Hirayama Kazuhiro 平山和宏

… Alternative Names

Researcher Number	60208858
Other IDs
Affiliation (Current)	2020: 東京大学, 大学院農学生命科学研究科(農学部), 教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 東京大学, 大学院農学生命科学研究科(農学部), 教授 2016 – 2017: 東京大学, 大学院農学生命科学研究科(農学部), 准教授 2012 – 2015: 東京大学, 農学生命科学研究科, 准教授 2011: 東京大学, 農学生命科学研究科, 助教 2008: 東京大学, 大学院・能楽生命科学研究科, 助教 … More
Review Section/Research Field	Principal Investigator Laboratory animal science / Applied veterinary science / Laboratory animal science / Integrated Nutrition Science Except Principal Investigator Laboratory animal science / Applied veterinary science / 基礎獣医学 / Laboratory animal science / Applied anthropology / Food science … More
Keywords	Principal Investigator 腸内菌叢 / ヒトフローラマウス / ヘテロサイクリックアミン / 無菌動物 / 無菌マウス / プロバイオティクス / ビフィズス菌 / ビフィズス菌増殖因子 / オリゴ糖 / 動物実験系 … More Except Principal Investigator 腸内フローラ / Intestinal flora / Gnotobiote / 腸内細菌 / c-Ha-ras / ノトバイオート / Bacteroides / SPFマウス / 腸内フロ-ラ / マウス / ラット / DMH / トランスジェニックマウス / Probiotics / p53 / Fusiform shaped bacteria / Bacteroidaseae / Clostridium / 16S rDNA / Lactobacillus / 低タンパク適応 / 栄養適応 / Campylobacter / Salmonella / 付着因子 / rasH2マウス / 1,2-dimethylhydrazine / アレー / 大腸ガン / 病態モデル / モニタリング / 病態モデル動物 / モニタリンガ / 病体モデス動物 / Campylobacter jejuni / ニワトリ / Campylobacte jejuni / <Campylobacter>___ー <jejuni>___ー / 嫌気性連続流動培養装置 / ニワトリフロ-ラマウス / 無菌マウス / Campylobactor jejuni / Chicken / SPFラット / ノトバイオ-ト / <Staphylococcus>___ー <qureus>___ー / SPF mouse / SPF rat / 実験動物 / ウサギ / Laboratory animal / C-Ha-rasマウス / 胆汁酸 / C-Ha-ras マウス / トランスジェニックマウス / 発ガン / Clostridium paraputriticum / C-Ha-ras / Colon cancer / Bile acids / Transgenic mice / ブタ / Pigs / VFA / Putrefactive products / 発癌 / rasマウス / Cancer / ras mice / transgenic mice / アフラトキシン / グルタチオンSトランスフェラーゼ / マストミス / ハムスター / グルタチオントランスフェラーゼ / アルデヒド / リダクターゼ / aflatoxin / glutathione-S-transferase / mastomys / hamster / mouse / rat / FISH法 / Lactobachillus / FISF法 / Fushiform shaped bactria / 16sDNA / Fushiform shaped bacteria / FISH method / ノ-トバイオ-ト / SPFモルモット / SPFウサギ / ノートバイオート / SPF guimea-pig / SPF rabbit / パプアニューギニア / lactic acid bacteria / intreferon-beta / small intestine / anti-inflammation / dendritic cell / Peyer's patch / Th1 / oral tolerance / 腸管免疫 / 乳酸菌 / 樹状細胞 / トル様レセプター３ (TLR３) / インターフェロン-β / インターロイキン-12 / 抗炎症 / 食品機能 / インターフェロンβ / 小腸常在菌 / トル様レセプター3: TLR3 / トル様レセプター３: TLR３) / 母乳 / 過酸化水素 / 腸内細菌叢 / 海馬 / 腸内細菌多様性 / ミエリン鞘 / 生理学 / 脳・神経 / ラオス / インドネシア / たんぱく / 細菌叢 / 歯周病 / 腸疾患 / 免疫 / 食物アレルギー / 生理活性脂質 / Gut Dyslipidosis Less

Investigation of intestinal lipid metabolism in food allergyOngoing
- Principal Investigator
  
