Tachibana Ken 立花研

… Alternative Names

立花研タチバナケン

TACHIBANA Ken 立花研

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Researcher Number	10400540
Other IDs
External Links
Affiliation (Current)	2025: 山陽小野田市立山口東京理科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 山陽小野田市立山口東京理科大学, 薬学部, 准教授 2019 – 2023: 山陽小野田市立山口東京理科大学, 薬学部, 准教授 2014 – 2017: 日本薬科大学, 薬学部, 講師 2014: 日本薬科大学, 薬学科, 講師 2013: 東京理科大学, 総合研究機構, 助教 … More 2010 – 2012: 東京理科大学, 薬学部, 助教 2011: 山形大学, 医学部, 助教 2011: 東京理科大学, 薬学部・薬学科, 助教 2007 – 2008: Yamagata University, Dept. Molecular Cancer Science, Assistant Professor 2006: 山形大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / Risk sciences of radiation/Chemicals / Risk sciences of radiation and chemicals / Pathological medical chemistry Except Principal Investigator Cerebral neurosurgery / Environmental pharmacy / Basic Section 63030:Chemical substance influence on environment-related / Experimental pathology
Keywords	Principal Investigator トキシコロジー / 神経幹細胞 / ナノ粒子 / 慢性炎症 / マイクロRNA / エピジェネティクス / 環境 / DNAメチル化 / 胎児期曝露 / 衛生 … More / 貪食細胞 / エクソソーム / 衛生化学 / ディーゼル排ガス / programmed cell death / non-apoptotic / Ras … More Except Principal Investigator programmed cell death / energy metabolism / mitochondria / Warburg effect / グリオーマ / 脳神経系 / 酸化チタン / ナノ粒子 / glycolysis / 内分泌かく乱 / 植物 / 環境中医薬品類(PPCPs) / 植物成長影響 / 植物ホルモン様作用 / 植物ホルモン / 環境中医薬品類（PPCPｓ） / JNK / Ras / 銀ナノ粒子 / 生殖系 / 次世代 / 雄性生殖系 / 二酸化チタン / カーボンブラック / 発達毒性 / 妊娠期曝露 / mTOR / PI3K / 造腫瘍能 / 悪性脳腫瘍 / 治療耐性 / 幹細胞 / 脳腫瘍学 / マイクロアレイ / ディーゼル排ガス微粒子 / 脳発達障害 / ドーパミン / モノアミン代謝 / 酸化亜鉛 / データマイニング / 発達障害 / 網羅的遺伝子発現解析 / 胎仔期曝露 / 環境衛生学 / 酸素呼吸 / がん Less

Neural stem cell dysfunction and abnormal expression of microRNA which caused by nanoparticle exposure-induced chronic inflammationPrincipal Investigator
- Principal Investigator
  
  立花研
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Tokyo University of Science, Yamaguchi
Study of the effects of PPCPs on plant growth and construction of screening system for endrine disruptors of plant
- Principal Investigator
  
  杉原数美
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Hiroshima International University
Neural stem cell dysfunction caused by abnormal expression of exosome-derived microRNA which induced by nanoparticle exposurePrincipal Investigator
- Principal Investigator
  
  立花研
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Tokyo University of Science, Yamaguchi
DNA methylation abnormality of neural stem cell and brain dysfunction caused by chronic inflammation which induced by nanoparticle exposurePrincipal Investigator
- Principal Investigator
  
  Tachibana Ken
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Tokyo University of Science, Yamaguchi
Prenatal exposure to nanoparticle disrupt the expression level of microRNA and the function of neural stem cell in the brain of mouse offspringPrincipal Investigator
- Principal Investigator
  
  Tachibana Ken
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Nihon Pharmaceutical University
The mechanism underlying the developmental toxicity of nanoparticle on the central nervous system and reproductive system of offspring
- Principal Investigator
  
  TAKEDA KEN
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tokyo University of Science
Prenatal diesel exhaust exposure disrupt the DNA methylation profile and the function of neural stem cells in the brain of mousePrincipal Investigator
- Principal Investigator
  
  TACHIBANA Ken
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nihon Pharmaceutical University
  Tokyo University of Science
Analysis of genome-wide DNA methylation profiles of the brain in mice exposed to diesel exhaust during fetal period.Principal Investigator
- Principal Investigator
  
  TACHIBANA Ken
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tokyo University of Science
Effects of nanomaterial exposure on cranial nerve system of offspring
- Principal Investigator
  
  TAKEDA Ken
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tokyo University of Science
Overcoming therapy resistance of glioma via elucidation of the mechanisms underlying glioma stem cell maintenance
- Principal Investigator
  
  KITANAKA Chifumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Yamagata University
がん細胞に特有なエネルギー代謝に着眼した難治がん治療抵抗性の病態解明と治療応用
- Principal Investigator
  
  KITANAKA Chifumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Yamagata University
Ras依存的non-apoptoticプログラム細胞死の制御に関わる分子機構Principal Investigator
- Principal Investigator
  
  立花研
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Yamagata University
Identification of novel genes that determine cell's sensitivity to anticancer treatments/cell death in malignant tumors of neuronal origin
- Principal Investigator
  
  KITANAKA Chifumi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Yamagata University

