YASUDA TOMOHARU 保田朋波流

… Alternative Names

保田朋波流ヤスダトモハル

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Researcher Number	40334429
Other IDs
Affiliation (Current)	2025: 広島大学, 医系科学研究科(医), 教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 広島大学, 医系科学研究科(医), 教授 2017 – 2018: 九州大学, 生体防御医学研究所, 准教授 2009: 理研, 研究員 2008: The Institute of Physical and Chemical Research, 分化制御研究グループ, 研究員 2007: The Institute of Physical and Chemical Research, 分化制御研究グループ, 研究員 2006: 独立行政法人理化学研究所, 分化制御研究グループ, 研究員 2001 – 2004: 東京医科歯科大学, 難治疾患研究所, 助手
Review Section/Research Field	Principal Investigator Immunology / Basic Section 49070:Immunology-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields Except Principal Investigator Biological Sciences / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 体細胞変異 / 免疫応答 / 細胞老化 / 細胞分裂 / リンパ腫 / B細胞 / T細胞 / 胚中心 / 抗体 / B細胞分化 … More / H3K27me3 / 細胞不死化 / T細胞分化 / 細胞増殖 / エピゲノム制御 / NKT細胞 / PRC2 / 細胞寿命 / 老化 / クローン選択 / 免疫寿命 / 免疫老化 / 発現制御 / 癌 / 免疫学 / 抗体産生細胞 / T細胞依存性抗原 / シグナル分子 / Erk / 細胞 / BCR / アダプター分子 / BLNK … More Except Principal Investigator EBウイルス / チロシンキナーゼ / 造血細胞 / 蛋白質 / シグナル伝達 / 抗体サブクラススイッチ / Breg細胞 / NK細胞 / 腫瘍関連糖鎖抗原 / フローサイトメトリー / 慢性活動性EBV病 / CAEBV / Latency / アダプター分子 / Ras-Erk / 癌 / アダプター / 増殖異常 / 免疫学 Less

Elucidation of Multimodal Immune Evasion Mechanisms Mediated by Tumor-Associated Glycans and Development of Novel Therapeutic Strategies
- Principal Investigator
  
  大段秀樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Hiroshima University
難治性EBウイルス関連疾患の新規感染細胞解析法による病態解明
- Principal Investigator
  
  石村匡崇
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyushu University
Epigenetic regulation of lymphocyte cell division and oncogenesisPrincipal Investigator
- Principal Investigator
  
  Yasuda Tomoharu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Hiroshima University
Whole-life tracing and cell-cell regulation in B cellsPrincipal Investigator
- Principal Investigator
  
  YASUDA TOMOHARU
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Hiroshima University
Regulation of lymphocyte cell division and oncogenesisPrincipal Investigator
- Principal Investigator
  
  YASUDA TOMOHARU
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Hiroshima University
  Kyushu University
Molecular mechanisms limiting cell division in cancer and immunityPrincipal Investigator
- Principal Investigator
  
  保田朋波流
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Kyushu University
T細胞依存性抗原に対するB細胞応答におけるErkの役割の解明Principal Investigator
- Principal Investigator
  
  保田朋波流
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
BCR下流のアダプター分子BLNKと会合する新規シグナル分子の機能解析Principal Investigator
- Principal Investigator
  
  保田朋波流
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
蛋白質チロシンリン酸化と癌細胞の増殖応答
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
免疫シグナル伝達におけるrasGAP結合蛋白質Dok及びDok-2の機能解析
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020 2019 2018 2017 2008 2007 2004

All Journal Article Presentation Book Patent

[Book] EBウイルス関連胃癌　改訂第2版, 「EBウイルス関連腫瘍における免疫治療」2022
- Author(s)
  田村結実, 保田朋波流
- Total Pages
  109
- Publisher
  診断と治療社
- ISBN
  9784787825698
- Data Source
  KAKENHI-PROJECT-21H02751
[Journal Article] Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis2024
- Author(s)
  Li Xun、Wirtz Tristan、Weber Timm、Lebedin Mikhail、Lowenstein Elijah D.、Sommermann Thomas、Zach Andreas、Yasuda Tomoharu、de la Rosa Kathrin、Chu Van Trung、Schulte Johannes H.、Muller Ingo、Kocks Christine、Rajewsky Klaus
- Journal Title
  
