Ohshima Keiichi 大島啓一

… Alternative Names

OSHIMA Keiichi 大島啓一

大島敬一オオシマケイイチ

OHSHIMA Keiichi 大島啓一

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Researcher Number	10399587
Affiliation (Current)	2025: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2025: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 2016 – 2023: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 2015: 静岡県立静岡がんセンター, 研究所, 研究員 2013 – 2015: 静岡県立静岡がんセンター(研究所), その他部局等, その他 2013: 静岡県立静岡がんセンター(研究所), その他部局等, 主任研究員 … More 2012: 静岡県立静岡がんセンター, 研究所, 研究員 2011 – 2012: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 2010 – 2011: 静岡県立静岡がんセンター(研究所), 遺伝子診療研究部, 主任研究員 2008: 静岡県立静岡がんセンター, その他部局, 研究員 2008: 静岡県立静岡がんセンター, 遺伝子診療研究部, 研究員 2007: Shizuoka Cancer Center, Research Institute, Researcher 2005 – 2007: 静岡県立静岡がんセンター(研究所), 遺伝子診療研究部, 主任研究員 2006: 静岡県立静岡がんセンター(研究所), 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor diagnostics / Laboratory medicine / Biological pharmacy Except Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 腫瘍マーカー / プロテオミクス / セクレトーム / 培養上清 / オミックス解析 / ドライバー遺伝子 / 神経内分泌腫瘍 / トランスクリプトーム / エクソーム / プロテオーム … More / 培養細胞 / ELISA / プロホルモン変換酵素 / 質量分析 / マイクロアレイ / microRNA / エクソソーム / リン酸化 / プロテオーム解析 / 欠失 / 変異 / 肺がん / ゲノム不安定性 / EGFR / イレッサ … More Except Principal Investigator 外科 / 癌 / 胃癌 / 次世代シークエンサー / 免疫関連遺伝子 / 同一がん遺伝子内複数変異 / Tumor mutation burden / Signature contribution / 免疫チェックポイント阻害薬 / CTNNB1 / MUC16 / 同一がん遺伝子内の複数変異 / 肝細胞癌 / 術後化学療法 / バイオマーカー / 術前化学療法 / 補助療法 / 膵癌 / AI / 受容体チロシンキナーゼ / KIT / VUS / 分子標的治療 / がんゲノム医療 / 網羅的遺伝子発現解析 / 網羅的遺伝子変異解析 / 遺伝子変異 / 遺伝子発現 / マイクロアレイ / ゲノム / peritoneal dissemination / MMP-7 / 血管新生 / リンパ管新生 / 腹腔内遊離がん細胞 / VEGF-C / 腹膜中皮 / 腹膜播種 / whole exome sequencing / whole exam sequence / whole exome sequence / splicing variant / miRNA / メタボローム解析 / 種瘍マーカー / 転移 / 微小転移 / 腫瘍マーカー / 遺伝子 / 予後因子 / Gli / PTCH-1 / sHH / 細胞増殖 / 癌幹細胞 Less

空間解析を用いたGISTの発生・進展に関わる分子機構の解明Principal Investigator
- Principal Investigator
  
  大島啓一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shizuoka Cancer Center Research Institute
Biomarker research using two prospective studies on preoperative and postoperative adjuvant therapy for pancreatic cancer
- Principal Investigator
  
  上坂克彦
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Shizuoka Cancer Center Research Institute
Establishment of treatment strategy based on the clinical significance of multiple mutations in individual genes in hepatocellular carcinoma
- Principal Investigator
  
  OKAMURA Yukiyasu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nihon University
The development of a method to predict the function of variants of unknown significance that accumulate in cancer genome analysis for clinical application purposes
- Principal Investigator
  
  Serizawa Masakuni
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shizuoka Cancer Center Research Institute
Pan-cancer multi-omics analysis toward identification of novel diagnostic and therapeutic target molecules in neuroendocrine tumorsPrincipal Investigator
- Principal Investigator
  
