CHE Xiao-fang 車暁芳

Researcher Number	10437973
Other IDs	https://orcid.org/0000-0002-9087-1007
Affiliation (based on the past Project Information) *help	2014: 東京医科大学, 医学部, 助教 2010: Tokyo Medical University, 医学部, 助教 2007 – 2009: Kagoshima University, 大学院・医歯学総合研究科, 助教
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Tumor therapeutics Except Principal Investigator Pathological medical chemistry
Keywords	Principal Investigator XIAP / survivin / ATL / Survivin / 分子標的治療 / apoptosis / surviving / dimer / sodium arsenite / NF-κB … More Except Principal Investigator … More ストレス / P38 / アポトーシス / PTEN / ARK / 高浸透圧 / Akt / PI3K / osmotic stress / LRP / Vault / MVP Less

SurvivinとXIAPの相互作用を標的とする成人T細胞白血病の新規治療法開発Principal Investigator
- Principal Investigator
  
  車暁芳
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokyo Medical University
development of survivin targeted therapy for Adult T-cell leukemia/lymphomaPrincipal Investigator
- Principal Investigator
  
  CHE Xiao-Fang
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Medical University
  Kagoshima University
Analysis of physiological function of vaults
- Principal Investigator
  
  AKIYAMA Shinichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagoshima University
The mechanism of suppression of NF-κB activity and survivin expression by sodium arsenite in ATL cellsPrincipal Investigator
- Principal Investigator
  
  CHE Xiao-fang
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagoshima University

All 2015 2011 2010 2008 2007 Other

All Journal Article Presentation

[Journal Article] Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress-mediated cell death in multiple myeloma cells.2015
- Author(s)
  Moriya S, Komatsu S, Yamasaki K, Kawai Y, Kokuba H, Hirota A, Che XF, Inazu M, Gotoh A, Hiramoto M, Miyazawa K
- Journal Title
  
  Int J Oncol.
  
  Volume: Feb;46(2) Issue: 2 Pages: 474-86
- DOI
  10.3892/ijo.2014.2773
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-26430170, KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-26670589, KAKENHI-PROJECT-15K07972
[Journal Article] Rapid decrease of intracellular pH associated with inhibition of Na+/H+ exchanger precedes apoptotic events in the MNK45 and MNK74 gastric cancer cell lines treated with 2-aminophenoxazine-3-one.2011
- Author(s)
  Nagata H, Che X-F.
- Journal Title
  
  Oncol Rep. 25
  
  Pages: 341-346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790324
[Journal Article] 2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells.2011
- Author(s)
  Che X-F, Zheng C-L, Akiyama S, Tomoda A.
- Journal Title
  
  Pro.Jpn.Acad., Ser.B. 87
  
  Pages: 199-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790324
[Journal Article] 2-aminophenoxazine-3-one and 2-amino-4, 4α-dihydro-4α, 7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells2011
- Author(s)
  Xiao-Fang Che
- Journal Title
  
  Proc.Jpn.Acad., Ser.B
  
  Volume: 87 Pages: 199-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790324
[Journal Article] Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells : crosstalk among proteasome, autophagy-lysosome and ER stress.2011
- Author(s)
  Kawaguchi T, Che X-F.
- Journal Title
  
  Int J Oncol. 38
  
  Pages: 643-654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790324
[Journal Article] 2-Aminophenoxazine-3-one induces cellular apoptosis by causing rapid intracellular acidification and generating reactive oxygen species in human lung adenocarcinoma cells.2010
- Author(s)
  Zheng C-L, Che X-F.
- Journal Title
  
  Int J Oncol. 36
  
  Pages: 641-650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790324
[Journal Article] The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells.2010
- Author(s)
  Matsushita S, Che X-F.
- Journal Title
  
  Int J Oncol. 36
  
  Pages: 1193-2000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790324
[Journal Article] Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives.2008
- Author(s)
  Xiao-Fang Che
- Journal Title
  
  Oncol Rep. 19
  
  Pages: 1253-1258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives2008
- Author(s)
  Che X-F, Akiyama S, Tomoda A
- Journal Title
  
  Oncol Rep 19
  
  Pages: 1253-1258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790239
[Journal Article] Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives2008
- Author(s)
  Xiao-Fang Che
- Journal Title
  
  Oncol Rep 19
  
  Pages: 1253-1258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790239
[Journal Article] Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU.2008
- Author(s)
  Zhao H-Y, Che X-F(他13名8番目)
- Journal Title
  
  Cancer Res. 68
  
  Pages: 7035-7041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790239
[Journal Article] Apoptosis induction preceded by mitochondrial depolarization in multiple myeloma cell line U266 by 2-aminophenoxazine-3-one2008
- Author(s)
  Shirato K, Che X-F(他6人6番目)
- Journal Title
  
  Biol Pharm Bull 31
  
  Pages: 62-67
- NAID
  110006569975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790239
[Journal Article] Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in KM12C cells2008
- Author(s)
  Zhao H-Y, Che X-F, Akiyama S(他12名)
- Journal Title
  
  Cancer Lett. 270
  
  Pages: 156-163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Hyperosmotic Stress Up-regulates the Expression of Major Vault Protein in SW620 Human Colon Cancer Cells2008
- Author(s)
  Ikeda R, Che X-F(他17名10番目)
- Journal Title
  
  Exp. Cell Res. 314
  
  Pages: 3017-3026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790239
[Journal Article] Thymidine phosphorylase inhibits the expression of proapoptic protein BNIP32008
- Author(s)
  Ikeda R, Che X-F(他14名4番目)
- Journal Title
  
