Yamamoto Takashi 山本卓

… Alternative Names

Researcher Number	90244102
Other IDs	https://orcid.org/0000-0002-6516-2903
External Links
Affiliation (Current)	2020: 広島大学, 統合生命科学研究科(理), 教授
Affiliation (based on the past Project Information) *help	2019 – 2020: 広島大学, 統合生命科学研究科(理), 教授 2014 – 2018: 広島大学, 理学研究科, 教授 2015 – 2017: 広島大学, 大学院理学研究科, 教授 2012 – 2016: 広島大学, 理学(系)研究科(研究院), 教授 2013: 広島大学, 大学院理学研究科, 教授 … More
Review Section/Research Field	Principal Investigator Developmental biology / Developmental biology / Biological Sciences / Bioinformatics/Life informatics / System genome science / Medical genome science Except Principal Investigator Developmental biology / Pediatrics / Integrative animal science / Biological Sciences … More
Keywords	Principal Investigator 発生・分化 / 遺伝子 / ゲノム / 発現制御 / バイオテクノロジー / ゲノム編集 / イモリ / 精子形成 / 減数分裂 / 棘皮動物 … More Except Principal Investigator FSH / 減数分裂開始 / 精原細胞 / ゲノム編集 / 精子分化 / 第一精母細胞 / セルトリ細胞 / 人工ヌクレアーゼ / cDNAクローニング / TALEN / 遺伝子 / アネキシン / JAK1 / cDNA / activin A / バイオテクノロジー / iPS細胞 / Annexin V / JAK 1 / Activin A / meiosis initiation / spermatogonia / イモリ / アポトーシス / プロラクチン / cycloheximide / newt / SCF / c-kit / BMP-2 / 発生・分化 / 培養 / IGF-I / FSH recepter / 抗がん剤 / グノム損傷 / DNA修復 / ゲノム損傷 / 実験動物 / ラット / 遺伝子改変 / TALENs / 乾燥耐性 / RNAi / 遺伝子発現系 / 昆虫 / オーミクス / 先天性好中球減少症 / 遺伝子編集 / 遺伝子修復 / ウェルナー症候群 / 遺伝子修正 / 脊髄小脳変性症 / Ca チャンネル / 脳神経疾患 / 神経科学 / 遺伝性脊髄小脳変性症 / spermatogenesis / Sertoli cells / チェックポイント / プロラクチン受容体 / RT-PCR / FSH受容体 / apoptosis / prolactin / checkpoint / BMP-2,-4 / 精子形成 / -4 / BMP受容体 / Meiosis initiation / Spermatogonia / Apoptosis / 4 / 放射線誘発突然変異 / ノックインマウス / トランスジェニックメダカ / 体細胞突然変異 / 生殖細胞突然変異 / 遺伝影響評価 / 環境変異原 / ゲノム解析 / 環境 / 突然変異 / 放射線 / リスク評価 / GFP / in vivo / 組織幹細胞 / CRISPR/Casシステム / ノックイン / エレクトポレーション / 慢性皮膚粘膜カンジダ症 / STAT1機能獲得型変異 / IL17RA / 造血細胞移植 / 疾患モデルマウス / STAT1 / 機能獲得型変異 / 原発性免疫不全症 / IL-17 / RORC / CMC / カンジダ / 全エクソーム解析 / 鳥類 / 性決定 / 多能性幹細胞 / 始原生殖細胞 / HEMGEN / ノックアウト / 応用動物 / 発生工学 / CRISPR/Cas9 / ニワトリ / マウス / 受精卵 / 核酸導入 / 核酸 / ゲノム / 膜性骨化 / Runx2 / 点変異 / 歯根 / 歯学 / 骨形成 / 変異 / 染色体微細構造 / FIB-SEM技術 / ゲノム編集技術 / 放射線感受性 Less

Morphological characteristics of the genome stress-induced chromosomal tether structureOngoing
- Principal Investigator
  
  宮本達雄
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Hiroshima University
Development of genome editing platform technology for various disease modelsPrincipal InvestigatorOngoing
- Principal Investigator
  
  山本卓
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical genome science
- Research Institution
  Hiroshima University
Investigation of molecular mechanism and therapeutic target of Chronic Mucocutaneous Candidiasis
- Principal Investigator
  
  OKADA SATOSHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Hiroshima University
Establishment of a new mouse model of cledocranial dysplasia by TALEN mediated genome editing
- Principal Investigator
  
  Shukunami Chisa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Application of lipofection-mediated genome editing in mouse zygotes created by IVF via ultra-superovulation
- Principal Investigator
  
  Nakagata Naomi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Integrative animal science
- Research Institution
  Kumamoto University
Study of cerebellum disturbance by genetic approaches
- Principal Investigator
  
  Kawakami Hideshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Basic / Social brain science
- Research Institution
  Hiroshima University
Development of a novel genome editing-mediated gene knock-in systemPrincipal Investigator
- Principal Investigator
  
  Yamamoto Takashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  System genome science
- Research Institution
  Hiroshima University
Functional identification of anhydrobiosis-related genes using genome editing technology
- Principal Investigator
  
  Kikawada Takahiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Insect science
- Research Institution
  National Agriculture and Food Research Organization
  National Institute of Agrobiological Sciences
Gene editing of iPS cells derived from patients with congenital phagocytic disorders
- Principal Investigator
  
  Kobayashi Masao
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Hiroshima University
Gene correction in iPS cells of premature aging syndrome toward clinical application by genome editing
- Principal Investigator
  
  SHIMAMOTO Akira
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
In vivo, in situ assessment of the mutagenic risk of radiation and environmental chemicals, using newly developed animal systems
- Principal Investigator
  
  NODA Asao
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Radiation Effects Research Foundation
Super-simplification of the genetically modified mouse production method using TALEN
- Principal Investigator
  
  YASUE Akihiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  The University of Tokushima
Development of genome editing technology in birds
- Principal Investigator
  
  Horiuchi Hiroyuki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Integrative animal science
- Research Institution
  Hiroshima University
Development of universal method for genome modification using zinc finger nucleasePrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Developmental biology
- Research Institution
  Hiroshima University
Production of knockout rats using TALENs
- Principal Investigator
  
  KANEKO Takehito
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyoto University
Quantitative analysis of cell-cell interaction responsible for the robustness of developmentPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Takashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Hiroshima University
抗がん剤が誘発する巨大DNA付加体の修復と致死効果
- Principal Investigator
  
  井出博
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
Gene expression noise during cell differentiation and its regulationPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Takashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Bioinformatics/Life informatics
  Developmental biology
- Research Institution
  Hiroshima University
Studies on the gene network responsible for the specific gene expression during developmentPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Takashi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Hiroshima University
棘皮動物Otx遺伝子の転写調節機構の解明Principal Investigator
- Principal Investigator
  
  山本卓
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
棘皮動物オーガナイザー因子の同定Principal Investigator
- Principal Investigator
  
  山本卓
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Hiroshima University
精原細胞の増殖と分化における骨形成タンパク質(BMP)の働きPrincipal Investigator
- Principal Investigator
  
  山本卓
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Developmental biology
- Research Institution
  Kumamoto University
Switching Mechanism for Meiosis Initiation or Apoptosis in Spermatogonia
- Principal Investigator
  
  ABE Shin-ichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Kumamoto University
シグナルトラップ法を用いたイモリ精巣からの増殖・分化因子のクローニングPrincipal Investigator
- Principal Investigator
  
  山本卓
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Developmental biology
- Research Institution
  Kumamoto University
Mechanism of apoptosis induction in amphibian spermatogonia by prolactin
- Principal Investigator
  
  ABE Shin-ichi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  Kumamoto University
両生類精巣における成長因子の探索と精子分化に対するその生理活性
- Principal Investigator
  
  安部真一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Kumamoto University
減数分裂誘導因子の研究
- Principal Investigator
  
