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FUJIMOTO Takahiro  藤本 崇宏

… Alternative Names

TAKAHIRO Fujimoto  藤本 崇宏

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Researcher Number 10446114
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-9975-7008
Affiliation (Current) 2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
Affiliation (based on the past Project Information) *help 2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
2016 – 2023: 京都府立医科大学, 医学(系)研究科(研究院), 講師
2013 – 2015: 京都府立医科大学, 医学(系)研究科(研究院), 助教
2012: 福岡大学, 医学部, 講師
2009 – 2010: Fukuoka University, 医学部, 講師
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 51030:Pathophysiologic neuroscience-related / Pediatrics / Chemical biology / Pathological medical chemistry
Except Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords
Principal Investigator
Dp71 / ジストロフィン / リン酸化 / 分子間相互作用 / ジストログリカン / 会合蛋白 / 癌 / てんかん / 分子複合体 / シナプス … More / アストロサイト / BBB / 血液脳関門 / カリウムチャネル / 水チャネル / グリア / 小脳 / プロテオーム / 知的障がい / 筋ジストロフィー / タグ挿入マウス / 神経筋疾患 / DMD / 分子ネットワーク / 中枢神経症状 / BioID / 動物モデル / 蛋白安定化 / 蛋白相互作用 / 分子病態 / 膜局在化 / 点変異 / モデル細胞 / 分子機序 / 知的障害 / 脳神経細胞 / プロテアソーム / 蛋白分解 / バイオプローブ / 化合物 / 翻訳後修飾 / リンパ球 / カルシウムイオンシグナル / 分子標的 / 結合蛋白質 / トランスジェニックマウス / 細胞生物学 / 分子生物学 / 結合蛋白 / KRAP … More
Except Principal Investigator
脳オルガノイド / 神経幹・前駆細胞 / 脳形成異常 / 胎児医学 / 子宮内電気穿孔法 / 体細胞モザイク / 治療標的分子 / タナトフォリック骨異形成症 / 白血病阻害因子 / ヒト神経幹・前駆細胞 / 脳形成異常脳形成異常 / 繊毛病 / 一次繊毛 Less
  • Research Projects

    (8 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (5 People)
  •  マルチタグ挿入マウスによるジストロフィン短鎖産物の胎児脳時空間的プロファイリングPrincipal Investigator

    • Principal Investigator
      藤本 崇宏
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Molecular pathogenesis of brain malformations in de novo postzygotic mutations in the brain

    • Principal Investigator
      Itoh Kyoko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Functional analysis of dystrophin in blood-brain barrier and its relevance to epilepsyPrincipal Investigator

    • Principal Investigator
      Fujimoto Takahiro
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Elucidation of molecular pathomechanisms and the search for therapeutic targets of brain malformations, by employing cerebral organoids generated from patients-derived neural stem/progenitor cells

    • Principal Investigator
      Itoh Kyoko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Molecular analysis of brain-type dystrophin to understand dystrophinopahy-related neurological disorderPrincipal Investigator

    • Principal Investigator
      Fujimoto Takahiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Degradation mechanism of dystrophin short isoform, Dp71Principal Investigator

    • Principal Investigator
      Fujimoto Takahiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Analysis of the molecular interaction between KRAP and IP3R and its application for drug discoveryPrincipal Investigator

    • Principal Investigator
      FUJIMOTO Takahiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Chemical biology
    • Research Institution
      Kyoto Prefectural University of Medicine
      Fukuoka University
  •  Establishment of KRAP-transgenic mice and elucidation of KRAP function in cancerPrincipal Investigator

    • Principal Investigator
      TAKAHIRO Fujimoto
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Fukuoka University

All 2023 2022 2020 2018 2017 2016 2013 2012 2010 2009

All Journal Article Presentation Patent

  • [Journal Article] Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons2023

    • Author(s)
      Fujimoto T, Stam K, Yaoi T, Nakano K, Arai T, Okamura T, Itoh K.
    • Journal Title

      Molecular Neurobiology

      Volume: - Issue: 7 Pages: 3664-3677

    • DOI

      10.1007/s12035-023-03296-w

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07279
  • [Journal Article] Generation of dystrophin short product-specific tag-insertion mouse: distinct Dp71 glycoprotein complexes at inhibitory postsynapse and glia limitans2022

    • Author(s)
      Fujimoto Takahiro、Yaoi Takeshi、Nakano Kenta、Arai Tetsuya、Okamura Tadashi、Itoh Kyoko
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 79 Issue: 2 Pages: 109-109

    • DOI

      10.1007/s00018-022-04151-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07279
  • [Journal Article] Dystroglycan regulates proper expression, submembranous localization and subsequent phosphorylation of Dp71 through physical interaction.2020

    • Author(s)
      Fujimoto T, Yaoi T, Tanaka H, Itoh K.
    • Journal Title

      Hum Mol Genet.

      Volume: 29(19) Issue: 19 Pages: 3312-3326

    • DOI

      10.1093/hmg/ddaa217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07883
  • [Journal Article] Serotonin induces Arcadlin in hippocampal neurons2020

    • Author(s)
      Tanaka Hidekazu、Sawano Toshinori、Konishi Naoko、Harada Risako、Takeuchi Chiaki、Shin Yuki、Sugiura Hiroko、Nakatani Jin、Fujimoto Takahiro、Yamagata Kanato
    • Journal Title

      Neuroscience Letters

      Volume: 721 Pages: 134783-134783

    • DOI

      10.1016/j.neulet.2020.134783

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02536, KAKENHI-PROJECT-18K07883
  • [Journal Article] Dp71 is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells.2017

    • Author(s)
      Fujimoto T, Yaoi T, Fushiki S, Itoh K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 492(3) Issue: 3 Pages: 349-355

    • DOI

      10.1016/j.bbrc.2017.08.108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09629
  • [Journal Article] HEK293 cells express dystrophin Dp71 with nucleus-specific localization of Dp71ab.2016

    • Author(s)
      Nishida A, Yasuno S, Takeuchi A, Awano H, Lee T, Niba ET, Fujimoto T, Itoh K, Takeshima Y, Nishio H, Matsuo M.
    • Journal Title

      Histochem Cell Biol.

