Suzuki Takuo 鈴木琢雄

… Alternative Names

SUZUKI Takuo 鈴木琢雄

Less

Researcher Number	10415466
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 生物薬品部, 主任研究官
Affiliation (based on the past Project Information) *help	2007 – 2024: National Institute of Health Sciences, Division of Biological Chemistry and Biologicals, Senior Researcher 2015: 国立医薬品食品衛生研究所, その他部局等, 研究員 2014: 国立医薬品食品衛生研究所, 生物薬品部・第一室, 主任研究官 2013: 国立医薬品食品衛生研究所, 生物薬品部, 研究員 2010: 国立医薬品食品衛生研究所, 生物薬品部・第2室, 主任研究官 2006 – 2007: 国立医薬品食品衛生研究所, 生物薬品部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Medical pharmacy / Physical pharmacy
Keywords	Principal Investigator FcRn / 抗体医薬品 / MAPPs / 動態 / 分布 / in vitro recycling assay / 抗原提示 / Fc gamma受容体 / Fc融合タンパク質 / 抗薬物抗体 … More / ヒトFcRnトランスジェニックマウス / 体内動態 / 分解 / FcRn親和性改変抗体 / 水素重水素交換／質量分析 / HDX/MS / アミノ酸改変 / 半減期延長 / Fcγ受容体 / 表面プラズモン共鳴 / 安全性 / イメージング / FcγR / 抗原親和性 / 受容体親和性 / 薬物結合抗体（抗体薬物複合体） / 半減期 / Fc受容体 / 代謝学 / 薬物動態 … More Except Principal Investigator FcRn / 体内動態 / 血中半減期 / Fc受容体 / 抗体医薬品 / HDX/MS / 糖タンパク質 / 糖鎖 / 水素重水素交換 / 質量分析 / 相互作用解析 / 水素重水素交換／質量分析 / serum half life / protein drugs / receptor / Fc domain / タンバク質 / 医薬品 / タンパク質 / タンパク質性医薬品 / 受容体 / Fcドメイン / DC-SIGN / 半減期 / FcRn(neonatal Fc receptor) / バイオ医薬品 / TNF / FcγR / Fc融合タンパク質医薬品 Less

体内分布や抗原提示に着目したFcRn親和性改変抗体間の違いに関する研究Principal Investigator
- Principal Investigator
  
  鈴木琢雄
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  National Institute of Health Sciences
MAPPs assay to elucidate the influences of the change of FcRn affinity on the antigen presentation.Principal Investigator
- Principal Investigator
  
  Suzuki Takuo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  National Institute of Health Sciences
Influences of the change of FcRn affinity caused by antibody molecular design on pharmacokinetics.Principal Investigator
- Principal Investigator
  
  Suzuki Takuo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  National Institute of Health Sciences
Development of analytical method for glycoprotein-glycan interaction by hydrogen/deuterium exchange mass spectrometry
- Principal Investigator
  
  Hashii Noritaka
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  National Institute of Health Sciences
Basic research on neonatal Fc receptor (FcRn) affinity to establish half-life extension technology of therapeutic antibodiesPrincipal Investigator
- Principal Investigator
  
  Suzuki Takuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Health Sciences
Influence of the affinities of antibody-drug conjugates for Fc receptors and antigens on pharmacokineticsPrincipal Investigator
- Principal Investigator
  
  Suzuki Takuo
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Health Sciences
DC-SIGN as a novel Fc receptor: relationship with structure, function and immunogenicity of therapeutic antibodies
- Principal Investigator
  
  ISHII Akiko
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Health Sciences
Studies on the biodistribution, biodegradation and half-lives of Fc domain-containing proteins.Principal Investigator
- Principal Investigator
  
  SUZUKI Takuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Health Sciences
Fc receptor-related biological properties of anti-TNF therapeutics
- Principal Investigator
  
  ISHII Akiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Health Sciences
Studies on molecular basis of the pharmacokinetic regulation of protein drugs consisting of immunoglobulin Fc region
- Principal Investigator
  
  KAWANISHI Toru
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Health Sciences