  安部眞一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
カルシウム結合蛋白質アネキシンの減数分裂における働きPrincipal Investigator
- Principal Investigator
  
  山本卓
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Developmental biology
- Research Institution
  Kumamoto University
減数分裂誘導因子の研究
- Principal Investigator
  
  阿部眞一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
減数分裂誘導因子の研究
- Principal Investigator
  
  ABE Shinich
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Analysis of the mechanism underlying meiosis initiation using in vitro culture system.
- Principal Investigator
  
  ABE Shinich
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  Kumamoto University

[Book] 完全版　ゲノム編集実験スタンダード2019
- Author(s)
  山本　卓、佐久間哲史
- Total Pages
  386
- Publisher
  羊土社
- ISBN
  9784758122443
- Data Source
  KAKENHI-PROJECT-17H01409
[Book] ゲノム編集の基本原理と応用2018
- Author(s)
  山本　卓
- Total Pages
  176
- Publisher
  裳華房
- ISBN
  9784785358693
- Data Source
  KAKENHI-PROJECT-17H01409
[Book] ゲノム編集入門2016
- Author(s)
  山本　卓
- Total Pages
  20
- Publisher
  裳華房
- Data Source
  KAKENHI-PROJECT-26290070
[Journal Article] Activin is superior to BMP7 for efficient maintenance of human iPSC-derived nephron progenitors.2019
- Author(s)
  Tanigawa S, Naganuma H, Kaku Y, Era T, Sakuma T, Yamamoto T, Taguchi A and Nishinakamura R.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 13 Pages: 322-337
- DOI
  10.1016/j.stemcr.2019.07.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06264, KAKENHI-PROJECT-19K08707, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-17H06177, KAKENHI-PROJECT-17H01409
[Journal Article] Single-molecule nanoscopy elucidates RNA Polymerase II transcription at single genes in live cells2019
- Author(s)
  Li Jieru、Dong Ankun、Saydaminova Kamola、Chang Hill、Wang Guanshi、Ochiai Hiroshi、Yamamoto Takashi、Pertsinidis Alexandros
- Journal Title
  
  Cell
  
  Volume: 178 Pages: 491-506
- DOI
  10.1016/j.cell.2019.05.029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06612, KAKENHI-PROJECT-17H01409
[Journal Article] CRISPR-Cas3 induces broad and unidirectional genome editing in human cells2019
- Author(s)
  Morisaka Hiroyuki、Yoshimi Kazuto、Okuzaki Yuya、Gee Peter、Kunihiro Yayoi、Sonpho Ekasit、Xu Huaigeng、Sasakawa Noriko、Naito Yuki、Nakada Shinichiro、Yamamoto Takashi、Sano Shigetoshi、Hotta Akitsu、Takeda Junji、Mashimo Tomoji
- Journal Title
  
  Nature communications
  
  Volume: 10 Pages: 5302-5302
- DOI
  10.1038/s41467-019-13226-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16025, KAKENHI-PROJECT-17H01409, KAKENHI-PROJECT-18H03974
[Journal Article] Anephrogenic phenotype induced by SALL1 gene knockout in pigs2019
- Author(s)
  Watanabe M, Nakano K, Uchikura A, Matsunari H, Yashima S, Umeyama K, Takayanagi S, Sakuma T, Yamamoto T, Morita S, Horii T, Hatada I, Nishinakamura R, Nakauchi H, Nagashima H.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 8016-8016
- DOI
  10.1038/s41598-019-44387-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06607, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-17H01409
[Journal Article] Microhomology-assisted scarless genome editing in human iPSCs2018
- Author(s)
  Kim Shin-Il、Matsumoto Tomoko、Kagawa Harunobu、Nakamura Michiko、Hirohata Ryoko、Ueno Ayano、Ohishi Maki、Sakuma Tetsushi、Soga Tomoyoshi、Yamamoto Takashi、Woltjen Knut
- Journal Title
  
  Nat Commun
  
  Volume: 9 Pages: 939-939
- DOI
  10.1038/s41467-018-03044-y
- NAID
  120006406848
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07256, KAKENHI-PROJECT-17H01409, KAKENHI-PROJECT-16K18478
[Journal Article] Three-Component Repurposed Technology for Enhanced Expression: Highly Accumulable Transcriptional Activators via Branched Tag Arrays2018
- Author(s)
  Kunii A, Hara Y, Takenaga M, Hattori N, Fukazawa T, Ushijima T, Yamamoto T, Sakuma T.
- Journal Title
  
  CRISPR J
  
  Volume: 1 Pages: 337-347
- DOI
  10.1089/crispr.2018.0009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01409
[Journal Article] Biased genome editing using the local accumulation of DSB repair molecules system2018
- Author(s)
  Nakade S, Mochida K, Kunii A, Nakamae K, Aida T, Tanaka K, Sakamoto N, Sakuma T, Yamamoto T
- Journal Title
  
  Nat Commun
  
  Volume: 9(1) Pages: 1-10
- DOI
  10.1038/s41467-018-05773-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07241, KAKENHI-PROJECT-18K19494, KAKENHI-PROJECT-17H01409, KAKENHI-PROJECT-17H02216, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-17K15045
[Journal Article] PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation.2017
- Author(s)
  Miyamoto Tatsuo、Akutsu Silvia Natsuko、Fukumitsu Akihiro、Morino Hiroyuki、Masatsuna Yoshinori、Hosoba Kosuke、Kawakami Hideshi、Yamamoto Takashi、Shimizu Kenji、Ohashi Hirofumi、Matsuura Shinya
- Journal Title
  
  Hum Mol Genet
  
  Volume: 26 Pages: 4429-4440
- DOI
  10.1093/hmg/ddx330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26242085, KAKENHI-PROJECT-15H04321, KAKENHI-PROJECT-15K15017, KAKENHI-PROJECT-15K15083
[Journal Article] Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice.2017
- Author(s)
  Nakagawa Y, Sakuma T, Nishimichi N, Yokosaki Y, Takeo T, Nakagata N, Yamamoto T
- Journal Title
  
  Boil Open
  
  Volume: - Pages: 706-713
- DOI
  10.1242/bio.025122
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-17K11242, KAKENHI-PROJECT-15H04606, KAKENHI-PROJECT-15K07051, KAKENHI-PROJECT-17H04161
[Journal Article] Safety and efficacy of treatment with asfotase alfa in patients with hypophosphatasia: Results from a Japanese clinical trial2017
- Author(s)
  Kitaoka Taichi、Tajima Toshihiro、Nagasaki Keisuke、Kikuchi Toru、Yamamoto Katsusuke、Michigami Toshimi、Okada Satoshi、Fujiwara Ikuma、Kokaji Masayuki、Mochizuki Hiroshi、Ogata Tsutomu、Tatebayashi Koji、Watanabe Atsushi、Yatsuga Shuichi、Kubota Takuo、Ozono Keiichi
- Journal Title
  
  Clin Endocrinol.
  
