YASUDA TOMOHARU 保田朋波流

… Alternative Names

Researcher Number	40334429
Other IDs
Affiliation (Current)	2022: 広島大学, 医系科学研究科(医), 教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 広島大学, 医系科学研究科(医), 教授 2017 – 2018: 九州大学, 生体防御医学研究所, 准教授 2009: 理研, 研究員 2008: The Institute of Physical and Chemical Research, 分化制御研究グループ, 研究員 2007: The Institute of Physical and Chemical Research, 分化制御研究グループ, 研究員 2006: 独立行政法人理化学研究所, 分化制御研究グループ, 研究員 2001 – 2004: 東京医科歯科大学, 難治疾患研究所, 助手
Review Section/Research Field	Principal Investigator Immunology / Basic Section 49070:Immunology-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields Except Principal Investigator Biological Sciences
Keywords	Principal Investigator B細胞 / リンパ腫 / 免疫応答 / 細胞分裂 / 細胞老化 / 体細胞変異 / 抗体 / BLNK / アダプター分子 / BCR … More Except Principal Investigator シグナル伝達 / 蛋白質 / 造血細胞 / チロシンキナーゼ / 免疫学 / 増殖異常 / アダプター / 癌 / Ras-Erk / アダプター分子 / EBウイルス Less

Epigenetic regulation of lymphocyte cell division and oncogenesisPrincipal Investigator
- Principal Investigator
  
  保田朋波流
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Hiroshima University
Whole-life tracing and cell-cell regulation in B cellsPrincipal Investigator
- Principal Investigator
  
  YASUDA TOMOHARU
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Hiroshima University
Regulation of lymphocyte cell division and oncogenesisPrincipal Investigator
- Principal Investigator
  
  YASUDA TOMOHARU
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Hiroshima University
  Kyushu University
Molecular mechanisms limiting cell division in cancer and immunityPrincipal Investigator
- Principal Investigator
  
  保田朋波流
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Kyushu University
T細胞依存性抗原に対するB細胞応答におけるErkの役割の解明Principal Investigator
- Principal Investigator
  
  保田朋波流
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
BCR下流のアダプター分子BLNKと会合する新規シグナル分子の機能解析Principal Investigator
- Principal Investigator
  
  保田朋波流
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
蛋白質チロシンリン酸化と癌細胞の増殖応答
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
免疫シグナル伝達におけるrasGAP結合蛋白質Dok及びDok-2の機能解析
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University

All 2021 2020 2019 2018 2017 2008 2007 2004

All Journal Article Presentation

[Journal Article] A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK82021
- Author(s)
  Sakurai Tetsuya、Kukimoto-Niino Mutsuko、Kunimura Kazufumi、Yamane Nana、Sakata Daiji、Aihara Ryosuke、Yasuda Tomoharu、Yokoyama Shigeyuki、Shirouzu Mikako、Fukui Yoshinori、Uruno Takehito
- Journal Title
  
  Life Science Alliance
  
  Volume: 4
- DOI
  10.26508/lsa.202000873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06575, KAKENHI-PROJECT-18H02669, KAKENHI-PROJECT-19K22538
[Journal Article] Pathologically Relevant Mouse Models for Epstein-Barr Virus-Associated B Cell Lymphoma2021
- Author(s)
  Huang Shiyu、Yasuda Tomoharu
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12
- DOI
  10.3389/fimmu.2021.639844
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02669, KAKENHI-PROJECT-19K22538
[Journal Article] Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells2021
- Author(s)
  Yasuda T, Saito Y, Ono C, Kawata K, Baba A, Baba Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Pages: 5524-5524
- DOI
  10.1038/s41598-021-84786-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02626, KAKENHI-PROJECT-18H02669, KAKENHI-PROJECT-19K22537, KAKENHI-PROJECT-19K22538
[Journal Article] Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis2020
- Author(s)
  Sommermann Thomas、Yasuda Tomoharu、Ronen Jonathan、Wirtz Tristan、Weber Timm、Sack Ulrike、Caeser Rebecca、Zhang Jingwei、Li Xun、Chu Van Trung、Jauch Anna、Unger Kristian、Hodson Daniel J.、Akalin Altuna、Rajewsky Klaus
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Pages: 14421-14432
- DOI
  10.1073/pnas.1921139117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02669, KAKENHI-PROJECT-19K22538
[Journal Article] Measuring Protein Synthesis during Cell Cycle by Azidohomoalanine (AHA) Labeling and Flow Cytometric Analysis.2019
- Author(s)
  Imami, K., Yasuda T.
- Journal Title
  
  Bio-protocol
  
  Volume: 9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02669
[Journal Article] Measuring Protein Synthesis during Cell Cycle by Azidohomoalanine (AHA) Labeling and Flow Cytometric Analysis2019
- Author(s)
  Imami K, Yasuda T.
- Journal Title
  
  BIO-PROTOCOL
  
  Volume: １ Pages: 1-7
- DOI
  10.21769/bioprotoc.3215
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22538, KAKENHI-PROJECT-18H02669, KAKENHI-PROJECT-18K14674
[Journal Article] Phosphorylation of the ribosomal protein RPL12/uL11 affects translation during Mitosis.2018
- Author(s)
  Imami Koshi、Milek Miha、Bogdanow Boris、Yasuda Tomoharu、Kastelic Nicolai、Zauber Henrik、Ishihama Yasushi、Landthaler Markus、Selbach Matthias
- Journal Title
  