[Book] バイオ医薬品の品質管理戦略第２版、第7章-1 薬物動態と品質特性2020
- Author(s)
  鈴木琢雄、石井明子
- Total Pages
  15
- Publisher
  株式会社じほう
- ISBN
  9784840752329
- Data Source
  KAKENHI-PROJECT-18K06776
[Book] バイオ医薬品の品質・安全性評価シリーズ、バイオ医薬品の生物学的性質・免疫化学的性質解析の現状、Pharm Tech Japan2012
- Author(s)
  鈴木琢雄、多田稔、石井明子
- Data Source
  KAKENHI-PROJECT-21790172
[Book] バイオ医薬品の品質・安全性に関する最近の話題-バイオ医薬品の開発、製造、及び臨床試験の安全性確保における特性理解の重要性-レギュラトリーサイエンス学会誌2012
- Author(s)
  中澤志織,橋井則貴,鈴木琢雄,多田稔,石井明子,川崎ナナ
- Data Source
  KAKENHI-PROJECT-21790172
[Book] 先端バイオ医薬品の評価技術第9章「バイオ医薬品の特性解析」2010
- Author(s)
  鈴木琢雄、多田稔、石井明子
- Publisher
  生物学的性質解析株式会社シーエムシー出版,東京
- Data Source
  KAKENHI-PROJECT-20590167
[Book] 生物学的性質解析および免疫学的性質解析、先端バイオ医薬品の評価技術第9章-32010
- Author(s)
  鈴木琢雄、多田稔、石井明子
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-21790172
[Book] 先端バイオ医薬品の評価技術第9章「バイオ医薬品の特性解析」3 生物学的性質解析2010
- Author(s)
  鈴木琢雄、多田稔、石井明子
- Total Pages
  15
- Publisher
  株式会社シーエムシー出版,東京
- Data Source
  KAKENHI-PROJECT-20590167
[Journal Article] FcRn等のFc受容体との親和性に着目した抗体エンジニアリング2023
- Author(s)
  鈴木琢雄
- Journal Title
  
  Farumashia
  
  Volume: 59 Issue: 10 Pages: 908-913
- DOI
  10.14894/faruawpsj.59.10_908
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-21K06705
[Journal Article] 第1土曜特集抗体医薬の進歩と課題リード抗体取得･エンジニアリング技術【IgG型抗体】抗体の体内動態制御に関わる受容体FcRnをめぐる話題2023
- Author(s)
  鈴木琢雄、石井明子
- Journal Title
  
  医学のあゆみ
  
  Volume: 285 Issue: 10 Pages: 875-879
- DOI
  10.32118/ayu28510875
- ISSN
  0039-2359
- Year and Date
  2023-06-03
- Data Source
  KAKENHI-PROJECT-21K06705
[Journal Article] The influence of antibody engineering on Fc conformation and Fc receptor-binding properties: analysis of FcRn-binding engineered antibodies and an Fc fusion protein2021
- Author(s)
  Takuo Suzuki, Noritaka Hashii, Minoru Tada and Akiko Ishii-Watabe
- Journal Title
  
  mAbs
  
  Volume: - Issue: 1
- DOI
  10.1080/19420862.2021.1923366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06776
[Journal Article] Nonclinical Evaluation of Next-generation Therapeutic Monoclonal Antibodies2015
- Author(s)
  石井明子，多田稔，鈴木琢雄，川崎ナナ
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 135 Issue: 7 Pages: 857-866
- DOI
  10.1248/yakushi.15-00007-3
- NAID
  130005085757
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2015-07-01
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590229
[Journal Article] A fluorescent imaging method for analyzing the biodistribution of therapeutic monoclonal antibodies that can distinguish intact antibodies from their breakdown products.2015
- Author(s)
  Takuo Suzuki, Chihiro Miyazaki, Akiko Ishii-Watabe, Minoru Tada, Kumiko Sakai-Kato, Toru Kawanishi, and Nana Kawasaki
- Journal Title
  
  mAbs
  
  Volume: 未定 Issue: 4 Pages: 759-769
- DOI
  10.1080/19420862.2015.1038683
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590229
[Journal Article] Enrichment of O-GlcNAc-modified peptides using novel thiol-alkyne and thiol-disulfide exchange2015
- Author(s)
  Tsumoto H, Ogasawara D, Hashii N, Suzuki T, Akimoto Y, Endo T, Miura Y.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 25 Pages: 2645-2649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07916
[Journal Article] 抗体医薬品の分子設計2014
- Author(s)
  石井明子，鈴木琢雄，多田稔，川崎ナナ
- Journal Title
  