  Volume: 87 Pages: 10-19
- DOI
  10.1111/cen.13343
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05355, KAKENHI-PROJECT-16K15528
[Journal Article] Establishment of expanded and streamlined pipeline of PITCh knock-in - a web-based design tool for MMEJ-mediated gene knock-in, PITCh designer, and the variations of PITCh, PITCh-TG and PITCh-KIKO2017
- Author(s)
  Nakamae K, Nishimura Y, Takenaga M, Nakade S, Sakamoto N, Ide H, Sakuma T, Yamamoto T
- Journal Title
  
  Bioengineered
  
  Volume: - Pages: 302-308
- DOI
  10.1080/21655979.2017.1313645
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-17H01409
[Journal Article] Rapid and efficient analysis of gene function using CRISPR-Cas9 in Xenopus tropicalis founders2016
- Author(s)
  Shigeta, Mitsuki; Sakane, Yuto; Iida, Midori; Suzuki, Miyuki; Kashiwagi, Keiko; Kashiwagi, Akihiko; Fujii, Satoshi; Yamamoto, Takashi; Suzuki, Ken-ichi
- Journal Title
  
  Genes to Cell
  
  Volume: in press Pages: 755-771
- DOI
  10.1111/gtc.12379
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15J05833, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008, KAKENHI-PROJECT-26290070
[Journal Article] Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice.2016
- Author(s)
  Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Noriyuki Yanaka, Toru Takeo, Naomi Nakagata and Takashi Yamamoto
- Journal Title
  
  Biol. Open
  
  Volume: 5 Pages: 1142-1148
- DOI
  10.1242/bio.019349
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04606, KAKENHI-PROJECT-26290070, KAKENHI-PROJECT-26293174, KAKENHI-PROJECT-26660112, KAKENHI-PROJECT-15K07051, KAKENHI-PROJECT-16K18478
[Journal Article] ene cassette knock-in mammalian cells and zygotes by enhanced MMEJ.2016
- Author(s)
  Aida T, Nakade S, Sakuma T, Izu Y, Oishi A, Mochida K, Ishikubo H, Usami T, Aizawa H, Yamamoto T, Tanaka K.
- Journal Title
  
  GMC Genomics
  
  Volume: 17 Pages: 979-979
- DOI
  10.1186/s12864-016-3331-9
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01383, KAKENHI-PLANNED-26112010, KAKENHI-PROJECT-16J03164, KAKENHI-PROJECT-26290021, KAKENHI-PROJECT-26290070, KAKENHI-PROJECT-26430008, KAKENHI-PROJECT-15K19988, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-16K18478
[Journal Article] MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems2016
- Author(s)
  Sakuma T, Nakade S, Sakane Y, Suzuki K, Yamamoto T.
- Journal Title
  
  Nature Protocols
  
  Volume: 11 Pages: 118-113
- DOI
  10.1038/nprot.2015.140
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06802, KAKENHI-PROJECT-26290070
[Journal Article] Production of knockout mice by DNA microinjection of various CRISPR/Cas9 vectors into freeze-thawed fertilized oocytes.2015
- Author(s)
  Nakagawa Y, Sakuma T, Sakamoto T, Ohmuraya M, Nakagata N, Yamamoto T
- Journal Title
  
  BMC Biotechnology
  
  Volume: - Pages: 33-33
- DOI
  10.1186/s12896-015-0144-x
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-26111516, KAKENHI-PROJECT-15H04606
[Journal Article] The Expression of TALEN before Fertilization Provides a Rapid Knock-out Phenotype in Xenopus laevis Founder Embryos2015
- Author(s)
  Miyamoto K, Suzuki K, Suzuki M, Sakane Y, Sakuma T, Herberg S, Simeone A, Simpson D, Jullien J, Yamamoto T, Gurdon JB.
- Journal Title
  
  PLoS One
  
  Volume: 10(11)
- DOI
  10.1371/journal.pone.0142946
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06802, KAKENHI-PROJECT-15J05833, KAKENHI-PROJECT-26290070
[Journal Article] Homologous recombination-independent large gene cassette knock-in in CHO cells using TALEN and MMEJ-directed donor plasmid2015
- Author(s)
  Sakuma, T., Takenaga, M., Kawabe, Y., Nakamura, T., Kamihira, M. & Yamamoto, T.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 16 Pages: 23849-23866
- DOI
  10.3390/ijms161023849
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-26117718, KAKENHI-PROJECT-25292219, KAKENHI-PROJECT-26290070
[Journal Article] Unliganded thyroid hormone receptor α regulates developmental timing via gene repression in Xenopus tropicalis2015
- Author(s)
  J. Choi, K. T. Suzuki, T. Sakuma, L. Shewade, T. Yamamoto and D. R. Buchholz
- Journal Title
  
  Endocrinology
  
  Volume: 156 Pages: 735-44
- DOI
  10.1210/en.2014-1554
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
[Journal Article] Targeted mutagenesis of multiple and paralogous genes in Xenopus laevis using two pairs of TALENs2014
- Author(s)
  Sakane, Y., Sakuma, T., Kashiwagi, K., Kashiwagi, A., Yamamoto, T. and Suzuki, K. T.
- Journal Title
  
  Dev Growth Differ.
  
  Volume: 56(1) Pages: 108-114
- DOI
  10.1111/dgd.12105
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-21221004, KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-24657156, KAKENHI-PUBLICLY-25124708, KAKENHI-PROJECT-25890014
[Journal Article] Imaging plant leaves to determine changes in radioactive contamination status in Fukushima, Japan.2014
- Author(s)
  Maruyama H, Yasui T, Ishikawa-Fujiwara T, Morii E, Yamamoto Y, Yoshii T, Takenaka Y, Nakahara S, Todo T, Hongyo T, Inohara H.
- Journal Title
  
  Cancer Science
  
  Volume: 105(4) Pages: 409-417
- DOI
  10.1111/cas.12369
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23241023, KAKENHI-PROJECT-24241018, KAKENHI-PROJECT-24651048, KAKENHI-PROJECT-25220102, KAKENHI-PROJECT-25281019, KAKENHI-PROJECT-25550029
[Journal Article] TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome2014
- Author(s)
  Ochiai H, Miyamoto T, Kanai A, Hosoba K, Sakuma T, Kudo Y, Asami K, Ogawa A, Watanabe A, Kajii T, Yamamoto T, Matsuura S.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 111(4) Pages: 1461-1466
- DOI
  10.1073/pnas.1317008111
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23710068, KAKENHI-PROJECT-24310043, KAKENHI-PROJECT-24651222, KAKENHI-PROJECT-24657156, KAKENHI-PUBLICLY-25113521, KAKENHI-PROJECT-25830138, KAKENHI-PROJECT-25890014
[Journal Article] Tissue-specific and ubiquitous gene knockouts by TALEN electroporation provide new approaches to investigating gene function in Ciona.2014
- Author(s)
  Treen, N., Yoshida, K., Sakuma, T., Sasaki, H., Kawai, N., Yamamoto, T., Sasakura, Y.
- Journal Title
  
  Development
  
  Volume: 141 Pages: 481-487
- DOI
  10.1242/dev.099572
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-21112004, KAKENHI-PROJECT-23681039, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
[Journal Article] Versatile strategy for isolating TALEN-mediated knockout mutants in Caenorhabditis elegans2014
- Author(s)
  Sugi T, Sakuma T, Ohtani T and Yamamoto T
- Journal Title
  
  Development, Growth and Differentiation
  
  Volume: 56 Pages: 78-85
- DOI
  10.1111/dgd.12108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25840124, KAKENHI-PROJECT-25890014
[Journal Article] Germ cell mutations of the ascidian Ciona intestinalis with TALE nucleases2014
- Author(s)
  Yoshida K, Treen N, Hozumi A, Sakuma T, Yamamoto T, Sasakura Y.
- Journal Title
  
  Genesis
  
  Volume: in press Pages: 431-439
- DOI
  10.1002/dvg.22770
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-21112004, KAKENHI-PROJECT-23681039, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
[Journal Article] TALEN-induced gene knock out in Drosophila2014
- Author(s)
  Kondo T
- Journal Title
  
  Dev Growth Differ
  
  Volume: 56:1 Pages: 86-91
- DOI
  10.1111/dgd.12097
- NAID
  40019949320
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22111007, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
[Journal Article] Targeted mutagenesis in sea urchin embryos using TALENs2014
- Author(s)
  Hosoi S, Sakuma T, Sakamoto N and Yamamoto T
- Journal Title
  
  Dev Growth Differ
  
  Volume: 56 Pages: 92-97
- DOI
  10.1111/dgd.12099
- NAID
  40019949329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
[Journal Article] Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9.2014
- Author(s)
  S. Nakade, T. Tsubota, Y. Sakane, S. Kume, N. Sakamoto, M. Obara, T. Daimon, H. Sezutsu, T. Yamamoto, T. Sakuma and K. T. Suzuki
- Journal Title
  
