Sugiyama Yuichi 杉山雄一

… Alternative Names

Researcher Number	80090471
Other IDs
External Links
Affiliation (Current)	2022: 城西国際大学, 薬学部, 特別栄誉教授
Affiliation (based on the past Project Information) *help	2022: 城西国際大学, 薬学部, その他 2021: 城西国際大学, 薬学部, 特別栄誉教授 2018 – 2020: 国立研究開発法人理化学研究所, 科技ハブ産連本部, 特別招聘研究員 2015 – 2017: 国立研究開発法人理化学研究所, イノベーション推進センター, 特別招聘研究員 2013 – 2014: 独立行政法人理化学研究所, イノベーション推進センター, 特別招聘研究員 … More
Review Section/Research Field	Principal Investigator Biological pharmacy / Physical pharmacy / 応用薬理学・医療系薬学 / Biological Sciences / Medical pharmacy / 医薬分子機能学 / Basic Section 47060:Clinical pharmacy-related / Drug development chemistry Except Principal Investigator Physical pharmacy / 応用薬理学・医療系薬学 … More
Keywords	Principal Investigator 胆汁排泄 / トランスポーター / cMOAT / MRP / 有機アニオン / biliary excretion / transporter / 薬物間相互作用 / MRP2 / 多剤耐性 … More Except Principal Investigator トランスポーター / 薬物速度論 / 胆汁排泄 / ABCトランスポーター / Pharmacokinetics / トランスジェニックマウス / 血液脳関門 / pharmacokinetics / 脳 / 血液-脳関門 / 血液-脳脊髄液関門 / チトクロームP450 / がん原物質活性化 / CYP1A1 / P450アロマターゼ / 有機アニオン / 有機アニオントランスポーター / 尿細管分泌 / 血液脳脊髄液関門 / 薬剤反応性 / 抗癌剤 / ヒト / 薬物送達システム / Drug delivery system / グルコ-ス / muscimol / glucose / P450 / ポリオウイルス / ウイルス受容体 / ドラッグデリバリー / Blood-brain barrier / Poliovirus / Virus receptor / Organ tropism / drug delivery / transporter / receptor / tissue targeting / blood-brain barrier / cloning / efflux pump / Brain / MRP / cMOAT / ベンゾジアゼピン / 脳毛細血管内皮細胞 / 脈絡叢上皮細胞 / P-糖蛋白 / ビンクリスチン / 遺伝子導入動物 / CYP2B6 / 一酸化窒素合成酵素 / 受容体介在性内在化 / ターゲティング / デリバリー / ウイルスベクター / G-CSF / 遺伝子導入 / 能動輸送 / 基質認識 / 相互作用 / シンクロナイゼーション / ベクトル輸送 / Oat3 / Oatp3 / RST / 性差 / 再呼吸 / プロドラッグ / Oatp1 / 薬物間相互作用 / 小腸上皮細胞 / 排出輸送 / 生理学 / 薬理学 / コレステロール / 尿酸 / 胆汁 / 翻訳後修飾 / 相互作用蛋白質 / PFIC / ABCC / MRP2 / 酸化的ストレス / 内在化 / プロテインキナーゼ / ABCB11 / BSEP / マウス / ファーマコキネテックス / 薬剤感受性 / スクリーニングシステム / リポソーム / マクロファージ / ライソゾーム / オプソニン / 補体レセプター / リポソ-ム / 細胞内運命 / DDS / クリアランス / 補体 / Liposome / Macrophage / Lysosome / Opsonin / Complement receptor / 培養神経細胞 / 分離神経細胞 / 3ー0ーmethylglucose / 2ーdeoxyglucose / 3ーOーmethylglucose / cerebellar granule cells in monolayer culture / isolated brain cells / 3-o-methylglucose / 2-deoxyglucose / 外挿 / 動物種差 / 遺伝子 / 薬物代謝 / 遺伝子相同性 / 実験動物 / 系統差 / アニマルスケールアップ / 遺伝的相同性 / 遺伝情報 / 薬物代謝酵素 / 薬物代謝能 / 疾患遺伝子 / 膜酵素 / 肝臓薬物代謝酵素 / 遺伝子地図 / ジーンバンク / 動物脳シナプス膜脂質 / EXTRAPOLATION / SPECIES DIFFERENCES / GENE / PHARMACOKINETICS / GENETIC HOMOLOGY / LABORAATORY ANIMALS / STRAIN DIFFERENCES / ANIMAL SCALE UP / 薬物体内動態 / 生理学的モデル / 細胞膜透過 / 薬物吸収 / 薬物ターゲッティング / ペプチド薬物 / 鎮痛薬 / Physiological model / Cell membrane permeation / Drug absorption / Drug targeting / Peptide drug / サルモネラ菌 / 変異原性試験 / 代謝的活性化 / 遺伝子多型 / 肺がん / がん原物質 / DNAアダクト / 発現制御 / 発現系 / CYP1A2 / アロマターゼ / Ahレセプター / 遺伝子導入マウス / CYP3A4 / Salmonella typhimurium / Mutation assay / Metabolic activation / Genetic polymorphism / Lung cancer / 細胞接着因子 / 癌細胞 / 転移 / 輸送担体 / ウイルス感染 / モノクローナル抗体 / Cell adhesion molecule / Drug delivery / Tumor cells / Transport carrier / effux pump / レセプター / 組織標的化 / ウイルス製剤 / ワクチン / 臓器選択性 / Vaccine / Blood-brain barrier : / Transgenic mouse / トキシコキネティクス / ファーマコキネティクス / I型薬剤 / サル / ヌードマウス / ヒト癌 / トキシコテネティクス / I型抗癌剤 / 濃度時間積 / マイトマイシンC / サイクロフォスファミド / シスプラチン / toxicokinetics / anticancer drug / type I agent / monkey / human / mouse / human neoplasm / 骨粗鬆症 / アパタイト / バイオマテリアル / 徐放化 / 人工骨 / インテリジェントマテリアル / 骨密度 / 骨粗鬆症, / 薬物送達システム, / アパタイト, / バイオマテリアル, / 徐放化, / 人工骨, / インテリジェントマテリアル, / 除放化 / Osteoporosis / apatite / biomaterials / sustained drug release / atificial bone / intelligent materials / bone mineral density / 胆汁排出 / CMOAT / 異物解毒 / 発現誘導 / GS-Xポンプ / 胆管側膜透過 / 有機アニオン輸送担体 / ABC輸送担体 / MRPファミリー / biliary excretion / detoxification / ABC transporter / organic anions / induction / GS-X pump / 強心配糖体 / ウアバイン / 心筋収縮力 / Na^+,K^+ATPase / 心臓灌流実験 / グルコース代謝 / ベンゾジアゼピンレセプター / Na^+ / K^+ATPase / Na^+,Ka^+ATPase / Cardiac glycosides / Ouabain / Positive inotropic action / Na^+,K^+ ATPase / Isolated perfused heart / Glucose metabolism / 血液脳脊髄関門 / 肝障害 / 腎障害 / 脈絡叢 / 薬物脳移行 / 腎障害ラット / イミブラミン / デシプラミン / DL-プロプラノロール / cerebrospinal fluid / choroid plexus / renal failure / hepatic failure / クロナゼパム / デオキシグルコ-ス / ゾルピデム / 代謝 / デオキシグルコース / グルコース / Benzodiazepine / clonazepam / deoxyglucose / zolpidem / metabolism / brain / 個体間変動 / 母集団薬物動態解析 / カルバマゼピン / 生理学的薬物動態モデル / 酵素誘導 / 個人間変動 / 母集団薬物動態解析法 / 有機アニオントランスポータ / CYP2C9 / アデホビル / セロトニントランスポータ / 薬学 / 臨床 / 内在性基質 / 薬物相互作用 / 生理学的薬物速度論モデル / バイオマーカー Less

トランスポーターの関わる複雑な薬物間相互作用の定量的予測法の統合的開発Principal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Josai International University
肝OATP内在性基質の体内動態メカニズム解析による生理学的薬物速度論モデルの確立
- Principal Investigator
  
  吉門崇
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Yokohama College of Pharmacy
薬物組織移行・薬効・副作用の支配要因の変動を考慮したバーチャル臨床試験系の確立Principal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Josai International University
  Institute of Physical and Chemical Research
Database for variation of pharmacokinetic and pharmacodynamic parameters in various diseases
- Principal Investigator
  
  千葉康司
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Yokohama College of Pharmacy
Development of quantitative prediction methods for alteration in pharmacokinetics caused by interindividual variability in transporter function and transporter-mediated drug-drug interactionPrincipal Investigator
- Principal Investigator
  
  Sugiyama Yuichi
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Medical pharmacy
- Research Institution
  Institute of Physical and Chemical Research
異物解毒システムの個人間変動要因に基づいた抗癌剤処方の最適化戦略の開発Principal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
薬物動態・薬効の変動に関与する薬物トランスポーターの遺伝子多型の包括的実証研究Principal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Development of probe drugs for the evaluation of the functions of drug transporters in vivo in humansPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Analysis of the function and regulatory mechanism of drug transportsome
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Development of the quantitative prediction method of pharmacokinetics with considering the function of metabolic enzymes and transportersPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
抗癌剤のテーラーメード医療確立のための異物解毒システムにおける個人差の解明
- Principal Investigator
  
  楠原洋之
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
New strategy for the drug development of CNS acting drugs by regulating drug transport across the blood-brain barrierPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
肝・腎トランスポーターによる機能分担と活性調節に関する分子シンクロナイゼーション
- Principal Investigator
  
  楠原洋之
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Drug design based on the substrate specificity of the efflux transporters expressed in the blood-brain barrierPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
Development of the system for prediction of drug-drug interactions in hepatobiliary transport processPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo
Analysis of the vectorial transport of amino acid and drugs in epithelial cells.Principal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
肝細胞膜に発現するトランスポーターの分子機能におけるシンクロナイゼーション
- Principal Investigator
  
  加藤将夫
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Metabolic activation of procarcinogens and cancer risk
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Analysis of the factors governing the elimination route of therapeutic agentsPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Graduate School of Pharmaceutical Sciences, The University of Tokyo
Role of hepatic transporters in the detoxificationPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  Graduate School of Pharmaceutical Sciences, The University of Tokyo
Development of recombinant proteins with an aim to increase their therapeutic activity by the regulation of intracellular sortingPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
胆管側膜上有機アニオン輸送担体および関連蛋白とチャンネル機能の協関Principal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
受容体介在性機構による遺伝子導入法の速度論的評価(組み換え型ウイルスベクターと非ウイルスベクターの細胞内動態の解析)
- Principal Investigator
  
  鈴木洋史
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo
アンチセンスDNAの至適投与法の確立を目指した体内動態、細胞内動態解析法の開発Principal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo
異物解毒の分子基盤:代謝・排泄能の分子から個体への予測Principal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Role of hepatic transporters in the detoxificationPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Graduate School of Pharmaceutical Sciences, The University of Tokyo
Analysis of multiplicity and polymorphism of drug transporters expressed in the liver.Principal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Analysis of molecular basis for the presence of interindividual difference in the biliary excretion of xenobiotics
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Graduate School of Pharmaceutical Sciences, The University of Tokyo
胆管側膜上有機アニオン輸送担体のクローニングとチャンネル機能の構造Principal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
薬物解毒(代謝・排泄)能力の予測:分子から個体へPrincipal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Development of a method to predict in vivo drug metabolism and excretion from in vitro data with human hepatic tissues and/or recombinant proteinsPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Graduate School of Pharmaceutical Sciences, The University of Tokyo
Endogenous signal-responsive drug release from bioactive bone cement
- Principal Investigator
  
  OTSUKA Makoto
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kobe Pharmaceutical Univesity
抗癌剤の前臨床データを基にしたヒトにおける動態、最大耐用量、抗腫瘍効果の予測Principal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Clarification of organ specific transport mechanism of druge and its application to regulation of pharmacokinetics and pharmacodynamics
- Principal Investigator
  
  TSUJI Akira
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University
Development of Pharmacokinetic and Safety Assessment of in vivo Virus Infection and Vaccine Therapy
- Principal Investigator
  
  TERASAKI Tetsuya
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tohoku University
  The University of Tokyo
A new approach for prediction of clinical efficacy of anticancer drugs based on toxicokinetic and pharmacokinetic analysis
- Principal Investigator
  
  OHNISHI Yasuyuki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
抗癌剤の最適投与計画の作成:骨髄毒性の定量化とその回避Principal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
薬物動態の分子基盤:解毒(代謝・排泄)能力の予測Principal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Prediction of hepatobiliary transport of drugs : Contribution of carrier-mediated transport in the detoxication of xenobioticsPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Faculty of Pharmaceutical Sciences, The University of Tokyo
Drug Delivery to the Brain Using Cell Adhesion Molecule
- Principal Investigator
  
  TERASAKI Tetsuya
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Department of Pharmacutics, Faculty of Pharmaceutical Sciences, University of Tokyo,
Development of drug delivery systems for cytokines with an aim of efficient exertion of their pharmacological effectPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Faculty of Pharmaceutical Sciences, University of Tokyo
チトクロームP450を利用したがん原性のシュミレーションと発がんの感受性の解析
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
Prediction and control effectiveness and safety of a drug by means of pharmacokinetics based on physiological and biochemical mechanism of its disposition in body.
- Principal Investigator
  
  HANANO Manabu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Nihon University
抗癌剤の腫瘍組織へのターゲッティングを目指した組織分布機構の速度論的解明ーP糖蛋白の関与する輸送解析ーPrincipal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
血液-脳関門における制癌剤透過機構の解明:P-糖蛋白機能発現の定量的評価
- Principal Investigator
  
  鈴木洋史
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo
A COMPREHENSIVE RESEARCH FOR EXTRAPOLATION--GENETIC HOMOLOGY BETWEEN HUMAN BEINGS AND LABORATORY ANIMALS
- Principal Investigator
  
  KASAI Noriyuki
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  TOHOKU UNIVERSITY
  Hokkaido University
Analysis of drug disposition in the central nervous system based on the transport characteristics across the blood-brain barrier and blood-cerebrospinal fluid barrier : Special focus on PeptidePrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokyo
Development of the drug delivery system for brain and cancer using the inhibitory effect of some drugs on the active efflux : Application of physiological pharmacokinetics.Principal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Tokyo
抗癌剤の腫瘍組織へのタ-ゲッティングを目指した組織分布機構の速度論的解明Principal Investigator
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
Kinetic analysis of receptor-mediated endocytosis of polypeptide hormonesPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi, HANANO Manabu
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokyo
Development of a drug delivery system using the receptors located on the cerebral microvessels : An approach based on the physiological pharmacokinetio model.Principal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi, 花野学
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokyo
Development of intracellular drug delivery system utilizing liposomes
- Principal Investigator
  
  KIWADA Hiroshi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokushima
Quantitative analysis of Pharmacological effects of psychiatic drugs using neuronal cultured cells
- Principal Investigator
  
  SAWADA Yasufumi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  University of Tokyo
Kinetic Analysis of the CNS Disposition of Drugs in the Renal and Hepatic Failure
- Principal Investigator
  
  IGA Tatsuji
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo
Quantitative relationship between in vivo receptor occupancy of psychotropic and the change of glucose utilization in brain
- Principal Investigator
  
  SAWADA Yasufumi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University
Kinetical analysis of pharmacodynamics based on drug-receptor interactions
- Principal Investigator
  
