CHIBA Kan 千葉寛

… Alternative Names

Researcher Number	40159033
External Links
Affiliation (based on the past Project Information) *help	2012 – 2015: 千葉大学, 薬学研究科(研究院), 教授 2009 – 2012: Chiba University, 大学院・薬学研究院, 教授 2006: 千葉大学, 大学院薬学研究院, 教授 2003 – 2005: 千葉大学, 大学院・薬学研究院, 教授 1996 – 1999: Faculty of Pharmaceutical Sciences, Lab.of Biochem.Phamacol.and Bioloxycol.Chiba, 薬学部, 教授 1995: 国立国際医療センター, 研究所・臨床薬理部, 室長 1989: 国立病院医療センター, 臨床研究部, 室長
Review Section/Research Field	Principal Investigator Medical pharmacy / 応用薬理学・医療系薬学 Except Principal Investigator 応用薬理学・医療系薬学 / Physical pharmacy / Conservative dentistry
Keywords	Principal Investigator 薬物代謝 / PXR / CAR / 応用動物 / ヒトの薬物動態・代謝予測系 / 薬学 / 評価系 / 予測 / CYP2C9 / CYP2C18 … More Except Principal Investigator 薬物代謝 / P450 / in vitro / microsome / メフェニトイン / チトクロムPー450 / ポリモルフィズム / ジアゼパム / 体内動態 / 薬物相互作用 / 酵素阻害 / 酵素誘導 / ヒトCYP発現系 / drug interaction / enzyme inhibition / recombinant human CYP isoforms / enzyme induction / 肝ミクロソーム / P450発現系 / 輸送担体 / 肝取り込み / 胆汁排泄 / 胆管側膜小胞 / 能動輸送 / drug metabolism / hepatic microsomes / recombinant P-450 / transporter / hepatic uptake / biliary excretion / ニフェジピン / 歯肉増殖 / プロテオグリカン / 歯肉線維芽細胞 / リボポリサッカライド / サイトカイン / インターロイキン-4 / コンドロイチン硫酸プロテオグリカン / ヘパラン硫酸プロテオグリカン / 歯肉肥大 / 高血圧 / Nifedipine / Gingival hyperplasia / Proteoglycan / Gingival fibroblast / Lipopolysaccharide / Cytokine Less

Study on the exosomes as a biomarker to estimate in vivo function of human blood-brain barrierPrincipal Investigator
- Principal Investigator
  
  Chiba Kan
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Establishment of in vitro and in vivo models for human CES which promote rational development of ester-based prodrugsPrincipal Investigator
- Principal Investigator
  
  Chiba Kan
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
A challenge to construct human mini liver using temperature sensitive immortalized human liver cellsPrincipal Investigator
- Principal Investigator
  
  KAN Chiba
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Creation of CYP3A- and P-glycoprotein-humanized mouse and its application to the study of drug metabolism and dispositionPrincipal Investigator
- Principal Investigator
  
  CHIBA Kan
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
スティーブンス・ジョーンソン症候群モデルマウス創製の試みPrincipal Investigator
- Principal Investigator
  
  千葉寛
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
特定の培養液によりCYP3A4mRNAが30倍増加する機構の解明Principal Investigator
- Principal Investigator
  
  千葉寛
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Identification of hepatic genes regulated in early phase of cholestasis by cDNA microarray analysis in ratsPrincipal Investigator
- Principal Investigator
  
  CHIBA Kan
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Gene polymorphism of CYP2C subfamily and inter-individual differences in drug metabolismPrincipal Investigator
- Principal Investigator
  
  CHIBA Kan
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
Cytological and pharmacological studies on the pathogenesis of nifedipine-associated gingival hyperplasia
- Principal Investigator
  
  NOGUCHI Kazuyuki, 魚島マリコ
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Tokyo Medical and Dental University
Development of a method to predict in vivo drug metabolism and excretion from in vitro data with human hepatic tissues and/or recombinant proteins
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Graduate School of Pharmaceutical Sciences, The University of Tokyo
Development of in vitro screening system for CYP based drug interaction
- Principal Investigator
  
  HAYASHI Masahiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Faculty of Pharmaceutical Sciences, Science University of Tokyo
日本人の薬物反応個体差とメフェニトイン型チトクロムPー450欠損症
- Principal Investigator
  
  ISHIZAKI Takashi
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Research Institute, International Medical Center of Japan

