hosokawa masakiyo 細川正清

… Alternative Names

HOSOKAWA Masakiyo 細川正清

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Researcher Number	70181500
Other IDs
External Links
Affiliation (Current)	2025: 千葉科学大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2012 – 2018: 千葉科学大学, 薬学部, 教授 2005: Chiba Institute of Science, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 2002 – 2005: 千葉大学, 大学院・薬学研究院, 助教授 2000 – 2001: 千葉大学, 薬学部, 助教授 1997 – 1999: 千葉大学, 薬学部, 講師 1993 – 1995: 千葉大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator 医薬分子機能学 / Medical pharmacy / Drug development chemistry Except Principal Investigator 医薬分子機能学 / Medical pharmacy / 応用薬理学・医療系薬学
Keywords	Principal Investigator カルボキシルエステラーゼ / エステラーゼ / carboxylesterase / プロドラッグ / EBP / C / Sp1 / inverted duplication / GC-Box / ヒト肝 … More / PON / 血管内皮細胞 / 薬物代謝酵素 / cDNAクローニング / ヒト脳 / アトルバスタチン / ヒト小腸ミクロソーム / ヒト肝ミクロソーム / 臓器特異的発現機構 / 代謝酵素 / CES2A1 / CES1A1 / ハロペリドールプロドラッグ / インドメタシンプロドラッグ / アトルバスタチンプロドラッグ / 臓器特異的 / individual differences / human liver / promoter / regulation mechanism / EBR / プロモーター / 個人差 / 発現調節機構 / transfactor / genome / transcriptional mechanism / species differences / capillary endothelial cells / 転写因子 / ゲノム / 転写調節機構 / 種差 / 脳毛細血管内皮細胞 / esterase / prudrug / drug metabolism / cDNA cloning / Human brain / KDEL レセプター / cDNA クローニング / 薬物代謝 / CES / アリルアセトアミドデアセチラーゼ / ブチリルコリンエステラーゼ / パラオクソナーゼ / AADAC / 代謝活性化 … More Except Principal Investigator CYP2C19 / CYP2C18 / CYP2C9 / カルボキシルエステラーゼ / プロドラッグ / cluster analysis / gene expression / cholestasis / microarray / TNFα / SHP / CAR / PXR / OAT3 / cDNAマイクロアレイ / クラスター解析 / 遺伝子発現 / 胆汁うっ滞 / マイクロアレイ / Isoform / Liver microsomes / Intestinal microsomes / Drug design / Ester bond / Hydrolysis / Prodrug / Carboxylesterase / 発現系 / 肝臓ミクロソーム / 小腸ミクロソーム / 分子設計 / エステル結合 / 加水分解 / linkage / inter-individual differences / Polymorphism / 連鎖 / 個人差 / 多型 / drug metabolism / esterase / CO57 cells / CYP 450 / glutathion S-transferase / carboxyl esterase / グルタチオン S-トランスフェラーゼ / P450 / 培養細胞 / 発現 / 遺伝子導入 / 薬物代謝酵素 / グルタチオンS-トランスフェラーゼ / CYP / エステラーゼ / 予測 / 評価系 / 評価 / ヒト予測 / CES / 試験系 / 薬物代謝 Less

Organ-specific expression of prodrug converting enzyme and construction of metabolic model cell linePrincipal Investigator
- Principal Investigator
  
  Hosokawa Masakiyo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba Institute of Science
Establishment of in vitro and in vivo models for human CES which promote rational development of ester-based prodrugs
- Principal Investigator
  
  Chiba Kan
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Molecular mechanism of the tissue-specific expression of the hydrolases which enzymes related to structure activity relationship of pro-drugsPrincipal Investigator
- Principal Investigator
  
  HOSOKAWA Masakiyo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba Institute of Science
Individual differences of the regulation mechanism of the human carboxylesterase genePrincipal Investigator
- Principal Investigator
  