[Book] DNA methylation: Patterns, Functions and Roles in Disease2016
- Author(s)
  Ken Tachibana and Ken Takeda
- Total Pages
  21
- Publisher
  Nova Science Publishers
- Data Source
  KAKENHI-PROJECT-15K00558
[Book] DNA Methylation: Patterns, Functions and Roles in Disease2016
- Author(s)
  Tachibana K., Takeda K.
- Total Pages
  213
- Publisher
  Nova Science Publishiers, Inc.
- Data Source
  KAKENHI-PROJECT-15K00558
[Book] 科学フォーラム30 (6)号2013
- Author(s)
  立花　研
- Total Pages
  4
- Publisher
  東京理科大学
- Data Source
  KAKENHI-PROJECT-24510085
[Book] スタンダード薬学シリーズ5　健康と環境（第2版）2012
- Author(s)
  武田健、立花研
- Total Pages
  6
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-24510085
[Journal Article] ナノ粒子曝露によるDNAメチル化異常と脳機能障害2024
- Author(s)
  立花研
- Journal Title
  
  アグリバイオ
  
  Volume: 8 Pages: 99-103
- Data Source
  KAKENHI-PROJECT-22K12391
[Journal Article] ナノ粒子曝露によるDNAメチル化異常と脳機能障害2023
- Author(s)
  立花研
- Journal Title
  
  月刊細胞
  
  Volume: 55 Pages: 100-103
- Data Source
  KAKENHI-PROJECT-22K12391
[Journal Article] The long-term effects of exposure to nanoparticles2022
- Author(s)
  Ken Tachibana
- Journal Title
  
  Open Access Government
  
  Volume: 2022(1) Pages: 214-215
- Open Access
- Data Source
  KAKENHI-PROJECT-19K12342
[Journal Article] How do environmental factors affect foetal development?2021
- Author(s)
  Ken Tachibana
- Journal Title
  
  Open Access Government
  
  Volume: 2021(7) Pages: 244-245
- Open Access
- Data Source
  KAKENHI-PROJECT-19K12342
[Journal Article] Effects of Prenatal Exposure to Titanium Dioxide Nanoparticles on DNA Methylation and Gene Expression Profile in the Mouse Brain2021
- Author(s)
  Ken Tachibana, Shotaro Kawazoe, Atsuto Onoda, Masakazu Umezawa, Ken Takeda
- Journal Title
  
  Frontiers in Toxicology
  
  Volume: 3
- DOI
  10.3389/ftox.2021.705910
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12342, KAKENHI-PROJECT-19K17324
[Journal Article] Nanoparticles and their impact on DNA methylation -DNA Methylation Abnormality and Brain Dysfunction of Neural Stem Cells Caused by Chronic Inflammation by Nanoparticle Exposure-2020
- Author(s)
  Ken Tachibana
- Journal Title
  
  Impact
  
  Volume: 2020(7) Issue: 7 Pages: 28-30
- DOI
  10.21820/23987073.2020.7.28
- Open Access
- Data Source
  KAKENHI-PROJECT-19K12342
[Journal Article] Prenatal diesel exhaust exposure disrupts the DNA methylation profile in the brain of mouse offspring2015
- Author(s)
  Ken Tachibana., Kohei Takayanagi, Ayame Akimoto, Kouji Ueda, Yusuke Shinkai, Masakazu Umezawa, Ken Takeda
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 40 (1) Issue: 1 Pages: 1-11
- DOI
  10.2131/jts.40.1
- NAID
  130004904023
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24510085, KAKENHI-PROJECT-26560034
[Journal Article] Prenatal diesel exhaust exposure disrupts the DNA methylation profile in the brain of mouse offspring.2014
- Author(s)
  Tachibana K, Takayanagi K, Akimoto A, Ueda K, Shinkai Y, Umezawa M, Takeda K.
- Journal Title
  
  J,Toxicol,Sci.
  
  Volume: 40 Pages: 1-11
- NAID
  130004904023
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390033
[Journal Article] Effect of maternal exposure to carbon black nanoparticle during early gestation on the splenic phenotype of neonatal mouse.2014
- Author(s)
  Shimizu R, Umezawa M, Okamoto S, Onoda A, Uchiyama M, Tachibana K, Watanabe S, Ogawa S, Abe R, Takeda K.
- Journal Title
  
  J,Toxicol,Sci.
  
  Volume: 39 Pages: 571-578
- NAID
  130004904005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390033
[Journal Article] Prenatal exposure to zinc oxide particles alters monoaminergic neurotransmitter levels in the brain of mouse offspring.2013
- Author(s)
  Yuka Okada, Ken Tachibana, Shinya Yanagita, Ken Takeda
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 38 Pages: 363-370
- NAID
  10031158902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510085
[Journal Article] Prenatal exposure to zinc oxide particles alters monoaminergic neurotransmitter levels in the brain of mouse offspring.2013
- Author(s)
  Yuka Okada，Ken Tachibana，Shinya Yanagita，and Ken Takeda
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 38
- NAID
  10031158902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510085
[Journal Article] Prenatal exposure to zinc oxide particles alters monoaminergic neurotransmitter levels in the brain of mouse offspring.2013
- Author(s)
  Okada .Y, Tachibana. K, Yanagita. S, Takeda. K.
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 38 Pages: 363-370
- NAID
  10031158902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390033
[Journal Article] Cytoplasmic localization of DGKzeta exerts a protective effect against genotoxicity by regulating p53.2013
- Author(s)
  Toshiaki Tanaka, Masashi Okada, Yasukazu Hozumi, Ken Tachibana, Chifumi Kitanaka, Yoshioki Hamamoto, Alberto M Martelli, Matthew K Topham, Mitsuyoshi Iino, and Kaoru Goto
- Journal Title
  