  Ohshima Keiichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shizuoka Cancer Center Research Institute
Classification of gastric cancer by molecular profiling
- Principal Investigator
  
  Terashima Masanori
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shizuoka Cancer Center Research Institute
Molecular profiling of proprotein convertases toward identification of secreted pro-hormone precursor proteins as novel tumor markersPrincipal Investigator
- Principal Investigator
  
  Ohshima Keiichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Shizuoka Cancer Center Research Institute
Prediction of malignant phenotype using metabolome analysis in gastric cancer
- Principal Investigator
  
  Terashima Masanori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shizuoka Cancer Center Research Institute
Exosomal microRNAs as diagnostic biomarkers in metastatic gastric cancerPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Keiichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Shizuoka Cancer Center Research Institute
Development of predictive markers for metastasis in gastric cancer
- Principal Investigator
  
  TERASHIMA Masanori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shizuoka Cancer Center Research Institute
Significance of cancer stem cells on tumor development and progression of human gastric cancer
- Principal Investigator
  
  TERASHIMA Masanori
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shizuoka Cancer Center Research Institute
  Fukushima Medical University
癌の腹膜播種原因遺伝子の同定と新しい分子標的治療
- Principal Investigator
  
  KAWAMURA Taiichi, 米村豊
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shizuoka Cancer Center
イレッサ高感受性肺腫瘍細胞におけるEGFR遺伝子不安定性の探究Principal Investigator
- Principal Investigator
  
  大島啓一
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Shizuoka Cancer Center Research Institute

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Characterization of pancreatic cancer with ultra-low tumor mutational burden2023
- Author(s)
  Imamura Taisuke、Ashida Ryo、Ohshima Keiichi、Uesaka Katsuhiko、Sugiura Teiichi、Ohgi Katsuhisa、Yamada Mihoko、Otsuka Shimpei、Hatakeyama Keiichi、Nagashima Takeshi、Sugino Takashi、Urakami Kenichi、Akiyama Yasuto、Yamaguchi Ken
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 4359-4359
- DOI
  10.1038/s41598-023-31579-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08700
[Journal Article] Molecular profile of poorly cohesive gastric carcinoma with special reference to survival2023
- Author(s)
  Koseki Yusuke、Hatakeyama Keiichi、Terashima Masanori、Nagashima Takeshi、Urakami Kenichi、Ohshima Keiichi、Aizawa Daisuke、Sugino Takashi、Furukawa Kenichiro、Fujiya Keiichi、Tanizawa Yutaka、Bando Etsuro、Okamura Yukiyasu、Akiyama Yasuto、Yamaguchi Ken
- Journal Title
  
  Gastric Cancer
  
  Volume: 26 Issue: 4 Pages: 553-564
- DOI
  10.1007/s10120-023-01390-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08811
[Journal Article] Molecular genetic positioning of small intestine and papilla of Vater carcinomas including clinicopathological classification2023
- Author(s)
  Nakamura Masanori、Okamura Yukiyasu、Ohshima Keiichi、Sugiura Teiichi、Ashida Ryo、Ohgi Katsuhisa、Bando Etsuro、Fujiya Keiichi、Shiomi Akio、Kagawa Hiroyasu、Imamura Taisuke、et al.
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 10 Pages: 11491-11502
- DOI
  10.1002/cam4.5877
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08811
[Journal Article] Hepatocellular carcinoma after a sustained virological response by direct‐acting antivirals harbors TP53 inactivation2022
- Author(s)
  Imamura Taisuke、Okamura Yukiyasu、Ohshima Keiichi、Uesaka Katsuhiko、Sugiura Teiichi、Ito Takaaki、Yamamoto Yusuke、Ashida Ryo、Ohgi Katsuhisa、Otsuka Shimpei、Ohnami Sumiko、Nagashima Takeshi、Hatakeyama Keiichi、Kakuda Yuko、Sugino Takashi、Urakami Kenichi、Akiyama Yasuto、Yamaguchi Ken
- Journal Title
  
