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NAKAYAMA Koh  中山 恒

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中山 恒  ナカヤマ コウ

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Researcher Number 10451923
Other IDs
Affiliation (Current) 2025: 旭川医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2020 – 2023: 旭川医科大学, 医学部, 教授
2011 – 2019: 東京医科歯科大学, 難治疾患研究所, 准教授
2007 – 2010: Tokyo Medical and Dental University, 難治疾患研究所, 特任講師
2008: 医科歯科大, 難治疾患研究所
Review Section/Research Field
Principal Investigator
General medical chemistry / Biological Sciences / Basic Section 48040:Medical biochemistry-related / Medium-sized Section 50:Oncology and related fields
Except Principal Investigator
Basic Section 54040:Metabolism and endocrinology-related / Digestive surgery
Keywords
Principal Investigator
低酸素応答 / 遺伝子発現 / CREB / シグナル伝達 / プロリン水酸化 / 代謝 / 代謝制御 / 転写因子 / PHD3 / タンパク質 … More / がん / 腫瘍形成 / 染色体構造 / 転写 / HIF / 転写制御 / PRP19 / プロリン水酸化酵素 / タンパク質複合体 / 細胞死 / 生体分子医学 / 質量分析 / 細胞培養 / 免疫沈降 / プロテオーム / 細胞増殖 / ピルビン酸脱水素酵素PDH / がん細胞 / 遺伝子発現制御 / ピルビン酸脱水素酵素 / 腫瘍 / 代謝酵素 / ヒストンメチル化 / 核内遺伝子配置 / クロマチン構造 / PDC / Phd / PDH / 遺伝子 / 蛋白質 / 核内外輸送 / 水酸化 / 慢性期 / 遺伝子配置 / NF-kB / がん転移 / 長期低酸素 / caspase / プロモーター / プロリン水素化酵素 / タンパク質間相互作用 / エネルギー代謝 … More
Except Principal Investigator
乳がん / アンドロゲン / 低酸素 / 抗アンドロゲン薬抵抗性 / スフェロイド / MDA-MB-453 / Enzalutamide / 低酸素環境 / トランスジェニックマウス / 発癌 / 制御性T細胞 / エピゲノム / 癌抑制遺伝子 / トランスレーショナルリサーチ / 分子標的剤 / ゲノム編集 / 免疫チェックポイント / 膵腫瘍 / 幹細胞 / 癌 Less
  • Research Projects

    (12 results)
  • Research Products

    (94 results)
  • Co-Researchers

    (8 People)
  •  Regulation of tumor growth mediated by pyruvate dehydrogenase PDHPrincipal Investigator

    • Principal Investigator
      Nakamaya Koh
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Asahikawa Medical College
  •  慢性低酸素環境に注目した乳がんの抗アンドロゲン薬抵抗性獲得機序の解明

    • Principal Investigator
      今道 力敬
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Fukui Prefectural University
  •  Comprehensive analysis of 3D nuclear gene position involved in malignant transformation of hypoxic cancerPrincipal Investigator

    • Principal Investigator
      Nakayama Koh
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Asahikawa Medical College
      Tokyo Medical and Dental University
  •  水酸化酵素Phdの新規基質の同定を基盤とした低酸素応答システムの解明Principal Investigator

    • Principal Investigator
      中山 恒
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Selective gene expression machinary during prolonged phase of hypoxia(Fostering Joint International Research)Principal Investigator

    • Principal Investigator
      NAKAYAMA Koh
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Selective gene expression machinary during prolonged phase of hypoxiaPrincipal Investigator

    • Principal Investigator
      NAKAYAMA Koh
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Analysis of in vivo niches and therapeutic targets for cancer stem cells based on the visualization mechanism

    • Principal Investigator
      Tanaka Shinji
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Tokyo Medical and Dental University
  •  低酸素応答における転写因子の核輸送制御機構の解明-水酸化酵素PHDの新しい機能-Principal Investigator

    • Principal Investigator
      中山 恒
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Molecular mechanism of transcriptional regulation during chronic hypoxic responsePrincipal Investigator