  Journal of Cell Science
  
  Volume: 掲載号確定待ち
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510085
[Journal Article] Cytoplasmic localization of DGKζ exerts a protective effect against p53-mediated cytotoxicity.2013
- Author(s)
  Tanaka T, Okada M, Hozumi Y, Tachibana K, Kitanaka C, Hamamoto Y, Martelli AM, Topham MK, Iino M, Goto K.
- Journal Title
  
  J Cell Sci.
  
  Volume: 126(Pt 13) Pages: 2785-2797
- DOI
  10.1242/jcs.118711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590229, KAKENHI-PROJECT-24390044, KAKENHI-PROJECT-24510085
[Journal Article] MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis2011
- Author(s)
  Sato A
- Journal Title
  
  Stem Cells
  
  Volume: 29 Issue: 12 Pages: 1942-1951
- DOI
  10.1002/stem.753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390402, KAKENHI-PROJECT-22650235, KAKENHI-PROJECT-22710067, KAKENHI-PROJECT-23791585
[Journal Article] FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity2011
- Author(s)
  Sunayama J, Sato A, Matsuda KI, Tachibana K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
- Journal Title
  
  Stem Cells
  
  Volume: 29 Pages: 1327-1337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390402
[Journal Article] MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis2011
- Author(s)
  Sato A, Sunayama J, Matsuda K, Seino S, Suzuki K, Watanabe E, Tachibana K, Tomiyama A, Kayama T, Kitanaka C
- Journal Title
  
  StemCells
  
  Volume: 29 Pages: 1942-1951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390402
[Journal Article] Fox03a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity2011
- Author(s)
  Sunayama J, Sato A, Matsuda K, Tachibana K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
- Journal Title
  
  Stem Cells
  
  Volume: 29 Issue: 9 Pages: 1327-1337
- DOI
  10.1002/stem.696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710067, KAKENHI-PROJECT-23791585
[Journal Article] FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity2011
- Author(s)
  Sunayama J, Sato A, Matsuda K, Tachibana K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C.
- Journal Title
  
  Stem Cells
  
  Volume: Vol.29 Pages: 1327-1337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710067
[Journal Article] DNA配列に無関係な遺伝子発現調節2011
- Author(s)
  立花研
- Journal Title
  
  科学フォーラム
  
  Volume: 第28巻第1号 Pages: 42-46
- Data Source
  KAKENHI-PROJECT-22710067
[Journal Article] MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis2011
- Author(s)
  Sato A, Sunayama J, Matsuda K, Seino S, Suzuki K, Watanabe E, Tachibana K, Tomiyama A, Kayama T, Kitanaka C.
- Journal Title
  
  Stem Cells
  
  Volume: Vol.29 Pages: 1942-1951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710067
[Journal Article] Dual blocking of mTor and PI3K elicits a pro-differentiation effect on glioblastoma stem like-cells2010
- Author(s)
  Sunayama J, Sato A, Matsuda KI, Tachibana K, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
- Journal Title
  
  Neuro-Oncol
  
  Volume: 12 Pages: 1205-1219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390402
[Journal Article] Regulation of neural stem/progenitor cell maintenance by PI3K and mTOR2010
- Author(s)
  Sato A, Sunayama J, Matsuda KI, Tachibana K, Sakurada K, Tomiyama A, Kayama T, Kitanaka C
- Journal Title
  
  Neurosci Lett
  
  Volume: 410 Pages: 115-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390402
[Journal Article] MEK-ERK-dependent multiple caspase activation via mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma celldeath2010
- Author(s)
  Tomiyama A, Tachibana K, Suzuki K, Seino S, Sunayama J, Matsuda KI, Sato A, Matsumoto Y, Nomiya T, Nemoto K, Yamashita H, Kayama T, Ando K, Kitanaka C
- Journal Title
  
  Cell Death Dis
  
  Volume: 1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390402
[Journal Article] Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells2010
- Author(s)
  Sunayama J, Matsuda KI, Sato A, Tachibana K, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
- Journal Title
  
  StemCells
  
  Volume: 28 Pages: 1930-1939
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390402
[Journal Article] 癌細胞自殺の仕組み.2007
- Author(s)
  立花研・富山新太・北中千史
- Journal Title
  
  検査と技術 35
  
  Pages: 981-983
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390389
[Journal Article] 癌細胞自殺の仕組み2007
- Author(s)
  立花研、富山新太、北中千史
- Journal Title
  
  検査と技術 35
  
  Pages: 981-983
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659097
[Journal Article] 癌細胞自殺の仕組み2007
- Author(s)
  立花研、富山新太、北中千史
- Journal Title
  
