami N, Fukada K, Izumi Y, Matsuura S, Kaji R, Kawakami H.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 337 Issue: 1-2 Pages: 219-223
- DOI
  10.1016/j.jns.2013.11.032
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111008, KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-24310043, KAKENHI-PROJECT-24390223, KAKENHI-PROJECT-24651222, KAKENHI-PUBLICLY-25113521
[Journal Article] Exome sequencing reveals a novel ANO10 mutation in a Japanese patient with autosomal recessive spinocerebellar ataxia.2014
- Author(s)
  Maruyama H, Morino H, Miyamoto R, Murakami N, Hamano T, Kawakami H.
- Journal Title
  
  Clin Genet.
  
  Volume: 85 Issue: 3 Pages: 296-297
- DOI
  10.1111/cge.12140
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111008, KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-23659456
[Journal Article] Detecting gene mutations in Japanese Alzheimer's patients by semiconductor sequencing.2014
- Author(s)
  Yagi R
- Journal Title
  
  Neurobiol Aging
  
  Volume: 35 Issue: 7 Pages: 1780.e1-1780.e5
- DOI
  10.1016/j.neurobiolaging.2014.01.023
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111008, KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-26293211
[Journal Article] Convenient diagnosis of spinal and bulbar muscular atrophy using a microchip electrophoresis system2013
- Author(s)
  Maruyama H, Morino H, Izumi Y, Noda K, Kawakami H
- Journal Title
  
  Am J Neurodegener Dis
  
  Volume: 2(1) Pages: 35-9
- URL
  http://www.ajnd.us/files/ajnd1212003.pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591246
[Journal Article] Convenient diagnosis of spinal and bulbar muscular atrophy using a microchip electrophoresis system.2013
- Author(s)
  Maruyama H, Morino H, Izumi Y, Noda K, Kawakami H
- Journal Title
  
  Am J Neurodegener Dis
  
  Volume: 2 Pages: 35-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591246
[Journal Article] Cerebellar ataxia with SYNE1 mutation accompanying motor neuron disease.2013
- Author(s)
  Izumi Y, Miyamoto R, Morino H, Yoshizawa A, Nishinaka K, Udaka F, Kameyama M, Maruyama H, Kawakami H
- Journal Title
  
  Neurology
  
  Volume: 80 Issue: 6 Pages: 600-601
- DOI
  10.1212/wnl.0b013e3182815529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-23659456
[Journal Article] Oromandibular dystonia associated with SCA36.2013
- Author(s)
  Miyashiro A, Sugihara K, Kawarai T, Miyamoto R, Izumi Y, Morino H, Maruyama H, Orlacchio A, Kawakami H, Kaji R.
- Journal Title
  
  Mov Disord.
  
  Volume: 28 Issue: 4 Pages: 558-559
- DOI
  10.1002/mds.25304
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111008, KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-23659456
[Journal Article] Severe brain atrophy after long-term survival seen in siblings with familial amyotrophic lateral sclerosis and a mutation in the optineurin gene : a case series2012
- Author(s)
  Ueno H, Kobatake K, Matsumoto M, Morino H, Maruyama H, Kawakami H
- Journal Title
  
  J Med Case Reports
  
  Volume: 5 Issue: 1 Pages: 573-573
- DOI
  10.1186/1752-1947-5-573
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111008, KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-23790993
[Journal Article] The clinical characteristics of spinocerebellar ataxia 36: a study of 2121 Japanese ataxia patients2012
- Author(s)
  Sugihara K, Maruyama H, Morino H, Miyamoto R, Ueno H, Matsumoto M, Kaji R, Kitaguchi H, Yukitake M, Higashi Y, Nishinaka K, Oda M, Izumi Y, Kawakami H
- Journal Title
  
  Mov Disord
  
  Volume: 27(9) Issue: 9 Pages: 1158-63
- DOI
  10.1002/mds.25092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-23659456, KAKENHI-PROJECT-23790993
[Journal Article] Screening for OPTN mutations in amyotrophic lateral sclerosis in a mainly Caucasian population2011
- Author(s)
  Sugihara K, Maruyama H, Kamada M, Morino H, Kawakami H
- Journal Title
  