  Science Immunology
  
  Volume: 9 Issue: 92
- DOI
  10.1126/sciimmunol.adi0042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02751
[Journal Article] Regulation mechanisms of <scp>CARMA1</scp> ?Bcl10? <scp>MALT1</scp> complex assembly inferred from the analysis of <scp>TRAF6</scp> ‐deficient cells2023
- Author(s)
  Inoue Kentaro、Yasuda Tomoharu、Baba Yoshihiro、Yamamoto Tadashi、Kurosaki Tomohiro、Shinohara Hisaaki
- Journal Title
  
  Genes to Cells
  
  Volume: - Issue: 6 Pages: 411-421
- DOI
  10.1111/gtc.13022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08484, KAKENHI-PROJECT-22H00450, KAKENHI-PROJECT-21H02751
[Journal Article] Mouse models of human multiple myeloma subgroups2023
- Author(s)
  Winkler Wiebke、Farre Diaz Carlota、Blanc Eric、Napieczynska Hanna、Langner Patrick、Werner Marvin、Walter Barbara、Wollert-Wulf Brigitte、Yasuda Tomoharu、Heuser Arnd、Beule Dieter、Mathas Stephan、Anagnostopoulos Ioannis、Rosenwald Andreas、Rajewsky Klaus、Janz Martin
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 10
- DOI
  10.1073/pnas.2219439120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Journal Article] Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants2023
- Author(s)
  Kiyomi Shitaoka, Akifumi Higashiura, Yohei Kawano, Akima Yamamoto, Yoko Mizoguchi, Takao Hashiguchi , Norihisa Nishimichi, Shiyu Huang, Ayano Ito, Shun Ohki, Miyuki Kanda, Tomohiro Taniguchi, Rin Yoshizato, Hitoshi Azuma, Yasuo Kitajima, Yasuyuki Yokosaki, Satoshi Okada, Takemasa Sakaguchi, Tomoharu Yasuda
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1-14
- DOI
  10.1038/s42003-023-04782-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16372, KAKENHI-PLANNED-20H05773, KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-23K07835, KAKENHI-PROJECT-21K19720, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-21H02751
[Journal Article] A senolytic immunotoxin eliminates p16-positive T cells and ameliorates age-associated phenotypes of CD4+ T cells in a surface marker knock-in mouse2023
- Author(s)
  Sugiyama Yuma、Harada Tanenobu、Kamei Yuka、Yasuda Tomoharu、Mashimo Tomoji、Nishikimi Akihiko、Maruyama Mitsuo
- Journal Title
  
  Experimental Gerontology
  
  Volume: 174 Pages: 112130-112130
- DOI
  10.1016/j.exger.2023.112130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17820, KAKENHI-PROJECT-18KK0307, KAKENHI-PROJECT-23K24781, KAKENHI-PROJECT-21H02751
[Journal Article] How Should We Deal with Neoplastic Disease and Serious Infections Caused by Epstein-Barr Virus ?2023
- Author(s)
  Yoshiyama Hironori、Nanbo Asuka、Yasuda Tomoharu
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 11 Pages: 2889-2889
- DOI
  10.3390/cancers15112889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07054, KAKENHI-PROJECT-21H02751
[Journal Article] Vaccination with the Omicron spike RBD boosts broadly neutralizing antibody levels and confers sustained protection even after acquiring immunity to the original antigen2023
- Author(s)
  Hitoshi Azuma, Yohei Kawano, Kiyomi Shitaoka, Takahiro Kawahara, Ayano Ito, Akifumi Higashiura, Yasuo Kitajima, Shun Ohki, Tomoharu Yasuda
- Journal Title
  