  検査と技術 35
  
  Pages: 981-983
- Data Source
  KAKENHI-PROJECT-18390389
[Journal Article] 癌細胞自殺の仕組み2007
- Author(s)
  立花, 研・富山, 新太・北中, 千史
- Journal Title
  
  検査と医学 35
  
  Pages: 981-983
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790216
[Journal Article] オートファジーとautophagic cell death2006
- Author(s)
  立花研, 北中千史
- Journal Title
  
  蛋白質核酸酵素 51
  
  Pages: 1519-1524
- Data Source
  KAKENHI-PROJECT-18790216
[Journal Article] Critical role for mitochondrial oxidative phosphorylation in the activation of tumor suppressor proteins Bax and Bak2006
- Author(s)
  Tomiyama A, Serizawa S, Tachibana K, Sakurada K, Samejima H, Kuchino Y, Kitanaka C
- Journal Title
  
  J Natl Cancer Inst 98
  
  Pages: 1462-1473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390389
[Journal Article] オーファジーとautophogic cell death2006
- Author(s)
  立花研, 北中千史
- Journal Title
  
  蛋白質核酸酵素 51
  
  Pages: 1519-1524
- Data Source
  KAKENHI-PROJECT-18390389
[Presentation] 超微小粒子の胎仔期曝露が誘導する仔の脳血管周辺異常とその機序2023
- Author(s)
  小野田淳人、梅澤雅和、立花研、武田健
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-19K12342
[Presentation] フタル酸エステル類とその代謝物が核内受容体PXRおよびPPARαの転写活性に及ぼす影響2018
- Author(s)
  佐藤志穂，渡部容子、立花研、浦丸直人、小島弘幸、吉成浩一、樋口敏幸、北村繁幸
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] 埼玉県と東京都における大気中のPM2.5濃度2018
- Author(s)
  村橋毅、郭錦堂、樋口敏幸、立花研、浦丸直人、小西瑞紀、上野華子、佐々木翔子、小山彰子
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] 合成ムスク類のラットin vivoにおける肝シトクロムP450活性への影響2017
- Author(s)
  渡部容子、服部祥子、立花研、佐能正剛、太田茂、北村繁幸
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] パルマチンは単球系THP-1細胞におけるLPSによるTissue factor発現誘導を抑制する2017
- Author(s)
  広田あずさ、石山俊介、平沢百合、立花研、高野文英、樋口敏幸
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] ベンゾトリアゾール系紫外線吸収剤のPXR、CARおよびPPARα活性とシトクロムP450活性への影響2017
- Author(s)
  服部祥子、渡部容子、立花研、小島弘幸、吉成浩一、北村繁幸
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] エクソソーム内包microRNAの脳への送達2016
- Author(s)
  須山史也、立花研、小野田淳人、武田健、梅澤雅和
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] 二酸化チタンナノ粒子胎仔期曝露が脳のDNAメチル化レベル及び遺伝子発現に及ぼす影響2016
- Author(s)
  立花研、川副翔太郎、梅澤雅和、武田健
- Organizer
  フォーラム2016　衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] Disruption of Epigenetic Regulation and the Health Effect Caused by Prenatal Nano-sized Particle Exposure2016
- Author(s)
  Ken Tachibana, Kohei Takayanagi, Ayame Akimoto, Kouji Ueda, Shotaro Kawazoe, Yusuke Shinkai, Masakazu Umezawa and Ken Takeda
- Organizer
  4th International Postgraduate Conference on Pharmaceutical Sciences 2016
- Place of Presentation
  千葉
- Year and Date
  2016-02-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] 二酸化チタンナノ粒子妊娠期曝露により胎仔に生じるマイクロRNA発現変動の解析2016
- Author(s)
  立花研、黒岩法子、小島稔郁、湯浅珠恵、新海雄介、梅澤雅和、武田健
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] in vivoにおけるラット肝シトクロムP450活性に対するリン系難燃剤の影響2016
- Author(s)
  渡部容子、杉原数美、立花研、佐能正剛、太田茂、北村繁幸
- Organizer
  フォーラム2016　衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] Detection of inorganic nanoparticles and their potential targets in the brain of mice2015
- Author(s)
  Masakazu Umezawa, Fumiya Suyama, Ken Tachibana, Atsuto Onoda, Natsuko Kubota, Shinya Yanagita and Ken Takeda
- Organizer
  9th IBRO World Congress of Neuroscience (IRBO)
- Place of Presentation
  リオデジャネイロ
- Year and Date
  2015-07-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] ナノ粒子曝露が脳の発達に及ぼす影響－鋭敏なマーカーと毒性学的意義2015
- Author(s)
  梅澤雅和、小野田淳人、川副翔太郎、立花研、武田健
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] 二酸化チタンナノ粒子の胎仔期曝露により神経幹細胞に生じる遺伝子発現変動2015
- Author(s)
  立花研、小番美鈴、川副翔太郎、上田剛司、新海雄介、梅澤雅和、武田健
- Organizer
  フォーラム2015衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] RT-PCR analysis of the distribution of exosomes with exogenous miRNA to the brain2015
- Author(s)
  Fumiya Suyama, Ken Tachibana, Atsuto Onoda, Ken Takeda, Masakazu Umezawa
- Organizer
  12th European Nutrition Conference (FENS)
- Place of Presentation
  ベルリン
- Year and Date
  2015-10-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00558
[Presentation] ディーゼル排ガス胎仔期曝露により脳に生じるDNAメチル化異常の解析2014
- Author(s)
  立花研、高柳皓平、秋本純芽、上田剛司、新海雄介、梅澤雅和、武田健
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] ディーゼル排ガス胎仔期曝露により脳に生じるDNAメチル化異常の解析2014
- Author(s)
  立花研、高柳皓平、秋本純芽、上田剛司、新海雄介、梅澤雅和、武田健
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390033
[Presentation] Effect of prenatal exposure to titanium dioxide nanoparticle on the gene expression in the brain of mouse offspring.2013
- Author(s)
  Tachibana K, Kawazoe S, Umezawa M, Takeda K.
- Organizer