  HOSOKAWA Masakiyo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Chiba Institute of Science
  Chiba University
Identification of hepatic genes regulated in early phase of cholestasis by cDNA microarray analysis in rats
- Principal Investigator
  
  CHIBA Kan
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Species differences in the regulation mechanisms between human and mouse carboxylesterase genesPrincipal Investigator
- Principal Investigator
  
  HOSOKAWA Masakiyo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  CHIBA UNIVERSITY
Ratinal design of drags containing ester bond based on carboxylesterase activity
- Principal Investigator
  
  IMAI Teruko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  KUMAMOTO UNVERSITY
Gene polymorphism of CYP2C subfamily and inter-individual differences in drug metabolism
- Principal Investigator
  
  CHIBA Kan
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
Molecular aspect of drug transport and metabolism by brain carboxylesterases in rats and humansPrincipal Investigator
- Principal Investigator
  
  HOSOKAWA Masakiyo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  CHIBA UNIVERSITY
ヒト脳血管内皮細胞に局在するエステラーゼを介する薬物透過の分子機構Principal Investigator
- Principal Investigator
  
  細川正清
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Chiba University
Studies on the metabolism and toxicity of drugs using mammalian cells expressed in drug metabolism enzymes
- Principal Investigator
  
  SATOH Tetsuo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Chiba University

All 2019 2018 2017 2016 2015 2014 2013 2012 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] 9.1.5「異物代謝に影響を及ぼす因子」衛生薬学　第6版（編集永沼章、姫野誠一郎、平塚明）2018
- Author(s)
  細川正清
- Total Pages
  538
- Publisher
  丸善出版
- ISBN
- Data Source
  KAKENHI-PROJECT-16K08378
[Book] 2.2.2.ｃ「カルボキシルエステラーゼ」医療薬物代謝学　第2版（編集　山崎浩史、小澤正吾）2018
- Author(s)
  細川正清
- Total Pages
  116
- Publisher
  テコム
- ISBN
- Data Source
  KAKENHI-PROJECT-16K08378
[Book] 医療薬物代謝学第2版2018
- Author(s)
  細川正清他5名（山崎浩史、小沢正吾編集）
- Total Pages
  116
- Publisher
  テコム出版事業部
- ISBN
  9784863994126
- Data Source
  KAKENHI-PROJECT-16K08378
[Book] 薬学領域の病原微生物学・感染症学・化学療法学2018
- Author(s)
  細川正清他{増澤俊幸、河村好章編集）
- Total Pages
  497
- Publisher
  廣川書店
- ISBN
  9784567521338
- Data Source
  KAKENHI-PROJECT-16K08378
[Book] 衛生薬学第6版2018
- Author(s)
  細川正清他（永沼章、姫野誠一郎、平塚明編集）
- Total Pages
  538
- Publisher
  丸善出版
- ISBN
  9784621301784
- Data Source
  KAKENHI-PROJECT-16K08378
[Book] スタンダード薬学シリーズII第6巻医療薬学IV　薬の生体内運命2016
- Author(s)
  細川正清
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-16K08378
[Book] コンパス生物薬剤学改訂第二版（編集：岩城正宏、伊藤智夫）2016
- Author(s)
  細川正清
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-16K08378
[Book] 薬学領域の病原微生物学・感染症学・化学療法学　第3版2016
- Author(s)
  細川正清
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-16K08378
[Book] 薬剤学実験法必携マニュアルII生物薬剤学　第5章薬物代謝実験2014
- Author(s)
  細川正清　他56名
- Total Pages
  423
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-24590206
[Book] 酵素誘導実験　薬剤学実験法必携マニュアルII生物薬剤学（日本薬剤学会編集委員会編）2014
- Author(s)
  細川正清
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-24590206
[Book] 9章1-5異物代謝に影響を及ぼす因子　衛生薬学-健康と環境-（永沼章、姫野誠一郎、平塚明編）2014
- Author(s)
  細川正清
- Publisher
  丸善出版
- Data Source
  KAKENHI-PROJECT-24590206
[Book] 衛生薬学　　第9章　化学物質と毒性2013
- Author(s)
  細川正清　他22名
- Total Pages
  503
- Publisher
  丸善出版
- Data Source
  KAKENHI-PROJECT-24590206
[Book] 衛生薬学　第9章化学物質と毒性2013
- Author(s)
  細川正清　他25名
- Total Pages
  503
- Publisher
  丸善出版
- Data Source
  KAKENHI-PROJECT-24590206
[Book] Toxicology of Organophosphate and Carbamate Compounds2005
- Author(s)
  Hosokawa M, Satoh T
- Total Pages
  763
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-16590081
[Book] Function and regulation of carboxylesterase In "Toxicology of Organophosphate & Carbamate Compounds" (Ed. Ramesh C. Gupta)2005
- Author(s)
  Hosokawa M, Satoh T
- Total Pages
  763
- Publisher
  ELSEVIER
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Synthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesterase.2019
- Author(s)
  Takahashi M, Uehara T, Nonaka M, Minagawa Y, Yamazaki R, Haba M, Hosokawa M.
- Journal Title
  
