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Sugiyama Yuichi  杉山 雄一

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SUGIYAMA Yuichi  杉山 雄一

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Researcher Number 80090471
Other IDs
External Links
Affiliation (Current) 2021: 城西国際大学, 薬学部, 特別栄誉教授
2021: 国立研究開発法人理化学研究所, 科技ハブ産連本部, 特別招聘研究員
Affiliation (based on the past Project Information) *help 2018 – 2020: 国立研究開発法人理化学研究所, 科技ハブ産連本部, 特別招聘研究員
2015 – 2017: 国立研究開発法人理化学研究所, イノベーション推進センター, 特別招聘研究員
2013 – 2014: 独立行政法人理化学研究所, イノベーション推進センター, 特別招聘研究員
2012: 独立行政法人理化学研究所, 杉山特別研究室, 特別招聘研究員
2007 – 2011: The University of Tokyo, Graduate School of Pharmaceutical Sciences, Professor … More
2007: The University of Tokyo, 大学院・薬学系研究所, 教授
2006: 東京大学, 大学院薬学系研究科, 教授
2005: 東京大学, 薬学系研究科, 教授
1997 – 2005: Graduate School of Pharm.Sci., The Univ.of Tokyo Professor, 大学院・薬学系研究科, 教授
2004: The University of Tokyo, Graduate School of Pharmaceutical Sciences, Professor, 大学院薬学研究科, 教授
1991 – 1998: Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授
1996: 神戸薬科大学, 薬学部, 教授
1992 – 1993: 東京大学, 薬学部, 助教授
1990: Fac. Pharm. Sci., Univ. of Tokyo, Associate Professor, 薬学部・附属病院, 助教授
1988 – 1990: Faculty of Pharmaceutical Science University of Tokyo, 薬学部, 助教授
1988: Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Associated Professor, 薬学部・製剤学, 助教授
1988: 東京大学, 薬学部製剤学, 助教授
1987: 東京大学, 薬学部, 助手
1987: 東京大学, 薬学部・製剤学, 助手
1986: 東京大学, 薬学部・製剤学教室, 助手 Less
Review Section/Research Field
Principal Investigator
Biological pharmacy / Physical pharmacy / 応用薬理学・医療系薬学 / Biological Sciences / Medical pharmacy / 医薬分子機能学 / Drug development chemistry / Basic Section 47060:Clinical pharmacy-related
Except Principal Investigator
Physical pharmacy / 応用薬理学・医療系薬学 … More / Science and Engineering / Biological Sciences / Laboratory animal science / 医薬分子機能学 / Biomedical engineering/Biological material science / Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Less
Keywords
Principal Investigator
胆汁排泄 / トランスポーター / cMOAT / MRP / 有機アニオン / biliary excretion / transporter / 薬物間相互作用 / MRP2 / 多剤耐性 … More / ファーマコキネティクス / 輸送担体 / 体内動態 / 血液脳関門 / organic anion / ビンクリスチン / 生理学的薬物速度論 / oatp / MLP / ドラッグデリバリーシステム / 薬物速度論 / OATP / OAT / Pharmacokinetics / 能動輸送 / OATP2 / P-糖蛋白 / 肝輸送 / 血液-脳脊髄液関門 / 薬物代謝酵素 / 遺伝的多型 / 一次性能動輸送 / cDNAクローニング / P-450 / 尿中排泄 / 薬物代謝 / ABC輸送担体 / 細胞内挙動 / 薬剤反応性 / 遺伝子多型 / 薬物動態 / 生理学的薬物速度論モデル / 薬物トランスポーター / フェノタイピング / CYP3A4 / モデリング&シミュレーション / 個人間変動 / down-regulation / 血液・脳関門 / 血液・脳脊髄液関門 / 血液-脳関門 / 脳毛細血管内皮細胞 / Blood-Brain Barrier / 血液脳脊髄液関門 / 担体輸送 / MRK-16 / 肝取り込み / クリアランス / ABC transporter / Ntcp / ABCトランスポーター / 遺伝子クローニング / 肝胆系輸送 / hepatobiliary transport / エンドサイトーシス / MRP3 / OCT / pharmacophore / Mrps / P糖蛋白 / 肝潅流 / ATP依存性排泄 / フエノチアジン / 胆管側膜 / 脈絡叢 / 抗癌剤 / 化学療法 / 最大耐用量 / 血中濃度下面積(AUC) / 骨髄毒性 / 酵素の多様性 / 遺伝子発現の調節機構 / 遺伝子診断法 / 代替法 / 薬物輸送担体 / 5-FU / ファーマコダイナミクス / AUC / CPT-11 / 有機アニオン輸送担体 / Dubin-Johnson症候群 / EHBR / 変異機構 / アンチセンス / ターゲティング / CYPアイソザイム / 薬学 / 抗がん剤 / DNAメチル化 / ゲノム / テルミサルタン / UGT / オルメサルタン / プラバスタチン / プローブ薬 / クリアランスの律速段階 / ヒト肝細胞 / ヒト腎スライス / シメチジン / MATEs / 律速段階 / 肝クリアランス / atorvastatin / 薬剤感受性 / 腎スライス / MATE / PET/SPECTプローブ / 創薬支援システム / バーチャルクリニカルスタディ / 受容体介在性エンドサイト-シス / 上皮成長因子(EGF) / ダウンレギュレ-ション / 内在化 / receptor-mediated endocytosis / epidermal growth factor (EGF) / internalization / βーラクタム抗生物質 / β-ラクタム抗生物質 / ドラッグデリバリ-システム / Blood-Cerebrospinal Fluid Barrier / beta-lactam antibiotic / ペプチド / ニューキノロン / 抗エイズ薬 / 脈絡叢上皮細胞 / Blood-CSF Barrier / Peptide / New quinolone / Anti-AIDS drug / Physiological Pharmacokinetics / モノクローナル抗体 / MDR / 単離脈絡叢 / 脳脊髄液関門 / 脳血液関門 / AZT / DDI / vincristine / Multi-drug resistance / P-glycoprotein / Monoclonal antibody / Vincristine / Physiological pharmacokinetics / 胆管側膜透過 / グローニング / Dubin Johnson症候群 / 遺伝的変異 / 胆管側模透過 / クローニング / ペプチド性化合物 / 輸送担体欠損ラット / bile canalicular membrane / primary active transport / colning / Dubin Johnson Syndrome / heredital defect / サイトカイン / ポリペプチド / 増殖因子 / 肝細胞増殖因子 / 上皮成長因子 / Cytokine / Polypeptide / Growth Factor / Drug delivery system / Clearance / Epidermal growth factor / Hepatocyte growth factor / 肝ミクロソーム / P450発現系 / 胆管側膜小胞 / drug metabolism / hepatic microsomes / recombinant P-450 / hepatic uptake / ABC輸送担 / multidrug resistance / CMOAT / 発現誘導 / ABC transpoter / organic anions / induction / 個人差 / 種差 / 遺伝子発現系 / 異物解毒機構 / 異物解毒 / drug disposition / interindividual difference / species difference / gene expression system / detoxification system / ドラックデリバリーシステム / 生理活性蛋白質 / レセプター / Intracellular sorting / Drug Delivery System / iologically Active Proteins / Receptor / Endocytosis / oatp1 / oat3 / Transporter / Organic anion / Biliary excretion / Urinary excretion / 経細胞輸送 / 上皮細胞 / ベクトル輸送 / アミノ酸トランスポーター / 尿細管 / 腎臓 / 極性細胞 / 上皮輸送 / 膜ソーティング / 蛋白間相互作用 / MDCK細胞 / transcellular transport / epithelial cells / vectorial transport / amino acid transporter / 3次元構造活性相関 / 排出ポンプ / Oat3 / Oatp14 / OAT3 / MRP1 / blood-brain barrer / blood-CSF barrier / CAMDAS / セリバスタチン / ビグアニド系抗糖尿病薬 / OCT1 / OCT2 / drug-drug interaction / cerivastatin / biguanides / 排出輸送 / ファーマコフォア / 基質選択性 / blood-brain barrier / efflux transport / substrate specificity / 代謝酵素 / 利尿薬 / HIV治療薬 / 腎排泄 / 小腸吸収 / Mrp3 / Mrp4 / SULT / metabolic enzymes / transporters / diuretics / anti-HIV drugs / renal excretion / drug-drue interaction / 上皮細胞増殖因子 / EGF / 生理活性ペプタイド / リセプター / 受容体 / ダウンレギュレーション / ベータエンドルフィン / epidermal growth factor / biologically active peptide / receptor / -endorphine / clearance / 仮想臨床試験 … More
Except Principal Investigator
トランスポーター / 薬物速度論 / 胆汁排泄 / ABCトランスポーター / Pharmacokinetics / トランスジェニックマウス / 血液脳関門 / pharmacokinetics / 脳 / 血液-脳関門 / 血液-脳脊髄液関門 / チトクロームP450 / がん原物質活性化 / CYP1A1 / P450アロマターゼ / 有機アニオン / 有機アニオントランスポーター / 尿細管分泌 / 血液脳脊髄液関門 / 薬剤反応性 / 抗癌剤 / ヒト / 薬物送達システム / Drug delivery system / グルコ-ス / muscimol / glucose / P450 / ポリオウイルス / ウイルス受容体 / ドラッグデリバリー / Blood-brain barrier / Poliovirus / Virus receptor / Organ tropism / drug delivery / transporter / receptor / tissue targeting / blood-brain barrier / cloning / efflux pump / Brain / MRP / cMOAT / ベンゾジアゼピン / 脳毛細血管内皮細胞 / 脈絡叢上皮細胞 / P-糖蛋白 / ビンクリスチン / 遺伝子導入動物 / CYP2B6 / 一酸化窒素合成酵素 / 受容体介在性内在化 / ターゲティング / デリバリー / ウイルスベクター / G-CSF / 遺伝子導入 / 能動輸送 / 基質認識 / 相互作用 / シンクロナイゼーション / ベクトル輸送 / Oat3 / Oatp3 / RST / 性差 / 再呼吸 / プロドラッグ / Oatp1 / 薬物間相互作用 / 小腸上皮細胞 / 排出輸送 / 生理学 / 薬理学 / コレステロール / 尿酸 / 胆汁 / 翻訳後修飾 / 相互作用蛋白質 / PFIC / ABCC / MRP2 / 酸化的ストレス / 内在化 / プロテインキナーゼ / ABCB11 / BSEP / マウス / ファーマコキネテックス / 薬剤感受性 / スクリーニングシステム / リポソーム / マクロファージ / ライソゾーム / オプソニン / 補体レセプター / リポソ-ム / 細胞内運命 / DDS / クリアランス / 補体 / Liposome / Macrophage / Lysosome / Opsonin / Complement receptor / 培養神経細胞 / 分離神経細胞 / 3ー0ーmethylglucose / 2ーdeoxyglucose / 3ーOーmethylglucose / cerebellar granule cells in monolayer culture / isolated brain cells / 3-o-methylglucose / 2-deoxyglucose / 外挿 / 動物種差 / 遺伝子 / 薬物代謝 / 遺伝子相同性 / 実験動物 / 系統差 / アニマルスケールアップ / 遺伝的相同性 / 遺伝情報 / 薬物代謝酵素 / 薬物代謝能 / 疾患遺伝子 / 膜酵素 / 肝臓薬物代謝酵素 / 遺伝子地図 / ジーンバンク / 動物脳シナプス膜脂質 / EXTRAPOLATION / SPECIES DIFFERENCES / GENE / PHARMACOKINETICS / GENETIC HOMOLOGY / LABORAATORY ANIMALS / STRAIN DIFFERENCES / ANIMAL SCALE UP / 薬物体内動態 / 生理学的モデル / 細胞膜透過 / 薬物吸収 / 薬物ターゲッティング / ペプチド薬物 / 鎮痛薬 / Physiological model / Cell membrane permeation / Drug absorption / Drug targeting / Peptide drug / サルモネラ菌 / 変異原性試験 / 代謝的活性化 / 遺伝子多型 / 肺がん / がん原物質 / DNAアダクト / 発現制御 / 発現系 / CYP1A2 / アロマターゼ / Ahレセプター / 遺伝子導入マウス / CYP3A4 / Salmonella typhimurium / Mutation assay / Metabolic activation / Genetic polymorphism / Lung cancer / 細胞接着因子 / 癌細胞 / 転移 / 輸送担体 / ウイルス感染 / モノクローナル抗体 / Cell adhesion molecule / Drug delivery / Tumor cells / Transport carrier / effux pump / レセプター / 組織標的化 / ウイルス製剤 / ワクチン / 臓器選択性 / Vaccine / Blood-brain barrier : / Transgenic mouse / トキシコキネティクス / ファーマコキネティクス / I型薬剤 / サル / ヌードマウス / ヒト癌 / トキシコテネティクス / I型抗癌剤 / 濃度時間積 / マイトマイシンC / サイクロフォスファミド / シスプラチン / toxicokinetics / anticancer drug / type I agent / monkey / human / mouse / human neoplasm / 骨粗鬆症 / アパタイト / バイオマテリアル / 徐放化 / 人工骨 / インテリジェントマテリアル / 骨密度 / 骨粗鬆症, / 薬物送達システム, / アパタイト, / バイオマテリアル, / 徐放化, / 人工骨, / インテリジェントマテリアル, / 除放化 / Osteoporosis / apatite / biomaterials / sustained drug release / atificial bone / intelligent materials / bone mineral density / 胆汁排出 / CMOAT / 異物解毒 / 発現誘導 / GS-Xポンプ / 胆管側膜透過 / 有機アニオン輸送担体 / ABC輸送担体 / MRPファミリー / biliary excretion / detoxification / ABC transporter / organic anions / induction / GS-X pump / 強心配糖体 / ウアバイン / 心筋収縮力 / Na^+,K^+ATPase / 心臓灌流実験 / グルコース代謝 / ベンゾジアゼピンレセプター / Na^+ / K^+ATPase / Na^+,Ka^+ATPase / Cardiac glycosides / Ouabain / Positive inotropic action / Na^+,K^+ ATPase / Isolated perfused heart / Glucose metabolism / 血液脳脊髄関門 / 肝障害 / 腎障害 / 脈絡叢 / 薬物脳移行 / 腎障害ラット / イミブラミン / デシプラミン / DL-プロプラノロール / cerebrospinal fluid / choroid plexus / renal failure / hepatic failure / クロナゼパム / デオキシグルコ-ス / ゾルピデム / 代謝 / デオキシグルコース / グルコース / Benzodiazepine / clonazepam / deoxyglucose / zolpidem / metabolism / brain / 個体間変動 / 母集団薬物動態解析 / カルバマゼピン / 生理学的薬物動態モデル / 個人間変動 / 母集団薬物動態解析法 / 有機アニオントランスポータ / CYP2C9 / アデホビル / セロトニントランスポータ / 薬学 / 臨床 / 内在性基質 / 薬物相互作用 / 生理学的薬物速度論モデル / バイオマーカー Less
  • Research Projects

    (57 results)
  • Research Products

    (338 results)
  • Co-Researchers

    (116 People)
  •  肝OATP内在性基質の体内動態メカニズム解析による生理学的薬物速度論モデルの確立Ongoing

    • Principal Investigator
      吉門 崇
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Yokohama College of Pharmacy
  •  薬物組織移行・薬効・副作用の支配要因の変動を考慮したバーチャル臨床試験系の確立Principal InvestigatorOngoing

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Database for variation of pharmacokinetic and pharmacodynamic parameters in various diseasesOngoing

    • Principal Investigator
      千葉 康司
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Yokohama College of Pharmacy
  •  Development of quantitative prediction methods for alteration in pharmacokinetics caused by interindividual variability in transporter function and transporter-mediated drug-drug interactionPrincipal Investigator

    • Principal Investigator
      Sugiyama Yuichi
    • Project Period (FY)
      2012 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Medical pharmacy
    • Research Institution
      Institute of Physical and Chemical Research
  •  異物解毒システムの個人間変動要因に基づいた抗癌剤処方の最適化戦略の開発Principal Investigator

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  薬物動態・薬効の変動に関与する薬物トランスポーターの遺伝子多型の包括的実証研究Principal Investigator

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Development of probe drugs for the evaluation of the functions of drug transporters in vivo in humansPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Medical pharmacy
    • Research Institution
      The University of Tokyo
  •  Analysis of the function and regulatory mechanism of drug transportsome

    • Principal Investigator
      SUZUKI Hiroshi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Development of the quantitative prediction method of pharmacokinetics with considering the function of metabolic enzymes and transportersPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Medical pharmacy
    • Research Institution
      The University of Tokyo
  •  抗癌剤のテーラーメード医療確立のための異物解毒システムにおける個人差の解明

    • Principal Investigator
      楠原 洋之
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  New strategy for the drug development of CNS acting drugs by regulating drug transport across the blood-brain barrierPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  肝・腎トランスポーターによる機能分担と活性調節に関する分子シンクロナイゼーション

