Hayashi Hisamitsu 林久允

… Alternative Names

HAYASHI Hisamitsu 林久允

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Researcher Number	10451858
Other IDs	https://orcid.org/0000-0002-5247-895X
Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 東京大学, 大学院薬学系研究科(薬学部), 准教授 2021: 東京大学, 大学院薬学系研究科(薬学部), 講師 2016 – 2020: 東京大学, 大学院薬学系研究科(薬学部), 助教 2011 – 2015: 東京大学, 薬学研究科(研究院), 助教 2007 – 2013: The University of Tokyo, Graduate School of Pharmaceutical Sciences, Professor
Review Section/Research Field	Principal Investigator Medical pharmacy / Medium-sized Section 47:Pharmaceutical sciences and related fields / Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Medical pharmacy / Biological Sciences
Keywords	Principal Investigator 胆汁酸 / ABCトランスポーター / 肝内胆汁うっ滞 / トランスポーター / 小児肝疾患 / 創薬 / 胆汁うっ滞 / タンパク質分解 / コレステロール / 細胞内ソーティング … More / 病態モデル / 医療創成 / 医療創生 / 健康長寿 / ドラッグリポジショニング / 大規模診療データベース / ハイスループットスクリーニング / iPS細胞由来肝細胞 / オミクスデータ解析 / 血球細胞 / 難病 / 遺伝性疾患 / 診断法 / 小児肝臓病 / 表現型解析 / マクロファージ / 診断 / 小児遺伝性肝疾患 / 輸送担体 / 胆汁うっ滞症 / ユビキチン / 肝細胞 / フェニルブチレート / フェニルブチレート … More Except Principal Investigator 薬物間相互作用 / トランスポーター / Mrps / 腎排泄 / CYP3A4 / 薬物トランスポーター / 血液脳関門 / 腎尿細管分泌 / 体内動態 / biliary excretion / drug-drue interaction / renal excretion / anti-HIV drugs / diuretics / transporters / metabolic enzymes / SULT / Mrp4 / Mrp3 / 小腸吸収 / 胆汁排泄 / HIV治療薬 / 利尿薬 / 代謝酵素 / 再吸収 / 内因性基質 / 中枢移行性 / SLCトランスポーター / 薬物動態 / MATE / OAT / 腎スライス / 薬剤感受性 / atorvastatin / 肝クリアランス / 律速段階 / OATP / MATEs / シメチジン / ヒト腎スライス / ヒト肝細胞 / フェノタイピング / クリアランスの律速段階 / プローブ薬 / 複合体 / 蛋白 / 薬剤反応性 / 薬学 / 排出輸送 / 血液精巣液関門 / ABCトランスポーター / 蛋白間相互作用 / トランスポートソーム Less

Study to simplify disease models for pediatric liver diseasesPrincipal Investigator
- Principal Investigator
  
  林久允
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
健康長寿社会の実現に資する革新的低コスト医療創製基盤の構築Principal Investigator
- Principal Investigator
  
  林久允
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  The University of Tokyo
Analysis of molecular mechanisms in the development of pediatric cholestatic liver diseasePrincipal Investigator
- Principal Investigator
  
  Hayashi Hisamitsu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Development of methods to realize medical theapy by enhancing the function of ABC transportersPrincipal Investigator
- Principal Investigator
  
  Hayashi Hisamitsu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokyo
Development of novel diagnostic method for refractory pediatric liver diseasesPrincipal Investigator
- Principal Investigator
  
  Hayashi Hisamitsu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Development of a strategy of drug development for ABC transporter-related diseasesPrincipal Investigator
- Principal Investigator
  
  Hayashi Hisamitsu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Development of novel therapeutic method for ABC transporter-related diseasesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Hisamitsu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Elucidation of the transporters, and integration research of their molecular entities and activities for the drug transport in the brain and kidneys
- Principal Investigator
  
  KUSUHARA Hiroyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Understanding of mechanism underlying intracellular sorting of hepatocanalicular transportersPrincipal Investigator
- Principal Investigator
  
  HAYASHI Hisamitsu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
New drug therapy of the transporter-related diseases through the modulation of membrane traffickingPrincipal Investigator
- Principal Investigator
  
  HAYASHI Hisamitsu
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
薬剤応答性における薬物トランスポートソームの動的制御機構の解明
- Principal Investigator
  
  楠原洋之
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Development of probe drugs for the evaluation of the functions of drug transporters in vivo in humans
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
トランスポートソームの機能制御による医薬品体内動態の制御
- Principal Investigator
  
  KUSUHARA Hiroyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Development of the quantitative prediction method of pharmacokinetics with considering the function of metabolic enzymes and transporters
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo

[Book] 医学のあゆみ-胆汁酸トランスポーターが関連する疾患と治療2012
- Author(s)
  林　久允
- Total Pages
  5
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-23790175
[Book] 分子標的トランスポーター (細胞工学5月号)」, 金井好克編2012
- Author(s)
  林久允
- Total Pages
  6
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-23790175
[Book] 細胞工学-胆汁酸トランスポーターのトラフィッキング制御による創薬2012
- Author(s)
  林　久允
- Total Pages
  5
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-23790175
[Book] 「トランスポートソーム生体膜輸送機構の全体像に迫る (遺伝子医学MOOK19)」金井好克編2011
- Author(s)
  林久允
- Total Pages
  6
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-23790175
[Book] トランスポートソーム生体膜輸送機構の全体像に迫る基礎,臨床,創薬応用研究の最新成果
- Author(s)
  林久允、杉山雄一
- Publisher
  株式会社メディカルドゥ
- Data Source
  KAKENHI-PROJECT-21790146
[Journal Article] Clinical symptoms, biochemistry, and liver histology during the native liver period of progressive familial intrahepatic cholestasis type 22024
- Author(s)
  Kondou Hiroki、Nakano Satoshi、Mizuno Tadahaya、Bessho Kazuhiko、Hasegawa Yasuhiro、Nakazawa Atsuko、Tanikawa Ken、Azuma Yoshihiro、Okamoto Tatsuya、Inui Ayano、Imagawa Kazuo、Kasahara Mureo、Zen Yoh、Suzuki Mitsuyoshi、Hayashi Hisamitsu
- Journal Title
  
  Orphanet Journal of Rare Diseases
  
  Volume: 19 Issue: 1 Pages: 57-57
- DOI
  10.1186/s13023-024-03080-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0172
[Journal Article] Rapid in vivo evaluation system for cholestasis-related genes in mice with humanized bile acid profiles2024
- Author(s)
  Kihiro Wakasa, Ryutaro Tamura, Shuhei Osaka, Hajime Takei, Akihiro Asai, Hiroshi Nittono, Hiroyuki Kusuhara, Hisamitsu Hayashi
- Journal Title
  
  Hepatology Communications
  
  Volume: e0382 Issue: 4
- DOI
  10.1097/hc9.0000000000000382
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KJ0803, KAKENHI-PROJECT-20KK0172
[Journal Article] Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis2023
- Author(s)
  Tamura Ryutaro、Sabu Yusuke、Mizuno Tadahaya、Mizuno Seiya、Nakano Satoshi、Suzuki Mitsuyoshi、Abukawa Daiki、Kaji Shunsaku、Azuma Yoshihiro、Inui Ayano、Okamoto Tatsuya、Shimizu Seiichi、Fukuda Akinari、Sakamoto Seisuke、Kasahara Mureo、Takahashi Satoru、Kusuhara Hiroyuki、Zen Yoh、Ando Tomohiro、Hayashi Hisamitsu
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 6763-6763
- DOI
  10.1038/s41467-023-42424-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16392, KAKENHI-PROJECT-23KJ0803, KAKENHI-PROJECT-20KK0172
[Journal Article] Healthy Patients With AKR1D1 Mutation Not Requiring Primary Bile Acid Therapy: A Case Series2023
- Author(s)
  Kimura Akihiko、Mori Jun、Pham Anh-Hoa Nguyen、Thi Kim-Oanh Bui、Takei Hajime、Murai Tsuyoshi、Hayashi Hisamitsu、Nittono Hiroshi
- Journal Title
  