  HANANO Manabu
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokyo
Pharmacokinetic analysis of disposition of biologically active peptide in the body.Principal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University
マウスとヒトにおける抗癌剤の比較薬理学的解析
- Principal Investigator
  
  INABA Makoto
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research

[Book] Excretion systems in: "Encyclopedia of drug metabolism and interactions"2012
- Author(s)
  Maeda K, and Sugiyama Y
- Publisher
  John Wiley & Sons, Inc., New York
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Improved Prediction of the Drug-Drug Interactions of Pemafibrate Caused by Cyclosporine A and Rifampicin via PBPK Modeling: Consideration of the Albumin-Mediated Hepatic Uptake of Pemafibrate and Inhibition Constants With Preincubation Against OATP1B2021
- Author(s)
  Park Ji Eun、Shitara Yoshihisa、Lee Wooin、Morita Shigemichi、Sahi Jasminder、Toshimoto Kota、Sugiyama Yuichi
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 110 Pages: 517-528
- DOI
  10.1016/j.xphs.2020.10.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Journal Article] Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes2021
- Author(s)
  Yoshikado Takashi、Lee Wooin、Toshimoto Kota、Morita Kiyoe、Kiriake Aya、Chu Xiaoyan、Lee Nora、Kimoto Emi、Varma Manthena V.S.、Kikuchi Ryota、Scialis Renato J.、Shen Hong、Ishiguro Naoki、Lotz Ralf、Li Albert P.、Maeda Kazuya、Kusuhara Hiroyuki、Sugiyama Yuichi
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 110 Pages: 376-387
- DOI
  10.1016/j.xphs.2020.10.041
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Journal Article] Transient, Tunable Expression of NTCP and BSEP in MDCKII Cells for Kinetic Delineation of the Rate-Determining Process and Inhibitory Effects of Rifampicin in Hepatobiliary Transport of Taurocholate2021
- Author(s)
  Ito Sumito、Lee Wooin、Park Ji Eun、Yasunaga Masa、Mori Ayano、Ohtsuki Sumio、Sugiyama Yuichi
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 110 Pages: 365-375
- DOI
  10.1016/j.xphs.2020.10.064
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Journal Article] Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs2020
- Author(s)
  Lee Wooin、Koyama Satoshi、Morita Kiyoe、Kiriake Aya、Kikuchi Ryota、Chu Xiaoyan、Lee Nora、Scialis Renato J.、Shen Hong、Kimoto Emi、Tremaine Larry、Ishiguro Naoki、Lotz Ralf、Maeda Kazuya、Kusuhara Hiroyuki、Sugiyama Yuichi
- Journal Title
  
  The AAPS Journal
  
  Volume: 22 Pages: 133-133
- DOI
  10.1208/s12248-020-00512-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Journal Article] Dose‐Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs2020
- Author(s)
  Mori D, Kimoto E, Rago B, Kondo Y, King-Ahmad A, Ramanathan R, Wood LS, Johnson JG, Le VH, Vourvahis M, David Rodrigues A, Muto C, Furihata K, Sugiyama Y, Kusuhara H
- Journal Title
  
  Clinical Pharmacology & Therapeutics
  
  Volume: 107 Pages: 1004-1013
- DOI
  10.1002/cpt.1695
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100, KAKENHI-PROJECT-19H03392
[Journal Article] Comparative and quantitative assessment on statin efficacy and afety: insights into inter-statin and inter-individual variability via dose- and exposure-response relationships2019
- Author(s)
  Iwaki Y, Lee W, Sugiyama Y
- Journal Title
  
  Expert Opin Drug Metab Toxicol
  
  Volume: 15 Pages: 897-911
- DOI
  10.1080/17425255.2019.1681399
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Journal Article] Expanded Physiologically-Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction2019
- Author(s)
  Asaumi R, Menzel K, Lee W, Nunoya KI, Imawaka H, Kusuhara H, Sugiyama Y
- Journal Title
  
  CPT Pharmacometrics Syst Pharmacol
  
  Volume: 8 Pages: 845-857
- DOI
  10.1002/psp4.12457
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Journal Article] Extrapolation of In Vivo Hepatic Clearance From In Vitro Uptake Clearance by Suspended Human Hepatocytes for Anionic Drugs With High Binding to Human Albumin: Improvement of In Vitro-to-In Vivo Extrapolation by Considering the "Albumin-Mediated" Hepatic Uptake Mechanism on the Basis of the "Facilitated-Dissociation Model"2019
- Author(s)
  Kim Soo-Jin、Lee Kyeong-Ryoon、Miyauchi Seiji、Sugiyama Yuichi
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 47 Pages: 94-103
- DOI
  10.1124/dmd.118.083733
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06608, KAKENHI-PROJECT-19H03392
[Journal Article] Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine2019
- Author(s)
  Nishiyama K, Toshimoto K, Lee W, Ishiguro N, Bister B, Sugiyama Y
- Journal Title
  
  CPT Pharmacometrics Syst Pharmacol
  
  Volume: 8 Pages: 396-406
- DOI
  10.1002/psp4.12398
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Journal Article] PBPK modeling of coproporphyrin I as an endogenous biomarker for drug interactions involving inhibition of hepatic OATP1B1 and OATP1B3.2018
- Author(s)
  Yoshikado T., Toshimoto K., Maeda K., Kusuhara H., Kimoto E., Rodrigues AD., Chiba K., Sugiyama Y.
- Journal Title
  
  CPT: Pharmacometrics & Systems Pharmacology
  
  Volume: 7 Pages: 739-747
- DOI
  10.1002/psp4.12348
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08470, KAKENHI-PROJECT-17K15536, KAKENHI-PROJECT-17H04100
[Journal Article] Quantitative Analysis of Complex Drug&-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.2017
- Author(s)
  Kim SJ, Toshimoto K, Yao Y, Yoshikado T, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中
- DOI
  10.1016/j.xphs.2017.04.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches.2017
- Author(s)
  Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 24 Pages: 30084-30089
- DOI
  10.1016/j.xphs.2017.02.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data.2017
- Author(s)
  Kanamitsu K, Nozaki Y, Nagaya Y, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 32 Pages: 135-144
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Analysis of the Change in the Blood Concentration-Time Profile Caused by Complex Drug?Drug Interactions in the Liver Considering the Enterohepatic Circulation: Examining Whether the Inhibition Constants for Uptake, Metabolism, and Biliary Excretion Can be Recovered by the Analyses Using Physiologically Based Pharmacokinetic Modeling2017
- Author(s)
  Toshimoto K, Tomoda Y, Chiba K, Sugiyama Y.
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 印刷中 Pages: 2727-2738
- DOI
  10.1016/j.xphs.2017.04.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-17K08470, KAKENHI-PROJECT-16K18972
[Journal Article] Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side Effects.2017
- Author(s)
  Toshimoto K, Tomaru A, Hosokawa M, Sugiyama Y.
- Journal Title
  
  Pharm Res.
  
  Volume: 印刷中 Pages: 1584-1600
- DOI
  10.1007/s11095-017-2153-z
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-16K08378, KAKENHI-PROJECT-16K18972
[Journal Article] Estimation of Interindividual Variability of Pharmacokinetics of CYP2C9 Substrates in Humans2017
- Author(s)
  Chiba K, Shimizu K, Kato M, Miyazaki T, Nishibayashi T, Terada K, Sugiyama Y.
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 印刷中 Pages: 2695-2703
- DOI
  10.1016/j.xphs.2017.04.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-17K08470
[Journal Article] Small-dosing clinical study: Pharmacokine- tic, pharmacogeno- mics (SLCO2B1 and ABCG2), and interaction (atorvastatin and grapefruit juice) profiles of 5 probes for OATP2B1 and BCRP.2017
- Author(s)
  Kashihara Y, Ieiri I, Yoshikado T, Maeda K, Fukae M, Kimura M, Hirota T, Matsuki S, Irie S, Izumi N, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Comparison of methods for estimating unbound intracellular-to-medium concentration ratios in rat and human hepatocytes using statins.2017
- Author(s)
  Yoshikado T, Toshimoto K, Nakada T, Ikejiri K, Kusuhara H, Maeda K, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 印刷中
- DOI
  10.1124/dmd.116.074823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Preincubation- dependent and long-lasting inhibition of organic anion transporting polypeptide (OATP) and its impact on drug-drug interactions.2017
- Author(s)
  Shitara Y, and Sugiyama Y.
- Journal Title
  
  Pharmacol Ther pii:S0163-7258
  
  Volume: 17 Pages: 30066-30069
- DOI
  10.1016/j.pharmthera.2017.02.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-08022017
- Author(s)
  Ito M, Kusuhara K, Ose A, Kondo T, Tanabe K, Nakayama H, Horita S, Fujita T, Sugiyama Y.
- Journal Title
  
  AAPS Journal
  
  Volume: 19 Pages: 286-297
- DOI
  10.1208/s12248-016-9992-0
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-26293032, KAKENHI-PROJECT-26460210
[Journal Article] Possibility of Predicting Serotonin Transporter Occupancy From the In?Vitro Inhibition Constant for Serotonin Transporter, the Clinically Relevant Plasma Concentration of Unbound Drugs, and Their Profiles for Substrates of Transporters2017
- Author(s)
  Yahata Masahiro、Chiba Koji、Watanabe Takao、Sugiyama Yuichi
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 106 Pages: 2345-2356
- DOI
  10.1016/j.xphs.2017.05.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08470
[Journal Article] Prediction of inter-individual variability on the pharmacokinetics of CYP2C8 substrates in human2017
- Author(s)
  Haraya Kenta、Kato Motohiro、Chiba Koji、Sugiyama Yuichi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 32 Issue: 6 Pages: 277-285
- DOI
  10.1016/j.dmpk.2017.09.001
- NAID
  210000165497
- ISSN
  1347-4367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08470
[Journal Article] Is Ethnic Variability in the Exposure to Rosuvastatin Explained Only by Genetic Polymorphisms in OATP1B1 and BCRP or Should the Contribution of Intrinsic Ethnic Differences in OATP1B1 Be Considered?2017
- Author(s)
  Sugiyama Y, Maeda K, Toshimoto K.
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中 Pages: 2227-2230
- DOI
  10.1016/j.xphs.2017.04.074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-16K18972
[Journal Article] Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments.2016
- Author(s)
  Kanamitsu K, Arakawa R, Sugiyama Y, Suhara T, Kusuhara H.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 31 Pages: 395-404
- NAID
  50014448705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method.2016
- Author(s)
  Yoshikado T, Yoshida K, Kotani N, Nakada T, Asaumi R, Toshimoto K. Maeda K, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: 100 Pages: 513-523
- DOI
  10.1002/cpt.391
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs2016
- Author(s)
  Hayakawa Y, Kawada M, Nishikawa H, Ochiya T, Saya H, Seimiya H, Yao Y, Hayashi M, Kai C, Matsuda A, Naoe T, Ohtsu A, Okazaki T, Saji H, Sata M, Sugimura H, Sugiyama Y, Toi M, Irimura T
- Journal Title
  
  Cancer Sci.
  
  Volume: 107(2) Pages: 189-202
- DOI
  10.1111/cas.12857
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670023, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25293011, KAKENHI-PROJECT-25293184, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-15K06888, KAKENHI-PROJECT-16K15551, KAKENHI-PROJECT-26290054
[Journal Article] Prediction of inter-individual variability on the pharmacokinetics of CYP1A2 substrates in non-smoking healthy volunteers2016
- Author(s)
  Haraya K, Kato M, Chiba K, Sugiyama Y.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 31 Issue: 4 Pages: 276-284
- DOI
  10.1016/j.dmpk.2016.03.003
- NAID
  50014448692
- ISSN
  1347-4367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 to Develop Sensitive Fluorescence-Based Oatp1B1 Inhibition Assays.2016
- Author(s)
  Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Mol Pharm
  
  Volume: 13 Pages: 438-448
- DOI
  10.1021/acs.molpharmaceut.5b00664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Radiosynthesis of novel pitavastatin derivative ([18F]PT V-F1) as a tracer for hepatic OATP using a one-pot synthetic procedure. J Labelled Comp Radiopharm2016
- Author(s)
  Kimura H, Yagi Y, Arimitsu K, Maeda K, Ikejiri K, Takano J, Kusuhara H, Kagawa S, Ono M, Sugiyama Y, Saji H.
- Journal Title
  
  J Labelled Comp Radiopharm.
  
  Volume: 59 Pages: 565-575
- DOI
  10.1002/jlcr.3464
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-26461816
[Journal Article] Usefulness of a Model-Based Approach for Estimating in Vitro P-Glycoprotein Inhibition Potency in a Transcellular Transport Assay.2016
- Author(s)
  Kishimoto W, Ishiguro N, Ludwig- Schwellinger E, Ebner T, Maeda K, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 105 Pages: 891-896
- DOI
  10.1016/j.xphs.2015.11.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] The Prediction of the Relative Importance of Cyp3a/P-Glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model.2016
- Author(s)
  Takano J, Maeda K, Bolger MB, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 44 Pages: 1808-1818
- DOI
  10.1124/dmd.116.070011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure.2016
- Author(s)
  Ose A, Toshimoto K, Ikeda K, Maeda K, Yoshida S, Yamashita F, Hashida M, Ishida T, Akiyama Y, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 105 Pages: 2222-2230
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Clarification of the Mechanism of Clopidogrel- Mediated Drug-Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information.2016
- Author(s)
  Kim SJ, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 44 Pages: 1622-1632
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Explication of Definitional Description and Empirical Use of Fraction of Orally Administered Drugs Absorbed From the Intestine (Fa) and Intestinal Availability (Fg): Effect of P-glycoprotein and CYP3A on Fa and Fg.2016
- Author(s)
  Tanaka Y, Kitamura Y, Maeda K, Sugiyama Y.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 105 Pages: 431-442
- DOI
  10.1016/j.xphs.2015.11.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Investigation of Endogenous Compounds Applicable to Drug - Drug Interaction Studies Involving the Renal Organic Anion Transporters, Oat1 and Oat3, in Humans.2016
- Author(s)
  Tsuruya Y, Kato K, Sano Y, Imamura Y, Maeda K, Kumagai Y, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 44 Pages: 1925-1933
- DOI
  10.1124/dmd.116.071472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Microdosing and Other Phase 0 Clinical Trials: Facilitating Translation in Drug Development.2016
- Author(s)
  Burt T, Yoshida K, Lappin G, Vuong L, John C, de Wildt SN, Sugiyama Y, Rowland M.
- Journal Title
  
  Clin Transl Sci
  
  Volume: 9 Pages: 74-88
- DOI
  10.1111/cts.12390
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Involvement of Organic Cation Transporters in the Clearance and Milk Secretion of Thiamine in Mice.2015
- Author(s)
  Kato K, Moriyama C, Ito N, Zhang X, Hachiuma K, Hagima N, Iwata K, Yamaguchi J, Maeda K, Ito K, Suzuki H, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Pharm Res
  
  Volume: 32 Pages: 2192-2204
- DOI
  10.1007/s11095-014-1608-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Quantitative Analysis of the Abcg2 C.421c>a Polymorphism Effect on in Vivo Transport Activity of Breast Cancer Resistance Protein (Bcrp) Using an Intestinal Absorption Model.2015
- Author(s)
  Tanaka Y, Kitamura Y, Maeda K, Sugiyama Y
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中 Pages: 3093-3048
- DOI
  10.1002/jps.24366
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24689009, KAKENHI-PROJECT-24229002
[Journal Article] A clinical pharmacokinetic microdosing study of docetaxel with Japanese patients with cancer.2015
- Author(s)
  Fujita K, Yoshino E, Kawara K, Maeda K, Kusuhara H, Sugiyama Y, Yokoyama T, Kaneta T, Ishida H, Sasaki Y.
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 76 Pages: 793-801
- DOI
  10.1007/s00280-015-2844-2
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Use of a Physiologically Based Pharmacokinetic Model for Quantitative Prediction of Drug-Drug Interactions Via Cyp3a4 and Estimation of the Intestinal Availability of Cyp3a4 Substrates.2015
- Author(s)
  Y. Mano, Y. Sugiyama, K. Ito
- Journal Title
  