  Nature communications
  
  Volume: 5 Pages: 5560-5560
- DOI
  10.1038/ncomms6560
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-23688008, KAKENHI-PUBLICLY-25124708, KAKENHI-PROJECT-25292202, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26290070
[Journal Article] Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity2014
- Author(s)
  Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T
- Journal Title
  
  Sci Rep
  
  Volume: 3 Pages: 33379-33379
- DOI
  10.1038/srep03379
- NAID
  120005349008
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-23710068, KAKENHI-PROJECT-24310043, KAKENHI-PROJECT-24651222, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-24700427, KAKENHI-PUBLICLY-25113521, KAKENHI-PUBLICLY-25124708, KAKENHI-PROJECT-25890014
[Journal Article] TALENs efficiently disrupt the target gene in Iberian ribbed newts (Pleurodeles waltl), an experimental model animal for regeneration2014
- Author(s)
  Hayashi T, Sakamoto K, Sakuma T, Yokotani N, Inoue T, Kawaguchi E, Agata K, Yamamoto T, Takeuchi T
- Journal Title
  
  Dev. Growth Differ.,
  
  Volume: 56 Pages: 115-121
- DOI
  10.1111/dgd.12103
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22124001, KAKENHI-PLANNED-22124002, KAKENHI-PROJECT-24657155, KAKENHI-PROJECT-24657156, KAKENHI-PUBLICLY-25113520, KAKENHI-PUBLICLY-25124706, KAKENHI-PROJECT-25840086, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26650082
[Journal Article] Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by TALEN and CRISPR/Cas systems2014
- Author(s)
  A. Yasue, S. N. Mitsui, T. Watanabe, T. Sakuma, S. Oyadomari, T. Yamamoto, S. Noji, T. Mito and E. Tanaka
- Journal Title
  
  Scientific Repots
  
  Volume: 4 Pages: 1-10
- DOI
  10.1038/srep05705
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-25463184, KAKENHI-PROJECT-25650080, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26293436, KAKENHI-PROJECT-26670270, KAKENHI-PROJECT-26870415
[Journal Article] roduction of Sry knockout mouse using TALEN via oocyte injection.2013
- Author(s)
  Kato T, Miyata K, Sonobe M, Yamashita S, Tamano M, Miura K, Kanai Y, Miyamoto S, Sakuma T, Yamamoto T, Inui M, Kikusui T, Asahara H, Takada S.
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Pages: 3136-3136
- DOI
  10.1038/srep03136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570265, KAKENHI-PUBLICLY-24115707, KAKENHI-PROJECT-24228005, KAKENHI-PROJECT-24657156, KAKENHI-PLANNED-25118007, KAKENHI-PUBLICLY-25132713, KAKENHI-PROJECT-25890014
[Journal Article] Efficient TALEN construction and evaluation methods for human ceel and animal applications2013
- Author(s)
  Sakuma T, Hosoi S, Woltjen K, Suzuki KI, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T.
- Journal Title
  
  Gene Cells
  
  Volume: (In press) Pages: 315-326
- DOI
  10.1111/gtc.12037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J02843, KAKENHI-PROJECT-12J06938, KAKENHI-PLANNED-21112004, KAKENHI-PLANNED-22111007, KAKENHI-PROJECT-23710068, KAKENHI-PROJECT-23710240, KAKENHI-PROJECT-24310043, KAKENHI-PROJECT-24651222, KAKENHI-PROJECT-24657156
[Journal Article] Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes.2013
- Author(s)
  Tomoji Mashimo
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Pages: 1253-1253
- DOI
  10.1038/srep01253
- NAID
  120005241415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06938, KAKENHI-PROJECT-21680037, KAKENHI-PROJECT-24310041, KAKENHI-PROJECT-24700427
[Journal Article] Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells2013
- Author(s)
  Hiramoto T
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 110 Pages: 3023-3028
- DOI
  10.1073/pnas.1217039110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591161, KAKENHI-PROJECT-23310137, KAKENHI-PROJECT-23650150, KAKENHI-PROJECT-23790126, KAKENHI-PROJECT-24390257, KAKENHI-PROJECT-24390272, KAKENHI-PROJECT-24659489, KAKENHI-PROJECT-25293231, KAKENHI-PLANNED-23106004
[Journal Article] Nucleosome exclusion from the interspecies conserved central AT-rich region of the Arsinsulater2012
- Author(s)
  Takagi H, Inai Watanabe SI, Tatemoto S, Yajima M, Akasaka K, Yamamoto T, SakamotoN
- Journal Title
  
  J. Biochem
  
  Volume: 151(1) Pages: 78-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570226
[Journal Article] HpSumf1 is involved in the activation of sulafatases responsible for regulation of skeletogenesisduring sea urchin development2011
- Author(s)
  Sakuma T, Ohnishi K, Fujita K, Ochia H, Sakamoto N, Yamamoto T.
- Journal Title
  
  Development Genes and Evolution
  
  Volume: 221(3) Pages: 157-166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570226
[Journal Article] Mammalian arlysulfatase A functions as a novel component of the extracellular-matrix.2010
- Author(s)
  Fujita K, Teramura N, Hattori S, Irie S, Mitsunaga-Nakatsubo K, Akimoto T, Sakamoto N, Yamamoto T, Akasaka K.
- Journal Title
  
  Connective Tissue Research 51(5)
  
  Pages: 388-396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200006
[Journal Article] Dicer is required for the normal development of sea urchin, Hemicentrotus pulcherrimus.2010
- Author(s)
  Okamitsu Y, Yamamoto T, Fujii, T., Ochiai, H.and Sakamoto, N.
- Journal Title
  
  Zoological Science 27(6)
  
  Pages: 477-486
- NAID
  40017358605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200006
[Journal Article] Dicer is required for the normalde velopment of sea urchin2010
- Author(s)
  Okamitsu Y, Yamamoto T, Fujii T, Ochiai H, Sakamoto N
- Journal Title
  
  Hemicentrotus pulcherrimus. Zoological Science
  
  Volume: 27 Pages: 477-486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570226
[Journal Article] Targeted mutagenesis in the sea urchin embryo using zinc-finger nucleases.2010
- Author(s)
  Ochiai H, Fujita K, Suzuki K, Nishikawa M, Shibata T, Sakamoto N, Yamamoto T.
- Journal Title
  
  Genes to Cells 15(8)
  
  Pages: 875-885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200006
[Journal Article] Targeted mutagenesis in the sea urchin embryo usingzinc-finger nucleases2010
- Author(s)
  Ochiai H, Fujita K, Suzuki K, Nishikawa M, Shibata T, Sakamoto N, Yamamoto T.
- Journal Title
  
  Genes to Cells
  
  Volume: 15 Pages: 875-885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570226
[Journal Article] Implication of HpEts in gene regulatory networks responsible for specification of seaurchin sleletogenic primary me senchyme cells2010
- Author(s)
  Yajima M, Umeda R, Fuchikami T, Kataoka M, Sakamoto N, Yamamoto T, Akasaka K.
- Journal Title
  
  Zoological Science
  
  Volume: 27 Pages: 638-646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570226
[Journal Article] HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development.2010
- Author(s)
  Fujita K, Takechi E, Sakamoto N, Sumiyoshi N, Izumi S, Miyamoto T, Matsuura, S, Akasaka K, Yamamoto T.
- Journal Title
  
  Mechanisms of Development 127(3-4)
  
  Pages: 235-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200006
[Journal Article] Implication of HpEts in gene regulatory networks responsible for specification of sea urchin skeletogenic primary mesenchyme cells.2010
- Author(s)
  Yajima M, Umeda R, Fuchikami T, Kataoka M, Sakamoto N, Yamamoto T, Akasaka K.
- Journal Title
  
  Zoological Science 27(8)
  