  International Immunology
  
  Volume: 35 Issue: 4 Pages: 197-207
- DOI
  10.1093/intimm/dxac055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16372, KAKENHI-PROJECT-21H02751, KAKENHI-PROJECT-20H04078
[Journal Article] Concomitant Cytotoxic Effector Differentiation of CD4+ and CD8+ T Cells in Response to EBV-Infected B Cells2022
- Author(s)
  Tamura Yumi、Yamane Keita、Kawano Yohei、Bullinger Lars、Wirtz Tristan、Weber Timm、Sander Sandrine、Ohki Shun、Kitajima Yasuo、Okada Satoshi、Rajewsky Klaus、Yasuda Tomoharu
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 17 Pages: 4118-4118
- DOI
  10.3390/cancers14174118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751, KAKENHI-PROJECT-20H04078
[Journal Article] Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis.2022
- Author(s)
  Mise S#, Matsumoto A#*, Shimada K, Hosaka T, Takahashi M, Ichihara K, Shimizu H, Shiraishi C, Saito D, Suyama M, Yasuda T, Ide T, Izumi Y, Bamba T, Kimura-Someya T, Shirouzu M, Miyata H, Ikawa M, Nakayama KI*.
- Journal Title
  
  Nat. Commun.
  
  Volume: 13(1) Issue: 1 Pages: 1071-1071
- DOI
  10.1038/s41467-022-28677-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05167, KAKENHI-PROJECT-20K21397, KAKENHI-PROJECT-18H05215, KAKENHI-PLANNED-17H06304, KAKENHI-PROJECT-20J11940, KAKENHI-PROJECT-18K06157, KAKENHI-PROJECT-20K16107, KAKENHI-PROJECT-21K17856, KAKENHI-PROJECT-21H02751, KAKENHI-PROJECT-20K15101, KAKENHI-PLANNED-20H05928
[Journal Article] Potential role of inducible GPR3 expression under stimulated T cell conditions2022
- Author(s)
  Shiraki, H., Tanaka, S., Guo, Y., Harada, K., Hide, I, Yasuda, T. and Sakai, N
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 148 Issue: 3 Pages: 307-314
- DOI
  10.1016/j.jphs.2022.01.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03409, KAKENHI-PROJECT-21K06802, KAKENHI-PROJECT-21K07274, KAKENHI-PROJECT-21H02751
[Journal Article] Efficient Isolation of Lymphocytes and Myogenic Cells from the Tissue of Muscle Regeneration2022
- Author(s)
  Kitajima Yasuo、Tsukahara Ryoka、Nakamoto Shohei、Yasuda Tomoharu
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 11 Pages: 1754-1754
- DOI
  10.3390/cells11111754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02751, KAKENHI-PROJECT-20H04078
[Journal Article] A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK82021
- Author(s)
  Sakurai Tetsuya、Kukimoto-Niino Mutsuko、Kunimura Kazufumi、Yamane Nana、Sakata Daiji、Aihara Ryosuke、Yasuda Tomoharu、Yokoyama Shigeyuki、Shirouzu Mikako、Fukui Yoshinori、Uruno Takehito
- Journal Title
  
  Life Science Alliance
  
  Volume: 4 Issue: 4 Pages: e202000873-e202000873
- DOI
  10.26508/lsa.202000873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06575, KAKENHI-PROJECT-18H02669, KAKENHI-PROJECT-19K22538, KAKENHI-PROJECT-19H00983, KAKENHI-PROJECT-21H02751, KAKENHI-PROJECT-18H02406
[Journal Article] A ubiquitin-like protein encoded by the “noncoding” RNA TINCR promotes keratinocyte proliferation and wound healing2021
- Author(s)
  Nita Akihiro、Matsumoto Akinobu、Tang Ronghao、Shiraishi Chisa、Ichihara Kazuya、Saito Daisuke、Suyama Mikita、Yasuda Tomoharu、Tsuji Gaku、Furue Masutaka、Katayama Bumpei、Ozawa Toshiyuki、Murata Teruasa、Dainichi Teruki、Kabashima Kenji、Hatano Atsushi、Matsumoto Masaki、Nakayama Keiichi I.
- Journal Title
  
  PLOS Genetics
  
  Volume: 17 Issue: 8 Pages: 1009686-1009686
- DOI
  10.1371/journal.pgen.1009686
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05215, KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-21H02751, KAKENHI-PROJECT-21K08303, KAKENHI-PROJECT-20K21386, KAKENHI-PLANNED-20H05928
[Journal Article] Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells.2021
- Author(s)
  Yasuda T, Saito Y, Ono C, Kawata K, Baba A, Baba Y.
- Journal Title
  
  Sci. Rep.
  
