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Futamura Manabu  二村 学

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FUTAMURA MANABU  二村 学

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Researcher Number 10415515
Other IDs
Affiliation (Current) 2025: 岐阜大学, 医学部附属病院, 教授
Affiliation (based on the past Project Information) *help 2023: 岐阜大学, 医学部附属病院, 教授
2016 – 2022: 岐阜大学, 大学院医学系研究科, 准教授
2015: 岐阜大学, 医学部, 准教授
Review Section/Research Field
Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / General surgery
Except Principal Investigator
Digestive surgery / Morphological basic dentistry
Keywords
Principal Investigator
p53 / Mieap / Mitochondria quality / in silico search / ROS / ミトコンドリア / Breast cancer / Cardiolipin / Warburg effect / ZN558 … More / PTBP1 / 乳癌・消化器癌 / Warburg効果 / Tumor suppressor / Caspase / がん代謝 / 乳がん / mieap / 乳癌 / promoter methylation / Breast Cancer / p53 … More
Except Principal Investigator
胃癌 / 薬剤感受性 / ゲノム分類 / NGS / 新臨床分類 / がんゲノム / ゲノム / Precision medicine / Precision Medicine / 癌ゲノム解析 / リポジショニング / 耐性 / 5-FU / メタボローム解析 / cDNA microarray / Thymidine phosphorylase / ヌクレオチド代謝 / 5FU耐性 / がん細胞 / 細胞・組織 / 骨転移 / リン代謝 / 骨代謝 / FGF23 / Klotho Less
  • Research Projects

    (6 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (12 People)
  •  Development of novel cancer therapy by controlling cancer metabolism of unhealthy mitochondriaPrincipal Investigator

    • Principal Investigator
      二村 学
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Gifu University
  •  Development of novel cancer therapy against ROS produced by unhealthy mitochondria in cancer cellsPrincipal Investigator

    • Principal Investigator
      Futamura Manabu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Gifu University
  •  Novel cancer therapy to target ROS from unhealthy mitochondriaPrincipal Investigator

    • Principal Investigator
      FUTAMURA MANABU
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Gifu University
  •  New classification of gastric cancer based on genome analysis for precision medicine

    • Principal Investigator
      YOSHIDA KAZUHIRO
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Gifu University
  •  The study for overcoming 5FU-resistance using drug repositioning based on mathematical information analysis

    • Principal Investigator
      mori ryutaro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Gifu University
  •  The roles of downstream factor(s) of cancer cell-derived Klotho on bone mineralization

    • Principal Investigator
      MINAMIZAKI TOMOKO
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Hiroshima University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

  • [Journal Article] Detection of high-risk patients resistant to CDK4/6 inhibitors with hormone receptor-positive HER2-negative advanced and metastatic breast cancer in Japan (KBCSG-TR-1316)2023

    • Author(s)
      Manabu Futamura, Takahiro Nakayama, Tetsuhiro Yoshinami, et al.
    • Journal Title

      Breast Cancer

      Volume: 30 Issue: 6 Pages: 943-951

    • DOI

      10.1007/s12282-023-01485-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K08046
  • [Journal Article] Mieap, a p53-Downstream Gene, Is Associated with Suppression of Breast Cancer Cell Proliferation and Better Survival2021

    • Author(s)
      Manabu Futamura, Yoshihisa Tokumaru, Kazuaki Takabe, Hirofumi Arakawa, Junichi Mase, Yoshimi Asano, Ryutaro Mori, Akira Nakakami, Kazuhiro Yoshida
    • Journal Title

      American Journal of Cancer Research

      Volume: 11 Pages: 6060-6073

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08954
  • [Journal Article] p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers2020

    • Author(s)
      Sano Hitoya、Futamura Manabu、Gaowa Siqin、Kamino Hiroki、Nakamura Yasuyuki、Yamaguchi Kazuya、Tanaka Yoshihiro、Yasufuku Itaru、Nakakami Akira、Arakawa Hirofumi、Yoshida Kazuhiro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 529 Issue: 3 Pages: 582-589

    • DOI

      10.1016/j.bbrc.2020.05.168

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07635, KAKENHI-PROJECT-20K08954, KAKENHI-PROJECT-20K20305, KAKENHI-PROJECT-19K07655
  • [Journal Article] Synthetic miR-143 Inhibits Growth of HER2-Positive Gastric Cancer Cells by Suppressing KRAS Networks Including DDX6 RNA Helicase2019