    • Principal Investigator
      NAKAYAMA Koh
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Characterization of the' oxygen sensor' machinery regulating the hypoxia responsePrincipal Investigator

    • Principal Investigator
      NAKAYAMA Koh
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Characterization of the cellular oxygen sensing machineryPrincipal Investigator

    • Principal Investigator
      NAKAYAMA Koh
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Medical and Dental University
  •  低酸素応答における細胞内酸素センサーの同定と解析Principal Investigator

    • Principal Investigator
      中山 恒
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Medical and Dental University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

  • [Book] 細胞2018

    • Author(s)
      榎本 峻秀、中山 恒
    • Total Pages
      2
    • Publisher
      ニューサイエンス社
    • Data Source
      KAKENHI-PROJECT-15K08260
  • [Book] 細胞2018

    • Author(s)
      榎本 峻秀、中山 恒
    • Total Pages
      2
    • Publisher
      ニューサイエンス社
    • Data Source
      KAKENHI-PUBLICLY-17H05523
  • [Book] 炎症と免疫2016

    • Author(s)
      中山 恒
    • Total Pages
      6
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PUBLICLY-15H01396
  • [Book] 炎症と免疫2016

    • Author(s)
      中山 恒
    • Total Pages
      6
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-15K08260
  • [Book] 実験医学5月号2012

    • Author(s)
      中山 恒・合田 亘人
    • Total Pages
      6
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-24590343
  • [Book] 実験医学5月号2012

    • Author(s)
      中山 恒
    • Total Pages
      6
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-24590343
  • [Book] 低酸素応答におけるエネルギー代謝調節The Lung Perspectives2011

    • Author(s)
      中山恒
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Book] 実験医学増刊号がん幹細胞:「がんにおける低酸素応答シグナル伝達」2011

    • Author(s)
      中山恒
    • Total Pages
      7
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Book] がんにおける低酸素応答シグナル伝達実験医学増刊号がん幹細胞

    • Author(s)
      中山恒
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Journal Article] Large-scale mapping of positional changes of hypoxia-responsive genes upon activation.2022

    • Author(s)
      Nakayama K. 他5名
    • Journal Title

      Mol. Biol. Cell.

      Volume: 33 Issue: 8

    • DOI

      10.1091/mbc.e21-11-0593

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06815, KAKENHI-PROJECT-18KK0233
  • [Journal Article] Prolonged hypoxia decreases nuclear pyruvate dehydrogenase complex and regulates the gene expression.2019

    • Author(s)
      Eguchi K. and Nakayama K.*
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 520 Issue: 1 Pages: 128-135

    • DOI

      10.1016/j.bbrc.2019.09.109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Journal Article] Regulation of Gene Expression under Hypoxic Conditions.2019

    • Author(s)
      Nakayama K.* and Kataoka N.*
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 20 Issue: 13 Pages: 3278-3278

    • DOI

      10.3390/ijms20133278

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Journal Article] SpotLearn: Convolutional Neural Network for Detection of Fluorescence In Situ Hybridization (FISH) Signals in High-Throughput Imaging Approaches.2018

    • Author(s)
      Gudla PR., Nakayama K., Pegoraro G., Misteli T.
    • Journal Title

      Cold Spring Harb Symp Quant Biol.

      Volume: - Pages: 57-70

    • DOI

      10.1101/sqb.2017.82.033761

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KK0298
  • [Journal Article] Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells.2018

    • Author(s)
      Yonashiro R, Eguchi K, Wake M, Takeda N, Nakayama K.
    • Journal Title

      Cancer Research

      Volume: 78 Issue: 7 Pages: 1592-1603

    • DOI

      10.1158/0008-5472.can-17-1751

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05523, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15K08260, KAKENHI-PROJECT-18K07225
  • [Journal Article] CREB is activated by ER stress and modulates the unfolded protein response by regulating the expression of IRE1α and PERK.2016

