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HANANO Manabu
花野 学
Connect your ORCID iD
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Researcher Number
60012598
Affiliation (based on the past Project Information)
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1993 – 1996: 日本大学, 薬学部, 教授
1990: Fac. Pharm. Sci., Univ. of Tokyo, Professor, 薬学部・附属病院, 教授
1987 – 1990: 東京大学, 薬学部, 教授
1986: Faculty of Pharmaceutical Sciences, University of Tokyo, 薬学部, 教授
1985: 東京大学, 薬, 教授
Review Section/Research Field
Principal Investigator
Physical pharmacy
/
医薬分子機能学
/
Biological pharmacy
/
応用薬理学・医療系薬学
Except Principal Investigator
Physical pharmacy
/
Biological pharmacy
/
応用薬理学・医療系薬学
Keywords
Principal Investigator
Pharmacokinetics / 受容体介在性エンドサイト-シス / 上皮成長因子(EGF) / ダウンレギュレ-ション / 内在化 / receptor-mediated endocytosis / epidermal growth factor (EGF) / down-regulation / internalization / 血液・脳関門
…
More
/ 血液・脳脊髄液関門 / βーラクタム抗生物質 / 薬物速度論 / 血液-脳関門 / 血液-脳脊髄液関門 / β-ラクタム抗生物質 / 血液脳関門 / 脳毛細血管内皮細胞 / ドラッグデリバリ-システム / Blood-Brain Barrier / Blood-Cerebrospinal Fluid Barrier / beta-lactam antibiotic / 薬物体内動態 / 生理学的モデル / 細胞膜透過 / 薬物吸収 / 薬物ターゲッティング / ペプチド薬物 / 鎮痛薬 / Physiological model / Cell membrane permeation / Drug absorption / Drug targeting / Peptide drug / 【α_1】-酸性糖蛋白 / けい光色素 / プロプラノロール / 蛋白結合 / 薬物モニタリング / オロソムコイド / ファーマコキネティクス / <alpha_1> -acid glycoproterin / orosomucoid / pharmacokinetics / fluorescence probe / protein binding / 生理学的薬物速度論 / アニマルスケールアップ / 薬物の体内動態 / 動物種差 / 肝機能の局在性 / 薬物間相互作用 / physiologically based pharmacokinetics / animal scale-up / drug disposition / species difference / uneven distribution of hepatic metabolic enzymes / 強心配糖体 / ウアバイン / 心筋収縮力 / Na^+,K^+ATPase / 心臓灌流実験 / 脳 / グルコース代謝 / ベンゾジアゼピンレセプター / Na^+ / K^+ATPase / ベンゾジアゼピン / Na^+,Ka^+ATPase / Cardiac glycosides / Ouabain / Positive inotropic action / Na^+,K^+ ATPase / Isolated perfused heart / Brain / Glucose metabolism
…
More
Except Principal Investigator
drug delivery / transporter / receptor / tissue targeting / pharmacokinetics / blood-brain barrier / cloning / efflux pump / 薬物速度論 / effux pump / ドラッグデリバリー / トランスポーター / レセプター / 組織標的化 / 抗痙縮薬 / 筋弛緩薬 / ノルアドレナリン / 脊髄 / 2ーデオキシグルコース法 / バクロフェン / スリクロン / αアゴニスト / αアンタゴニスト / antispastic drugs / muscle relaxants / noradrenaline / spinal cord / 血液脳関門 / 血液脳脊髄関門 / 肝障害 / 腎障害 / 血液脳脊髄液関門 / 血液-脳関門 / 血液-脳脊髄液関門 / 脈絡叢 / 薬物脳移行 / 腎障害ラット / イミブラミン / デシプラミン / DL-プロプラノロール / Blood-brain barrier / cerebrospinal fluid / choroid plexus / renal failure / hepatic failure
Less
Research Projects
(
9
results)
Co-Researchers
(
22
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Clarification of organ specific transport mechanism of druge and its application to regulation of pharmacokinetics and pharmacodynamics
Principal Investigator
TSUJI Akira
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Physical pharmacy
Research Institution
Kanazawa University
Prediction and control effectiveness and safety of a drug by means of pharmacokinetics based on physiological and biochemical mechanism of its disposition in body.
Principal Investigator
Principal Investigator
HANANO Manabu
Project Period (FY)
1993 – 1994
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
医薬分子機能学
Research Institution
Nihon University
Kinetic analysis of receptor-mediated endocytosis of polypeptide hormones
Principal Investigator
Principal Investigator
SUGIYAMA Yuichi
, 花野 学
Project Period (FY)
1990 – 1991
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Physical pharmacy
Research Institution
University of Tokyo
Development of a drug delivery system using the receptors located on the cerebral microvessels : An approach based on the physiological pharmacokinetio model.
Principal Investigator
Principal Investigator
SUGIYAMA Yuichi
, 花野 学
Project Period (FY)
1990 – 1991
Research Category
Grant-in-Aid for Developmental Scientific Research (B)
Research Field
Physical pharmacy
Research Institution
University of Tokyo
Kinetic Analysis of the CNS Disposition of Drugs in the Renal and Hepatic Failure
Principal Investigator
IGA Tatsuji
Project Period (FY)
1988 – 1990
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
応用薬理学・医療系薬学
Research Institution
The University of Tokyo
Kinetical analysis of pharmacodynamics based on drug-receptor interactions
Principal Investigator
Principal Investigator
HANANO Manabu
Project Period (FY)
1987 – 1988
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Physical pharmacy
Research Institution
University of Tokyo
Pharmacological and Pharmacokinetic Studies on Anti-spastic Drugs
Principal Investigator
FUKUDA Hideomi
Project Period (FY)
1987 – 1988
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Biological pharmacy
Research Institution
The University of Tokyo
Comprehensive study on the predition of drug disposition based on the physiological and anatomical mechanism.
Principal Investigator
Principal Investigator
HANANO Manabu
Project Period (FY)
1985 – 1986
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
応用薬理学・医療系薬学
Research Institution
University of Tokyo
Development of a simple and rapid determination method of <alpha_1> -acid glycoprotein in plasma.
Principal Investigator
Principal Investigator
HANANO Manabu
Project Period (FY)
1984 – 1985
Research Category
Grant-in-Aid for Developmental Scientific Research
Research Field
Biological pharmacy
Research Institution
The University of Tokyo
# of Projects (Dsc)
# of Projects (Asc)
1.
SUGIYAMA Yuichi
(80090471)
# of Collaborated Projects:
8 results
# of Collaborated Products:
0 results
2.
SAWADA Yasufumi
(80114502)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
3.
AWAZU Souji
(60012621)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
4.
FUKUDA Hideomi
(50080172)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
5.
IGA Tatsuji
(60012663)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
6.
TUJI Akira
(10019664)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
7.
SUZUKI Hiroshi
(80206523)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
YATA Noboru
(70028835)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
9.
HAYASHI Masahiro
(20012669)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
10.
MAYUMI Tadanori
(00098485)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
11.
HASHIDA Mitsuru
(20135594)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
HORI Ryohei
(40001036)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
HOSHI Takeshi
(60004537)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
MATSUMOTO Kinzo
(10114654)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
ONO Hideki
(00080200)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
SUGIMOTO Tsuneaki
(60019883)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
山本 郁男
(50069746)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
渡辺 淳
(80080175)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
原島 秀吉
(00183567)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
SASAHARA Kunihiro
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
KOBAYASHI Yutaka
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
KURITA Masahiro
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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