  Pages: 638-646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200006
[Journal Article] Mammalian arylsulfatase A functions as a novel component of the extracellular matrix2010
- Author(s)
  Fujita K, Teramura N, Hattori S, Irie S, Mitsunaga-Nakatsubo K, Akimoto Y, SakamotoN, Yamamoto T, Akasaka K.
- Journal Title
  
  Connective Tissue Research
  
  Volume: 51 Pages: 388-396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570226
[Journal Article] Role of the nanos homolog during sea urchin development2009
- Author(s)
  Fujii T, Sakamoto N, Ochiai H, Fujita K, Okamitsu Y, Sumiyoshi N, Minokawa T, Yamamoto T.
- Journal Title
  
  Developmental Dynamics
  
  Volume: 238 Pages: 2511-2521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570226
[Journal Article] HpSulf, a heparin sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during seaurchin development2009
- Author(s)
  Fujita K, Takechi E, Sakamoto N, SumiyoshiN, Izumi S, Miyamoto T, Matsuura S, Tsurugaya T, Akasaka K, Yamamoto T.
- Journal Title
  
  Mechanisms of Development
  
  Volume: 127 Pages: 235-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570226
[Journal Article] Role of the nanos homolog during sea urchin development.2009
- Author(s)
  Fujii T, Sakamoto N, Ochiai H, Fujita K, Okamitsu Y, Sumiyoshi N, Minokawa T, Yamamoto T.
- Journal Title
  
  Developmental Dynamics 238(10)
  
  Pages: 2511-2521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200006
[Journal Article] Suppressor of hairless(Su(H)) is required for foregut development in the sea urchin embryo2009
- Author(s)
  Karasawa K, Sakamoto N, Fujita K, Ochiai H, Fujii T, Akasaka K, Yamamoto T.
- Journal Title
  
  Zoological Science
  
  Volume: 26 Pages: 686-690
- NAID
  40016807049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570226
[Journal Article] Suppressor of Hairless (Su(H)) is required for foregut development in the sea urchin embryo.2009
- Author(s)
  Karasawa K, Sakamoto N, Fujita K, Ochiai H, Fujii T, Akasaka K, Yamamoto T.
- Journal Title
  
  Zoological Science 26(10)
  
  Pages: 686-690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200006
[Journal Article] The Ars insulator facilitates I-SceI meganuclease-mediated transgenesis in the sea urchin embryo.2008
- Author(s)
  Ochiai H, Sakamoto N, Suzuki K, Akasaka K, Yamamoto T.
- Journal Title
  
  Developmental Dynamics 237(9)
  
  Pages: 2475-2482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200006
[Journal Article] Analysis of cis-regulatory elements controlling spatiotemporal expression of T-brain gene in sea urchin2008
- Author(s)
  Ochiai H, Sakamoto N, Momiyama A, Akasaka K, Yamamoto T.
- Journal Title
  
  Hemicentrotus pulcherrimus.Mechanisms of Development 125(1-2)
  
  Pages: 2-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200006
[Journal Article] RSF Governs Silent Chromatin Formation via Histone H2Av Replacement.2008
- Author(s)
  Hanai K, Furuhashi H, Yamamoto T, Akasaka K, Hirose S
- Journal Title
  
  PLoS genetics 4(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200006
[Journal Article] DNA variations within the sea urchin Otx enhancer.2007
- Author(s)
  Yamamoto T.
- Journal Title
  
  FEBS letters 581・27
  
  Pages: 5234-5240
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17570179
[Journal Article] DNA variations within the sea urchin Otx enhancer2007
- Author(s)
  Yamamoto, T
- Journal Title
  
  FEBS Letters 581(27)
  
  Pages: 5234-5240
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570179
[Journal Article] DNA variations within the sea urchin Otx enhancer.2007
- Author(s)
  Yamamoto T., et. al.
- Journal Title
  
  FEBS letters 581・27
  
  Pages: 5234-5240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17570179
[Journal Article] Sexually dimorphic expression of a teleost homologue of Mulleria inhibiting substance during gonadal sex differentiationin Japanease flounder, Paralichthys olivaceus.2004
- Author(s)
  Yoshinaga N, Shiraishi E, Yamamoto T, Iguchi Y, Abe SI.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 322
  
  Pages: 508-513
- Data Source
  KAKENHI-PROJECT-16027235
[Journal Article] The Otx binding site is required for the activation of HpOLxL mRNA expression in the sea urchin, Hemlcentrotus pulcherrlmus.2004
- Author(s)
  Hayashibara Y, Nakatsubo K, Sakamoto N, Shimotori T, Akasaka K, Yamamoto T.
- Journal Title
  
  Dev.Growth & Differ. 46
  
  Pages: 61-67
- Data Source
  KAKENHI-PROJECT-16027235
[Journal Article] A new G-stretch-DNA-binding protein, Unichrom, displays cell-cycle-dependent expression in sea urchin embryos.2004
- Author(s)
  Moritani K, Tagashira H, Shimotori T, Sakamoto N, Tanaka S, Yamamoto T, Akasaka K
- Journal Title
  
  Dev.Growth & Differ. 46
  
  Pages: 335-341
- NAID
  10013585223
- Data Source
  KAKENHI-PROJECT-16027235
[Journal Article] Identification of two teleost homologs of the Drosophila sex determination factor, transformer-2 in medaka (Oryzias latipes).2004
- Author(s)
  Shiraishi E, Imazato H, Yamamoto T, Yokoi H, Abe S, Kitano T.
- Journal Title
  