      Volume: 146 Issue: 3 Pages: 301-309

    • DOI

      10.1007/s00418-016-1439-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09629
  • [Journal Article] Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux.2013

    • Author(s)
      Matsuzaki H, Fujimoto T, Tanaka M, Shirasawa S.
    • Journal Title

      Biochem Bio- phys Res Commun

      Volume: 433(3) Issue: 3 Pages: 322-326

    • DOI

      10.1016/j.bbrc.2013.02.099

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390102, KAKENHI-PROJECT-24710265
  • [Journal Article] Tespa1 protein is phosphorylated in response to store-operated calcium entry.2013

    • Author(s)
      Fujimoto T, Matsuzaki H, Tanaka M, Shirasawa S.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 434 Pages: 162-165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24710265
  • [Journal Article] Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney.2012

    • Author(s)
      Fujimoto T.
    • Journal Title

      Int J Mol Med.

      Volume: 30(6) Issue: 6 Pages: 1287-1293

    • DOI

      10.3892/ijmm.2012.1126

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390102, KAKENHI-PROJECT-24710265
  • [Journal Article] Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes.2012

    • Author(s)
      Matsuzaki H, Fujimoto T, Ota T, Ogawa M, Tsunoda T, Doi K, Hamabashiri M, Tanaka M, Shirasawa S
    • Journal Title

      FEBS Open Bio

      Volume: 2 Pages: 255-259

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24710265
  • [Journal Article] Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice2009

    • Author(s)
      Takahiro Fujimoto
    • Journal Title

      PLoS ONE 4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790331
  • [Patent] イノシトール-1, 4, 5-トリスリン酸受容体結合タンパク質およびそれを含むトランスジェニック非ヒト哺乳動物2009

    • Inventor(s)
      藤本崇宏、白澤専二
    • Industrial Property Rights Holder
      学校法人福岡大学
    • Industrial Property Number
      2009-225596
    • Filing Date
      2009-09-29
    • Data Source
      KAKENHI-PROJECT-21790331
  • [Presentation] ジストロフィン分子機能の理解に立脚したデュシェンヌ型筋ジストロフィー機序解明を目指して2022

    • Author(s)
      藤本崇宏
    • Organizer
      第63回日本神経病理学会総会学術研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07279
  • [Presentation] ジストロフィン遺伝子産物Dp71の脳における役割2022

    • Author(s)
      藤本崇宏
    • Organizer
      第9回筋ジストロフィーのCNS障害研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07279
  • [Presentation] Dystrophin short isoform, Dp71, is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells2018

    • Author(s)
      T. Fujimoto, K. Itoh
    • Organizer
      11th FENS Forum of Neuroscience
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07883
  • [Presentation] Dystrophin short isoform, Dp71, is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells2018

    • Author(s)
      T. Fujimoto, T. Yaoi, S. Fushiki, K. Itoh
    • Organizer
      22nd Biennial Meeting of the International Society of Developmental Neuroscience
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07883
  • [Presentation] ジストロフィン遺伝子産物であるDp71はリン酸化とユビキチンプロテアソーム系によって発現制御される2017

    • Author(s)
      藤本崇宏、矢追毅、伏木信次、伊東恭子
    • Organizer
      第40回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-15K09629
  • [Presentation] 脳型ジストロフィンの分子病態解析に基づく知的障害治療法の探索2017

    • Author(s)
      藤本 崇宏、伊東 恭子
    • Organizer
      第120回日本小児科学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09629
  • [Presentation] 脳型ジストロフィンの分子病態解析に基づく知的障害治療法の探索2017

    • Author(s)
      藤本崇宏、伊東恭子
    • Organizer
      第120回 日本小児科学会学術集会
    • Place of Presentation
      東京・品川・グランドプリンスホテル新高輪
    • Year and Date
      2017-04-14
    • Data Source
      KAKENHI-PROJECT-15K09629
  • [Presentation] 癌・代謝関連遺伝子KRAPの細胞内カルシウムイオン制御機構に関する研究2012

    • Author(s)
      藤本崇宏、白澤専二
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24710265
  • [Presentation] 新たな肥満・糖尿病治療標的としてのKRAP遺伝子2010

    • Author(s)
      藤本崇宏、白澤専二
    • Organizer
      第2回福岡県医学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-01-31
    • Data Source
      KAKENHI-PROJECT-21790331
  • [Presentation] 新たな肥満・糖尿病治療標的としてのKRAP遺伝子2010

    • Author(s)
      藤本崇宏
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティ(埼玉市)
    • Year and Date
      2010-10-28
    • Data Source
      KAKENHI-PROJECT-21790331
  • [Presentation] 新たな肥満・糖尿病治療標的としてのKRAP遺伝子2010

    • Author(s)
      藤本崇宏、宮坂京子、白澤専二
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      埼玉
    • Year and Date
      2010-10-28
    • Data Source
      KAKENHI-PROJECT-21790331
  • [Presentation] Altered Energy Homeostasis and Resistance to Diet-Induced Obesity in KRAP-Deficient Mice2009

    • Author(s)
      藤本崇宏、宮坂京子、笹月健彦、加藤規弘、白澤専二
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-21790331
  • 1.  Itoh Kyoko (80243301)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  伏木 信次 (80150572)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  田中 秀和 (70273638)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  白澤 専二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  山形 要人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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