  JPGN Reports
  
  Volume: 4 Issue: 4 Pages: e372-e372
- DOI
  10.1097/pg9.0000000000000372
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0172
[Journal Article] Clinicopathologic Features, Genetics, Treatment, and Long-Term Outcomes in Japanese Children and Young Adults with Benign Recurrent Intrahepatic Cholestasis: A Multicenter Study2023
- Author(s)
  Kato Ken、Umetsu Shuichiro、Togawa Takao、Ito Koichi、Kawabata Takayoshi、Arinaga-Hino Teruko、Tsumura Naoya、Yasuda Ryosuke、Mihara Yutaro、Kusano Hironori、Ito Shogo、Imagawa Kazuo、Hayashi Hisamitsu、Inui Ayano、Yamashita Yushiro、Mizuochi Tatsuki
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 12 Issue: 18 Pages: 5979-5979
- DOI
  10.3390/jcm12185979
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0172
[Journal Article] Dried blood spot-based newborn screening for bile acid synthesis disorders, Zellweger spectrum disorder, and Niemann-Pick type C1 by detection of bile acid metabolites2023
- Author(s)
  Muto Yamato、Suzuki Mitsuyoshi、Takei Hajime、Saito Nobutomo、Mori Jun、Sugimoto Satoru、Imagawa Kazuo、Nambu Ryusuke、Oguri Saori、Itonaga Tomoyo、Ihara Kenji、Hayashi Hisamitsu、Murayama Kei、Kakiyama Genta、Nittono Hiroshi、Shimizu Toshiaki
- Journal Title
  
  Molecular Genetics and Metabolism
  
  Volume: 140 Issue: 1-2 Pages: 107703-107703
- DOI
  10.1016/j.ymgme.2023.107703
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0172
[Journal Article] Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency2022
- Author(s)
  Li CZ, Ogawa H, Ng SS, Chen X, Kishimoto E, Sakabe K, Fukami A, Hu YC, Mayhew CN, Hellmann J, Miethke A, Tasnova NL, Blackford SJI, Tang ZM, Syanda AM, Ma L, Xiao F, Sambrotta M, Tavabie O, Soares F, Baker O, Danovi D, Hayashi H, Thompson RJ, Rashid ST, Asai A.
- Journal Title
  
  JHEP Reports
  
  Volume: 4 Issue: 4 Pages: 100446-100446
- DOI
  10.1016/j.jhepr.2022.100446
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0172
[Journal Article] Clinical and genetic features of congenital bile acid synthesis defect with a novel mutation in AKR1D1 gene sequencing2022
- Author(s)
  Pham AN, Thi KB, Thi MN, Ngo DN, Naritaka N, Nittono H, Hayashi H, Dao TT, Nguyen KT, Nguyen HN, Giang H, Tang HS, Nguyen TT, Truong DK, Tran MD.
- Journal Title
  
  Medicine
  
  Volume: 101 Issue: 25 Pages: e29476-e29476
- DOI
  10.1097/md.0000000000029476
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0172
[Journal Article] Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation2021
- Author(s)
  Hayashi H, Osaka S, Sakabe K, Fukami A, Kishimoto E, Aihara E, Sabu Y, Mizutani A, Kusuhara H, Naritaka N, Zhang W, Huppert SS, Sakabe M, Nakamura T, Hu YC, Mayhew C, Setchell K, Takebe T, Asai A.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 16 Issue: 2 Pages: 309-323
- DOI
  10.1016/j.stemcr.2020.12.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02800, KAKENHI-PROJECT-19K22416, KAKENHI-PROJECT-20KK0172
[Journal Article] A randomized trial to examine the impact of food on pharmacokinetics of 4-phenylbutyrate and change in amino acid availability after a single oral administration of sodium 4-phenylbutyrarte in healthy volunteers2021
- Author(s)
  Osaka Shuhei、Nakano Satoshi、Mizuno Tadahaya、Hiraoka Yuka、Minowa Kei、Hirai Saeko、Mizutani Ayumu、Sabu Yusuke、Miura Yoshiki、Shimizu Toshiaki、Kusuhara Hiroyuki、Suzuki Mitsuyoshi、Hayashi Hisamitsu
- Journal Title
  
  Molecular Genetics and Metabolism
  
  Volume: 132 Issue: 4 Pages: 220-226
- DOI
  10.1016/j.ymgme.2021.02.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0172
[Journal Article] Influence of food on pharmacokinetics and pharmacodynamics of 4-phenylbutyrate in patients with urea cycle disorders2021
- Author(s)
  Nakajima Yoko、Osaka Shuhei、Mizuno Tadahaya、Yokoi Katsuyuki、Nakano Satoshi、Hirai Saeko、Hiraoka Yuka、Miura Yoshiki、Suzuki Mitsuyoshi、Kusuhara Hiroyuki、Hayashi Hisamitsu
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 29 Pages: 100799-100799
- DOI
  10.1016/j.ymgmr.2021.100799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0172
[Journal Article] Proposal of a liver histology‐based scoring system for bile salt export pump deficiency2020
- Author(s)
  Zen Yoh、Kondou Hiroki、Nakazawa Atsuko、Tanikawa Ken、Hasegawa Yasuhiro、Bessho Kazuhiko、Imagawa Kazuo、Ishige Takashi、Inui Ayano、Suzuki Mitsuyoshi、Kasahara Mureo、Yamamoto Kouji、Yoshioka Takako、Kage Masayoshi、Hayashi Hisamitsu
- Journal Title
  
  Hepatology Research
  
  Volume: Online ahead of print. Issue: 6 Pages: 754-762
- DOI
  10.1111/hepr.13494
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16240, KAKENHI-PROJECT-17H04007, KAKENHI-PROJECT-18K19391
[Journal Article] Long-Term Outcomes of Living-Donor Liver Transplantation for Progressive Familial Intrahepatic Cholestasis Type 12020
- Author(s)
  Okamoto Tatsuya、Sonoda Mari、Ogawa Eri、Ito Shogo、Togawa Takao、Hayashi Hisamitsu、Okajima Hideaki、Uemoto Shiji
- Journal Title
  
  Journal of Pediatric Gastroenterology & Nutrition
  
  Volume: Publish Ahead of Print Issue: 3 Pages: 425-429
- DOI
  10.1097/mpg.0000000000002983
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08567, KAKENHI-PROJECT-18K19391
[Journal Article] Effect of food on the pharmacokinetics and therapeutic efficacy of 4-phenylbutyrate in progressive familial intrahepatic cholestasis2019
- Author(s)
  Nakano S, Osaka S, Sabu Y, Minowa K, Hirai S, Kondou H, Kimura T, Azuma Y, Watanabe S, Inui A, Bessho K, Nakamura H, Kusano H, Nakazawa A, Tanikawa K, Kage M, Shimizu T, Kusuhara H, Zen Y, Suzuki M, Hayashi H.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1
- DOI
  10.1038/s41598-019-53628-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19391, KAKENHI-PROJECT-17H04007
[Journal Article] Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis.2018
- Author(s)
  Imagawa K, Hayashi H, Sabu Y, Tanikawa K, Fujishiro J, Kajikawa D, Wada H, Kudo T, Kage M, Kusuhara H, Sumazaki R.
- Journal Title
  
  J Hum Genet.
  
  Volume: 印刷中 Issue: 5 Pages: 569-577
- DOI
  10.1038/s10038-018-0431-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04007, KAKENHI-PROJECT-17K16240
[Journal Article] Assessment of ATP8B1 Deficiency in Pediatric Patients With Cholestasis Using Peripheral Blood Monocyte-Derived Macrophages.2018
- Author(s)
  Hayashi H, Naoi S, Togawa T, Hirose Y, Kondou H, Hasegawa Y, Abukawa D, Sasaki M, Muroya K, Watanabe S, Nakano S, Minowa K, Inui A, Fukuda A, Kasahara M, Nagasaka H, Bessho K, Suzuki M, Kusuhara H.
- Journal Title
  
  EBioMedicine.
  
  Volume: 27 Pages: 187-199
- DOI
  10.1016/j.ebiom.2017.10.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04007
[Journal Article] Effects of 4-phenylbutyrate therapy in a preterm infant with cholestasis and liver fibrosis2016
- Author(s)
  Ito S, Hayashi H, Sugiura T, Ito K, Ueda H, Togawa T, Endo T, Tanikawa K, Kage M, Kusuhara H, Saitoh S.
- Journal Title
  
  Pediatr Int.
  