    • Principal Investigator
      楠原 洋之
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      The University of Tokyo
  •  Drug design based on the substrate specificity of the efflux transporters expressed in the blood-brain barrierPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      The University of Tokyo
  •  Development of the system for prediction of drug-drug interactions in hepatobiliary transport processPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      The University of Tokyo
  •  Analysis of the vectorial transport of amino acid and drugs in epithelial cells.Principal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  肝細胞膜に発現するトランスポーターの分子機能におけるシンクロナイゼーション

    • Principal Investigator
      加藤 将夫
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Science and Engineering
    • Research Institution
      The University of Tokyo
  •  Metabolic activation of procarcinogens and cancer risk

    • Principal Investigator
      KAMATAKI Tetsuya
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  Analysis of the factors governing the elimination route of therapeutic agentsPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Graduate School of Pharmaceutical Sciences, The University of Tokyo
  •  Role of hepatic transporters in the detoxificationPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Biological pharmacy
    • Research Institution
      Graduate School of Pharmaceutical Sciences, The University of Tokyo
  •  Development of recombinant proteins with an aim to increase their therapeutic activity by the regulation of intracellular sortingPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      The University of Tokyo
  •  胆管側膜上有機アニオン輸送担体および関連蛋白とチャンネル機能の協関Principal Investigator

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  受容体介在性機構による遺伝子導入法の速度論的評価(組み換え型ウイルスベクターと非ウイルスベクターの細胞内動態の解析)

    • Principal Investigator
      鈴木 洋史
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Physical pharmacy
    • Research Institution
      The University of Tokyo
  •  アンチセンスDNAの至適投与法の確立を目指した体内動態、細胞内動態解析法の開発Principal Investigator

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      The University of Tokyo
  •  異物解毒の分子基盤:代謝・排泄能の分子から個体への予測Principal Investigator

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  Role of hepatic transporters in the detoxificationPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Biological pharmacy
    • Research Institution
      Graduate School of Pharmaceutical Sciences, The University of Tokyo
  •  Analysis of multiplicity and polymorphism of drug transporters expressed in the liver.Principal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  Analysis of molecular basis for the presence of interindividual difference in the biliary excretion of xenobiotics

    • Principal Investigator
      SUZUKI Hiroshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Graduate School of Pharmaceutical Sciences, The University of Tokyo
  •  胆管側膜上有機アニオン輸送担体のクローニングとチャンネル機能の構造Principal Investigator

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  薬物解毒(代謝・排泄)能力の予測:分子から個体へPrincipal Investigator

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  Development of a method to predict in vivo drug metabolism and excretion from in vitro data with human hepatic tissues and/or recombinant proteinsPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      Graduate School of Pharmaceutical Sciences, The University of Tokyo
  •  Endogenous signal-responsive drug release from bioactive bone cement

    • Principal Investigator
      OTSUKA Makoto
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Kobe Pharmaceutical Univesity
  •  抗癌剤の前臨床データを基にしたヒトにおける動態、最大耐用量、抗腫瘍効果の予測Principal Investigator

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Clarification of organ specific transport mechanism of druge and its application to regulation of pharmacokinetics and pharmacodynamics

    • Principal Investigator
      TSUJI Akira
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      Kanazawa University
  •  Development of Pharmacokinetic and Safety Assessment of in vivo Virus Infection and Vaccine Therapy

    • Principal Investigator
      TERASAKI Tetsuya
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University
      The University of Tokyo
  •  A new approach for prediction of clinical efficacy of anticancer drugs based on toxicokinetic and pharmacokinetic analysis

    • Principal Investigator
      OHNISHI Yasuyuki
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  抗癌剤の最適投与計画の作成:骨髄毒性の定量化とその回避Principal Investigator

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  薬物動態の分子基盤:解毒(代謝・排泄)能力の予測Principal Investigator

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  Prediction of hepatobiliary transport of drugs : Contribution of carrier-mediated transport in the detoxication of xenobioticsPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Faculty of Pharmaceutical Sciences, The University of Tokyo
  •  Drug Delivery to the Brain Using Cell Adhesion Molecule

    • Principal Investigator
      TERASAKI Tetsuya
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Department of Pharmacutics, Faculty of Pharmaceutical Sciences, University of Tokyo,
  •  Development of drug delivery systems for cytokines with an aim of efficient exertion of their pharmacological effectPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Faculty of Pharmaceutical Sciences, University of Tokyo
  •  チトクロームP450を利用したがん原性のシュミレーションと発がんの感受性の解析

    • Principal Investigator
      KAMATAKI Tetsuya
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  Prediction and control effectiveness and safety of a drug by means of pharmacokinetics based on physiological and biochemical mechanism of its disposition in body.

    • Principal Investigator
      HANANO Manabu
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      Nihon University
  •  抗癌剤の腫瘍組織へのターゲッティングを目指した組織分布機構の速度論的解明ーP糖蛋白の関与する輸送解析ーPrincipal Investigator

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  血液-脳関門における制癌剤透過機構の解明:P-糖蛋白機能発現の定量的評価

    • Principal Investigator
      鈴木 洋史
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      The University of Tokyo
  •  A COMPREHENSIVE RESEARCH FOR EXTRAPOLATION--GENETIC HOMOLOGY BETWEEN HUMAN BEINGS AND LABORATORY ANIMALS

    • Principal Investigator
      KASAI Noriyuki
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Laboratory animal science
    • Research Institution
      TOHOKU UNIVERSITY
      Hokkaido University
  •  Analysis of drug disposition in the central nervous system based on the transport characteristics across the blood-brain barrier and blood-cerebrospinal fluid barrier : Special focus on PeptidePrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      University of Tokyo
  •  Development of the drug delivery system for brain and cancer using the inhibitory effect of some drugs on the active efflux : Application of physiological pharmacokinetics.Principal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      University of Tokyo
  •  抗癌剤の腫瘍組織へのタ-ゲッティングを目指した組織分布機構の速度論的解明Principal Investigator

    • Principal Investigator
      杉山 雄一
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  Kinetic analysis of receptor-mediated endocytosis of polypeptide hormonesPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi, HANANO Manabu
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      University of Tokyo
  •  Development of a drug delivery system using the receptors located on the cerebral microvessels : An approach based on the physiological pharmacokinetio model.Principal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi, 花野 学
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      University of Tokyo
  •  Development of intracellular drug delivery system utilizing liposomes

    • Principal Investigator
      KIWADA Hiroshi
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      University of Tokushima
  •  Quantitative analysis of Pharmacological effects of psychiatic drugs using neuronal cultured cells

    • Principal Investigator
      SAWADA Yasufumi
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      University of Tokyo
  •  Kinetic Analysis of the CNS Disposition of Drugs in the Renal and Hepatic Failure

    • Principal Investigator
      IGA Tatsuji
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      The University of Tokyo
  •  Quantitative relationship between in vivo receptor occupancy of psychotropic and the change of glucose utilization in brain

    • Principal Investigator
      SAWADA Yasufumi
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Tokyo University
  •  Kinetical analysis of pharmacodynamics based on drug-receptor interactions

    • Principal Investigator
      HANANO Manabu
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      University of Tokyo
  •  Pharmacokinetic analysis of disposition of biologically active peptide in the body.Principal Investigator

    • Principal Investigator
      SUGIYAMA Yuichi
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Tokyo University
  •  マウスとヒトにおける抗癌剤の比較薬理学的解析

    • Principal Investigator
      INABA Makoto
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

  • [Book] Excretion systems in: "Encyclopedia of drug metabolism and interactions"2012

    • Author(s)
      Maeda K, and Sugiyama Y
    • Publisher
      John Wiley & Sons, Inc., New York
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Extrapolation of In Vivo Hepatic Clearance From In Vitro Uptake Clearance by Suspended Human Hepatocytes for Anionic Drugs With High Binding to Human Albumin: Improvement of In Vitro-to-In Vivo Extrapolation by Considering the "Albumin-Mediated" Hepatic Uptake Mechanism on the Basis of the "Facilitated-Dissociation Model"2019

    • Author(s)
      Kim Soo-Jin、Lee Kyeong-Ryoon、Miyauchi Seiji、Sugiyama Yuichi
    • Journal Title

      Drug Metab Dispos

      Volume: 47 Pages: 94-103

    • DOI

      10.1124/dmd.118.083733

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06608, KAKENHI-PROJECT-19H03392
  • [Journal Article] Expanded Physiologically-Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction2019

    • Author(s)
      Asaumi R, Menzel K, Lee W, Nunoya KI, Imawaka H, Kusuhara H, Sugiyama Y
    • Journal Title

      CPT Pharmacometrics Syst Pharmacol

      Volume: 8 Pages: 845-857

    • DOI

      10.1002/psp4.12457

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03392
  • [Journal Article] Comparative and quantitative assessment on statin efficacy and afety: insights into inter-statin and inter-individual variability via dose- and exposure-response relationships2019

    • Author(s)
      Iwaki Y, Lee W, Sugiyama Y
    • Journal Title

      Expert Opin Drug Metab Toxicol

      Volume: 15 Pages: 897-911

    • DOI

      10.1080/17425255.2019.1681399

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03392
  • [Journal Article] Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine2019

    • Author(s)
      Nishiyama K, Toshimoto K, Lee W, Ishiguro N, Bister B, Sugiyama Y
    • Journal Title

      CPT Pharmacometrics Syst Pharmacol

      Volume: 8 Pages: 396-406

    • DOI

      10.1002/psp4.12398

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03392
  • [Journal Article] PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B32018

    • Author(s)
      Yoshikado T., Toshimoto K., Maeda K., Kusuhara H., Kimoto E., Rodrigues AD., Chiba K., Sugiyama Y.
    • Journal Title

      CPT: Pharmacometrics & Systems Pharmacology

      Volume: 7 Pages: 739-747

    • DOI

      10.1002/psp4.12348

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08470, KAKENHI-PROJECT-17K15536, KAKENHI-PROJECT-17H04100
  • [Journal Article] Preincubation- dependent and long-lasting inhibition of organic anion transporting polypeptide (OATP) and its impact on drug-drug interactions.2017

    • Author(s)
      Shitara Y, and Sugiyama Y.
    • Journal Title

      Pharmacol Ther pii:S0163-7258

      Volume: 17 Pages: 30066-30069

    • DOI

      10.1016/j.pharmthera.2017.02.042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-08022017

    • Author(s)
      Ito M, Kusuhara K, Ose A, Kondo T, Tanabe K, Nakayama H, Horita S, Fujita T, Sugiyama Y.
    • Journal Title

      AAPS Journal

      Volume: 19 Pages: 286-297

    • DOI

      10.1208/s12248-016-9992-0

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-26293032, KAKENHI-PROJECT-26460210
  • [Journal Article] Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data.2017

    • Author(s)
      Kanamitsu K, Nozaki Y, Nagaya Y, Sugiyama Y, Kusuhara H.
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 32 Pages: 135-144

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Prediction of inter-individual variability on the pharmacokinetics of CYP2C8 substrates in human2017

    • Author(s)
      Haraya Kenta、Kato Motohiro、Chiba Koji、Sugiyama Yuichi
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 32 Pages: 277-285

    • DOI

      10.1016/j.dmpk.2017.09.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08470
  • [Journal Article] Small-dosing clinical study: Pharmacokine- tic, pharmacogeno- mics (SLCO2B1 and ABCG2), and interaction (atorvastatin and grapefruit juice) profiles of 5 probes for OATP2B1 and BCRP.2017

    • Author(s)
      Kashihara Y, Ieiri I, Yoshikado T, Maeda K, Fukae M, Kimura M, Hirota T, Matsuki S, Irie S, Izumi N, Kusuhara H, Sugiyama Y.
    • Journal Title

      J Pharm Sci

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Comparison of methods for estimating unbound intracellular-to-medium concentration ratios in rat and human hepatocytes using statins.2017

    • Author(s)
      Yoshikado T, Toshimoto K, Nakada T, Ikejiri K, Kusuhara H, Maeda K, Sugiyama Y.
    • Journal Title

      Drug Metab Dispos

      Volume: 印刷中

    • DOI

      10.1124/dmd.116.074823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side Effects.2017

    • Author(s)
      Toshimoto K, Tomaru A, Hosokawa M, Sugiyama Y.
    • Journal Title

      Pharm Res.

      Volume: 印刷中 Pages: 1584-1600

    • DOI

      10.1007/s11095-017-2153-z

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-16K08378, KAKENHI-PROJECT-16K18972
  • [Journal Article] Possibility of Predicting Serotonin Transporter Occupancy From the In?Vitro Inhibition Constant for Serotonin Transporter, the Clinically Relevant Plasma Concentration of Unbound Drugs, and Their Profiles for Substrates of Transporters2017

    • Author(s)
      Yahata Masahiro、Chiba Koji、Watanabe Takao、Sugiyama Yuichi
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 106 Pages: 2345-2356

    • DOI

      10.1016/j.xphs.2017.05.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08470
  • [Journal Article] Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches.2017

    • Author(s)
      Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y.
    • Journal Title

      J Pharm Sci

      Volume: 24 Pages: 30084-30089

    • DOI

      10.1016/j.xphs.2017.02.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Analysis of the Change in the Blood Concentration-Time Profile Caused by Complex Drug-Drug Interactions in the Liver Considering the Enterohepatic Circulation: Examining Whether the Inhibition Constants for Uptake, Metabolism, and Biliary Excretion Can be Recovered by the Analyses Using Physiologically Based Pharmacokinetic Modeling2017

    • Author(s)
      Toshimoto K, Tomoda Y, Chiba K, Sugiyama Y.
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 印刷中 Pages: 2727-2738

    • DOI

      10.1016/j.xphs.2017.04.057

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-17K08470, KAKENHI-PROJECT-16K18972
  • [Journal Article] Is Ethnic Variability in the Exposure to Rosuvastatin Explained Only by Genetic Polymorphisms in OATP1B1 and BCRP or Should the Contribution of Intrinsic Ethnic Differences in OATP1B1 Be Considered?2017

    • Author(s)
      Sugiyama Y, Maeda K, Toshimoto K.
    • Journal Title

      J Pharm Sci

      Volume: 印刷中 Pages: 2227-2230

    • DOI

      10.1016/j.xphs.2017.04.074

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-16K18972
  • [Journal Article] Quantitative Analysis of Complex Drug&-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.2017

    • Author(s)
      Kim SJ, Toshimoto K, Yao Y, Yoshikado T, Sugiyama Y.
    • Journal Title

      J Pharm Sci

      Volume: 印刷中

    • DOI

      10.1016/j.xphs.2017.04.063

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Estimation of Interindividual Variability of Pharmacokinetics of CYP2C9 Substrates in Humans2017

    • Author(s)
      Chiba K, Shimizu K, Kato M, Miyazaki T, Nishibayashi T, Terada K, Sugiyama Y.
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 印刷中 Pages: 2695-2703

    • DOI

      10.1016/j.xphs.2017.04.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-17K08470
  • [Journal Article] Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure.2016

    • Author(s)
      Ose A, Toshimoto K, Ikeda K, Maeda K, Yoshida S, Yamashita F, Hashida M, Ishida T, Akiyama Y, Sugiyama Y.
    • Journal Title

      J Pharm Sci

      Volume: 105 Pages: 2222-2230

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Prediction of Inter-Individual Variability on the Pharmacokinetics of Cyp1a2 Substrates in Non-Smoking Healthy Volunteers.2016

    • Author(s)
      Haraya K, Kato M, Chiba K, Sugiyama Y.
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 31 Pages: 276-284

    • DOI

      10.1016/j.dmpk.2016.03.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Investigation of Endogenous Compounds Applicable to Drug - Drug Interaction Studies Involving the Renal Organic Anion Transporters, Oat1 and Oat3, in Humans.2016

    • Author(s)
      Tsuruya Y, Kato K, Sano Y, Imamura Y, Maeda K, Kumagai Y, Sugiyama Y, Kusuhara H.
    • Journal Title

      Drug Metab Dispos

      Volume: 44 Pages: 1925-1933

    • DOI

      10.1124/dmd.116.071472

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Radiosynthesis of novel pitavastatin derivative ([18F]PT V-F1) as a tracer for hepatic OATP using a one-pot synthetic procedure. J Labelled Comp Radiopharm2016

    • Author(s)
      Kimura H, Yagi Y, Arimitsu K, Maeda K, Ikejiri K, Takano J, Kusuhara H, Kagawa S, Ono M, Sugiyama Y, Saji H.
    • Journal Title

      J Labelled Comp Radiopharm.

      Volume: 59 Pages: 565-575

    • DOI

      10.1002/jlcr.3464

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-26461816
  • [Journal Article] Usefulness of a Model-Based Approach for Estimating in Vitro P-Glycoprotein Inhibition Potency in a Transcellular Transport Assay.2016

    • Author(s)
      Kishimoto W, Ishiguro N, Ludwig- Schwellinger E, Ebner T, Maeda K, Sugiyama Y.
    • Journal Title

      J Pharm Sci

      Volume: 105 Pages: 891-896

    • DOI

      10.1016/j.xphs.2015.11.006

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Explication of Definitional Description and Empirical Use of Fraction of Orally Administered Drugs Absorbed From the Intestine (Fa) and Intestinal Availability (Fg): Effect of P-glycoprotein and CYP3A on Fa and Fg.2016

    • Author(s)
      Tanaka Y, Kitamura Y, Maeda K, Sugiyama Y.
    • Journal Title

      J Pharm Sci.