  Cancer Medicine
  
  Volume: 11 Issue: 8 Pages: 1769-1786
- DOI
  10.1002/cam4.4571
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08811
[Journal Article] Molecular characterization‐based multi‐omics analyses in primary liver cancer using the Japanese version of the genome atlas2022
- Author(s)
  Imamura Taisuke、Okamura Yukiyasu、Ohshima Keiichi、Uesaka Katsuhiko、Sugiura Teiichi、Yamamoto Yusuke、Ashida Ryo、Ohgi Katsuhisa、Nagashima Takeshi、Yamaguchi Ken
- Journal Title
  
  Journal of Hepato-Biliary-Pancreatic Sciences
  
  Volume: 30 Issue: 3 Pages: 269-282
- DOI
  10.1002/jhbp.1223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08811
[Journal Article] Overview and clinical significance of multiple mutations in individual genes in hepatocellular carcinoma2022
- Author(s)
  Imamura Taisuke、Okamura Yukiyasu、Ohshima Keiichi、Uesaka Katsuhiko、Sugiura Teiichi、Ito Takaaki、Yamamoto Yusuke、Ashida Ryo、Ohgi Katsuhisa、Otsuka Shimpei、Ohnami Sumiko、Nagashima Takeshi、Hatakeyama Keiichi、Sugino Takashi、Urakami Kenichi、Akiyama Yasuto、Yamaguchi Ken
- Journal Title
  
  BMC Cancer
  
  Volume: 22 Issue: 1 Pages: 1046-1046
- DOI
  10.1186/s12885-022-10143-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08811
[Journal Article] Japanese version of The Cancer Genome Atlas, JCGA, established using fresh frozen tumors obtained from 5143 cancer patients.2020
- Author(s)
  Nagashima T, Yamaguchi K, Terashima M, et al.
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 2 Pages: 687-699
- DOI
  10.1111/cas.14290
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-18K07343, KAKENHI-PROJECT-18K07957
[Journal Article] Aberrant expression of Wnt/β-catenin signaling pathway genes in aggressive malignant gastric gastrointestinal stromal tumors.2020
- Author(s)
  Fujiya K, Ohshima K, Kitagawa Y, Hatakeyama K, Nagashima T, Aizawa D, Sugino T, Urakami K, Yamaguchi K, Terashima M.
- Journal Title
  
  Eur J Surg Oncol.
  
  Volume: - Issue: 6 Pages: 1080-1087
- DOI
  10.1016/j.ejso.2020.02.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10523
[Journal Article] Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide images.2020
- Author(s)
  Ono A, Terada Y, Kawata T, Serizawa M, Isaka M, Kawabata T, Imai T, Mori K, Muramatsu K, Hayashi I, Kenmotsu H, Ohshima K, Urakami K, Nagashima T, Kusuhara M, Akiyama Y, Sugino T, Ohde Y, Yamaguchi K, Takahashi T.
- Journal Title
  
  Cancer Med.
  
  Volume: - Issue: 13 Pages: 4864-4875
- DOI
  10.1002/cam4.3107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07792, KAKENHI-PROJECT-17K07209
[Journal Article] Characterization of Tumour Mutation Burden in Patients With Non-Small Cell Lung Cancer and Interstitial Lung Disease2019
- Author(s)
  Kobayashi H, Serizawa M, Naito T, Konno H, Kojima H, Mizuno T, Isaka M, Endo M, Nagashima T, Kusuhara M, Urakami K, Ohshima K, Yamaguchi K, Ohde Y, Takahashi T.
- Journal Title
  