  Volume: Feb 4 Issue: 6 Pages: 506-509
- DOI
  10.1111/ped.12839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461625, KAKENHI-PROJECT-26460192, KAKENHI-PROJECT-26870489, KAKENHI-PROJECT-16K10070
[Journal Article] Pim-1L Protects Cell Surface-Resident ABCA1 From Lysosomal Degradation in Hepatocytes and Thereby Regulates Plasma High-Density Lipoprotein Level.2016
- Author(s)
  Katsube A, Hayashi H, Kusuhara H.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 36(12) Issue: 12 Pages: 2304-2314
- DOI
  10.1161/atvbaha.116.308472
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J09012, KAKENHI-PROJECT-26460192
[Journal Article] Successful treatment with 4-phenylbutyrate in a patient with benign recurrent intrahepatic cholestasis type 2 refractory to biliary drainage and bilirubin absorption.2016
- Author(s)
  Hayashi H, Naoi S, Hirose Y, Matsuzaka Y, Tanikawa K, Igarashi K, Nagasaka H, Kage M, Inui A, Kusuhara H.
- Journal Title
  
  Hepatol Res.
  
  Volume: 46(2) Issue: 2 Pages: 192-200
- DOI
  10.1111/hepr.12561
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460192
[Journal Article] Impaired Hepatic Uptake by Organic Anion-Transporting Polypeptides Is Associated with Hyperbilirubinemia and Hypercholanemia in Atp11c Mutant Mice.2015
- Author(s)
  Matsuzaka Y, Hayashi H, Kusuhara H.
- Journal Title
  
  Mol Pharmacol.
  
  Volume: 88(6) Issue: 6 Pages: 1085-92
- DOI
  10.1124/mol.115.100578
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460192
[Journal Article] Cellular Cholesterol Accumulation Facilitates Ubiquitination and Lysosomal Degradation of Cell Surface-Resident ABCA1.2015
- Author(s)
  Mizuno T, Hayashi H, Kusuhara H.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 35(6) Issue: 6 Pages: 1347-56
- DOI
  10.1161/atvbaha.114.305182
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460192
[Journal Article] Development of New Therapeutic Strategy for Transporter-related Diseases2014
- Author(s)
  Hayashi H
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 134 Issue: 10 Pages: 1007-1011
- DOI
  10.1248/yakushi.14-00186
- NAID
  130004693883
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2014-10-01
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-26460192
[Journal Article] Intractable itch relieved by 4-phenylbutyrate therapy in patients with progressive familial intrahepatic cholestasis type 1.2014
- Author(s)
  Hasegawa Y, Hayashi H, Naoi S, Kondou H, Bessho K, Igarashi K, Hanada K, Nakao K, Kimura T, Konishi A, Nagasaka H, Miyoshi Y, Ozono K, Kusuhara H
- Journal Title
  
  Orphanet J Rare Dis.
  
  Volume: 9 Issue: 1 Pages: 89-89
- DOI
  10.1186/1750-1172-9-89
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J10600, KAKENHI-PROJECT-26460192
[Journal Article] AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.2012
- Author(s)
  Hayashi H
- Journal Title
  
  Hepatology
  
  Volume: 55 Issue: 6 Pages: 1889-900
- DOI
  10.1002/hep.25591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790175
[Journal Article] AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.2012
- Author(s)
  Hayashi H, Inamura K, Aida K, Naoi S, Horikawa R, Nagasaka H, Takatani T, Fukushima T, Hattori A, Yabuki T, Horii I, Sugiyama Y.
- Journal Title
  
  Hepatology.
  
  Volume: 55(6) Pages: 1889-900
- Data Source
  KAKENHI-PROJECT-23790175
[Journal Article] Sorting nexin 27 interacts with multidrug resistance-associated protein 4(MRP4) and mediates internalization of MRP42012
- Author(s)
  Hayashi H, Naoi S, Nakagawa T, Nishikawa T, Fukuda H, Imajoh-OhmiS, Kondo A, Kubo K, Yabuki T, HattoriA, Hirouchi M, Sugiyama Y
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 287 Issue: 18 Pages: 15054-65
- DOI
  10.1074/jbc.m111.337931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J10600, KAKENHI-PROJECT-23790175, KAKENHI-PROJECT-24390280
[Journal Article] Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2.2012
- Author(s)
  Misawa T, Hayashi H, Sugiyama Y, Hashimoto Y.
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 20(9) Pages: 2940-9
- Data Source
  KAKENHI-PROJECT-23790175
[Journal Article] E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity.2012
- Author(s)
  Misawa T, Hayashi H, Makishima M, Sugiyama Y, Hashimoto Y.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 22(12) Pages: 3962-6
- Data Source
  KAKENHI-PROJECT-23790175
[Journal Article] 4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration.2012
- Author(s)
  Hayashi H, Mizuno T, Horikawa R, Nagasaka H, Yabuki T, Takikawa H, Sugiyama Y.
- Journal Title
  
  J Hepatol.
  
  Volume: 56(5) Pages: 1136-44
- Data Source
  KAKENHI-PROJECT-23790175
[Journal Article] Ubiquitination is associated with lysosomal degradation of cell surface-resident ABCA1 through the ESCRT pathway.2011
- Author(s)
  Mizuno T, Hayashi H, Naoi S, Sugiyama Y
- Journal Title
  
  Hepatology.
  
  Volume: 54(2) Pages: 631-43
- Data Source
  KAKENHI-PROJECT-23790175
[Journal Article] Calpain-mediated cleavage negatively regulates the expression level of ABCG12011
- Author(s)
  Hori N, Hayashi H, Sugiyama Y : equally contributed
- Journal Title
  
  Atherosclerosis.
  
  Volume: 215 Pages: 383-91
- NAID
  130004640071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790146
[Journal Article] Ubiquitination is associated with lysosomal degradation of cell surface-resident ATP-binding cassette transporter A1 (ABCA1) through the endosomal sorting complex required for transport (ESCRT) pathway2011
- Author(s)
  Tadahaya Mizuno, Hisamitsu Hayashi, Sotaro Naoi, Yuichi Sugiyama
- Journal Title
  
  Hepatology
  
  Volume: 54 Issue: 2 Pages: 631-643
- DOI
  10.1002/hep.24387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J11195, KAKENHI-PROJECT-23790175
[Journal Article] Ubiquitination is associated with lysosomal degradation of cell surface-resident ABCA1 through the ESCRT pathway2011
- Author(s)
  Mizuno T, Hayashi H, Naoi S, Sugiyama Y : equally contributed
- Journal Title
  
  Hepatology
  
  Volume: (In press)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790146
[Journal Article] Calpain-mediated cleavage negatively regulates the expression level of ABCG1.2011
- Author(s)
  Hori N, Hayashi H, Sugiyama Y.
- Journal Title
  
  Atherosclerosis. 215(2)
  
  Pages: 383-391
- NAID
  130004640071
- Data Source
  KAKENHI-PROJECT-21790146
[Journal Article] Sugiyama Y.Calpain-mediated cleavage negatively regulates the expression level of ABCG1.2011
- Author(s)
  Hori N, Hayashi H
- Journal Title
  
  Atherosclerosis.
  
  Volume: 215(2) Pages: 383-91
- Data Source
  KAKENHI-PROJECT-23790175
[Journal Article] Calpain-mediated cleavage negatively regulates the expression level of ABCG1.2011
- Author(s)
  Hori N, Hayashi H, Sugiyama Y.
- Journal Title
  
  Atherosclerosis.
  