  Neurobiol Aging
  
  Volume: 32(10) Issue: 10 Pages: 1923.e9-1923.e10
- DOI
  10.1016/j.neurobiolaging.2011.03.024
- NAID
  120005308210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591246
[Journal Article] Detection of large expansions in SCA8 using a fluorescent repeat-primed PCR assay2011
- Author(s)
  Tanaka E, Maruyama H, Morino H, Kawakami H
- Journal Title
  
  Hiroshima J Med Sci
  
  Volume: 60(3) Pages: 63-6
- NAID
  120005323966
- URL
  http://ir.lib.hiroshima-u.ac.jp/metadb/up/kiyo/AA00664312/HiroshimaJMedSci_60_63.pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591246
[Journal Article] The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population2011
- Author(s)
  Snapinn KW, Larson EB, Kawakami H, Ujike H, Borenstein AR, Izumi Y, Kaji R, Maruyama H, Mata IF, Morino H, Oda M, Tsuang DW, Yearout D, Edwards KL, Zabetian CP
- Journal Title
  
  Parkinsonism Relat Disord
  
  Volume: 17(6) Issue: 6 Pages: 473-5
- DOI
  10.1016/j.parkreldis.2011.01.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591246
[Journal Article] Homozygosity mapping on homozygosity haplotype analysis to detect recessive disease-causing genes from a small number of unrelated, outbred patients2011
- Author(s)
  Hagiwara K, Morino H, Shiihara J, Tanaka T, Miyazawa H, Suzuki T, Kohda M, Okazaki Y, Seyama K, Kawakami H
- Journal Title
  
  PLoS One
  
  Volume: 6(9) Issue: 9 Pages: e25059-e25059
- DOI
  10.1371/journal.pone.0025059
- NAID
  120005300511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591246
[Journal Article] LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease.2009
- Author(s)
  Zabetian CP, Yamamoto M, Lopez AN, Ujike H, Mata IF, Izumi Y, Kaji R, Maruyama H, Morino H, Oda M, Hutter CM, Edwards KL, Schellenberg GD, Tsuang DW, Yearout D, Larson EB, Kawakami H.
- Journal Title
  
  Mov Disord 24(7)
  
  Pages: 1034-1041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390241
[Journal Article] Screening for TARDBP mutations in Japanese familial amyotrophic lateral sclerosis.2009
- Author(s)
  Kamada M, Maruyama H, Tanaka E, Morino H, Wate R, Ito H, Kusaka H, Kawano Y, Miki T, Nodera H, Izumi Y, Kaji R, Kawakami H
- Journal Title
  
  J Neurol Sci 284(1-2)
  
  Pages: 69-71
- NAID
  120001898369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390241
[Journal Article] The CNTN4 c. 4256C>T mutation is rare in Japanese with inherited spinocerebellar ataxia.2008
- Author(s)
  Tanaka E, Maruyama H, Morino H, Nakajima E, Kawakami H
- Journal Title
  
  J Neurol Sci 266(1-2)
  
  Pages: 180-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390241
[Journal Article] Pathogenic expansions of the SCA6 locus are associated with a common CACNA1A haplotype across the globe: founder effect or predisposing chromosome?2008
- Author(s)
  Craig K, Takiyama Y, Soong BW, Jardim LB, Saraiva-Pereira ML, Lythgow K, Morino H, Maruyama H, Kawakami H, Chinnery PF
- Journal Title
  
  Eur J Hum Genet 16(7)
  