  Volume: 11 Issue: 1 Pages: 5524-5524
- DOI
  10.1038/s41598-021-84786-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02626, KAKENHI-PROJECT-18H02669, KAKENHI-PROJECT-19K22537, KAKENHI-PROJECT-19K22538, KAKENHI-PROJECT-21H02751, KAKENHI-PROJECT-21H02753
[Journal Article] Pathologically Relevant Mouse Models for Epstein-Barr Virus-Associated B Cell Lymphoma2021
- Author(s)
  Huang Shiyu、Yasuda Tomoharu
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12
- DOI
  10.3389/fimmu.2021.639844
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02669, KAKENHI-PROJECT-19K22538
[Journal Article] Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis2020
- Author(s)
  Sommermann Thomas、Yasuda Tomoharu、Ronen Jonathan、Wirtz Tristan、Weber Timm、Sack Ulrike、Caeser Rebecca、Zhang Jingwei、Li Xun、Chu Van Trung、Jauch Anna、Unger Kristian、Hodson Daniel J.、Akalin Altuna、Rajewsky Klaus
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 25 Pages: 14421-14432
- DOI
  10.1073/pnas.1921139117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02669, KAKENHI-PROJECT-19K22538
[Journal Article] Measuring protein synthesis during cell cycle by Azidohomoalanine (AHA) labeling and flow cytometric analysis.2019
- Author(s)
  Imami K, Yasuda T.
- Journal Title
  
  Bio-Protocol
  
  Volume: １ Issue: 8 Pages: 1-7
- DOI
  10.21769/bioprotoc.3215
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22538, KAKENHI-PROJECT-18H02669, KAKENHI-PROJECT-18K14674
[Journal Article] Measuring Protein Synthesis during Cell Cycle by Azidohomoalanine (AHA) Labeling and Flow Cytometric Analysis.2019
- Author(s)
  Imami, K., Yasuda T.
- Journal Title
  
  Bio-protocol
  
  Volume: 9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02669
[Journal Article] Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis2018
- Author(s)
  Imami Koshi、Milek Miha、Bogdanow Boris、Yasuda Tomoharu、Kastelic Nicolai、Zauber Henrik、Ishihama Yasushi、Landthaler Markus、Selbach Matthias
- Journal Title
  
  Molecular Cell
  
  Volume: 72 Issue: 1 Pages: 84-98
- DOI
  10.1016/j.molcel.2018.08.019
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14674, KAKENHI-PROJECT-18H02669
[Journal Article] Erk Kinases link pre-BCR signaling to transcriptional events required for early B cell expansion.2008
- Author(s)
  Yasuda, T., et. al.
- Journal Title
  
  Immunity (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790348
[Journal Article] Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia.2004
- Author(s)
  Tomoharu Yasuda 他
- Journal Title
  