    • Author(s)
      Kikuchi D., Tanimoto K., and Nakayama K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 469 Issue: 2 Pages: 243-250

    • DOI

      10.1016/j.bbrc.2015.11.113

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08260, KAKENHI-PUBLICLY-15H01396
  • [Journal Article] CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells.2016

    • Author(s)
      Katsuta, E., Tanaka, S., Mogushi, K., Shimada, S., Akiyama, Y., Aihara, A., Matsumura, S., Mitsunori, Y., Ban, D., Ochiai, T., Kudo, A., Fukamachi, H., Tanaka, H., Nakayama, K., Arii, S., Tanabe, M.
    • Journal Title

      Int. J. Oncol.

      Volume: 48 Issue: 2 Pages: 657-669

    • DOI

      10.3892/ijo.2015.3299

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06832, KAKENHI-PROJECT-15K10035, KAKENHI-PROJECT-15K15491, KAKENHI-PROJECT-15K19875, KAKENHI-PROJECT-25253081, KAKENHI-PROJECT-15H04926, KAKENHI-PROJECT-25462082, KAKENHI-PROJECT-16H02670, KAKENHI-PROJECT-26870175, KAKENHI-PROJECT-26462025
  • [Journal Article] Prolyl-hydroxylase PHD3 interacts with pyruvate dehydrogenase (PDH)-E1beta and regulates the cellular PDH activity.2014

    • Author(s)
      Kikuchi D., Minamishima YA., and Nakayama K.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 451 Pages: 288-294

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590343
  • [Journal Article] CREB and NF-κB are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1.2013

    • Author(s)
      Koh Nakayama
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288 Issue: 31 Pages: 22584-22595

    • DOI

      10.1074/jbc.m112.421636

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590343
  • [Journal Article] Human PRP19 interacts with prolyl-hydroxylase PHD3 and inhibits cell death in hypoxia2010

    • Author(s)
      Sato M., Sakota M., and Nakayama K.
    • Journal Title

      Exp. Cell Res.

      Volume: 318 Pages: 2871-2882

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Journal Article] Human PRP19 interacts with prolyl-hydroxylase PHD3 and inhibits cell death in hypoxia.2010

    • Author(s)
      Sato M., Sakota M., Nakayama K.
    • Journal Title

      Exp.Cell Res.

      Volume: 318 Pages: 2871-2882

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Journal Article] Growth and progression of melanoma and non-melanoma skin cancers regulated by ubiquitination2010

    • Author(s)
      Nakayama K
    • Journal Title

      Pigment Cell Melanoma Res.

      Volume: 23 Pages: 338-351

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Journal Article] Growth and progression of melanoma and non-melanoma skin cancers regulated by ubiquitination.2010

    • Author(s)
      Nakayama K.
    • Journal Title

      Pigment Cell Melanoma Res.

      Volume: 23 Pages: 338-351

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Journal Article] The ubiquitin ligase Siah2 and the hypoxia response2009

    • Author(s)
      Koh Nakayama et.al., (他2名)
    • Journal Title

      Molecular Cancer Research (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790223
  • [Journal Article] Cellular signal transduction of the hypoxia response2009

    • Author(s)
      Koh Nakayama
    • Journal Title

      J.Biochem. 146

      Pages: 757-765

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790223
  • [Journal Article] The ubiquitin ligase Siah2 and the hypoxia response.2009

    • Author(s)
      Nakayama K., Qi J., Ronai Z.
    • Journal Title

      Mol. Cancer Res. 7

      Pages: 443-451

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790223
  • [Journal Article] Cellular signal transduction of the hypoxia response.2009

    • Author(s)
      Nakayama K
    • Journal Title

      J. Biochem 146

      Pages: 757-765

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790223
  • [Presentation] 早期と長期の低酸素応答を制御する分子機構2023

    • Author(s)
      中山 恒
    • Organizer
      第96回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06815
  • [Presentation] 長期低酸素下における低酸素応答シグナルと小胞体ストレス応答シグナルの相互作用2023