  J Pharm Sci
  
  Volume: 104 Pages: 3183-3193
- DOI
  10.1002/jps.24495
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460209, KAKENHI-PROJECT-24229002
[Journal Article] Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C] Metformin in Mouse.2015
- Author(s)
  Shingaki T, Hume WE, Takashima T, Katayama Y, Okauchi T, Hayashinaka E, Wada Y, Cui Y, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  Pharm Res
  
  Volume: 32 Pages: 2538-2547
- DOI
  10.1007/s11095-015-1642-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Effects of Cremophor El on the Absorption of Orally Administered Saquinavir and Fexofenadine in Healthy Subjects.2015
- Author(s)
  Tomaru A, Takeda-Morishita M, Maeda K, Banba H, Takayama K, Kumagai Y, Kusuhara H, Sugiyama Y
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 印刷中 Issue: 3 Pages: 221-226
- DOI
  10.1016/j.dmpk.2015.01.002
- NAID
  50014429954
- ISSN
  1347-4367
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24689009, KAKENHI-PROJECT-24229002
[Journal Article] The synthesis of [18F] pitavastatin as a tracer for hOATP using the Suzuki coupling.2015
- Author(s)
  Y. Yagi, H. Kimura, K. Arimitsu, M. Ono, K. Maeda, H. Kusuhara, T. Kajimoto, Y. Sugiyama, H. Saji
- Journal Title
  
  Org Biomol Chem
  
  Volume: 13 Pages: 1113-1121
- DOI
  10.1039/c4ob01953a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460022, KAKENHI-PROJECT-24229002
[Journal Article] An Assessment of the Oral Bioavailability of Three Ca-Channel Blockers Using a Cassette-Microdose Study: A New Strategy for Streamlining Oral Drug Development.2015
- Author(s)
  Yamashita M, Kataoka Y, Suzaki H, Imai T, Morimoto K, Ohashi A, Inano K, Togashi K, Mutaguchi K, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 104 Pages: 3154-3161
- DOI
  10.1002/jps.24499
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration.2015
- Author(s)
  Liu H, Yu N, Lu S, Ito S, Zhang X, Prasad B, He E, Lu X, Li Y, Wang F, Xu H, An G, Unadkat JD, Kusuhara H, Sugiyama Y, Sahi J.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 43 Pages: 1008-1018
- DOI
  10.1124/dmd.115.064170
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293032, KAKENHI-PROJECT-24229002
[Journal Article] Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug Interactions.2015
- Author(s)
  Izumi S, Nozaki Y, Maeda K, Komori T, Takenaka O, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 43 Pages: 235-247
- DOI
  10.1124/dmd.114.059105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans2014
- Author(s)
  Maeda K, Tian Y, Fujita T, Ikeda Y, Kumagai Y, Kondo T, Tanabe K, Nakayama H, Horita S, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Eur J Pharm Sci
  
  Volume: - Pages: 94-103
- DOI
  10.1016/j.ejps.2014.04.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23590646, KAKENHI-PROJECT-24229002
[Journal Article] Quantitative investigation of the brain-to-cerebrospinal fluid unbound drug concentration ratio under steady-state conditions in rats using a pharmacokinetic model and scaling factors for active efflux transporters.2014
- Author(s)
  Kodaira H, Kusuhara H, Fuse E, Ushiki J, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 42 Pages: 983-9
- DOI
  10.1124/dmd.113.056606
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002
[Journal Article] Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins.2014
- Author(s)
  Kato K, Mori H, Kito T, Yokochi M, Ito S, Inoue K, Yonezawa A, Katsura T, Kumagai Y, Yuasa H, Moriyama Y, Inui K, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Pharm Res.
  
  Volume: 31 Pages: 136-147
- DOI
  10.1007/s11095-013-1144-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390138, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-25670074
[Journal Article] Prediction of inter-individual variability in the pharmacokinetics of CYP2C19 substrates in humans.2014
- Author(s)
  Chiba K, Shimizu K, Kato M, Nishibayashi T, Terada K, Izumo N and Sugiyama Y.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 29 Pages: 379-86
- NAID
  130004463402
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Differential Roles of Ubiquitination in the Degradation Mechanism of Cell Surface-resident BSEP and MRP2.2014
- Author(s)
  Aida K, Hayashi H, Inamura K, Mizuno T, Sugiyama Y
- Journal Title
  
  Mol Pharmacol
  
  Volume: Vol85, No.3 Pages: 482-491
- DOI
  10.1124/mol.113.091090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J11195, KAKENHI-PROJECT-24229002
[Journal Article] 6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects.2014
- Author(s)
  Imamura Y, Tsuruya Y, Damme K, Heer D, Kumagai Y, Maeda K, Murayama N, Okudaira N, Kurihara A, Izumi T, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 42 Pages: 685-694
- DOI
  10.1124/dmd.113.055475
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659071
[Journal Article] A Proposal of a Pharmacokinetic/pharmacodynamic (PK/PD) Index Map for Selecting an Optimal PK/PD Index from Conventional Indices (AUC/MIC, C<sub>max</sub>/MIC, and TAM) for Antibiotics2014
- Author(s)
  Kitamura Y, Yoshida K, Kusama M and Sugiyama Y.
- Journal Title
  
  DMPK
  
  Volume: 29 Issue: 6 Pages: 455-462
- DOI
  10.2133/dmpk.dmpk-14-rg-013
  10.2133/dmpk.DMPK-14-RG-013
- NAID
  130004933551
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Investigation of the effect of active efflux at the blood-brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system.2013
- Author(s)
  Miyajima M, Kusuhara H, Takahashi K, Takashima T, Hosoya T, Watanabe Y, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Pages: 3309-3319
- DOI
  10.1002/jps.23600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002
[Journal Article] Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes.2013
- Author(s)
  Kudo T, Hisaka A, Sugiyama Y, Ito K.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 41 Pages: 362-371
- DOI
  10.1124/dmd.112.049460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590204, KAKENHI-PROJECT-24229002
[Journal Article] Investigation of the effect of the uneven distribution of CYP3A4 and P-glycoprotein in the intestine on the barrier function against xenobiotics: a simulation study.2013
- Author(s)
  Watanabe T, Maeda K, Nakai C and Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Pages: 3196-3204
- DOI
  10.1002/jps.23623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24689009
[Journal Article] Factors associated with spontaneous reporting of adverse drug reactions in Japan.2013
- Author(s)
  Yamada T, et al.
- Journal Title
  
  Pharmacoepidemiol Drug Saf
  
  Volume: 22 Pages: 468-476
- DOI
  10.1002/pds.3378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590100, KAKENHI-PROJECT-21790109, KAKENHI-PROJECT-24229002
[Journal Article] Effect of the fluoroquinolone antibacterial agent DX-619 on the apparent formation and renal clearances of 6beta-hydroxycortisol, an endogenous probe for CYP3A4 inhibition, in healthy subjects.2013
- Author(s)
  Imamura Y, Murayama N, Okudaira N, Kurihara A, Inoue K, Yuasa H, Izumi T, Kusuhara H and Sugiyama Y.
- Journal Title
  
  Pharm Res
  
  Volume: 30 Pages: 447-457
- DOI
  10.1007/s11095-012-0890-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203.2013
- Author(s)
  Toyoshima J, Kusuhara H, Wempe MF, Endou H, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Pages: 3228-3238
- DOI
  10.1002/jps.23601
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002
[Journal Article] Transporter biology in drug approval: regulatory aspects.2013
- Author(s)
  Maeda K and Sugiyama Y.
- Journal Title
  
  Mol Aspects Med
  
  Volume: 34 Pages: 711-718
- DOI
  10.1016/j.mam.2012.10.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion using Newly Developed Positron Emission Tomography (PET) Tracer, [11C]Dehydropravastatin, in Rats2013
- Author(s)
  Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui Y, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: 347 Pages: 193-202
- DOI
  10.1124/jpet.113.206425
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659574, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam (CYP3A4), fexofenadine (p-glycoprotein), and pravastatin (OATP1B1) as probe drugs.2013
- Author(s)
  Ieiri I, Tsunemitsu S, Maeda K, Ando Y, Izumi N, Kimura M, Yamane N, Okuzono T, Morishita M, Kotani N, Kanda E, Deguchi M, Matsuguma K, Matsuki S, Hirota T, Irie S, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Clin Pharmacol
  
  Volume: 53 Pages: 1-16
- DOI
  10.1002/jcph.62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24689009
[Journal Article] Studies on the intestinal absorption characteristics of sulfasalazine, a breast cancer resistance protein (BCRP) substrate.2013
- Author(s)
  Tomaru A, Morimoto N, Morishita M, Takayama K, Fujita T, Maeda K, Kusuhara H and Sugiyama Y.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 28 Pages: 71-74
- NAID
  130004463289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Microdose pharmacogenetic study of (1)(4)C-tolbutamide in healthy subjects with accelerator mass spectrometry to examine the effects of CYP2C9 *3 on its pharmacokinetics and metabolism.2013
- Author(s)
  Ikeda T, Aoyama S, Tozuka Z, Nozawa K, Hamabe Y, Matsui T, Kainuma M, Hasegawa S, Maeda K and Sugiyama Y.
- Journal Title
  
  Eur J Pharm Sci
  
  Volume: 49 Pages: 642-648
- DOI
  10.1016/j.ejps.2013.05.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Substrate-dependent inhibition of organic anion transporting polypeptide 1B1: comparative analysis with prototypical probe substrates estradiol-17beta-glucuronide, estrone-3-sulfate, and sulfobromophthalein.2013
- Author(s)
  Izumi S, Nozaki Y, Komori T, Maeda K, Takenaka O, Kusano K, Yoshimura T, Kusuhara H and Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 41 Pages: 1859-1866
- DOI
  10.1124/dmd.113.052290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Effect of coadministration of single and multiple doses of rifampicin on the pharmacokinetics of fexofenadine enantiomers in healthy subjects.2013
- Author(s)
  Kusuhara H
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 41 Pages: 206-13
- DOI
  10.1124/dmd.112.048330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002, KAKENHI-PLANNED-23136101
[Journal Article] Hepatic and intestinal drug transporters: prediction of pharmacokinetic effects caused by drug-drug interactions and genetic polymorphisms.2013
- Author(s)
  Yoshida K, Maeda K and Sugiyama Y
- Journal Title
  
  Annu Rev Pharmacol Toxicol
  
  Volume: 53 Pages: 581-612
- DOI
  10.1146/annurev-pharmtox-011112-140309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J09907, KAKENHI-PROJECT-24229002, KAKENHI-PLANNED-23136101
[Journal Article] Evaluation of Bcrp Function in Hepatobiliary and Renal Excretion using PET with [11C]SC-628072013
- Author(s)
  Takashima T, Wu C, Takashima-Hirano M, Katayama Y, Wada Y, Suzuki M, Kusuhara H, Sugiyama Y and Watanabe Y.
- Journal Title
  
  J Nucl Med.
  
  Volume: 54 Pages: 267-276
- DOI
  10.2967/jnumed.112.110254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-25242070, KAKENHI-PLANNED-23136101
[Journal Article] Relationship between the urinary excretion mechanisms of drugs and their physicochemical properties.2013
- Author(s)
  Ito S, Ando H, Ose A, Kitamura Y, Ando T, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Pages: 3294-3301
- DOI
  10.1002/jps.23599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002
[Journal Article] Epigenetic Regulation of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines.2013
- Author(s)
  Imai S, Kikuchi R, Tsuruya Y, Naoi S, Nishida S, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Pharm Res
  
  Volume: 30 Pages: 2880-2890
- DOI
  10.1007/s11095-013-1117-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J10600, KAKENHI-PROJECT-13J08293, KAKENHI-PROJECT-24229002
[Journal Article] Cost-effectiveness analysis of microdose clinical trials in drug development.2013
- Author(s)
  Yamane N, Igarashi A, Kusama M, Maeda K, Ikeda T and Sugiyama Y.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 28 Pages: 187-195
- NAID
  130004463302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] DNA methylation and histone modification profiles of mouse organic anion transporting polypeptides.2013
- Author(s)
  Imai S.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 41 Pages: 72-78
- DOI
  10.1124/dmd.112.047969
- NAID
  130004639789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002
[Journal Article] Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: Therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development.2013
- Author(s)
  Takahara N, Saga T, Inubushi M, Kusuhara H, Seki C, Ito S, Oyama N, Yokoyama O, Sugiyama Y, Fujibayashi Y.
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 40 Pages: 643-650
- DOI
  10.1016/j.nucmedbio.2013.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390239, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659140, KAKENHI-PROJECT-24659559
[Journal Article] The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo.2013
- Author(s)
  Hume WE, Shingaki T, Takashima T, Hashizume Y, Okauchi T, Katayama Y, Hayashinaka E, Wada Y, Kusuhara H, Sugiyama Y and Watanabe Y.
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 21 Pages: 7584-7590
- DOI
  10.1016/j.bmc.2013.10.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption.2013
- Author(s)
  Shitara Y, Maeda K, Ikejiri K, Yoshida K, Horie T, Sugiyama Y
- Journal Title
  
  Biopharm Drug Dispos
  
  Volume: 34 Pages: 45-78
- DOI
  10.1002/bdd.1823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J09907, KAKENHI-PROJECT-24229002, KAKENHI-PLANNED-23136101
[Journal Article] Direct and rapid genotyping of SLCO1B1 388A>G and 521T>C in human blood specimens using the SmartAmp-2 method.2013
- Author(s)
  Yoshida K, Takano J, Ishizu Y, Lezhava A, Ieiri I, Maeda K, Hayashizaki Y and Sugiyama Y.
- Journal Title
  
  AAPS J
  
  Volume: 15 Pages: 618-622
- DOI
  10.1208/s12248-013-9471-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure.2012
- Author(s)
  Endo S, Fukahori A, Tokuhiro S, Shinagawa A, Walker J, Yoshihara K, Ishizuka H, Ieiri I, Sugiyama Y.
- Journal Title
  
  J Hum Genet
  
  Volume: 57 Pages: 531-44
- DOI
  10.1038/jhg.2012.63
- NAID
  10031056697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- and OATP1B3-mediated uptake.2012
- Author(s)
  Shitara Y, Takeuchi K, Nagamatsu Y, Wada S, Sugiyama Y, Horie T.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 27 Pages: 368-78
- NAID
  130004463264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] PET imaging-based evaluation of hepatobiliary transport in humans with (15R)-11C-TIC-Me.2012
- Author(s)
  Tadayuki Takashima, Satoshi Kitamura, Yasuhiro Wada, Masaaki Tanaka, Yoshihito Shigihara, Hideki Ishii, Ryosuke Ijuin, Susumu Shiomi, Takahiro Nakae, Yumiko Watanabe, Yilong Cui, Hisashi Doi, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
- Journal Title
  