      Volume: 105 Pages: 431-442

    • DOI

      10.1016/j.xphs.2015.11.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Microdosing and Other Phase 0 Clinical Trials: Facilitating Translation in Drug Development.2016

    • Author(s)
      Burt T, Yoshida K, Lappin G, Vuong L, John C, de Wildt SN, Sugiyama Y, Rowland M.
    • Journal Title

      Clin Transl Sci

      Volume: 9 Pages: 74-88

    • DOI

      10.1111/cts.12390

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Clarification of the Mechanism of Clopidogrel- Mediated Drug-Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information.2016

    • Author(s)
      Nakanishi T, Haruta T, Shirasaka Y, Tamai I
    • Journal Title

      Drug Metab Dispos

      Volume: 39(1) Pages: 1622-1632

    • DOI

      10.1124/dmd

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-21390044, KAKENHI-PROJECT-24229002
  • [Journal Article] The Prediction of the Relative Importance of Cyp3a/P-Glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model.2016

    • Author(s)
      Takano J, Maeda K, Bolger MB, Sugiyama Y.
    • Journal Title

      Drug Metab Dispos

      Volume: 44 Pages: 1808-1818

    • DOI

      10.1124/dmd.116.070011

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 to Develop Sensitive Fluorescence-Based Oatp1B1 Inhibition Assays.2016

    • Author(s)
      Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y.
    • Journal Title

      Mol Pharm

      Volume: 13 Pages: 438-448

    • DOI

      10.1021/acs.molpharmaceut.5b00664

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs.2016

    • Author(s)
      Hayakawa Y, Kawada M, Nishikawa H, Ochiya T, Saya H, Seimiya H, Yao Y, Hayashi M, Kai C, Matsuda A, Naoe T, Ohtsu A, Okazaki T, Saji H, Sata M, Sugimura H, Sugiyama Y, Toi M, Irimura T
    • Journal Title

      Cancer Sci.

      Volume: 107(2) Pages: 189-202

    • DOI

      10.1111/cas.12857

    • NAID

      120006333896

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670023, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25293011, KAKENHI-PROJECT-25293184, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-15K06888, KAKENHI-PROJECT-16K15551, KAKENHI-PROJECT-26290054
  • [Journal Article] Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments.2016

    • Author(s)
      Kanamitsu K, Arakawa R, Sugiyama Y, Suhara T, Kusuhara H.
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 31 Pages: 395-404

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method.2016

    • Author(s)
      Yoshikado T, Yoshida K, Kotani N, Nakada T, Asaumi R, Toshimoto K. Maeda K, Kusuhara H, Sugiyama Y.
    • Journal Title

      Clin Pharmacol Ther

      Volume: 100 Pages: 513-523

    • DOI

      10.1002/cpt.391

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] An Assessment of the Oral Bioavailability of Three Ca-Channel Blockers Using a Cassette-Microdose Study: A New Strategy for Streamlining Oral Drug Development.2015

    • Author(s)
      Yamashita M, Kataoka Y, Suzaki H, Imai T, Morimoto K, Ohashi A, Inano K, Togashi K, Mutaguchi K, Sugiyama Y.
    • Journal Title

      J Pharm Sci

      Volume: 104 Pages: 3154-3161

    • DOI

      10.1002/jps.24499

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Involvement of Organic Cation Transporters in the Clearance and Milk Secretion of Thiamine in Mice.2015

    • Author(s)
      Kato K, Moriyama C, Ito N, Zhang X, Hachiuma K, Hagima N, Iwata K, Yamaguchi J, Maeda K, Ito K, Suzuki H, Sugiyama Y, Kusuhara H.
    • Journal Title

      Pharm Res

      Volume: 32 Pages: 2192-2204

    • DOI

      10.1007/s11095-014-1608-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] A clinical pharmacokinetic microdosing study of docetaxel with Japanese patients with cancer.2015

    • Author(s)
      Fujita K, Yoshino E, Kawara K, Maeda K, Kusuhara H, Sugiyama Y, Yokoyama T, Kaneta T, Ishida H, Sasaki Y.
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 76 Pages: 793-801

    • DOI

      10.1007/s00280-015-2844-2

    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C] Metformin in Mouse.2015

    • Author(s)
      Shingaki T, Hume WE, Takashima T, Katayama Y, Okauchi T, Hayashinaka E, Wada Y, Cui Y, Kusuhara H, Sugiyama Y, Watanabe Y.
    • Journal Title

      Pharm Res

      Volume: 32 Pages: 2538-2547

    • DOI

      10.1007/s11095-015-1642-1

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] The synthesis of [18F] pitavastatin as a tracer for hOATP using the Suzuki coupling.2015

    • Author(s)
      Y. Yagi, H. Kimura, K. Arimitsu, M. Ono, K. Maeda, H. Kusuhara, T. Kajimoto, Y. Sugiyama, H. Saji
    • Journal Title

      Org Biomol Chem

      Volume: 13 Pages: 1113-1121

    • DOI

      10.1039/c4ob01953a

    • NAID

      120005619803

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26460022, KAKENHI-PROJECT-24229002
  • [Journal Article] Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug Interactions.2015

    • Author(s)
      Izumi S, Nozaki Y, Maeda K, Komori T, Takenaka O, Kusuhara H, Sugiyama Y.
    • Journal Title

      Drug Metab Dispos

      Volume: 43 Pages: 235-247

    • DOI

      10.1124/dmd.114.059105

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Effects of Cremophor El on the Absorption of Orally Administered Saquinavir and Fexofenadine in Healthy Subjects.2015

    • Author(s)
      Tomaru A, Takeda-Morishita M, Maeda K, Banba H, Takayama K, Kumagai Y, Kusuhara H, Sugiyama Y
    • Journal Title

      Drug Metab Pharmacokinet Jun

      Volume: 印刷中 Pages: 221-226

    • DOI

      10.1016/j.dmpk.2015.01.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24689009, KAKENHI-PROJECT-24229002
  • [Journal Article] Use of a Physiologically Based Pharmacokinetic Model for Quantitative Prediction of Drug-Drug Interactions Via Cyp3a4 and Estimation of the Intestinal Availability of Cyp3a4 Substrates.2015

    • Author(s)
      Y. Mano, Y. Sugiyama, K. Ito
    • Journal Title

      J Pharm Sci

      Volume: 104 Pages: 3183-3193

    • DOI

      10.1002/jps.24495

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26460209, KAKENHI-PROJECT-24229002
  • [Journal Article] Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration.2015

    • Author(s)
      Liu H, Yu N, Lu S, Ito S, Zhang X, Prasad B, He E, Lu X, Li Y, Wang F, Xu H, An G, Unadkat JD, Kusuhara H, Sugiyama Y, Sahi J.
    • Journal Title

      Drug Metab Dispos

      Volume: 43 Pages: 1008-1018

    • DOI

      10.1124/dmd.115.064170

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293032, KAKENHI-PROJECT-24229002
  • [Journal Article] Quantitative Analysis of the Abcg2 C.421c>a Polymorphism Effect on in Vivo Transport Activity of Breast Cancer Resistance Protein (Bcrp) Using an Intestinal Absorption Model.2015

    • Author(s)
      Tanaka Y, Kitamura Y, Maeda K, Sugiyama Y
    • Journal Title

      J Pharm Sci

      Volume: 印刷中 Pages: 3093-3048

    • DOI

      10.1002/jps.24366

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24689009, KAKENHI-PROJECT-24229002
  • [Journal Article] Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans.2014

    • Author(s)
      Maeda K, Tian Y, Fujita T, Ikeda Y, Kumagai Y, Kondo T, Tanabe K, Nakayama H, Horita S, Kusuhara H, Sugiyama Y.
    • Journal Title

      Eur J Pharm Sci

      Volume: - Pages: 94-103

    • DOI

      10.1016/j.ejps.2014.04.004

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23590646, KAKENHI-PROJECT-24229002
  • [Journal Article] 6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects.2014

    • Author(s)
      Imamura Y, Tsuruya Y, Damme K, Heer D, Kumagai Y, Maeda K, Murayama N, Okudaira N, Kurihara A, Izumi T, Sugiyama Y, Kusuhara H.
    • Journal Title

      Drug Metab Dispos

      Volume: 42 Pages: 685-694

    • DOI

      10.1124/dmd.113.055475

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659071
  • [Journal Article] Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins.2014

    • Author(s)
      Kato K, Mori H, Kito T, Yokochi M, Ito S, Inoue K, Yonezawa A, Katsura T, Kumagai Y, Yuasa H, Moriyama Y, Inui K, Kusuhara H, Sugiyama Y.
    • Journal Title

      Pharm Res.

      Volume: 31 Pages: 136-147

    • DOI

      10.1007/s11095-013-1144-y

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23390138, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-25670074
  • [Journal Article] A Proposal of a Pharmacokinetic/pharmacodynamic (PK/PD) Index Map for Selecting an Optimal PK/PD Index from Conventional Indices (AUC/MIC, C<sub>max</sub>/MIC, and TAM) for Antibiotics2014

    • Author(s)
      Kitamura Y, Yoshida K, Kusama M and Sugiyama Y.
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 29 Issue: 6 Pages: 455-462

    • DOI

      10.2133/dmpk.dmpk-14-rg-013

      10.2133/dmpk.DMPK-14-RG-013

    • NAID

      130004933551

    • ISSN
      1347-4367, 1880-0920
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Quantitative investigation of the brain-to-cerebrospinal fluid unbound drug concentration ratio under steady-state conditions in rats using a pharmacokinetic model and scaling factors for active efflux transporters.2014

    • Author(s)
      Kodaira H, Kusuhara H, Fuse E, Ushiki J, Sugiyama Y.
    • Journal Title

      Drug Metab Dispos.

      Volume: 42 Pages: 983-9

    • DOI

      10.1124/dmd.113.056606

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002
  • [Journal Article] Differential Roles of Ubiquitination in the Degradation Mechanism of Cell Surface-resident BSEP and MRP2.2014

    • Author(s)
      Aida K, Hayashi H, Inamura K, Mizuno T, Sugiyama Y
    • Journal Title

      Mol Pharmacol

      Volume: Vol85, No.3 Pages: 482-491

    • DOI

      10.1124/mol.113.091090

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J11195, KAKENHI-PROJECT-24229002
  • [Journal Article] Prediction of inter-individual variability in the pharmacokinetics of CYP2C19 substrates in humans.2014

    • Author(s)
      Chiba K, Shimizu K, Kato M, Nishibayashi T, Terada K, Izumo N and Sugiyama Y.
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 29 Pages: 379-86

    • NAID

      130004463402

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam (CYP3A4), fexofenadine (p-glycoprotein), and pravastatin (OATP1B1) as probe drugs.2013

    • Author(s)
      Ieiri I, Tsunemitsu S, Maeda K, Ando Y, Izumi N, Kimura M, Yamane N, Okuzono T, Morishita M, Kotani N, Kanda E, Deguchi M, Matsuguma K, Matsuki S, Hirota T, Irie S, Kusuhara H, Sugiyama Y.
    • Journal Title

      J Clin Pharmacol

      Volume: 53 Pages: 1-16

    • DOI

      10.1002/jcph.62

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24689009
  • [Journal Article] Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption.2013

    • Author(s)
      Shitara Y, Maeda K, Ikejiri K, Yoshida K, Horie T, Sugiyama Y
    • Journal Title

      Biopharm Drug Dispos

      Volume: 34 Pages: 45-78

    • DOI

      10.1002/bdd.1823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J09907, KAKENHI-PROJECT-24229002, KAKENHI-PLANNED-23136101
  • [Journal Article] DNA methylation and histone modification profiles of mouse organic anion transporting polypeptides.2013

    • Author(s)
      Imai S.
    • Journal Title

      Drug Metab Dispos

      Volume: 41 Pages: 72-78

    • DOI

      10.1124/dmd.112.047969

    • NAID

      130004639789

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002
  • [Journal Article] Investigation of the effect of active efflux at the blood-brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system.2013

    • Author(s)
      Miyajima M, Kusuhara H, Takahashi K, Takashima T, Hosoya T, Watanabe Y, Sugiyama Y.
    • Journal Title

      J Pharm Sci

      Volume: 102 Pages: 3309-3319

    • DOI

      10.1002/jps.23600

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002
  • [Journal Article] Hepatic and intestinal drug transporters: prediction of pharmacokinetic effects caused by drug-drug interactions and genetic polymorphisms.2013

    • Author(s)
      Yoshida K, Maeda K and Sugiyama Y
    • Journal Title

      Annu Rev Pharmacol Toxicol

      Volume: 53 Pages: 581-612

    • DOI

      10.1146/annurev-pharmtox-011112-140309

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J09907, KAKENHI-PROJECT-24229002, KAKENHI-PLANNED-23136101
  • [Journal Article] Effect of the fluoroquinolone antibacterial agent DX-619 on the apparent formation and renal clearances of 6beta-hydroxycortisol, an endogenous probe for CYP3A4 inhibition, in healthy subjects.2013

    • Author(s)
      Imamura Y, Murayama N, Okudaira N, Kurihara A, Inoue K, Yuasa H, Izumi T, Kusuhara H and Sugiyama Y.
    • Journal Title

      Pharm Res

      Volume: 30 Pages: 447-457

    • DOI

      10.1007/s11095-012-0890-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Effect of coadministration of single and multiple doses of rifampicin on the pharmacokinetics of fexofenadine enantiomers in healthy subjects.2013

    • Author(s)
      Kusuhara H
    • Journal Title

      Drug Metab Dispos

      Volume: 41 Pages: 206-13

    • DOI

      10.1124/dmd.112.048330

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002, KAKENHI-PLANNED-23136101
  • [Journal Article] The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo.2013

    • Author(s)
      Hume WE, Shingaki T, Takashima T, Hashizume Y, Okauchi T, Katayama Y, Hayashinaka E, Wada Y, Kusuhara H, Sugiyama Y and Watanabe Y.
    • Journal Title

      Bioorg Med Chem

      Volume: 21 Pages: 7584-7590

    • DOI

      10.1016/j.bmc.2013.10.041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Substrate-dependent inhibition of organic anion transporting polypeptide 1B1: comparative analysis with prototypical probe substrates estradiol-17beta-glucuronide, estrone-3-sulfate, and sulfobromophthalein.2013

    • Author(s)
      Izumi S, Nozaki Y, Komori T, Maeda K, Takenaka O, Kusano K, Yoshimura T, Kusuhara H and Sugiyama Y.
    • Journal Title

      Drug Metab Dispos

      Volume: 41 Pages: 1859-1866

    • DOI

      10.1124/dmd.113.052290

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Evaluation of Bcrp Function in Hepatobiliary and Renal Excretion using PET with [11C]SC-628072013

    • Author(s)
      Takashima T, Wu C, Takashima-Hirano M, Katayama Y, Wada Y, Suzuki M, Kusuhara H, Sugiyama Y and Watanabe Y.
    • Journal Title

      J Nucl Med.