  Volume: 215 Issue: 2 Pages: 383-91
- DOI
  10.1016/j.atherosclerosis.2010.12.033
- NAID
  130004640071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790175
[Journal Article] Favorable effect of 4-phenylacetate on liver functions attributable to enhanced bile salt export pump expression in ornithine transcarbamylase-deficient children.2010
- Author(s)
  Nagasaka H, Yorifuji T, Kobayashi K, Takikawa H, Komatsu H, Inui A, Fujisawa T, Miida T, Tsukahara H, Takatani T, Hayashi H.
- Journal Title
  
  Mol Genet Metab. 100(2)
  
  Pages: 123-128
- Data Source
  KAKENHI-PROJECT-21790146
[Journal Article] Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump(BSEP/ABCB11)2010
- Author(s)
  Kato T, Hayashi H, Sugiyama Y : equally contributed
- Journal Title
  
  BBA_molecular and cell biology of lipids (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790146
[Journal Article] Direct and rapid genotyping of glutathione-S-transferase M1 and T1 from human blood specimens using the SmartAmp2 method2010
- Author(s)
  Okada R、Ishizu Y、Endo R、Lezhava A、Ieiri I、Kusuhara H、Sugiyama Y、Hayashizaki Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 38巻 Issue: 2 Pages: 1636-1639
- DOI
  10.1124/jpet.110.170092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Direct and rapid genotyping of glutathione-S-transferase M1 and T1 from human blood specimens using the SmartAmp2 method.2010
- Author(s)
  Okada R, Ishizu Y, Endo R, Lezhava A, Ieiri I, Kusuhara H, Sugiyama Y, Hayashizaki Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 38 Pages: 1636-1639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11).2010
- Author(s)
  Kato T, Hayashi H, Sugiyama Y.
- Journal Title
  
  Biochim Biophys Acta. 1801(9)
  
  Pages: 1005-1012
- Data Source
  KAKENHI-PROJECT-21790146
[Journal Article] Sodium 4-phenylbutyrate induces functional cell surface expression of wild-type and PFIC2-type mutated BSEP2007
- Author(s)
  Hayashi H, Sugiyama Y
- Journal Title
  
  Hepatology (in press)
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] 4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps2007
- Author(s)
  Hayashi H, et. al.
- Journal Title
  
  Hepatology 45
  
  Pages: 1506-1516
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Ubiquitination is associated with lysosomal degradation of cell surface-resident ABCA1 through the ESCRT pathway.
- Author(s)
  Mizuno T, Hayashi H, Naoi S, Sugiyama Y.
- Journal Title
  
