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KUNINAKA Shinji  國仲 慎治

ORCIDConnect your ORCID iD *help
Researcher Number 10404336
Affiliation (based on the past Project Information) *help 2012 – 2014: 慶應義塾大学, 医学部, 講師
2007 – 2010: Keio University, School of Medicine, Instructor
2006: 熊本大学, 大学院医学薬学研究部, 助手
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / General medical chemistry / Biological Sciences
Keywords
Principal Investigator
WARTS / APC/C / Cdhl / C / APC / Cdh1 / Latsl kinase / HtrA2 protease / Omi / 脾臓 … More / 胸腺 / mnd2マウス / Lats1キナーゼ / Omiプロテアーゼ / mitotic exit network / Lats1 / Mitotic exit network / CDC26 / PLK1 / MYPT1 / LATS1 / Mitotic Exit Network / TSC / TGC / 浸潤転移 / 癌 / 接着班 / stress fiber / p190 / Rho / trophoblast giant cell / gene-trap / troPhoblast giant cell / trophoblast stem cell / endoreplication / 発生・分化 Less
  • Research Projects

    (4 results)
  • Research Products

    (49 results)
  • Co-Researchers

    (4 People)
  •  Elucidation of tumor suppresive role of mammalian Mitotic Exit NetworkPrincipal Investigator

    • Principal Investigator
      KUNINAKA Shinji
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Keio University
  •  哺乳類動物におけるAPC活性化因子cdh1による多倍体化制御機構とその意義の解明Principal Investigator

    • Principal Investigator
      國仲 慎治
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Keio University
  •  The role of Anaphase-Promoting Co mplex(APC)Activator Cdh1 on cell motilityPrincipal Investigator

    • Principal Investigator
      KUNINAKA Shinji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Keio University
  •  Analysis of serine protease Omi-mediated-signaling pathway which could affect both tumorigenesis and neurodegenerative disorderPrincipal Investigator

    • Principal Investigator
      KUNINAKA Shinji
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Keio University
      Kumamoto University

All 2015 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book Other

  • [Book] 細胞周期フロンティア(佐方功幸・稲垣昌樹・岸本健雄編)2010

    • Author(s)
      國仲慎治,佐谷秀行
    • Publisher
      共立出版
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Book] 細胞周期フロンティア(佐方功幸・稲垣昌樹・岸本健雄編)2010

    • Author(s)
      國仲慎治, 佐谷秀行
    • Total Pages
      252
    • Publisher
      共立出版
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Journal Article] LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C.2015

    • Author(s)
      Masuda K, Chiyoda T, Sugiyama N, Segura-Cabrera A, Kabe Y, Ueki A, Banno K, Suematsu M, Aoki D, Ishihama Y, Saya H, Kuninaka S
    • Journal Title

      PLoS One

      Volume: 10 Issue: 2 Pages: 1-22

    • DOI

      10.1371/journal.pone.0118662

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24590360, KAKENHI-PROJECT-26830125, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-15K20161, KAKENHI-PROJECT-14J04635
  • [Journal Article] APCCDH1 targets MgcRacGAP for destruction in the late M phase.2013

    • Author(s)
      Nishimura, K
    • Journal Title

      PLOS One

      Volume: 8 Issue: 5 Pages: e63001-e63001

    • DOI

      10.1371/journal.pone.0063001

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-24590360
  • [Journal Article] Twist2 functions as a tumor suppressor in murine osteosarcoma cells.2013

    • Author(s)
      Ishikawa T, Shimizu T, Ueki A, Yamaguchi S, Onishi N, Sugihara E, Kuninaka S, Miyamoto T, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Mabuchi Y, Matsuzaki Y, Yamaguchi R, Miyano S and Saya H
    • Journal Title

      Cancer Sci

      Volume: (in press) Issue: 7 Pages: 880-888

    • DOI

      10.1111/cas.12163

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-24390359, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24590360, KAKENHI-PROJECT-24592244, KAKENHI-PROJECT-24659789, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245
  • [Journal Article] The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells.2013

    • Author(s)
      Naoe H, Chiyoda T, Ishizawa J, Masuda, K, Saya H and Kuninaka S
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 430 Issue: 2 Pages: 757-62

    • DOI

      10.1016/j.bbrc.2012.11.075

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590360
  • [Journal Article] cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.2013

    • Author(s)
      Kim M, Kim M, Lee S, Kuninaka S, Saya H, Lee H, Lee S and Lim DS.
    • Journal Title

      EMBO J

      Volume: 32 Issue: 11 Pages: 1543-55

    • DOI

      10.1038/emboj.2013.102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590360
  • [Journal Article] LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression2012

    • Author(s)
      Chiyoda, T.
    • Journal Title

      J Cell Biol

      Volume: 197 Issue: 5 Pages: 625-41

    • DOI

      10.1083/jcb.201110110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20227006, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24590360, KAKENHI-PROJECT-24659017, KAKENHI-PUBLICLY-23134507, KAKENHI-PUBLICLY-24116513
  • [Journal Article] DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells2012