  The Journal of Experimental Medicine 200
  
  Pages: 1681-1687
- Data Source
  KAKENHI-PROJECT-14028021
[Patent] 抗SARS-CoV-2抗体及びその取得方法2021
- Inventor(s)
  保田朋波流・下岡清美・他4名
- Industrial Property Rights Holder
  広島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-118204
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] Acquisition of tumor-specific T cell immunity by wide-spread viral molecule2024
- Author(s)
  Keita Yamane, Yohei Kawano, Shun Ohki, Yuri Matsuoka, Rin Yoshizato, Yumi Tamura, Yasuo Kitajima, Ryoka Tsukahara, Tomoharu Yasuda
- Organizer
  The 52nd Annual Meeting of The Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 疾患関連バリアント特定のためのEBウイルスゲノム大規模解析による分類方法の検討2024
- Author(s)
  福島大誠, 大木駿, 吉里倫, 保田朋波流
- Organizer
  第32回EBV感染症研究会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] Immune Surveillance of Radiation-Induced Tumors Elicited by Latent Epstein-Barr Virus Oncogenes2024
- Author(s)
  Yuqi Jin, Yun Guo, Tomoharu Yasuda.
- Organizer
  The 52nd Annual Meeting of The Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] Large-scale comparative analysis of Epstein-Barr virus genome to unveil geography- and disease-associated variations2024
- Author(s)
  Taisei Fukushima, Shun Ohki, Rin Yoshizato, Tomoharu Yasuda.
- Organizer
  The 8th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] The characterization of cultured common lymphoid progenitor-derived monocytic cells (cCLP-M)2024
- Author(s)
  Yohei Kawano, Mizuki Moriyama, Shun Ohki, Yasuo Kitajima, Tomoharu Yasuda
- Organizer
  The 52nd Annual Meeting of The Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] Sequential exposure to different SARS-CoV-2 antigens induces broadly neutralizing antibodies in mice.2024
- Author(s)
  Hitoshi Azuma, Yohei Kawano, Akifumi Higashiura, Yasuo Kitajima, Shun Ohki, Tomoharu Yasuda
- Organizer
  The 52nd Annual Meeting of The Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] Immune Surveillance of Spontaneous Tumors Triggered by Latent Epstein-Barr Virus Infection2024
- Author(s)
  Yuqi Jin, Yun Guo, Megumi Sasatani, Kenji Kamiya, Tomoharu Yasuda.
- Organizer
  The 8th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] The role of Polycomb group gene Eed in invariant NKT cell development and liver protection2024
- Author(s)
  Yun Guo, Yohei Kawano, Masamoto Kanno, Tomoharu Yasuda
- Organizer
  The 52nd Annual Meeting of The Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] pstein-Barr ウイルス分子LMP1による固形がん免疫監視誘導と治療応用2023
- Author(s)
  山根慶大, 河野洋平, 松岡祐里, 吉里倫, 田村結美, 北嶋康雄, 保田朋波流
- Organizer
  第82回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 回復者由来SARS-CoV-2中和抗体-スパイクタンパク質複合体の単粒子解析2023
- Author(s)
  野間井智, 安楽佑樹, 山本旭麻, 東浦彰史, 下岡清美, 河野洋平, 喜多俊介, 橋口隆生, 保田朋波流, 坂口剛正, 前仲勝実
- Organizer
  生命分子科学研究会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] CAEBVに対する細胞表面抗原を標的とした治療法の開発2023
- Author(s)
  吉里倫, 山根慶大, 保田朋波流
- Organizer
  第31回EBV感染症研究会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 新型コロナウイルス広域中和抗体の構造生物学的研究2023
- Author(s)
  24.東浦彰史, 山本旭麻, 下岡清美, 河野洋平, 保田朋波流, 坂口剛正
- Organizer
  第36回インフルエンザ研究者交流の会シンポジウム
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 次世代シーケンスによるアナフィラキシー誘発性IgE抗体産生経路の可視化2023
- Author(s)
  大木駿, 河原隆浩, 河野洋平, 保田朋波流
- Organizer
  第46回日本分子生物学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] SARS-CoV-2スパイク蛋白質と広域中和抗体の複合体構造解析2023
- Author(s)
  山本旭麻, 東浦彰史, 下岡清美, 河野洋平, 喜多俊介, 安楽佑樹, 野間井智, 橋口隆生, 前仲勝実, 保田朋波流, 坂口剛正
- Organizer
  日本結晶学会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] SARS-CoV-2のNタンパク質を中心とした構造生物学研究2023
- Author(s)
  東浦彰史, 山本旭麻, 伊藤遼樹, 吉里倫, 保田朋波流, 坂口剛正
- Organizer
  日本結晶学会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] SARS CoV-2スパイク蛋白質と各種中和抗体の複合体構造解析より明らかとなった中和活性メカニズム2023
- Author(s)
  山本旭麻, 東浦彰史, 下岡清美, 河野洋平, 喜多俊介, 安楽佑樹, 橋口隆生, 前仲勝実, 保田朋波流, 坂口剛正