  薬剤学
  
  Volume: 74 Pages: 1-8
- NAID
  130004626423
- Data Source
  KAKENHI-PROJECT-23590214
[Journal Article] バイオ医薬品の生物学的性質・免疫化学的性質解析の現状2012
- Author(s)
  鈴木琢雄、多田稔、石井明子
- Journal Title
  
  Pharm Tech Japan
  
  Volume: 28(1) Pages: 57-64
- Data Source
  KAKENHI-PROJECT-23590214
[Journal Article] バイオ医薬品の品質・安全性評価シリーズ、バイオ医薬品の生物学的性質・免疫化学的性質解析の現状2012
- Author(s)
  鈴木琢雄
- Journal Title
  
  Pharm Tech Japan
  
  Volume: 28 Pages: 57-64
- Data Source
  KAKENHI-PROJECT-21790172
[Journal Article] 抗体医薬品の体内動態制御に関わる受容体2010
- Author(s)
  石井明子、鈴木琢雄、多田稔、川西徹、山口照英、川崎ナナ
- Journal Title
  
  FcRn日本薬理学会誌 136(5)
  
  Pages: 280-4
- Data Source
  KAKENHI-PROJECT-20590167
[Journal Article] Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis.2010
- Author(s)
  Akiko Ishii-Watabe, Yoshiro Saito, Takuo Suzuki, Minoru Tada, Maho Ukaji, Keiko Maekawa, Kouichi Kurose, Nahoko Kaniwa, Jun-ichi Sawada, Nana Kawasaki, Teruhide Yamaguchi, Takako Eguchi Nakajima, Ken Kato, Yasuhide Yamada, Yasuhiro Shimada, Teruhiko Yoshida, Takashi Ura, Miyuki Saito, Kei Muro, Toshihiko Doi, Nozomu Fuse, Takayuki Yoshino, Atsushi Ohtsu, Nagahiro Saijo, Tetsuya Hamaguchi , Haruhiro Okuda, Yasuhiro Matsumura
- Journal Title
  
  Drug Metab.Pharmacokinet.
  
  Volume: 25(6) Pages: 578-587
- NAID
  10027743901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590167
[Journal Article] Importance of FcRn in regulating the serum half-life of thera peutic proteins containing the Fc domain of human IgG1 : A comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human FcRn2010
- Author(s)
  Takuo Suzuki, Akiko Ishii-Watabe, Minoru Tada, Tetsu Kobayashi, Toshie Kanayasu-Toyoda, Toru Kawanishi, Teruhide Yamaguchi
- Journal Title
  
  J.Immunol. 184(4)
  
  Pages: 1968-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590167
[Journal Article] 抗体医薬品の体内動態制御に関わる受容体2010
- Author(s)
  石井明子、鈴木琢雄、多田稔、川西徹、山口照英、川崎ナナ
- Journal Title
  
  FcRn日本薬理学会誌
  
  Volume: 136(5) Pages: 280-4
- URL
  http://dx.doi.org/10.1254/fpj.136.280
- Data Source
  KAKENHI-PROJECT-21790172
[Journal Article] Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1 : A comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR2010
- Author(s)
  Suzuki T, Ishii-Watabe A, Tada M, Kobayashi T, Kanayasu-Toyoda T, Kawanishi T, and Yamaguchi T
- Journal Title
  
  J. Immunol
  
  Volume: 184 Issue: 4 Pages: 1968-76
- DOI
  10.4049/jimmunol.0903296
- Data Source
  KAKENHI-PROJECT-21790172
[Journal Article] Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis2010
- Author(s)
  Ishii-Watabe A, Saito Y, Suzuki T, Tada M, Ukaji M, Maekawa K, Kurose K, Kaniwa N, Sawada JI, Kawasaki N, Yamaguchi T, Eguchi Nakajima T, Kato K, Yamada Y, Shimada Y, Yoshida T, Ura T, Saito M, Muro K, Doi T, Fuse N, Yoshino T, Ohtsu A, Saijo N, Hamaguchi
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 25 Pages: 578-587
- NAID
  10027743901
- URL
  http://dx.doi.org/10.2133/dmpk.DMPK-10-RG-067
- Data Source
  KAKENHI-PROJECT-21790172
[Journal Article] 抗体医薬品の体内動態制御に関わる受容体 : FcRn2010
- Author(s)
  石井明子、鈴木琢雄、多田稔、川西徹、山口照英、川崎ナナ
- Journal Title
  