  村田幸久
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section F
- Research Institution
  The University of Tokyo
人類の低タンパク適応メカニズムの固有性と普遍性Ongoing
- Principal Investigator
  
  梅崎昌裕
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 45060:Applied anthropology-related
- Research Institution
  The University of Tokyo
Crosstalk between oral and systemic responsesOngoing
- Principal Investigator
  
  東みゆき
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Tokyo Medical and Dental University
Studies on the relationship between brain function and gut microbiota determined by breast milk components
- Principal Investigator
  
  Nagaoka Kentaro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Challenging Research (Exploratory)
- Research Field
  
  Society medicine, Nursing, and related fields
- Research Institution
  Tokyo University of Agriculture and Technology
Low protein adaptation of humans
- Principal Investigator
  
  Umezaki Masahiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied anthropology
- Research Institution
  The University of Tokyo
Anti-inflammatory mechanism from small intestine to whole body via interferon-beta
- Principal Investigator
  
  Tsuji Noriko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Studies on the relationship between intestinal microbiota and obesityPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Kazuhiro
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  The University of Tokyo
Production of basic intestinal microflora for SPF mice using development of lesions of human desease modele mice as an indicator.
- Principal Investigator
  
  ITOH Kikuji
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
無菌動物技術を用いた大豆イソフラボン類の保健効果におけるヒト腸内菌叢の役割の解明Principal Investigator
- Principal Investigator
  
  平山和宏
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
RasH2マウスの高発癌性に関わる生理的バックグラウンドの研究
- Principal Investigator
  
  伊藤喜久治
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
The Study of Mechanisms of Aflatoxin Detoxification in Animals
- Principal Investigator
  
  KUMAGAI Susumu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  The University of Tokyo
Development of monitaruin system for intestinal flora of experimental animals using FISH method
- Principal Investigator
  
  ITOH Kikuji
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
ヒトフローラマウスを用いた発癌における食餌成分の発癌抑制効果の研究Principal Investigator
- Principal Investigator
  
  平山和宏
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
Study of control mechanisms of gene expression related to colorectal cancer by intestinal flora in rasH2 mice
- Principal Investigator
  
  ITOH Kikuji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
ノトバイオート技術を用いたヒト腸内細菌による胆汁酸代謝とその影響の研究Principal Investigator
- Principal Investigator
  
  平山和宏
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  The University of Tokyo
ヒトフローラマウスを用いた食品中の有害物質の腸内細菌による不活化の研究Principal Investigator
- Principal Investigator
  
  平田和宏
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  The University of Tokyo
ヒト腸内細菌叢と関連した発癌モデルのためのノトバイオートマウスの開発Principal Investigator
- Principal Investigator
  
  平山和宏
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
ビフィズス菌・ビフィズス菌増殖因子検定用動物としてのヒトフローラマウスの有用性Principal Investigator
- Principal Investigator
  
  平山和宏
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
Development of gnotobiote mice for cancer research
- Principal Investigator
  
  MITSUOKA Tomotari
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
Development of gnobotiotic mice for screening of efficiency of Probiotics
- Principal Investigator
  
  ITOH Kikuji
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
Ecological study of Bacteroides species habored in the intestine of laboratory animals.
- Principal Investigator
  
  ITOH Kikuji
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
CampylobacterとSalmonellaのニワトリ腸内定着因子の研究
- Principal Investigator
  
  ITOH Kikuji
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  The University of Tokyo
Studies on the elimination of Campylobacter jejuni from the intestine of chicken.
- Principal Investigator
  
  TAKAHASHI Eiji
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  The University of Tokyo
Standarization of mouse and rat intestinal flora, and development of preservation and monitaring methods for the intestinal flora.
- Principal Investigator
  
  MITSUOKA Tomotari
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
Production of specific pathogen-free(SPF)guinea-pigs and SPF rabbits by using gnotobiotes
- Principal Investigator
  
  MITSUOKA Tomotari
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo

All 2017 2016 2009 2008 2007 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] 乳酸菌と免疫恒常性2017
- Author(s)
  1.*辻　典子、平山和宏、安達貴弘
- Journal Title
  
  炎症と免疫
  
  Volume: 25 Pages: 34-41
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04504
[Journal Article] Visualization of Probiotic-Mediated Ca2+ Signaling in Intestinal Epithelial Cells In Vivo.2016
- Author(s)
  *Adachi T, Kakuta S, Aihara Y, Kamiya T, Watanabe Y, Osakabe N, Hazato N, Miyawaki A, Yoshikawa S, Usami T, Karasuyama H, Kimoto-Nira H, *Hirayama K, *Tsuji NM.
- Journal Title
  
  Front Immunol.
  