  Mechanisms of Development 121
  
  Pages: 991-996
- Data Source
  KAKENHI-PROJECT-16027235
[Patent] 標的遺伝子にエフェクタータンパク質を集積するための組成物、およびその利用2018
- Inventor(s)
  山本卓、佐久間哲史、國井厚志
- Industrial Property Rights Holder
  山本卓、佐久間哲史、國井厚志
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17H01409
[Patent] 核酸挿入用ベクター2013
- Inventor(s)
  鈴木賢一、坂根祐人、佐久間哲史、山本卓
- Industrial Property Rights Holder
  鈴木賢一、坂根祐人、佐久間哲史、山本卓
- Industrial Property Rights Type
  特許
- Filing Date
  2013-11-06
- Data Source
  KAKENHI-PROJECT-24657156
[Patent] 新規DNA結合ドメインおよびそれを含む新規DNA切断酵素2011
- Inventor(s)
  山本卓
- Industrial Property Rights Holder
  山本卓
- Filing Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21570226
[Patent] 新規DNA結合ドメインおよびそれを含む新規DNA切断酵素2011
- Inventor(s)
  山本卓・坂本尚昭・佐久間哲史・野地澄晴
- Industrial Property Rights Holder
  広島大学
- Industrial Property Number
  2011-242250
- Filing Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21570226
[Presentation] Applications of Genome Editing Technology for Various Life Science Research2019
- Author(s)
  Yamamoto T
- Organizer
  GWG 2019 Genome Engineering Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01409
[Presentation] Basics of genome editing and biased genome editing using the LoAD system in cultured cells and organisms2018
- Author(s)
  Yamamoto T
- Organizer
  Functional Genomics and Structural Biology (FGSB)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01409
[Presentation] CRISPR-Casシステムを用いたノックインマウス作製における凍結受精卵培養時間の検討2017
- Author(s)
  中川佳子、佐久間哲史、西道教尚、横崎恭之、若松和子、春口幸恵、近藤朋子、竹下由美、中牟田裕子、石田恵理、坂本亘、土山修治、竹尾　透、山本　卓、中潟直己
- Organizer
  第64回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] ゲノム編集技術の基本原理と医学研究での利用2017
- Author(s)
  山本　卓
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台
- Year and Date
  2017-03-07
- Invited
- Data Source
  KAKENHI-PROJECT-26290070
[Presentation] Advances in genome editing technology and its applications in biomedical fields2017
- Author(s)
  Takashi Yamamoto
- Organizer
  The 23rd Annual Meeting of Japan Society of Gene and Cell Therapy
- Invited
- Data Source
  KAKENHI-PROJECT-17H01409
[Presentation] ゲノム編集技術を用いた鎖骨頭蓋異形成症モデルマウスの作成2017
- Author(s)
  吉本由紀、森　健吾、星野　麻里、田中　誠真、渡邊　仁美、佐久間　哲史、山下　寛、岡本　哲治、近藤　玄、山本　卓、開　祐司、宿南　知佐
- Organizer
  日本ゲノム編集学会第2回大会
- Data Source
  KAKENHI-PROJECT-16K15780
[Presentation] メダカにおけるrev3l変異体の紫外線誘発突然変異と消化管腫瘍の解析2017
- Author(s)
  藤川芳宏、藤原智子、佐藤鮎子、佐久間哲史、山本卓、辻村亨、藤堂剛
- Organizer
  日本環境変異原学会
- Data Source
  KAKENHI-PROJECT-25220102
[Presentation] CRISPR-Casシステムを用いたノックインマウス作製における凍結受精卵培養時間の検討2017
- Author(s)
  中川佳子、佐久間哲史、西道教尚、横崎恭之、竹尾透、山本卓、中潟直己
- Organizer
  第2回日本ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] CRISPR-Cas9の再生医療での可能性2017
- Author(s)
  山本　卓
- Organizer
  第２回再生医療産学官連携シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H01409
[Presentation] Culture time of zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice2017
- Author(s)
  Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Toru Takeo, Naomi Nakagata, and Takashi Yamamoto
- Organizer
  2nd annual Genome Editing & Engineering Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] CRISPR-Casシステムを用いたノックインマウス作製における凍結受精卵培養時間の検討2017
- Author(s)
  中川佳子、佐久間哲史、西道教尚、横崎泰之、近藤朋子、竹下由美、中牟田裕子、石田恵理、坂本亘、土山修治、竹尾　透、山本　卓、中潟直己
- Organizer
  第35回動物生殖工学研究会
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] メダカ Rev3L 変異体の紫外線および放射線感受性の解析2016
- Author(s)
  藤川芳宏、藤原(石川) 智子、佐久間哲史、山本卓、藤堂剛
- Organizer
  第38回　光医学・光生物学会
- Place of Presentation
  京都リサーチパークサイエンスホール（京都市）
- Data Source
  KAKENHI-PROJECT-25220102
[Presentation] Targeted inactivation of rev3l in medaka (Oryzias latipes)2016
- Author(s)
  Fujikawa Y,Ishikawa-Fujiwara T,Sakuma T, Yamamoto T, Tsujimura T, Todo T
- Organizer
  Oryzias latipes 10th 3R International Symposium
- Place of Presentation
  Hotel Ichibata（松江市）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220102
[Presentation] CRISPR-Casシステムによる様々なゲノム編集個体の作製―超過剰排卵誘起法を用いた体外受精凍結卵の利用2016
- Author(s)
  中川佳子，佐久間哲史，西道教尚，横崎恭之，矢中規之，竹尾透，中潟直己，山本卓
- Organizer
  第一回ゲノム編集学会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] ニワトリ始原生殖細胞への効果的なゲノム編集2016
- Author(s)
  中川祐樹, 江﨑僚, 廣瀬文哉, 古澤修一，佐久間哲史, 黒岩麻里, 山本卓, 堀内浩幸
- Organizer
  第1回日本ゲノム編集学会
- Place of Presentation
  広島市
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-25292193
[Presentation] Rev3L変異体メダカの放射線および紫外線感受性の解析2016
- Author(s)
  藤川芳宏、藤原(石川) 智子、佐久間哲史、山本卓、藤堂剛
- Organizer
  日本放射線影響学会　第59回大会
- Place of Presentation
  JMSアステールプラザ(広島市)
- Data Source
  KAKENHI-PROJECT-25220102
[Presentation] CRISPR-Casシステムによるfloxマウスの作製－超過剰排卵誘起法を用いた凍結受精卵の利用－2016
- Author(s)
  中川佳子、佐久間哲史、矢中規之、山本卓、若松和子、山下紀代子、春口幸恵、近藤朋子、竹下由美、中牟田裕子、梅野智子、土山修治、竹尾　透、中潟直己
- Organizer
  第50回日本実験動物技術者協会総会
- Place of Presentation
  ウェスタ川越（埼玉県川越市）
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] ゲノム編集の基本原理と最近の研究動向2016
- Author(s)
  山本　卓
- Organizer
  日本学術会議公開学術講演会「ゲノム編集技術の技術と将来展望」
- Place of Presentation
  東京
- Year and Date
  2016-08-19
- Invited
- Data Source
  KAKENHI-PROJECT-26290070
[Presentation] ゲノム編集の基本原理と研究動向2016
- Author(s)
  山本　卓
- Organizer
  JBAセミナー「ゲノム編集技術の最近の動向と規制・特許について」
- Place of Presentation
  東京
- Year and Date
  2016-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-26290070
[Presentation] ゲノム編集の基本原理と医学分野での利用2016
- Author(s)
  山本　卓
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-26290070
[Presentation] CRISPR-Casシステムによる遺伝子破壊マウスの作製－超過剰排卵誘起法を用いた凍結受精卵の利用－2016
- Author(s)
  中川佳子、佐久間哲史、坂本拓弥、山本卓、若松和子、山下紀代子、春口幸恵、近藤朋子、竹下由美、中牟田裕子、梅野智子、宮川あい、土山修治、竹尾透、中潟直己
- Organizer
  第63回日本実験動物学会
- Place of Presentation
  ミューザ川崎シンフォニーホール（神奈川県川崎市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] 凍結受精卵を用いたCRISPR/Cas9システムによる遺伝子破壊マウスの作製2015
- Author(s)
  中川佳子、佐久間哲史、坂本拓弥、大村谷昌樹、山本卓、中潟直己
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] ゲノム編集が生命科学に革命を起こす2015
- Author(s)
  山本　卓
- Organizer
  読売テクノフォーラム
- Place of Presentation
  東京
- Year and Date
  2015-06-22
- Invited
- Data Source
  KAKENHI-PROJECT-26290070
[Presentation] ゲノム編集の基本原理と医学分野での可能性2015
- Author(s)
  山本　卓
- Organizer
  日本人類遺伝学会第60回大会
- Place of Presentation
  東京
- Year and Date
  2015-10-16
- Invited
- Data Source
  KAKENHI-PROJECT-26290070
[Presentation] Study on male sex determination gene in the bird using genome editing technology2015
- Author(s)
  Yuki Nakagawa, Ryo Ezaki, Tetsushi Sakuma, Asato Kuroiwa, Takashi Yamamoto, Hiroyuki Horiuchi
- Organizer
  Biochemistry and Molecular Biology 2015
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25292193
[Presentation] Construction of optimized CRISPR/Cas system to research the anhydrobiosis in the sleeping chironomid2014