  日本薬理学会誌
  
  Volume: 136(5) Pages: 280-284
- NAID
  10029416897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590167
[Journal Article] Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis.2010
- Author(s)
  Ishii-Watabe A, Saito Y, Suzuki T, Tada M, Ukaji M, Maekawa K, Kurose K, Kaniwa N, Sawada J, Kawasaki N, Yamaguchi T, Nakajima TE, Kato K, Yamada Y, Shimada Y, Yoshida T, Ura T, Saito M, Muro K, Doi T, Fuse N, Yoshino T, Ohtsu A, Saijo N, Hamaguchi T, Okuda H, Matsumura Y
- Journal Title
  
  Drug Metab.Pharmacokinet. 25(6)
  
  Pages: 578-587
- NAID
  10027743901
- Data Source
  KAKENHI-PROJECT-20590167
[Journal Article] Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1 : A comparative study of the affinity of monoclonal antibodies and Fe-fusion proteins to human neonatal FcR.2010
- Author(s)
  Takuo Suzuki, et al.
- Journal Title
  
  The Journal of Immunology 184
  
  Pages: 1968-1976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790172
[Journal Article] FcRn, a critical regulator of antibody pharmacokinetics.2010
- Author(s)
  Ishii-Watabe A, Suzuki T, Tada M, Kawanishi T, Yamaguchi T, Kawasaki N.
- Journal Title
  
  Nippon Yakurigaku Zasshi
  
  Volume: 136 Pages: 280-284
- NAID
  10029416897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790172
[Journal Article] Importance of FcRn in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1. A comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human FcRn.2010
- Author(s)
  Suzuki T, Ishii-Watabe A, Tada M, Kobayashi T, Kanayasu-Toyoda T, Kawanishi T, Yamaguchi T
- Journal Title
  
  J.Immunol. 184(4)
  
