KAWAMOTO Yoshiyuki 川本善之

Researcher Number	10410664
Other IDs
Affiliation (Current)	2025: 中部大学, 生命健康科学部, 准教授
Affiliation (based on the past Project Information) *help	2009 – 2024: Chubu University, 生命健康科学部, 准教授 2007 – 2008: Chubu University, 生命健康科学部, 講師
Review Section/Research Field	Principal Investigator Laboratory animal science / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Health science and related fields / Laboratory animal science Except Principal Investigator General surgery / Basic Section 38050:Food sciences-related / Hygiene / Risk sciences of radiation/Chemicals
Keywords	Principal Investigator メラノーマ / イカスミ / メラニン / RET / バイオマーカー / IBD / 炎症性腸疾患 / イカ墨 / 癌 / がん … More / アレルギー / マスト細胞 / ＩＬ－９ / IL-9 / 悪性黒色腫 / 血清プロテオーム / 転移 / プロテオミクス解析 / 疾患モデル / アルブミン / プロテオミクス / ケモカイン … More Except Principal Investigator RET / がん / チロシンキナーゼ / 酸化ストレス / 細胞老化制御 / 大豆フェリチン / メラニン / 内耳性難聴 / ラセン神経節 / 先天性難聴 / 加齢性難聴 / 感音性難聴 / 騒音性難聴 / シグナル伝達 / 遺伝子改変マウス / 感音難聴 / 騒音 / 分子標的療法 / 色素細胞 / 難聴 / 労働衛生学 / 環境ストレス / 阻害 / matrix metalloproteinase / 飲用井戸水 / アジア / 抗酸化剤 / ICP-MS / 井戸水 / 皮膚癌 / 重金属 / マレーシア / ベトナム / バングラデシュ / 国際研究者交流 / 癌遺伝子 / システイン / 癌遺伝子産物 / 発癌 / ヒ素 Less

大豆フェリチンを活用した細胞老化制御に関する基盤研究
- Principal Investigator
  
  上野有紀
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Aichi Gakuin University
活性メラニンによる炎症性腸疾患抑制メカニズムの解明Principal Investigator
- Principal Investigator
  
  川本善之
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Chubu University
Demonstration of anti-allergic and ant-tumor effects of solubilized melanin and exploration of the melanin receptorsPrincipal Investigator
- Principal Investigator
  
  Kawamoto Yoshiyuki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Health science and related fields
- Research Institution
  Chubu University
Development of molecular targeted therapy for thyroid cancer using tyrosine kinase inhibition with a novel mechanism of action
- Principal Investigator
  
  Takeda Kozue
- Project Period (FY)
  2015 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Chubu University
Analysis of anti-tumor activity of interleukin-9 in melanoma models.Principal Investigator
- Principal Investigator
  
  KAWAMOTO Yoshiyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Chubu University
Novel mechanism and molecular targeted therapy of thyroid cancer
- Principal Investigator
  
  TAKEDA Kozue
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Chubu University
Exploration of disease-related proteins from spontaneous model of melanoma by proteomics analysisPrincipal Investigator
- Principal Investigator
  
  KAWAMOTO Yoshiyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Chubu University
Analysis of arsenic-mediated carcinogenesis and development of a preventive therapy targeting modulation for three-dimensional structure of oncogene products.
- Principal Investigator
  
  KATO Masashi
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagoya University
  Chubu University
Utilization of spontaneous melanoma mice for finding biomarkersPrincipal Investigator
- Principal Investigator
  
  KAWAMOTO Yoshiyuki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Chubu University
Development of preventive therapy of no-se-induced hearing loss through clarifying its mechanism
- Principal Investigator
  
  KATO MASASHI (KATO Masashi)
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Chubu University

All 2023 2022 2021 2020 2019 2018 2017 2015 2014 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action.2020
- Author(s)
  Takeda K, Kawamoto Y, Nagasaki Y, Okuno Y, Goto Y, Iida M, Yajima I, Ohgami N, Kato M.
- Journal Title
  
  Am J Cancer Res.
  