  Respirology
  
  Volume: - Issue: 8 Pages: 850-854
- DOI
  10.1111/resp.13726
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07792
[Journal Article] Driver gene alterations and activated signaling pathways toward malignant progression of gastrointestinal stromal tumors.2019
- Author(s)
  Ohshima K, Fujiya K, Nagashima T, Ohnami S, Hatakeyama K, Urakami K, Naruoka A, Watanabe Y, Moromizato S, Shimoda Y, Ohnami S, Serizawa M, Akiyama Y, Kusuhara M, Mochizuki T, Sugino T, Shiomi A, Tsubosa Y, Uesaka K, Terashima M, Yamaguchi K.
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 12 Pages: 3821-3833
- DOI
  10.1111/cas.14202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-17K07209
[Journal Article] Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors.2017
- Author(s)
  Ohshima K, Hatakeyama K, Nagashima T, Watanabe Y, Kanto K, Doi Y, Ide T, Shimoda Y, Tanabe T, Ohnami S, Ohnami S, Serizawa M, Maruyama K, Akiyama Y, Urakami K, Kusuhara M, Mochizuki T, Yamaguchi K
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 641-641
- DOI
  10.1038/s41598-017-00219-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430150, KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-15K06893
[Journal Article] Immune response-associated gene profiling in Japanese melanoma patients using multi-omics analysis2017
- Author(s)
  Akiyama Yasuto、Kiyohara Yoshio、Yoshikawa Shusuke、Otsuka Masaki、Kondou Ryota、Nonomura Chizu、Miyata Haruo、Iizuka Akira、Ashizawa Tadashi、Ohshima Keiichi、Urakami Kenichi、Nagashima Takeshi、Kusuhara Masatoshi、Sugino Takashi、Yamaguchi Ken
- Journal Title
  
  Oncology Reports
  
  Volume: 39 Pages: 1125-1131
- DOI
  10.3892/or.2017.6173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08727, KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-18K07315
[Journal Article] Comprehensive analysis of gene mutation and expression profiles in neuroendocrine carcinomas of the stomach 2017
- Author(s)
 Makuuchi R, Terashima M, Kusuhara M, Nakajima T, Serizawa M, Hatakeyama K, Ohshima K, Urakami K, Yamaguchi K.
- Journal Title
 
 Biomed. Res.
 
 Volume: 38 Issue: 1 Pages: 19-27
- DOI
 10.2220/biomedres.38.19
- NAID
 130005242938
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-16K19960, KAKENHI-PROJECT-15K06893
[Journal Article] Comprehensive characterization of genes associated with the TP53 signal transduction pathway in various tumors.2017
- Author(s)
  Ohnami S, Ohshima K, Nagashima T, Urakami K, Shimoda Y, Saito J, Naruoka A, Hatakeyama K, Mochizuki T, Serizawa M, Ohnami S, Kusuhara M, Yamaguchi K
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: March Issue: 1-2 Pages: 1-11
- DOI
  10.1007/s11010-017-2977-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430150, KAKENHI-PROJECT-15K06893
[Journal Article] Next generation sequencing approach for detecting 491 fusion genes from human cancer 2016
- Author(s)
 1.Urakami K, Shimoda Y, Ohshima K, Nagashima T, Serizawa M, Tanabe T, Saito J, Usui T, Watanabe Y, Naruoka A, Ohnami S, Ohnami S, Mochizuki T, Kusuhara M, Yamaguchi K.
- Journal Title
 
 Biomed. Res.
 