      Volume: 54 Pages: 267-276

    • DOI

      10.2967/jnumed.112.110254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-25242070, KAKENHI-PLANNED-23136101
  • [Journal Article] Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes.2013

    • Author(s)
      Kudo T, Hisaka A, Sugiyama Y, Ito K.
    • Journal Title

      Drug Metab Dispos

      Volume: 41 Pages: 362-371

    • DOI

      10.1124/dmd.112.049460

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590204, KAKENHI-PROJECT-24229002
  • [Journal Article] Investigation of the effect of the uneven distribution of CYP3A4 and P-glycoprotein in the intestine on the barrier function against xenobiotics: a simulation study.2013

    • Author(s)
      Watanabe T, Maeda K, Nakai C and Sugiyama Y.
    • Journal Title

      J Pharm Sci

      Volume: 102 Pages: 3196-3204

    • DOI

      10.1002/jps.23623

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24689009
  • [Journal Article] Transporter biology in drug approval: regulatory aspects.2013

    • Author(s)
      Maeda K and Sugiyama Y.
    • Journal Title

      Mol Aspects Med

      Volume: 34 Pages: 711-718

    • DOI

      10.1016/j.mam.2012.10.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Cost-effectiveness analysis of microdose clinical trials in drug development.2013

    • Author(s)
      Yamane N, Igarashi A, Kusama M, Maeda K, Ikeda T and Sugiyama Y.
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 28 Pages: 187-195

    • NAID

      130004463302

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Direct and rapid genotyping of SLCO1B1 388A>G and 521T>C in human blood specimens using the SmartAmp-2 method.2013

    • Author(s)
      Yoshida K, Takano J, Ishizu Y, Lezhava A, Ieiri I, Maeda K, Hayashizaki Y and Sugiyama Y.
    • Journal Title

      AAPS J

      Volume: 15 Pages: 618-622

    • DOI

      10.1208/s12248-013-9471-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Drug interacting with organic anion transporter-1 affect uptake of Tc-99 m-mercaptoacetyltiglycine2013

    • Author(s)
      Takahara N, Saga T, Inubushi M, Kusuhara H, Seki C, Ito S, Oyama N, Yokoyama O, Sugiyama Y, Fujibayashi Y.
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 40 Pages: 643-650

    • DOI

      10.1016/j.nucmedbio.2013.03.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390239, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659140, KAKENHI-PROJECT-24659559
  • [Journal Article] Microdose pharmacogenetic study of (1)(4)C-tolbutamide in healthy subjects with accelerator mass spectrometry to examine the effects of CYP2C9 *3 on its pharmacokinetics and metabolism.2013

    • Author(s)
      Ikeda T, Aoyama S, Tozuka Z, Nozawa K, Hamabe Y, Matsui T, Kainuma M, Hasegawa S, Maeda K and Sugiyama Y.
    • Journal Title

      Eur J Pharm Sci

      Volume: 49 Pages: 642-648

    • DOI

      10.1016/j.ejps.2013.05.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203.2013

    • Author(s)
      Toyoshima J, Kusuhara H, Wempe MF, Endou H, Sugiyama Y.
    • Journal Title

      J Pharm Sci

      Volume: 102 Pages: 3228-3238

    • DOI

      10.1002/jps.23601

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002
  • [Journal Article] Relationship between the urinary excretion mechanisms of drugs and their physicochemical properties.2013

    • Author(s)
      Ito S, Ando H, Ose A, Kitamura Y, Ando T, Kusuhara H, Sugiyama Y.
    • Journal Title

      J Pharm Sci

      Volume: 102 Pages: 3294-3301

    • DOI

      10.1002/jps.23599

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002
  • [Journal Article] Studies on the intestinal absorption characteristics of sulfasalazine, a breast cancer resistance protein (BCRP) substrate.2013

    • Author(s)
      Tomaru A, Morimoto N, Morishita M, Takayama K, Fujita T, Maeda K, Kusuhara H and Sugiyama Y.
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 28 Pages: 71-74

    • NAID

      130004463289

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Epigenetic Regulation of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines.2013

    • Author(s)
      Imai S, Kikuchi R, Tsuruya Y, Naoi S, Nishida S, Kusuhara H, Sugiyama Y.
    • Journal Title

      Pharm Res

      Volume: 30 Pages: 2880-2890

    • DOI

      10.1007/s11095-013-1117-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J10600, KAKENHI-PROJECT-13J08293, KAKENHI-PROJECT-24229002
  • [Journal Article] Factors associated with spontaneous reporting of adverse drug reactions in Japan.2013

    • Author(s)
      Yamada T, et al.
    • Journal Title

      Pharmacoepidemiol Drug Saf

      Volume: 22 Pages: 468-476

    • DOI

      10.1002/pds.3378

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590100, KAKENHI-PROJECT-21790109, KAKENHI-PROJECT-24229002
  • [Journal Article] Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography (PET) tracer, [11C]dehydropravastatin, in rats2013

    • Author(s)
      Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui Y, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
    • Journal Title

      J. Pharmacol. Exp. Ther.

      Volume: 347 Pages: 193-202

    • DOI

      10.1124/jpet.113.206425

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659574, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
  • [Journal Article] Microdosing clinical study: pharmacokinetic, pharmacogenomic (SLCO2B1), and interaction (grapefruit Juice) profiles of celiprolol following the oral microdose and therapeutic dose.2012

    • Author(s)
      Ieiri I, Doi Y, Maeda K, Sasaki T, Kimura M, Hirota T, Chiyoda T, Miyagawa M, Irie S, Iwasaki K, Sugiyama Y.
    • Journal Title

      J Clin Pharmacol

      Volume: 52 Pages: 1078-89

    • DOI

      10.1177/0091270011408612

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] PET imaging-based evaluation of hepatobiliary transport in humans with (15R)-11C-TIC-Me.2012

    • Author(s)
      Tadayuki Takashima, Satoshi Kitamura, Yasuhiro Wada, Masaaki Tanaka, Yoshihito Shigihara, Hideki Ishii, Ryosuke Ijuin, Susumu Shiomi, Takahiro Nakae, Yumiko Watanabe, Yilong Cui, Hisashi Doi, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
    • Journal Title

      J Nucl Med

      Volume: 53 Pages: 741-748

    • DOI

      10.2967/jnumed.111.098681

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790121, KAKENHI-PROJECT-23300241, KAKENHI-PROJECT-24229002
  • [Journal Article] Prediction of nonlinear intestinal absorption of CYP3A4 and P-glycoprotein substrates from their in vitro Km values.2012

    • Author(s)
      Tachibana T, Kato M, Sugiyama Y.
    • Journal Title

      Pharm Res

      Volume: 29 Pages: 651-68

    • DOI

      10.1007/s11095-011-0579-2

    • NAID

      130004639845

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] 薬物の効果・副作用におよぼす肝トランスポーターの役割-薬物間相互作用、遺伝子多型を中心に2012

    • Author(s)
      杉山雄一
    • Journal Title

      薬理と治療

      Volume: 33 Pages: 939-945

    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- and OATP1B3-mediated uptake.2012

    • Author(s)
      Shitara Y, Takeuchi K, Nagamatsu Y, Wada S, Sugiyama Y, Horie T.
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 27 Pages: 368-78

    • NAID

      130004463264

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Association of multidrug resistance-associated protein 2 single nucleotide polymorphism rs12762549 with the basal plasma levels of phase II metabolites of isoflavonoids in healthy Japanese individuals.2012

    • Author(s)
      Kato K, et al
    • Journal Title

      Pharmacogenet Genomics

      Volume: 22 Pages: 344-354

    • DOI

      10.1097/fpc.0b013e3283517012

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002
  • [Journal Article] Synthesis of [(11)C]dehydropravastatin, a PET probe potentially useful for studying OATP1B1 and MRP2 transporters in the liver.2012

    • Author(s)
      Ryosuke Ijuin, Tadayuki Takashima, Yasuyoshi Watanabe, Yuichi Sugiyama and Masaaki Suzuki
    • Journal Title

      Bioorg Med Chem

      Volume: 20 Pages: 3703-3709

    • DOI

      10.1016/j.bmc.2012.04.051

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790121, KAKENHI-PROJECT-24229002
  • [Journal Article] Whole-body distribution and radiation dosimetry of [11C]telmisartan as a biomarker for hepatic organic anion transporting polypeptide (OATP) 1B3.2012

    • Author(s)
      Shimizu K, Takashima T, Yamane T, Sasaki M, Kageyama H, Hashizume Y, Maeda K, Sugiyama Y, Watanabe Y, Senda M.
    • Journal Title

      Nucl Med Biol

      Volume: 39 Pages: 847-53

    • DOI

      10.1016/j.nucmedbio.2012.01.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure.2012

    • Author(s)
      Endo S, Fukahori A, Tokuhiro S, Shinagawa A, Walker J, Yoshihara K, Ishizuka H, Ieiri I, Sugiyama Y.
    • Journal Title

      J Hum Genet

      Volume: 57 Pages: 531-44

    • DOI

      10.1038/jhg.2012.63

    • NAID

      10031056697

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.2012

    • Author(s)
      Ito S、Kusuhara H、Yokochi M、ToyoshimaJ、Inoue K、Yuasa H、Sugiyama Y
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 340巻 Pages: 393-403

    • DOI

      10.1124/jpet.111.184986

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008, KAKENHI-PROJECT-24229002
  • [Journal Article] Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP.2012

    • Author(s)
      Kusuhara H, et al
    • Journal Title

      British Journal of Pharmacology

      Volume: (In press) Pages: 1793-1803

    • DOI

      10.1111/j.1476-5381.2012.01887.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-23590206, KAKENHI-PROJECT-24229002
  • [Journal Article] Regulation of Tissue-Specific Expression of Renal Organic Anion Transporters by Hepatocyte Nuclear Factor 1 alpha/beta and DNA Methylation2012

    • Author(s)
      Jin L、Kikuchi R、Saji T、Kusuhara H、Sugiyama Y
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 340巻 Pages: 648-655

    • DOI

      10.1124/jpet.111.187161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Dynamic analysis of GI absorption and hepatic distribution processes of telmisartan in rats using positron emission tomography.2012

    • Author(s)
      Kataoka M, Takashima T, Shingaki T, Hashidzume Y, Katayama Y, Wada Y, Oh H, Masaoka Y, Sakuma S, Sugiyama Y, Yamashita S, Watanabe Y.
    • Journal Title

      Pharm Res

      Volume: 29 Pages: 2419-31

    • DOI

      10.1007/s11095-012-0768-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Pharmacogenomic/pharmacokinetic assessment of a four-probe cocktail for CYPs and OATPs following oral microdosing.2012

    • Author(s)
      Ieiri I, Fukae M, Maeda K, Ando Y, Kimura M, Hirota T, Nakamura T, Iwasaki K, Matsuki S, Matsuguma K, Kanda E, Deguchi M, Irie S, Sugiyama Y.
    • Journal Title

      Int J Clin Pharmacol Ther

      Volume: 50 Pages: 689-700

    • DOI

      10.5414/cp201763

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Prediction of the degree oftransporter-mediated drug-drug interactions involving OATP substrates based on in vitro inhibition studies、2012

    • Author(s)
      Yoshida K、Maeda K、Sugiyama Y
    • Journal Title

      Clin Pharmacol Ther

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes.2012

    • Author(s)
      Nakakariya M, Ono M, Amano N, Moriwaki T, Maeda K, Sugiyama Y.
    • Journal Title

      Drug Metab Dispos

      Volume: 40 Pages: 602-9

    • DOI

      10.1124/dmd.111.042101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Journal Article] Prediction of the degree of transporter-mediated drug-drug interactions involving OATP substrates based on in vitro inhibition studies2012

    • Author(s)
      Kenta Yoshida, Kazuya Maeda, Yuichi Sugiyama
    • Journal Title

      Clin Pharmacol Ther

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] 薬物の効果・副作用におよぼす肝トランスポーターの役割2012

    • Author(s)
      杉山雄一
    • Journal Title

      薬物間相互作用、遺伝子多型を中心に、薬理と治療

      Volume: 33巻 Pages: 939-945

    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving OAT3 in humans by in vitro uptake experiments.2011

    • Author(s)
      Watanabe T, Kusuhara H, Watanabe T, Debori Y, Maeda K, Kondo T, Nakayama H, Horita S, Ogilvie BW, Parkinson A, Hu Z, Sugiyama Y
    • Journal Title

      Drug Metab Dispos in press

    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Organic Anion Transporter 3 Mediates the Efflux Transport of an Amphipathic Organic Anion, Dehydroepiandrosterone Sulfate, across the Blood-Brain Barrier in Mice2011

    • Author(s)
      Miyajima M、Kusuhara H、Fujishima M、Adachi Y、Sugiyama Y
    • Journal Title

      Drug Metab Dispos

      Volume: 39巻 Pages: 814-819

    • DOI

      10.1124/dmd.110.036863

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Prediction of fluoroquinolone-induced elevation in serum creatinine levels : a case of drug-endogenous substance interaction involving the inhibition of renal secretion.2011

    • Author(s)
      Imamura Y, Murayama N, Okudaira N, Kurihara A, Okazaki O, Izumi T, Inoue K, Yuasa H, Kusuhara H, Sugiyama Y.
    • Journal Title

      Clin Pharmacol Ther

      Volume: 89 Pages: 81-88

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes2011

    • Author(s)
      Kotani N、Maeda K、Watanabe T、HiramatsuM、Gong L-K、Bi Y-A、Takezawa T、Kusuhara H、Sugiyama Y
    • Journal Title

      Drug Metab Dispos

      Volume: 39巻 Pages: 1503-1510

    • DOI

      10.1124/dmd.111.038968

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving OAT3 in humans by in vitro uptake experiments.2011

    • Author(s)
      Watanabe T, Kusuhara H, Watanabe T, Debori Y, Maeda K, Kondo T, Nakayama H, Horita S, Ogilvie BW, Parkinson A, Hu Z, Sugiyama Y.
    • Journal Title

      Drug Metab Dispos

      Volume: In press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Quantitative evaluation of the impact of active efflux byp-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate2011

    • Author(s)
      Kodaira H、Kusuhara H、Fujita T、Ushiki J、Fuse E、Sugiyama Y
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 339巻 Pages: 935-944

    • DOI

      10.1124/jpet.111.180398

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans byIn Vitro Uptake Experiments2011

    • Author(s)
      Watanabe T、Kusuhara H、Watanabe T、Debori Y、Maeda K、Kondo T、NakayamaH、Horita S、Ogilvie BW、Parkinson A、Hu Z、Sugiyama Y
    • Journal Title

      Drug Metab Dispos

      Volume: 39巻 Pages: 1031-1038

    • DOI

      10.1124/dmd.110.036129

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Prediction of fluoroquinolone-induced elevation in serum creatinine levels : a caseof drug-endogenous substance interaction involving the inhibition of renal secretion2011

    • Author(s)
      Imamura Y、Murayama N、Okudaira N、Kurihara A、Okazaki O、Izumi T、Inoue K、Yuasa H、Kusuhara H、Sugiyama Y
    • Journal Title

      Clin Pharmacol Ther

      Volume: 89巻 Pages: 81-88

    • DOI

      10.1038/clpt.2010.232

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters2010

    • Author(s)
      Kusuhara H、Sugiyama Y
    • Journal Title

      Drug Metab Rev

      Volume: 42巻 Pages: 539-550

    • DOI

      10.1124/jpet.109.162321

    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] DNA Methylation Profiles of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines2010

    • Author(s)
      Ichihara S, Kikuchi R, Kusuhara H, Imai S, Maeda K, Sugiyama Y.
    • Journal Title

      Pharm Res 27(3)

      Pages: 510-516

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier2010

    • Author(s)
      Ose A、Kusuhara H、Endo C、Tohyama K、Miyajima M、Kitamura S、Sugiyama Y
    • Journal Title

      Drug Metab Dispos

      Volume: 38巻 Pages: 168-76

    • DOI

      10.1124/jpet.109.156943

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3(Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse2010

    • Author(s)
      Kitamura Y、Kusuhara H、Sugiyama Y
    • Journal Title

      Pharm Res

      Volume: 27巻 Pages: 665-672

    • DOI

      10.1007/s11095-009-0047-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse2010

    • Author(s)
      Kitamura Y, Kusuhara H, Sugiyama Y.
    • Journal Title

      Pharm Res 27(4)

      Pages: 665-672

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans.2010

    • Author(s)
      Watanabe T, Kusuhara H, Sugiyama Y.
    • Journal Title

      J Pharmacokinet Pharmacodyn

      Volume: 37 Pages: 575-590

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] The use of hepatocytes to investigate drug uptake transporters2010

    • Author(s)
      Maeda K、Sugiyama Y
    • Journal Title

      Methods Mol Biol

      Volume: 640巻 Pages: 327-353

    • DOI

      10.1007/978-1-60761-688-7_18

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Direct and rapid genotyping of glutathione-S-transferase M1 and T1 from human blood specimens using the SmartAmp2 method2010

    • Author(s)
      Okada R、Ishizu Y、Endo R、Lezhava A、Ieiri I、Kusuhara H、Sugiyama Y、Hayashizaki Y
    • Journal Title

      Drug Metab Dispos

      Volume: 38巻 Pages: 1636-1639

    • DOI

      10.1124/jpet.110.170092

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Kinetic Analysis of the Cooperation of P-glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone2010

    • Author(s)
      Hiroshi Kodaira, Hiroyuki Kusuhara, Junko Ushiki, Eiichi Fuse, Yuichi Sugiyama
    • Journal Title

      J Pharmacol Exp Ther (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Functional Characterization of Multidrug Resistance-Associated Proten 3 (Mrp3/Abcc3) in the Basolateral Efflux of Glucuronide Conjugates in the Mouse Small Intestine2010

    • Author(s)
      Yoshiaki Kitamura, Hiroyuki Kusuhara, Yuichi Sugiyama
    • Journal Title

      J Pharmacol Exp Ther 332

      Pages: 659-666

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Predicting drug-drug interactions involving the inhibition of intestinal CYP3A4 and P-glycoprotein.2010

    • Author(s)
      Tachibana T, Kato M, Takano J, Sugiyama Y
    • Journal Title

      Curr Drug Metab

      Volume: 11 Pages: 762-777

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters.2010

    • Author(s)
      Kusuhara H, Sugiyama Y
    • Journal Title

      Drug Metab Rev (In press)

    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] The use of hepatocytes to investigate drug uptake transporters.2010

    • Author(s)
      Maeda K., Sugiyama Y
    • Journal Title

      Methods Mol Biol

      Volume: 640 Pages: 327-353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Functional Characterization of Multidrug Resistance-Associated Protein 3(Mrp3/Abcc3) in the Basolateral Efflux of Glucuronide Conjugates in the Mouse Small Intestine2010