  Pages: 841-847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390241
[Patent] 伝子改変非ヒト動物及び脊髄小脳変性症の治療薬又は予防薬のスクリーニング法2018
- Inventor(s)
  川上秀史、森野豊之、松田由喜子
- Industrial Property Rights Holder
  広島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-031706
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-26242085
[Presentation] 孤発性筋萎縮性側索硬化症での中枢神経と骨格筋での病理所見の対比2023
- Author(s)
  倉重毅志、森野豊之、村尾智美、倉岡和矢、和泉唯信、大下智彦、丸山博文
- Organizer
  第64回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-23K27518
[Presentation] Transcriptomic analysis using model mice of spinocerebellar ataxia 422021
- Author(s)
  Matsuda Y, Morino H, Sotomaru Y, Kurashige T, Maruyama H, Kawakami H.
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07994
[Presentation] Biochemical analysis of middle-age-onset SCAR caused by a biallelic mutation of HSD17B42020
- Author(s)
  Matsuda Y, Morino H, Kurashige T, Miyamoto R, Maruyama H, Kawakami H
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07994
[Presentation] Degeneration of cerebellar Purkinje cells in the knock-in mice harboring SCA42 mutation2019
- Author(s)
  Matsuda Y, Morino H, Kurashige T, Nakayama H, Matsuoka T, Sotomaru Y, Hashimoto K, Kawakami H
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07994
[Presentation] Homozygous mutation in dehydrogenase domain of DBP cause slowly progressive spinocerebellar ataxia2019
- Author(s)
  Matsuda Y, Morino H, Miyamoto R, Kawakami H
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07994
[Presentation] 次世代シーケンスによる遺伝性神経変性疾患の原因遺伝子同定率2017
- Author(s)
  森野豊之
- Organizer
  第62回日本人類遺伝学会
- Data Source
  KAKENHI-PROJECT-15K15083
[Presentation] 優性遺伝性脊髄小脳変性症の新規原因遺伝子CACNA1Gの同定2016
- Author(s)
  森野　豊之
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-15K15083
[Presentation] 低電位活性型CaチャンネルCACNA1Gの変異は脊髄小脳変性症の原因である2016
- Author(s)
  森野　豊之
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-15K15083
[Presentation] OPTN-ALS患者由来iPS細胞研究に向けて2014
- Author(s)
  川上秀史,平木啓子,大澤亮介,鈴木秀規,吉澤明生,倉持真人,森野豊之,和泉唯信,梶龍兒,加藤英政,丸山博文
- Organizer
  平成25年度神経変性疾患に関する調査研究班分科班「病態に根ざしたALSの新規治療法開発」会議
- Place of Presentation
  東京
- Year and Date
  2014-01-17
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] 脊髄小脳失調症36型の臨床的特徴および日本人失調症患者2121人の病型別検討2013
- Author(s)
  杉原勝宣,丸山博文,宮本亮介,森野豊之,上野弘貴,松本昌泰,北口浩史,雪竹基弘,東靖人,西中和人,織田雅也,和泉唯信,川上秀史
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2013-06-01
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] Novel C10orf2 mutations cause Perrault syndrome2013
- Author(s)
  Kawakami H，Morino H，Miyamoto R，Maruyama H
- Organizer
  American Society of Human Genetics 63rd Annual Meeting
- Place of Presentation
  Boston (USA)
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] Novel C10orf2 mutations cause Perrault syndrome2013
- Author(s)
  Kawakami H,Morino H,Miyamoto R,Maruyama H
- Organizer
  American Society of Human Genetics 63rd Annual Meeting
- Place of Presentation
  Boston, USA
- Year and Date
  2013-10-23
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] Cerebellar ataxia with SYNE1 mutation accompanying motor neuron disease2013
- Author(s)
  Y Izumi, R Miyamoto, H Morino, A Yoshizawa, K Nishinaka, F Udaka, M Kameyama, H Maruyama, H Kawakami
- Organizer
  65th American Academy of Neurology Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2013-03-20
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] Perrault症候群の新規原因遺伝子2013
- Author(s)
  森野豊之,宮本亮介,丸山博文,川上秀史
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2013-05-31
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] VCP変異を認めたMND+IBMの臨床像と家族性ALSにおけるVCP変異の頻度2013
- Author(s)
  鎌田正紀,池田和代,久米広大,浦井由光,出口一志,峠哲男,宮本亮介,杉原勝宣,森野豊之,丸山博文,川上秀史
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2013-05-31
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] 次世代シーケンサーで確認したSYNE1変異による脊髄小脳変性症の臨床像2013
- Author(s)
  和泉唯信,宮本亮介,森野豊之,吉澤明生,西中和人,宇高不可思,亀山正邦,丸山博文,川上秀史
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2013-05-31
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] Cerebellar ataxia with SYNE1 mutation accompanying motor neuron disease.2013
- Author(s)
  Y Izumi, R Miyamoto, H Morino, A Yoshizawa, K Nishinaka, F Udaka, M Kameyama, H Maruyama, H Kawakami
- Organizer
  65th American Academy of Neurology Annual Meeting
- Place of Presentation
  San Diego (USA)