    • Author(s)
      Akiko Takahashi
    • Journal Title

      Molecular Cell

      Volume: 45 Issue: 1 Pages: 123-131

    • DOI

      10.1016/j.molcel.2011.10.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J10697, KAKENHI-PLANNED-19057011, KAKENHI-PUBLICLY-22019043, KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-23112101, KAKENHI-PROJECT-23300352, KAKENHI-PROJECT-24590360, KAKENHI-PROJECT-24657155
  • [Journal Article] Fibroblast Growth Factor-2 Is an Important Factor that Maintains Cellular Immaturity and Contributes to Aggressiveness of Osteosarcoma2012

    • Author(s)
      Shimizu T., et al
    • Journal Title

      Mol Cancer Res

      Volume: 10(3) Issue: 3 Pages: 454-468

    • DOI

      10.1158/1541-7786.mcr-11-0347

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06969, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-22241052, KAKENHI-PROJECT-22700865, KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-23791293, KAKENHI-PROJECT-24590360
  • [Journal Article] Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12.2011

    • Author(s)
      Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, Onishi N, Sugihara E, Nagano O, Banno K, Kuninaka S, Aoki D, Saya H
    • Journal Title

      Am J Pathol (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress.2011

    • Author(s)
      Ishizawa J, Kuninaka S, Sugihara E, Naoe H, Kobayashi Y, Chiyoda T, Ueki A, Araki K, Yamamura KI, Matsuzaki Y, Nakajima H, Ikeda Y, Okamoto S, Saya H
    • Journal Title

      Cancer Sci. 102

      Pages: 1349-7006

    • NAID

      10029293305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.2010

    • Author(s)
      Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda Y, Suda T, Saya H
    • Journal Title

      Oncogene 29

      Pages: 5687-99

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Journal Article] The APC/C activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.2010

    • Author(s)
      Naoe, Kuninaka, S, et al.
    • Journal Title

      Mol Cell Biol

      Volume: 30 Pages: 3994-4005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.2010

    • Author(s)
      Shimizu, Kuninaka, S, et al.
    • Journal Title

      Oncogene

      Volume: 29 Pages: 5687-99

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Journal Article] The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.2010

    • Author(s)
      Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H, Kuninaka S
    • Journal Title

      Mol Cell Biol 30

      Pages: 3994-4005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Journal Article] Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation2007

    • Author(s)
      S Kuninaka, et. al.
    • Journal Title

      Oncogene 26

      Pages: 2395-2406

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Journal Article] Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation2007

    • Author(s)
      Shinji, Kuninaka, et. al.
    • Journal Title

      Oncogene 26-17

      Pages: 2395-2406

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Journal Article] WARTSキナーゼを介した器官サイズ制御と発癌抑制の接点2006

    • Author(s)
      國仲 慎治, 他
    • Journal Title

      実験医学 24・11

      Pages: 1610-1615

    • Data Source
      KAKENHI-PROJECT-18590300
  • [Journal Article] WARTSキナーゼを介した器官サイズ制御と発癌抑制の接点2006

    • Author(s)
      國仲 慎治、佐谷 秀行
    • Journal Title

      実験医学 24

      Pages: 1610-1615

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Journal Article] Organ size control mediated by WARTS kinase play a role in tumor suppression2006

    • Author(s)
      Shinji, Kuninaka, Hideyuki, Saya
    • Journal Title

      Experimental Medicine 24-11

      Pages: 1610-1615

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Journal Article] Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.

    • Author(s)
      Kuninaka, S et al.
    • Journal Title

      Oncogene (in press)

    • Data Source
      KAKENHI-PROJECT-18590300
  • [Presentation] TILLINGライブラリより樹立したneurofibromatosis 1 (nf1)変異メダカの解析2013

    • Author(s)
      國仲慎治、松崎ゆり子、亀井保博、谷口善仁、佐谷秀行
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24590360
  • [Presentation] Missense mutation of threonine 1157 at a RasGAP-related domain of Medaka nf1 affects Ras signaling pathway.2013

    • Author(s)
      Kuninaka S, Matsuzaki Y, Kami Y, Taniguchi Y, Saya H
    • Organizer
      Children’s Tumor Foundation Conference
    • Place of Presentation
      Monterey CA, USA
    • Data Source
      KAKENHI-PROJECT-24590360
  • [Presentation] APC/C活性化因子Cdh1/Fzr1のRho制御因子としての新しい役割2010

    • Author(s)
      國仲慎治, 他
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      大阪、大阪国際会議場
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Presentation] The APC/C activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.2010

    • Author(s)
      Naoe, Kuninaka S, et al.
    • Organizer
      EMBO Workshop : The Interface between the Ubiquitin Family and the DNA Damage Response
    • Place of Presentation
      Red Island, Rovinj, Croatia
    • Year and Date
      2010-09-02
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Presentation] APC/C活性化因子Cdh1/Fzr1のRho制御因子としての新しい役割2010

