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OHNISHI Yasuyuki  大西 保行

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ONISHI Yasuyuki  大西 保行

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Researcher Number 70201382
Other IDs
Affiliation (Current) 2020: 公益財団法人実験動物中央研究所, 理事長付, 研究員
Affiliation (based on the past Project Information) *help 2012: 公益財団法人実験動物中央研究所, その他部局等, 研究員
2012: 実験動物中央研究所, 研究員
2011: 慶應義塾大学, 実験動物中央研究所, 研究員
2010: (財)実験動物中央研究所, バイオメディカル研究部, 室長
2007: Central Institute for Experimental Animals, バイオメディカル研究部, 室長 … More
2007: Central Institute for Experimental Animals, Oncology Laboratory, Group director
2005 – 2006: (財)実験動物中央研究所, バイオメディカル研究部, 室長
2005 – 2006: 東海大学, 実験動物中央研究所, 研究員
2004: 実験動物中央研究所, 研究員
2003 – 2004: 実験動物中央研究所, プロジェクト推進センター, 副部長
2000 – 2003: Central Institute for Experimental Animals Lab.Oncology Head, 腫瘍研究室, 室長
2002: Cent. Inst. Exp. Anim. Lab. Oncology Head, 腫瘍研究室, 室長
2002: 実験動物中央研究所, プロジェクト推進センター, 副部長(研究職)
2001: 実験動物中央研究所, 腫瘍研究室, 室長
2001: Central Inst. of Exp. Anim., Group Director (Researcher), 実験動物中央研究所, 室長(研究職)
2001: 財団法人実験動物中央研究所, 腫瘍研究室, 研究員
2000 – 2001: 実験動物中央研究所, 室長(研究職)
1999: 財団法人 実験動物中央研究所, 腫瘍研究室, 室長
1998: 実験動物中央研究所, 腫瘍研究室, 室長
1998: Cent.Inst.expr.Anim. Laboratory of Oncology Researcher, 腫瘍研究室, 研究員
1995 – 1998: Head, Central Inst.Expr.Anim., 腫瘍研究室, 室長
1996: 財団法人実験動物中央研究所, 腫瘍研究室, 研究員
1995: 財団法人 実験動物中央研究所, 腫瘍研究室, 室長
1995: 財団法人 歛験動物中央研究所, 腫瘍研究室, 研究員
1994 – 1995: 実験動物中央研究所, 腫瘍研, 研究員
1994: 財団法人実験動物中央研究所, 腫瘍研究室, 研究員
1993: (財)実験動物中央研究所, 腫瘍研究室, 研究員
1991 – 1992: 実験動物中央研究所, 研究員 Less
Review Section/Research Field
Principal Investigator
Laboratory animal science / Laboratory animal science
Except Principal Investigator
Laboratory animal science / Biomedical engineering/Biological material science / Human pathology / Pathological medical chemistry / Laboratory animal science
Keywords
Principal Investigator
マウス / ヌードマウス / xenograft / mouse / ヒト腫瘍 / human neoplasm / トランスジェニック / DNAフィンガープリント / ヒト癌 / ヒト … More / ゼノグラフト / リボザイム / ribozyme / vascular endotherial growth factor / xenotransplantability / K-ras / H-ras / IL-6 / bigenic / トランスレーショナル研究 / scid遺伝子 / DNAリン酸化キナーゼ / カタリーティックサブユニット / トポイソメラーゼ / RAG-2 ノックアウト / DNA障害 / DNA修復 / DNA-PKcs遺伝子 / 異種移植 / 品質管理 / 薬剤感受性 / HLA / ras / 抗癌剤スクリーニング / Xenograft / フィンガープリント / mice, nude / quality control / DNA finger print / chemosensitivity / トキシコキネティクス / ファーマコキネティクス / 抗癌剤 / I型薬剤 / サル / トキシコテネティクス / I型抗癌剤 / 濃度時間積 / マイトマイシンC / サイクロフォスファミド / シスプラチン / toxicokinetics / pharmacokinetics / anticancer drug / type I agent / monkey / human / 血管内皮成長因子 / 異種移植性 / 上皮成長因子受容体 / C-erb B / 乳酸脱水素酵素ウイルス / GM-CSF / 血管内皮増殖因子 / P-glycoprotein / SCIDマウス / アイソフォーム / G-CSF / 腫瘍 / オーソトピック移植 / P.glycoprotein / c-erbB-2 / ヒト型抗体 / epidermal growth factor receptor / c-erb Bhuman neoplasm / テトラサイクリン / インスリン / 発現誘導 / VEGF / 発現調節 / スイッチ / insulin / tetracyclin / ノックアウト / がん予防 / ウレタン / トランスジェニツク / 肺がん / ビニルカーバメート / 変異 / ビニールカーバメート / p53 / メチルニトロソウレア / transgenic / knockout / cancer prevention / urethane / マイクロアレイ / 抗がん剤 / 耐性 / オーダーメード医療 / human tumor / nude mouse / microarray / ant-cancer drug / eresistance / htranslational research / personalized chemotherapy / 2型糖尿病 / IRS-2 / 系統育成 / インシュリン抵抗性 / 系統 / PPAR / 糖尿病 / 実験動物 / ノックアウトマウス / 遺伝的背景 / 体外受精 / 自然交配 / type 2 diabetes / TRS-2 / strain / translational research / insulin resistance … More
Except Principal Investigator
DNAトポイソメラーゼ / CPT-11 / VP-16 / NOGマウス / 担癌動物 / RT-PCR / c-Ha-ras / p53 / HIV-1 / HTLV-1 / heme oxygenase / nitric oxide / soluble guanylate cyclase / ADR / 化学療法 / 耐性 / SN-38 / マイクロRNA / アパタイトナノキャリア / がん遺伝子 / 胃がん / 担がん動物 / 細胞内導入 / 胃癌 / シスプラチン / 5-FU / 癌幹細胞 / 食道腺癌 / 癌遺伝子 / 多剤耐性遺伝子 / in vivo抗癌剤感受性 / 腫瘍Xenogaft / P糖蛋白質 / 病理診断 / P糖蛋白 / ヌ-ドマウス / PCR / Multidrug Resistance / P-giycoprotein / In vivo Chemotherapy / Tumor Xenograft / MDR1 gene / ヒト腫瘍 / 免疫不全動物 / ヌードマウス / SCIDマウス / RAG-2ノックアウトマウス / 移植腫瘍 / 抗癌剤 / 薬剤感受性 / 薬効評価システム / Human Tumor / Immunodeficient Mouse / Nude Mouse / SCID Mouse / RAG-2ko Mouse / Cancer Xenograft / Anticancer Drug / Chemosensitivity / 発癌 / rasマウス / トランスジェニックマウス / Cancer / ras mice / transgenic mice / 実験動物 / NOD-scid, γKOマウス / 免疫不全 / 異種移植 / CD34+細胞 / NOD-scid,γKOマウス / experimental animals / NOD-scid. γc null mice / Immunodeficiency / Xenotransplantation / CD34+ stem cells / ヘムオキシゲナーゼ / 一酸化炭素 / 可溶性グアニル酸シクラーゼ / 一酸化窒素 / 遺伝子改変動物 / シスタチオニンベータシンターゼ / シスタチオニン合成酵素 / 硫化水素 / アミノ酸置換体 / ノックアウト動物 / cystathionine β synthase / 胆汁分泌 / microcirculation / heme oxgenase / carbon monoxide / hypoxia / conditional knock out mice / cystathionine beta synthase / carbon monoixde / knockout mice / cystathionine β-synthase / 微小環境 / 血管新生 / 遠隔転移 / NK細胞 / 悪性黒色腫 / 遠隔転移抑制 / トロンボスポンジン / 間質蛋白分解酵素 / マウスモデル / ヒト癌 / ADCC / in vivo / 多発性骨髄腫 / NOG mouse / Microenvironment / Angiogenesis / Metastasis / NK cell Less
  • Research Projects