  Eur J Pharm Sci.
  
  Volume: 132 Pages: 125-131
- DOI
  10.1016/j.ejps.2019.03.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08378, KAKENHI-PROJECT-17K15519
[Journal Article] Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver.2018
- Author(s)
  Uno Y, Igawa Y, Tanaka M, Ohura K, Hosokawa M, Imai T.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中 Issue: 2 Pages: 247-255
- DOI
  10.1080/00498254.2018.1435927
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08378
[Journal Article] hemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 12018
- Author(s)
  Takahashi M, Ogawa T, Kashiwagi H, Fukushima F, Yoshitsugu M, Haba M, Hosokawa M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 28 Pages: 997-1000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08378
[Journal Article] Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies2018
- Author(s)
  Ishizaki Y, Furihata T, Oyama Y, Ohura K, Imai T, Hosokawa M, Akita H, Chiba K.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 5 Pages: 697-706
- DOI
  10.1248/bpb.b17-00880
- NAID
  130006730737
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-05-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08378
[Journal Article] Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1.2018
- Author(s)
  Takahashi M, Ogawa T, Kashiwagi H, Fukushima F, Yoshitsugu M, Haba M, Hosokawa M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 28 Issue: 6 Pages: 997-1000
- DOI
  10.1016/j.bmcl.2018.02.035
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08378, KAKENHI-PROJECT-17K15519
[Journal Article] Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques.2018
- Author(s)
  Uno Y, Uehara S, Mahadhi HMD, Ohura K, Hosokawa M, Imai T.
- Journal Title
  
  J Med Primatol.
  
  Volume: 47 Issue: 3 Pages: 185-191
- DOI
  10.1111/jmp.12342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08378, KAKENHI-PROJECT-17K15520
[Journal Article] Functional Analysis of Carboxylesterase in Human Induced Pluripotent Stem Cell-derived Enterocytes.2017
- Author(s)
  Kabeya T, Matsumura W, Iwao T, Hosokawa M, Matsunaga T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 486 Issue: 1 Pages: 143-148
- DOI
  10.1016/j.bbrc.2017.03.014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293036, KAKENHI-PROJECT-15K18929, KAKENHI-PROJECT-16K08378, KAKENHI-PROJECT-16K15164, KAKENHI-PROJECT-16H01811, KAKENHI-PROJECT-17K08421
[Journal Article] Functional analysis of carboxylesterase in human induced pluripotent stem cell-derived enterocytes.2017
- Author(s)
  Kabeya, T., Matsumura, W., Iwao, T., Hosokawa, M., and Matsunaga, T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 486 Pages: 143-148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08378
[Journal Article] Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side Effects.2017
- Author(s)
  Toshimoto K, Tomaru A, Hosokawa M, Sugiyama Y.
- Journal Title
  