  10th International Particle Toxicology Conference
- Place of Presentation
  Germany
- Data Source
  KAKENHI-PROJECT-24390033
[Presentation] 妊娠期の酸化チタンナノ粒子曝露による羊水中マイクロ RNA 発現変動の解析2013
- Author(s)
  湯浅珠恵、立花研、小島稔郁、武田健
- Organizer
  第5回日本RNAi研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24390033
[Presentation] Effect of Prenatal Exposure to Titanium Dioxide Nanoparticle on microRNA Expression in Mouse Embryo.2013
- Author(s)
  Tachibana K, Kojima T, Kuroiwa N, Yuasa T, Umezawa M, Takeda K.
- Organizer
  6th International Symposium on Nanotechnology, Occupational and Environmental Health (NanOEH6).
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-24390033
[Presentation] ディーゼル排ガス胎仔期曝露によるDNAメチル化状態の網羅的解析2013
- Author(s)
  上田剛司、立花研、高柳皓平、秋本純芽、新海雄介、武田健
- Organizer
  フォーラム2013衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] 妊娠期の酸化チタンナノ粒子曝露による羊水中マイクロ RNA 発現変動の解析2013
- Author(s)
  湯浅珠恵、立花研、小島稔郁、武田健
- Organizer
  第5回日本RNAi研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] 妊娠期の酸化チタンナノ粒子曝露による胎盤のマイクロ RNA 発現量の変動の解析2013
- Author(s)
  小島稔郁、立花研、黒岩法子、新海雄介、武田健
- Organizer
  第5回日本RNAi研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24390033
[Presentation] ディーゼル排ガス胎仔期曝露によるDNAメチル化状態の網羅的解析2013
- Author(s)
  上田剛司、立花　研、高柳皓平、秋本純芽、新海雄介、武田　健
- Organizer
  フォーラム2013衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24390033
[Presentation] Effect of prenatal exposure to titanium dioxide nanoparticle on the gene expression in the brain of mouse offspring.2013
- Author(s)
  Ken Tachibana, Shotaro Kawazoe, Masakazu Umezawa, Ken Takeda
- Organizer
  10th International Particle Toxicology Conference
- Place of Presentation
  ドイツ
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] Effect of Prenatal Exposure to Titanium Dioxide Nanoparticle on microRNA Expression in Mouse Embryo.2013
- Author(s)
  Ken Tachibana, Toshifumi Kojima, Noriko Kuroiwa, Tamae Yuasa, Masakazu Umezawa, Ken Takeda.
- Organizer
  6th International Symposium on Nanotechnology, Occupational and Environmental Health
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] 妊娠期の酸化チタンナノ粒子曝露による胎盤のマイクロ RNA 発現量の変動の解析2013
- Author(s)
  小島稔郁、立花研、黒岩法子、新海雄介、武田健
- Organizer
  第5回日本RNAi研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] マイクロアレイと遺伝子アノテーションを用いたレチノールおよびサリドマイドの発生毒性評価2012
- Author(s)
  梅澤雅和、末成由美、柳田信也、立花研、武田健
- Organizer
  フォーラム2012 衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation]2012
- Author(s)
  立花研, 高柳皓平, 秋本純芽, 新海雄介, 武田健
- Organizer
  日本薬学会第132年会
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21390037
[Presentation] ディーゼル排ガス胎仔期曝露が DNA メチル化に与える影響の網羅的解析2012
- Author(s)
  秋本純芽、立花研、高柳浩平、上田剛司、新海雄介、武田健
- Organizer
  フォーラム2012 衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] ディーゼル排ガス胎仔期曝露によるDNAメチル化異常の網羅的解析2012
- Author(s)
  立花研, 高柳皓平, 秋本純芽, 新海雄介, 武田健
- Organizer
  日本薬学会第132年会
- Place of Presentation
  高等教育推進機構他(札幌)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21390037
[Presentation] Effects of prenatal exposure to titanium dioxide nanoparticles on dopaminergic systems in mice.2012
- Author(s)
  Tachibana, K. Takahashi, Y. Kuroiwa, N. Oba, T. Umezawa, M. Takeda K.
- Organizer
  The 6th International Conference on Nanotoxicology
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PROJECT-24390033
[Presentation] Prenatal exposure to diesel exhaust affects central nervous system of offspring in mice.2012
- Author(s)
  Ken Tachibana, Kohei Takayanagi, Ayame Akimoto, Koji Ueda, Yusuke Shinkai, Ken Takeda
- Organizer
  1st International Postgraduate Conference on Pharmaceutical Sciences 2012
- Place of Presentation
  マレーシア
- Invited
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] Prenatal exposure to diesel exhaust affects central nervous system of offspring in mice.2012
- Author(s)
  Tachibana, K. Takayanagi, K. Akimoto, A. Ueda, K. Shinkai. Y. Takeda. K.
- Organizer
  1st International Postgraduate Conference 2012
- Place of Presentation
  Malaysia(招待講演)
- Data Source
  KAKENHI-PROJECT-24390033
[Presentation] 血中マイクロRNAをバイオマーカーとする粒子状物質の新規安全性評価手法開発の試み2012
- Author(s)
  小平伊織、立花研、夘月諒、黒岩法子、新海雄介、武田健
- Organizer
  第４回日本RNAi研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] 環境化学物質により次世代に生じる健康影響2012
- Author(s)
  立花研
- Organizer
  日本幼少児健康教育学会第30回記念大会
- Place of Presentation
  野田(千葉)
- Year and Date
  2012-02-19
- Data Source
  KAKENHI-PROJECT-22710067
[Presentation] ディーゼル排ガス胎仔期曝露によるDNAメチル化異常の網羅的解析2012
- Author(s)
  立花研、高柳皓平、秋本純芽、新海雄介、武田健
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌(北海道)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22710067