  Hepatology. in press
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 進行性家族性肝内胆汁うっ滞症（PFIC）における肝逸脱酵素値による病型鑑別2023
- Author(s)
  中野聡, 入戸野博, 鈴木光幸, 乾あやの，林久允
- Organizer
  第38回　神奈川県小児肝・消化器疾患研究会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 小児期発症胆汁うっ滞疾患レジストリCIRCLe報告1：現在までの進捗状況2023
- Author(s)
  中野聡, 今川和生, 伊藤彰悟, 戸川貴夫, 三原勇太郎, 草野弘宣, 入戸野博, 林久允
- Organizer
  第50回日本小児栄養消化器肝臓学会学術集会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 進行性家族性肝内胆汁うっ滞症２型の自己肝自然歴についての疫学研究2023
- Author(s)
  近藤宏樹、中野聡、水野忠快、別所一彦、長谷川泰浩、中澤温子、谷川健、東良紘、岡本竜弥、乾あやの、今川和生、笠原群生、全陽、鈴木光幸、林久允
- Organizer
  第39回日本小児肝臓研究会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 小児期発症の胆汁うっ滞性肝疾患を対象としたレジストリ（CIRCLe）～構築の経緯、運用の現況、今後の活用を見据えた取り組みについて～2023
- Author(s)
  林久允
- Organizer
  第50回日本小児栄養消化器肝臓学会学術集会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 小児胆汁うっ滞性肝疾患の病態分子基盤の理解に基づく治療法の創出2023
- Author(s)
  林久允
- Organizer
  第39回日本小児肝臓研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 小児期発症胆汁うっ滞疾患レジストリCIRCLe報告3：全エクソーム解析が診断の一助となったミオチュブラーミオパチー肝紫斑病の1例2023
- Author(s)
  伊藤彰悟、伊藤孝一、谷村知繁、戸川貴夫、今川和生、林久允
- Organizer
  第50回日本小児栄養消化器肝臓学会学術集会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] MYO5Bに複合ヘテロ変異を認めたγGTP正常胆汁うっ滞の１例2023
- Author(s)
  伊藤彰悟、伊藤孝一、谷村知繁、戸川貴夫、今川和生、林久允
- Organizer
  第39回日本小児肝臓研究会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 胆汁うっ滞性肝疾患の病態解明・診断支援に資する肝特異的遺伝子編集マウスの迅速作出法の確立2023
- Author(s)
  若狭希洋、田村隆太郎、大坂周平、林久允
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 成人期に遺伝子診断された進行性家族性肝内胆汁うっ滞症１型の１例2023
- Author(s)
  齋藤博大、今川和生、須磨崎亮、伊藤彰悟、戸川貴夫、林久允
- Organizer
  第39回日本小児肝臓研究会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 小児期発症胆汁うっ滞疾患レジストリCIRCLe報告2：遺伝子パネルの改良と未診断症例に対する全エクソーム解析2023
- Author(s)
  今川和生、鈴木寿人、伊藤彰悟、戸川貴夫、中野聡、小崎健次郎、林久允
- Organizer
  第50回日本小児栄養消化器肝臓学会学術集会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 小児遺伝性肝疾患の病態機序解明と治療法創出2023
- Author(s)
  林久允
- Organizer
  第59回日本肝臓学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 未診断の小児期発症胆汁うっ滞性疾患における全エクソーム解析及びRNAseqの有用性2023
- Author(s)
  今川和生、伊藤彰悟、戸川貴夫、鈴木寿人、東良紘、谷川健、林久允
- Organizer
  第39回日本小児肝臓研究会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 生体肝移植後に脂肪肝を来たしたPFIC5の1例2023
- Author(s)
  齊藤寛貴、中野聡、武藤大和、平井沙依子、箕輪圭、谷川健、阪本靖介、福田晃也、笠原群生、林久允、鈴木光幸、清水俊明
- Organizer
  第39回日本小児肝臓研究会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 肝胆道系輸送の分子基盤解明を加速化する肝特異的遺伝子編集マウスの迅速作出法の確立2022
- Author(s)
  若狭希洋、田村隆太郎、林久允
- Organizer
  第49回日本小児栄養消化器肝臓学会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 小児胆汁うっ滞性肝疾患を対象とした創薬研究2022
- Author(s)
  林久允
- Organizer
  京都小児外科研究会セミナー2022年冬
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 肝胆道系輸送の分子基盤解明を加速化する肝特異的遺伝子編集マウスの迅速作出法の確立2022
- Author(s)
  若狭希洋、田村隆太郎、大坂周平、林久允
- Organizer
  第43回胆汁酸研究会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 本邦における良性反復性肝内胆汁うっ滞症の臨床像：多施設共同研究2022
- Author(s)
  加藤健，梅津守一郎, 乾あやの, 伊藤孝一, 河畑孝佳, 坂本理恵子, 別所一彦, 安田亮輔, 今川和生, 戸川貴夫, 林久允, 水落建輝
- Organizer
  第49回日本小児栄養消化器肝臓学会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 小児期発症の胆汁うっ滞性肝疾患を対象とした多施設前向きレジストリ研究(CIRCLe)2022
- Author(s)
  小西健一郎、中野聡、戸川貴夫、今川和生、伊藤彰悟、三原勇太郎、草野弘宣、鹿毛政義、入戸野博、林久允
- Organizer
  第49回日本胆道閉鎖症研究会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] Drug development of cholestatic liver diseases in children2022
- Author(s)
  Hisamitsu Hayashi
- Organizer
  The Korean Society of Applied Pharmacology（KSAP）2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03400
[Presentation] 小児胆汁うっ滞性肝疾患の病態分子基盤の理解に向けて2022
- Author(s)
  林　久允
- Organizer
  第54回武蔵野小児肝臓病懇話会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03400
[Presentation] Drug development of cholestatic liver diseases in children2022
- Author(s)
  Hisamitsu Hayashi
- Organizer
  The Korean Society of Applied Pharmacology（KSAP）2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 小児胆汁うっ滞性肝疾患の病態分子基盤の理解に向けて2022
- Author(s)
  林久允
- Organizer
  第54回武蔵野小児肝臓病懇話会
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 小児胆汁うっ滞性肝疾患を対象とした創薬研究2022
- Author(s)
  林　久允
- Organizer
  京都小児外科研究会セミナー2022年冬
- Invited
- Data Source
  KAKENHI-PROJECT-20H03400
[Presentation] リファンピシン投与におけるグルクロン酸抱合型胆汁酸の体内動態2021
- Author(s)
  鈴木光幸、武井一、林久允、田村隆太郎、武藤大和、平井沙依子、今川和生、戸川貴夫、村井毅、木村昭彦、入戸野博、清水俊明
- Organizer
  第48回日本小児栄養消化器肝臓学会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] Atp11c欠損により生じるTG代謝異常の機序解析2021
- Author(s)
  水谷歩、佐分雄祐、楠原洋之、林久允
- Organizer
  第48回日本小児栄養消化器肝臓学会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 胆汁酸3位グルクロン酸抱合体の肝取り込みにはOATP1B1, OATP1B3が寄与する2021
- Author(s)
  田村　隆太郎、武井一、鈴木　光幸、成高　中之、佐々木　隆浩、村井　毅、木村　昭彦、清水　俊明、楠原　洋之、入戸野　博、林　久允
- Organizer
  第42回胆汁酸研究会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] OATP1B1、OATP1B3は胆汁酸3位グルクロン酸抱合体の肝取り込みに働く2021
- Author(s)
  田村　隆太郎、武井一、鈴木　光幸、成高　中之、佐々木　隆浩、村井　毅、木村　昭彦、清水　俊明、楠原　洋之、入戸野　博、林　久允
- Organizer
  第48回日本小児栄養消化器肝臓学会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 小児遺伝性肝疾患の病態解明と治療戦略の創出2021
- Author(s)
  林久允
- Organizer
  第48回日本小児栄養消化器肝臓学会
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] ユビキチンリガーゼAIP4を介した細胞膜上ABCA1の発現調節機構の解析2021
- Author(s)
  守屋一輝、水野忠快、勝部彬、楠原洋之、林久允
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-20H03400
[Presentation] Atp11c 欠損は肝臓を起因とする TG 代謝異常を呈する2021
- Author(s)
  水谷歩、佐分雄祐、楠原洋之、林久允
- Organizer
  第37回日本小児肝臓研究会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] PFIC type2に対するフェニル酪酸Na初回導入時の治療戦略2021
- Author(s)
  武藤大和、鈴木光幸、中野聡、今川和生、田川学、戸川貴夫、三原勇太郎、草野弘宣、林久允、清水俊明
- Organizer
  第37回日本小児肝臓研究会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 小児期発症の胆汁うっ滞性肝疾患を対象とした多施設前向きレジストリ研究（CIRCLe）の立案の経緯、進捗状況、今後の展望2021
- Author(s)
  林久允
- Organizer
  第48回日本小児栄養消化器肝臓学会
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 胆汁うっ滞を伴う早産児・低出生体重児における遺伝学的解析2021
- Author(s)
  今川和生、戸川貴夫、伊藤彰悟、伊藤孝一、林久允、高田英俊、斎藤伸治
- Organizer
  第124回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 進行性家族性肝内胆汁うっ滞症2型に合併する掻痒症に対する薬物療法2021
- Author(s)
  武藤大和，鈴木光幸，中野聡，箕輪圭，今川和生，戸川貴夫，三原勇太郎，草野弘宣，林久允，清水俊明
- Organizer
  第48回日本小児栄養消化器肝臓学会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 乳児胆汁うっ滞症に対するリファンピシン治療中のグルクロン酸抱合型胆汁酸の体内動態2021
- Author(s)
  鈴木光幸、武井一、中野聡、田村隆太郎、林久允、村井毅、木村昭彦、入戸野博、清水俊明
- Organizer
  第42回胆汁酸研究会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] ユビキチンリガーゼAIP4を介した細胞膜上ABCA1の発現調節機構の解析2021
- Author(s)
  守屋一輝、水野忠快、勝部彬、楠原洋之、林久允
- Organizer
  第20回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20H03400
[Presentation] 東南アジア地域における原因不明胆汁うっ滞小児に対する次世代シークエンサー解析2021
- Author(s)
  今川和生、伊藤彰悟、戸川貴夫、伊藤孝一、林久允
- Organizer
  第48回日本小児栄養消化器肝臓学会
- Data Source
  KAKENHI-PROJECT-20KK0172
[Presentation] 進行性家族性肝内胆汁うっ滞症2型の病態解明を基盤とした創薬研究2019
- Author(s)
  林　久允
- Organizer
  京都小児外科セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] 進行性家族性肝内胆汁うっ滞症患者が保因する変異が病因遺伝子のsplicingに及ぼす影響の検討2019
- Author(s)
  水谷　歩, 佐分　雄祐, 伊藤　彰吾, 伊藤　孝一, 楠原　洋之, 戸川　貴夫, 林　久允
- Organizer
  第３６回日本小児肝臓研究会
- Data Source
  KAKENHI-PROJECT-17H04007
[Presentation] Repurposing of 4-phenylbutyrate for treatment of pediatric liver diseases with intrahepatic cholestasis2019
- Author(s)
  Hisamitsu Hayashi
- Organizer
  JDDW2019
- Invited
- Data Source
  KAKENHI-PROJECT-17H04007
[Presentation] 肝内胆汁うっ滞症に対する創薬研究を基盤としたリバーストランスレーショナルリサーチ2019
- Author(s)
  林　久允
- Organizer
  第２回若手研究者コミュニティー: 順天堂大学
- Invited
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] トランスポーター関連希少疾患に対する新規治療戦略の開発を指向した創薬研究2019
- Author(s)
  林　久允
- Organizer
  第26回HAB研究機構学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] Translational and reverse translational research on pediatric cholestatic liver diseases2019
- Author(s)
  Hisamitsu Hayashi
- Organizer
  THE 14th SUGIYAMA LABORATORY (RIKEN) OPEN SYMPOSIUM
- Invited
- Data Source
  KAKENHI-PROJECT-17H04007
[Presentation] Development of Novel Medical Therapy for Pediatric Liver Diseases with Intrahepatic Cholestasis2019
- Author(s)
  Hisamitsu Hayashi
- Organizer
  APASL STC Tokyo 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04007
[Presentation] Translational and reverse translational research on pediatric cholestatic liver diseases2019
- Author(s)
  Hisamitsu Hayashi
- Organizer
  THE 14th SUGIYAMA LABORATORY (RIKEN) OPEN SYMPOSIUM
- Invited
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] 進行性家族性肝内胆汁うっ滞症2型の病態解明を基盤とした創薬研究2019
- Author(s)
  林　久允
- Organizer
  京都小児外科セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17H04007
[Presentation] 家族性肝内胆汁うっ滞症の成因、診断、治療に関する最新知見2019
- Author(s)
  林　久允
- Organizer
  第46回日本小児栄養消化器肝臓学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] 肝内胆汁うっ滞症に対する創薬研究を基盤としたリバーストランスレーショナルリサーチ2019
- Author(s)
  林　久允
- Organizer
  第２回若手研究者コミュニティー: 順天堂大学
- Invited
- Data Source
  KAKENHI-PROJECT-17H04007
[Presentation] 日本における希少難病を対象とした治験について～PFIC2の事例を通して感じたこと～2019
- Author(s)
  林久允
- Organizer
  RDD東大薬学部
- Invited
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] 家族性肝内胆汁うっ滞症の成因、診断、治療に関する最新知見2019
- Author(s)
  林　久允
- Organizer
  第46回日本小児栄養消化器肝臓学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04007
[Presentation] 進行性家族性肝内胆汁うっ滞症患者が保因する変異が病因遺伝子のsplicingに及ぼす影響の検討2019
- Author(s)
  水谷　歩, 佐分　雄祐, 伊藤　彰吾, 伊藤　孝一, 楠原　洋之, 戸川　貴夫, 林　久允
- Organizer
  第３６回日本小児肝臓研究会
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] 家族性肝内胆汁うっ滞症2型の病型鑑別を目的としたABCB11の病因変異の解析2019
- Author(s)
  佐分　雄祐, 水谷　歩, 伊藤　彰吾, 伊藤　孝一, 楠原　洋之, 戸川　貴夫, 林　久允
- Organizer
  第３６回日本小児肝臓研究会