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] Perrault症候群の新規原因遺伝子2013
- Author(s)
  森野豊之，宮本亮介，丸山博文，川上秀史
- Organizer
  日本人類遺伝学会第58回大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] SCA36の臨床的特徴2012
- Author(s)
  杉原勝宣,丸山博文,宮本亮介,森野豊之,上野弘貴,北口浩史,雪竹基弘,東靖人,西中和人,織田雅也,和泉唯信,川上秀史
- Organizer
  日本人類遺伝学会第57回大会
- Place of Presentation
  東京
- Year and Date
  2012-10-27
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] ALS関連遺伝子のスクリーニング2012
- Author(s)
  杉原勝宣,宮本亮介,鎌田正紀,森野豊之,丸山博文,川上秀史
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] Exome sequence identifies a novel MRE11 mutation in a patient with generalized myoclonic tremor2012
- Author(s)
  R Miyamoto, H Morino, H Maruyama, Y Izumi, R Kaji, H Kawakami
- Organizer
  62nd Annual Meeting of The American Society of Human Genetics
- Place of Presentation
  San Francisco, USA
- Year and Date
  2012-11-08
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] Exome sequencing identifies a novel MRE11 mutation in a patient with generalized myoclonic tremor2012
- Author(s)
  宮本亮介,森野豊之,丸山博文,和泉唯信,梶龍兒,川上秀史
- Organizer
  日本人類遺伝学会第57回大会
- Place of Presentation
  東京
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] Optineurin変異による筋萎縮性側索硬化症の臨床経過および原因遺伝子の頻度2011
- Author(s)
  丸山博文,和泉唯信,伊東秀文,森野豊之,阿部康二,杉原勝宣,宮本亮介,小畠敬太郎,川上秀史
- Organizer
  日本人類遺伝学会第56回大会
- Place of Presentation
  千葉
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] 筋萎縮性側索硬化症の原因遺伝子オプチニューリンの同定および頻度・臨床症状2011
- Author(s)
  丸山博文,森野豊之,伊東秀文,和泉唯信,鎌田正紀,萩原弘一,阿部康二,小牟禮修,小畠敬太郎,上野弘貴,青木正志,日下博文,梶龍兒,川上秀史
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-23591246
[Presentation] 家族性ALSおよび孤発性ALSにおけるTARDBP遺伝子変異の頻度検索2009
- Author(s)
  鎌田正紀, 丸山博文, 田中英司, 森野豊之, 伊東秀文, 日下博文, 野寺裕之, 和泉唯信, 梶龍兒, 川上秀史
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-19390241
[Presentation] 日本人筋萎縮性側索硬化症におけるTARDBP変異のスクリーニング2009
- Author(s)
  丸山博文, 鎌田正紀, 森野豊之, 田中英司, 和手麗香, 伊東秀文, 日下博文, 川上秀史
- Organizer
  日本人類遺伝学会第54回大会
- Place of Presentation
  東京
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-19390241
[Presentation] 脊髄小脳変性症の病型別頻度の検討2009
- Author(s)
  森野豊之, 田中英司, 丸山博文, 和泉唯信, 川上秀史
- Organizer
  日本人類遺伝学会第54回大会
- Place of Presentation
  東京
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-19390241
[Presentation] 遺伝性脊髄小脳失調症15型(SCA15)のスクリーニング2008
- Author(s)
  田中英司、森野豊之、丸山博文、川上秀史
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19390241
[Presentation] 一過性の構音障害、右顔面神経麻痺で発症したX-linked Charcot-Marie-Tooth disease (CMTX)2008
- Author(s)
  藤井裕樹、村上善生、野田公一、川上秀史、丸山博文、森野豊之
- Organizer
  第84回日本神経学会中国四国地方会
- Place of Presentation
  米子
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-19390241
[Presentation] 脊髄小脳変性症1836例の病型分類と地域別病型頻度の検討2007
- Author(s)
  森野豊之, 丸山博文, 和泉唯信, 織田雅也, 寺澤英夫, 田路浩正, 川上秀史
- Organizer
  第17回日本疫学会学術総会
- Place of Presentation
  広島
- Year and Date
  2007-01-27
- Data Source
  KAKENHI-PROJECT-19390241
[Presentation] 遺伝性脊髄小脳失調症16型(SCA16)のスクリーニング2007
- Author(s)
  田中英司, 森野豊之, 丸山博文, 川上秀史
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-17
- Data Source
  KAKENHI-PROJECT-19390241
[Presentation] Comprehensive Analysis of the LRRK2 Gene in Japanese Patients with Parkinson's Disease2007
- Author(s)
  CP. Zabetian, H Ujike, H Morino, M Yamamoto, M Oda, H Maruyama, Y Izumi, R Kaji, IF. Mata, SK. Ayres, GD. Schellenberg, EB. Larson, H Kawakami
- Organizer
  59th American Academy of Neurology Annual Meeting
- Place of Presentation
  Boston, USA
- Year and Date
  2007-05-05
- Data Source
  KAKENHI-PROJECT-19390241
[Presentation] 第16番染色体長腕連鎖型常染色体優性遺伝性脊髄小脳変性症(16q-ADCA)の地域別頻度と臨床症状の検討2007
- Author(s)
  森野豊之, 丸山博文, 和泉唯信, 織田雅也, 寺澤英夫, 田路浩正, 川上秀史
- Organizer
  日本人類遺伝学会第52回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19390241
[Presentation] 脊髄小脳変性症1836例の病型分類と地域別病型頻度の検討2007
- Author(s)
  森野豊之, 丸山博文, 和泉唯信, 織田雅也, 寺澤英夫, 田路浩正, 川上秀史
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-17
- Data Source
  KAKENHI-PROJECT-19390241
[Presentation] Perrault症候群の原因遺伝子C10orf2の変異によるmtDNA維持機構の障害
- Author(s)
  森野豊之、川上秀史
- Organizer
  日本人類遺伝学会第59回大会
- Place of Presentation
  東京
- Year and Date
  2014-11-20 – 2014-11-23
- Data Source
  KAKENHI-PROJECT-26242085
[Presentation] Optineurinは筋萎縮性側索硬化症の原因遺伝子である
- Author(s)
  丸山博文,森野豊之,和泉唯信,伊東秀文,川上秀史
- Organizer
  第108回日本内科学会講演会
- Place of Presentation
  (東日本大震災のため誌上発表)
- Data Source
  KAKENHI-PROJECT-23591246