- Organizer
  第70回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 骨格筋再生におけるB細胞の役割解明2023
- Author(s)
  北嶋康雄, 塚原涼火, 河野洋平, 保田朋波流
- Organizer
  第46回日本分子生物学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 新型コロナウイルスに対する広域中和抗体2023
- Author(s)
  保田朋波流
- Organizer
  第20回日本免疫治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 大規模なEBV遺伝子配列の比較解析による地域・疾患関連変異の特定2023
- Author(s)
  福島大誠, 大木駿, 吉里倫, 保田朋波流
- Organizer
  第46回日本分子生物学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] Define The Direct Activation of Mycophenolate mofetil in Non-Hepatic Cells.2023
- Author(s)
  Yusei Ota, Yuki Fujii, Hirotaka Kanoh, Rina Okihara, Mika Sasaki, Aki Ogawa-Iio, Sei Kondo, Keita Yamane, Yumi Tamura, Hirotoshi Ochi, Miki Senda, Kari Kopra, Harri Harma, Toshiya Senda, Koh Takeuchi, Tomoharu Yasuda, Atsuo Sasaki
- Organizer
  The 46th Annual Meeting of the Molecular Biology Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 培養共通リンパ球系前駆細胞由来単球／マクロファージ(cCLP-M)の性状及び機能解析2023
- Author(s)
  河野洋平, 森山瑞月, 大木駿, 北嶋康雄, 保田朋波流
- Organizer
  第46回日本分子生物学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] Epstein-Barrウイルス分子LMP1による固形がん免疫原性上昇作用の解明2023
- Author(s)
  山根慶大, 河野洋平, 松岡祐里, 吉里倫, 田村結美, 北嶋康雄, 保田朋波流
- Organizer
  第43回阿蘇シンポジウム
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] Epstein-Barrウイルス分子LMP1を用いた固形がん特異的細胞傷害性T細胞の誘導2023
- Author(s)
  山根慶大, 河野洋平, 大木駿, 松岡祐里, 吉里倫, 田村結実, 北嶋康雄, 塚原涼火, 福島大誠, 保田朋波流
- Organizer
  第46回日本分子生物学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 抗腫瘍細胞傷害活性を有するCD4陽性T細胞の性状と制御機構2023
- Author(s)
  田村結実，山根慶大, 森萌花，河野洋平, 大木駿, 北嶋康雄, 保田朋波流
- Organizer
  第20回日本免疫治療学会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 骨格筋はCaMK2を介して運動負荷に適応する2023
- Author(s)
  塚原涼火, 北嶋康雄, 河野洋平, 保田朋波流
- Organizer
  第46回日本分子生物学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 骨格筋再生組織からのリンパ球および筋細胞の効率的な単離方法の確立2022
- Author(s)
  北嶋康雄、塚原涼火、河野洋平、保田朋波流
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] ゲノム縮約ライブラリーを対象にしたSNP検出におけるシーケンサー特異性の比較2022
- Author(s)
  大木駿、北ノ坊誠也、松本悠貴、赤司亜弥子、守田昌哉、保田朋波流
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] SARS-CoV-2構造タンパク質の構造生物学的研究2022
- Author(s)
  山本旭麻、東浦彰史、伊藤遼樹、上岡史生子、下岡清美、河野洋平、保田朋波流、坂口剛正
- Organizer
  日本結晶学会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] Efficient CRISPR/Cas9-mediated precise gene repair in T cells to treat EBV-triggered primary HLH in mice and human2022
- Author(s)
  Li, X., Wirtz, T., Weber, T., Lowenstein, E.D., Sommermann, T., Tran, N.T., Danner, E., Graf, R., Zach, A., Lebedin, M., Yasuda, T., Kocks, C., de la Rosa, K., Kuhn, R., Chu, V.T., and Rajewsky, K.
- Organizer
  International LIT Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] Concomitant cytotoxic effector differentiation of CD4+ and CD8+ T cells in response to EBV infected B cells.2022
- Author(s)
  Yumi Tamura, Keita Yamane, Moeka Mori, Yohei Kawano, Shun Ohki, Yasuo Kitajima, Tomoharu Yasuda.
- Organizer
  The 51st Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] マウスEBウイルス感染モデルでのCD4+T, CD8+T細胞の細胞傷害性分化の類似性2022
- Author(s)
  山根慶大, 河野洋平，大木駿, 保田朋波流
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] Polycomb group gene Eed is required for invariant NKT development and maturation.2022
- Author(s)
  郭芸, 菅野　雅元, 保田　朋波流
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] EBウイルス感染細胞により活性化されるヒト末梢血CD4 T細胞の解析2022
- Author(s)
  田村結実，森萌花，北嶋康雄，河野洋平，保田朋波流
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] ゲノム編集技術を用いた免疫原性制御によるがん免疫療法の開発2022
- Author(s)
  山根慶大, 河野洋平, 保田朋波流
- Organizer
  第7回日本ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 培養共通リンパ系前駆細胞由来ミエロイド系細胞(cCLP-M)の性状及び機能解析2022
- Author(s)
  河野洋平、森山瑞月、大木駿、北嶋康雄、保田朋波流
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] Properties and functional analysis of cultured common lymphoid progenitor-derived monocytic cells (cCLP-M).2022