 Volume: 37 Issue: 1 Pages: 51-62
- DOI
 10.2220/biomedres.37.51
- NAID
 130005128377
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-26430150, KAKENHI-PROJECT-15K06893
[Journal Article] ProGRP is a possible tumor marker for patients with Ewing sarcoma.2015
- Author(s)
  2.Yamaguchi K, Katagiri H, Takahashi M, Ishida Y, Ono A, Takahashi T, Ohshima K, Mochizuki T, Urakami K, Muramatsu K, Kameya T, Ito I, Nakajima T.
- Journal Title
  
  Biomedical Research
  
  Volume: 36 Issue: 4 Pages: 273-277
- DOI
  10.2220/biomedres.36.273
- NAID
  130005094139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430150
[Journal Article] Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma cells.2014
- Author(s)
  Wakabayashi-Nakao K, Hatakeyama K, Ohshima K, Ken Yamaguchi K, Mochizuki T.
- Journal Title
  
  Biomed Research
  
  Volume: 35 Pages: 237-242
- NAID
  130004678579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430150
[Journal Article] Implementation of individualized medicine for cancer patients by multiomics-based analyses—the Project HOPE— 2014
- Author(s)
 Yamaguchi K, Urakami K, Ohshima K, Mochizuki T, Akiyama Y, Uesaka K, Nakajima T, Takahashi M, Tamai S, Kusuhara M.
- Journal Title
 
 Biomed. Res.
 
 Volume: 35 Issue: 6 Pages: 407-412
- DOI
 10.2220/biomedres.35.407
- NAID
 130004903868
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-26430150
[Journal Article] Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells.2014
- Author(s)
  Ohshima K, Kanto K, Hatakeyama K, Ide T, Wakabayashi-Nakao K, Watanabe Y, Sakura N, Terashima M, Yamaguchi K, Mochizuki T.
- Journal Title
  
  Proteomics
  
  Volume: 14 Issue: 20 Pages: 2297-2306
- DOI
  10.1002/pmic.201300477
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430150, KAKENHI-PROJECT-26830100
[Journal Article] Placenta-specific novel splice variants of Rho GDP dissociation inhibitor β are highly expressed in cancerous cells.2013
- Author(s)
  Hatakeyama K, Fukuda Y, Ohshima K, Terashima M, Yamaguchi K, MochizukiT
- Journal Title
  
  BMC Res Notes
  
  Volume: 5 Issue: 1 Pages: 666-666
- DOI
  10.1186/1756-0500-5-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591472, KAKENHI-PROJECT-23590703, KAKENHI-PROJECT-23701092
[Journal Article] Novel protein isoforms of carcinoembryonic antigen are secreted from pancreatic, gastric and colorectal cancer cells2013
- Author(s)
  Hatakeyama K, Wakabayashi-Nakao K, Ohshima K, Sakura N, Yamaguchi K, Mochizuki T
- Journal Title
  
  BMC Res. Notes
  
  Volume: 6 Issue: 1 Pages: 381-381
- DOI
  10.1186/1756-0500-6-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590703, KAKENHI-PROJECT-23701092, KAKENHI-PROJECT-24701014
[Journal Article] Structure-function relationship of the nuclear localization signal sequence of parathyroid hormone-related protein2012
- Author(s)
  Ohshima K, Takeda S, Hirose M, Akiyama Y, Iguchi K, Hoshino M, Yamaguchi K,Mochizuki T
- Journal Title
  
  Biomed. Res.
  
  Volume: 33 Issue: 3 Pages: 191-199
- DOI
  10.2220/biomedres.33.191
- NAID
  130004470821
- ISSN
  0388-6107, 1880-313X
- Language
  English
- Data Source
  KAKENHI-PROJECT-23590703
[Journal Article] Structure-function relationship of the nuclear localization signal sequence of parathyroid hormone-related protein2012
- Author(s)
  Ohshima K
- Journal Title
  
  Biomedical Research
  
  Volume: 33 Pages: 191-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590703
[Journal Article] Identification of a novel protein isoform derived from cancer-related splicing variants using combined analysis of transcriptome and proteome.2011
- Author(s)
  Hatakeyama K, Ohshima K, Fukuda Y, Ogura S, Terashima M, Yamaguchi K, Mochizuki T
- Journal Title
  