    • Author(s)
      Kitamura Y、Kusuhara H、Sugiyama Y
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 332巻 Pages: 659-666

    • DOI

      10.1007/s11095-010-0064-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Positron emission tomography studies using (15R)-16-m-[11C]tolyl-17,18,19,20-tetra norisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.2010

    • Author(s)
      Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
    • Journal Title

      J Pharmacol Exp Ther 335

      Pages: 314-323

    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Direct and rapid genotyping of glutathione-S-transferase M1 and T1 from human blood specimens using the SmartAmp2 method.2010

    • Author(s)
      Okada R, Ishizu Y, Endo R, Lezhava A, Ieiri I, Kusuhara H, Sugiyama Y, Hayashizaki Y.
    • Journal Title

      Drug Metab Dispos

      Volume: 38 Pages: 1636-1639

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Positron emission tomography studies using(15R)-16-m-[11C]tolyl-17,18,19,20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.2010

    • Author(s)
      Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 335 Pages: 314-323

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.2010

    • Author(s)
      Ose A, Kusuhara H, Endo C, Tohyama K, Miyajima M, Kitamura S, Sugiyama Y.
    • Journal Title

      Drug Metab Dispos 38(1)

      Pages: 168-176

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Kinetic Analysis of the Cooperation of P-glycoprotein(P-gp/Abcb1) and Breast Cancer Resistance Protein(Bcrp/Abcg2) in Limiting the Brainand Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone2010

    • Author(s)
      Kodaira H、Kusuhara H、Ushiki J、Fuse E、Sugiyama Y
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 333巻 Pages: 788-796

    • DOI

      10.1124/dmd.110.034652

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Predicting drug-drug interactions involving the inhibition of intestinal CYP3A4 and P-glycoprotein2010

    • Author(s)
      Tachibana T、Kato M、Takano J、SugiyamaY
    • Journal Title

      Curr Drug Metab

      Volume: 11巻 Pages: 762-777

    • DOI

      10.2174/138920010794328922

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Positron emission tomography studies using(15R)-16-m-[ 11C] tolyl-17, 18, 19, 20-tetranor isocarbacyclin methyl ester for theevaluation of hepatobiliary transport2010

    • Author(s)
      Watanabe T、Kusuhara H、Sugiyama Y
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 37巻 Pages: 314-323

    • DOI

      10.1007/s10928-010-9176-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATPIBI/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.2009

    • Author(s)
      Hirouchi M, Kusuhara H, Onuki R, Ogilvie BW, Parkinson A, Sugiyama Y.
    • Journal Title

      Drug Metab Dispos 37

      Pages: 2103-2111

    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Prediction of the effects of genetic polymorphism on the pharmacokinetics of CYP2C9 substrates from in vitro data2009

    • Author(s)
      Kusama M、Maeda K、Chiba K、Aoyama A、Sugiyama Y
    • Journal Title

      Pharm Res

      Volume: 26巻 Pages: 822-35

    • DOI

      10.1007/s11095-008-9781-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008, KAKENHI-PROJECT-21790109
  • [Journal Article] Physiologically Based Pharmacokinetic Modeling to Predict Transporter-mediated Clearance and Distribution of Pravastatin in Humans2009

    • Author(s)
      Watanabe, T., Kusuhara, H., Maeda, K., Shitara, Y. and Sugiyama, Y.
    • Journal Title

      J Pharmacol Exp Ther 328

      Pages: 652-662

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20018006
  • [Journal Article] Construction of triple-transfected cells[ organic anion-transporting polypeptide(OATP) 1B1/multidrugresistance-associated protein(MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP42009

    • Author(s)
      Hirouchi M、Kusuhara H、Onuki R、OgilvieBW、Parkinson A、Sugiyama Y
    • Journal Title

      Drug Metab Dispos

      Volume: 37巻 Pages: 2103-2111

    • DOI

      10.1124/dmd.109.029454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Interindividual pharmacokinetics variability of the alpha(4) beta(1) integrin antagonist, 4-[ 1-[ 3-chloro-4-[ N'-(2-methylphenyl) ureido] phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2-yl] methoxybenzoic acid(D01-4582), inbeagles is associated with albumin2009

    • Author(s)
      Ito T、Takahashi M、Sudo K、Sugiyama Y
    • Journal Title

      J Pharm Sci

      Volume: 98巻 Pages: 1545-1555

    • DOI

      10.1124/jpet.108.148411

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.2009

    • Author(s)
      Matsushima S, Maeda K, Inoue K, Ohta KY, Yuasa H, Kondo T, Nakayama H, Horita S, Kusuhara H, Sugiyama Y
    • Journal Title

      Drug Metab Dispos 37

      Pages: 555-559

    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Limited brain distribution of [3R,4R,5S]-4?acetamido-5-amino 3-(1-ethylpropoxy)-1?cyclohexene-1-carboxylate phosphate (Ro64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/S1c22a8) and multidrug resi stance-associated protein 4 (Mrp4/Abcc4).2009

    • Author(s)
      Ose A, Ito M, Kusuhara H, Yamatsugu K, Kanai M, Shibasaki M, Hosokawa M, Schuetz JD, Sugiyama Y
    • Journal Title

      Drug Metab Dispos 37

      Pages: 315-321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.2009

    • Author(s)
      Hirouchi M, Kusuhara H, Onuki R, Ogilvie BW, Parkinson A, Sugiyama Y.
    • Journal Title

      Drug Metab Dispos 37(10)

      Pages: 2103-2111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Limited brain distribution of[ 3R, 4R, 5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate(Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across theblood-brain barrier mediated by organic anion transporter 3(Oat3/Slc22a8) and multidrug resistance-associated protein 4(Mrp4/Abcc4)2009

    • Author(s)
      Ose A、Ito M、Kusuhara H、Yamatsugu K、Kanai M、Shibasaki M、Hosokawa M、Schuetz JD、Sugiyama Y
    • Journal Title

      Drug Metab Dispos

      Volume: 37巻 Pages: 315-321

    • DOI

      10.1124/dmd.108.024018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] The 8th and 9th transmembrane domains in organic anion trans porting polypeptide (OATP) 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17{beta}-?D-glucuronide.2009

    • Author(s)
      Miyagawa M, Maeda K, Aoyama A, Sugiyama Y
    • Journal Title

      J Pharmacol Exp Ther. (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] The eighth and ninth transmembrane domains in organic anion transporting polypeptide 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17beta-D-glucuronide2009

    • Author(s)
      Miyagawa M、Maeda K、Aoyama A、Sugiyama Y
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 329巻 Pages: 551-557

    • DOI

      10.1124/dmd.109.027193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] 薬物動態関連遺伝子変異と臨床薬理2009

    • Author(s)
      山田哲裕、前田和哉、杉山雄一
    • Journal Title

      治療学 43(3)

      Pages: 28-39

    • NAID

      10018117709

    • Data Source
      KAKENHI-PROJECT-20018006
  • [Journal Article] Interindividual pharmacokinetics variability of the alpha(4) beta(1) integrin antagonist,4-[1-[3-chloro-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2?yl] methoxybenzoic acid (D01-4582), in beagles is associated with albumin genetic polymorphisms.2009

    • Author(s)
      Ito T, Takahashi M, Sudo K, Sugiyama Y.
    • Journal Title

      J Pharm Sci. 98

      Pages: 1545-1555

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] The inhibition of human multidrug and toxin extrusion 1 isinvolved in the drug-drug interaction causedby cimetidine2009

    • Author(s)
      Matsushima S、Maeda K、Inoue K、Ohta KY、Yuasa H、Kondo T、Nakayama H、Horita S、Kusuhara H、Sugiyama Y
    • Journal Title

      Drug Metab Dispos

      Volume: 37巻 Pages: 555-559

    • DOI

      10.1124/dmd.108.023911

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Quantitative population pharmacokinetic analysis of pravastatin using an enterohepatic circulation model combined with pharmacogenomic Information on SLCO1B1 and ABCC2 polymorphisms2009

    • Author(s)
      Ide, T., Sasaki, T., Maeda, K., Higuchi, S., Sugiyama, Y., Ieiri, I.
    • Journal Title

      J Clin Pharmacol 49

      Pages: 1309-1317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20018006
  • [Journal Article] The eighth and ninth transmembrane domains in organic anion transporting polypeptide 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17beta-D-glucuronide.2009

    • Author(s)
      Miyagawa M, Maeda K, Aoyama A, Sugiyama Y.
    • Journal Title

      J Pharmacol Exp Ther 329(2)

      Pages: 551-557

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Prediction of the Effects of Genetic Polymorphism on the Pharmacokinetics of CYP2C9 Substrates from In Vitro Data.2009

    • Author(s)
      Kusama M, Maeda K, Chiba K, Aoyama A, Sugiyama Y.
    • Journal Title

      Pharm Res. 26

      Pages: 822-835

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] The quantitative prediction of CYP-mediated drug interaction by physiologically based pharmacokinetic modeling2008

    • Author(s)
      Kato M、Shitara Y、Sato H、Yoshisue K、Hirano M、Ikeda T、Sugiyama Y
    • Journal Title

      Drug Metab Dispos

      Volume: 25巻 Pages: 1891-1901

    • DOI

      10.1007/s11095-008-9607-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] The quantitative prediction of CYP-mediated drug interaction by physiologically based pharmacokinetic modeling.2008

    • Author(s)
      Kato M, Shitara Y, Sato H, Yoshisue K, Hirano M, Ikeda T, Sugiyama Y
    • Journal Title

      Drug Metab Dispos 25

      Pages: 1891-1901

    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-inding cassette transmembrane transporter subfamily C member 32008

    • Author(s)
      Kobayashi K, Ito K, Takada T, Sugiyama Y, and Suzuki H
    • Journal Title

      Pharmacogenet Genomics 18

      Pages: 823-833

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.2008

    • Author(s)
      Kobayashi K, Ito K, Takada T, Sugiyama Y, Suzuki H.
    • Journal Title

      Pharmacogenet Genomics 18(9)

      Pages: 823-833

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs2008

    • Author(s)
      Maeda K, Sugiyama Y
    • Journal Title

      Drug Metab Pharmacokinet 23

      Pages: 223-235

    • NAID

      10021956066

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20018006
  • [Journal Article] Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans.2008

    • Author(s)
      Kitamura.S, Maeda K, Sugiyama Y
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol. 377

      Pages: 617-628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism2008

    • Author(s)
      Suwannakul S, Ieiri I, Kimura M, Kawabata K, Kusuhara H, Hirota T, Irie S, Sugiyama Y, Higuchi S
    • Journal Title

      J Hum Genet 53

      Pages: 899-904

    • NAID

      10022603002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20018006
  • [Journal Article] ファーマコゲノミクス(総論)2008

    • Author(s)
      前田和哉, 杉山雄一
    • Journal Title

      DNAチップ/マイクロアレイ臨床応用の実際(遺伝子医学MOOK10)

      Pages: 336-349

    • Data Source
      KAKENHI-PROJECT-20018006
  • [Journal Article] Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans2008

    • Author(s)
      Kitamura S、Maeda K、Sugiyama Y
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol

      Volume: 377巻 Pages: 617-628

    • DOI

      10.1007/s00210-008-0312-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Journal Article] ATP-binding cassette subfamily G (ABCG family)2007

    • Author(s)
      Kusuhara H, Sugiyama Y
    • Journal Title

      Pflugers Arch 453 (5)

      Pages: 735-44

    • Data Source
      KAKENHI-PROJECT-17209005
  • [Journal Article] Regional expression and activity of breast cancer resistance protein (ABCG2) in mouse intestine : overlapped distribution with sulfotransferases (SULTs)2007

    • Author(s)
      Enokizono J, Kusuhara H, Sugiyama Y
    • Journal Title

      Drug Metab Dispos (in press)

    • Data Source
      KAKENHI-PROJECT-17209005
  • [Journal Article] Functional involvement of multidrug resistance associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir2007

    • Author(s)
      Imaoka T, Kusuhara H, Adachi M, Schuetz JD, Takeuchi K, Sugiyama Y
    • Journal Title

      Mol Pharmacol 71 (2)

      Pages: 619-27

    • Data Source
      KAKENHI-PROJECT-17209005
  • [Journal Article] Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney2007

    • Author(s)
      Ci L, Kusuhara H, Adachi M, Schuetz JD, Sugiyama Y
    • Journal Title

      Mol Pharmacol (in press)

    • Data Source
      KAKENHI-PROJECT-17209005
  • [Journal Article] Sodium 4-phenylbutyrate induces functional cell surface expression of wild-type and PFIC2-type mutated BSEP2007

    • Author(s)
      Hayashi H, Sugiyama Y
    • Journal Title

      Hepatology (in press)

    • Data Source
      KAKENHI-PROJECT-17209005
  • [Journal Article] Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers.2007

    • Author(s)
      Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y, Suzuki H.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 292(5)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Vectorial transport of enalapril by Oatplal/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers2006

    • Author(s)
      Liu L, Cui Y, Chung AY, Shitara Y, Sugiyama Y, Keppler D, Pang KS
    • Journal Title

      J Pharmacol Exp Ther 318 (1)

      Pages: 395-402

    • Data Source
      KAKENHI-PROJECT-17209005
  • [Journal Article] Efflux mechanism of taurocholate across the rat intestinal basolateral membrane2006

    • Author(s)
      Sakamoto S, Suzuki H, Kusuhara H, Sugiyama Y
    • Journal Title

      Mol Pharm 3 (3)

      Pages: 275-81

    • Data Source
      KAKENHI-PROJECT-17209005
  • [Journal Article] Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep.2006

    • Author(s)
      Mita S, Suzuki H, Akita H, Hayashi H, Onuki R, Hofmann AF, Sugiyama Y
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 290(3)

    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate : A comparison of human BSEP with rat Bsep.2005

    • Author(s)
      Hayashi H., Takada T., Suzuki H., Onuki R., Hofmann AF., Sugiyama Y.
    • Journal Title

      Biochim.Biophys.Acta 1738

      Pages: 54-62

    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Efflux transport systems at the blood-brain barrier and blood-CSF barrier.2005

    • Author(s)
      Kusuhara H, Sugiyama Y
    • Journal Title

      Esteva Foundation Symposium X1 (in press)

    • Data Source
      KAKENHI-PROJECT-15390035
  • [Journal Article] Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein.2005

    • Author(s)
      Matsushima S., Maeda K., Kondo C., Hirano M., Sasaki M., Suzuki H., Sugiyama Y.
    • Journal Title

      J.Pharmacol.Exp.Ther. 314

      Pages: 1059-1067

    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] The quantitative prediction of in vivo enzyme-induction caused by drug exposure from in vitro information on human hepatocytes2005

    • Author(s)
      Kato, M., Chiba, K., Horikawa, M., Sugiyama, Y.
    • Journal Title

      Drug Metab Pharmacokinet 20(4)

      Pages: 236-243

    • NAID

      130004933327

    • Data Source
      KAKENHI-PROJECT-17209005
  • [Journal Article] Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cells.2005

    • Author(s)
      Takada T, Suzuki H, Gotoh Y, Sugiyama Y
    • Journal Title

      Drug Metab Dispos 33(7)

      Pages: 905-909

    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Lack of improvement of oral absorption of ME3277 by prodrug formation is ascribed to the intestinal efflux mediated by breast cancer resistant protein (BCRP/ABCG2).2005

    • Author(s)
      Kondo C., Onuki R., Kusuhara H., Suzuki H., Suzuki M., Okudaira N., Kojima M., Ishiwata K., Jonker JW., Sugiyama Y.
    • Journal Title

      Pharm.Res. 22

      Pages: 613-618

    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer.2005

    • Author(s)
      Yamada T, Arai T, Nagino M, Oda K, Shoda J, Suzuki H, Sugiyama Y, Nimura Y.
    • Journal Title

      Langenbecks Arch Surg 390(5)

      Pages: 421-429

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen.2005

    • Author(s)
      Adachi Y., Suzuki H., Schinkel AH., Sugiyama Y.
    • Journal Title

      Mol.Pharmacol. 67

      Pages: 923-928

    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Characterization of polarized expression of point- or deletion-mutated human BCRP/ABCG2 in LLC-PK1 cells.2005

    • Author(s)
      Takada T., Suzuki H., Sugiyama Y.
    • Journal Title

      Pharm.Res. 22

      Pages: 458-464

    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Efflux transport systems at the blood-brain barrier and blood-CSF barrier.2005

    • Author(s)
      Kusuhara H, Sugiyama Y
    • Journal Title

      Int Congr Ser 1277

      Pages: 111-122

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390035
  • [Journal Article] Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer.2005

    • Author(s)
      Yamada T., Arai T., Nagino M., Oda K., Shoda J., Suzuki H., Sugiyama Y., Nimura Y.
    • Journal Title

      Langenbecks Arch.Surg. 390

      Pages: 421-429

    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11.2005

    • Author(s)
      Hayashi H, Takada T, Suzuki H, Akita H, Sugiyama Y
    • Journal Title

      Hepatology 41(4)