  Pharm Res
  
  Volume: 印刷中 Issue: 8 Pages: 1584-1600
- DOI
  10.1007/s11095-017-2153-z
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-16K08378, KAKENHI-PROJECT-16K18972
[Journal Article] Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases.2016
- Author(s)
  Mizoi K, Takahashi M, Haba M, Hosokawa M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 26 Issue: 3 Pages: 921-923
- DOI
  10.1016/j.bmcl.2015.12.069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293035, KAKENHI-PROJECT-16K08378
[Journal Article] Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques2015
- Author(s)
  Uno Y, Hosokawa M, Imai T
- Journal Title
  
  J Vet Med Sci
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590206
[Journal Article] Systematic identification andcharacterization of carboxylesterases in cynomolgus macaques.2014
- Author(s)
  Uno Y Uehara S, Hosokawa M, Imai T
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 42 Issue: 12 Pages: 2002-2006
- DOI
  10.1124/dmd.114.059972
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590206, KAKENHI-PROJECT-24590660, KAKENHI-PROJECT-25293035
[Journal Article] The effect of carboxylesterase 1 (CES1) polymorphisms on the pharmacokinetics of oseltamivir in humans.2013
- Author(s)
  Suzaki Yuki
- Journal Title
  
  Eur J Clin Pharmacol.
  
  Volume: 69(1) Issue: 1 Pages: 21-30
- DOI
  10.1007/s00228-012-1315-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790604, KAKENHI-PROJECT-24590206
[Journal Article] Gly143Glu polymorphism of the human carboxylesterase1 gene in an Asian population.2013
- Author(s)
  Suzaki Yuki
- Journal Title
  
  Eur J Clin Pharmacol.
  
  Volume: 69(3) Issue: 3 Pages: 735-736
- DOI
  10.1007/s00228-012-1352-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790604, KAKENHI-PROJECT-24590206
[Journal Article] Dexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 gene2012
- Author(s)
  Hori T, Jin L, Fujii A, Furihata T, Nagahara Y, Chiba K, Hosokawa M.
- Journal Title
  
  Xenobiotica
  
  Volume: 42 Issue: 7 Pages: 614-623
- DOI
  10.3109/00498254.2011.648670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590206
[Journal Article] Hepatocyte nuclear factor-4 alphaplays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver2006
- Author(s)
  Furihata T, Hosokawa M, Masuda M, Satoh T, Chiba K
- Journal Title
  
  Arch. Biophys. Biochem, 447
  
  Pages: 107-117
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Hepatocyte nuclear factor-4 alphaplays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver,2006
- Author(s)
  Furihata T, Hosokawa M, Masuda M, Satoh T, Chiba K
- Journal Title
  
  Arch.Biophys.Biochem 447
  
  Pages: 107-117
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Hepatocyte nuclear factor-4 alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver2006
- Author(s)
  Furihata T, Hosokawa M, Masuda M, Satoh T, Chiba K
- Journal Title
  
  Arch.Biophys.Biochem. (印刷中)
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Involvement of hepatocyte nuclear factor 4a in the different expression level between CYP2C9 and CYP2C19 in the human liver2006
- Author(s)
  Kawashima S, Kobayashi K, Takama K, Furihata T, Higuchi T, Hosokawa M, Chiba K
- Journal Title
  
  Drug Metab.Dispos. (印刷中)
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Identification of HMG-CoA reductase inhibitors as activators for human, mouse of rat constitutive androstane receptor (CAR)2005
- Author(s)
  Kobayashi K, Yamanaka Y, Iwazaki N, Nakajio I, Hosokawa M, Negishi M, Chiba K
- Journal Title
  
  Drug. Metab. Dispos. 33
  
  Pages: 924-929
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1^*5, SLCO1B1^*15 and SLCO1B1^*15+C1007G, by using transient expression systems of HeLa and HEK293 cells2005
- Author(s)
  Kameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K
- Journal Title
  
