KITADA Kouichi 北田光一

… Alternative Names

KITADA Mitsukazu 北田光一

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Researcher Number	90110345
Other IDs
Affiliation (based on the past Project Information) *help	2006 – 2011: 千葉大学, 医学部附属病院, 教授 2008: 千葉大学, 医学部・附属病院, 教授 2002 – 2004: 千葉大学, 医学部附属病院, 教授 1997 – 1999: 千葉大学, 医学部, 教授 1998: 千葉大学, 医学部附属病院, 教授 … More 1993 – 1998: 千葉大学, 医学部・附属病院, 教授 1997: 千葉大学, 医学部・付属病院, 教授 1994: 千葉大学, 医学部附属病院, 教授 1992: 千葉大学, 医学部, 教授 1991: 千葉大学, 医学部・附属病院, 副薬剤部長 1988 – 1990: 北海道大学, 薬学部, 助教授 Less
Review Section/Research Field	Principal Investigator 応用薬理学・医療系薬学 / Medical pharmacy / Biological pharmacy / Applied pharmacology Except Principal Investigator 応用薬理学・医療系薬学 / Medical pharmacy / Biological pharmacy / Biological pharmacy / Conservative dentistry / Applied pharmacology / 広領域
Keywords	Principal Investigator CYP3A7 / 遺伝子多型 / 胎児毒性 / 薬物代謝 / drug metabolism / 薬物代謝酵素 / ブスルファン / 小児 / 新生児 / ステロイド代謝 … More / steroid metabolism / CYP / CYP3A4 / ヒト胎児肝 / グルタチオンS-トランスフェラ-ゼ / グルタチオン / 腎障害 / GST / GST-α / GST-π / シクロフォスファミド / 血中濃度 / 血液がん / 造血幹細胞移植 / 薬物動態 / グルタチオンS-転移酵素 / 個別最適化 / 薬物血中濃度モニタリング / 母集団解析 / 医薬品副作用 / 薬物相互作用 / 心臓停止 / DHEA-S / STS / 心機能とステロイド / CYP3A酵素 / スラロイド代謝 / ヒト胎児肝P450 / CYP enzymes / expression in COS-7 cells and TN-5 cells / CYP3A / fetal toxicity / 内因性ステロイド / 尿中6β-OHF / C比 / neonate / endogenous steroids / urinary 6β-OHF / C ratio … More Except Principal Investigator チトクロ-ムPー450 / 肝 / P450 / 漢方薬 / 相互作用 / チトクロムP450 / 薬物代謝 / 遺伝子多型 / 脳 / チトクロームP-450 / 肝ミクロゾーム / サル / CYP2C9 / alternative splicing / 胎児肝 / Pー450IA / ビリルビン尿症 / ラット / ノトプテロール / PXR遺伝子 / CYP3A / 固体差 / SNP / コレステロール / 中性コレステロールエスエラーゼ / スタチン / 中性コレステロールエステラーゼ / マウス / 微量発現 / CYP1A1 / 医薬品代謝 / 発現系 / ヒト肝臓 / オーダーメイド医療 / チェノピリジン / 重篤肝障害 / Idiosyncratic / HLA allele / 簡易遺伝子診断 / 臨床研究 / オーダーメード医療 / 薬物誘発性肝障害 / HLAハプロタイプ / 遺伝子診断 / チエノピリジン / チエノピリじン / HLA ハプロタイプ / 変異原物質活性化 / ヒト / イヌ / シクロゾーム / ミクロゾーム / チトクロームP450 / Monkey / Brain / Liver / Cytochrome P450 / Drug metabolism / Microsomes / ニフェジピン / 歯肉増殖 / プロテオグリカン / 歯肉線維芽細胞 / リボポリサッカライド / サイトカイン / インターロイキン-4 / コンドロイチン硫酸プロテオグリカン / ヘパラン硫酸プロテオグリカン / 歯肉肥大 / 高血圧 / Nifedipine / Gingival hyperplasia / Proteoglycan / Gingival fibroblast / Lipopolysaccharide / Cytokine / 薬物代謝能の個体差 / 脂肪肝 / 遺伝的多型 / スプライシング / 異種細胞発現系 / Interindividual difference in ability of drug metabolism / hepatic steatosis / ハムスタ- / 肝ミクロゾ-ム / 薬物代謝酵素 / 性差 / 精製 / チトクロ-ムP-450 / ハムスター / Cytochrome P-450 / Hamster / Liver microsomes / Drug Metabolizing enzyme / Sex difference / Purification Less