1. KAWAKAMI Hideshi (70253060)

# of Collaborated Projects: 4 results

# of Collaborated Products: 48 results
2. MARUYAMA Hirofumi (90304443)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
3. 中森正博 (30881297)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MATSUDA Yukiko (10735301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
5. 大澤亮介 (20719356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 福士雅也 (50313515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 山本卓 (90244102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 外丸祐介 (90309352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 平木啓子 (10455397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 漆谷真 (60332326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 和泉唯信 (10335812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 守村敏史 (20333338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 依馬正次 (60359578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 倉重毅志 (20710627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. KAWARAI Toshitaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 梶龍兒

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 佐藤健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 佐藤裕哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 六車恵子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morino Hiroyuki 森野 豊之

MORINO Hiroyuki 森野 豊之

Research Projects

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Co-Researchers

Necroptosisを介したALSの運動神経変性の病態機序と新規治療の探索

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Elucidation of alpha-synuclein aggregation mechanism in Parkinson's disease and application to novel therapeutic strategiesPrincipal Investigator

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新規ミトコンドリア蛋白質の構造異常によるALS病態の解析と評価モデル系の開発

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A new oligonucleotide treatment with CRISPR/Cas13 using model mice of spinocerebellar ataxia

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Identification of TDP-43 related genes using gene trap

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Evaluation of involvement in neurodegeneration by collapse of mitochondrial DNA maintenance mechanism using iPS cellsPrincipal Investigator

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Study of cerebellum disturbance by genetic approaches

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Elucidation of the molecular mechanism caused by the neurotoxicity of OPTN mutations in ALSPrincipal Investigator

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Novel Genes of Autosomal Recessive Spinocerebellar Degeneration

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[Journal Article] Clinical and Pathological Features of FTDP‐17 with MAPT p.K298_H299insQ Mutation2024

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[Journal Article] Kv11 (ether-a-go-go-related gene) voltage-dependent K + channels promote resonance and oscillation of subthreshold membrane potentials2021

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[Journal Article] Middle-age-onset cerebellar ataxia caused by a homozygous TWNK variant: a case report2020

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[Journal Article] Genetic screening for potassium channel mutations in Japanese autosomal dominant spinocerebellar ataxia2020

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[Journal Article] Retinitis pigmentosa prior to familial ALS caused by a homozygous cilia and flagella-associated protein 410 mutation2020

Morino Hiroyuki 森野豊之

MORINO Hiroyuki 森野豊之