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] 家族性肝内胆汁うっ滞症患者が保因する変異が病因遺伝子のsplicingに及ぼす影響の検討2019
- Author(s)
  水谷　歩, 佐分　雄祐, 伊藤　彰吾, 伊藤　孝一, 楠原　洋之, 戸川　貴夫, 林　久允
- Organizer
  第46回日本小児栄養消化器肝臓学会
- Data Source
  KAKENHI-PROJECT-17H04007
[Presentation] トランスポーター関連希少疾患に対する新規治療戦略の開発を指向した創薬研究2019
- Author(s)
  林　久允
- Organizer
  第26回HAB研究機構学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04007
[Presentation] 難治性肝内胆汁うっ滞症の医薬品開発研究を基盤としたリバーストランスレーショナルリサーチ2019
- Author(s)
  林　久允
- Organizer
  第11回小児肝臓・肝移植研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] Development of Novel Medical Therapy for Pediatric Liver Diseases with Intrahepatic Cholestasis2019
- Author(s)
  Hisamitsu Hayashi
- Organizer
  APASL STC Tokyo 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] 家族性肝内胆汁うっ滞症患者が保因する変異が病因遺伝子のsplicingに及ぼす影響の検討2019
- Author(s)
  水谷　歩, 佐分　雄祐, 伊藤　彰吾, 伊藤　孝一, 楠原　洋之, 戸川　貴夫, 林　久允
- Organizer
  第46回日本小児栄養消化器肝臓学会
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] 難治性肝内胆汁うっ滞症の医薬品開発研究を基盤としたリバーストランスレーショナルリサーチ2019
- Author(s)
  林　久允
- Organizer
  第11回小児肝臓・肝移植研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04007
[Presentation] ユビキチンリガーゼAIP4を介した細胞膜上ABCA1の発現調節機構の解析2019
- Author(s)
  守屋一輝、水野忠快、勝部彬、楠原洋之、林久允
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17H04007
[Presentation] Repurposing of 4-phenylbutyrate for treatment of pediatric liver diseases with intrahepatic cholestasis2019
- Author(s)
  Hisamitsu Hayashi
- Organizer
  JDDW2019
- Invited
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] 家族性肝内胆汁うっ滞症2型の病型鑑別を目的としたABCB11の病因変異の解析2019
- Author(s)
  佐分　雄祐, 水谷　歩, 伊藤　彰吾, 伊藤　孝一, 楠原　洋之, 戸川　貴夫, 林　久允
- Organizer
  第３６回日本小児肝臓研究会
- Data Source
  KAKENHI-PROJECT-17H04007
[Presentation] 胆道閉鎖症が否定された胆汁うっ滞症例の早期診断・症例登録システムの構築に向けた試み2018
- Author(s)
  林久允、近藤宏樹、別所一彦、戸川貴夫
- Organizer
  第45回　日本胆道閉鎖症研究会
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] 進行性家族性肝内胆汁うっ滞症に対するブフェニールの医薬品開発研究について（進捗状況報告）2018
- Author(s)
  林久允、近藤宏樹、別所一彦、箕輪圭、戸川貴夫、水落建輝、村上潤、虻川大樹、乾あやの
- Organizer
  第45回　日本小児栄養消化器肝臓学会
- Data Source
  KAKENHI-PROJECT-18K19391
[Presentation] 進行性家族性肝内胆汁うっ滞症の克服に向けた病態解明と診断・治療法の開発2016
- Author(s)
  林久允
- Organizer
  第38回胆汁酸研究会
- Place of Presentation
  久留米シティプラザ（福岡・久留米）
- Invited
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] Development of pharmacotherapy for progressive familial intrahepatic cholestasis (PFIC)2016
- Author(s)
  Hisamitsu Hayashi
- Organizer
  ABC 2016
- Place of Presentation
  インスブルック、オーストリア
- Year and Date
  2016-03-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] ドラッグリポジショニングによる小児難治性肝疾患の医薬品開発2016
- Author(s)
  林久允
- Organizer
  第37回日本臨床薬理学会学術総会
- Place of Presentation
  米子コンベンションセンター（鳥取・米子）
- Invited
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] 進行性家族性肝内胆汁うっ滞症(PFIC)の診断法、治療法について2016
- Author(s)
  林久允
- Organizer
  第151回お茶の水木曜会
- Place of Presentation
  順天堂大学（東京・文京区）
- Invited
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] 進行性家族性肝内胆汁うっ滞症の克服に向けた診断法・治療法の開発2016
- Author(s)
  林久允
- Organizer
  第43回日本小児栄養消化器肝臓学会
- Place of Presentation
  つくば国際会議場（茨城・筑波）
- Invited
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] 小児難治性希少肝疾患(進行性家族性肝内胆汁うっ滞症)の診断法、治療法の開発2016
- Author(s)
  林久允
- Organizer
  第11回トランスポーター研究会
- Place of Presentation
  京都大学　宇治キャンパスきはだホール（京都・宇治市）
- Invited
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] 進行性家族性肝内胆汁うっ滞症に対するフェニル酪酸の治療効果の検証2015
- Author(s)
  林　久允
- Organizer
  第118回日本小児科学会学術集会
- Place of Presentation
  大阪国際会議場 / リーガロイヤルホテル大阪（大阪府・大阪市）
- Year and Date
  2015-04-19
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] 進行性家族性肝内胆汁うっ滞症に対する特効薬開発を指向したドラッグリポジショニング研究2015
- Author(s)
  林　久允
- Organizer
  JDDW2015
- Place of Presentation
  グランドプリンスホテル新高輪（東京都・港区）
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] 胆汁酸トランスポーターBile salt export pumpを標的とした創薬研究2015
- Author(s)
  林　久允
- Organizer
  第31回日本DDS学会
- Place of Presentation
  京王プラザホテル（東京都・新宿区）
- Year and Date
  2015-07-02
- Invited
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] 進行性家族性肝内胆汁うっ滞症の特効薬の開発2015
- Author(s)
  林　久允
- Organizer
  日本薬物動態学会　第29回ワークショップ
- Place of Presentation
  学術総合センター（東京都・千代田区）
- Year and Date
  2015-05-15
- Invited
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] 進行性家族性肝内胆汁うっ滞症治療を指向したドラッグリポジショニング研究2014
- Author(s)
  林　久允
- Organizer
  第３６回胆汁酸研究会
- Place of Presentation
  東京
- Year and Date
  2014-11-22
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] 4-phenylbutyrateのPFIC2症例に対する治療効果の検討2014
- Author(s)
  林　久允
- Organizer
  第２１回肝細胞研究会
- Place of Presentation
  東京
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] 進行性家族性肝内胆汁うっ滞症に対する医薬品開発2014
- Author(s)
  林　久允
- Organizer
  第３６回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2014-11-20
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] Beneficial effects of 4-phenylbutylate therapy in patients with familial intrahepatic cholestasis2014
- Author(s)
  Hisamitsu Hayashi
- Organizer
  AASLD2014
- Place of Presentation
  Boston, MA, US
- Year and Date
  2014-11-10
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] ドラッグリポジショニングによる進行性家族性肝内胆汁うっ滞症治療薬の開発2014
- Author(s)
  林　久允
- Organizer
  第３１回日本小児肝臓学会
- Place of Presentation
  久留米
- Year and Date
  2014-07-17
- Data Source
  KAKENHI-PROJECT-26460192
[Presentation] PFIC2の原因となる変異型BSEPの機能を修正する新規小分子の発見と構造展開2012
- Author(s)
  三澤隆史、林久允、杉山雄一、橋本祐一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23790175
[Presentation] NEW DRUG DEVELOPMENT FOR LIVER DISORDERS WITH INTRAHEPATIC CHOLESTASIS2012
- Author(s)
  林　久允
- Organizer
  第27回日本薬物動態学会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23790175
[Presentation] Functional Characterization of organic cation transport in HEK293 cells2012
- Author(s)
  小林和正, 他
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] 胆汁酸トランスポーターBSEPの内在化に関わるモチーフの探索2012
- Author(s)
  林　久允
- Organizer
  第27年回日本薬剤学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790175
[Presentation] Functional characterization of organic cation transport in HEK293 cells2012
- Author(s)
  小林和正
- Organizer
  GPEN2012
- Place of Presentation
  Melbourne,　Australia
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Research on the intracellular trafficking mechanisms of transporters to facilitate drug development2012
- Author(s)
  林　久允
- Organizer
  第27回日本薬物動態学会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23790175
[Presentation] 胆汁酸トランスポーターBile salt export pump(BSEP/ABCB11)の細胞膜からの内在化、分解過程に対するユビキチン化の検討2011
- Author(s)
  相田健佑、林久允、稲村香央里、水野忠快、杉山雄一
- Organizer
  第131回日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 胆汁酸トランスポーターBSEPの細胞内ソーティングに対するユビキチン化の役割2011
- Author(s)
  相田健佑、林久允、杉山雄一
- Organizer
  第26年回日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790175
[Presentation] 4-Phenylbutyrate increases the hepatocanalicular expression of MRP2/Mrp2 by modulating its ubiquitination and reduces serum total bilirubin concentration.2011
- Author(s)
  Hisamitsu Hayashi, Tadahaya Mizuno, Reiko Horikawa, Hironori Nagasaka, Takashi Yabuki, Hajime Takikawa, Yuichi Sugiyama
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23790175
[Presentation] 胆汁酸トランスポーターBSEP/ABCB11のAP2との相互作用部位の探索2011
- Author(s)
  林久允、稲村香央里、相田健佑、直井壮太朗、杉山雄一
- Organizer
  第33回胆汁酸研究会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23790175
[Presentation] 胆汁酸トランスポーターBSEPのユビキチン化を介した細胞内ソーティング機構の解析2011
- Author(s)
  相田健佑、林久允、稲村香央里、直井壮太朗、杉山雄一
- Organizer
  第84回生化学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790175
[Presentation] 胆汁酸トランスポーターBSEPの細胞内ソーティングに対するユビキチン化の役割2011
- Author(s)
  相田健佑、林久允、杉山雄一
- Organizer
  第19年回肝病態生理研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790175
[Presentation] 肝機能障害改善薬の開発を指向した胆汁酸トランスポーターBSEP/ABCB11の内在化制御機構の解析2011
- Author(s)
  林久允、稲村香央里、相田健佑、直井壮太朗、杉山雄一
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム(招待講演)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-23790175
[Presentation] AP2 adaptor complex mediates internalization of bile salt export pump and modulates its hepatocanalicular expression and transport function.2011
- Author(s)
  Hisamitsu Hayashi, Kaori Inamura, Kensuke Aida, Sotaro Naoi, Asami Hattori, Takashi Yabuki, Yuichi Sugiyama
- Organizer
  The Liver Meeting 2011
- Place of Presentation
  San Francisco, US
- Data Source
  KAKENHI-PROJECT-23790175
[Presentation] Structural development study of a novel pharmacological chaperon for folding-defective bile salts export pump mutants responsible for PFIC2.2011
- Author(s)
  Takashi Misawa, Hisamitsu Hayashi, Yuichi Sugiyama, Yuichi Hashimoto
- Organizer
  第8回AFMC国際医薬化学シンポジウム
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-23790175
[Presentation] 胆汁酸トランスポーターBile salt export pump (BSEP/ABCB11)の内在化機構の解析2010
- Author(s)
  林久允、稲村香央里、相田健佑、直井壮太朗、杉山雄一
- Organizer
  第32回胆汁酸研究会
- Place of Presentation
  仙台
- Year and Date
  2010-11-06
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Clathrin Adaptor Protein Complex 2 (AP2)-Dependent Internalization Of Bile Salt Export Pump (BSEP/ABCB11)2010
- Author(s)
  Hisamitsu Hayashi, Kaori Inamura, Kensuke Aida, Yuichi Sugiyama
- Organizer
  Falk symposium 175, XXI International Bile Acid Meeting
- Place of Presentation
  Freiburg, Germany