  Pharmacogenetics and Genomics 15
  
  Pages: 513-522
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Dexamethasone-induced methylprednisolone hemisuccinate hydrolase : Its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma2005
- Author(s)
  Furihata T, Hosokawa M, Fujii A, Derbel M, Satoh T, Chiba K
- Journal Title
  
  Biochem.Pharmacol. 69
  
  Pages: 1287-1297
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor (CAR)2005
- Author(s)
  Kobayashi K, Yamanaka Y, Iwazaki N, Nakajio I, Hosokawa M, Negishi M, Chiba K
- Journal Title
  
  Drug.Metab.Dispos 33
  
  Pages: 924-929
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] バイオ人工肝-実用化のための基本的な条件2005
- Author(s)
  永森靜志, 小田裕昭, 宮崎正博, 秋山一郎, 細川正清, 千葉寛, 相崎英樹, 村上恭子, 鈴木哲朗
- Journal Title
  
  胆肝膵, 51
  
  Pages: 107-120
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Dexamethasone-induced methylprednisolone hemisuccinate hydrolase : Its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma.2005
- Author(s)
  Furihata T, Hosokawa M, Fujii A, Derbel M, Satoh T, Chiha K
- Journal Title
  
  Biochem.Pharmacol 印刷中
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5,SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells2005
- Author(s)
  ameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K
- Journal Title
  
  Pharmacogenet Genomics
  
  Pages: 513-522
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Dexamethasone-induced methylprednisolone hemisuccinate hydrolase : Its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma2005
- Author(s)
  Furihata T, Hosokawa M, Fujii A, Derbel M, Satoh T, Chiba K
- Journal Title
  
  Biochemical Pharmacology 69
  
  Pages: 1287-1297
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCOIB1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells.2005
- Author(s)
  Kameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K
- Journal Title
  
  Pharmacogenet Genomics.
  
  Pages: 513-522
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Structure, function and regulation of carboxylesterase2005
- Author(s)
  Hosokawa M, Satoh T
- Journal Title
  
  Toxicology of Organophosphate & Carbamate Compounds(Ed.Ramesh C.Gupta)(ELSEVIER)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Dexamethasone-induced methylprednisolone hemisuccinate hydrolase : Its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma2005
- Author(s)
  Furihata T, Hosokawa M, Fujii A, Derbel M, Satoh T, Chiba
- Journal Title
  
  Biochem. Pharmacol 69
  
  Pages: 1287-1297
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor (CAR)2005
- Author(s)
  Kobayashi K, Yamanaka Y, Iwazaki N, Nakajio I, Hosokawa M, Negishi M, Chiba K
- Journal Title
  
  Drug.Metab.Dispos. 33
  
  Pages: 924-929
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Synergistic role of specificity proteins and upstream stimulatory factor 1 in transactivation of the mouse carboxylesterase 2/microsomal acylcarnitine hydrolase gene promoter.2004
- Author(s)
  Furihata T, Hosokawa M, Satoh T, Chiba K.
- Journal Title
  
  Biochem J. 384
  
  Pages: 101-110
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] 抗癌剤の選択とPharmacogenomics2004
- Author(s)
  細川正清
- Journal Title
  
  THE LUNG perspective 12(3)
  
  Pages: 292-303
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Synergistic role of specificity proteins and upstream stimulatory factor 1 in transactivation of the mouse carboxylesterase 2/microsomal acylcarnitine hydrolase gene promoter.2004
- Author(s)
  Furihata T, Hosokawa M, Satoh T, Chiba K.
- Journal Title
  
  Biochem J. 384(Pt1)
  
  Pages: 101-110
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.2004
- Author(s)
  Hirota T, Ieiri I, Takane H, Maegawa S, Hosokawa M, Kobayashi K, Chiba K, Nanba E, Oshimura M, Sato T, Higuchi S, Otsubo K.
- Journal Title
  