- Author(s)
  Okada J, Kikuta S, Gusev O, Suetugu Y, Cornette R, Yamamoto T, Kikawada T
- Organizer
  New Frontiers in Anhydrobiosis
- Place of Presentation
  ポミシェ、フランス
- Data Source
  KAKENHI-PROJECT-25252060
[Presentation] A high efficient gene targeting in one-cell mouse embryos mediated by TALEN and CRISPR/Cas system2014
- Author(s)
  Akihiro Yasue, Silvia Naomi Mitsui, Takahito Watanabe, Tetsushi Sakuma, Seiichi Oyadomari, Takashi Yamamoto, Sumihare Noji, Taro Mito, Eiji Tanaka
- Organizer
  International Symposium on RNAi and Genome Editing Research
- Place of Presentation
  徳島県（徳島大学）
- Invited
- Data Source
  KAKENHI-PROJECT-25463184
[Presentation] TALエフェクターヌクレアーゼ（TALENs）を用いたノックアウトラット作製技術2013
- Author(s)
  金子武人、佐久間哲史、山本卓、芹川忠夫、真下知士
- Organizer
  第60回日本実験動物学会総会
- Place of Presentation
  つくば国際会議場（つくば市）
- Data Source
  KAKENHI-PROJECT-24700427
[Presentation] TALエフェクターヌクレアーゼ(TALENs)を用いたノックアウトラット作製技術2013
- Author(s)
  金子武人、佐久間哲史、山本卓、芹川忠夫、真下知士
- Organizer
  第60回日本実験動物学会総会
- Place of Presentation
  つくば国際会議場、茨城県
- Data Source
  KAKENHI-PROJECT-24700427
[Presentation] ネムリユスリカの乾燥耐性遺伝子検索のためのゲノム編集技術の構築2013
- Author(s)
  岡田淳, 菊田真吾, Gusev O, 末次克行, Cornette R, 山本卓, 黄川田隆洋
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25252060
[Presentation] TALEN、CRISPR/Cas systemを用いたマウス１細胞期胚における標的遺伝子破壊2013
- Author(s)
  Akihiro Yasue, Silvia Naomi Mitsui, Takahito Watanabe, Tetsushi Sakuma, Seiichi Oyadomari, Takashi Yamamoto, Sumihare Noji, Taro Mito, Eiji Tanaka
- Organizer
  日本分子生物学会
- Place of Presentation
  兵庫県神戸市（神戸国際会議場）
- Data Source
  KAKENHI-PROJECT-25463184
[Presentation] ラットにおける遺伝子改変技術の新展開2013
- Author(s)
  芹川忠夫、金子武人、佐久間哲史、山本卓、真下知士
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場、福岡県
- Data Source
  KAKENHI-PROJECT-24700427
[Presentation] ZFN法とTALEN法を用いたゲノム編集時代の到来2012
- Author(s)
  山本卓
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-24657156
[Presentation] 人工ヌクレアーゼを基盤とする動物におけるゲノム編集2012
- Author(s)
  山本卓
- Organizer
  日本学術会議公開シンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24657156
[Presentation] Targeted insertion of reporter gene by zinc-finger nuclease mediated homologous recombination enables quantitative imaging of endogenous gene expression inliving sea urchin embryo2012
- Author(s)
  Yamamoto Takashi
- Organizer
  CDB symposium 2012 Quantitative biology
- Place of Presentation
  神戸
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21570226
[Presentation] Targeted insertion of reporter gene by zinc-finger nuclease mediated homologous recombination enables quantitative imaging of endogenous gene expression in living sea urchin embryo2012
- Author(s)
  Yamamoto T.
- Organizer
  CDB symposium 2012 Quantitative biology
- Place of Presentation
  神戸
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21570226
[Presentation] 人工ヌクレアーゼTALENによるノックアウトラットの作製2012
- Author(s)
  真下知士、金子武人、国広弥生、佐久間哲史、山本卓、芹川忠夫
- Organizer
  日本実験動物科学・技術九州2012
- Place of Presentation
  別府国際コンベンションセンター、大分県
- Data Source
  KAKENHI-PROJECT-24700427
[Presentation] ラットにおける遺伝子改変技術の新展開2012
- Author(s)
  芹川忠夫、金子武人、佐久間哲史、山本卓、真下知士
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡県）
- Invited
- Data Source
  KAKENHI-PROJECT-24700427
[Presentation] 人工ヌクレアーゼ（ZFNやTALEN）を用いたゲノム編集研究の現状と可能性2012
- Author(s)
  山本卓
- Organizer
  第5回DNA鑑定学会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24657156
[Presentation] Genome editing using artificial nucleases2012
- Author(s)
  Yamamoto T.
- Organizer
  The 2^<nd> International Conference on the Cricket
- Place of Presentation
  徳島
- Year and Date
  2012-03-22
- Data Source
  KAKENHI-PROJECT-21570226
[Presentation] Efficient gene targeting by TAL effector nucleases in rats2012
- Author(s)
  Tomoji Mashimo, Takehito Kaneko, Tetsushi Sakuma, Yayoi Kunihiro, Birger Voigt, Takashi Yamamoto, Tadao Serikawa
- Organizer
  Rat Genome and Models
- Place of Presentation
  ケンブリッジ（イギリス）
- Data Source
  KAKENHI-PROJECT-24700427
[Presentation] Efficient gene targeting by TAL effector nucleases in rats2012
- Author(s)
  Tomoji Mashimo, Takehito Kaneko, Tetsushi Sakuma, Yayoi Kunihiro, Birger Voigt, Takashi Yamamoto, Tadao Serikawa
- Organizer
  Rat Genome and Models, A Welcome Trust Scientific Conference
- Place of Presentation
  Cambridge, UK
- Data Source
  KAKENHI-PROJECT-24700427
[Presentation] 人工ヌクレアーゼTALENによるノックアウトラットの作製2012
- Author(s)
  真下知士、金子武人、国広弥生、佐久間哲史、山本卓、芹川忠夫
- Organizer
  日本実験動物科学・技術九州2012
- Place of Presentation
  別府国際コンベンションセンター（大分県）
- Data Source
  KAKENHI-PROJECT-24700427
[Presentation] Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes.2012
- Author(s)
  Tomoji Mashimo, Takehito Kaneko, Tetsushi Sakuma, Junya Kobayashi, Yayoi Kunihiro, Birger Voigt, Takashi Yamamoto, Tadao Serikawa
- Organizer
  Rat Genome and Models
- Place of Presentation
  ケンブリッジ（イギリス）
- Data Source
  KAKENHI-PROJECT-24700427
[Presentation] Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes2012
- Author(s)
  Tomoji Mashimo, Takehito Kaneko, Tetsushi Sakuma, Junya Kobayashi, Yayoi Kunihiro, Birger Voigt, Takashi Yamamoto, Tadao Serikawa
- Organizer
  Techniques and Procedures for Rat Gene Targeting, Reproduction, and Cryopreservation
- Place of Presentation
  Cambridge, UK
- Year and Date
  2012-12-03
- Data Source
  KAKENHI-PROJECT-24700427
[Presentation] Genome editing usingartificial nucleases2012
- Author(s)
  Yamamoto Takashi
- Organizer
  The 2^<nd> International Conference on the Cricket
- Place of Presentation
  徳島
- Year and Date
  2012-03-22
- Data Source
  KAKENHI-PROJECT-21570226
[Presentation] 人工ヌクレアーゼを基盤とした培養細胞および動物でのゲノム編集2012
- Author(s)
  山本卓
- Organizer
  日本動物学会第83回大会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-24657156
[Presentation] Targeted genemodification via non-homologous end-joining mediatedand homology-directed repairs ofZFN-induced DNA double-stranded breaks2011
- Author(s)
  Yamamoto Takashi
- Organizer
  1st international symposium on Genome damageand Non-cancerous diseased
- Place of Presentation
  Hiroshima
- Year and Date
  2011-03-03
- Data Source
  KAKENHI-PROJECT-21570226
[Presentation] 様々な生物での標的遺伝子改変を可能にするゲノム編集技術とその可能性2011
- Author(s)
  山本卓
- Organizer
  日本発生生物学会秋季シンポジウム
- Place of Presentation
  岡崎(招待講演)
- Year and Date
  2011-12-19
- Data Source
  KAKENHI-PROJECT-21570226
[Presentation] 様々な生物での標的遺伝子改変を可能にするゲノム編集技術とその可能性2011
- Author(s)
  山本卓
- Organizer
  日本発生生物学会秋季シンポジウム
- Place of Presentation
  岡崎
- Year and Date
  2011-12-20
- Data Source
  KAKENHI-PROJECT-21570226