  Proteomic
  
  Volume: 11 Issue: 11 Pages: 2275-2282
- DOI
  10.1002/pmic.201100016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591472, KAKENHI-PROJECT-23701092
[Presentation] 超低腫瘍変異負荷を伴う膵癌の特性評価2023
- Author(s)
  今村泰輔、蘆田良、大島啓一、上坂克彦、杉浦禎一、大木克久、山田美保子、大塚新平、長嶋剛、山口建
- Organizer
  第123 回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08700
[Presentation] 日本人癌ゲノムデータベースにおける膵癌切除例のマルチオミックス解析2022
- Author(s)
  今村泰輔、蘆田良、大島啓一、上坂克彦、杉浦禎一、岡村行泰、大木克久、山田美保子、大塚新平、長嶋剛史、山口建
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08811
[Presentation] 十二指腸がん再発におけるDNAメチル化異常による遺伝子発現の変化2022
- Author(s)
  大島啓一、岡村行泰、今村泰輔、畠山慶一、大浪澄子、鎌田福美、長嶋剛史、浦上研一、杉野隆、秋山靖人、山口建
- Organizer
  第81回日本癌学会
- Data Source
  KAKENHI-PROJECT-21K08811
[Presentation] 肝細胞癌における一つの癌遺伝子に蓄積する複数の変異の展望と臨床的意義2021
- Author(s)
  今村泰輔，岡村行泰，杉浦禎一，蘆田良，大木克久，大塚新平，大島啓一，上坂克彦
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08811
[Presentation] Analysis of somatic and germline mutations of MEN1 in 5,063 cancer patients.2020
- Author(s)
  Akane Naruoka, Sumiko Ohnami, Takeshi Nagashima, Keiichi Ohshima, Masakuni Serizawa, Keiichi Hatakeyama, Shumpei Ohnami, Yasue Horiuchi, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi
- Organizer
  The 79th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-18K07343
[Presentation] 遺伝子変異総量は非置換型肺腺癌における独立した予後規定因子である2019
- Author(s)
  井坂光宏、芹澤昌邦、長嶋剛史、児嶋秀晃、今野隼人、水野鉄也、小野哲、大島啓一、秋山靖人、浦上研一、遠藤正浩、杉野隆、山口　建、高橋利明、大出泰久
- Organizer
  第78回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07792
[Presentation] オシメルチニブ耐性非小細胞肺癌細胞において活性の変化を示す代謝経路の同定2019
- Author(s)
  梅原里奈、宮脇英里子、釼持広知、大島啓一、浦上研一、解良恭一, 高橋利明、山口建、芹澤昌邦
- Organizer
  第78回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07792
[Presentation] 主要8がん種における日本人と白人のがんゲノム比較解析2019
- Author(s)
  芹澤昌邦、長嶋剛史、川端孝典、盛啓太、釼持広知、杉野隆、丸山宏二、大島啓一、浦上研一、秋山靖人、山口建
- Organizer
  第78回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07792
[Presentation] 日本人における胃癌の分子生物学的特徴2019
- Author(s)
  藤谷啓一, 芹澤昌邦, 大島啓一, 長嶋剛史, 浦上研一, 秋山靖人, 山口建, 寺島雅典
- Organizer
  第30回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] 全エキソン解析および全遺伝子発現解析の統合による胃腺癌の分子生物学的分類の検討2018
- Author(s)
  藤谷啓一, 芹澤昌邦, 楠原正俊, 浦研一, 大島啓一, 長嶋剛史, 幕内梨恵, 谷澤豊, 坂東悦郎, 川村泰一, 山口建, 寺島雅典
- Organizer
  第29回日本消化器癌発生学会
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] Potential drug-targetable driver oncogenes resulting from amplification and overexpression in 4,000 solid tumors2018
- Author(s)
  Keiichi Ohshima, Takeshi Nagashima, Keiichi Hatakeyama, Sumiko Ohnami, Shumpei Ohnami, Yuji Shimoda, Tomoe Tanabe, Masakuni Serizawa, Yasuto Akiyama, Kenichi Urakami, Masatoshi Kusuhara, Tohru Mochizuki, Ken Yamaguchi
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07343
[Presentation] 胃GISTの遺伝情報に基づいた新規バイオマーカーの探索2018
- Author(s)
  藤谷啓一, 楠原正俊, 大島啓一, 幕内梨恵, 入野誠之, 谷澤豊, 坂東悦郎, 川村泰一, 寺島雅典, 山口建
- Organizer
  第73回　日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] Whole exome sequencing and gene expression profiling of neuroendocrine carcinoma in the stomach.2016
- Author(s)
  Rie Makuuchi, Masanori Terashima, Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Keiichi Hatakeyama, Masatoshi Kusuhara, Ken Yamaguchi, Keiichi Oshima, Kennichi Urakami, Makoto Hikage
- Organizer
  2016 Gastrointestinal Cancers Symposium
- Place of Presentation
  San Francisco
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462042
[Presentation] Gene expression profiling of Japanese gastric cancer patinets using Asian Cancer Research Group classification.2016
- Author(s)