  Volume: 10 Pages: 336-349
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10076
[Journal Article] Inhibition of mast cell degranulation by melanin.2019
- Author(s)
  Kawamoto Y, Kondo H, Hasegawa M, Kurimoto C, Ishii Y, Kato C, Botei T, Shinya M, Murate T, Ueno Y, Kawabe M, Goto Y, Yamamoto R, Iida M, Yajima I, Ohgami N, Kato M, Takeda K.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 163 Pages: 178-193
- DOI
  10.1016/j.bcp.2019.02.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09025, KAKENHI-PROJECT-17K19935, KAKENHI-PROJECT-17KT0033, KAKENHI-PROJECT-19K06464, KAKENHI-PROJECT-16K10152, KAKENHI-PROJECT-15H01743, KAKENHI-PROJECT-15H02588, KAKENHI-PROJECT-19H01147
[Journal Article] Commentary to Pastore et al (2014): Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors2014
- Author(s)
  K. Takeda, Y. Kawamoto, M. Iida, Y. Omata, C. Zou, M. Kato
- Journal Title
  
  Arch Toxicol
  
  Volume: 88 Issue: 12 Pages: 2319-2320
- DOI
  10.1007/s00204-014-1373-9
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24108002, KAKENHI-PROJECT-24406002, KAKENHI-PROJECT-24591919, KAKENHI-PROJECT-25461717
[Journal Article] Actin-binding protein, espin: a novel metastatic regulator for melanoma.2014
- Author(s)
  Yanagishita, T., Yajima, I., Kumasaka, M., Kawamoto, Y., Tsuzuki, T., Matsumoto, Y., Watanabe, D., and Kato, M.
- Journal Title
  
  Molecular cancer research
  
  Volume: 12 Pages: 440-446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430096
[Journal Article] RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy.2012
- Author(s)
  Ya manoshita O Kato M
- Journal Title
  
  Dermatol Res Pract.
  
  Volume: 2012 Pages: 354191-354191
- DOI
  10.1155/2012/354191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590558, KAKENHI-PROJECT-22700457, KAKENHI-PROJECT-22780128, KAKENHI-PROJECT-22791041, KAKENHI-PROJECT-23650241
[Journal Article] Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury2011
- Author(s)
  A. Furukawa, Y. Kawamoto, Y. Chiba, S.Takei, S. Hasegawa-Ishii, N. Kawamura, K. Yoshikawa, M. Hosokawa, S. Oikawa, M. Kato, A. Shimada
- Journal Title
  
  Neurobiology of disease
  
  Volume: 43 Issue: 3 Pages: 706-714
- DOI
  10.1016/j.nbd.2011.05.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700457, KAKENHI-PROJECT-23390162, KAKENHI-PROJECT-23650241, KAKENHI-PROJECT-23500436
[Journal Article] Molecular Network Associated with MITF in Skin Melanoma Development and Progression.2011
- Author(s)
  Ya manoshita O Kato M
- Journal Title
  
  J Skin Cancer.
  
  Volume: 2011 Pages: 730170-730170
- DOI
  10.1155/2011/730170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590558, KAKENHI-PROJECT-22700457, KAKENHI-PROJECT-22770008, KAKENHI-PROJECT-22780128, KAKENHI-PROJECT-22791041, KAKENHI-PROJECT-23590371, KAKENHI-PROJECT-23650241
[Journal Article] Control of genetically prescribed protein tyrosine kinase activities by environment-linked redox reactions2011
- Author(s)
  I. Nakashima, Y. Kawamoto, K. Takeda, M.Kato
- Journal Title
  
  Enzyme research
  
  Volume: 2011 Pages: 896567-896567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700457
[Journal Article] Protective role of Gipie,a Girdin family protein,in endoplasmic reticulum stress responses in endothelial cells2011
- Author(s)
  E. Matsushita, N. Asai, A. Enomoto, Y.Kawamoto, T. Kato, S. Mii, K. Maeda, R. Shibata, S. Hattori, M. Hagikura, K. Takahashi, M. Sokabe, Y. Murakumo, T. Murohara, M. Takahashi
- Journal Title
  