- Author(s)
  Yohei Kawano, Mizuki Moriyama, Shun Ohki, Yasuo Kitajima, Tomoharu Yasuda.
- Organizer
  The 51th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] SARS CoV-2スパイク蛋白質と中和抗体の複合体構造解析2022
- Author(s)
  東浦彰史、下岡清美、河野洋平、山本旭麻、保田朋波流、坂口剛正
- Organizer
  第69回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 立体構造解析から明らかとなったSARS CoV-2中和抗体とスパイク蛋白質の相互作用様式2022
- Author(s)
  東浦彰史、下岡清美、河野洋平、山本旭麻、保田朋波流、坂口剛正
- Organizer
  第36回中四国ウイルス研究会
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 免疫グロブリンの構造と生理的役割2021
- Author(s)
  保田朋波流
- Organizer
  第 29 回日本組織適合性学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 感染症治療薬として期待される人工中和抗体2021
- Author(s)
  保田朋波流
- Organizer
  第72回コロイドおよび界面化学討論会「新型コロナ感染症対策とコロイド・界面化学」
- Invited
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 新型コロナウイルス感染症治療における中和抗体の活用2021
- Author(s)
  保田朋波流、下岡清美、河野洋平
- Organizer
  第12回日本RNAi研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02751
[Presentation] 抗原受容体と免疫寿命のコントロール2020
- Author(s)
  保田朋波流
- Organizer
  広島市医師会　第135回学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] 抗原受容体と免疫細胞の維持機構2020
- Author(s)
  保田朋波流
- Organizer
  第一三共消化器疾患セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] 抗原受容体と免疫細胞の維持機構2020
- Author(s)
  保田朋波流
- Organizer
  第一三共消化器疾患セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] 抗原受容体と免疫寿命のコントロール2020
- Author(s)
  保田朋波流
- Organizer
  広島市医師会　第135回学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] B cell division in the heterogeneous pre-tumor microenvironment is required for lymphoma development2020
- Author(s)
  Tomoharu Yasuda, Klaus Rajewsky
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] B cell division in the heterogeneous pre-tumor microenvironment is required for lymphoma development2020
- Author(s)
  Tomoharu Yasuda, Klaus Rajewsky
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] EBV-LMP1による宿主抗原性転換と細胞傷害性T細胞分化2019
- Author(s)
  保田朋波流
- Organizer
  第１回感染に起因する腫瘍の共同研究セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] EBウイルスとヒト免疫系の共生／共進化2019
- Author(s)
  保田朋波流
- Organizer
  広島免疫学リサーチセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] EBウイルスとヒト免疫系の共生／共進化2019
- Author(s)
  保田朋波流
- Organizer
  広島免疫学リサーチセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] 広島市抗原受容体とB細胞寿命2019
- Author(s)
  保田朋波流
- Organizer
  第65回広島大学第二外科同門研修会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] EBV-LMP1による宿主抗原性転換と細胞傷害性T細胞分化2019
- Author(s)
  保田朋波流
- Organizer
  第１回感染に起因する腫瘍の共同研究セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] 抗原受容体とB細胞寿命2019
- Author(s)
  保田朋波流
- Organizer
  第65回広島大学第二外科同門研修会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] EBウイルスとヒト免疫系の共生/共進化2019
- Author(s)
  保田朋波流
- Organizer
  中国四国ウイルス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] EBウイルスとヒト免疫系の共生/共進化2019
- Author(s)
  保田朋波流
- Organizer
  中国四国ウイルス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] 抗原受容体シグナルとB細胞寿命2019
- Author(s)
  保田朋波流
- Organizer
  第46回広島大学健康長寿研究拠点HiHAセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K22538
[Presentation] 抗原受容体シグナルとB細胞寿命2019
- Author(s)
  保田朋波流
- Organizer
  第46回広島大学健康長寿研究拠点HiHAセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] Active B cell division on plasma cell niche is required for lymphoma development.2018
- Author(s)
  Yasuda, T., Baba, Y., and Rajewsky, K.
- Organizer
  The 13th International Symposium of the Institute Network for Biomedical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02669
[Presentation] Epstein-BarrウイルスによるB細胞リンパ腫発症とその免疫監視機構2017
- Author(s)
  保田朋波流
- Organizer
  第21回生物機能研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06937
[Presentation] Requirement for Erk1 and Erk2 MAP kinases in the early Bcell development2007
- Author(s)
  Yasuda, T.
- Organizer
  日本免疫学会
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-18790348