    • Author(s)
      中山 恒
    • Organizer
      第46回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06815
  • [Presentation] Induction of Nuclear Gene Repositioning in response to Hypoxia -a Large Scale Analysis of Hypoxia-Responsive Genes-2023

    • Author(s)
      Koh Nakayama
    • Organizer
      CellBio23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06815
  • [Presentation] Regulation of gene expression during early and late phase of hypoxic response2023

    • Author(s)
      中山 恒
    • Organizer
      第74回日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-21K06815
  • [Presentation] uppression of tumor spheroid formation by matrix metalloproteinase 19 (MMP19) in pyruvate dehydrogenase-E1b (PDH-E1b) knockdown (KD) cells2023

    • Author(s)
      小林之乃、中山 恒
    • Organizer
      第97回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-21K06815
  • [Presentation] Repositioning of hypoxia-responsive genes in the nucleus under prolonged hypoxic conditions2022

    • Author(s)
      中山 恒
    • Organizer
      第95回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] がんの低酸素応答における早期と長期の遺伝子発現制御機構の解析2022

    • Author(s)
      中山 恒
    • Organizer
      日本薬理学会
    • Data Source
      KAKENHI-PROJECT-21K06815
  • [Presentation] がんの低酸素応答における早期と長期の遺伝子発現制御機構の解析2022

    • Author(s)
      中山 恒
    • Organizer
      日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] 乳がんの腫瘍形成におけるピルビン酸デヒドロゲナーゼPDH-E1b の機能解明2022

    • Author(s)
      小林之乃、中山 恒
    • Organizer
      日本薬理学会 北部会
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] 乳がんの腫瘍形成におけるピルビン酸デヒドロゲナーゼPDH-E1b の機能解明2022

    • Author(s)
      小林之乃、中山 恒
    • Organizer
      日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-21K06815
  • [Presentation] 低酸素環境で誘導される小胞体ストレス応答のタンパク質分解による制御機構2022

    • Author(s)
      谷内秀輔、中山 恒
    • Organizer
      日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06815
  • [Presentation] Regulatory mechanism of gene expression during early and late phase of hypoxic response2022

    • Author(s)
      中山 恒
    • Organizer
      日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] Regulatory mechanism of gene expression during early and late phase of hypoxic response2022

    • Author(s)
      中山 恒
    • Organizer
      日本分子生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06815
  • [Presentation] 低酸素環境で誘導される小胞体ストレス応答のタンパク質分解による制御機構2022

    • Author(s)
      谷内秀輔、中山 恒
    • Organizer
      日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] Formation of aberrant tumor metabolism under hypoxic condition2021

    • Author(s)
      中山 恒
    • Organizer
      第94回日本細菌学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] 低酸素環境に応答した核内遺伝子配置変化の解析2021

    • Author(s)
      中山 恒
    • Organizer
      第72回 日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] クロマチン動態から考える低酸素下の遺伝子発現制御2021

    • Author(s)
      中山 恒
    • Organizer
      がんとハイポキシア研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] Hypoxia induces positional changes of genes in the nucleus2021

    • Author(s)
      中山 恒
    • Organizer
      第44回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] クロマチン動態から考える低酸素下の遺伝子発現制御2021

    • Author(s)
      中山 恒
    • Organizer
      がんとハイポキシア研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06815
  • [Presentation] Novel role of pyruvate dehydrogenase PDH -regulation of histone acetylation and gene expression in breast cancer cells-2021

    • Author(s)
      中山 恒
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] Hypomethylation under chronic hypoxia leads to upregulation of oncogenes in breast cancer2021

    • Author(s)
      アタナヤケ バンダラ、中山 恒
    • Organizer
      第34回北海道薬物作用談話会
    • Data Source
      KAKENHI-PROJECT-21K06815
  • [Presentation] Nuclear pyruvate dehydrogenase complex is downregulated during prolonged hypoxia and regulates the gene expression.2020

    • Author(s)
      Nakayama K.
    • Organizer
      Keystone Symposia: Hypoxia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] Transcriptional and post-transcriptional regulation under hypoxic conditions2020