Development of a system, which can pre-avoid anti-platelet agents-induced severe hepatic disfunction that is difficult to predict
- Principal Investigator
  
  ARIYOSHI Noritaka
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Study on the mechanism of lethal and serious drug-induced adverse event in fetusPrincipal Investigator
- Principal Investigator
  
  KITADA Mitsukazu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Chiba University
A role of the neutral cholesterol esterase in the cholesterol metabolism in the brain
- Principal Investigator
  
  ITSUKO Ishii
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
超微量発現酵素が薬物の全身的代謝に果たす役割に関する常識を覆す研究
- Principal Investigator
  
  有吉範高
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
小児におけるがん化学療法の至適個別化に関する研究Principal Investigator
- Principal Investigator
  
  北田光一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
小児における遺伝子情報を考慮した抗癌剤の個別投与設計Principal Investigator
- Principal Investigator
  
  北田光一
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Characterization of CYP2C9-splicing variant isolated from human liver
- Principal Investigator
  
  ARIYOSHI Noritaka
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Chiba University
CYP3A4の誘導的発現倍率を制御する遺伝要因の探索的臨床研究
- Principal Investigator
  
  ARIYOSHI Noritaka
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
Study of medication design considering the drug metabolic activities in neonatal period.Principal Investigator
- Principal Investigator
  
  KITADA Mitsukazu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
医薬品適正使用を指向した診断マーカーとしての薬物代謝酵素の有用性に関する研究Principal Investigator
- Principal Investigator
  
  北田光一
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
Studies on the prediction of fetal toxicity caused by drugsPrincipal Investigator
- Principal Investigator
  
  KITADA Mitsukazu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
Cytological and pharmacological studies on the pathogenesis of nifedipine-associated gingival hyperplasia
- Principal Investigator
  
  NOGUCHI Kazuyuki, 魚島マリコ
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Tokyo Medical and Dental University
薬物間相互作用の予測に関する研究:漢方薬との相互作用を中心として
- Principal Investigator
  
  大森栄
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
最適な薬物投与設計を目指した薬物相互作用の予測に関する研究
- Principal Investigator
  
  大森栄
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
Studies on prediction of fetal toxicity caused by drugs.Principal Investigator
- Principal Investigator
  
  KITADA Mitsukazu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
Studies on the structure and function of cytochrome P450 in monkey brain
- Principal Investigator
  
  OHMORI Shigeru
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
高ビリルビン尿症ラットの肝シトクロムP-450分子種変動機構の解明
- Principal Investigator
  
  大森栄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
胎児性肝チトクロ-ムPー450に関する薬理学的・毒性学的研究
- Principal Investigator
  
  金久保好男
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
ヒト胎児肝に特異的に存在するグルタチオンS-トランスフェラ-ゼに関する研究Principal Investigator
- Principal Investigator
  
  北田光一
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
癌原・変異原物質を活性化するチトクロームP-450の発現と発癌リスクの予測
- Principal Investigator
  
  鎌滝哲也
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
Regulation of Sex-Specific Forms of Cytochrome P-450 : Cytochrome P-450 in Liver Microsomes of Hamsters
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  Hokkaido University

All 2010 2009 2008

All Journal Article Presentation

[Journal Article] Enhanced susceptibility of HLA-mediated ticlopidine-induced idiosyncratic hepatotoxicity by CYP2B6 polymorphism in Japanese.2010
- Author(s)
  Ariyoshi N, Iga Y, Hirata K, Sato Y, Miura G, Ishii I, Nagamori S, Kitada M.
- Journal Title
  