  Hum Mol Genet. 13(23):
  
  Pages: 2959-2969
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.2004
- Author(s)
  Hirota T, Ieiri I, Takane H, Maegawa S, Hosokawa M, Kobayashi K, Chiba K, Nanba
- Journal Title
  
  Hum Mol Genet. 13(23):
  
  Pages: 2959-2969
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.2004
- Author(s)
  Hirota T, Ieiri I, Takane H, Maegawa S, Hosokawa M, Kobayashi K, Chiba K, Nanba E, Oshimura M, Sato T, Higuchi S, Otsubo K.
- Journal Title
  
  Hum Mol Genet. 13(23)
  
  Pages: 2959-2969
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Expression of CYP3A4 by an immortalized human hepatocyte line in a three-dimensional culture using a radial-flow bioreactor2004
- Author(s)
  Akiyama I, Tomiyama K, Sakaguchi M, Takaishi M, Mori M, Hosokawa M, 他
- Journal Title
  
  International J Mol Med. 14(4):
  
  Pages: 663-668
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] A noel variant allele of OATP-C(SLCO1B1) found in a Japanese patient with pravastatin0induced myopathy2004
- Author(s)
  Morimoto K, Oishi T, Ueda S, Ueda M, Hosokawa M, Chiba K
- Journal Title
  
  Drug Metab. Pharmacokinet 19(6)
  
  Pages: 453-455
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] エステラーゼの遺伝子多型と臨床検査2004
- Author(s)
  細川正清, 千葉寛
- Journal Title
  
  臨床検査 48
  
  Pages: 183-193
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Expression of CYP3A4 by an immortalized human hepatocyte line in a three-dimensional culture using a radial-flow bioreactor.2004
- Author(s)
  Akiyama I, Tomiyama K, Sakaguchi M, Takaishi M, Mori M, Hosokawa M, 他
- Journal Title
  
  International J Mol Med. 14(4):
  
  Pages: 663-668
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL/6 mouse liver microsomes : purification, cDNA cloning, and baculovirus-mediated expression.2004
- Author(s)
  Furihata T, Hosokawa M, Koyano N, Nakamura T, Satoh T, Chiba K.
- Journal Title
  
  Drug Metab Dispos. 32(10)
  
  Pages: 1170-1177
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Key structural features of ligands for activation of human pregnane X receptor.2004
- Author(s)
  Kobayashi K, Yamagami S, Higuchi T, Hosokawa M, Chiba K.
- Journal Title
  
  Drug Metab Dispos 32(4):
  
  Pages: 468-472
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] Key structural features of ligands for activation of human pregnane X receptor.2004
- Author(s)
  Kobayashi K, Yamagami S, Higuchi T, Hosokawa M, Chiba K.
- Journal Title
  
  Drug Metab Dispos. 32(4)
  
  Pages: 468-472
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Journal Article] A noel variant allele of OATP-C(SLCO1B1) found in a Japanese patient with pravastatin induced myopathy2004
- Author(s)
  Morimoto K, Oishi T, Ueda S, Ueda M, Hosokawa M, Chiba K
- Journal Title
  