  Volume: 7 Pages: 601-601
- DOI
  10.3389/fimmu.2016.00601
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04504, KAKENHI-PROJECT-15K08526
[Journal Article] Intestinal Bifidobacterium association in germ-free T cell receptor transgenic mice down-regulates dietary antigen-specific immune responses of the small intestine but enhances those of large intestine2009
- Author(s)
  Tsuda, M., Hosono, A., Yanagibashi, T., Hachimura, S., Hirayama, K., Umesaki, Y., Itoh, K., Takahashi, K., Kaminogawa, S.
- Journal Title
  
  Immunobiology 214
  
  Pages: 279-289
- Data Source
  KAKENHI-PROJECT-18300138
[Journal Article] Competition for ploline between indigenous Escherichia coli, E. coli O157 : H7 in gnotobiotic mice associated with infant intestinal microbiota and its contribution to the colonization resistance against E. coli O157 : H72008
- Author(s)
  Momose, Y., Hirayama, K., Itoh, K.
- Journal Title
  
  Antonie van Leeuwenhoek 94
  
  Pages: 165-171
- Data Source
  KAKENHI-PROJECT-18300138
[Journal Article] Prior stimulation of antigen-presenting cells with Lactobacillus regulates excessive antigen-specific cytokine responses in vitro when compared with Bacteroides2008
- Author(s)
  Tsuda, M., Hosono, A., Yanagibashi, T., Hachimura, S., Hirayama, K., Itoh, K., Takahashi, K., Kaminogawa, S.
- Journal Title
  
  Cytotechnology 55
  
  Pages: 89-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300138
[Journal Article] Vitamin K deficiency of germfree mice caused by feeding standard purified diet sterilized by γirradiation.2007
- Author(s)
  Hirayama, K., Uetsuka, K., Kuwabara, Y., Tamura, M. & Itoh, K.
- Journal Title
  
  Exp. Anim. 56(4)
  
  Pages: 273-278
- NAID
  10019531978
- Data Source
  KAKENHI-PROJECT-18300138
[Journal Article] Human flora-associated(HFA) animals as a model for studing the role of intestinal flora in human health and diseases.2005
- Author(s)
  Hirayama, K., Itoh, K.
- Journal Title
  
  Curr.Issues Intestinal Microbiol. 6(印刷中)
- Data Source
  KAKENHI-PROJECT-14380379
[Journal Article] Muscularis inflammation and the loss of intestinal cells of Cajal in the endothelin ETB receptor null rat.2004
- Author(s)
  Suzuki, T., Won, K.J., Horiguchi, K., Kinoshita, K., Hori, M., Torihashi, S., Momotani, E., Itoh, K., Hirayama, K., Ward, S.M., Sanders, K.M., Ozaki, H.
- Journal Title
  
  Am.J.Physiol.Gastrintest.Liver Physiol. 287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380379
[Journal Article] Abnormal intestinal environment in rats with spontaneouse osinophilia (MES rat) : A possible new model for Studying Intestinal Putrefaction2003
- Author(s)
  Hirayama, K., Kouno, J., Itoh, K., Matsumoto, K.
- Journal Title
  
  Microbial Ecol. In Health and Dis. 15
  
  Pages: 57-62
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380379
[Journal Article] Abnormal intestinal environment in rats with spontaneous eosinophilia(MES rat) : A possible new model for studying intestinal putrefaction.2003
- Author(s)
  Hirayama, K., Kouno, J.Itoh, K., Matsumoto, K.
- Journal Title
  