1. 山梨裕司 (40202387)

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2. 樋口理 (50361720)

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3. 白形正樹 (70251551)

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4. 石村匡崇 (10448417)

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5. 園田素史 (00748006)

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6. 大段秀樹 (10363061)

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7. 大平真裕 (30397947)

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8. 田原裕之 (30423354)

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9. 小林剛 (50528007)

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10. 山本卓 (90244102)

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11. 田中友加 (90432666)

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12. BABA Yoshihiro

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13. TANAKA Shigeru

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14. HARADA Kana

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15. 篠原久明

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16. 和泉自泰

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17. 柊元睦子

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18. 今見考志

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19. 中山啓子

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20. 中山敬一

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21. 秀和泉

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22. 酒井規雄

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23. 下岡清美

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# of Collaborated Products: 2 results
24. 杉山悠真

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25. 吉山裕規

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YASUDA TOMOHARU 保田 朋波流

保田 朋波流 ヤスダ トモハル

Research Projects

Research Products

Co-Researchers

Elucidation of Multimodal Immune Evasion Mechanisms Mediated by Tumor-Associated Glycans and Development of Novel Therapeutic Strategies

Principal Investigator

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難治性EBウイルス関連疾患の新規感染細胞解析法による病態解明

Principal Investigator

Project Period (FY)

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Research Institution

Epigenetic regulation of lymphocyte cell division and oncogenesisPrincipal Investigator

Principal Investigator

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Review Section

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Whole-life tracing and cell-cell regulation in B cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Regulation of lymphocyte cell division and oncogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Molecular mechanisms limiting cell division in cancer and immunityPrincipal Investigator

Principal Investigator

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T細胞依存性抗原に対するB細胞応答におけるErkの役割の解明Principal Investigator

Principal Investigator

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Research Institution

BCR下流のアダプター分子BLNKと会合する新規シグナル分子の機能解析Principal Investigator

Principal Investigator

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Research Institution

蛋白質チロシンリン酸化と癌細胞の増殖応答

Principal Investigator

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Research Institution

免疫シグナル伝達におけるrasGAP結合蛋白質Dok及びDok-2の機能解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] EBウイルス関連胃癌 改訂第2版, 「EBウイルス関連腫瘍における免疫治療」2022

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[Journal Article] Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis2024

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Data Source

[Journal Article] Regulation mechanisms of <scp>CARMA1</scp> ?Bcl10? <scp>MALT1</scp> complex assembly inferred from the analysis of <scp>TRAF6</scp> ‐deficient cells2023

Author(s)

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DOI

YASUDA TOMOHARU 保田朋波流

保田朋波流ヤスダトモハル

[Book] EBウイルス関連胃癌　改訂第2版, 「EBウイルス関連腫瘍における免疫治療」2022