  Drug Metab.Pharmacokinet. 19(6)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590081
[Presentation] インドメタシンプロドラッグの合成とカルボキシルエステラーゼ1による代謝活性化2018
- Author(s)
  高橋正人、小川悌央、柏木裕史、福島史也、吉次美咲、巾正美、細川正清
- Organizer
  日本薬学会第138年会、金沢2018.3
- Data Source
  KAKENHI-PROJECT-16K08378
[Presentation] Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 12018
- Author(s)
  Masato Takahashi, Tomohiro Ogawa, Hiroshi Kashiwagi, Fumiya Fukushima, Misaki Yoshitsugu, Masami Haba, Masakiyo Hosokawa.
- Organizer
  International Symposium on MDO and the 33rd Annual Meeting of JSSX, Kanazawa, Japan, 2018.10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08378
[Presentation] 様々な構造および電子的特徴を持つアトルバスタチンエステルを用いたマウス、カニクイザルおよびヒトカルボキシルエステラーゼ活性の種差2018
- Author(s)
  堺早知子、溝井健太、高橋正人、巾正美、宇野　泰宏、今井　輝子、細川正清
- Organizer
  日本薬学会第138年会、金沢2018.3
- Data Source
  KAKENHI-PROJECT-16K08378
[Presentation] ヒトiPS細胞由来腸管上皮細胞におけるカルボキシルエステラーゼの機能解析2017
- Author(s)
  壁谷知樹、松村若菜、岩尾岳洋、細川正清、松永民秀
- Organizer
  日本薬学会第137年会仙台
- Data Source
  KAKENHI-PROJECT-16K08378
[Presentation] カルボキシルエステラーゼにより代謝活性化されるアトルバスタチンプロドラッグの設計2017
- Author(s)
  堺早知子、溝井健太、高橋正人、巾正美、細川正清
- Organizer
  日本薬学会第137年会仙台
- Data Source
  KAKENHI-PROJECT-16K08378
[Presentation] エステル型プロドラッグ消化管吸収評価能の向上に向けたヒト小腸型CES発現Caco-2細胞の樹立2017
- Author(s)
  石崎裕馬、降幡知巳、大浦華代子、今井輝子、細川正清、秋田英万
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16K08378
[Presentation] カルボキシルエステラーゼにより代謝活性化されるアトルバスタチンプロドラッグの設計2017
- Author(s)
  堺早知子、溝井健太、高橋正人、巾正美、細川正清
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08378
[Presentation] ヒトiPS細胞由来腸管上皮細胞におけるカルボキシルエステラーゼの機能解析2017
- Author(s)
  壁谷和樹、松村若菜、岩尾岳洋、細川正清、松永民秀
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08378
[Presentation] Species Differences of mouse, cynomolgus monkey ans human carboxylesterase using atorvastatin esters with various steric ans electronic properties2017
- Author(s)
  Sachiko Sakai, Kenta Mizoi, Masato Takahashi, Masami Haba, Yasuhiro Uno, Teruko Imai, Masakiyo Hosokawa
- Organizer
  he 32nd JSSX Annual Meeting, Tokyo,
- Data Source
  KAKENHI-PROJECT-16K08378
[Presentation] Development of Caco-2 cells carrying the human small intestine-type carboxylesterase expression profike as a new tool for ester-containing drug absorption studies2016
- Author(s)
  Yuma Ishizaki, Tomomi Furihata, Ohura Kayoko, Teruko Imai, Masakiyo Hosokawa, Hidetaka Akita, Kan,Chiba
- Organizer
  31st JSSX Annual Meeting, Matsumoto, 2016
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K08378
[Presentation] Investigation of substrate specificity for carboxylesterase using ester derivatives of atorvastatin2016
- Author(s)
  Masato Takahashi, Kenta Mizoi, Masami Haba, Masakiyo Hosokawa
- Organizer
  31st JSSX Annual Meeting, Matsumoto, 2016
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K08378
[Presentation] Characterization and properties of cynomolgus monkey carboxyl esterase (CES) isozymes2012
- Author(s)
  Ishida T, Sudou A, Hatano Y, Uno Y, Imai T, Hosokawa M
- Organizer
  日本薬物動態学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590206
[Presentation] Enzymatic characteristics of monkey and human carboxyl esterase 2 and its age-dependent expression2012
- Author(s)
  Ohura K, Fujihara S, Uno Y, Hosokawa M, Imai T
- Organizer
  日本薬物動態学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590206
[Presentation] Dexamethasone mediate transcriptional regulation of carboxylesterase 1A1 gene in human fetal liver cells
- Author(s)
  Hosokawa M, Hori T, Matsunaga T, Ohmori S.
- Organizer
  19th North American ISSX/29thJSSX Meeting
- Place of Presentation
  San Francisco、U.S.A.
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25293035
[Presentation] Dexamethasone mediate transcriptional regulation of carboxylesterase 1A1 gene in human fetal liver cells
- Author(s)
  Hosokawa Masakiyo, Hori Takeshi. Matsuanga Tamihide, Ohmori Shigeru
- Organizer
  19th North American ISSX Meeting and 29th JSSX Annual Meeting,
- Place of Presentation
  San Francisco, California, USA,
- Year and Date
  2014-10-18 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590206