  Biochem Biophys Res Commun. 370
  
  Pages: 220-224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790239
[Journal Article] Hyperosmotic Stress Up-regulates the Expression of Major Vault Protein in SW620 Human Colon Cancer Cells. Exp2008
- Author(s)
  Ikeda R, Che X-F, Akiyama S(他16名)
- Journal Title
  
  Cell Res 314
  
  Pages: 3017-3026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU2008
- Author(s)
  Zhao H-Y, Che X-F, Akiyama S(他12名)
- Journal Title
  
  Cancer Res 68
  
  Pages: 7035-7041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives2008
- Author(s)
  Che X-F, Akiyama S, Tomoda A
- Journal Title
  
  Oncol Rep 19
  
  Pages: 1253-1258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Thymidine phosphorylase inhibits the expression of proapoptic protein BNIP32008
- Author(s)
  Ikeda R, Che X-F, Akiyama S(他13名)
- Journal Title
  
  Biochem Biophys Res Commun 370
  
  Pages: 220-224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in KM12C cells.2008
- Author(s)
  Zhao H-Y, Che X-F(他13名8番目)
- Journal Title
  
  Cancer Lett. 270
  
  Pages: 156-163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790239
[Journal Article] Apoptosis induction preceded by mitochondrial depolarization in multiple myeloma cell line U266 by 2-aminophenoxazine-3-one2008
- Author(s)
  Shirato K, Che X-F, Akiyama S(他5人)
- Journal Title
  
  Biol Pharm Bull 31
  
  Pages: 62-67
- NAID
  110006569975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer.2007
- Author(s)
  Owatari S, Che X-F(他13人中6番目)
- Journal Title
  
  Cancer Res. 67
  
  Pages: 4860-4868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790239
[Journal Article] Isolation and characterization of arsenite-resistant human epidermoid carcinoma KB cells2007
- Author(s)
  Tachiwada T, Che X-F(他11人3番目)
- Journal Title
  
  Oncol Rep 18
  
  Pages: 721-727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790239
[Journal Article] Isolation and characterization of arsenite-resistant human epidermoid carcinoma KB cells2007
- Author(s)
  Tachiwada T, Che X-F, Akiyama S(他10人)
- Journal Title
  
  Oncol Rep 18
  
  Pages: 721-727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer2007
- Author(s)
  Owatari S, Che X-F, Akiyama S(他12人中)
- Journal Title
  
  Cancer Res 67
  
  Pages: 4860-4868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives
- Author(s)
  Che X-F
- Journal Title
  
  Oncol Rep. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790239
[Journal Article] Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives
- Author(s)
  Che X-F
- Journal Title
  
  Oncol Rep (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Presentation] survivinペプチド(89-104アミノ酸)によるATL細胞のアポトーシス誘導2008
- Author(s)
  車暁芳
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19590314
[Presentation] survivinペプチド(89-104アミノ酸)によるATL細胞のアポトーシス誘導2008
- Author(s)
  車暁芳
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19790239
[Presentation] survivinペプチド(89-104アミノ酸)によるATL細胞のアポトーシス誘導2008
- Author(s)
  車暁芳
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19590314
[Presentation] survivinペプチド(89-104アミノ酸)によるATL細胞のアポトーシス誘導2008
- Author(s)
  車暁芳
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19790239
[Presentation] The effect of hypoxia on gene expression in human fibroblast WI-38 cells2007
- Author(s)
  Xiao-Fang Che
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19790239
[Presentation] The effect of hypoxia on gene expression in human fibroblast WI-38 cells2007
- Author(s)
  Xiao-Fang Che
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19590314
[Presentation] The effect of hypoxia on gene expression in human fibroblast WI-38 cells.2007
- Author(s)
  Xiao-Fang Che
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19590314
[Presentation] The effect of hypoxia on gene expression in human fibroblast WI-38 cells2007
- Author(s)
  Xiao-fang Che
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19790239

1. AKIYAMA Shinichi (60117413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 森谷昇太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

CHE Xiao-fang 車 暁芳

Research Projects

Research Products

Co-Researchers

SurvivinとXIAPの相互作用を標的とする成人T細胞白血病の新規治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

development of survivin targeted therapy for Adult T-cell leukemia/lymphomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of physiological function of vaults

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of suppression of NF-κB activity and survivin expression by sodium arsenite in ATL cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress-mediated cell death in multiple myeloma cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid decrease of intracellular pH associated with inhibition of Na+/H+ exchanger precedes apoptotic events in the MNK45 and MNK74 gastric cancer cell lines treated with 2-aminophenoxazine-3-one.2011

Author(s)

Journal Title

Data Source

[Journal Article] 2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells.2011

Author(s)

Journal Title

Data Source

[Journal Article] 2-aminophenoxazine-3-one and 2-amino-4, 4α-dihydro-4α, 7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells2011

Author(s)

Journal Title

Data Source

[Journal Article] Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells : crosstalk among proteasome, autophagy-lysosome and ER stress.2011

Author(s)

Journal Title

Data Source

[Journal Article] 2-Aminophenoxazine-3-one induces cellular apoptosis by causing rapid intracellular acidification and generating reactive oxygen species in human lung adenocarcinoma cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives.2008

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives2008

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives2008

Author(s)

Journal Title

Data Source

[Journal Article] Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU.2008

Author(s)

Journal Title

Data Source

[Journal Article] Apoptosis induction preceded by mitochondrial depolarization in multiple myeloma cell line U266 by 2-aminophenoxazine-3-one2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in KM12C cells2008

Author(s)

CHE Xiao-fang 車暁芳