  Masanori Terashima, Rie Makuuchi, Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Makoto Hikage, Keiichi Hatakeyama, Keiichi Oshima, Shunpei Ohnami, Kennichi Urakami, Masatoshi Kusuhara, Ken Yamaguchi
- Organizer
  2016 Gastrointestinal Cancers Symposium
- Place of Presentation
  San Francisco
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462042
[Presentation] Genetic analysis of gastric cancer with distinctive family history2016
- Author(s)
  M. Terashima, K. Hatakeyama, M. Kusuhara, R. Makuuchi, M. Tokunaga, Y. Tanizawa, E. Bando, T. Kawamura, M. Hikage, S. Kaji, K. Ohshima, S. Ohnami, K. Urakami, K. Yamaguchi
- Organizer
  European Society for Medical Oncology 2016
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2016-10-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] New approach to gastric cancer classification based on TP53 mutation2016
- Author(s)
  R. Makuuchi, K. Hatakeyama, M. Terashima, M. Kusuhara, M. Tokunaga, Y. Tanizawa, E. Bando, T. Kawamura, M. Hikage, S. Kaji, K. Ohshima, S. Ohnami, K. Urakami, K. Yamaguchi
- Organizer
  European Society for Medical Oncology 2016
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2016-10-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] Cancer driver pathways in 2,000 tumors -integrated analysis of whole exome sequencing and gene expression profiling-2016
- Author(s)
  大島啓一、長嶋剛史、畠山慶一、大浪澄子、大浪俊平、下田勇治、田邉智絵、芹澤昌邦、秋山靖人、浦上研一、楠原正俊、望月徹、山口建
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26430150
[Presentation] TP53遺伝子変異を加味した新しい胃癌分類の試み2016
- Author(s)
  幕内梨恵、畠山慶一、徳永正則、谷澤豊、坂東悦郎、川村泰一、絹笠祐介、杉浦禎一、上坂克彦、大島啓一、浦上研一、楠原正俊、山口建、寺島正典
- Organizer
  第54回日本癌治療学会
- Place of Presentation
  横浜市
- Year and Date
  2016-10-20
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] 分子プロファイルに基づく胃癌の分類2015
- Author(s)
  幕内梨恵、寺島雅典、本田晋策、高木航、辰林太一、日景允、徳永正則、谷澤豊、坂東悦郎、川村泰一、畠山慶一、大島啓一、浦上研一、楠原正敏、山口建
- Organizer
  第53回日本癌治療学会
- Place of Presentation
  京都
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25462042
[Presentation] Gene expression profiling: a single institution study of 1,000 cancer patients2015
- Author(s)
  大島啓一、長嶋剛史、畠山慶一、下田勇治、田邉智絵、大浪澄子、大浪俊平、芹澤昌邦、浦上研一、秋山靖人、楠原正俊、望月徹、山口建
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430150
[Presentation] Survivin expression in circulating tumor cells of patients with gastric cancer2014
- Author(s)
  Terashima M, Hatakeyama K, Yamakawa Y, Sugisawa N, Miki Y, Makuuchi R, Goto H, Tokunaga M, Tanizawa Y, Bando E, Kawamura T, Oshima K, Mochizuki T
- Organizer
  Gastrointestinal Cancer Symposium 2014
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-25462042
[Presentation] Identification of novel protein isoforms in secretome using combined analysis of microarray and mass spectrometry2013
- Author(s)
  Hatakeyama K, Ohshima K, Wakabayashi-Nakao K, Tanizawa Y, Terashima M, Yamaguchi K, Mochizuki T
- Organizer
  第75会日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25462042
[Presentation] 膵がん細胞エクソソームに含まれるEps8タンパク質2013
- Author(s)
  大島啓一
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23590703
[Presentation] 癌細胞から放出されるエクソソーム中のプロテオーム解析2012
- Author(s)
  大島啓一
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-23590703
[Presentation] 胃癌細胞株が放出するエクソソーム中のプロテオーム解析2011
- Author(s)
  大島啓一
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23590703
[Presentation] プロジェクトHOPE（マルチオーミクス解析を用いたがん患者評価）-全遺伝子発現解析-
- Author(s)
  大島啓一、畠山慶一、中尾香菜子、長嶋剛史、下田勇治、田邉智絵、大浪澄子、大浪俊平、浦上研一、秋山靖人、楠原正俊、望月徹、山口建
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26430150
[Presentation] 胃癌細胞株が放出するエクソソーム中のプロテオーム解析
- Author(s)
  大島啓一、畠山慶一、中尾香菜子、寺島雅典、山口建、望月徹
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23590703