1. Chiba Kan (40159033)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KOBAYASHI Kaoru (30255864)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. SATOH Tetsuo (60092061)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. IMAI Teruko (70176478)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. FURIHATA Tomomi (80401008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KAZUKI Yasuhiro (90403401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OHMORI Shigeru (70169069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ISHIZAKI Takashi (50158747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKETANE Megumi (10315294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KUBOTA Takahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 松永民秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 須崎友紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 杉山雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

hosokawa masakiyo 細川 正清

HOSOKAWA Masakiyo 細川 正清

Research Projects

Research Products

Co-Researchers

Organ-specific expression of prodrug converting enzyme and construction of metabolic model cell linePrincipal Investigator

Principal Investigator

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Establishment of in vitro and in vivo models for human CES which promote rational development of ester-based prodrugs

Principal Investigator

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Molecular mechanism of the tissue-specific expression of the hydrolases which enzymes related to structure activity relationship of pro-drugsPrincipal Investigator

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Individual differences of the regulation mechanism of the human carboxylesterase genePrincipal Investigator

Principal Investigator

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Identification of hepatic genes regulated in early phase of cholestasis by cDNA microarray analysis in rats

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Species differences in the regulation mechanisms between human and mouse carboxylesterase genesPrincipal Investigator

Principal Investigator

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Ratinal design of drags containing ester bond based on carboxylesterase activity

Principal Investigator

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Gene polymorphism of CYP2C subfamily and inter-individual differences in drug metabolism

Principal Investigator

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Molecular aspect of drug transport and metabolism by brain carboxylesterases in rats and humansPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

ヒト脳血管内皮細胞に局在するエステラーゼを介する薬物透過の分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

Studies on the metabolism and toxicity of drugs using mammalian cells expressed in drug metabolism enzymes

Principal Investigator

Project Period (FY)

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Research Institution

[Book] 9.1.5「異物代謝に影響を及ぼす因子」衛生薬学 第6版（編集永沼章、姫野誠一郎、平塚明）2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 2.2.2.ｃ「カルボキシルエステラーゼ」医療薬物代謝学 第2版（編集 山崎浩史、小澤正吾）2018

Author(s)

Total Pages

hosokawa masakiyo 細川正清

HOSOKAWA Masakiyo 細川正清

[Book] 9.1.5「異物代謝に影響を及ぼす因子」衛生薬学　第6版（編集永沼章、姫野誠一郎、平塚明）2018

[Book] 2.2.2.ｃ「カルボキシルエステラーゼ」医療薬物代謝学　第2版（編集　山崎浩史、小澤正吾）2018

[Book] スタンダード薬学シリーズII第6巻医療薬学IV　薬の生体内運命2016

[Book] 薬学領域の病原微生物学・感染症学・化学療法学　第3版2016

[Book] 薬剤学実験法必携マニュアルII生物薬剤学　第5章薬物代謝実験2014

[Book] 酵素誘導実験　薬剤学実験法必携マニュアルII生物薬剤学（日本薬剤学会編集委員会編）2014

[Book] 9章1-5異物代謝に影響を及ぼす因子　衛生薬学-健康と環境-（永沼章、姫野誠一郎、平塚明編）2014

[Book] 衛生薬学　　第9章　化学物質と毒性2013

[Book] 衛生薬学　第9章化学物質と毒性2013