    • Author(s)
      中山 恒
    • Organizer
      第43回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] Prolonged hypoxic condition downregulates Pyruvate Dehydrogenase PDH-E1βand controls the tumor growth by altering the metabolic status in breast cancer cells.2019

    • Author(s)
      Nakayama K.
    • Organizer
      27th FAOBMB meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] 核に局在するピルビン酸脱水素酵素PDHを介した遺伝子発現制御機構の解析2019

    • Author(s)
      中山 恒
    • Organizer
      第17回 がんとハイポキシア研究会
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] Phd-HIFシステム依存的・非依存的に制御される細胞内エネルギー代謝の分子機構2019

    • Author(s)
      中山 恒
    • Organizer
      第42回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] 分子シャペロンTCPファミリーによるピルビン酸脱水素酵素PDHの活性制御機構の解析2019

    • Author(s)
      中山 恒
    • Organizer
      第92回 日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] ピルビン酸脱水素酵素PDH-E1βは長期的な低酸素環境で減少してがん性代謝を制御する2018

    • Author(s)
      中山 恒
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PUBLICLY-17H05523
  • [Presentation] 長期低酸素環境はピルビン酸脱水素酵素PDH-E1βを減少させ、がん性代謝を制御する2018

    • Author(s)
      中山 恒
    • Organizer
      第16回がんとハイポキシア研究会
    • Data Source
      KAKENHI-PUBLICLY-17H05523
  • [Presentation] Pyruvate dehydrogenase PDH-E1β is downregulated under prolonged hypoxic conditions and regulates tumor growth by altering the metabolic status in cancer cells2018

    • Author(s)
      Koh Nakayama
    • Organizer
      Keystone Symposia Hypoxia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05523
  • [Presentation] ピルビン酸脱水素酵素PDH-E1βは長期的な低酸素環境で減少してがん性代謝を制御する2018

    • Author(s)
      中山 恒
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] 長期低酸素環境はピルビン酸脱水素酵素PDH-E1βを減少させ、がん性代謝を制御する2018

    • Author(s)
      中山 恒
    • Organizer
      第16回がんとハイポキシア研究会
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] Pyruvate dehydrogenase PDH-E1β is downregulated under prolonged hypoxic conditions and regulates tumor growth by altering the metabolic status in cancer cells2018

    • Author(s)
      Koh Nakayama
    • Organizer
      Keystone Symposia Hypoxia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18KK0233
  • [Presentation] 慢性的低酸素環境はピルビン酸脱水素酵素PDHの発現を低下させてがん細胞の解糖系に依存した代謝を誘導する2017

    • Author(s)
      與那城 亮、和氣 正樹、武田 憲彦、中山 恒
    • Organizer
      ConBio2017学会
    • Data Source
      KAKENHI-PUBLICLY-17H05523
  • [Presentation] 慢性的低酸素環境においてピルビン酸脱水素酵素PDHの発現を制御する新たな分子機構の同定とそのがん性代謝確立における役割2017

    • Author(s)
      中山 恒
    • Organizer
      がんとハイポキシア研究会
    • Data Source
      KAKENHI-PUBLICLY-17H05523
  • [Presentation] 慢性的低酸素環境においてピルビン酸脱水素酵素PDHの発現を制御する新たな分子機構の同定とそのがん性代謝確立における役割2017

    • Author(s)
      中山 恒
    • Organizer
      がんとハイポキシア研究会
    • Data Source
      KAKENHI-PROJECT-15K08260
  • [Presentation] HIFプロリン水酸化酵素Phd3が形成するタンパク質複合体を介した細胞内エネルギー代謝機構の解析2017

    • Author(s)
      中山 恒
    • Organizer
      第17回日本蛋白質科学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15KK0298
  • [Presentation] HIFプロリン水酸化酵素Phd3が形成するタンパク質複合体を介した細胞内エネルギー代謝機構の解析2017