All 2015 2014 2013 2010

All Journal Article Presentation

[Journal Article] Perspective of humanized mouse models for assessing PK/PD and toxic profile of drug candidates in preclinical study.2014
- Author(s)
  Kan Chiba
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 29 Pages: 1-2
- NAID
  130004463339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293035
[Journal Article] Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans2013
- Author(s)
  Kazuki Y, Kobayashi K, Aueviriyavit S, Oshima T, Kuroiwa Y, Tsukazaki Y, Senda N, Kawakami H, Ohtsuki S, Abe S, Takiguchi M, Hoshiya H, Kajitani N, Takehara S, Kubo K, Terasaki T, Chiba K, Tomizuka K, Oshimura M.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 22(3) Pages: 578-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390040
[Journal Article] Species differences in mechanism-based inactivation of CYP3A in humans, rats and2010
- Author(s)
  Aueviriyavit S, Kobayashi K, Chiba K.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 25(1) Pages: 93-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390040
[Presentation] ヒト血液脳関門コリントランスポーターの同定とその血液脳関門機能における役割の解明2015
- Author(s)
  鈴木翔太、降幡知巳、伊藤涼、周徐嘉、稲津正人、千葉寛
- Organizer
  第10回トランスポーター研究会
- Place of Presentation
  東京
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-26670072
[Presentation] Identification and functional characterization of human blood-brain barrier choline transporter in HBMEC/ciβ, an immortalized human brain microvascular endothelial cell line.2015
- Author(s)
  Ito R, Furihata T, Suzuki S, Chiba K.
- Organizer
  11th Cerebrovascular biology
- Place of Presentation
  Paris, France
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670072
[Presentation] (2) FUNCTIONAL EXPRESSION OF HUMAN CYP3A ISOFORMS IN CYP3A-HAC MICE AND INHIBITION OF CYP3A VIA MECHHANISM -BASED INACTIVATION(ポスター発表) 9th Interntional ISSX Meeting ・Istanbul Turkey・2010
- Author(s)
  Mio Watanabe, Sasitorn Aueviriyavit, Kaoru Kobayashi, Nahoko Iuchi, Yasuhiro kazuki,Mitsuo Oshimura and Kan Chiba HUMANIZED CYP3A MICE
- Data Source
  KAKENHI-PROJECT-21390040

1. KOBAYASHI Kaoru (30255864)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. FURIHATA Tomomi (80401008)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
3. KAZUKI Yasuhiro (90403401)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
4. ISHIZAKI Takashi (50158747)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. HOSOKAWA Masakiyo (70181500)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. NOGUCHI Kazuyuki (90218298)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. IMAI Teruko (70176478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HAYASHI Masahiro (20012669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OKUDAIRA Kazuho (30204134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SUGIYAMA Yuichi (80090471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TAKIGAWA Hajime (70197226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KATO Yukio (30251440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SUZUKI Hiroshi (80206523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TERASAKI Tetsuya (60155463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KITADA Kouichi (90110345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YANAGISHITA Masaki (70132793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 魚島マリコ (50228425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KUBOTA Takahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

CHIBA Kan 千葉 寛

千葉 寛 チバ カン

Research Projects

Research Products

Co-Researchers

Study on the exosomes as a biomarker to estimate in vivo function of human blood-brain barrierPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of in vitro and in vivo models for human CES which promote rational development of ester-based prodrugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A challenge to construct human mini liver using temperature sensitive immortalized human liver cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Creation of CYP3A- and P-glycoprotein-humanized mouse and its application to the study of drug metabolism and dispositionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

スティーブンス・ジョーンソン症候群モデルマウス創製の試みPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

特定の培養液によりCYP3A4mRNAが30倍増加する機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of hepatic genes regulated in early phase of cholestasis by cDNA microarray analysis in ratsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene polymorphism of CYP2C subfamily and inter-individual differences in drug metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cytological and pharmacological studies on the pathogenesis of nifedipine-associated gingival hyperplasia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a method to predict in vivo drug metabolism and excretion from in vitro data with human hepatic tissues and/or recombinant proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of in vitro screening system for CYP based drug interaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

日本人の薬物反応個体差とメフェニトイン型チトクロムPー450欠損症

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Perspective of humanized mouse models for assessing PK/PD and toxic profile of drug candidates in preclinical study.2014

Author(s)

Journal Title

CHIBA Kan 千葉寛

千葉寛チバカン