  Drug Metab Pharmacokinet. 25
  
  Pages: 298-306
- NAID
  10027583017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390045
[Journal Article] Six Novel Single Nucleotide Polymorphisms of the Steroid Sulfatase Geneina Japanese Population.2010
- Author(s)
  Matsumoto J, Ariyoshi N, Ishii I, Kitada M.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 25 Pages: 403-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390157
[Journal Article] Enhanced susceptibility of HLA-mediated ticlo-pidine-induced idiosyncratic hepato-toxicity by CYP2B6 polymorphism in Japanese2010
- Author(s)
  Ariyoshi N, Iga Y, Hirata K, Sato Y, Miura G, Ishii I, Nagamori S, Kitada M.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 25(3) Pages: 298-306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390045
[Journal Article] Six Novel Single Nucleotide Polymorphisms of the Steroid Sulfatase Gene in a Japanese Population.2010
- Author(s)
  Matsumoto J, Ariyoshi N, Ishii I, Kitada M
- Journal Title
  
  Drug Metab Pharmacokinet. 25(4)
  
  Pages: 403-407
- NAID
  10027583501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390157
[Journal Article] Growth inhibition and differentiation of cultured smooth muscle cells depend on cellular crossbridges across the tubular lumen of type I collagen matrix honeycombs2009
- Author(s)
  Suzuki T, Ishii I, Kotani A, Masuda M, Hirata K, Ueda M, Ogata T, Sakai T, Ariyoshi N, Kitada M
- Journal Title
  
  Microvasc Res 77(2)
  
  Pages: 143-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590056
[Journal Article] Growth inhibition and differentiation of cultured smooth muscle cells depend on sellular crossbridges across the tubular lumen of type I collagen matrix honeycombs.2009
- Author(s)
  Suzuki T, Ishii I, Kotani A, Masuda M, Hirata K, Ueda M, Ogata T, Sakai T, Ariyoshi N, Kitada M
- Journal Title
  
  Microvasc Res. 77(2)
  
  Pages: 143-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590056
[Journal Article] Effect of pitavastatin on macrophage cholesterol metabolism2008
- Author(s)
  Akisato Y, Ishii I, Kitahara M, Tamaki T, Saito Y, Kitada M
- Journal Title
  
  Yakugaku Zasshi 128(3)
  
  Pages: 357-63
- NAID
  110006646588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590056
[Journal Article] Effect of pitavastatin on macrophage cholesterol metabolism.2008
- Author(s)
  Akisato Y, ishii I, Kitahara M, Tamaki T, Saito Y, Kitada M
- Journal Title
  
  Yakugaku Zasshi 128(3)
  
  Pages: 357-363
- NAID
  110006646588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590056
[Presentation] タウリンクロラミンのコレステロール蓄積抑制作用2009
- Author(s)
  宮崎宏史、石井伊都子、有吉範高、北田光一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19590056

1. ITSUKO Ishii (00202929)

# of Collaborated Projects: 13 results

# of Collaborated Products: 9 results
2. ARIYOSHI Noritaka (00243957)

# of Collaborated Projects: 10 results

# of Collaborated Products: 7 results
3. OHMORI Shigeru (70169069)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
4. OHI Hiroaki (60194065)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. KOMORI Masayuki (40183347)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KAMATAKI Tetsuya (00009177)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. NOGUCHI Kazuyuki (90218298)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 仲佐啓詳 (60260478)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. CHIBA Kan (40159033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YANAGISHITA Masaki (70132793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 金久保好男 (30004873)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 力久忠昭 (70012622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 魚島マリコ (50228425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KITADA Kouichi 北田 光一

KITADA Mitsukazu 北田 光一

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Study on the mechanism of lethal and serious drug-induced adverse event in fetusPrincipal Investigator

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小児におけるがん化学療法の至適個別化に関する研究Principal Investigator

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小児における遺伝子情報を考慮した抗癌剤の個別投与設計Principal Investigator

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Study of medication design considering the drug metabolic activities in neonatal period.Principal Investigator

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医薬品適正使用を指向した診断マーカーとしての薬物代謝酵素の有用性に関する研究Principal Investigator

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Studies on the prediction of fetal toxicity caused by drugsPrincipal Investigator

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KITADA Kouichi 北田光一

KITADA Mitsukazu 北田光一