    • Author(s)
      中山 恒
    • Organizer
      第17回日本蛋白質科学会年会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05523
  • [Presentation] HIFプロリン水酸化酵素Phd3が形成するタンパク質複合体を介した細胞内エネルギー代謝機構の解析2017

    • Author(s)
      中山 恒
    • Organizer
      第17回日本蛋白質科学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08260
  • [Presentation] 慢性的低酸素環境はピルビン酸脱水素酵素PDHの発現を低下させてがん細胞の解糖系に依存した代謝を誘導する2017

    • Author(s)
      與那城 亮、和氣 正樹、武田 憲彦、中山 恒
    • Organizer
      ConBio2017学会
    • Data Source
      KAKENHI-PROJECT-15K08260
  • [Presentation] 低酸素環境における解糖系に依存したエネルギー代謝を制御する新たな分子機構の解析2016

    • Author(s)
      中山 恒
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-11-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-15KK0298
  • [Presentation] CREB regulates the expression of PERK and IRE1alpha, and controls unfolded protein response under hypoxic conditions.2016

    • Author(s)
      Koh Nakayama
    • Organizer
      Experimental Biology2016 meeting
    • Place of Presentation
      サンディエゴ(米国)
    • Year and Date
      2016-04-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08260
  • [Presentation] CREB regulates the expression of PERK and IRE1alpha and controls unfolded protein response under hypoxic conditions.2016

    • Author(s)
      Koh Nakayama
    • Organizer
      Experimental Biology2016 meeting
    • Place of Presentation
      サンディエゴ(米国)
    • Year and Date
      2016-04-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01396
  • [Presentation] 低酸素環境における解糖系に依存したエネルギー代謝を制御する新たな分子機構の解析2016

    • Author(s)
      中山 恒
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-11-30
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-15H01396
  • [Presentation] 低酸素環境における解糖系に依存したエネルギー代謝を制御する新たな分子機構の解析2016

    • Author(s)
      中山 恒
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-11-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08260
  • [Presentation] がんの悪性化における低酸素応答シグナルと小胞体ストレス応答シグナルの新規クロストーク機構の解析2015

    • Author(s)
      中山 恒
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-15K08260
  • [Presentation] Prolyl-hydroxylase PHD3 interacts with pyruvate dehydrogenase2015

    • Author(s)
      Koh Nakayama
    • Organizer
      Keystone Symposia:hypoxia
    • Place of Presentation
      Dublin (Ireland)
    • Year and Date
      2015-05-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01396
  • [Presentation] がんの悪性化における低酸素応答シグナルと小胞体ストレス応答シグナルの新規クロストーク機構の解析2015

    • Author(s)
      中山 恒
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PUBLICLY-15H01396
  • [Presentation] HIFプロリン水酸化酵素PHD3とピルビン酸脱水素酵素PDHの相互作用を介したエネルギー代謝制御機構2014

    • Author(s)
      中山 恒
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-10-17
    • Data Source
      KAKENHI-PROJECT-24590343
  • [Presentation] HIFプロリン水酸化酵素PHD3はピルビン酸脱水素酵素PDH-E1betaと結合して、細胞内のエネルギー代謝を制御する2014

    • Author(s)
      中山 恒、南嶋 洋司
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-27
    • Data Source
      KAKENHI-PROJECT-24590343
  • [Presentation] Regulation of matrix metalloproteinase MMP1 expression by NF-B pathway during prolonged hypoxic conditions2012

    • Author(s)
      Koh Nakayama
    • Organizer
      Keystone Symposia : Advances in hypoxic
    • Place of Presentation
      Banff Fairmont Springs Conference Center
    • Year and Date
      2012-02-14
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Presentation] Regulation of matrix metalloproteinase MMP1 expression by NF-κB pathway during prolonged hypoxic conditions2012

    • Author(s)
      Koh Nakayama
    • Organizer
      Keystone Symposia : Advances in hypoxic signaling
    • Place of Presentation
      Banff, Canada
    • Year and Date
      2012-02-14
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Presentation] 低酸素環境におけるPre-mRNA processing factor (PRP)19による遺伝子発現制御機構2011