  J Nucl Med
  
  Volume: 53 Pages: 741-748
- DOI
  10.2967/jnumed.111.098681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790121, KAKENHI-PROJECT-23300241, KAKENHI-PROJECT-24229002
[Journal Article] Prediction of nonlinear intestinal absorption of CYP3A4 and P-glycoprotein substrates from their in vitro Km values.2012
- Author(s)
  Tachibana T, Kato M, Sugiyama Y.
- Journal Title
  
  Pharm Res
  
  Volume: 29 Pages: 651-68
- DOI
  10.1007/s11095-011-0579-2
- NAID
  130004639845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Regulation of Tissue-Specific Expression of Renal Organic Anion Transporters by Hepatocyte Nuclear Factor 1 alpha/beta and DNA Methylation2012
- Author(s)
  Jin L、Kikuchi R、Saji T、Kusuhara H、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 340巻 Pages: 648-655
- DOI
  10.1124/jpet.111.187161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] 薬物の効果・副作用におよぼす肝トランスポーターの役割-薬物間相互作用、遺伝子多型を中心に2012
- Author(s)
  杉山雄一
- Journal Title
  
  薬理と治療
  
  Volume: 33 Pages: 939-945
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Pharmacokinetic interaction study of sulfasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP.2012
- Author(s)
  Kusuhara H, et al
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: (In press) Pages: 1793-1803
- DOI
  10.1111/j.1476-5381.2012.01887.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-23590206, KAKENHI-PROJECT-24229002
[Journal Article] Prediction of the degree of transporter-mediated drug-drug interactions involving OATP substrates based on in vitro inhibition studies2012
- Author(s)
  Kenta Yoshida, Kazuya Maeda, Yuichi Sugiyama
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Association of multidrug resistance-associated protein 2 single nucleotide polymorphism rs12762549 with the basal plasma levels of phase II metabolites of isoflavonoids in healthy Japanese individuals.2012
- Author(s)
  Kato K, et al
- Journal Title
  
  Pharmacogenet Genomics
  
  Volume: 22 Pages: 344-354
- DOI
  10.1097/fpc.0b013e3283517012
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002
[Journal Article] Dynamic analysis of GI absorption and hepatic distribution processes of telmisartan in rats using positron emission tomography.2012
- Author(s)
  Kataoka M, Takashima T, Shingaki T, Hashidzume Y, Katayama Y, Wada Y, Oh H, Masaoka Y, Sakuma S, Sugiyama Y, Yamashita S, Watanabe Y.
- Journal Title
  
  Pharm Res
  
  Volume: 29 Pages: 2419-31
- DOI
  10.1007/s11095-012-0768-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.2012
- Author(s)
  Ito S、Kusuhara H、Yokochi M、ToyoshimaJ、Inoue K、Yuasa H、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 340巻 Pages: 393-403
- DOI
  10.1124/jpet.111.184986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008, KAKENHI-PROJECT-24229002
[Journal Article] Pharmacogenomic/pharmacokinetic assessment of a four-probe cocktail for CYPs and OATPs following oral microdosing.2012
- Author(s)
  Ieiri I, Fukae M, Maeda K, Ando Y, Kimura M, Hirota T, Nakamura T, Iwasaki K, Matsuki S, Matsuguma K, Kanda E, Deguchi M, Irie S, Sugiyama Y.
- Journal Title
  
  Int J Clin Pharmacol Ther
  
  Volume: 50 Pages: 689-700
- DOI
  10.5414/cp201763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Synthesis of [(11)C]dehydropravastatin, a PET probe potentially useful for studying OATP1B1 and MRP2 transporters in the liver.2012
- Author(s)
  Ryosuke Ijuin, Tadayuki Takashima, Yasuyoshi Watanabe, Yuichi Sugiyama and Masaaki Suzuki
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 20 Pages: 3703-3709
- DOI
  10.1016/j.bmc.2012.04.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790121, KAKENHI-PROJECT-24229002
[Journal Article] Prediction of the degree oftransporter-mediated drug-drug interactions involving OATP substrates based on in vitro inhibition studies、2012
- Author(s)
  Yoshida K、Maeda K、Sugiyama Y
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes.2012
- Author(s)
  Nakakariya M, Ono M, Amano N, Moriwaki T, Maeda K, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 40 Pages: 602-9
- DOI
  10.1124/dmd.111.042101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Microdosing clinical study: pharmacokinetic, pharmacogenomic (SLCO2B1), and interaction (grapefruit Juice) profiles of celiprolol following the oral microdose and therapeutic dose.2012
- Author(s)
  Ieiri I, Doi Y, Maeda K, Sasaki T, Kimura M, Hirota T, Chiyoda T, Miyagawa M, Irie S, Iwasaki K, Sugiyama Y.
- Journal Title
  
  J Clin Pharmacol
  
  Volume: 52 Pages: 1078-89
- DOI
  10.1177/0091270011408612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] 薬物の効果・副作用におよぼす肝トランスポーターの役割2012
- Author(s)
  杉山雄一
- Journal Title
  
  薬物間相互作用、遺伝子多型を中心に、薬理と治療
  
  Volume: 33巻 Pages: 939-945
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Whole-body distribution and radiation dosimetry of [11C]telmisartan as a biomarker for hepatic organic anion transporting polypeptide (OATP) 1B3.2012
- Author(s)
  Shimizu K, Takashima T, Yamane T, Sasaki M, Kageyama H, Hashizume Y, Maeda K, Sugiyama Y, Watanabe Y, Senda M.
- Journal Title
  
  Nucl Med Biol
  
  Volume: 39 Pages: 847-53
- DOI
  10.1016/j.nucmedbio.2012.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving OAT3 in humans by in vitro uptake experiments.2011
- Author(s)
  Watanabe T, Kusuhara H, Watanabe T, Debori Y, Maeda K, Kondo T, Nakayama H, Horita S, Ogilvie BW, Parkinson A, Hu Z, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos in press
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Prediction of fluoroquinolone-induced elevation in serum creatinine levels : a caseof drug-endogenous substance interaction involving the inhibition of renal secretion2011
- Author(s)
  Imamura Y、Murayama N、Okudaira N、Kurihara A、Okazaki O、Izumi T、Inoue K、Yuasa H、Kusuhara H、Sugiyama Y
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: 89巻 Pages: 81-88
- DOI
  10.1038/clpt.2010.232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans byIn Vitro Uptake Experiments2011
- Author(s)
  Watanabe T、Kusuhara H、Watanabe T、Debori Y、Maeda K、Kondo T、NakayamaH、Horita S、Ogilvie BW、Parkinson A、Hu Z、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 39巻 Pages: 1031-1038
- DOI
  10.1124/dmd.110.036129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes2011
- Author(s)
  Kotani N、Maeda K、Watanabe T、HiramatsuM、Gong L-K、Bi Y-A、Takezawa T、Kusuhara H、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 39巻 Pages: 1503-1510
- DOI
  10.1124/dmd.111.038968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving OAT3 in humans by in vitro uptake experiments.2011
- Author(s)
  Watanabe T, Kusuhara H, Watanabe T, Debori Y, Maeda K, Kondo T, Nakayama H, Horita S, Ogilvie BW, Parkinson A, Hu Z, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Organic Anion Transporter 3 Mediates the Efflux Transport of an Amphipathic Organic Anion, Dehydroepiandrosterone Sulfate, across the Blood-Brain Barrier in Mice2011
- Author(s)
  Miyajima M、Kusuhara H、Fujishima M、Adachi Y、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 39巻 Pages: 814-819
- DOI
  10.1124/dmd.110.036863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Prediction of fluoroquinolone-induced elevation in serum creatinine levels : a case of drug-endogenous substance interaction involving the inhibition of renal secretion.2011
- Author(s)
  Imamura Y, Murayama N, Okudaira N, Kurihara A, Okazaki O, Izumi T, Inoue K, Yuasa H, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: 89 Pages: 81-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Quantitative evaluation of the impact of active efflux byp-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate2011
- Author(s)
  Kodaira H、Kusuhara H、Fujita T、Ushiki J、Fuse E、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 339巻 Pages: 935-944
- DOI
  10.1124/jpet.111.180398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Kinetic Analysis of the Cooperation of P-glycoprotein(P-gp/Abcb1) and Breast Cancer Resistance Protein(Bcrp/Abcg2) in Limiting the Brainand Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone2010
- Author(s)
  Kodaira H、Kusuhara H、Ushiki J、Fuse E、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 333巻 Pages: 788-796
- DOI
  10.1124/dmd.110.034652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Predicting drug-drug interactions involving the inhibition of intestinal CYP3A4 and P-glycoprotein2010
- Author(s)
  Tachibana T、Kato M、Takano J、SugiyamaY
- Journal Title
  
  Curr Drug Metab
  
  Volume: 11巻 Pages: 762-777
- DOI
  10.2174/138920010794328922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Direct and rapid genotyping of glutathione-S-transferase M1 and T1 from human blood specimens using the SmartAmp2 method.2010
- Author(s)
  Okada R, Ishizu Y, Endo R, Lezhava A, Ieiri I, Kusuhara H, Sugiyama Y, Hayashizaki Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 38 Pages: 1636-1639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Positron emission tomography studies using(15R)-16-m-[ 11C] tolyl-17, 18, 19, 20-tetranor isocarbacyclin methyl ester for theevaluation of hepatobiliary transport2010
- Author(s)
  Watanabe T、Kusuhara H、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 37巻 Pages: 314-323
- DOI
  10.1007/s10928-010-9176-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] DNA Methylation Profiles of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines2010
- Author(s)
  Ichihara S, Kikuchi R, Kusuhara H, Imai S, Maeda K, Sugiyama Y.
- Journal Title
  
  Pharm Res 27(3)
  
  Pages: 510-516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Kinetic Analysis of the Cooperation of P-glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone2010
- Author(s)
  Hiroshi Kodaira, Hiroyuki Kusuhara, Junko Ushiki, Eiichi Fuse, Yuichi Sugiyama
- Journal Title
  
  J Pharmacol Exp Ther (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Positron emission tomography studies using (15R)-16-m-[11C]tolyl-17,18,19,20-tetra norisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.2010
- Author(s)
  Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  J Pharmacol Exp Ther 335
  
  Pages: 314-323
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters2010
- Author(s)
  Kusuhara H、Sugiyama Y
- Journal Title
  
  Drug Metab Rev
  
  Volume: 42巻 Pages: 539-550
- DOI
  10.1124/jpet.109.162321
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3(Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse2010
- Author(s)
  Kitamura Y、Kusuhara H、Sugiyama Y
- Journal Title
  
  Pharm Res
  
  Volume: 27巻 Pages: 665-672
- DOI
  10.1007/s11095-009-0047-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans.2010
- Author(s)
  Watanabe T, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Pharmacokinet Pharmacodyn
  
  Volume: 37 Pages: 575-590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] The use of hepatocytes to investigate drug uptake transporters.2010
- Author(s)
  Maeda K., Sugiyama Y
- Journal Title
  
  Methods Mol Biol
  
  Volume: 640 Pages: 327-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Direct and rapid genotyping of glutathione-S-transferase M1 and T1 from human blood specimens using the SmartAmp2 method2010
- Author(s)
  Okada R、Ishizu Y、Endo R、Lezhava A、Ieiri I、Kusuhara H、Sugiyama Y、Hayashizaki Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 38巻 Pages: 1636-1639
- DOI
  10.1124/jpet.110.170092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier2010
- Author(s)
  Ose A、Kusuhara H、Endo C、Tohyama K、Miyajima M、Kitamura S、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 38巻 Pages: 168-76
- DOI
  10.1124/jpet.109.156943
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.2010
- Author(s)
  Ose A, Kusuhara H, Endo C, Tohyama K, Miyajima M, Kitamura S, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos 38(1)
  
  Pages: 168-176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] The use of hepatocytes to investigate drug uptake transporters2010
- Author(s)
  Maeda K、Sugiyama Y
- Journal Title
  
  Methods Mol Biol
  
  Volume: 640巻 Pages: 327-353
- DOI
  10.1007/978-1-60761-688-7_18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Functional Characterization of Multidrug Resistance-Associated Protein 3(Mrp3/Abcc3) in the Basolateral Efflux of Glucuronide Conjugates in the Mouse Small Intestine2010
- Author(s)
  Kitamura Y、Kusuhara H、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 332巻 Pages: 659-666
- DOI
  10.1007/s11095-010-0064-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Functional Characterization of Multidrug Resistance-Associated Proten 3 (Mrp3/Abcc3) in the Basolateral Efflux of Glucuronide Conjugates in the Mouse Small Intestine2010
- Author(s)
  Yoshiaki Kitamura, Hiroyuki Kusuhara, Yuichi Sugiyama
- Journal Title
  
  J Pharmacol Exp Ther 332
  
  Pages: 659-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Positron emission tomography studies using(15R)-16-m-[11C]tolyl-17,18,19,20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.2010
- Author(s)
  Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 335 Pages: 314-323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse2010
- Author(s)
  Kitamura Y, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Pharm Res 27(4)
  
  Pages: 665-672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters.2010
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  Drug Metab Rev (In press)
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Predicting drug-drug interactions involving the inhibition of intestinal CYP3A4 and P-glycoprotein.2010
- Author(s)
  Tachibana T, Kato M, Takano J, Sugiyama Y
- Journal Title
  
  Curr Drug Metab
  
  Volume: 11 Pages: 762-777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Quantitative population pharmacokinetic analysis of pravastatin using an enterohepatic circulation model combined with pharmacogenomic Information on SLCO1B1 and ABCC2 polymorphisms2009
- Author(s)
  Ide, T., Sasaki, T., Maeda, K., Higuchi, S., Sugiyama, Y., Ieiri, I.
- Journal Title
  
  J Clin Pharmacol 49
  
  Pages: 1309-1317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] Interindividual pharmacokinetics variability of the alpha(4) beta(1) integrin antagonist, 4-[ 1-[ 3-chloro-4-[ N'-(2-methylphenyl) ureido] phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2-yl] methoxybenzoic acid(D01-4582), inbeagles is associated with albumin2009
- Author(s)
  Ito T、Takahashi M、Sudo K、Sugiyama Y
- Journal Title
  
  J Pharm Sci
  
  Volume: 98巻 Pages: 1545-1555
- DOI
  10.1124/jpet.108.148411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Interindividual pharmacokinetics variability of the alpha(4) beta(1) integrin antagonist,4-[1-[3-chloro-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2?yl] methoxybenzoic acid (D01-4582), in beagles is associated with albumin genetic polymorphisms.2009
- Author(s)
  Ito T, Takahashi M, Sudo K, Sugiyama Y.
- Journal Title
  
  J Pharm Sci. 98
  
  Pages: 1545-1555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Construction of triple-transfected cells[ organic anion-transporting polypeptide(OATP) 1B1/multidrugresistance-associated protein(MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP42009
- Author(s)
  Hirouchi M、Kusuhara H、Onuki R、OgilvieBW、Parkinson A、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 37巻 Pages: 2103-2111
- DOI
  10.1124/dmd.109.029454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] 薬物動態関連遺伝子変異と臨床薬理2009
- Author(s)
  山田哲裕、前田和哉、杉山雄一
- Journal Title
  
  治療学 43(3)
  
  Pages: 28-39
- NAID
  10018117709
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] Prediction of the Effects of Genetic Polymorphism on the Pharmacokinetics of CYP2C9 Substrates from In Vitro Data.2009
- Author(s)
  Kusama M, Maeda K, Chiba K, Aoyama A, Sugiyama Y.
- Journal Title
  