  Pages: 1968-1976
- Data Source
  KAKENHI-PROJECT-20590167
[Presentation] FcRn親和性改変抗体等のFcγ受容体結合性や高次構造に関する研究2018
- Author(s)
  鈴木琢雄、橋井則貴、多田　稔、石井明子
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-18K06776
[Presentation] 抗体のFcRn親和性改変がFcγ受容体結合性や高次構造に及ぼす影響2017
- Author(s)
  鈴木琢雄、東阪嘉子、橋井則貴、多田　稔、岩崎紀之、石井明子
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15K08087
[Presentation] 水素重水素交換／質量分析法の糖鎖―タンパク質間相互作用解析への応用2016
- Author(s)
  橋井則貴，鈴木琢雄，蛭田葉子，石井明子
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-15K07916
[Presentation] FcRn親和性の違いが抗体医薬品の体内分布などに及ぼす影響2016
- Author(s)
  鈴木琢雄、宮崎ちひろ、多田稔、橋井則貴、石井明子
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K08087
[Presentation] FcRn親和性の違いが抗体医薬品の体内分布などに及ぼす影響2016
- Author(s)
  鈴木琢雄，宮崎ちひろ，多田稔，橋井則貴，石井明子
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-24590229
[Presentation] Development of a fluorescence imaging method of therapeutic antibodies, which can distinguish degraded products from non-degraded antibodies2014
- Author(s)
  Takuo Suzuki, Chihiro Miyazaki, Akiko Ishii-Watabe, Minoru Tada, Toru Kawanishi, and Nana Kawasaki
- Organizer
  2014 AAPS annual meeting and exposition
- Place of Presentation
  米国、San Diego
- Year and Date
  2014-11-05
- Data Source
  KAKENHI-PROJECT-24590229
[Presentation] 未分解抗体と分解物の分離イメージング法の開発と抗体医薬品の生体内分布解析2014
- Author(s)
  鈴木琢雄，宮崎ちひろ，石井明子，多田稔，川崎ナナ
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590229
[Presentation] 蛍光標識抗体医薬品とその分解物の分離イメージング法2013
- Author(s)
  鈴木琢雄、宮崎ちひろ、石井明子、多田　稔、川西　徹、川崎ナナ
- Organizer
  第22回日本バイオイメージング学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590229
[Presentation] 抗体医薬品類のFcRn親和性と生体内分布に関する蛍光イメージング解析2012
- Author(s)
  鈴木琢雄
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-21790172
[Presentation] 抗体医薬品の評価科学2012
- Author(s)
  石井明子、多田稔、鈴木琢雄、川崎ナナ
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-21790172
[Presentation] 抗体医薬品の評価科学2012
- Author(s)
  石井明子、多田　稔、鈴木琢雄、川崎ナナ
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590214
[Presentation] 抗体医薬品類のFcRn親和性と生体内分布に関する蛍光イメージング解析2012
- Author(s)
  鈴木琢雄、石井明子、多田稔、宮崎ちひろ、加藤くみ子、川西徹、山口照英、奥田晴宏、川崎ナナ
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-21790172
[Presentation] 抗体医薬品類のFcRn親和性の違いと生体内分布への影響に関する研究2011
- Author(s)
  鈴木琢雄、石井明子、多田稔、宮崎ちひろ、加藤くみ子、山口照英、川西徹、川崎ナナ
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21790172
[Presentation] 複合体形成能に着目した抗TNFα抗体医薬品の生物活性評価に関する研究2011
- Author(s)
  多田稔、石井明子、鈴木琢雄、豊田淑江、川崎ナナ
- Organizer
  日本薬学会第131年会
- Data Source
  KAKENHI-PROJECT-20590167
[Presentation] 抗体医薬品類のヒトおよびマウス新生児型Fc受容体(FcRn)に対する親和性の比較2011
- Author(s)
  鈴木琢雄、石井明子、多田稔、小林哲、豊田淑江、川崎ナナ
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21790172
[Presentation] FCGRT遺伝子多型解析により見出されたNeonatal Fc receptor(FcRn)変異体の機能解析BMB20102010
- Author(s)
  多田稔、石井明子、鈴木琢雄、斎藤嘉朗、川崎ナナ
- Data Source
  KAKENHI-PROJECT-20590167
[Presentation] 抗体医薬品とFcドメイン融合タンパク質医薬品における胎児性Fc受容体(FcRn)親和性の差異に関する検討2010
- Author(s)
  鈴木琢雄,石井明子,多田稔,小林哲,豊田淑江,川西徹,山口照英
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21790172
[Presentation] 抗体医薬品とFcドメイン融合タンパク質医薬品における胎児性Fc受容体(FcRn)親和性の差異に関する検討2010
- Author(s)
  鈴木琢雄、石井明子、多田稔、小林哲、豊田淑江、川西徹、山口照英
- Organizer
  日本薬学会第130年会
- Data Source
  KAKENHI-PROJECT-20590167
[Presentation] FCGRT遺伝子多型解析により見出されたNeonatal Fc receptor(FcRn)変異体の機能解析2010
- Author(s)
  多田稔、石井明子、鈴木琢雄、斎藤嘉朗、川崎ナナ
- Organizer
  BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-20590167
[Presentation] 抗体医薬品とFcドメイン融合タンパク質医薬品における胎児性Fc受容体(FcRn)親和性の差異に関する検討2010
- Author(s)
  鈴木琢雄、石井明子、多田稔小林哲、豊田淑江、川西徹山口照英
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20590167
[Presentation] 体医薬品およびFcドメイン融合タンパク質医薬品のFc受容体(FcRnおよびFcγRI)との結合特性比較2009
- Author(s)
  鈴木琢雄、石井明子、多田稔小林哲、豊田淑江、川西徹山口照英
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20590167
[Presentation] 抗体医薬品およびFcドメイン融合タンパク質医薬品のFc受容体FcRnとの結合親和性比較2009
- Author(s)
  鈴木琢雄、石井明子、多田稔、小林哲、豊田淑江、川西徹、山口照英
- Organizer
  日本薬学会第129年会
- Data Source
  KAKENHI-PROJECT-20590167
[Presentation] 抗体医薬品およびFcドメイン融合タンパク質医薬品のFc受容体FcRnとの結合親和性比較2009
- Author(s)
  鈴木琢雄, 石井明子, 多田稔, 小林哲, 豊田淑江, 川西徹, 山口照英
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20590167
[Presentation] 抗体医薬品およびFcドメイン融合タンパク質医薬品のFc受容体(FcRnおよびFcγRI)との結合特性比較2009
- Author(s)
  鈴木琢雄,石井明子,多田稔,小林哲,豊田淑江,川西徹,山口照英
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790172
[Presentation] 抗体医薬品およびFcドメイン融合汐ンパク質医薬品のFc受容体(FcRnおよびFcγRI)との結合特性比較2009
- Author(s)
  日鈴木雅
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21790172
[Presentation] 抗体医薬品およびFcドメイン融合タンパク質医薬品のFc受容体(FcRnおよびFcγRI)との結合特性比較2009
- Author(s)
  鈴木琢雄、石井明子、多田稔、小林哲、豊田淑江、川西徹、山口照英
- Organizer
  第82回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20590167
[Presentation] 抗体医薬品およびFcドメイン融合タンパク質医薬品とFc受容体FcRnの相互作用特性解析2008
- Author(s)
  鈴木琢雄、石井明子、小林哲、豊田淑江、多田稔、川西徹、山口照英
- Organizer
  日本薬物動態学会第23回年会
- Data Source
  KAKENHI-PROJECT-20590167
[Presentation] Affinity of therapeutic monoclonal antibodies and fusion proteins to neonatal Fc receptor (FcRn)2008
- Author(s)
  鈴木琢雄, 石井明子, 小林哲, 豊田淑江, 多田稔, 川西徹, 山口照英
- Organizer
  日本薬物動態学会第23回年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20590167
[Presentation] 次世代抗体医薬品の非臨床評価
- Author(s)
  石井明子，多田稔，鈴木琢雄，川崎ナナ
- Organizer
  日本薬学会第134年会シンポジウム
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23590214