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] CALPAIN-MEDIATED CLEAVAGE NEGATIVELY REGULATES THE EXPRESSION LEVEL OF ABCG12010
- Author(s)
  Natsuki Hori, Hisamitsu Hayashi, Yuichi Sugiyama
- Organizer
  第25回日本薬物動態学会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 胆汁酸トランスポーターBile salt export pump(BSEP/ABCB11)の細胞膜からの分解過程における短鎖ユビキチン化の役割2010
- Author(s)
  林久允、杉山雄一
- Organizer
  第18回肝病態生理研究会
- Place of Presentation
  山形
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Regulation of cell surface expression of multidrug resistance-associated protein 4 (MRP4) through its interaction with PDZ-adaptor proteins2010
- Author(s)
  Hisamitsu Hayashi
- Organizer
  第88回日本生理学会大会/第116回日本解剖学会総会・全国学術集会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Clathrin Adaptor Protein Complex 2 (AP2) Regulates The Internalization Of Bile Salt Export Pump (BSEP/ABCB11)2010
- Author(s)
  Hisamitsu Hayashi, Kaori Inamura, Kensuke Aida, Yuichi Sugiyama
- Organizer
  9^<th> ISSX international meetings
- Place of Presentation
  Istanbul, Turkey
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 脂質トランスポーターABCG1の分解機構の解析2010
- Author(s)
  堀奈津貴、林久允、杉山雄
- Organizer
  Biochemistry and Molecular Biology BMB2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 胆汁酸トランスポーターBile salt export pump(BSEP/ABCB11)の内在化機構の解析2010
- Author(s)
  林久允、稲村香央里、相田健佑、直井壮太朗、杉山雄一
- Organizer
  第32回胆汁酸研究会
- Place of Presentation
  仙台
- Year and Date
  2010-11-06
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Clathrin Adaptor Protein Complex 2 (AP2)-Dependent Internalization Of Bile Salt Export Pump (BSEP/ABCB11).2010
- Author(s)
  Hisamitsu Hayashi, Kaori Inamura, Kensuke Aida, Yuichi Sugiyama.
- Organizer
  Falk symposium 175, XXI International Bile Acid Meeting
- Place of Presentation
  Freiburg, Germany
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Effect of short and middle chain fatty acids on the cell surface expression and transport capacity of Bile Salt Export Pump(BSEP/ABCB11)2010
- Author(s)
  加藤卓也、林久允、杉山雄一
- Organizer
  3rd FEBS Special meeting ATP-Binding Cassette(ABC)Proteins : From Multidrug Resistance to Genetic Diseases
- Place of Presentation
  インスブルック、オーストリア
- Year and Date
  2010-03-02
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 脂質トランスポーターABCG1の分解機構におけるカルパインの関与の検討2010
- Author(s)
  堀奈津貴、林久允、杉山雄
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Association of Clathrin Adaptor Protein Complex 2 (AP2) with Bile Salt Export Pump (BSEP/ABCB11) internalization2010
- Author(s)
  Hisamitsu Hayashi, Kaori Inamura, Kensuke Aida, Sotaro Naoi, Yuichi Sugiyama
- Organizer
  第4回次代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] UBIQUITIN-DEPENDENT DEGRADATION OF ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN ENDOSOMAL-LYSOSOMAL PATHWAY2010
- Author(s)
  Tadahaya Mizuno, Hisamitsu Hayashi, Yuichi Sugiyama
- Organizer
  第25回日本薬物動態学会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 胆汁酸トランスポーターBSEPの内在化機構の解析2010
- Author(s)
  林久允、稲村香央里、杉山雄一
- Organizer
  第25回日本薬剤学会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] ATP-binding cassette transporter A1(ABCA1)の分解に対するユビキチン化の関与2010
- Author(s)
  水野忠快、林久允、杉山雄
- Organizer
  Biochemistry and Molecular Biology BMB2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Clathrin Adaptor Protein Complex 2 (AP2) Regulates The Internalization Of Bile Salt Export Pump (BSEP/ABCB11).2010
- Author(s)
  Hisamitsu Hayashi, Kaori Inamura, Kensuke Aida, Yuichi Sugiyama.
- Organizer
  9th ISSX international meetings
- Place of Presentation
  Istanbul, Turkey
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 肝機能障害改善薬の開発を指向した胆汁酸トランスポーターBile salt export pump(BSEP/ABCB11)の内在化制御機構の解析2010
- Author(s)
  林久允、稲村香央里、相田健佑、直井壮太朗、杉山雄一
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 胆汁酸トランスポーターBile salt export pump(BSEP/ABCB11)の細胞膜発現制御を標的とした新規肝内胆汁うっ滞治療法の開発2010
- Author(s)
  林久允
- Organizer
  第19回日本小児胆汁酸研究会
- Place of Presentation
  東京
- Year and Date
  2010-02-20
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 細胞膜上からのABCA1分解プロセスに対するユビキチン化の関与の検討2010
- Author(s)
  水野忠快、林久允、杉山雄
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 胆汁酸トランスポーター Bile salt export pump(BSEP/ABCB11)の細胞膜発現制御を標的とした新規肝内胆汁うっ滞治療法の開発2010
- Author(s)
  林久允
- Organizer
  第19回日本小児胆汁酸研究会
- Place of Presentation
  山の上ホテル、東京
- Year and Date
  2010-02-20
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Effect of short and middle chain fatty acids on the cell-surface expression and transport capacity of Bile Salt Export Pump(BSEP/ABCB11)2009
- Author(s)
  加藤卓也、林久允、杉山雄一
- Organizer
  16th North American Regional Meeting of ISSX
- Place of Presentation
  ボルティモア、米国
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 胆汁酸トランスポーター Bile salt export pump(BSEP/ABCB11)の内在化過程におけるクラスリンアダプタータンパク質 adaptor protein complex2(AP2)の寄与の解析2009
- Author(s)
  稲村香央里、林久允、杉山雄一
- Organizer
  第31回胆汁酸研究会
- Place of Presentation
  山上会館、東京
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Development of new choleretic drugs targeting the regulation of Bile Salt Export Pump (BSEP/ABCB11) expression at the cell surface2009
- Author(s)
  Hisamitsu Hayashi, Yuichi Sugiyama
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2009-12-01
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Choleretic effect of 4-phenylbutyrate (4PBA) induced by an increase in Bile Salt Export Pump (BSEP/ABCB11) expression at the cell surface2009
- Author(s)
  Hisamitsu Hayashi, Yuichi Sugiyama.
- Organizer
  第5回武田科学振興財団薬科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-05-02
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] CLATHRIN ADAPTOR AP2 REGULATES THE INTERNALIZATION OF BILE SALT EXPORT PUMP(BSEP/ABCB11)2009
- Author(s)
  稲村香央里、林久允、杉山雄一
- Organizer
  第24回日本薬物動態学会
- Place of Presentation
  京都国際会館、京都
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Development of a therapeutic method to combat cholestasis by regulation of the cell-surface expression of Bile salt export pump(BSEP/ABCB11)2009
- Author(s)
  林久允、杉山雄一
- Organizer
  日本薬剤学会 Global Education Seminar East 2009-1^<st>
- Place of Presentation
  東京薬科大学、東京
- Year and Date
  2009-06-23
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Development of a therapeutic method to combat cholestasis by regulation of the cell-surface expression of Bile salt export pump(BSEP/ABCB11)2009
- Author(s)
  Hisamitsu Hayashi, Yuichi Sugiyama
- Organizer
  日本薬剤学会Global Education Seminar East 2009-1^<st>
- Place of Presentation
  東京
- Year and Date
  2009-06-23
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 胆汁酸トランスポーター Bile salt export pump(BSEP/ABCB11)の細胞膜からの分解過程におけるユビキチン化の関与の検討2009
- Author(s)
  林久允、杉山雄一
- Organizer
  第82回生化学大会
- Place of Presentation
  神戸ポートアイランド、神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 短鎖ユビキチン化がBile salt export pump (BSEP/ABCB11)の細胞膜からの分解過程に及ぼす影響2009
- Author(s)
  林久允、杉山雄一
- Organizer
  第31回胆汁酸研究会
- Place of Presentation
  東京
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Choleretic effect of 4-phenylbutyrate(4PBA)induced by an increase in Bile Salt Export Pump(BSEP/ABCB11)expression at the cell surface2009
- Author(s)
  林久允、杉山雄一
- Organizer
  第5回武田科学振興財団薬科学シンポジウム
- Place of Presentation
  高輪プリンス、東京
- Year and Date
  2009-05-25
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 脂肪酸類による Bile salt export pump(BSEP)の輸送機能の亢進作用2009
- Author(s)
  加藤卓也、林久允、杉山雄一
- Organizer
  第24回日本薬剤学会
- Place of Presentation
  静岡県コンベンションアーツセンター、静岡
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 短鎖ユビキチン化が Bile salt export pump(BSEP/ABCB11)の細胞膜からの分解過程に及ぼす影響2009
- Author(s)
  林久允、杉山雄一
- Organizer
  第31回胆汁酸研究会
- Place of Presentation
  山上会館、東京
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Development of new choleretic drugs targeting the regulation of Bile Salt Export Pump(BSEP/ABCB11)expression at the cell surface2009
- Author(s)
  林久允、杉山雄一
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪大学、大阪
- Year and Date
  2009-12-01
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] 胆汁酸トランスポーターBile salt export pump(BSEP/ABCB11)の細胞膜からの分解過程におけるユビキチン化の関与の検討2009
- Author(s)
  林久允、杉山雄一
- Organizer
  第82回生化学大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21790146
[Presentation] Multidrug resistance-associated protein4(MRP4)の細胞膜上発現制御に関わるタンパク質Sorting Nexin 27(SNX27)の機能解析2008
- Author(s)
  林久允, 他
- Organizer
  第23回日本薬剤学会
- Place of Presentation
  北海道
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-20056005
[Presentation] 胆汁酸トランスポーターBSEP/Bsepの輸送機能に関するヒト、ラット間における種差の検討2006
- Author(s)
  林久允ほか
- Organizer
  第14回肝病態生理研究会
- Place of Presentation
  京都
- Year and Date
  2006-05-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Species difference in the transport function of bile salt export pump (BSEP) between humans and rats2006
- Author(s)
  Hayashi H, et. al.
- Organizer
  The 14th Japanese Study Group for the Pathophysiology of the liver
- Place of Presentation
  Kyoto
- Year and Date
  2006-05-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] 胆汁酸トランスポーターBSEPの内在化モチーフの探索
- Author(s)
  林　久允
- Organizer
  第20回肝病態生理研究会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23790175
[]
[]
[]