[Presentation] Targeted gene modification via viaon viaon vian viaation viaiaiaon viaaon viaahomologous end-joining-mediated and homology-directed repairs of ZFN-induced DNA double-stranded breaks2011
- Author(s)
  Yamamoto Takashi
- Organizer
  1st international symposium on Genome damage and Non -cancerous diseased
- Place of Presentation
  Hiroshima.
- Year and Date
  2011-03-03
- Data Source
  KAKENHI-PROJECT-20200006
[Presentation] 多細胞生物の発生過程における遺伝子発現のゆらぎ2009
- Author(s)
  山本卓
- Organizer
  数理生命科学の形成と発展
- Place of Presentation
  東広島
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-21570226
[Presentation] 多細胞生物の発生過程における遺伝子発現のゆらぎ2009
- Author(s)
  山本卓
- Organizer
  広島大学大学院理学研究科数理分子生命理学専攻シンポジウム・数理生命科学の形成と発展
- Place of Presentation
  東広島
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-20200006
[Presentation] 多細胞生物の発生過程における遺伝子発現のゆらぎ2009
- Author(s)
  山本卓
- Organizer
  数理生命科学の形成と発展
- Place of Presentation
  東広島
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-20200006
[Presentation] 多細胞生物の発生過程における遺伝子発現のゆらぎ2009
- Author(s)
  山本卓
- Organizer
  広島大学大学院理学研究科数理分子生命理学専攻シンポジウム・数理生命科学の形成と発展
- Place of Presentation
  東広島
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-21570226
[Presentation] Transcriptional regulation of T-brain gene (Tb) during sea urchin (Hemicentrotus pulcherrimus) development2006
- Author(s)
  Yamamoto, T
- Organizer
  20th IUBMB international congress of biochemistry and molecular biology
- Place of Presentation
  Kyoto
- Year and Date
  2006-06-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570179
[Presentation] Transcriptional regulation of T-brain gene(Tb)during sea urchin(Hemicentrotus pulcherrimus)development2006
- Author(s)
  Yamamoto, T.
- Organizer
  20th IUBMB international congress of Biochemistry and Molecular biology
- Place of Presentation
  Kyoto
- Year and Date
  2006-06-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570179
[Presentation] Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by TALEN and CRISPR/Cas systems.
- Author(s)
  Yasue A, Mitsui SN, Watanabe T, Sakuma T, Oyadomari S, Yamamoto T, Noji S, Mito T, Tanaka E
- Organizer
  The X meeting for Spanish Society for Developmental Biology (SEBD)
- Place of Presentation
  Madrid (Spain)
- Year and Date
  2014-10-13 – 2014-10-15
- Data Source
  KAKENHI-PROJECT-25463184
[Presentation] ネムリユスリカの乾燥耐性遺伝子検索のためのゲノム編集技術の構築
- Author(s)
  岡田淳, 菊田真吾, Gusev O, 末次克行, Cornette R, 山本卓, 黄川田隆洋
- Organizer
  第59回低温生物工学会年会セミナー及び年会
- Place of Presentation
  九州大学
- Year and Date
  2014-06-28 – 2014-06-29
- Data Source
  KAKENHI-PROJECT-25252060
[Presentation] 人工多能性幹細胞における X 線に対する高感受性細胞死のp53依存的な誘導機構の解明
- Author(s)
  香川晴信，河合秀彦，佐久間哲史，山本卓，塩谷文章，嶋本顕，田原栄俊
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25670030
[Presentation] Platinum TALENの開発と様々な動物におけるゲノム編集
- Author(s)
  山本卓
- Organizer
  理研シンポジウム「ゲノムデザイン技術と疾患モデル研究」
- Place of Presentation
  つくば
- Invited
- Data Source
  KAKENHI-PROJECT-24657156
[Presentation] MMEJ-mediated integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9
- Author(s)
  Nakade S, Tsubota T, Sakane Y, Kume S, Sakamoto N, Obara M, Daimon T, Sezutsu H, Yamamoto T, Sakuma T and Suzuki KI
- Organizer
  Keystone Sympsia
- Place of Presentation
  Big Sky, MT, USA
- Year and Date
  2015-01-11 – 2015-01-16
- Data Source
  KAKENHI-PROJECT-26290070
[Presentation] Genome editing in cultured cells and animals using TALENs and CRISPR/Cas
- Author(s)
  Yamamoto T
- Organizer
  The 3rd “International Institute for Advanced Studies” Conference of Novel Developments on the Study of Life and Biological Systems Based on Genome Engineering and Imaging Science
- Place of Presentation
  木津川市
- Year and Date
  2014-10-28 – 2014-10-29
- Invited
- Data Source
  KAKENHI-PROJECT-26290070
[Presentation] p53-GFPノックインマウス作製の試み
- Author(s)
  関原和正、佐久間哲史、山本卓、野田朝男
- Organizer
  日本放射線影響学会第５７回大会
- Place of Presentation
  かごしま県民交流センター（鹿児島市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-25220102
[Presentation] 人工ヌクレアーゼを用いた両生類でのゲノム編集
- Author(s)
  山本卓
- Organizer
  日本動物学会第84回大会シンポジウム「生物実験材料としてのネッタイツメガエルの長所と有用性」
- Place of Presentation
  岡山
- Invited
- Data Source
  KAKENHI-PROJECT-24657156
[Presentation] 高活性型TALENの開発と哺乳類培養細胞および動物での標的遺伝子改変
- Author(s)
  山本卓
- Organizer
  第65回日本生物工学会シンポジウム「次世代の植物バイオテクノロジー」
- Place of Presentation
  広島
- Invited
- Data Source
  KAKENHI-PROJECT-24657156
[Presentation] TALENsによるメダカにおけるTLSポリメラーゼ遺伝子群変異体の網羅的作製
- Author(s)
  藤川芳宏、藤原（石川）智子、佐久間哲史、山本卓、藤堂剛
- Organizer
  日本放射線影響学会第５７回大会
- Place of Presentation
  かごしま県民交流センター（鹿児島市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-25220102
[Presentation] CRISPR/CasシステムによるPax6遺伝子破壊マウスの解析
- Author(s)
  河野仁美、泰江章博、石丸善康、井上順治、渡辺崇仁、板東哲哉、親泊政一、野地澄晴、三戸太郎、山本卓、田中栄二、大内淑代
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25463184
[Presentation] ゲノム編集技術による乾燥耐性遺伝子検索のためのツール構築
- Author(s)
  岡田淳, 菊田真吾, Gusev O, 末次克行, Cornette R, 山本卓, 黄川田隆洋
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25252060
[Presentation] Genome editing using Platinum TALENs
- Author(s)
  Sakuma T, Suzuki KI and Yamamoto T
- Organizer
  FASEB Science Research Conference
- Place of Presentation
  Nassau, Bahamas
- Year and Date
  2014-06-22 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-24657156
[Presentation] ゲノム編集革命ー人工ヌクレアーゼを利用した遺伝子改変技術の開発
- Author(s)
  山本卓
- Organizer
  平成25年度広島バイオフォーラム「ここまで進んだゲノム科学とその活用」
- Place of Presentation
  広島
- Invited
- Data Source
  KAKENHI-PROJECT-24657156
[Presentation] ゲノム編集技術の限りない可能性
- Author(s)
  山本卓
- Organizer
  染色体工学研究センター研究成果発表会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24657156
[Presentation] ゲノム編集技術を用いた鳥類性決定関連遺伝子の解析
- Author(s)
  枡岡久子，中川祐樹，江崎僚，佐久間哲史，黒岩麻里，山本卓，堀内浩幸
- Organizer
  第４回ゲノム編集研究会
- Place of Presentation
  広島市（広島国際会議場）
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25292193

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Yamamoto Takashi 山本 卓

YAMAMOTO Takashi 山本 卓

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Morphological characteristics of the genome stress-induced chromosomal tether structureOngoing

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Development of genome editing platform technology for various disease modelsPrincipal InvestigatorOngoing

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Development of a novel genome editing-mediated gene knock-in systemPrincipal Investigator

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Development of universal method for genome modification using zinc finger nucleasePrincipal Investigator

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Yamamoto Takashi 山本卓

YAMAMOTO Takashi 山本卓