[Presentation] 妊娠期の酸化チタンナノ粒子曝露による胎仔、胎盤のマイクロRNA発現量の変動の解析2012
- Author(s)
  小島稔郁、立花研、黒岩法子、新海雄介、武田健
- Organizer
  第４回日本RNAi研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] ディーゼル排ガス成獣期曝露による肺、心臓、肝臓のマイクロRNA発現変動解析2012
- Author(s)
  夘月諒、立花研、小平伊織、黒岩法子、新海雄介、武田健
- Organizer
  第４回日本RNAi研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] ディーゼル排ガス胎仔期曝露がDNAメチル化に与える影響の網羅的解析2012
- Author(s)
  秋本純芽、立花研、高柳浩平、上田剛司、新海雄介、武田健
- Organizer
  フォーラム2012衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24390033
[Presentation] Effects of prenatal exposure to titanium dioxide nanoparticles on dopaminergic systems in mice.2012
- Author(s)
  Ken Tachibana，Yuta Takahashi，Noriko Kuroiwa，Taro Oba，Masakazu Umezawa，Ken Takeda
- Organizer
  Nanotoxicology 2012
- Place of Presentation
  中国
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] MEK inhibition enhances temozolomide sensitivity of glioma stem-like cells via MGMTdown-regulation2011
- Author(s)
  Sato A, Matsuda KI, Sunayama J, Sakurada K, Tachibana K, Tomiyama A, Kitanaka C, Kayama T
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋(名古屋国際会議場)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21390402
[Presentation] 胎仔期にディーゼル排ガスに曝露されたマウスにおけるDNAメチル化状態の網羅的解析2011
- Author(s)
  高柳皓平、立花研、秋本純芽、新海雄介、武田健
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡(静岡)
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22710067
[Presentation] 胎仔期にディーゼル排ガスに曝露されたマウスにおけるDNAメチル化状態の網羅的解析2011
- Author(s)
  高柳皓平、立花研、秋本純芽、新海雄介、武田健
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21390037
[Presentation] 血中miRNAを利用したナノ粒子の次世代健康影響評価系の検討2011
- Author(s)
  黒岩法子、立花研、小平伊織、新海雄介、武田健
- Organizer
  第3回日本RNAi研究会
- Place of Presentation
  グランドプリンスホテル(広島)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-21390037
[Presentation] MEK経路阻害によるMGMT発現およびテモゾロミド感受性に関する検討2011
- Author(s)
  佐藤篤,松田憲一朗,砂山潤,清野静香,鈴木香,櫻田香,立花研,富山新太,北中千史,嘉山孝正
- Organizer
  第70回日本脳神経外科学会総会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2011-10-12
- Data Source
  KAKENHI-PROJECT-21390402
[Presentation] グリオーマ幹細胞における FoxO3aを介した分化と造腫瘍能の制御2011
- Author(s)
  佐藤篤,砂山潤,松田憲一朗,立花研,渡部江梨子,清野静香,鈴木香,成田善孝,渋井壮一郎,富山新太,北中千史,嘉山孝正
- Organizer
  第29回日本脳腫瘍学会学術総会
- Place of Presentation
  下呂(水明館)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-21390402
[Presentation] 血中miRNAを利用したナノ粒子の次世代健康影響評価系の検討2011
- Author(s)
  黒岩法子、立花研、小平伊織、新海雄介、武田健
- Organizer
  3回日本RNAi研究会
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-21390037
[Presentation] グリオーマ幹細胞におけるMGMT発現制御の分子機構に関する検討2011
- Author(s)
  佐藤篤,松田憲一朗,砂山潤,清野静香,鈴木香,渡部江梨子,立花研,富山新太,北中千史,嘉山孝正
- Organizer
  第12回日本分子脳神経外科学会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-21390402
[Presentation] 胎仔期にディーゼル排ガスに曝露されたマウスにおけるDNAメチル化状態の網羅的解析2011
- Author(s)
  高柳皓平、立花研、秋本純芽、新海雄介、武田健
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22710067
[Presentation] 胎仔期にディーゼル排ガスに曝露されたマウスにおけるDNAメチル化状態の網羅的解析2011
- Author(s)
  高柳皓平、立花研、秋本純芽、新海雄介、武田健
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県立大学他
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-21390037
[Presentation] Effects of prenatal exposure to zinc oxide nanoparticles on monoaminergic systems in mice.2010
- Author(s)
  Okada Y, Shinotsuka T, Tachibana K, Takeda K.
- Organizer
  Nanotoxicology 2010
- Place of Presentation
  Edinburgh, Scotland
- Year and Date
  2010-06-03
- Data Source
  KAKENHI-PROJECT-21390037
[Presentation] Regulation of neural stem/progenitor cell maintenance by PI3K and mTOR2010
- Author(s)
  Sato A, Sunayama J, Matsuda KI, Tachibana K, Sakurada K, Tomiyama A, Kayama T, Kitanaka C
- Organizer
  The 18^<th> International Conference on Brain Tumor Research and Therapy
- Place of Presentation
  Travemuende (Gran Spa Resort Arosa Travemuende)
- Year and Date
  2010-03-18
- Data Source
  KAKENHI-PROJECT-21390402
[Presentation] 酸化チタンナノ粒子胎仔期曝露がドパミン神経系に及ぼす影響2010
- Author(s)
  大庭太郎、岡田悠佳、高橋雄大、黒岩法子、水尾圭祐、立花研、武田健
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21390037
[Presentation] グリオーマ幹細胞における MGMT発現とテモゾロミド感受性に関する検討2010
- Author(s)
  佐藤篤 ,松田憲一朗 ,砂山潤 ,清野静香 ,鈴木香 ,櫻田香 ,立花研 ,富山新太 ,北中千史 ,嘉山孝正
- Organizer
  第28回日本脳腫瘍学会
- Place of Presentation
  軽井沢(軽井沢プリンスホテル)
- Year and Date
  2010-11-28
- Data Source
  KAKENHI-PROJECT-21390402
[Presentation] Effects of prenatal exposure to zinc oxide nanoparticles on monoaminergic systems in mice2010
- Author(s)
  Okada Y, Shinotsuka T, Tachibana K, Takeda K
- Organizer
  Nanotoxicology 2010