  Pharm Res. 26
  
  Pages: 822-835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] The 8th and 9th transmembrane domains in organic anion trans porting polypeptide (OATP) 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17{beta}-?D-glucuronide.2009
- Author(s)
  Miyagawa M, Maeda K, Aoyama A, Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.2009
- Author(s)
  Matsushima S, Maeda K, Inoue K, Ohta KY, Yuasa H, Kondo T, Nakayama H, Horita S, Kusuhara H, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 37
  
  Pages: 555-559
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Physiologically Based Pharmacokinetic Modeling to Predict Transporter-mediated Clearance and Distribution of Pravastatin in Humans2009
- Author(s)
  Watanabe, T., Kusuhara, H., Maeda, K., Shitara, Y. and Sugiyama, Y.
- Journal Title
  
  J Pharmacol Exp Ther 328
  
  Pages: 652-662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.2009
- Author(s)
  Hirouchi M, Kusuhara H, Onuki R, Ogilvie BW, Parkinson A, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos 37(10)
  
  Pages: 2103-2111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Prediction of the effects of genetic polymorphism on the pharmacokinetics of CYP2C9 substrates from in vitro data2009
- Author(s)
  Kusama M、Maeda K、Chiba K、Aoyama A、Sugiyama Y
- Journal Title
  
  Pharm Res
  
  Volume: 26巻 Pages: 822-35
- DOI
  10.1007/s11095-008-9781-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008, KAKENHI-PROJECT-21790109
[Journal Article] The inhibition of human multidrug and toxin extrusion 1 isinvolved in the drug-drug interaction causedby cimetidine2009
- Author(s)
  Matsushima S、Maeda K、Inoue K、Ohta KY、Yuasa H、Kondo T、Nakayama H、Horita S、Kusuhara H、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 37巻 Pages: 555-559
- DOI
  10.1124/dmd.108.023911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Limited brain distribution of [3R,4R,5S]-4?acetamido-5-amino 3-(1-ethylpropoxy)-1?cyclohexene-1-carboxylate phosphate (Ro64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/S1c22a8) and multidrug resi stance-associated protein 4 (Mrp4/Abcc4).2009
- Author(s)
  Ose A, Ito M, Kusuhara H, Yamatsugu K, Kanai M, Shibasaki M, Hosokawa M, Schuetz JD, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 37
  
  Pages: 315-321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATPIBI/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.2009
- Author(s)
  Hirouchi M, Kusuhara H, Onuki R, Ogilvie BW, Parkinson A, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos 37
  
  Pages: 2103-2111
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] The eighth and ninth transmembrane domains in organic anion transporting polypeptide 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17beta-D-glucuronide.2009
- Author(s)
  Miyagawa M, Maeda K, Aoyama A, Sugiyama Y.
- Journal Title
  
  J Pharmacol Exp Ther 329(2)
  
  Pages: 551-557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Limited brain distribution of[ 3R, 4R, 5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate(Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across theblood-brain barrier mediated by organic anion transporter 3(Oat3/Slc22a8) and multidrug resistance-associated protein 4(Mrp4/Abcc4)2009
- Author(s)
  Ose A、Ito M、Kusuhara H、Yamatsugu K、Kanai M、Shibasaki M、Hosokawa M、Schuetz JD、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 37巻 Pages: 315-321
- DOI
  10.1124/dmd.108.024018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] The eighth and ninth transmembrane domains in organic anion transporting polypeptide 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17beta-D-glucuronide2009
- Author(s)
  Miyagawa M、Maeda K、Aoyama A、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 329巻 Pages: 551-557
- DOI
  10.1124/dmd.109.027193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-inding cassette transmembrane transporter subfamily C member 32008
- Author(s)
  Kobayashi K, Ito K, Takada T, Sugiyama Y, and Suzuki H
- Journal Title
  
  Pharmacogenet Genomics 18
  
  Pages: 823-833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs2008
- Author(s)
  Maeda K, Sugiyama Y
- Journal Title
  
  Drug Metab Pharmacokinet 23
  
  Pages: 223-235
- NAID
  10021956066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans2008
- Author(s)
  Kitamura S、Maeda K、Sugiyama Y
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol
  
  Volume: 377巻 Pages: 617-628
- DOI
  10.1007/s00210-008-0312-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.2008
- Author(s)
  Kobayashi K, Ito K, Takada T, Sugiyama Y, Suzuki H.
- Journal Title
  
  Pharmacogenet Genomics 18(9)
  
  Pages: 823-833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] The quantitative prediction of CYP-mediated drug interaction by physiologically based pharmacokinetic modeling2008
- Author(s)
  Kato M、Shitara Y、Sato H、Yoshisue K、Hirano M、Ikeda T、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 25巻 Pages: 1891-1901
- DOI
  10.1007/s11095-008-9607-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism2008
- Author(s)
  Suwannakul S, Ieiri I, Kimura M, Kawabata K, Kusuhara H, Hirota T, Irie S, Sugiyama Y, Higuchi S
- Journal Title
  
  J Hum Genet 53
  
  Pages: 899-904
- NAID
  10022603002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans.2008
- Author(s)
  Kitamura.S, Maeda K, Sugiyama Y
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol. 377
  
  Pages: 617-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] ファーマコゲノミクス(総論)2008
- Author(s)
  前田和哉, 杉山雄一
- Journal Title
  
  DNAチップ/マイクロアレイ臨床応用の実際(遺伝子医学MOOK10)
  
  Pages: 336-349
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] The quantitative prediction of CYP-mediated drug interaction by physiologically based pharmacokinetic modeling.2008
- Author(s)
  Kato M, Shitara Y, Sato H, Yoshisue K, Hirano M, Ikeda T, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 25
  
  Pages: 1891-1901
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney2007
- Author(s)
  Ci L, Kusuhara H, Adachi M, Schuetz JD, Sugiyama Y
- Journal Title
  
  Mol Pharmacol (in press)
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Sodium 4-phenylbutyrate induces functional cell surface expression of wild-type and PFIC2-type mutated BSEP2007
- Author(s)
  Hayashi H, Sugiyama Y
- Journal Title
  
  Hepatology (in press)
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] ATP-binding cassette subfamily G (ABCG family)2007
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  Pflugers Arch 453 (5)
  
  Pages: 735-44
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Functional involvement of multidrug resistance associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir2007
- Author(s)
  Imaoka T, Kusuhara H, Adachi M, Schuetz JD, Takeuchi K, Sugiyama Y
- Journal Title
  
  Mol Pharmacol 71 (2)
  
  Pages: 619-27
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Regional expression and activity of breast cancer resistance protein (ABCG2) in mouse intestine : overlapped distribution with sulfotransferases (SULTs)2007
- Author(s)
  Enokizono J, Kusuhara H, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos (in press)
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers.2007
- Author(s)
  Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y, Suzuki H.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 292(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Vectorial transport of enalapril by Oatplal/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers2006
- Author(s)
  Liu L, Cui Y, Chung AY, Shitara Y, Sugiyama Y, Keppler D, Pang KS
- Journal Title
  
  J Pharmacol Exp Ther 318 (1)
  
  Pages: 395-402
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep.2006
- Author(s)
  Mita S, Suzuki H, Akita H, Hayashi H, Onuki R, Hofmann AF, Sugiyama Y
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 290(3)
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Efflux mechanism of taurocholate across the rat intestinal basolateral membrane2006
- Author(s)
  Sakamoto S, Suzuki H, Kusuhara H, Sugiyama Y
- Journal Title
  
  Mol Pharm 3 (3)
  
  Pages: 275-81
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Efflux transport systems at the blood-brain barrier and blood-CSF barrier.2005
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  the proceedings : Esteva Foundation Symposium X1 (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390035
[Journal Article] Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene.2005
- Author(s)
  Hirouchi M, Suzuki H, Sugiyama Y
- Journal Title
  
  Pharm Res 22(4)
  
  Pages: 661-666
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer.2005
- Author(s)
  Yamada T., Arai T., Nagino M., Oda K., Shoda J., Suzuki H., Sugiyama Y., Nimura Y.
- Journal Title
  
  Langenbecks Arch.Surg. 390
  
  Pages: 421-429
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Active Efflux across the Blood-Brain Barrier : Role of the Solute Carrier Family.2005
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  NeuroRx 2
  
  Pages: 73-85
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390035
[Journal Article] Efflux transport systems at the blood-brain barrier and blood-CSF barrier.2005
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  Esteva Foundation Symposium X1 (in press)
- Data Source
  KAKENHI-PROJECT-15390035
[Journal Article] Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein.2005
- Author(s)
  Matsushima S., Maeda K., Kondo C., Hirano M., Sasaki M., Suzuki H., Sugiyama Y.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 314
  
  Pages: 1059-1067
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Efflux transport systems at the blood-brain barrier and blood-CSF barrier.2005
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  Int Congr Ser 1277
  
  Pages: 111-122
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390035
[Journal Article] Characterization of polarized expression of point- or deletion-mutated human BCRP/ABCG2 in LLC-PK1 cells.2005
- Author(s)
  Takada T., Suzuki H., Sugiyama Y.
- Journal Title
  
  Pharm.Res. 22
  
  Pages: 458-464
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer.2005
- Author(s)
  Yamada T, Arai T, Nagino M, Oda K, Shoda J, Suzuki H, Sugiyama Y, Nimura Y.
- Journal Title
  
  Langenbecks Arch Surg 390(5)
  
  Pages: 421-429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Lack of improvement of oral absorption of ME3277 by prodrug formation is ascribed to the intestinal efflux mediated by breast cancer resistant protein (BCRP/ABCG2).2005
- Author(s)
  Kondo C., Onuki R., Kusuhara H., Suzuki H., Suzuki M., Okudaira N., Kojima M., Ishiwata K., Jonker JW., Sugiyama Y.
- Journal Title
  
  Pharm.Res. 22
  
  Pages: 613-618
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta.2005
- Author(s)
  Kobayashi D., Ieiri I., Hirota T., Takane H., Maegawa S., Kigawa J., Suzuki H., Nanba E., Oshimura M., Terakawa N., Otsubo K., Mine K., Sugiyama Y.
- Journal Title
  
  Drug Metab.Dispos. 33
  
  Pages: 94-101
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cells.2005
- Author(s)
  Takada T, Suzuki H, Gotoh Y, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 33(7)
  
  Pages: 905-909
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Apical/Basolateral surface expression of drug transporters and its role in vectorial drug transport.2005
- Author(s)
  Ito K, Suzuki H, Horie T, Sugiyama Y.
- Journal Title
  
  Pharm Res 22
  
  Pages: 1559-1577
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11.2005
- Author(s)
  Hayashi H, Takada T, Suzuki H, Akita H, Sugiyama Y
- Journal Title
  
  Hepatology 41(4)
  
  Pages: 916-924
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen.2005
- Author(s)
  Adachi Y., Suzuki H., Schinkel AH., Sugiyama Y.
- Journal Title
  
  Mol.Pharmacol. 67
  
  Pages: 923-928
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate : A comparison of human BSEP with rat Bsep.2005
- Author(s)
  Hayashi H., Takada T., Suzuki H., Onuki R., Hofmann AF., Sugiyama Y.
- Journal Title
  
  Biochim.Biophys.Acta 1738
  
  Pages: 54-62
- Data Source
  KAKENHI-PROJECT-17081006
[Journal Article] The quantitative prediction of in vivo enzyme-induction caused by drug exposure from in vitro information on human hepatocytes2005
- Author(s)
  Kato, M., Chiba, K., Horikawa, M., Sugiyama, Y.
- Journal Title
  
  Drug Metab Pharmacokinet 20(4)
  