  Mol. Cell
  
  Volume: 72 Pages: 84-98
- DOI
  10.1016/j.molcel.2018.08.019
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14674, KAKENHI-PROJECT-18H02669
[Journal Article] Erk Kinases link pre-BCR signaling to transcriptional events required for early B cell expansion.2008
- Author(s)
  Yasuda, T., et. al.
- Journal Title
  
  Immunity (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790348
[Journal Article] Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia.2004
- Author(s)
  Tomoharu Yasuda 他
- Journal Title
  
  The Journal of Experimental Medicine 200
  
  Pages: 1681-1687
- Data Source
  KAKENHI-PROJECT-14028021
[Presentation] B cell division in the heterogeneous pre-tumor microenvironment is required for lymphoma development2020
- Author(s)
  Tomoharu Yasuda, Klaus Rajewsky
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] 抗原受容体と免疫寿命のコントロール2020
- Author(s)
  保田朋波流
- Organizer
  広島市医師会　第135回学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] B cell division in the heterogeneous pre-tumor microenvironment is required for lymphoma development2020
- Author(s)
  Tomoharu Yasuda, Klaus Rajewsky
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] 抗原受容体と免疫細胞の維持機構2020
- Author(s)
  保田朋波流
- Organizer
  第一三共消化器疾患セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] 抗原受容体と免疫寿命のコントロール2020
- Author(s)
  保田朋波流
- Organizer
  広島市医師会　第135回学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] 抗原受容体と免疫細胞の維持機構2020
- Author(s)
  保田朋波流
- Organizer
  第一三共消化器疾患セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] 抗原受容体シグナルとB細胞寿命2019
- Author(s)
  保田朋波流
- Organizer
  第46回広島大学健康長寿研究拠点HiHAセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] 広島市抗原受容体とB細胞寿命2019
- Author(s)
  保田朋波流
- Organizer
  第65回広島大学第二外科同門研修会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] EBV-LMP1による宿主抗原性転換と細胞傷害性T細胞分化2019
- Author(s)
  保田朋波流
- Organizer
  第１回感染に起因する腫瘍の共同研究セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] EBウイルスとヒト免疫系の共生/共進化2019
- Author(s)
  保田朋波流
- Organizer
  中国四国ウイルス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] EBV-LMP1による宿主抗原性転換と細胞傷害性T細胞分化2019
- Author(s)
  保田朋波流
- Organizer
  第１回感染に起因する腫瘍の共同研究セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] EBウイルスとヒト免疫系の共生／共進化2019
- Author(s)
  保田朋波流
- Organizer
  広島免疫学リサーチセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] 抗原受容体とB細胞寿命2019
- Author(s)
  保田朋波流
- Organizer
  第65回広島大学第二外科同門研修会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] EBウイルスとヒト免疫系の共生/共進化2019
- Author(s)
  保田朋波流
- Organizer
  中国四国ウイルス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] EBウイルスとヒト免疫系の共生／共進化2019
- Author(s)
  保田朋波流
- Organizer
  広島免疫学リサーチセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] 抗原受容体シグナルとB細胞寿命2019
- Author(s)
  保田朋波流
- Organizer
  第46回広島大学健康長寿研究拠点HiHAセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] Active B cell division on plasma cell niche is required for lymphoma development.2018
- Author(s)
  Yasuda, T., Baba, Y., and Rajewsky, K.
- Organizer
  The 13th International Symposium of the Institute Network for Biomedical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] Epstein-BarrウイルスによるB細胞リンパ腫発症とその免疫監視機構2017
- Author(s)
  保田朋波流
- Organizer
  第21回生物機能研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06937
[Presentation] Requirement for Erk1 and Erk2 MAP kinases in the early Bcell development2007
- Author(s)
  Yasuda, T.
- Organizer
  日本免疫学会
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-18790348

1. 山梨裕司 (40202387)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 樋口理 (50361720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 白形正樹 (70251551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. BABA Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 柊元睦子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 今見考志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

YASUDA TOMOHARU 保田 朋波流

保田 朋波流 ヤスダ トモハル

Research Projects

Research Products

Co-Researchers

Epigenetic regulation of lymphocyte cell division and oncogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Whole-life tracing and cell-cell regulation in B cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of lymphocyte cell division and oncogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms limiting cell division in cancer and immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

T細胞依存性抗原に対するB細胞応答におけるErkの役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

BCR下流のアダプター分子BLNKと会合する新規シグナル分子の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

蛋白質チロシンリン酸化と癌細胞の増殖応答

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫シグナル伝達におけるrasGAP結合蛋白質Dok及びDok-2の機能解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK82021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathologically Relevant Mouse Models for Epstein-Barr Virus-Associated B Cell Lymphoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Measuring Protein Synthesis during Cell Cycle by Azidohomoalanine (AHA) Labeling and Flow Cytometric Analysis.2019

Author(s)

Journal Title

Data Source

[Journal Article] Measuring Protein Synthesis during Cell Cycle by Azidohomoalanine (AHA) Labeling and Flow Cytometric Analysis2019

Author(s)

Journal Title

YASUDA TOMOHARU 保田朋波流

保田朋波流ヤスダトモハル

[Presentation] 広島市抗原受容体とB細胞寿命2019