      Pages: 916-924

    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta.2005

    • Author(s)
      Kobayashi D., Ieiri I., Hirota T., Takane H., Maegawa S., Kigawa J., Suzuki H., Nanba E., Oshimura M., Terakawa N., Otsubo K., Mine K., Sugiyama Y.
    • Journal Title

      Drug Metab.Dispos. 33

      Pages: 94-101

    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Efflux transport systems at the blood-brain barrier and blood-CSF barrier.2005

    • Author(s)
      Kusuhara H, Sugiyama Y
    • Journal Title

      the proceedings : Esteva Foundation Symposium X1 (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390035
  • [Journal Article] Active Efflux across the Blood-Brain Barrier : Role of the Solute Carrier Family.2005

    • Author(s)
      Kusuhara H, Sugiyama Y
    • Journal Title

      NeuroRx 2

      Pages: 73-85

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390035
  • [Journal Article] Apical/Basolateral surface expression of drug transporters and its role in vectorial drug transport.2005

    • Author(s)
      Ito K, Suzuki H, Horie T, Sugiyama Y.
    • Journal Title

      Pharm Res 22

      Pages: 1559-1577

    • Data Source
      KAKENHI-PROJECT-17081006
  • [Journal Article] Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene.2005

    • Author(s)
      Hirouchi M, Suzuki H, Sugiyama Y
    • Journal Title

      Pharm Res 22(4)

      Pages: 661-666

    • Data Source
      KAKENHI-PROJECT-17081006
  • [Presentation] Quantitative integration of functional data for human ABC transporters: PET imaging, in vitro functional assays and proteomics.2020

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      ABC2020 - 8th FEBS Special Meeting on ABC Proteins From Multidrug Resistance to Genetic Diseases
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03392
  • [Presentation] プロベネシドと OAT3 基質の薬物間相互作用の個人間変動を加味したモデル構築2020

    • Author(s)
      南 あかり, 梅村 悠人, 大阿久 雅風, 阿部 佐智子, 前田 和哉, 吉門 崇, 岡 美佳子,千葉康司, 杉山 雄一
    • Organizer
      日本薬学会第 140 年会
    • Data Source
      KAKENHI-PROJECT-17K08470
  • [Presentation] Role of Transporters in pharmacokinetics (PK)/ pharmacodynamics (PD)/ toxicodynamics (TD).2019

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      The 4th Lingnan International DMPK Forum
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03392
  • [Presentation] Prediction of the effects of transporter mediated drug-drug interaction and pharmacogenomics on pharmacokinetics (PK) /pharmacodynamics (PD) / toxicodynamics (TD).2019

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      Beijing International Symposium on Drug Metabolism and Pharmacokinetics
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03392
  • [Presentation] PBPK analysis for the prediction of in vivo drug disposition involving enteric and hepatic drug metabolism, uptake and efflux.2019

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      The 12th International ISSX Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03392
  • [Presentation] Quantitative Prediction of the Hepatic Clearance and Complex Drug Interactions Using Extended Clearance Concept and Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Data.2019

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      4th Annual Conference of the Society for the Study of Xenobiotics
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03392
  • [Presentation] 腎有機アニオントランスポータにおけるプロベネシドによる薬物間相互作用を予測するための生理学的薬物速度論に基づく母集団解析モデルの構築2019

    • Author(s)
      山田 莉嵯, 梅村 悠人, 水畑 淳之介, 前田 和哉, 年本 広太, 吉門 崇, 千葉 康司, 杉山 雄一
    • Organizer
      第40回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08470
  • [Presentation] 有機アニオン輸送ポリペプチドの遺伝子多型ごとの個体間変動の推定 ―腸肝循環を考慮した数学モデルによる臨床試験結果からの輸送活性変動の抽出―2019

    • Author(s)
      南 あかり, 千葉 康司, Soo-Jin Kim, 高橋 大貴, 吉門 崇, 杉山 雄一
    • Organizer
      第40回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08470
  • [Presentation] Proposal for predicting drug-drug interaction using PBPK model of coproporphyrin I as an endogeneous OATP1B biomarker.2018

    • Author(s)
      Yoshikado T,Toshimoto K, Maeda K, Kusuhara K, Chiba K, Sugiyama Y.
    • Organizer
      International meeting on 22nd MDO and 33rd JSSX
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08470
  • [Presentation] Construction of a physiologically-based pharmacokinetic model of coproporphyrin I, a putative endogenous probe for hepatic OATP1Bs and MRP2.2018

    • Author(s)
      Yoshikado T, Toshimoto K, Maeda K, Kusuhara H, Chiba K, Sugiyama Y.
    • Organizer
      WCP2018-18th World Congress of Basic and Clinical Pharmacology.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08470
  • [Presentation] Apply a PET Approach to Monitor Hepatic Uptake and Excretory Function.2017

    • Author(s)
      Sugiyama Y.
    • Organizer
      Experimental Biology 2017
    • Place of Presentation
      Chicago, US
    • Year and Date
      2017-04-26
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] PBPK モデルに基づく仮想臨床試験によるタモキシフェン及び活性代謝物の血中曝露及び有効性の前向き予測.2017

    • Author(s)
      中村 利通, 年本 広太, 今村 知世, 谷川原 祐介, 杉山 雄一.
    • Organizer
      日本薬剤学会第32年会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2017-05-12
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] PBPKモデルを用いたパラメータ最適化で得られた薬物阻害定数の妥当性検討.2017

    • Author(s)
      年本 広太, 友田 有加菜, 千葉 康司, 杉山 雄一.
    • Organizer
      日本薬剤学会第32年会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2017-05-11
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 生理学的薬物速度論モデル及びモンテカルロシミュレーションを用いたピタバスタチンの血中濃度推移の個人間変動予測.2017

    • Author(s)
      宮川 麻友子, 年本 広太, 千葉 康司, 杉山 雄一.
    • Organizer
      日本薬剤学会第32年会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2017-05-12
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 接着型ヒト凍結肝細胞の短時間培養法によるOATP基質の取り込み評価:スループットの高い評価法を目指して.2017

    • Author(s)
      森田 清愛, 年本 広太, 杉山 雄一.
    • Organizer
      日本薬剤学会第32年会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2017-05-11
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] The prediction of the relative importance of CYP3A/P-glycoprotein to the nonlinear intestinal absorption of drugs by advanced compartmental absorption and transit model.2017

    • Author(s)
      Maeda K, Takano J, Bolger MB, Sugiyama Y.
    • Organizer
      ASCPT 2017 Annual Meeting
    • Place of Presentation
      Washington Marriott Wardman Park, Washington DC, US
    • Year and Date
      2017-03-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Small-dosing clinical study: pharmacoki- netic, pharmacogeno-mic (SLCO2B1 and ABCG2), and interaction (atorvastatin and grapefruit Juice) profiles of five probes for OATP2B1 and BCRP.2017

    • Author(s)
      Kashihara Y, Ieiri I, Yoshikado T, Maeda K, Fukae M, Kimura M, Hirota T, Matsuki S, Irie S, Izumi N, Kusuhara H, Sugiyama Y.
    • Organizer
      15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
    • Place of Presentation
      国立京都国際会館 (京都府京都市)
    • Year and Date
      2017-09-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 経口投与時におけるBosentanの非線形動態の解析.2017

    • Author(s)
      田中 裕太, 年本 広太, 北村 嘉章, 都丸 充子, 杉山 雄一.
    • Organizer
      日本薬剤学会第32年会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2017-05-11
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] DDIバイオマーカーとしての抱合型・非抱合型ビリルビンPBPKモデルの構築.2017

    • Author(s)
      宮内 正二, Kim Sae Hee, 年本 広太, 楠原 洋之, 杉山 雄一.
    • Organizer
      日本薬剤学会第32年会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2017-05-12
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Is Prediction of Tissue Exposure from In Vitro Data Using PBPK Modeling Possible? Confirmation by PET Imaging to Study the Clinical Disposition of Membrane Transporter Substrates.2017

    • Author(s)
      Sugiyama Y.
    • Organizer
      ITCW 3 Pre-conference 2017
    • Place of Presentation
      Washington, US
    • Year and Date
      2017-03-13
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 肝OATPおよびCYP3Aが関与する薬物間相互作用のPBPKモデル解析.2017

    • Author(s)
      吉門 崇, 前田 和哉, 楠原 洋之, 降旗 謙一, 杉山 雄一.
    • Organizer
      日本薬剤学会第32年会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2017-05-12
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Evaluation of the alteration in BCRP function by c.421C>A polymorphism based on PBPK analysis of rosuvastatin.2016

    • Author(s)
      Futatsugi A, Toshimoto K, Yoshikado T, Kato Y, Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 内在性基質の変動を利用したOATPを介した薬物間相互作用の定量的評価法の開発.2016

    • Author(s)
      楠原 洋之, 吉門 崇, 前田 和哉, 寺島 花野, 中山 丈史, 吉田 美和, 降旗 謙一, 杉山 雄一.
    • Organizer
      日本薬剤学会第31年会
    • Place of Presentation
      長良川国際会議場(岐阜県岐阜市)
    • Year and Date
      2016-05-20
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] トランスポーターの関わるヒト肝クリアランスの予測;アルブミンの関与する肝取り込みをin vitroで評価すべきか?2016

    • Author(s)
      杉山 雄一.
    • Organizer
      第373回CBI学会講演会
    • Place of Presentation
      東京大学山上会館(東京都文京区)
    • Year and Date
      2016-06-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Drug Transporters: Starring roles in New Drug Discovery and Development.2016

    • Author(s)
      Sugiyama Y.
    • Organizer
      The 11th International ISSX Meeting
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2016-06-12
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] IVIVE最近の話題.2016

    • Author(s)
      杉山 雄一.
    • Organizer
      CBI学会第367研究講演会
    • Place of Presentation
      東京大学山上会館(東京都文京区)
    • Year and Date
      2016-12-15
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] In vitro estimation of unbound hepatocyte-to- medium concentration ratios (Kp,uu) of statins considering the membrane potential- dependent passive diffusion.2016

    • Author(s)
      Yoshikado T, Toshimoto K, Nakada T, Ikejiri K, Ogawa K, Hisanaga N, Kusuhara H, Maeda K, Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Drug Transporters: Role in pharmacokinetics (PK) /pharmacodynamics (PD) /toxicodynamics (TD).2016

    • Author(s)
      Sugiyama Y.
    • Organizer
      2016 Fall Annual Convention of Pharmaceutical Society of Korea
    • Place of Presentation
      Seoul Korea
    • Year and Date
      2016-10-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 創薬, 創剤におけるトランスポーター研究の役割.2016

    • Author(s)
      杉山 雄一.
    • Organizer
      第53回薬剤学懇談会研究討論会
    • Place of Presentation
      ルネッサンスリゾートナルト(徳島県鳴門市)
    • Year and Date
      2016-06-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] トランスポーターと薬物代謝酵素が関与する肝消失律速過程の解析.2016

    • Author(s)
      吉門 崇, 降旗 聖子, 寺島 花野, 中山 丈史, 石亀 啓子, 常本 和伸, 前田 和哉, 楠原 洋之, 降旗 謙一, 杉山 雄一.
    • Organizer
      日本動物実験代替法学会第29回大会
    • Place of Presentation
      九州大学百年講堂(福岡県博多区)
    • Year and Date
      2016-11-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Predictability of human serotonin transporter occupancy by SSRI and SNRI using in vitro CNS transporter Ki values and unbound plasma concentration based on literature information.2016

    • Author(s)
      Yahata M, Chiba K, Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Quantitative prediction of hepatic uptake clearance mediated by organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 using relative activity factor-based scaling approach.2016

    • Author(s)
      Izumi S, Nozaki Y, Komori T, Maeda K, Kusuhara H, Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 臨床で認められた非線形薬物動態の原因検討(OATP1B3による肝取込み飽和の可能性).2016

    • Author(s)
      福地 由希菜, 淺海 竜太, 澤田 健史, 戸邉 慈英, 森 貴則, 柿本 啓輔, 河野 健太, 宮内 正二, 年本 広太, 杉山 雄一.
    • Organizer
      日本薬剤学会第31年会
    • Place of Presentation
      長良川国際会議場(岐阜県岐阜市)
    • Year and Date
      2016-05-20
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] クロピドグレルの関与する薬物間相互作用のカセットドーズ臨床試験に基づいたメカニズム解析とin vitro試験に基づいた予測.2016

    • Author(s)
      Soo-Jin Kim, 吉門 崇, 家入 一郎, 前田 和哉, 木村 美由紀, 入江 伸, 楠原 洋之, 杉山 雄一.
    • Organizer
      日本薬剤学会第31年会
    • Place of Presentation
      長良川国際会議場(岐阜県岐阜市)
    • Year and Date
      2016-05-20
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Clopidogrel-mediated drug-drug interaction on CYP2C8 and OATP1B1: in vitro inhibitory effect and in vivo clinical study.2016

    • Author(s)
      Kim S.J, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Prediction of inter-individual differences in pharmacokinetics and drug interactions of pravastatin using physiologically based pharmacokinetics model with Monte Carlo simulation.2016

    • Author(s)
      Matsumoto T, Toshimoto K, Chiba K, Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Identification of GCDCA-S as endogenous biomarkers for OATP1B1 and OATP1B3 in healthy subject.2016

    • Author(s)
      Takehara I, Terashima H, Nakayama T, Yoshikado T, Yoshida M, Furihata K, Watanabe N, Maeda K, Ando O, Sugiyama Y, Kusuhara H.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Analysis of drug-drug interactions caused by the inhibition of hepatic organic anion transporting polypeptides using a rational physiologically based pharmacokinetic model and parameters obtained from human hepatocytes.2016

    • Author(s)
      Yoshikado T, Toshimoto K, Sugiyama Y.
    • Organizer
      Experimental Biology 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-04-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Are inhibition constants (Ki) correctly estimated using only the blood concentration time profile of substrate drugs with and without co-administration of inhibitor drugs?2016

    • Author(s)
      Toshimoto K, Tomoda Y, Chiba K, Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-15
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] OATPs/CYP3A dual基質の薬物相互作用試験に基づいた肝消失律速過程の解析.2016

    • Author(s)
      吉門 崇, 降旗 聖子, 寺島 花野, 中山 丈史, 石亀 啓子, 常本 和伸, 前田 和哉, 楠原 洋之, 降旗 謙一, 杉山 雄一.
    • Organizer
      日本薬剤学会第31年会
    • Place of Presentation
      長良川国際会議場(岐阜県岐阜市)
    • Year and Date
      2016-05-20
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] The Use of“Extended Clearance Concept”and PBPK Modeling to Interpret Clinical Outcomes from In Vitro Metabolism and Transport Data; focusing on the transporters in the liver.2016

    • Author(s)
      Sugiyama Y.
    • Organizer
      7th Clinically Relevant Drug Transporters
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2016-06-22
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Analysis of nonlinear pharmacokinetics of highly albumin-bound compound.2016

    • Author(s)
      Fukuchi Y, Mori T, Asaumi R, Nunoya K, Imawaka H, Toshimoto K, Miyauchi S, Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] The novel physiologically based pharmacoki- netics (PBPK) model to investigate transporter-mediated disposition and clearance of metformin in humans.2016

    • Author(s)
      Nishiyama K, Toshimoto K, Ishiguro N, Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] "Albumin- mediated" hepatic transport: extrapolation to in vivo hepatic clearance from in vitro uptake data by suspended human hepatocytes in the presence of varied albumin concentrations.2016

    • Author(s)
      Sugiyama Y, Kim S.J, Lee K.R, Miyauchi S.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Analysis of complex drug-drug interactions of cerivastatin using physiol- ogically based pharmacokinetic (PBPK) modeling.2016

    • Author(s)
      Yao Y, Toshimoto K, Kim S.J, Yoshikado T, Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-14
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 創薬、臨床開発におけるリバーストランスレーショナルリサーチ(rTR)の重要性.2016

    • Author(s)
      杉山 雄一.
    • Organizer
      ライフサイエンスネットワーク形成事業(医薬品)平成28年度シンポジウム
    • Place of Presentation
      パシフィックホテル沖縄(沖縄県那覇市)
    • Year and Date
      2016-09-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] PBPK model of rifampicin incorporating its hepatic uptake and auto-induction processes to predict various types of DDIs such as CYP3A/2C9 inductions and OATPs inhibitions.2016

    • Author(s)
      Asaumi R, Toshimoto K, Kudo T, Sawada T, Tobe Y, Kono K, Ito K, Nunoya K, Imawaka H, Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-15
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Estimation of hepatic uptake transporter OATP1B1 variability: Influence of passive diffusion and metabolic intrinsic clearance on repaglinide AUC variability.2016

    • Author(s)
      Chiba K, Takahashi H, Kim S.J, Takatsu T, Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-14
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Perspective on transporter research; use of physiologically based pharmacokinetic modeling to predict roles of drug transporters in target tissue drug exposures.2016

    • Author(s)
      Sugiyama Y.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Establishment of a Physiologically-based Pharmacokinetic Modeling of CPT-11 and Its Metabolites Using the Cluster Newton Method: Its Application to a Virtual Clinical Study.2015

