Futamura Manabu 二村学

… Alternative Names

FUTAMURA MANABU 二村学

Less

Researcher Number	10415515
Other IDs
Affiliation (Current)	2025: 岐阜大学, 医学部附属病院, 教授
Affiliation (based on the past Project Information) *help	2023: 岐阜大学, 医学部附属病院, 教授 2016 – 2022: 岐阜大学, 大学院医学系研究科, 准教授 2015: 岐阜大学, 医学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / General surgery Except Principal Investigator Digestive surgery / Morphological basic dentistry
Keywords	Principal Investigator p53 / Mieap / Mitochondria quality / in silico search / ROS / ミトコンドリア / Breast cancer / Cardiolipin / Warburg effect / ZN558 … More / PTBP1 / 乳癌・消化器癌 / Warburg効果 / Tumor suppressor / Caspase / がん代謝 / 乳がん / mieap / 乳癌 / promoter methylation / Breast Cancer / ｐ５３ … More Except Principal Investigator 胃癌 / 薬剤感受性 / ゲノム分類 / NGS / 新臨床分類 / がんゲノム / ゲノム / Precision medicine / Precision Medicine / 癌ゲノム解析 / リポジショニング / 耐性 / 5-FU / メタボローム解析 / cDNA microarray / Thymidine phosphorylase / ヌクレオチド代謝 / 5FU耐性 / がん細胞 / 細胞・組織 / 骨転移 / リン代謝 / 骨代謝 / FGF23 / Klotho Less

Development of novel cancer therapy by controlling cancer metabolism of unhealthy mitochondriaPrincipal Investigator
- Principal Investigator
  
  二村学
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Gifu University
Development of novel cancer therapy against ROS produced by unhealthy mitochondria in cancer cellsPrincipal Investigator
- Principal Investigator
  
  Futamura Manabu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Gifu University
Novel cancer therapy to target ROS from unhealthy mitochondriaPrincipal Investigator
- Principal Investigator
  
  FUTAMURA MANABU
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Gifu University
New classification of gastric cancer based on genome analysis for precision medicine
- Principal Investigator
  
  YOSHIDA KAZUHIRO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Gifu University
The study for overcoming 5FU-resistance using drug repositioning based on mathematical information analysis
- Principal Investigator
  
  mori ryutaro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Gifu University
The roles of downstream factor(s) of cancer cell-derived Klotho on bone mineralization
- Principal Investigator
  
  MINAMIZAKI TOMOKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hiroshima University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Detection of high-risk patients resistant to CDK4/6 inhibitors with hormone receptor-positive HER2-negative advanced and metastatic breast cancer in Japan (KBCSG-TR-1316)2023
- Author(s)
  Manabu Futamura, Takahiro Nakayama, Tetsuhiro Yoshinami, et al.
- Journal Title
  
  Breast Cancer
  
  Volume: 30 Issue: 6 Pages: 943-951
- DOI
  10.1007/s12282-023-01485-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08046
[Journal Article] Mieap, a p53-Downstream Gene, Is Associated with Suppression of Breast Cancer Cell Proliferation and Better Survival2021
- Author(s)
  Manabu Futamura, Yoshihisa Tokumaru, Kazuaki Takabe, Hirofumi Arakawa, Junichi Mase, Yoshimi Asano, Ryutaro Mori, Akira Nakakami, Kazuhiro Yoshida
- Journal Title
  
  American Journal of Cancer Research
  
  Volume: 11 Pages: 6060-6073
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08954
[Journal Article] p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers2020
- Author(s)
  Sano Hitoya、Futamura Manabu、Gaowa Siqin、Kamino Hiroki、Nakamura Yasuyuki、Yamaguchi Kazuya、Tanaka Yoshihiro、Yasufuku Itaru、Nakakami Akira、Arakawa Hirofumi、Yoshida Kazuhiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 529 Issue: 3 Pages: 582-589
- DOI
  10.1016/j.bbrc.2020.05.168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07635, KAKENHI-PROJECT-20K08954, KAKENHI-PROJECT-20K20305, KAKENHI-PROJECT-19K07655
[Journal Article] Synthetic miR-143 Inhibits Growth of HER2-Positive Gastric Cancer Cells by Suppressing KRAS Networks Including DDX6 RNA Helicase2019
- Author(s)
  Tokumaru Yoshihisa、Tajirika Toshihiro、Sugito Nobuhiko、Kuranaga Yuki、Shinohara Haruka、Tsujino Takuya、Matsuhashi Nobuhisa、Futamura Manabu、Akao Yukihiro、Yoshida Kazuhiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 7 Pages: 1697-1697
- DOI
  10.3390/ijms20071697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15273, KAKENHI-PROJECT-17H04280
[Journal Article] Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer.2018
- Author(s)
  Gaowa S, Futamura M*, Tsuneki M, Kamino H, Tajima JY, Mori R, Arakawa H,
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 12 Pages: 3910-3920
- DOI
  10.1111/cas.13824
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10542, KAKENHI-PROJECT-17H05105, KAKENHI-PROJECT-20K20305
[Journal Article] Precision medicine に向けたゲノム解析に基づく胃癌新分類の試み2018
- Author(s)
  二村　学、吉田　和弘
- Journal Title
  