    (17 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (41 People)
  •  The microRNAsfor the diagnosis and treatment of uppergastro-intestinal malignancy - application of appatite-nanocarrier -

    • Principal Investigator
      SUZUKI Hidekazu
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Keio University
  •  Animal Experimentation system as an infrastructure to support translational progression of diabetes research to medical practicePrincipal Investigator

    • Principal Investigator
      YOSUYUKI Ohnishi
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Development of in vivo experimental system for analyses of human cancer inductive microenvironment by using NOG mice

    • Principal Investigator
      UEYAMA Yoshito
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Tokai University
  •  Analysis of molecular mechanisms by which heme oxygenase-carbon monoxide pathway regulates cellular functions under physiological and pathophysiological conditions using newly developed gene targeting mice.

    • Principal Investigator
      SUEMATSU Makoto
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Keio University
  •  Establishment of human tumor xenotransplantation models as a pre-clinical assisting tool for translational researchPrincipal Investigator

    • Principal Investigator
      OHNISHI Yasuyuki
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  The studies on the practical application of NOD-sc/d, yc null mice allowing an efficient transplantation of human cells, to human disease models

    • Principal Investigator
      ITO Mamoru
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Study of control mechanisms of gene expression related to colorectal cancer by intestinal flora in rasH2 mice

    • Principal Investigator
      ITOH Kikuji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      The University of Tokyo
  •  Studies on in vivo evaluation system of treatment for cancer prevention and progression using cancer prone gene-engineered micePrincipal Investigator

    • Principal Investigator
      OHNISHI Yasuyuki
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Knock-down mouse, a novel gene engineering mouse for use as a disease modelPrincipal Investigator

    • Principal Investigator
      OHNISHI Yasuyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  核酸毒作用動態に基づくDNA-PKcs/scid遺伝子のDNA修復再構成機構解析Principal Investigator

    • Principal Investigator
      大西 保行
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Improvement of human tumor xenograft-mouse model as a preclinical evaluation system of new drugs discovered and developed by the novel strategy against cancerPrincipal Investigator

    • Principal Investigator
      OHNISHI Yasuyuki
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  自然耐性ヒト癌の耐性機構の解明とCPT-11耐性遺伝子を応用した遺伝子治療の試み

    • Principal Investigator
      安藤 俊夫
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Soka University
  •  A new approach for prediction of clinical efficacy of anticancer drugs based on toxicokinetic and pharmacokinetic analysisPrincipal Investigator

    • Principal Investigator
      OHNISHI Yasuyuki
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Reliability of immuno deficient mice as a tool for preclinical antitumor drug evaluation

    • Principal Investigator
      YOSHIMURA Masumi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  自然耐性ヒト癌の耐性機構の解明とCPT-11耐性遺伝子を応用した遺伝子治療の試み

    • Principal Investigator
      安藤 俊夫
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Aichi Cancer Center Research Institute
  •  Studies on genetic and microbiologicail quality of human tumor xenografts lines as a tool for animal experimentsPrincipal Investigator

    • Principal Investigator
      OHNISHI Yasuyuki
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Expression of the Multidrug Resistance Gene (MDR1) and In Vivo Intrinsic Multidrug Resistance in Human Tumor Xenografts

    • Principal Investigator
      TAMAOKI Norikazu
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Tokai University

All 2005

All Journal Article

  • [Journal Article] Aberrant expression of the gastric mucin MUC6 in human pulmonary adenocarcinoma xenografts2005

    • Author(s)
      A.Hamamoto, H.Yamazaki, Y.Ohnishi, Y.Ueyama, M.Nakamura et al.
    • Journal Title

      International Journal of Oncology 26

      Pages: 891-896

    • Data Source
      KAKENHI-PROJECT-16300137
  • [Journal Article] S100A4 expression with reduced E-cadherin expression predicts distant metastasis of human malignant melanoma cell lines in NOD/SCID/γc^<null>(NOG) mouse model2005

    • Author(s)
      N.Ikoma, H.Yamazaki, Y.Ohnishi, Y.Ueyama, M.Nakamaura et al.
    • Journal Title

      Oncology Reports 14

      Pages: 633-637

    • Data Source
      KAKENHI-PROJECT-16300137
  • 1.  NAKAMURA Masato (00164335)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 1 results
  • 2.  HIOKI Kyoji (80208735)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  UEYAMA Yoshito (30072408)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 4.  ARAI Toshiro (70184257)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  TAMAOKI Norikazu (50055860)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  安藤 俊夫 (20012693)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  SUZUKI Hidekazu (70255454)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SAITO Yoshimasa (90360114)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  AKAIKE Toshihiro (30101207)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KANAI Yae (00260315)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YAMAMOTO Naoyuki (20250011)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  KATOH Hideki (30142053)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SUZUKI Shuzo (80113439)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TANIOKA Yoshikuni (10072406)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SUGIYAMA Yuichi (80090471)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  INABA Makoto (60085636)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  YOSHIMURA Masumi (40150867)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  ENDO Sachio (50203667)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  KURAMOCHI Takashi (10225253)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  MIZUSHIMA Tomoko (90311240)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  ITOH Kikuji (50100045)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  ITOH Toshio (20106644)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  NAKAYAMA Hiroyuki (40155891)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  KOBAYASHI Kimio (20205454)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  USUI Toshimi (10311234)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  OKADA Masaji (40160684)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  TOMISAWA Masashi (10321663)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  SUEMIZU Hiroshi (40332209)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  ITO Mamoru (00176364)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  NAKAHATA Tatsutoshi (20110744)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  TANAKA Yuetsu (30163588)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  KOYANAGI Yoshio (80215417)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  SUEMATSU Makoto (00206385)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  GODA Nobuhito (00245549)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  YAMAZAKI Hitoshi (20191273)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 36.  HASHIMOTO Haruo (30353478)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  TOBE Kazuyuki (30251242)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  石田 良司 (50150214)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  鬼島 宏 (90204859)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  平山 和宏 (60208858)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  江川 毅 (10232935)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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