  Molecular biology of the cell
  
  Volume: 22 Pages: 736-747
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21289099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700457
[Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation.2010
- Author(s)
  Kato M, Takeda K, Hossain K, Thang ND, Kaneko Y, Kumasaka M, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y.
- Journal Title
  
  J Cell Biochem. 110(2)
  
  Pages: 399-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700371
[Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation2010
- Author(s)
  M. Kato, K. Takeda, K. Hossain, N.D.Thang, Y. Kaneko, M. Kumasaka, O. Yamanoshita, N. Uemura, M. Takahashi, N. Ohgami, Y. Kawamoto
- Journal Title
  
  Journal of cellular biochemistry
  
  Volume: 110 Issue: 2 Pages: 399-407
- DOI
  10.1002/jcb.22550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700457
[Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation.2010
- Author(s)
  Kato M, Takeda K, Hossain K, Thang D.N., Kaneko Y, Kumasaka M, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y.
- Journal Title
  
  J Cell Biochem 110
  
  Pages: 399-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20406003
[Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation.2010
- Author(s)
  Kato M, Takeda K, Hossain K, Thang D. Nguyen, Kaneko Y, Kumasaka M, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y.
- Journal Title
  
  J Cell Biochem
  
  Volume: 110 Pages: 399-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20406003
[Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation.2010
- Author(s)
  Kato M, Takeda K, Hossain K, Thang D.Nguyen, Kaneko Y, Kumasaka M,Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y
- Journal Title
  
  J Cell Biochem 110
  
  Pages: 399-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390168
[Journal Article] 1,4-butanediyl- bismethanethiosulfonate (BMTS) induces reactive oxygen species-mediated apoptotic signals independent of stress-activated MAPK cascade in Jurkat cells.2009
- Author(s)
  Hossain K, Kawamoto Y, Hamada M, Akhand A, Yanagishita T, Hoque Md. A, Tsuboi H, Kato M, Nakashima I
- Journal Title
  
  J Cell Biochem
  
  Volume: 108(5) Pages: 1059-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20406003
[Journal Article] 1, 4-butanediyl-bismethanethiosulfonate (BMTS) induces apoptosis through reactive oxygen species-mediated mechanism.2009
- Author(s)
  Hossain K, Kawamoto Y, Hamada M, Akh, AA, Yanagishita T, Hoque MA, Tsuboi H, Kato M, Nakashima I.
- Journal Title
  
  J Cell Biochem. 108(5)
  