1. Hashii Noritaka (20425672)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. ISHII Akiko (50291117)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
3. TADA Minoru (50506954)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
4. KAWANISHI Toru (40124383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Suzuki Takuo 鈴木 琢雄

SUZUKI Takuo 鈴木 琢雄

Research Projects

Research Products

Co-Researchers

体内分布や抗原提示に着目したFcRn親和性改変抗体間の違いに関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

MAPPs assay to elucidate the influences of the change of FcRn affinity on the antigen presentation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Influences of the change of FcRn affinity caused by antibody molecular design on pharmacokinetics.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of analytical method for glycoprotein-glycan interaction by hydrogen/deuterium exchange mass spectrometry

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic research on neonatal Fc receptor (FcRn) affinity to establish half-life extension technology of therapeutic antibodiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Influence of the affinities of antibody-drug conjugates for Fc receptors and antigens on pharmacokineticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DC-SIGN as a novel Fc receptor: relationship with structure, function and immunogenicity of therapeutic antibodies

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the biodistribution, biodegradation and half-lives of Fc domain-containing proteins.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Fc receptor-related biological properties of anti-TNF therapeutics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on molecular basis of the pharmacokinetic regulation of protein drugs consisting of immunoglobulin Fc region

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] バイオ医薬品の品質管理戦略 第２版、第7章-1 薬物動態と品質特性2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] バイオ医薬品の品質・安全性評価シリーズ、バイオ医薬品の生物学的性質・免疫化学的性質解析の現状、Pharm Tech Japan2012

Author(s)

Data Source

[Book] バイオ医薬品の品質・安全性に関する最近の話題-バイオ医薬品の開発、製造、及び臨床試験の安全性確保における特性理解の重要性-レギュラトリーサイエンス学会誌2012

Author(s)

Data Source

[Book] 先端バイオ医薬品の評価技術第9章「バイオ医薬品の特性解析」2010

Author(s)

Publisher

Suzuki Takuo 鈴木琢雄

SUZUKI Takuo 鈴木琢雄

[Book] バイオ医薬品の品質管理戦略第２版、第7章-1 薬物動態と品質特性2020

[Book] 先端バイオ医薬品の評価技術第9章「バイオ医薬品の特性解析」3 生物学的性質解析2010

[Journal Article] 第1土曜特集抗体医薬の進歩と課題リード抗体取得･エンジニアリング技術【IgG型抗体】抗体の体内動態制御に関わる受容体FcRnをめぐる話題2023