    • Author(s)
      中山恒
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Presentation] Regulation of matrix metalloproteinase MMP1 gene expression under prolo nged hypoxic conditions2011

    • Author(s)
      中山恒
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Presentation] Regulation of matrix metalloproteinase MMP1 gene expression under prolonged hypoxic conditions2011

    • Author(s)
      中山恒
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-15
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Presentation] 低酸素環境におけるPre-mRNA processing factor(PRP) 19による遺伝子発現制御機構2011

    • Author(s)
      中山恒
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2011-09-22
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Presentation] Prolyl-hydroxylase PHD3 promotes the PRP19 intramolecular interaction and alters PRP19 activity during hypoxia response2010

    • Author(s)
      Koh Nakayama, (他2名)
    • Organizer
      Keystone Symposia:Hypoxia
    • Place of Presentation
      Keystone, CO, USA
    • Year and Date
      2010-01-21
    • Data Source
      KAKENHI-PROJECT-20790223
  • [Presentation] Pre-mRNA processing factor(PRP)19はプロリン水酸化酵素PHD3と結合して低酸素下での細胞死を抑制する2010

    • Author(s)
      中山恒
    • Organizer
      BMB2010学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Presentation] Prolyl-hydroxylase PHD3 promotes the PRP19 intramolecular interaction and alters PRP19 activity during hypoxia response2010

    • Author(s)
      中山恒, 他2名
    • Organizer
      Keystone Symposia : Hypoxia
    • Place of Presentation
      Keystone, CO, USA
    • Year and Date
      2010-01-21
    • Data Source
      KAKENHI-PROJECT-20790223
  • [Presentation] Pre-mRNA processing factor(PRP) 19はプロリン水酸化酵素PHD3と結合して低酸素下での細胞死を抑制する2010

    • Author(s)
      中山恒、他二名
    • Organizer
      BMB2010
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-22790274
  • [Presentation] Molecular mechanism of ubiquitin ligase PRP19 activation by prolyl-hydroxylase PHD3 during hypoxia response2009

    • Author(s)
      中山恒, 他2名
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Data Source
      KAKENHI-PROJECT-20790223
  • [Presentation] Molecular mechanism of ubiquitin ligase PRP19 activation by prolyl-hydroxylase PHD3 during hypoxia response2009

    • Author(s)
      中山恒, (他2名)
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-11
    • Data Source
      KAKENHI-PROJECT-20790223
  • [Presentation] HIFプロリン水酸化酵素PHD3によるエネルギー代謝調節機構2008

    • Author(s)
      中山恒
    • Organizer
      BMB2008
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-20790223
  • [Presentation] HIFプロリン水酸化酵素PHD3によるエネルギー代謝調節機構2008

    • Author(s)
      中山恒
    • Organizer
      BMB2008学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-20790223
  • [Presentation] HIFプロリン水酸化酵素PHD3の複合体化による活性制御2007

    • Author(s)
      中山 恒
    • Organizer
      BMB2007
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-14
    • Data Source
      KAKENHI-PROJECT-19890060
  • [Presentation] NF-κB/CREB pathway is activated during chronic hypoxia and induces Matrix Metalloproteinase (MMP)1 expression to promote the invasive ability of cancer cells.

    • Author(s)
      中山 恒
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-24590343
  • [Presentation] 長期低酸素応答におけるNF-κB/CREB経路の活性化はマトリックスメタロプロテアーゼMMP1の発現を誘導してがん細胞の浸潤能を亢進する

    • Author(s)
      中山 恒
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24590343
  • [Presentation] 急性期と慢性期の低酸素応答において活性化される転写因子の機能解析

    • Author(s)
      中山 恒
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24590343
  • 1.  Tanaka Shinji (30253420)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  藍原 有弘 (90451939)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  谷本 幸介 (60611613)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  谷水 直樹 (00333386)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  與那城 亮 (60453809)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  今道 力敬 (00570194)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  Misteli Tom
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  深町 博史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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