  BIO Clinica
  
  Volume: 33 Pages: 549-554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04280
[Presentation] 乳癌においてPTBP1発現はOncogeneとして腫瘍増殖に関与している。2023
- Author(s)
  二村　学
- Organizer
  第61回日本癌治療学会学術総会
- Data Source
  KAKENHI-PROJECT-23K08046
[Presentation] PTBP1 is associated with tumor proliferation as an oncogene in breast cancer.2023
- Author(s)
  二村　学
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-23K08046
[Presentation] MIEAP functions as a tumor suppressor by cooperating with PTB12022
- Author(s)
  Manabu Futamura, Ryutaro Mori, Yoshimi Niwa, Yoshihisa Tokumaru
- Organizer
  第81回日本癌学会
- Data Source
  KAKENHI-PROJECT-20K08954
[Presentation] Mieap, a p53-downstream gene, is associated with suppression of breast cancer cell proliferation and better survival2021
- Author(s)
  Manabu Futamura
- Organizer
  San Antonio　Breast Cancer Meeting　2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08954
[Presentation] P53下流遺伝子Mieapは乳癌予後と関係している2021
- Author(s)
  二村　学
- Organizer
  第80回日本癌学会
- Data Source
  KAKENHI-PROJECT-20K08954
[Presentation] Mieap, a p53-inducible gene, is associated with breast cancer prognosis.2021
- Author(s)
  二村　学
- Organizer
  第59回日本癌治療学会
- Data Source
  KAKENHI-PROJECT-20K08954
[Presentation] Potential role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in gastric, esophageal and breast cancers2020
- Author(s)
  Manabu Futamura
- Organizer
  AACR 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08954
[Presentation] p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in upper GI cancers2020
- Author(s)
  Manabu Futamura
- Organizer
  第79回日本癌学会
- Data Source
  KAKENHI-PROJECT-20K08954
[Presentation] Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer2019
- Author(s)
  Manabu Futamura
- Organizer
  an Antonio Breast cancer meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10542
[Presentation] Potential role of Mieap, a downstream gene of p53, and inactivation of Mieap-regulated mitochondrial quality control in breast cancer.2018
- Author(s)
  Manabu Futamura
- Organizer
  第56回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10542
[Presentation] p53下流遺伝子Mieapの乳癌における発現異常とその意義について2018
- Author(s)
  二村　学
- Organizer
  第24回日本乳癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10542
[Presentation] p53下流遺伝子Mieapの乳腺腫瘍における発現とその意義について2018
- Author(s)
  二村　学
- Organizer
  日本乳癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10542

1. YOSHIDA KAZUHIRO (50230727)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. MINAMIZAKI TOMOKO (30452593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YOSHIKO YUJI (20263709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KOZAI KATSUYUKI (10178212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. mori ryutaro (00738635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 奥田修二郎 (00512310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 大島貴 (10448665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 北川雄光 (20204878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 沖英次 (70380392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Tajima Jesse Yu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAMINO Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 篠原悠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Futamura Manabu 二村 学

FUTAMURA MANABU 二村 学

Research Projects

Research Products

Co-Researchers

Development of novel cancer therapy by controlling cancer metabolism of unhealthy mitochondriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel cancer therapy against ROS produced by unhealthy mitochondria in cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel cancer therapy to target ROS from unhealthy mitochondriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New classification of gastric cancer based on genome analysis for precision medicine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study for overcoming 5FU-resistance using drug repositioning based on mathematical information analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The roles of downstream factor(s) of cancer cell-derived Klotho on bone mineralization

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Detection of high-risk patients resistant to CDK4/6 inhibitors with hormone receptor-positive HER2-negative advanced and metastatic breast cancer in Japan (KBCSG-TR-1316)2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mieap, a p53-Downstream Gene, Is Associated with Suppression of Breast Cancer Cell Proliferation and Better Survival2021

Author(s)

Journal Title

Data Source

[Journal Article] p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthetic miR-143 Inhibits Growth of HER2-Positive Gastric Cancer Cells by Suppressing KRAS Networks Including DDX6 RNA Helicase2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Precision medicine に向けたゲノム解析に基づく胃癌新分類の試み2018

Author(s)

Journal Title

Data Source

[Presentation] 乳癌においてPTBP1発現はOncogeneとして腫瘍増殖に関与している。2023

Author(s)

Organizer

Data Source

[Presentation] PTBP1 is associated with tumor proliferation as an oncogene in breast cancer.2023

Author(s)

Organizer

Data Source

[Presentation] MIEAP functions as a tumor suppressor by cooperating with PTB12022

Author(s)

Organizer

Futamura Manabu 二村学

FUTAMURA MANABU 二村学