  Pages: 236-243
- NAID
  130004933327
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Quantitative integration of functional data for human ABC transporters: PET imaging, in vitro functional assays and proteomics.2021
- Author(s)
  Yuichi Sugiyama
- Organizer
  ABC2020 - 8th FEBS Special Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Presentation] Use of Extended Clearance Concept and PBPK Modeling in New Drug Discovery and Development: Predicting Target Tissue Exposure from In Vitro to In Vivo.2021
- Author(s)
  Yuichi Sugiyama
- Organizer
  International Transporter Consortium (ITC) 4th Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Presentation] Role of transporter sciences in new drug discovery and development.2021
- Author(s)
  Yuichi Sugiyama
- Organizer
  The 94th Annual Meeting of the Japanese Pharmacological Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Presentation] Quantitative integration of functional data for human ABC transporters: PET imaging, in vitro functional assays and proteomics.2020
- Author(s)
  Yuichi Sugiyama
- Organizer
  ABC2020 - 8th FEBS Special Meeting on ABC Proteins From Multidrug Resistance to Genetic Diseases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Presentation] プロベネシドと OAT3 基質の薬物間相互作用の個人間変動を加味したモデル構築2020
- Author(s)
  南あかり, 梅村悠人, 大阿久雅風, 阿部佐智子, 前田和哉, 吉門崇, 岡美佳子，千葉康司, 杉山雄一
- Organizer
  日本薬学会第 140 年会
- Data Source
  KAKENHI-PROJECT-17K08470
[Presentation] PBPK analysis for the prediction of in vivo drug disposition involving enteric and hepatic drug metabolism, uptake and efflux.2019
- Author(s)
  Yuichi Sugiyama
- Organizer
  The 12th International ISSX Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Presentation] Quantitative Prediction of the Hepatic Clearance and Complex Drug Interactions Using Extended Clearance Concept and Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Data.2019
- Author(s)
  Yuichi Sugiyama
- Organizer
  4th Annual Conference of the Society for the Study of Xenobiotics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Presentation] 有機アニオン輸送ポリペプチドの遺伝子多型ごとの個体間変動の推定　―腸肝循環を考慮した数学モデルによる臨床試験結果からの輸送活性変動の抽出―2019
- Author(s)
  南あかり, 千葉康司, Soo-Jin Kim, 高橋大貴, 吉門崇, 杉山雄一
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08470
[Presentation] Prediction of the effects of transporter mediated drug-drug interaction and pharmacogenomics on pharmacokinetics (PK) /pharmacodynamics (PD) / toxicodynamics (TD).2019
- Author(s)
  Yuichi Sugiyama
- Organizer
  Beijing International Symposium on Drug Metabolism and Pharmacokinetics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Presentation] 腎有機アニオントランスポータにおけるプロベネシドによる薬物間相互作用を予測するための生理学的薬物速度論に基づく母集団解析モデルの構築2019
- Author(s)
  山田莉嵯, 梅村悠人, 水畑淳之介, 前田和哉, 年本広太, 吉門崇, 千葉康司, 杉山雄一
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08470
[Presentation] Role of Transporters in pharmacokinetics (PK)/ pharmacodynamics (PD)/ toxicodynamics (TD).2019
- Author(s)
  Yuichi Sugiyama
- Organizer
  The 4th Lingnan International DMPK Forum
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Presentation] Proposal for predicting drug-drug interaction using PBPK model of coproporphyrin I as an endogeneous OATP1B biomarker.2018
- Author(s)
  Yoshikado T，Toshimoto K, Maeda K, Kusuhara K, Chiba K, Sugiyama Y.
- Organizer
  International meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08470
[Presentation] Construction of a physiologically-based pharmacokinetic model of coproporphyrin I, a putative endogenous probe for hepatic OATP1Bs and MRP2.2018
- Author(s)
  Yoshikado T, Toshimoto K, Maeda K, Kusuhara H, Chiba K, Sugiyama Y.
- Organizer
  WCP2018-18th World Congress of Basic and Clinical Pharmacology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08470
[Presentation] PBPK モデルに基づく仮想臨床試験によるタモキシフェン及び活性代謝物の血中曝露及び有効性の前向き予測.2017
- Author(s)
  中村利通, 年本広太, 今村知世, 谷川原祐介, 杉山雄一.
- Organizer
  日本薬剤学会第32年会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2017-05-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] DDIバイオマーカーとしての抱合型・非抱合型ビリルビンPBPKモデルの構築.2017
- Author(s)
  宮内正二, Kim Sae Hee, 年本広太, 楠原洋之, 杉山雄一.
- Organizer
  日本薬剤学会第32年会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2017-05-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 経口投与時におけるBosentanの非線形動態の解析.2017
- Author(s)
  田中裕太, 年本広太, 北村嘉章, 都丸充子, 杉山雄一.
- Organizer
  日本薬剤学会第32年会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2017-05-11
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Small-dosing clinical study: pharmacoki- netic, pharmacogeno-mic (SLCO2B1 and ABCG2), and interaction (atorvastatin and grapefruit Juice) profiles of five probes for OATP2B1 and BCRP.2017
- Author(s)
  Kashihara Y, Ieiri I, Yoshikado T, Maeda K, Fukae M, Kimura M, Hirota T, Matsuki S, Irie S, Izumi N, Kusuhara H, Sugiyama Y.
- Organizer
  15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
- Place of Presentation
  国立京都国際会館 (京都府京都市)
- Year and Date
  2017-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 接着型ヒト凍結肝細胞の短時間培養法によるOATP基質の取り込み評価：スループットの高い評価法を目指して.2017
- Author(s)
  森田清愛, 年本広太, 杉山雄一.
- Organizer
  日本薬剤学会第32年会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2017-05-11
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] The prediction of the relative importance of CYP3A/P-glycoprotein to the nonlinear intestinal absorption of drugs by advanced compartmental absorption and transit model.2017
- Author(s)
  Maeda K, Takano J, Bolger MB, Sugiyama Y.
- Organizer
  ASCPT 2017 Annual Meeting
- Place of Presentation
  Washington Marriott Wardman Park, Washington DC, US
- Year and Date
  2017-03-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] PBPKモデルを用いたパラメータ最適化で得られた薬物阻害定数の妥当性検討.2017
- Author(s)
  年本広太, 友田有加菜, 千葉康司, 杉山雄一.
- Organizer
  日本薬剤学会第32年会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2017-05-11
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 生理学的薬物速度論モデル及びモンテカルロシミュレーションを用いたピタバスタチンの血中濃度推移の個人間変動予測.2017
- Author(s)
  宮川麻友子, 年本広太, 千葉康司, 杉山雄一.
- Organizer
  日本薬剤学会第32年会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2017-05-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Apply a PET Approach to Monitor Hepatic Uptake and Excretory Function.2017
- Author(s)
  Sugiyama Y.
- Organizer
  Experimental Biology 2017
- Place of Presentation
  Chicago, US
- Year and Date
  2017-04-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝OATPおよびCYP3Aが関与する薬物間相互作用のPBPKモデル解析.2017
- Author(s)
  吉門崇, 前田和哉, 楠原洋之, 降旗謙一, 杉山雄一.
- Organizer
  日本薬剤学会第32年会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2017-05-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Is Prediction of Tissue Exposure from In Vitro Data Using PBPK Modeling Possible? Confirmation by PET Imaging to Study the Clinical Disposition of Membrane Transporter Substrates.2017
- Author(s)
  Sugiyama Y.
- Organizer
  ITCW 3 Pre-conference 2017
- Place of Presentation
  Washington, US
- Year and Date
  2017-03-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Perspective on transporter research; use of physiologically based pharmacokinetic modeling to predict roles of drug transporters in target tissue drug exposures.2016
- Author(s)
  Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] The Use of“Extended Clearance Concept”and PBPK Modeling to Interpret Clinical Outcomes from In Vitro Metabolism and Transport Data; focusing on the transporters in the liver.2016
- Author(s)
  Sugiyama Y.
- Organizer
  7th Clinically Relevant Drug Transporters
- Place of Presentation
  Berlin, Germany
- Year and Date
  2016-06-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Drug Transporters: Starring roles in New Drug Discovery and Development.2016
- Author(s)
  Sugiyama Y.
- Organizer
  The 11th International ISSX Meeting
- Place of Presentation
  Busan, Korea
- Year and Date
  2016-06-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Drug Transporters: Role in pharmacokinetics (PK) /pharmacodynamics (PD) /toxicodynamics (TD).2016
- Author(s)
  Sugiyama Y.
- Organizer
  2016 Fall Annual Convention of Pharmaceutical Society of Korea
- Place of Presentation
  Seoul Korea
- Year and Date
  2016-10-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 創薬, 創剤におけるトランスポーター研究の役割.2016
- Author(s)
  杉山雄一.
- Organizer
  第53回薬剤学懇談会研究討論会
- Place of Presentation
  ルネッサンスリゾートナルト（徳島県鳴門市）
- Year and Date
  2016-06-09
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 創薬、臨床開発におけるリバーストランスレーショナルリサーチ（rTR）の重要性.2016
- Author(s)
  杉山雄一.
- Organizer
  ライフサイエンスネットワーク形成事業（医薬品）平成28年度シンポジウム
- Place of Presentation
  パシフィックホテル沖縄（沖縄県那覇市）
- Year and Date
  2016-09-30
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Analysis of drug-drug interactions caused by the inhibition of hepatic organic anion transporting polypeptides using a rational physiologically based pharmacokinetic model and parameters obtained from human hepatocytes.2016
- Author(s)
  Yoshikado T, Toshimoto K, Sugiyama Y.
- Organizer
  Experimental Biology 2016
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-04-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Evaluation of the alteration in BCRP function by c.421C>A polymorphism based on PBPK analysis of rosuvastatin.2016
- Author(s)
  Futatsugi A, Toshimoto K, Yoshikado T, Kato Y, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] トランスポーターと薬物代謝酵素が関与する肝消失律速過程の解析.2016
- Author(s)
  吉門崇, 降旗聖子, 寺島花野, 中山丈史, 石亀啓子, 常本和伸, 前田和哉, 楠原洋之, 降旗謙一, 杉山雄一.
- Organizer
  日本動物実験代替法学会第29回大会
- Place of Presentation
  九州大学百年講堂（福岡県博多区）
- Year and Date
  2016-11-17
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] クロピドグレルの関与する薬物間相互作用のカセットドーズ臨床試験に基づいたメカニズム解析とin vitro試験に基づいた予測.2016
- Author(s)
  Soo-Jin Kim, 吉門崇, 家入一郎, 前田和哉, 木村美由紀, 入江伸, 楠原洋之, 杉山雄一.
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] IVIVE最近の話題.2016
- Author(s)
  杉山雄一.
- Organizer
  CBI学会第367研究講演会
- Place of Presentation
  東京大学山上会館（東京都文京区）
- Year and Date
  2016-12-15
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Analysis of nonlinear pharmacokinetics of highly albumin-bound compound.2016
- Author(s)
  Fukuchi Y, Mori T, Asaumi R, Nunoya K, Imawaka H, Toshimoto K, Miyauchi S, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Estimation of hepatic uptake transporter OATP1B1 variability: Influence of passive diffusion and metabolic intrinsic clearance on repaglinide AUC variability.2016
- Author(s)
  Chiba K, Takahashi H, Kim S.J, Takatsu T, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Predictability of human serotonin transporter occupancy by SSRI and SNRI using in vitro CNS transporter Ki values and unbound plasma concentration based on literature information.2016
- Author(s)
  Yahata M, Chiba K, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 臨床で認められた非線形薬物動態の原因検討(OATP1B3による肝取込み飽和の可能性).2016
- Author(s)
  福地由希菜, 淺海竜太, 澤田健史, 戸邉慈英, 森貴則, 柿本啓輔, 河野健太, 宮内正二, 年本広太, 杉山雄一.
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] OATPs/CYP3A dual基質の薬物相互作用試験に基づいた肝消失律速過程の解析.2016
- Author(s)
  吉門崇, 降旗聖子, 寺島花野, 中山丈史, 石亀啓子, 常本和伸, 前田和哉, 楠原洋之, 降旗謙一, 杉山雄一.
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] トランスポーターの関わるヒト肝クリアランスの予測；アルブミンの関与する肝取り込みをin vitroで評価すべきか？2016
- Author(s)
  杉山雄一.
- Organizer
  第373回CBI学会講演会
- Place of Presentation
  東京大学山上会館（東京都文京区）
- Year and Date
  2016-06-02
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Identification of GCDCA-S as endogenous biomarkers for OATP1B1 and OATP1B3 in healthy subject.2016
- Author(s)
  Takehara I, Terashima H, Nakayama T, Yoshikado T, Yoshida M, Furihata K, Watanabe N, Maeda K, Ando O, Sugiyama Y, Kusuhara H.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Prediction of inter-individual differences in pharmacokinetics and drug interactions of pravastatin using physiologically based pharmacokinetics model with Monte Carlo simulation.2016
- Author(s)
  Matsumoto T, Toshimoto K, Chiba K, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Clopidogrel-mediated drug-drug interaction on CYP2C8 and OATP1B1: in vitro inhibitory effect and in vivo clinical study.2016
- Author(s)
  Kim S.J, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Quantitative prediction of hepatic uptake clearance mediated by organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 using relative activity factor-based scaling approach.2016
- Author(s)
  Izumi S, Nozaki Y, Komori T, Maeda K, Kusuhara H, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] "Albumin- mediated" hepatic transport: extrapolation to in vivo hepatic clearance from in vitro uptake data by suspended human hepatocytes in the presence of varied albumin concentrations.2016
- Author(s)
  Sugiyama Y, Kim S.J, Lee K.R, Miyauchi S.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Are inhibition constants (Ki) correctly estimated using only the blood concentration time profile of substrate drugs with and without co-administration of inhibitor drugs?2016
- Author(s)
  Toshimoto K, Tomoda Y, Chiba K, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 内在性基質の変動を利用したOATPを介した薬物間相互作用の定量的評価法の開発.2016
- Author(s)
  楠原洋之, 吉門崇, 前田和哉, 寺島花野, 中山丈史, 吉田美和, 降旗謙一, 杉山雄一.
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Analysis of complex drug-drug interactions of cerivastatin using physiol- ogically based pharmacokinetic (PBPK) modeling.2016
- Author(s)
  Yao Y, Toshimoto K, Kim S.J, Yoshikado T, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] In vitro estimation of unbound hepatocyte-to- medium concentration ratios (Kp,uu) of statins considering the membrane potential- dependent passive diffusion.2016
- Author(s)
  Yoshikado T, Toshimoto K, Nakada T, Ikejiri K, Ogawa K, Hisanaga N, Kusuhara H, Maeda K, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] PBPK model of rifampicin incorporating its hepatic uptake and auto-induction processes to predict various types of DDIs such as CYP3A/2C9 inductions and OATPs inhibitions.2016
- Author(s)
  Asaumi R, Toshimoto K, Kudo T, Sawada T, Tobe Y, Kono K, Ito K, Nunoya K, Imawaka H, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] The novel physiologically based pharmacoki- netics (PBPK) model to investigate transporter-mediated disposition and clearance of metformin in humans.2016
- Author(s)
  Nishiyama K, Toshimoto K, Ishiguro N, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 10 年後の創薬～薬剤学への期待.2015
- Author(s)
  杉山雄一
- Organizer
  日本薬剤学会創立30 周年記念シンポジウム
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝取り込みトランスポーターOATPs および代謝酵素CYP3A4 のdual 基質薬の関与する薬物間相互作用の臨床解析.2015
- Author(s)
  杉山雄一, 吉門崇, 降旗聖子, 寺島花野, 中山丈史, 石亀啓子, 常本和伸, 前田和哉, 楠原洋之, 降旗謙一.
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Clarification of the mechanism of clopidogrel-mediated drug-drug interaction on the pharmacokinetics of repaglinide in a clinical cassette small-dose study.2015
- Author(s)
  Kim S.J, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝臓におけるトランスポーターを介した薬物間相互作用の生理学的薬物速度論モデルに基づいた解析法の構築.2015
- Author(s)
  吉門崇, 杉山雄一.
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] A clinical drug interaction study using hepatic OATPs/CYP3A dual substrates: analysis of the rate-determining process based on the extended clearance concept.2015
- Author(s)
  Yoshikado T, Furihata S, Terashima H, Nakayama T, Ishigame K, Tsunemoto K, Maeda K, Kusuhara H, Furihata K, Sugiyama Y.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] トランスポーターが関与する肝取り込みおよび排出過程のサンドイッチ培養ヒト肝細胞を用いた定量的評価-肝消失律速過程の解析-2015
- Author(s)
  吉門崇, 杉山雄一.
- Organizer
  第10回トランスポーター研究会年会
- Place of Presentation
  慶應義塾大学薬学部（東京都港区）
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Significance of Uptake and Efflux Transporters in the Liver.2015
- Author(s)
  Sugiyama Y.
- Organizer
  20th North American ISSX Meeting
- Place of Presentation
  Orland, US
- Year and Date
  2015-10-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Cassette Microdosing Design to Identify Optimal Pharmacokinetic Properties.2015
- Author(s)
  Sugiyama Y.
- Organizer
  2015 Annual Meeting of American College of Clinical Pharmacology
- Place of Presentation
  San Francisco, US.
- Year and Date
  2015-09-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] CPT-11 の仮想臨床試験（Virtual Clinical Study）による臨床試験の再現.2015
- Author(s)
  年本広太, 杉山雄一.
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 医薬品開発における数理モデルの活用.2015
- Author(s)
  杉山雄一
- Organizer
  第34 回生命科学シンポジウム
- Place of Presentation
  東邦大学（千葉県船橋市）
- Year and Date
  2015-10-07
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] The Use of “Extended Clearance Concept” and PBPK Modeling to Interpret Clinical Outcomes from In Vitro Metabolism and Transport Data.2015
- Author(s)
  Sugiyama Y.
- Organizer
  IVAL Hepatocyte Technology Conference and Workshops 2015
- Place of Presentation
  Boston, US
- Year and Date
  2015-04-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] PBPK モデルを用いたrepaglinide の複雑な薬物間相互作用の解析.2015
- Author(s)
  Soo-Jin Kim, 八尾祉顕, 年本広太, 吉門崇, 杉山雄一.
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Transporters-role in pharma- cokinetics/pharmacodynamics/toxicodynamics of drugs.2015
- Author(s)
  Sugiyama Y.
- Organizer
  BioMedical Transporters 2015
- Place of Presentation
  Lugano, Switzerland
- Year and Date
  2015-08-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Construction of physiologically-based pharmacokinetic (PBPK) model of rifampicin to predict metabolic enzyme induction- and hepatic uptake transporter inhibition-mediated drug-drug interaction (DDI).2015
- Author(s)
  Asaumi R, Nunoya K, Imawaka H, Sugiyama Y.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Transporters-role in pharma- cokinetics/pharmacodynamics/toxicodynamics of drugs.2015
- Author(s)
  Sugiyama Y.
- Organizer
  45th Annual Meeting of The Korean Society of Pharmaceutical Sciences and Technology
- Place of Presentation
  Seoul, Korea
- Year and Date
  2015-11-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Predicting complex drug-drug interactions of repaglinide using physiologically based pharmacokinetic (PBPK) models with in vitro Ki data.2015
- Author(s)
  Soo-Jin Kim, 八尾祉顕, 年本広太, 吉門崇, 杉山雄一.
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] PBPK モデルを用いたCPT-11の副作用と関連性の高い因子の探索.2015
- Author(s)
  年本広太, 杉山雄一.
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 胆汁形成を担うトランスポーターのin vitro機能評価系に基づいた薬物誘発性胆汁うっ滞型肝障害のリスク評価.2015
- Author(s)
  吉門崇, 杉山雄一.
- Organizer
  日本動物実験代替法学会第28回大会,
- Place of Presentation
  ワークピア横浜（神奈川県横浜市）
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] A novel model considering a change in medium unbound fraction caused by a significant ligand-transporter binding can feasibly explain the "albumin-mediated hepatic uptake" phenomenon.2015
- Author(s)
  Miyauchi S, Masuda M, Tanaka Y, Iwakado S, Shimono K, Kim S.J, Sugiyama Y.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] サンドイッチ培養ヒト肝細胞を用いたスタチンの肝消失律速過程の予測.2015
- Author(s)
  吉門崇, Rafal P. Witek, 杉山雄一.
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Can we predict nonlinear pharmacokinetics of orally administered compounds at early stage of drug development?2015
- Author(s)
  Tomaru A, Ishigame K, Toshimoto K, Sugiyama Y.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 薬物相互作用（DDI）ガイドラインの科学的基盤.2015
- Author(s)
  杉山雄一
- Organizer
  第36回日本臨床薬理学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-12-09
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Comparative Evaluation of Unbound Intracellular-Medium (Plasma) Concentration Ratios (Kp,uu) of Poorly-Metabolized Anionic Drugs Using Rat and Human Hepatocytes.2015
- Author(s)
  Nakada T, Ikejiri K, Toshimoto K, Ogawa K, Hisanaga N, Kusuhara H, Maeda K, Sugiyama Y.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 薬物動態研究を基盤とした医薬品開発の未来像.2015
- Author(s)
  杉山雄一
- Organizer
  創剤研究コンソーシアム製剤技術研究コンソーシアム合同シンポジウム
- Place of Presentation
  立命館大学（滋賀県草津市）
- Year and Date
  2015-06-20
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Imaging Hepatic Concentrati- on and Biliary Excretion of Drugs.2015
- Author(s)
  Sugiyama Y.
- Organizer
  18th International Conference on Drug-Drug Interactions
- Place of Presentation
  Seattle, US.
- Year and Date
  2015-06-30
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Establishment of a Physiologically-based Pharmacokinetic Modeling of CPT-11 and Its Metabolites Using the Cluster Newton Method: Its Application to a Virtual Clinical Study.2015
- Author(s)
  Toshimoto K, Sugiyama Y.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] マイクロドース臨床試験と薬物動態予測.2015
- Author(s)
  杉山雄一
- Organizer
  第29 回日本医学会総会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-04-11
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] シクロスポリンの関わる時間依存的なOATP 阻害を説明する数理モデル.2015
- Author(s)
  設楽悦久, 芝崎茂樹, 杉山雄一.
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 薬物動態・薬効・副作用の個人間変動を定量的に理解する2014
- Author(s)
  杉山雄一
- Organizer
  第357回CBI学会研究講演会
- Place of Presentation
  東京都文京区、東京大学山上会館2階　大会議室
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝臓内非結合型薬物濃度を見積もるための簡便なin vitro実験法の提案2013
- Author(s)
  杉山雄一，池尻和明，前田和哉，楠原洋之
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] PARAMETER OPTIMIZATION IN PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODEL FOR THE PREDICTION OF TRANSPORTER-MEDIATED DRUG-DRUG INTERACTIONS WITH A NEW GLOBAL PARAMETER OPTIMIZATION METHOD.2013
- Author(s)
  Yoshida K, Maeda K, Kusuhara H, Konagaya A, Sugiyama Y.
- Organizer
  ASCPT 2013 Annual Meeting
- Place of Presentation
  JW Marriott, Indianapolis, Indiana, US
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝OATPを介した薬物間相互作用のPBPKモデルを用いた解析－腸肝循環を考慮した合理的なモデルへの発展－2013
- Author(s)
  吉門崇，吉田健太，中田智久，小谷直生，前田和哉，杉山雄一
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Do PBPK models predict complex DDIs where the alterations of transport and metabolism/excretion take place simultaneously?2013
- Author(s)
  Yuichi Sugiyama
- Organizer
  ASCPT 2013 Annual Meeting
- Place of Presentation
  JW Marriott, Indianapolis, Indiana, US
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] トランスポーターを介した薬物間相互作用予測のための腸肝循環およびIn vitro膜透過性を考慮した生理学的薬物速度論モデルの提案2013
- Author(s)
  吉門崇，吉田健太，前田和哉，杉山雄一
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Quantitative assessment of transporter effects on pharmacokinetics and pharmaco /toxicodynamics of drugs.2013
- Author(s)
  Yuichi Sugiyama
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Westin Harbour Castle Hotel, Toronto, Canada
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 病態時および個体差を考慮したPK/PD予測の方法論2013
- Author(s)
  杉山雄一
- Organizer
  日本薬物動態学会第27回ワークショップ
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Construction of physiologically-based pharmacokinetic models explaining drug-drug interactions via the inhibition of organic anion transporting polypeptides (OATPs)2012
- Author(s)
  Yoshikado T, Maeda K, Nakada T, Kotani N, Yoshida K, Sugiyama Y.
- Organizer
  19th Microsomes and Drug Oxidations (MDO) and 12th European ISSX Meeting
- Place of Presentation
  Grand Hotel Huis ter Duin, Noordwijk aan Zee, the Netherlands
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Microdosing and PET studies in drug transporter research2012