    • Author(s)
      國仲慎治、他
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Presentation] APC/C activator Cdh1 coordinately regulates cell cycle and differentiation in tronhoblast stem cells2009

    • Author(s)
      國仲慎治, 他
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Presentation] Anaphase promoting complex (APC) activator Cdh1 modulates RhoGTPase activity by targeting p190 RhoGAP for degradation2009

    • Author(s)
      直江秀昭、國仲慎治、他
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Presentation] APC/C activator Cdh1 coordinately regulates cell cycle and differentiation in trophoblast stem cells2009

    • Author(s)
      國仲慎治、他
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Presentation] Anaphase promoting complex (APC) activator Cdh1 modulates RhoGTPase activity by targeting p190 RhoGAP for degradation2009

    • Author(s)
      直江秀昭、國仲慎治, 他
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Data Source
      KAKENHI-PROJECT-20058033
  • [Presentation] APC/C activator Cdh1 coordinately regulates cell cycle and differentiation in trophoblast stem cells2009

    • Author(s)
      國仲慎治, 他
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Data Source
      KAKENHI-PROJECT-20058033
  • [Presentation] Anaphase promoting complex(APC)activator Cdh1 modulates RhoGTPase activity by targeting p190 RhoGAP for degradation2009

    • Author(s)
      直江秀昭, 國仲慎治, 他
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Presentation] 胎盤から見た細胞周期因子APC/cdhlの機能2008

    • Author(s)
      佐谷秀行, 國仲慎治, 他
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Presentation] Anaphase promoting complex(APC)活性化因子cdh1はRhoGTPaseの新規調節因子である2008

    • Author(s)
      直江秀昭、國仲慎治、他
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Presentation] Anaphase promoting complex(APC)活性化因子cdh1はRhoGTPaseの新規調節因子である2008

    • Author(s)
      直江秀昭、國仲慎治、他
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-20058033
  • [Presentation] 胎盤から見た細胞周期因子APC/cdh1の機能2008

    • Author(s)
      佐谷秀行、國仲慎治、他
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-20590315
  • [Presentation] 胎盤から見た細胞周期因子APC/cdhlの機能2008

    • Author(s)
      佐谷秀行、國仲慎治、他
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-20058033
  • [Presentation] 遺伝子トラップマウスを用いたAPC活性化因子cdhlの機能解析2007

    • Author(s)
      國仲 慎治, 他
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Presentation] Genetic ablation of anaphase promoting complex (APC) activator, cdh1, in mice2007

    • Author(s)
      Shinji, Kuninaka, et. al.
    • Organizer
      66th Annual meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Presentation] Functional crosstalk between WARTS/Lats 1 kinase and Omi/HtrA2 protease to regulate cell death and cell proliferation2006

    • Author(s)
      Shinji, Kuninaka
    • Organizer
      21st Century COE Colloquium : Animal models of Cancer Research
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-10-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Presentation] WARTS kinase is activated at early G1 phase and phosphorylation of its N-terminal residue is important for the activation2006

    • Author(s)
      Masanobu, Nomura, Shinji, Kuninaka, et. al.
    • Organizer
      65th Annual meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Presentation] WARTSキナーゼを介した器官サイズ制御と癌抑制機構2006

    • Author(s)
      國仲 慎治, 他
    • Organizer
      第65回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Presentation] Organ size control and tumor suppression mediated by WARTS kinase2006

    • Author(s)
      Shinji, Kuninaka, et. al.
    • Organizer
      65th Annual meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Presentation] WARTSキナーゼとOmiプロテアーゼの相互作用による細胞周期、細胞死の制御2006

    • Author(s)
      國仲 慎治
    • Organizer
      21世紀COEコロキウム:癌研究における動物モデル
    • Place of Presentation
      京都
    • Year and Date
      2006-10-07
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Presentation] がん抑制キナーゼWARTSのG1期における活性とその制御2006

    • Author(s)
      野村 眞欣、國仲 慎治, 他
    • Organizer
      第65回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590300
  • [Presentation] LATS1/MYPT1 を介した新規PLK1 活性制御機構-分裂期キナーゼの新しい機能相関-

    • Author(s)
      千代田達幸、國仲慎治、増田健太、清水孝恒、有馬好美、津田浩史、青木大輔、佐谷秀行
    • Organizer
      第71 回日本癌学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24590360
  • [Presentation] 分裂期脱出ネットワークによ るG2/M DNA 損傷チェックポイント制御

    • Author(s)
      國仲慎治、千代田達幸、杉山直幸、石濱泰、青木大輔、佐谷秀行
    • Organizer
      第71 回日本癌学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24590360
  • []

  • 1.  SAYA Hideyuki (80264282)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  ISHIHAMA YASUSHI
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  SUGIYAMA Naoyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  杉原 英志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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