  Pages: 1059-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700371
[Presentation] DSS誘導性炎症性腸疾患モデルを用いたメラニン及び微粒子化イカスミの炎症抑制効果と作用機序の解析2023
- Author(s)
  大下潤平, 武田湖州恵, 川本善之
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07055
[Presentation] Analysis of the suppression mechanism of inflammatory bowel disease by melanin2022
- Author(s)
  大下潤平, 古橋由唯, 武田湖州恵, 川本善之
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07055
[Presentation] 合成メラニンによる細胞増殖抑制作用の分子機構解析2021
- Author(s)
  古橋由唯, 武田湖州恵, 川本善之
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07055
[Presentation] Analysis of cancer cell growth suppression and mechanism by synthetic melanin2019
- Author(s)
  Yoshiyuki Kawamoto, Kozue Takeda
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-17K19935
[Presentation] イカスミおよび合成メラニンによるマスト細胞活性化の抑制機序解析2019
- Author(s)
  川本善之、伊藤ななみ、鈴木里歩、高井夢花、林夏希、上野有紀、武田湖州恵
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-17K19935
[Presentation] システインを介したRETキナーゼの活性阻害2019
- Author(s)
  武田湖州恵、川本善之、坂川久仁子、川添健司、矢嶋伊知朗、大神信孝、加藤昌志
- Organizer
  第89回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-15K10076
[Presentation] 合成メラニンによるがん細胞増殖および遊走の抑制2018
- Author(s)
  川本善之、近藤紘本、小森光華、大西新一郎、杉江麻友香、山野裕基、小林果、上野有紀、武田湖州恵
- Organizer
  日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K19935
[Presentation] Cell growth inhibition by solubilized eumelanin2017
- Author(s)
  Yoshiyuki Kawamoto, Kozue Takeda
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-17K19935
[Presentation] Suppression of mast cell activation by synthetic melanin2017
- Author(s)
  Hiromoto Kondo, Kozue Takeda, Yoshiyuki Kawamoto
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-17K19935
[Presentation] メラノーマ自然発症および移植モデルマウスを用いたIL-9の抗腫瘍効果の解析2015
- Author(s)
  川本善之、中山翔太、水谷直貴、村手隆、武田湖州恵
- Organizer
  BMB2015 第38回　日本分子生物学会　第88回　日本生化学会　合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25430096
[Presentation] メラノーマ自然発症RETトランスジェニックマウスを用いた腫瘍関連バイオマーカーの探索2011
- Author(s)
  川本善之
- Organizer
  第84回日本生化学会
- Place of Presentation
  国際会議場(京都)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22700457
[Presentation] チオール反応性化合物によるアポトーシス誘導とシグナル伝達機序2009
- Author(s)
  川本善之
- Organizer
  第18回日本アポトーシス研究会学術集会
- Place of Presentation
  長崎大学
- Data Source
  KAKENHI-PROJECT-19700371
[Presentation] チオール反応性化合物によるアポトーシス誘導とシグナル伝達機序2009
- Author(s)
  川本善之
- Organizer
  日本 Cell Death 学会
- Place of Presentation
  長崎大学医学部
- Year and Date
  2009-08-01
- Data Source
  KAKENHI-PROJECT-19700371
[Presentation] ヒ素による細胞膜脂質ラフトを介する活性酸素産生機序の解析2008
- Author(s)
  川本善之
- Organizer
  BMB2008
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19700371
[Presentation] メラノーマモデルマウスを用いたIL-9の抗腫瘍効果の解析
- Author(s)
  川本善之、杉野諒、長谷川まり、武田湖州恵
- Organizer
  日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都市左京区）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25430096

1. KATO Masashi (10281073)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. OHGAMI Nobutaka (80424919)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. YAMANOSHITA Osamu (50424924)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. TAKEDA Kozue (80345884)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 後藤友二 (70362522)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 上野有紀 (20388060)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 伊田みちる (80393148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 浅井直也 (80273233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 増田太郎 (40395653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TAKEDA Keigo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. OMATA Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 村手隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 飯田真智子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWAMOTO Yoshiyuki 川本 善之

Research Projects

Research Products

Co-Researchers

大豆フェリチンを活用した細胞老化制御に関する基盤研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

活性メラニンによる炎症性腸疾患抑制メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Demonstration of anti-allergic and ant-tumor effects of solubilized melanin and exploration of the melanin receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of molecular targeted therapy for thyroid cancer using tyrosine kinase inhibition with a novel mechanism of action

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of anti-tumor activity of interleukin-9 in melanoma models.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel mechanism and molecular targeted therapy of thyroid cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploration of disease-related proteins from spontaneous model of melanoma by proteomics analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of arsenic-mediated carcinogenesis and development of a preventive therapy targeting modulation for three-dimensional structure of oncogene products.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Utilization of spontaneous melanoma mice for finding biomarkersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of preventive therapy of no-se-induced hearing loss through clarifying its mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action.2020

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of mast cell degranulation by melanin.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Commentary to Pastore et al (2014): Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Actin-binding protein, espin: a novel metastatic regulator for melanoma.2014

Author(s)

KAWAMOTO Yoshiyuki 川本善之