    • Author(s)
      Toshimoto K, Sugiyama Y.
    • Organizer
      日本薬物動態学会第30回年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-11-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Can we predict nonlinear pharmacokinetics of orally administered compounds at early stage of drug development?2015

    • Author(s)
      Tomaru A, Ishigame K, Toshimoto K, Sugiyama Y.
    • Organizer
      日本薬物動態学会第30回年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-11-13
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] サンドイッチ培養ヒト肝細胞を用いたスタチンの肝消失律速過程の予測.2015

    • Author(s)
      吉門 崇, Rafal P. Witek, 杉山 雄一.
    • Organizer
      日本薬剤学会第30年会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] CPT-11 の仮想臨床試験(Virtual Clinical Study)による臨床試験の再現.2015

    • Author(s)
      年本 広太, 杉山 雄一.
    • Organizer
      第36回日本臨床薬理学会学術総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-12-09
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 医薬品開発における数理モデルの活用.2015

    • Author(s)
      杉山 雄一
    • Organizer
      第34 回生命科学シンポジウム
    • Place of Presentation
      東邦大学(千葉県船橋市)
    • Year and Date
      2015-10-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] PBPK モデルを用いたrepaglinide の複雑な薬物間相互作用の解析.2015

    • Author(s)
      Soo-Jin Kim, 八尾 祉顕, 年本 広太, 吉門 崇, 杉山 雄一.
    • Organizer
      日本薬剤学会第30年会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Cassette Microdosing Design to Identify Optimal Pharmacokinetic Properties.2015

    • Author(s)
      Sugiyama Y.
    • Organizer
      2015 Annual Meeting of American College of Clinical Pharmacology
    • Place of Presentation
      San Francisco, US.
    • Year and Date
      2015-09-26
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Imaging Hepatic Concentrati- on and Biliary Excretion of Drugs.2015

    • Author(s)
      Sugiyama Y.
    • Organizer
      18th International Conference on Drug-Drug Interactions
    • Place of Presentation
      Seattle, US.
    • Year and Date
      2015-06-30
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] A novel model considering a change in medium unbound fraction caused by a significant ligand-transporter binding can feasibly explain the "albumin-mediated hepatic uptake" phenomenon.2015

    • Author(s)
      Miyauchi S, Masuda M, Tanaka Y, Iwakado S, Shimono K, Kim S.J, Sugiyama Y.
    • Organizer
      日本薬物動態学会第30回年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-11-14
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] トランスポーターが関与する肝取り込みおよび排出過程のサンドイッチ培養ヒト肝細胞を用いた定量的評価-肝消失律速過程の解析-2015

    • Author(s)
      吉門 崇, 杉山 雄一.
    • Organizer
      第10回トランスポーター研究会年会
    • Place of Presentation
      慶應義塾大学薬学部(東京都港区)
    • Year and Date
      2015-06-20
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Transporters-role in pharma- cokinetics/pharmacodynamics/toxicodynamics of drugs.2015

    • Author(s)
      Sugiyama Y.
    • Organizer
      BioMedical Transporters 2015
    • Place of Presentation
      Lugano, Switzerland
    • Year and Date
      2015-08-09
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] シクロスポリンの関わる時間依存的なOATP 阻害を説明する数理モデル.2015

    • Author(s)
      設楽 悦久, 芝崎 茂樹, 杉山 雄一.
    • Organizer
      日本薬剤学会第30年会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 肝取り込みトランスポーターOATPs および代謝酵素CYP3A4 のdual 基質薬の関与する薬物間相互作用の臨床解析.2015

    • Author(s)
      杉山 雄一, 吉門 崇, 降旗 聖子, 寺島 花野, 中山 丈史, 石亀 啓子, 常本 和伸, 前田 和哉, 楠原 洋之, 降旗 謙一.
    • Organizer
      第36回日本臨床薬理学会学術総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-12-09
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Significance of Uptake and Efflux Transporters in the Liver.2015

    • Author(s)
      Sugiyama Y.
    • Organizer
      20th North American ISSX Meeting
    • Place of Presentation
      Orland, US
    • Year and Date
      2015-10-20
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Clarification of the mechanism of clopidogrel-mediated drug-drug interaction on the pharmacokinetics of repaglinide in a clinical cassette small-dose study.2015

    • Author(s)
      Kim S.J, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y.
    • Organizer
      日本薬物動態学会第30回年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 胆汁形成を担うトランスポーターのin vitro機能評価系に基づいた薬物誘発性胆汁うっ滞型肝障害のリスク評価.2015

    • Author(s)
      吉門 崇, 杉山 雄一.
    • Organizer
      日本動物実験代替法学会第28回大会,
    • Place of Presentation
      ワークピア横浜(神奈川県横浜市)
    • Year and Date
      2015-12-10
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] PBPK モデルを用いたCPT-11の副作用と関連性の高い因子の探索.2015

    • Author(s)
      年本 広太, 杉山 雄一.
    • Organizer
      日本薬剤学会第30年会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] The Use of “Extended Clearance Concept” and PBPK Modeling to Interpret Clinical Outcomes from In Vitro Metabolism and Transport Data.2015

    • Author(s)
      Sugiyama Y.
    • Organizer
      IVAL Hepatocyte Technology Conference and Workshops 2015
    • Place of Presentation
      Boston, US
    • Year and Date
      2015-04-14
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 薬物動態研究を基盤とした医薬品開発の未来像.2015

    • Author(s)
      杉山 雄一
    • Organizer
      創剤研究コンソーシアム製剤技術研究コンソーシアム合同シンポジウム
    • Place of Presentation
      立命館大学(滋賀県草津市)
    • Year and Date
      2015-06-20
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Construction of physiologically-based pharmacokinetic (PBPK) model of rifampicin to predict metabolic enzyme induction- and hepatic uptake transporter inhibition-mediated drug-drug interaction (DDI).2015

    • Author(s)
      Asaumi R, Nunoya K, Imawaka H, Sugiyama Y.
    • Organizer
      日本薬物動態学会第30回年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 薬物相互作用(DDI)ガイドラインの科学的基盤.2015

    • Author(s)
      杉山 雄一
    • Organizer
      第36回日本臨床薬理学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-12-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Predicting complex drug-drug interactions of repaglinide using physiologically based pharmacokinetic (PBPK) models with in vitro Ki data.2015

    • Author(s)
      Soo-Jin Kim, 八尾 祉顕, 年本 広太, 吉門 崇, 杉山 雄一.
    • Organizer
      第36回日本臨床薬理学会学術総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-12-09
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 肝臓におけるトランスポーターを介した薬物間相互作用の生理学的薬物速度論モデルに基づいた解析法の構築.2015

    • Author(s)
      吉門 崇, 杉山 雄一.
    • Organizer
      第36回日本臨床薬理学会学術総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-12-09
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 10 年後の創薬~薬剤学への期待.2015

    • Author(s)
      杉山 雄一
    • Organizer
      日本薬剤学会創立30 周年記念シンポジウム
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2015-05-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Transporters-role in pharma- cokinetics/pharmacodynamics/toxicodynamics of drugs.2015

    • Author(s)
      Sugiyama Y.
    • Organizer
      45th Annual Meeting of The Korean Society of Pharmaceutical Sciences and Technology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-11-19
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Comparative Evaluation of Unbound Intracellular-Medium (Plasma) Concentration Ratios (Kp,uu) of Poorly-Metabolized Anionic Drugs Using Rat and Human Hepatocytes.2015

    • Author(s)
      Nakada T, Ikejiri K, Toshimoto K, Ogawa K, Hisanaga N, Kusuhara H, Maeda K, Sugiyama Y.
    • Organizer
      日本薬物動態学会第30回年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-11-14
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] マイクロドース臨床試験と薬物動態予測.2015

    • Author(s)
      杉山 雄一
    • Organizer
      第29 回日本医学会総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-04-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] A clinical drug interaction study using hepatic OATPs/CYP3A dual substrates: analysis of the rate-determining process based on the extended clearance concept.2015

    • Author(s)
      Yoshikado T, Furihata S, Terashima H, Nakayama T, Ishigame K, Tsunemoto K, Maeda K, Kusuhara H, Furihata K, Sugiyama Y.
    • Organizer
      日本薬物動態学会第30回年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 薬物動態・薬効・副作用の個人間変動を定量的に理解する2014

    • Author(s)
      杉山 雄一
    • Organizer
      第357回CBI学会研究講演会
    • Place of Presentation
      東京都文京区、東京大学山上会館2階 大会議室
    • Year and Date
      2014-12-12
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 肝OATPを介した薬物間相互作用のPBPKモデルを用いた解析 -腸肝循環を考慮した合理的なモデルへの発展-2013

    • Author(s)
      吉門 崇,吉田 健太,中田 智久,小谷 直生,前田 和哉,杉山 雄一
    • Organizer
      日本薬剤学会 第28年会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] トランスポーターを介した薬物間相互作用予測のための腸肝循環およびIn vitro膜透過性を考慮した生理学的薬物速度論モデルの提案2013

    • Author(s)
      吉門 崇,吉田 健太,前田 和哉,杉山 雄一
    • Organizer
      日本薬物動態学会 第28回年会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Do PBPK models predict complex DDIs where the alterations of transport and metabolism/excretion take place simultaneously?2013

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      ASCPT 2013 Annual Meeting
    • Place of Presentation
      JW Marriott, Indianapolis, Indiana, US
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 病態時および個体差を考慮したPK/PD予測の方法論2013

    • Author(s)
      杉山 雄一
    • Organizer
      日本薬物動態学会 第27回ワークショップ
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Quantitative assessment of transporter effects on pharmacokinetics and pharmaco /toxicodynamics of drugs.2013

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      10th International ISSX Meeting
    • Place of Presentation
      Westin Harbour Castle Hotel, Toronto, Canada
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] PARAMETER OPTIMIZATION IN PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODEL FOR THE PREDICTION OF TRANSPORTER-MEDIATED DRUG-DRUG INTERACTIONS WITH A NEW GLOBAL PARAMETER OPTIMIZATION METHOD.2013

    • Author(s)
      Yoshida K, Maeda K, Kusuhara H, Konagaya A, Sugiyama Y.
    • Organizer
      ASCPT 2013 Annual Meeting
    • Place of Presentation
      JW Marriott, Indianapolis, Indiana, US
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 肝臓内非結合型薬物濃度を見積もるための簡便なin vitro実験法の提案2013

    • Author(s)
      杉山 雄一,池尻 和明,前田 和哉,楠原 洋之
    • Organizer
      日本薬剤学会 第28年会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Transporter-mediated drug-drug interactions in the liver from in vitro data2012

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      DDI-2012 15th International Conference on Drug-drug Interactions:
    • Place of Presentation
      the Red Lion Hotel, Seattle, US
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 薬物動態の支配要因及び創薬標的としての薬物トランスポーター2012

    • Author(s)
      杉山雄一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌、北海道(招待講演)
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] 薬物動態の支配要因及び創薬標的としての薬物トランスポーター2012

    • Author(s)
      杉山雄一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌、北海道
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Construction of physiologically-based pharmacokinetic models explaining drug-drug interactions via the inhibition of organic anion transporting polypeptides (OATPs)2012

    • Author(s)
      Yoshikado T, Maeda K, Nakada T, Kotani N, Yoshida K, Sugiyama Y.
    • Organizer
      19th Microsomes and Drug Oxidations (MDO) and 12th European ISSX Meeting
    • Place of Presentation
      Grand Hotel Huis ter Duin, Noordwijk aan Zee, the Netherlands
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Quantitative analyses of drug-drug interactions between statins and cyclosporine A using physiologically-based pharmacokinetic models2012

    • Author(s)
      Takashi Yoshikado, Kazuya Maeda, Tomohisa Nakada, Yoshihisa Shitara, Kenta Yoshida, Yuichi Sugiyama
    • Organizer
      27th JSSX Annual Meeting
    • Place of Presentation
      Chiba, Japan
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Microdosing and PET studies in drug transporter research2012

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      19th Microsomes and Drug Oxidations (MDO) and 12th European ISSX Meeting
    • Place of Presentation
      Grand Hotel Huis ter Duin, Noordwijk aan Zee, the Netherlands
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Advance in physiology, pharmacology, & pharmaceutical sciences: advances in research of drug transporters and metabolic enzymes: implications in drug development2012

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      Modern Therapeutics 2012
    • Place of Presentation
      University of Toronto, Toronto Canada
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Transporters : clinical relevance and IVIVE in drug discovery2011

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      The 20^<th> Helsinki Drug Research Congress (HDR 2011)
    • Place of Presentation
      Helsinki, Finland(招待講演)
    • Year and Date
      2011-09-18
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] トランスポーターを介する生体膜輸送論:薬物間相互作用、遺伝子多型の解析2011

    • Author(s)
      杉山雄一
    • Organizer
      北海道大学大学院薬学系研究科特別講演会
    • Place of Presentation
      札幌、北海道
    • Year and Date
      2011-06-23
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Transporters : clinical relevance and IVIVE in drug discovery2011

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      The 20^th Helsinki Drug Research Congress(HDR 2011)
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2011-09-18
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Drug Transporters : Roles in new drug discovery and development2011

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      The 8^<th> symposium on New Developments in Clinical Pharmacy and Clinical Pharmacology/8^<th> Retrometabolism Based Drug Design and Targeting Conference
    • Place of Presentation
      Graz, Austria(招待講演)
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Predictions of transporter-mediated drug-drug interaction in the liver from in vitro data2011

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      The 14^<th> International Conference on Drug-Drug interactions (DDI-2011)
    • Place of Presentation
      Seattle, WA, USA(招待講演)
    • Year and Date
      2011-06-07
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Drug transporters : Rolesin new drug discovery and development2011

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      Gordon Research Conference on Drug Metabolism
    • Place of Presentation
      Holderness, NH, USA
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Transporters on the target organs and clearance organs are responsible for drug induced toxicities2011

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      Bio Medical Transporters 2011
    • Place of Presentation
      Grindelvald, Switzerland
    • Year and Date
      2011-08-08
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Predictions of transporter-mediated drug-drug interaction in the liver from in vitro data2011

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      The 14^th International Conference on Drug-Drug interactions(DDI-2011)
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2011-06-07
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Application of PBPK modeling and clearance concept to drug showing transporter-mediated distribution and clearance in humans2011

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      The 4^th Asia Pacific Regional ISSX Meeting
    • Place of Presentation
      Tainan, Taiwan
    • Year and Date
      2011-04-23
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] The importance of organic anion transporting polypeptide (OATP) 2B1 to the intestinal drug absorption2011

    • Author(s)
      Shinya Fukizawa, Kazuya Maeda, Mayuko Miyagawa, Ichiro Ieiri, Miyuki Kimura, Shin Irie, Kazuhide Iwasaki, Yuichi Sugiyama
    • Organizer
      International Symposium on BA/BE of Oral Drug Products
    • Place of Presentation
      神戸、兵庫県
    • Year and Date
      2011-06-29
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Transporters on the target organs and clearance organs are responsible for drug induced toxicities2011

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      BioMedical Transporters 2011
    • Place of Presentation
      Grindelvald, Switzerland(招待講演)
    • Year and Date
      2011-08-08
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] The importance of organic anion transporting polypeptide(OATP) 2B1 to the intestinal drug absorption2011

    • Author(s)
      Shinya Fukizawa、Kazuya Maeda、Mayuko Miyagawa、Ichiro Ieiri、Miyuki Kimura、Shin Irie、Kazuhide Iwasaki、Yuichi Sugiyama
    • Organizer
      International Symposium on BA/BE of Oral Drug Products
    • Place of Presentation
      神戸、兵庫県
    • Year and Date
      2011-06-29
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] 薬物トランスポーター機能解析に活かすPETイメージング:創薬への応用2011

    • Author(s)
      杉山雄一
    • Organizer
      岡山分子イメージング高度専門人材育成事業キックオフシンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2011-02-02
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Quantitative prediction of clinically relevant transporter-mediated drug-drug interactions from in vitro data2011

    • Author(s)
      Kenta Yoshida、Kazuya Maeda、YuichiSugiyama
    • Organizer
      International Symposium on BA/BE of Oral Drug Products
    • Place of Presentation
      神戸、兵庫県
    • Year and Date
      2011-06-29
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] トランスポーターを介する生体膜輸送論:薬物間相互作用、遺伝子多型の解析2011

    • Author(s)
      杉山雄一
    • Organizer
      北海道大学大学院薬学系研究科 特別講演会
    • Place of Presentation
      札幌、北海道(招待講演)
    • Year and Date
      2011-06-23
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Application of PBPK modeling and clearance concept to drug showing transporter-mediated distribution and clearance in humans2011

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      The 4^<th> Asia Pacific Regional ISSX Meeting
    • Place of Presentation
      Tainan, Taiwan(招待講演)
    • Year and Date
      2011-04-23
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Drug transporters : Roles in new drug discovery and development2011

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      Gordon Research Conference on Drug Metabolism
    • Place of Presentation
      Holderness, NH, USA(招待講演)
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Drug Transporters : Rolesin new drug discovery and development2011