- Author(s)
  Yuichi Sugiyama
- Organizer
  19th Microsomes and Drug Oxidations (MDO) and 12th European ISSX Meeting
- Place of Presentation
  Grand Hotel Huis ter Duin, Noordwijk aan Zee, the Netherlands
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Advance in physiology, pharmacology, & pharmaceutical sciences: advances in research of drug transporters and metabolic enzymes: implications in drug development2012
- Author(s)
  Yuichi Sugiyama
- Organizer
  Modern Therapeutics 2012
- Place of Presentation
  University of Toronto, Toronto Canada
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 薬物動態の支配要因及び創薬標的としての薬物トランスポーター2012
- Author(s)
  杉山雄一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌、北海道(招待講演)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] 薬物動態の支配要因及び創薬標的としての薬物トランスポーター2012
- Author(s)
  杉山雄一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌、北海道
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Transporter-mediated drug-drug interactions in the liver from in vitro data2012
- Author(s)
  Yuichi Sugiyama
- Organizer
  DDI-2012 15th International Conference on Drug-drug Interactions:
- Place of Presentation
  the Red Lion Hotel, Seattle, US
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Quantitative analyses of drug-drug interactions between statins and cyclosporine A using physiologically-based pharmacokinetic models2012
- Author(s)
  Takashi Yoshikado, Kazuya Maeda, Tomohisa Nakada, Yoshihisa Shitara, Kenta Yoshida, Yuichi Sugiyama
- Organizer
  27th JSSX Annual Meeting
- Place of Presentation
  Chiba, Japan
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Predictions of transporter-mediated drug-drug interaction in the liver from in vitro data2011
- Author(s)
  Yuichi Sugiyama
- Organizer
  The 14^th International Conference on Drug-Drug interactions(DDI-2011)
- Place of Presentation
  Seattle, WA, USA
- Year and Date
  2011-06-07
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Quantitative prediction of clinically relevant transporter-mediated drug-drug interactions from in vitro data2011
- Author(s)
  Kenta Yoshida、Kazuya Maeda、YuichiSugiyama
- Organizer
  International Symposium on BA/BE of Oral Drug Products
- Place of Presentation
  神戸、兵庫県
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] トランスポーターを介する生体膜輸送論:薬物間相互作用、遺伝子多型の解析2011
- Author(s)
  杉山雄一
- Organizer
  北海道大学大学院薬学系研究科特別講演会
- Place of Presentation
  札幌、北海道(招待講演)
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] 薬物トランスポーター機能解析に活かすPETイメージング:創薬への応用2011
- Author(s)
  杉山雄一
- Organizer
  岡山分子イメージング高度専門人材育成事業キックオフシンポジウム
- Place of Presentation
  岡山
- Year and Date
  2011-02-02
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Drug Transporters : Roles in new drug discovery and development2011
- Author(s)
  Yuichi Sugiyama
- Organizer
  The 8^<th> symposium on New Developments in Clinical Pharmacy and Clinical Pharmacology/8^<th> Retrometabolism Based Drug Design and Targeting Conference
- Place of Presentation
  Graz, Austria(招待講演)
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Drug Transporters : Rolesin new drug discovery and development2011
- Author(s)
  Yuichi Sugiyama
- Organizer
  The 8^th symposium on New Developments in Clinical Pharmacy and Clinical Pharmacology/8^th Retrometabolism Based Drug Design and Targeting Conference
- Place of Presentation
  Graz, Austria
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] The importance of organic anion transporting polypeptide (OATP) 2B1 to the intestinal drug absorption2011
- Author(s)
  Shinya Fukizawa, Kazuya Maeda, Mayuko Miyagawa, Ichiro Ieiri, Miyuki Kimura, Shin Irie, Kazuhide Iwasaki, Yuichi Sugiyama
- Organizer
  International Symposium on BA/BE of Oral Drug Products
- Place of Presentation
  神戸、兵庫県
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Transporters : clinical relevance and IVIVE in drug discovery2011
- Author(s)
  Yuichi Sugiyama
- Organizer
  The 20^<th> Helsinki Drug Research Congress (HDR 2011)
- Place of Presentation
  Helsinki, Finland(招待講演)
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Drug transporters : Rolesin new drug discovery and development2011
- Author(s)
  Yuichi Sugiyama
- Organizer
  Gordon Research Conference on Drug Metabolism
- Place of Presentation
  Holderness, NH, USA
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] トランスポーターを介する生体膜輸送論:薬物間相互作用、遺伝子多型の解析2011
- Author(s)
  杉山雄一
- Organizer
  北海道大学大学院薬学系研究科特別講演会
- Place of Presentation
  札幌、北海道
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Predictions of transporter-mediated drug-drug interaction in the liver from in vitro data2011
- Author(s)
  Yuichi Sugiyama
- Organizer
  The 14^<th> International Conference on Drug-Drug interactions (DDI-2011)
- Place of Presentation
  Seattle, WA, USA(招待講演)
- Year and Date
  2011-06-07
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Transporters : clinical relevance and IVIVE in drug discovery2011
- Author(s)
  Yuichi Sugiyama
- Organizer
  The 20^th Helsinki Drug Research Congress(HDR 2011)
- Place of Presentation
  Helsinki, Finland
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Transporters on the target organs and clearance organs are responsible for drug induced toxicities2011
- Author(s)
  Yuichi Sugiyama
- Organizer
  Bio Medical Transporters 2011
- Place of Presentation
  Grindelvald, Switzerland
- Year and Date
  2011-08-08
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Drug transporters : Roles in new drug discovery and development2011
- Author(s)
  Yuichi Sugiyama
- Organizer
  Gordon Research Conference on Drug Metabolism
- Place of Presentation
  Holderness, NH, USA(招待講演)
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Application of PBPK modeling and clearance concept to drug showing transporter-mediated distribution and clearance in humans2011
- Author(s)
  Yuichi Sugiyama
- Organizer
  The 4^th Asia Pacific Regional ISSX Meeting
- Place of Presentation
  Tainan, Taiwan
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] The importance of organic anion transporting polypeptide(OATP) 2B1 to the intestinal drug absorption2011
- Author(s)
  Shinya Fukizawa、Kazuya Maeda、Mayuko Miyagawa、Ichiro Ieiri、Miyuki Kimura、Shin Irie、Kazuhide Iwasaki、Yuichi Sugiyama
- Organizer
  International Symposium on BA/BE of Oral Drug Products
- Place of Presentation
  神戸、兵庫県
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Transporters on the target organs and clearance organs are responsible for drug induced toxicities2011
- Author(s)
  Yuichi Sugiyama
- Organizer
  BioMedical Transporters 2011
- Place of Presentation
  Grindelvald, Switzerland(招待講演)
- Year and Date
  2011-08-08
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Application of PBPK modeling and clearance concept to drug showing transporter-mediated distribution and clearance in humans2011
- Author(s)
  Yuichi Sugiyama
- Organizer
  The 4^<th> Asia Pacific Regional ISSX Meeting
- Place of Presentation
  Tainan, Taiwan(招待講演)
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Eighth International2010
- Author(s)
  Yuichi Sugiyama Tramsporters
- Organizer
  Workshop on Pharmacodynamics of anticancer agents
- Place of Presentation
  箱根
- Year and Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Microdosing in human trials2010
- Author(s)
  Yuichi Sugiyama
- Organizer
  The 6th Uppsala Spring Meeting
- Place of Presentation
  Uppsala, Sweden
- Year and Date
  2010-04-13
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Theoretical Prediction of transporter-mediated drug-drug interaction2010
- Author(s)
  Kazuya Maeda, Yuichi Sugiyama
- Organizer
  2010 FIP PSWC/RAPS annual meeting and exposition
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] 医薬品の探索・開発における薬物トランスポーター研究の重要性2010
- Author(s)
  杉山雄一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Rate-determining process of a co-substrate of uptake transporter and metabolizing enzyme in the liver2010
- Author(s)
  Yuichi Sugiyama
- Organizer
  MD02010
- Place of Presentation
  Beijing, China
- Year and Date
  2010-05-17
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] IVIVE for hepatic and renal transporters2010
- Author(s)
  Hiroyuki Kusuhara, Yuichi Sugiyama
- Organizer
  2010 FIP PSWC/RAPS annual meeting and exposition
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Tramsporters2010
- Author(s)
  Yuichi Sugiyama
- Organizer
  Eighth International Workshop on Pharmacodyna mics of anticancer agents
- Place of Presentation
  箱根
- Year and Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Theoretical Prediction of transporter-mediated drug-drug interaction2010
- Author(s)
  Kazuya Maeda, Yuichi Sugiyama
- Organizer
  2010 FIP PSWC/AAPS annual meeting and exposition
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Rate-determining process of a co-substrate of uptake transporter and metabolizing enzyme in the liver2010
- Author(s)
  Yuichi Sugiyama
- Organizer
  MDO2010
- Place of Presentation
  Beijing, China
- Year and Date
  2010-05-17
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] IVIVE for hepatic and renal transporters2010
- Author(s)
  Hiroyuki Kusuhara, Yuichi Sugiyama
- Organizer
  2010 FIP PSWC/AAPS annual meeting and exposition
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Drug Metabolizing Enzymes and Transporters in Drug-Drug Interactions : A Pharmacokinetic Treatment2010
- Author(s)
  Yuichi Sugiyama
- Organizer
  13th International Conference on Drug-Drug Interactions
- Place of Presentation
  Seattle, USA
- Year and Date
  2010-06-14
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Clinical significance of pharmacogenomics and drug-drug interaction in transporter-mediated pharmacokinetics/pharmacodynamics2010
- Author(s)
  Yuichi Sugiyama
- Organizer
  TWELFTH BUFFALO PHARMACEUTICS SYMPOSIUM
- Place of Presentation
  Buffalo, USA
- Year and Date
  2010-07-30
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] ROLE OF MURINE Oatp1a4 IN THE HEPATIC UPTAKE OF DRUGS IN MICE2009
- Author(s)
  Junichi Takano, Kazuya Maeda and Yuichi Sugiyama
- Organizer
  Asian Federation for Pharmaceutical Sciences 2009
- Place of Presentation
  福岡
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] トランスポーターを介した薬物間相互作用による血漿中・組織中濃度の変動のin vitro実験に基づく定量的予測法の検討2009
- Author(s)
  前田和哉、北村吏司、杉山雄一
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] QUANTITATIVE PREDICTION OF THE CLEARANCE PATHWAYS OF TRANSPORTER SUBSTRATES FROM IN VITRO EXPERIMENTS2009
- Author(s)
  Kazuya Maeda, Yuichi Sugiyama
- Organizer
  7^<th> Retrometabolism Based Drug Design and Targeting
- Place of Presentation
  Florida, USA
- Year and Date
  2009-05-12
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Clinical significance of pharmacogenomics and drug-drug interaction in OATPs-mediated pharmacokinetics/pharmacodynamics2009
- Author(s)
  杉山雄一
- Organizer
  BioMedical Transporters 2009
- Place of Presentation
  Thun, Switzerland
- Year and Date
  2009-08-10
- Data Source
  KAKENHI-PROJECT-20018006
[Presentation] QUANTITATIVE PREDICTION OF THE CLEARANCE PATHWAYS OF TRANSPORTER SUBSTRATES FROM IN VITRO EXPERIMENTS2009
- Author(s)
  Kazuya Maeda, Yuichi Sugiyama
- Organizer
  7th Retrometabolism Based Drug Design and Targeting
- Place of Presentation
  Florida, USA
- Year and Date
  2009-05-12
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] ヒト薬物トランスポーターの遺伝子多型がグリチルリチンの薬物動態に与える影響2009
- Author(s)
  前田和哉, 滝川一, 出堀泰之, 江頭徹, 杉山雄一
- Organizer
  日本人類遺伝学会第54回大会
- Place of Presentation
  東京
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-20018006
[Presentation] QUANTITATIVE PREDICTION OF THE CLEARANCE PATHWAYS OF TRANSPORTER SUBSTRATES FROM IN VITRO EXPERIMENTS2009
- Author(s)
  Kazuya Maeda and Yuichi Sugiyama
- Organizer
  7^th Retrometabolism Based Drug Design and Targeting
- Place of Presentation
  Florida, USA
- Year and Date
  2009-05-12
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] CAN DRUG CONCENTRATION IN THE CEREBROSPINAL FLUID BE A SURROGATE FOR THE UNBOUND CONCENTRATION OF CNS DRUGS IN THE BRAIN? : In vitro to in vivo prediction2009
- Author(s)
  Yuichi Sugiyama
- Organizer
  North American ISSX
- Place of Presentation
  Baltimore, USA
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Drug Transporters in the New Drug Discovery and Development2009
- Author(s)
  Yuichi Sugiyama
- Organizer
  3rd Asian Pacific Regional Meeting of ISSX
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2009-05-10
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] CAN DRUG CONCENTRATION IN THE CEREBROSPINAL FLUID BE A SURROGATE FOR THE UNBOUND CONCENTRATION OF CNS DRUGS IN THE BRAIN?: In vitro to in vivo prediction2009
- Author(s)
  Yuichi Sugiyama
- Organizer
  North American ISSX
- Place of Presentation
  Baltimore, USA
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Clinical significance of pharmacogenomics and drug-drug interaction in OATPs-mediated pharmacokinetics/pharmacodynamics2009
- Author(s)
  Yuichi Sugiyama
- Organizer
  BioMedical Transporters 2009
- Place of Presentation
  Thun, Switzerland
- Year and Date
  2009-08-09
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Clinical significance of pharmacogenomics and drug-drug interaction in OATPs-mediated pharmacokinetics/pharmacodynamics2009
- Author(s)
  Yuichi Sugiyama
- Organizer
  BioMedical Transporters2009
- Place of Presentation
  Thun, Switzerland
- Year and Date
  2009-08-09
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] ROLE OF MURINE Oatpla4 IN THE HEPATIC UPTAKE OF DRUGS IN MICE2009
- Author(s)
  Junichi Takano, Kazuya Maeda, Yuichi Sugiyama
- Organizer
  Asian Federation for Pharmaceutical Sciences 2009
- Place of Presentation
  福岡
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] 薬物トランスポーターが関与する薬物間相互作用の事例解析と予測法の構築へ向けて2008
- Author(s)
  前田和哉、杉山雄一
- Organizer
  第12回薬物動態談話会セミナー
- Place of Presentation
  つくば
- Year and Date
  2008-08-21
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] トランスポーターレベルの薬物間相互作用:in vitro実験データと臨床データの対応付け2008
- Author(s)
  前田和哉、杉山雄一
- Organizer
  CBI研究講演会
- Place of Presentation
  東京
- Year and Date
  2008-07-14
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] トランスポーターレベルめ薬物間相互作用:in vitro実験データと臨床デー汐の対応付け2008
- Author(s)
  前田和哉、杉山雄一
- Organizer
  CBI研究講演会
- Place of Presentation
  東京
- Year and Date
  2008-07-14
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Integration of In Vitro and In Vivo Data of Transporter Mediated Drug-drug Interaction and Pharmacogenomics2008
- Author(s)
  Yuichi Sugiyama
- Organizer
  2nd Asian-Pasific ISSX meeting
- Place of Presentation
  Shanghai, China
- Year and Date
  2008-05-12
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] SEARCH AND VALIDATION OF IN VIVO PROBE DRUGS FOR FUNCTIONAL ANALYSIS OF OAT1 AND OAT3 IN HUMANS2008
- Author(s)
  Tian Y, Maeda K, Kumagai Y, Kondo T, Kusuhara H and Sugiyama Y
- Organizer
  日本薬物動態学会第23回年会
- Place of Presentation
  熊本
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Non-selective inhibitors of hepatic influx and efflux transporters : Implications to pharmacokinetics and hepatic drug disposition2008
- Author(s)
  Yuichi Sugiyama
- Organizer
  FDA Critical Path Transporter Workshop
- Place of Presentation
  Bethesda, USA
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] トラとスポーターの遺伝子多型が薬物動態・薬効に与えるインパクト〜OATP1B1, BCRPを中心に〜2008
- Author(s)
  前田和哉、杉山雄一
- Organizer
  日本臨床薬理学会第29回年会
- Place of Presentation
  東京
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-20018006
[Presentation] Non-selective inhibitors of hepatic influx and efflux transp orters: Implications to pharmacokinetics and hepatic drug di sposition2008
- Author(s)
  Sugiyama Y
- Organizer
  FDA Critical Path Transporter Workshop
- Place of Presentation
  Bethesda, USA
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Integration of In Vitro and In Vivo Data of Transporter Mediated Drug?drug Interaction and Pharmacogenomics2008
- Author(s)
  Sugiyama Y
- Organizer
  2nd Asian7Pasific ISSX meeting
- Place of Presentation
  上海、中国
- Year and Date
  2008-05-12
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] P-glycoprotein and other efflux transporters (Bcrp, Mrp2) on the luminal membrane in absorption, distribution, and elimination2008
- Author(s)
  Sugiyama Y
- Organizer
  2008 AAPS Annual Meeting & Exposition
- Place of Presentation
  Atlanta, USA
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Integration of In Vitroand In Vivo Data of Transporter Mediated Drug-drug Interaction and Pharmacogenomics2008
- Author(s)
  Yuichi Sugiyama
- Organizer
  2nd Asian-Pasific ISSX meeting
- Place of Presentation
  上海、中国
- Year and Date
  2008-05-12
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] P-glycoprotein and other efflux transporters(Bcrp, Mrp2) on the luminal membrane in absorption, distribution, and elimination2008
- Author(s)
  Yuichi Sugiyama
- Organizer
  2008 AAPS Annual Meeting & Exposition
- Place of Presentation
  Atlanta, USA
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] 肝細胞血管側の胆汁酸排泄輸送体ABCC3/MRP3遺伝子多型の機能解析2007
- Author(s)
  伊藤晃成, 小林和弘, 高田龍平, 杉山雄一, 鈴木洋史
- Organizer
  第29回胆汁酸研究会
- Place of Presentation
  つくば
- Year and Date
  2007-11-24
- Data Source
  KAKENHI-PROJECT-17081006
[Presentation] Effect of phosphorylation of Akt on polarized expression of human BCRP/ABCG2.2006
- Author(s)
  Takada T, Suzuki H, Sugiyama Y.
- Organizer
  ABC2006 FEBS Special Meeting on ABC Proteins
- Place of Presentation
  Innsbruck, Austria.
- Data Source
  KAKENHI-PROJECT-17081006
[Presentation] Influx and Efflux Transporters in the Blood Brain and Blood-CSF Barriers2006
- Author(s)
  Sugiyama Y
- Organizer
  The 1st Asian-Pacific ISSX Meeting
- Place of Presentation
  Jeju, Korea
- Year and Date
  2006-05-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Drug Transporters in the new drug discovery and development2006
- Author(s)
  Sugiyama Y
- Organizer
  The 33rd Annual Meeting of the Controlled Release Society
- Place of Presentation
  Vienna, Austria
- Year and Date
  2006-07-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Drug transporters in the new drug discovery and development2006
- Author(s)
  Sugiyama Y
- Organizer
  The 33rd Annual Meeting of the Controlled Release Society
- Place of Presentation
  Vienna, Austria
- Year and Date
  2006-07-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Influx and Efflux Transporters in the Blood Brain and Blood-CSF Barriers2006
- Author(s)
  Sugiyama Y
- Organizer
  The 15t Asian- Pasific ISSX Meeting
- Place of Presentation
  Jeju, Korea
- Year and Date
  2006-05-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Computational and in vitro approaches for predicting drug metabolism and pharmacokinetics in humans2006
- Author(s)
  Sugiyama Y
- Organizer
  The 15th World Congress of Pharmacology (IUPHAR2006)
- Place of Presentation
  Beijing, China
- Year and Date
  2006-07-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Assessment of Transport of New Drug Candidates to Predict the optimum ADME properties2006
- Author(s)
  Sugiyama Y
- Organizer
  2006 AAPS Annual Meeting and Exposition
- Place of Presentation
  San Antonio, USA
- Year and Date
  2006-10-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Computational and in vitro Approaches for Predicting Drug Metabolism and Pharmacokinetics in Humans2006
- Author(s)
  Sugiyama Y
- Organizer
  The 15th World Congress of Pharmacology (IUPHAR2006)
- Place of Presentation
  Beijing, China
- Year and Date
  2006-07-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Prediction of transporter- and enzyme-mediated complicated drug-drug interaction: taking Cerivastatin, withdrawn from the market due to its induced rhabdomyolysis as an example of victim drug
- Author(s)
  Kim S.J, Yao Y, Toshimoto K, Yoshikado T, Sugiyama Y.
- Organizer
  日本動物実験代替法学会第27回大会
- Place of Presentation
  神奈川県横浜市、横浜国立大学
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Complex DDIs: The Use of "extended clearance concept" and "PBPK Modeling" to interpet the clinical DDI outcomes from in vitro metabolism and transport data.
- Author(s)
  Sugiyama Y
- Organizer
  AAPS Annual Meeting and Exposition, PSJ-AAPS symposium
- Place of Presentation
  California, US
- Year and Date
  2014-11-03 – 2014-11-06
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Quantitative assessment of a role of hepatic transporters in the hepatic clearance and drug-drug interactions.
- Author(s)
  Sugiyama Y
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  California, US
- Year and Date
  2014-10-19 – 2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 機械学習を用いた9つの主要なin vivo薬物クリアランス経路のin silico予測
- Author(s)
  年本広太、若山直美、堀田駿、前田和哉、石田貴士、秋山泰、杉山雄一
- Organizer
  日本動物実験代替法学会第27回大会
- Place of Presentation
  神奈川県横浜市、横浜国立大学
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] サンドイッチ培養ヒト肝細胞を用いたスタチン系薬剤の肝臓除去における律速過程の予測
- Author(s)
  吉門崇、Rafal P. Witek、杉山雄一
- Organizer
  日本動物実験代替法学会第27回大会
- Place of Presentation
  神奈川県横浜市、横浜国立大学
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Clinical significance of uptake and efflux transporters in the liver.
- Author(s)
  Sugiyama Y
- Organizer
  7th SFB35-Symoisum
- Place of Presentation
  Vienna, Austria
- Year and Date
  2014-09-08 – 2014-09-10
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] CLINICAL EVALUATION OF OATPs AND MRP2 ACTIVITY USING POSITRON EMISSION TOMOGRAPHY (PET) WITH [11C]DEHYDROPRAVASTATIN
- Author(s)
  Shingaki T, Tanaka M, Ishii A, Katayama Y, Tazawa S, Wada Y, Cui Y, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  California, US
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Translational Clinical Research of OATPs and MRP2 Activity Using Positron Emission Tomography (PET) with 11C-Dehydropravastatin.
- Author(s)
  Shingaki T, Tanaka M, Ishii A, Katayama Y, Tazawa S, Wada Y, Cui Y, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y
- Organizer
  World Molecular Imaging Congress 2014
- Place of Presentation
  Soul, Korea
- Year and Date
  2014-09-17 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Analysis of drug-drug interactions between cerivastatin and interacting drugs, cyclosporine A and gemfibrozil, using physiologically based pharmacokinetic (PBPK) model.
- Author(s)
  Kim S.J, Yao Y, Yoshikado T, Toshimoto K, Sugiyama Y
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  California, US
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Establishing a versatile analysis method of drug-drug interactions with the physiologically-based pharmacokinetic model using the Cluster Newton Method.
- Author(s)
  Toshimoto K, Yoshida K, Yoshikado T, Maeda K, Kusuhara H, Konagaya A, Sugiyama Y
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  California, US
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] トランスポーターを介した薬物間相互作用のモデリング事例
- Author(s)
  吉門崇、杉山雄一
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  埼玉県さいたま市、大宮ソニックシティビル
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-24229002