- Place of Presentation
  Edinburgh, Scotland
- Data Source
  KAKENHI-PROJECT-21390037
[Presentation] Critical role for mitochondrial oxidative phosphorylation in the activation of tumor suppressor Bax and Bak2007
- Author(s)
  Tomiyama A, Tachibana K, Kuchino Y, Kitanaka C:
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19659097
[Presentation] Analysis on the mechanism of stem cell maintenance in glioma2007
- Author(s)
  Sato A, Sunayama J, Tomiyama A, Tachibana K, Sakurada K, Kayama T, Kitanaka C
- Organizer
  The 25th Annual Meeting of the Japan Society for Neuro-Oncology
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390389
[Presentation] Critical role for mitochondrial oxidative phosphorylation in the activation of tumor suppressor Bax and Bak2007
- Author(s)
  Tomiyama, A., Tachibana, K., Kuchino, Y., Kitanaka, C.
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18790216
[Presentation] Critical role for mitochondrial oxidative phoshorylation in the activation of tumor suppressor Bax and Bak2007
- Author(s)
  Tomiyama A, Tachibana K, Kuchimo Y, Kitanaka C:
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390389
[Presentation] Critical role for mitochondrial oxidative phosphorylation in the activation of tumor suppressor proteins Bax and Bak2007
- Author(s)
  Tomiyama A, Tachibana K, Kuchino Y, Kitanaka C
- Organizer
  The 66th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390389
[Presentation] グリオーマにおける幹細胞維持機構に関する検討2007
- Author(s)
  佐藤篤・砂山潤・富山新太・立花研・櫻田香・嘉山孝正・北中千史
- Organizer
  第25回日本脳腫瘍学会
- Place of Presentation
  東京都港区
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390389
[Presentation] Role for c-Jun N-terminal kinase(JNK) in Ras-mediated non-apoptotic programmed cell death2007
- Author(s)
  Mouri W, Sato A, Tachibana K, Sakurada K, Kayama T, Kitanaka C
- Organizer
  Internatinal Symposium in Yamagata
- Place of Presentation
  Yamagata
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390389
[Presentation] Ras依存的non-apopt.ot.icプログラム細胞死におけるJNKのユニークな役割2006
- Author(s)
  毛利渉・立花研・嘉山孝正・北中千史
- Organizer
  第65回日本癌学会総会
- Place of Presentation
  横浜市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390389
[Presentation] グリオーマにおける幹細胞維持機構に関する検討2006
- Author(s)
  佐藤篤・立花研・櫻田香・嘉山孝正・北中千史
- Organizer
  第24回日本脳腫瘍学会
- Place of Presentation
  北海道・阿寒湖
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390389
[Presentation] Effects of prenatal exposure to titanium dioxide nanoparticle on DNA methylation and gene expression profile in the brain of mouse.
- Author(s)
  Kawazoe S, Tachibana K, Takeda K, Umezawa M.
- Organizer
  PPTOXIV,the 4th International Conference on Fetal Programming and Developmental Toxicity, Endocrine Society.
- Place of Presentation
  Boston Marriott Long Whart Hotel(Boston,USA)
- Year and Date
  2014-10-28 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-24390033
[Presentation] 幼児期マウスの脾臓mRNAならびにmiRNA発現プロファイルに認められる性差の機能的特徴
- Author(s)
  梅澤雅和、立花研、岡本沙紀、武田健
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] ディーゼル排ガスおよびナノ粒子曝露の生体影響におけるマイクロRNAの関与
- Author(s)
  立花研，武田健
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] 二酸化チタンナノ粒子の胎仔期曝露により神経幹細胞に生じる遺伝子発現変動
- Author(s)
  小番美鈴、立花研、川副翔太郎、上田剛司、新海雄介、梅澤雅和、武田健
- Organizer
  フォーラム2014 衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば国際会議場(茨城県)
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24390033
[Presentation] Effects of prenatal exposure to titanium dioxide nanoparticle on DNA methylation and gene expression profile in the brain of mouse.
- Author(s)
  Kawazoe S., Tachibana K., Takeda K., Umezawa M.
- Organizer
  PPTox IV Environmental Stressors in Disease and Implications for Human Health
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2014-10-26 – 2014-10-29
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] 高脂肪食を摂取したマウスの血清中ナノコロイドの解析
- Author(s)
  須山史也、谷口烈、吉川洋一郎、立花研、武田健、梅澤雅和
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] 二酸化チタンナノ粒子の胎仔期曝露により神経幹細胞に生じる遺伝子発現変動
- Author(s)
  小番美鈴、立花研、川副翔太郎、上田剛司、新海雄介、梅澤雅和、武田健
- Organizer
  フォーラム2014衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] 妊娠期に曝露したナノマテリアルによる次世代への影響
- Author(s)
  武田健、立花研、梅澤雅和
- Organizer
  フォーラム2014衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば
- Year and Date
  2014-09-19 – 2014-09-20
- Invited
- Data Source
  KAKENHI-PROJECT-24510085
[Presentation] ディーゼル排ガス曝露により肺で生じるマイクロRNA発現変動の解析
- Author(s)
  立花研、夘月諒、小平伊織、黒岩法子、新海雄介、武田健
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24510085