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      The 8^th symposium on New Developments in Clinical Pharmacy and Clinical Pharmacology/8^th Retrometabolism Based Drug Design and Targeting Conference
    • Place of Presentation
      Graz, Austria
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Microdosing in human trials2010

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      The 6th Uppsala Spring Meeting
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      2010-04-13
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] IVIVE for hepatic and renal transporters2010

    • Author(s)
      Hiroyuki Kusuhara, Yuichi Sugiyama
    • Organizer
      2010 FIP PSWC/RAPS annual meeting and exposition
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2010-11-17
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Drug Metabolizing Enzymes and Transporters in Drug-Drug Interactions : A Pharmacokinetic Treatment2010

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      13th International Conference on Drug-Drug Interactions
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2010-06-14
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Clinical significance of pharmacogenomics and drug-drug interaction in transporter-mediated pharmacokinetics/pharmacodynamics2010

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      TWELFTH BUFFALO PHARMACEUTICS SYMPOSIUM
    • Place of Presentation
      Buffalo, USA
    • Year and Date
      2010-07-30
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Tramsporters2010

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      Eighth International Workshop on Pharmacodyna mics of anticancer agents
    • Place of Presentation
      箱根
    • Year and Date
      2010-10-18
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Eighth International2010

    • Author(s)
      Yuichi Sugiyama Tramsporters
    • Organizer
      Workshop on Pharmacodynamics of anticancer agents
    • Place of Presentation
      箱根
    • Year and Date
      2010-10-18
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Theoretical Prediction of transporter-mediated drug-drug interaction2010

    • Author(s)
      Kazuya Maeda, Yuichi Sugiyama
    • Organizer
      2010 FIP PSWC/RAPS annual meeting and exposition
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2010-11-15
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Theoretical Prediction of transporter-mediated drug-drug interaction2010

    • Author(s)
      Kazuya Maeda, Yuichi Sugiyama
    • Organizer
      2010 FIP PSWC/AAPS annual meeting and exposition
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2010-11-15
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Rate-determining process of a co-substrate of uptake transporter and metabolizing enzyme in the liver2010

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      MD02010
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-05-17
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] IVIVE for hepatic and renal transporters2010

    • Author(s)
      Hiroyuki Kusuhara, Yuichi Sugiyama
    • Organizer
      2010 FIP PSWC/AAPS annual meeting and exposition
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2010-11-17
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Rate-determining process of a co-substrate of uptake transporter and metabolizing enzyme in the liver2010

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      MDO2010
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-05-17
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] 医薬品の探索・開発における薬物トランスポーター研究の重要性2010

    • Author(s)
      杉山雄一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] CAN DRUG CONCENTRATION IN THE CEREBROSPINAL FLUID BE A SURROGATE FOR THE UNBOUND CONCENTRATION OF CNS DRUGS IN THE BRAIN?: In vitro to in vivo prediction2009

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      North American ISSX
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2009-10-18
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Clinical significance of pharmacogenomics and drug-drug interaction in OATPs-mediated pharmacokinetics/pharmacodynamics2009

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      BioMedical Transporters2009
    • Place of Presentation
      Thun, Switzerland
    • Year and Date
      2009-08-09
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] ROLE OF MURINE Oatpla4 IN THE HEPATIC UPTAKE OF DRUGS IN MICE2009

    • Author(s)
      Junichi Takano, Kazuya Maeda, Yuichi Sugiyama
    • Organizer
      Asian Federation for Pharmaceutical Sciences 2009
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-17
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Drug Transporters in the New Drug Discovery and Development2009

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      3rd Asian Pacific Regional Meeting of ISSX
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2009-05-10
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] ヒト薬物トランスポーターの遺伝子多型がグリチルリチンの薬物動態に与える影響2009

    • Author(s)
      前田和哉, 滝川一, 出堀泰之, 江頭徹, 杉山雄一
    • Organizer
      日本人類遺伝学会第54回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-24
    • Data Source
      KAKENHI-PROJECT-20018006
  • [Presentation] QUANTITATIVE PREDICTION OF THE CLEARANCE PATHWAYS OF TRANSPORTER SUBSTRATES FROM IN VITRO EXPERIMENTS2009

    • Author(s)
      Kazuya Maeda, Yuichi Sugiyama
    • Organizer
      7th Retrometabolism Based Drug Design and Targeting
    • Place of Presentation
      Florida, USA
    • Year and Date
      2009-05-12
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Clinical significance of pharmacogenomics and drug-drug interaction in OATPs-mediated pharmacokinetics/pharmacodynamics2009

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      BioMedical Transporters 2009
    • Place of Presentation
      Thun, Switzerland
    • Year and Date
      2009-08-09
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Clinical significance of pharmacogenomics and drug-drug interaction in OATPs-mediated pharmacokinetics/pharmacodynamics2009

    • Author(s)
      杉山雄一
    • Organizer
      BioMedical Transporters 2009
    • Place of Presentation
      Thun, Switzerland
    • Year and Date
      2009-08-10
    • Data Source
      KAKENHI-PROJECT-20018006
  • [Presentation] ROLE OF MURINE Oatp1a4 IN THE HEPATIC UPTAKE OF DRUGS IN MICE2009

    • Author(s)
      Junichi Takano, Kazuya Maeda and Yuichi Sugiyama
    • Organizer
      Asian Federation for Pharmaceutical Sciences 2009
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-17
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] CAN DRUG CONCENTRATION IN THE CEREBROSPINAL FLUID BE A SURROGATE FOR THE UNBOUND CONCENTRATION OF CNS DRUGS IN THE BRAIN? : In vitro to in vivo prediction2009

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      North American ISSX
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2009-10-18
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] QUANTITATIVE PREDICTION OF THE CLEARANCE PATHWAYS OF TRANSPORTER SUBSTRATES FROM IN VITRO EXPERIMENTS2009

    • Author(s)
      Kazuya Maeda, Yuichi Sugiyama
    • Organizer
      7^<th> Retrometabolism Based Drug Design and Targeting
    • Place of Presentation
      Florida, USA
    • Year and Date
      2009-05-12
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] QUANTITATIVE PREDICTION OF THE CLEARANCE PATHWAYS OF TRANSPORTER SUBSTRATES FROM IN VITRO EXPERIMENTS2009

    • Author(s)
      Kazuya Maeda and Yuichi Sugiyama
    • Organizer
      7^th Retrometabolism Based Drug Design and Targeting
    • Place of Presentation
      Florida, USA
    • Year and Date
      2009-05-12
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] トランスポーターを介した薬物間相互作用による血漿中・組織中濃度の変動のin vitro実験に基づく定量的予測法の検討2009

    • Author(s)
      前田和哉、北村吏司、杉山雄一
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡
    • Year and Date
      2009-05-22
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Integration of In Vitroand In Vivo Data of Transporter Mediated Drug-drug Interaction and Pharmacogenomics2008

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      2nd Asian-Pasific ISSX meeting
    • Place of Presentation
      上海、中国
    • Year and Date
      2008-05-12
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] 薬物トランスポーターが関与する薬物間相互作用の事例解析と予測法の構築へ向けて2008

    • Author(s)
      前田和哉、杉山雄一
    • Organizer
      第12回薬物動態談話会セミナー
    • Place of Presentation
      つくば
    • Year and Date
      2008-08-21
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] トランスポーターレベルの薬物間相互作用:in vitro実験データと臨床データの対応付け2008

    • Author(s)
      前田和哉、杉山雄一
    • Organizer
      CBI研究講演会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-14
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] SEARCH AND VALIDATION OF IN VIVO PROBE DRUGS FOR FUNCTIONAL ANALYSIS OF OAT1 AND OAT3 IN HUMANS2008

    • Author(s)
      Tian Y, Maeda K, Kumagai Y, Kondo T, Kusuhara H and Sugiyama Y
    • Organizer
      日本薬物動態学会第23回年会
    • Place of Presentation
      熊本
    • Year and Date
      2008-11-01
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Integration of In Vitro and In Vivo Data of Transporter Mediated Drug?drug Interaction and Pharmacogenomics2008

    • Author(s)
      Sugiyama Y
    • Organizer
      2nd Asian7Pasific ISSX meeting
    • Place of Presentation
      上海、中国
    • Year and Date
      2008-05-12
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] トラとスポーターの遺伝子多型が薬物動態・薬効に与えるインパクト〜OATP1B1, BCRPを中心に〜2008

    • Author(s)
      前田和哉、杉山雄一
    • Organizer
      日本臨床薬理学会第29回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-05
    • Data Source
      KAKENHI-PROJECT-20018006
  • [Presentation] Non-selective inhibitors of hepatic influx and efflux transp orters: Implications to pharmacokinetics and hepatic drug di sposition2008

    • Author(s)
      Sugiyama Y
    • Organizer
      FDA Critical Path Transporter Workshop
    • Place of Presentation
      Bethesda, USA
    • Year and Date
      2008-10-02
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] P-glycoprotein and other efflux transporters (Bcrp, Mrp2) on the luminal membrane in absorption, distribution, and elimination2008

    • Author(s)
      Sugiyama Y
    • Organizer
      2008 AAPS Annual Meeting & Exposition
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2008-11-17
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] P-glycoprotein and other efflux transporters(Bcrp, Mrp2) on the luminal membrane in absorption, distribution, and elimination2008

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      2008 AAPS Annual Meeting & Exposition
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2008-11-17
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] トランスポーターレベルめ薬物間相互作用:in vitro実験データと臨床デー汐の対応付け2008

    • Author(s)
      前田和哉、杉山雄一
    • Organizer
      CBI研究講演会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-14
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Integration of In Vitro and In Vivo Data of Transporter Mediated Drug-drug Interaction and Pharmacogenomics2008

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      2nd Asian-Pasific ISSX meeting
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2008-05-12
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] Non-selective inhibitors of hepatic influx and efflux transporters : Implications to pharmacokinetics and hepatic drug disposition2008

    • Author(s)
      Yuichi Sugiyama
    • Organizer
      FDA Critical Path Transporter Workshop
    • Place of Presentation
      Bethesda, USA
    • Year and Date
      2008-10-02
    • Data Source
      KAKENHI-PROJECT-20249008
  • [Presentation] 肝細胞血管側の胆汁酸排泄輸送体ABCC3/MRP3遺伝子多型の機能解析2007

    • Author(s)
      伊藤晃成, 小林和弘, 高田龍平, 杉山雄一, 鈴木洋史
    • Organizer
      第29回胆汁酸研究会
    • Place of Presentation
      つくば
    • Year and Date
      2007-11-24
    • Data Source
      KAKENHI-PROJECT-17081006
  • [Presentation] Assessment of Transport of New Drug Candidates to Predict the optimum ADME properties2006

    • Author(s)
      Sugiyama Y
    • Organizer
      2006 AAPS Annual Meeting and Exposition
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2006-10-31
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209005
  • [Presentation] Computational and in vitro approaches for predicting drug metabolism and pharmacokinetics in humans2006

    • Author(s)
      Sugiyama Y
    • Organizer
      The 15th World Congress of Pharmacology (IUPHAR2006)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2006-07-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209005
  • [Presentation] Computational and in vitro Approaches for Predicting Drug Metabolism and Pharmacokinetics in Humans2006

    • Author(s)
      Sugiyama Y
    • Organizer
      The 15th World Congress of Pharmacology (IUPHAR2006)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2006-07-27
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209005
  • [Presentation] Influx and Efflux Transporters in the Blood Brain and Blood-CSF Barriers2006

    • Author(s)
      Sugiyama Y
    • Organizer
      The 15t Asian- Pasific ISSX Meeting
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2006-05-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209005
  • [Presentation] Drug Transporters in the new drug discovery and development2006

    • Author(s)
      Sugiyama Y
    • Organizer
      The 33rd Annual Meeting of the Controlled Release Society
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2006-07-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209005
  • [Presentation] Influx and Efflux Transporters in the Blood Brain and Blood-CSF Barriers2006

    • Author(s)
      Sugiyama Y
    • Organizer
      The 1st Asian-Pacific ISSX Meeting
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2006-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209005
  • [Presentation] Effect of phosphorylation of Akt on polarized expression of human BCRP/ABCG2.2006

    • Author(s)
      Takada T, Suzuki H, Sugiyama Y.
    • Organizer
      ABC2006 FEBS Special Meeting on ABC Proteins
    • Place of Presentation
      Innsbruck, Austria.
    • Data Source
      KAKENHI-PROJECT-17081006
  • [Presentation] Drug transporters in the new drug discovery and development2006

    • Author(s)
      Sugiyama Y
    • Organizer
      The 33rd Annual Meeting of the Controlled Release Society
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2006-07-26
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209005
  • [Presentation] Analysis of drug-drug interactions between cerivastatin and interacting drugs, cyclosporine A and gemfibrozil, using physiologically based pharmacokinetic (PBPK) model.

    • Author(s)
      Kim S.J, Yao Y, Yoshikado T, Toshimoto K, Sugiyama Y
    • Organizer
      19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
    • Place of Presentation
      California, US
    • Year and Date
      2014-10-19 – 2014-10-23
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Translational Clinical Research of OATPs and MRP2 Activity Using Positron Emission Tomography (PET) with 11C-Dehydropravastatin.

    • Author(s)
      Shingaki T, Tanaka M, Ishii A, Katayama Y, Tazawa S, Wada Y, Cui Y, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y
    • Organizer
      World Molecular Imaging Congress 2014
    • Place of Presentation
      Soul, Korea
    • Year and Date
      2014-09-17 – 2014-09-20
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] サンドイッチ培養ヒト肝 細胞を用いたスタチン系薬剤の肝臓除去における律速過程の予測

    • Author(s)
      吉 門 崇、Rafal P. Witek、杉山 雄一
    • Organizer
      日本動物実験代替法学会 第27回大会
    • Place of Presentation
      神奈川県横浜市、横浜国立大学
    • Year and Date
      2014-12-05 – 2014-12-07
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] CLINICAL EVALUATION OF OATPs AND MRP2 ACTIVITY USING POSITRON EMISSION TOMOGRAPHY (PET) WITH [11C]DEHYDROPRAVASTATIN

    • Author(s)
      Shingaki T, Tanaka M, Ishii A, Katayama Y, Tazawa S, Wada Y, Cui Y, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y
    • Organizer
      19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
    • Place of Presentation
      California, US
    • Year and Date
      2014-10-19 – 2014-10-23
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Establishing a versatile analysis method of drug-drug interactions with the physiologically-based pharmacokinetic model using the Cluster Newton Method.

    • Author(s)
      Toshimoto K, Yoshida K, Yoshikado T, Maeda K, Kusuhara H, Konagaya A, Sugiyama Y
    • Organizer
      19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
    • Place of Presentation
      California, US
    • Year and Date
      2014-10-19 – 2014-10-23
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Quantitative assessment of a role of hepatic transporters in the hepatic clearance and drug-drug interactions.

    • Author(s)
      Sugiyama Y
    • Organizer
      19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
    • Place of Presentation
      California, US
    • Year and Date
      2014-10-19 – 2014-10-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Clinical significance of uptake and efflux transporters in the liver.

    • Author(s)
      Sugiyama Y
    • Organizer
      7th SFB35-Symoisum
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2014-09-08 – 2014-09-10
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Complex DDIs: The Use of "extended clearance concept" and "PBPK Modeling" to interpet the clinical DDI outcomes from in vitro metabolism and transport data.

    • Author(s)
      Sugiyama Y
    • Organizer
      AAPS Annual Meeting and Exposition, PSJ-AAPS symposium
    • Place of Presentation
      California, US
    • Year and Date
      2014-11-03 – 2014-11-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] Prediction of transporter- and enzyme-mediated complicated drug-drug interaction: taking Cerivastatin, withdrawn from the market due to its induced rhabdomyolysis as an example of victim drug

    • Author(s)
      Kim S.J, Yao Y, Toshimoto K, Yoshikado T, Sugiyama Y.
    • Organizer
      日本動物実験代替法学会 第27回大会
    • Place of Presentation
      神奈川県横浜市、横浜国立大学
    • Year and Date
      2014-12-05 – 2014-12-07
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] トランスポーターを介した薬物間相互作用のモデリング事例

    • Author(s)
      吉門 崇、杉山 雄一
    • Organizer
      日本薬剤学会第29年会
    • Place of Presentation
      埼玉県さいたま市、大宮ソニックシティビル
    • Year and Date
      2014-05-20 – 2014-05-22
    • Data Source
      KAKENHI-PROJECT-24229002
  • [Presentation] 機械学習を用いた9つの主要なin vivo薬物クリアランス経路のin silico予測

    • Author(s)
      年本 広太、若山 直美、堀田 駿、前田 和哉、石田 貴士、秋山 泰、杉山 雄一
    • Organizer
      日本動物実験代替法学会 第27回大会
    • Place of Presentation
      神奈川県横浜市、横浜国立大学
    • Year and Date
      2014-12-05 – 2014-12-07
    • Data Source
      KAKENHI-PROJECT-24229002
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  • 116.  崔 翼龍
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