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104. 崔翼龍

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
105. 鈴木正昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
106. 桂敏也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
107. 米澤淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
108. 梶本哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
109. 宮内正二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
110. 佐賀恒夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
111. 犬伏正幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
112. 横山修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
113. 大山伸幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
114. 伊藤秀明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sugiyama Yuichi 杉山 雄一

SUGIYAMA Yuichi 杉山 雄一

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トランスポーターの関わる複雑な薬物間相互作用の 定量的予測法の統合的開発Principal Investigator

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薬物組織移行・薬効・副作用の支配要因の変動を考慮したバーチャル臨床試験系の確立Principal Investigator

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Development of quantitative prediction methods for alteration in pharmacokinetics caused by interindividual variability in transporter function and transporter-mediated drug-drug interactionPrincipal Investigator

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異物解毒システムの個人間変動要因に基づいた抗癌剤処方の最適化戦略の開発Principal Investigator

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薬物動態・薬効の変動に関与する薬物トランスポーターの遺伝子多型の包括的実証研究Principal Investigator

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Development of probe drugs for the evaluation of the functions of drug transporters in vivo in humansPrincipal Investigator

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Development of the quantitative prediction method of pharmacokinetics with considering the function of metabolic enzymes and transportersPrincipal Investigator

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New strategy for the drug development of CNS acting drugs by regulating drug transport across the blood-brain barrierPrincipal Investigator

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Drug design based on the substrate specificity of the efflux transporters expressed in the blood-brain barrierPrincipal Investigator

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Sugiyama Yuichi 杉山雄一

SUGIYAMA Yuichi 杉山雄一

トランスポーターの関わる複雑な薬物間相互作用の定量的予測法の統合的開発Principal Investigator