1. TERASHIMA Masanori (40197794)

# of Collaborated Projects: 6 results

# of Collaborated Products: 18 results
2. MOCHIZUKI Tohru (00117780)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. Kusuhara Masatoshi (40169991)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. KAWAMURA Taiichi (20283145)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OKAMURA Yukiyasu (10704489)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
6. 上坂克彦 (20283434)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
7. HATAKEYAMA Keiichi (20564157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. ENDO Yoshio (30211783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. BANDO Etsuro (70399591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ITO HIROAKI (70443447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Serizawa Masakuni (00569915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. 亀谷徹 (50101035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 近藤晴彦 (60399590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 山本信之 (60298966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 後藤満一 (50162160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 木暮道彦 (90264548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 星野豊 (30295414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 大須賀文彦 (80404870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 樫村省吾 (80398346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 米村豊 (20167042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 石川吉伸 (00305004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 釼持広知 (50602637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
23. 盛啓太 (50727534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. 杉野隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohshima Keiichi 大島 啓一

OSHIMA Keiichi 大島 啓一

大島 敬一 オオシマ ケイイチ

OHSHIMA Keiichi 大島 啓一

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空間解析を用いたGISTの発生・進展に関わる分子機構の解明Principal Investigator

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Pan-cancer multi-omics analysis toward identification of novel diagnostic and therapeutic target molecules in neuroendocrine tumorsPrincipal Investigator

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Molecular profiling of proprotein convertases toward identification of secreted pro-hormone precursor proteins as novel tumor markersPrincipal Investigator

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Exosomal microRNAs as diagnostic biomarkers in metastatic gastric cancerPrincipal Investigator

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イレッサ高感受性肺腫瘍細胞におけるEGFR遺伝子不安定性の探究Principal Investigator

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[Journal Article] Characterization of pancreatic cancer with ultra-low tumor mutational burden2023

Author(s)

Journal Title

Ohshima Keiichi 大島啓一

OSHIMA Keiichi 大島啓一

大島敬一オオシマケイイチ

OHSHIMA Keiichi 大島啓一