    • Author(s)
      Tokumaru Yoshihisa、Tajirika Toshihiro、Sugito Nobuhiko、Kuranaga Yuki、Shinohara Haruka、Tsujino Takuya、Matsuhashi Nobuhisa、Futamura Manabu、Akao Yukihiro、Yoshida Kazuhiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 7 Pages: 1697-1697

    • DOI

      10.3390/ijms20071697

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15273, KAKENHI-PROJECT-17H04280
  • [Journal Article] Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer.2018

    • Author(s)
      Gaowa S, Futamura M*, Tsuneki M, Kamino H, Tajima JY, Mori R, Arakawa H,
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 12 Pages: 3910-3920

    • DOI

      10.1111/cas.13824

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10542, KAKENHI-PROJECT-17H05105, KAKENHI-PROJECT-20K20305
  • [Journal Article] Precision medicine に向けたゲノム解析に基づく胃癌新分類の試み2018

    • Author(s)
      二村 学、吉田 和弘
    • Journal Title

      BIO Clinica

      Volume: 33 Pages: 549-554

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04280
  • [Presentation] 乳癌においてPTBP1発現はOncogeneとして腫瘍増殖に関与している。2023

    • Author(s)
      二村 学
    • Organizer
      第61回日本癌治療学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K08046
  • [Presentation] PTBP1 is associated with tumor proliferation as an oncogene in breast cancer.2023

    • Author(s)
      二村 学
    • Organizer
      第82回日本癌学会
    • Data Source
      KAKENHI-PROJECT-23K08046
  • [Presentation] MIEAP functions as a tumor suppressor by cooperating with PTB12022

    • Author(s)
      Manabu Futamura, Ryutaro Mori, Yoshimi Niwa, Yoshihisa Tokumaru
    • Organizer
      第81回日本癌学会
    • Data Source
      KAKENHI-PROJECT-20K08954
  • [Presentation] Mieap, a p53-downstream gene, is associated with suppression of breast cancer cell proliferation and better survival2021

    • Author(s)
      Manabu Futamura
    • Organizer
      San Antonio Breast Cancer Meeting 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08954
  • [Presentation] P53下流遺伝子Mieapは乳癌予後と関係している2021

    • Author(s)
      二村 学
    • Organizer
      第80回日本癌学会
    • Data Source
      KAKENHI-PROJECT-20K08954
  • [Presentation] Mieap, a p53-inducible gene, is associated with breast cancer prognosis.2021

    • Author(s)
      二村 学
    • Organizer
      第59回日本癌治療学会
    • Data Source
      KAKENHI-PROJECT-20K08954
  • [Presentation] Potential role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in gastric, esophageal and breast cancers2020

    • Author(s)
      Manabu Futamura
    • Organizer
      AACR 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08954
  • [Presentation] p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in upper GI cancers2020

    • Author(s)
      Manabu Futamura
    • Organizer
      第79回日本癌学会
    • Data Source
      KAKENHI-PROJECT-20K08954
  • [Presentation] Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer2019

    • Author(s)
      Manabu Futamura
    • Organizer
      an Antonio Breast cancer meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10542
  • [Presentation] Potential role of Mieap, a downstream gene of p53, and inactivation of Mieap-regulated mitochondrial quality control in breast cancer.2018

    • Author(s)
      Manabu Futamura
    • Organizer
      第56回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K10542
  • [Presentation] p53下流遺伝子Mieapの乳癌における発現異常とその意義について2018

    • Author(s)
      二村 学
    • Organizer
      第24回日本乳癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K10542
  • [Presentation] p53下流遺伝子Mieapの乳腺腫瘍における発現とその意義について2018

    • Author(s)
      二村 学
    • Organizer
      日本乳癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K10542
  • 1.  YOSHIDA KAZUHIRO (50230727)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 2.  MINAMIZAKI TOMOKO (30452593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  YOSHIKO YUJI (20263709)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  KOZAI KATSUYUKI (10178212)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  mori ryutaro (00738635)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  奥田 修二郎 (00512310)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  大島 貴 (10448665)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  北川 雄光 (20204878)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  沖 英次 (70380392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  Tajima Jesse Yu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KAMINO Hiroki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  篠原 悠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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