1. KUSUHARA Hiroyuki (00302612)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
2. 水野忠快 (90736050)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. MAEDA Kazuya (00345258)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SUGIYAMA Yuichi (80090471)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 大貫玲子 (70361607)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 戸川貴夫 (10792814)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
7. 今川和生 (40708509)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
8. KUMAGAI Yuji (40215017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUWA Toshio (20383664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHITARA Yoshihisa (00306656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TAKIKAWA Hajime (70197226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ITO Koichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 杉浦時雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 清水誠一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 武部貴則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 小川絵里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Hisamitsu 林 久允

HAYASHI Hisamitsu 林 久允

Research Projects

Research Products

Co-Researchers

Study to simplify disease models for pediatric liver diseasesPrincipal Investigator

Principal Investigator

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健康長寿社会の実現に資する革新的低コスト医療創製基盤の構築Principal Investigator

Principal Investigator

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Review Section

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Analysis of molecular mechanisms in the development of pediatric cholestatic liver diseasePrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Development of methods to realize medical theapy by enhancing the function of ABC transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel diagnostic method for refractory pediatric liver diseasesPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Development of a strategy of drug development for ABC transporter-related diseasesPrincipal Investigator

Principal Investigator

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Research Institution

Development of novel therapeutic method for ABC transporter-related diseasesPrincipal Investigator

Principal Investigator

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Research Institution

Elucidation of the transporters, and integration research of their molecular entities and activities for the drug transport in the brain and kidneys

Principal Investigator

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Research Institution

Understanding of mechanism underlying intracellular sorting of hepatocanalicular transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

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New drug therapy of the transporter-related diseases through the modulation of membrane traffickingPrincipal Investigator

Principal Investigator

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Research Institution

薬剤応答性における薬物トランスポートソームの動的制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of probe drugs for the evaluation of the functions of drug transporters in vivo in humans

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

トランスポートソームの機能制御による医薬品体内動態の制御

Principal Investigator

Project Period (FY)

Hayashi Hisamitsu 林久允

HAYASHI Hisamitsu 林久允

[Book] 「トランスポートソーム生体膜輸送機構の全体像に迫る (遺伝子医学MOOK19)」金井好克編2011

[Book] トランスポートソーム生体膜輸送機構の全体像に迫る基礎,臨床,創薬応用研究の最新成果