  Microbial Ecology in Health and Disease 15
  
  Pages: 57-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380379
[Journal Article] Effect of organic acids on inhibition of Echerichia coli 0157: H7 colonization in gnotobiotic mice associated with infant intestinal microbiota.
- Author(s)
  Momose, Y. Hirayama, K. & Itoh, K.
- Journal Title
  
  Antonie van Leeuwenhoek (in press)
- Data Source
  KAKENHI-PROJECT-18300138
[Presentation] Adaptation to low-protein diet induced by transplantation of human microbiota in germfree mice.2017
- Author(s)
  Masuoka H, Umezaki M, Suda W, Tomitsuka E, Yamada A, Hirayama K.
- Organizer
  The 19th International Symposium on Gnotobiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04430
[Presentation] 「低タンパク適応」における腸内細菌叢の役割2017
- Author(s)
  増岡弘晃, 梅崎昌裕, 須田亙, 冨塚江利子, 山田章雄, 平山和宏
- Organizer
  第21回日本腸内細菌学会
- Data Source
  KAKENHI-PROJECT-15H04430
[Presentation] 腸内細菌による宿主代謝変化の解析－低タンパク適応機構の解明2016
- Author(s)
  冨塚江利子, 増岡　弘晃, 須田亙, 猪飼桂, 田所聖志, 馬場淳, 森田彩子, 内藤裕一, Paul Horwood, Andrew Greenhill, Peter Siba, 小谷真吾, 夏原和美, 服部正平, 森田英利, 平山　和宏, 梅崎昌裕．
- Organizer
  第39回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H04430

1. ITOH Kikuji (50100045)

# of Collaborated Projects: 11 results

# of Collaborated Products: 9 results
2. MITSUOKA Tomotari (30157549)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. ITOH Tishio (20106644)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. TAKAHASHI Eiji (50183439)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. Umezaki Masahiro (30292725)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. 須田亙 (20590847)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. 冨塚江利子 (90313098)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. URANO Touru (90101899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKAKURA Akira (60167484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MAEJIMA Kazuyoshi (70051464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. GOTO Naoaki (70011989)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HIOKI Kyouji (80208735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NOMURA Tatsuji (10072399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TERADA Atsushi (10060518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. UEMURA Takeshi (40081591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SAWAZAKI Touru (00012047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NAKAYAMA Hiroyuki (40155891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KOBAYASHI Kimio (20205454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. OHNISHI Yasuyuki (70201382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KUMAGAI Susumu (60109965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. DOI Kunio (70155612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SUEMIZU Youji (40332209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NAKAGAWA Masarou (90072892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SUDO Katsuko (50126091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. Tsuji Noriko (30343990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
26. Nagaoka Kentaro (60376564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 河村晴次 (10161366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 塩田邦郎 (80196352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 角田茂 (80345032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
30. 高安伶奈 (20814833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 東みゆき (90255654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 竹内康雄 (60396968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 村田幸久 (40422365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 伏信進矢 (00302589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 山本貴和子 (40725115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 堀正敏 (70211547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. TANAKA Toshio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. Benno Yoshimi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 安達貴弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirayama Kazuhiro 平山 和宏

HIRAYAMA Kazuhiro 平山 和宏

平山 和宏 ヒラヤマ カズヒロ

平田 和宏 ヒラタ カズヒロ

Research Projects

Research Products

Co-Researchers

Investigation of intestinal lipid metabolism in food allergyOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

人類の低タンパク適応メカニズムの固有性と普遍性Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Crosstalk between oral and systemic responsesOngoing

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Review Section

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Principal Investigator

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Research Category

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Principal Investigator

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Studies on the relationship between intestinal microbiota and obesityPrincipal Investigator

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無菌動物技術を用いた大豆イソフラボン類の保健効果におけるヒト腸内菌叢の役割の解明Principal Investigator

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Research Field

Research Institution

ヒトフローラマウスを用いた発癌における食餌成分の発癌抑制効果の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Hirayama Kazuhiro 平山和宏

HIRAYAMA Kazuhiro 平山和宏

平山和宏ヒラヤマカズヒロ

平田和宏ヒラタカズヒロ