1. KITANAKA Chifumi (70260320)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
2. TAKEDA Ken (80054013)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
3. YANAGITA Shinya (80461755)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. UMEZAWA Masakazu (60615277)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. SUGAMATA Masao (50049863)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SHINKAI Yusuke (80459734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. SUZUKI Kenichro (30548384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NEMOTO Kenji (10208291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. SUNAYAMA Jun (80466606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
10. TOMIYAMA Arata (40385810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
11. YANAGITA Shinya (80471755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 杉原数美 (20271067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 田山剛崇 (80389121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 清水良 (00570491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 八月朔日泰和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 後藤薫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tachibana Ken 立花 研

立花 研 タチバナ ケン

TACHIBANA Ken 立花 研

Research Projects

Research Products

Co-Researchers

Neural stem cell dysfunction and abnormal expression of microRNA which caused by nanoparticle exposure-induced chronic inflammationPrincipal Investigator

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Study of the effects of PPCPs on plant growth and construction of screening system for endrine disruptors of plant

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Neural stem cell dysfunction caused by abnormal expression of exosome-derived microRNA which induced by nanoparticle exposurePrincipal Investigator

Principal Investigator

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Review Section

Research Institution

DNA methylation abnormality of neural stem cell and brain dysfunction caused by chronic inflammation which induced by nanoparticle exposurePrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Prenatal exposure to nanoparticle disrupt the expression level of microRNA and the function of neural stem cell in the brain of mouse offspringPrincipal Investigator

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The mechanism underlying the developmental toxicity of nanoparticle on the central nervous system and reproductive system of offspring

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Prenatal diesel exhaust exposure disrupt the DNA methylation profile and the function of neural stem cells in the brain of mousePrincipal Investigator

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Analysis of genome-wide DNA methylation profiles of the brain in mice exposed to diesel exhaust during fetal period.Principal Investigator

Principal Investigator

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Effects of nanomaterial exposure on cranial nerve system of offspring

Principal Investigator

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Overcoming therapy resistance of glioma via elucidation of the mechanisms underlying glioma stem cell maintenance

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がん細胞に特有なエネルギー代謝に着眼した難治がん治療抵抗性の病態解明と治療応用

Principal Investigator

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Ras依存的non-apoptoticプログラム細胞死の制御に関わる分子機構Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Identification of novel genes that determine cell's sensitivity to anticancer treatments/cell death in malignant tumors of neuronal origin

Principal Investigator

Tachibana Ken 立花研

立花研タチバナケン

TACHIBANA Ken 立花研

[Book] スタンダード薬学シリーズ5　健康と環境（第2版）2012