NAKAYAMA Koh 中山恒

… Alternative Names

中山恒ナカヤマコウ

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Researcher Number	10451923
Other IDs
Affiliation (Current)	2025: 旭川医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 旭川医科大学, 医学部, 教授 2011 – 2019: 東京医科歯科大学, 難治疾患研究所, 准教授 2007 – 2010: Tokyo Medical and Dental University, 難治疾患研究所, 特任講師 2008: 医科歯科大, 難治疾患研究所
Review Section/Research Field	Principal Investigator General medical chemistry / Biological Sciences / Basic Section 48040:Medical biochemistry-related / Medium-sized Section 50:Oncology and related fields Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Digestive surgery
Keywords	Principal Investigator 低酸素応答 / 遺伝子発現 / CREB / シグナル伝達 / プロリン水酸化 / 代謝 / 代謝制御 / 転写因子 / PHD3 / タンパク質 … More / がん / 腫瘍形成 / 染色体構造 / 転写 / HIF / 転写制御 / PRP19 / プロリン水酸化酵素 / タンパク質複合体 / 細胞死 / 生体分子医学 / 質量分析 / 細胞培養 / 免疫沈降 / プロテオーム / 細胞増殖 / ピルビン酸脱水素酵素PDH / がん細胞 / 遺伝子発現制御 / ピルビン酸脱水素酵素 / 腫瘍 / 代謝酵素 / ヒストンメチル化 / 核内遺伝子配置 / クロマチン構造 / PDC / Phd / PDH / 遺伝子 / 蛋白質 / 核内外輸送 / 水酸化 / 慢性期 / 遺伝子配置 / NF-kB / がん転移 / 長期低酸素 / caspase / プロモーター / プロリン水素化酵素 / タンパク質間相互作用 / エネルギー代謝 … More Except Principal Investigator 乳がん / アンドロゲン / 低酸素 / 抗アンドロゲン薬抵抗性 / スフェロイド / MDA-MB-453 / Enzalutamide / 低酸素環境 / トランスジェニックマウス / 発癌 / 制御性T細胞 / エピゲノム / 癌抑制遺伝子 / トランスレーショナルリサーチ / 分子標的剤 / ゲノム編集 / 免疫チェックポイント / 膵腫瘍 / 幹細胞 / 癌 Less

Regulation of tumor growth mediated by pyruvate dehydrogenase PDHPrincipal Investigator
- Principal Investigator
  
  Nakamaya Koh
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Asahikawa Medical College
慢性低酸素環境に注目した乳がんの抗アンドロゲン薬抵抗性獲得機序の解明
- Principal Investigator
  
  今道力敬
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Fukui Prefectural University
Comprehensive analysis of 3D nuclear gene position involved in malignant transformation of hypoxic cancerPrincipal Investigator
- Principal Investigator
  
  Nakayama Koh
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Asahikawa Medical College
  Tokyo Medical and Dental University
水酸化酵素Phdの新規基質の同定を基盤とした低酸素応答システムの解明Principal Investigator
- Principal Investigator
  
  中山恒
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Selective gene expression machinary during prolonged phase of hypoxia(Fostering Joint International Research)Principal Investigator
- Principal Investigator
  
  NAKAYAMA Koh
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
Selective gene expression machinary during prolonged phase of hypoxiaPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Koh
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
Analysis of in vivo niches and therapeutic targets for cancer stem cells based on the visualization mechanism
- Principal Investigator
  
  Tanaka Shinji
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Tokyo Medical and Dental University
低酸素応答における転写因子の核輸送制御機構の解明－水酸化酵素PHDの新しい機能－Principal Investigator
- Principal Investigator
  
  中山恒
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Molecular mechanism of transcriptional regulation during chronic hypoxic responsePrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Koh
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
Characterization of the' oxygen sensor' machinery regulating the hypoxia responsePrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Koh
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
Characterization of the cellular oxygen sensing machineryPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Koh
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
低酸素応答における細胞内酸素センサーの同定と解析Principal Investigator
- Principal Investigator
  
  中山恒
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University

[Book] 細胞2018
- Author(s)
  榎本　峻秀、中山　恒
- Total Pages
  2
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-15K08260
[Book] 細胞2018
- Author(s)
  榎本　峻秀、中山　恒
- Total Pages
  2
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PUBLICLY-17H05523
[Book] 炎症と免疫2016
- Author(s)
  中山　恒
- Total Pages
  6
- Publisher
  先端医学社
- Data Source
  KAKENHI-PUBLICLY-15H01396
[Book] 炎症と免疫2016
- Author(s)
  中山　恒
- Total Pages
  6
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-15K08260
[Book] 実験医学５月号2012
- Author(s)
  中山　恒・合田　亘人
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24590343
[Book] 実験医学５月号2012
- Author(s)
  中山　恒
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24590343
[Book] 低酸素応答におけるエネルギー代謝調節The Lung Perspectives2011
- Author(s)
  中山恒
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-22790274
[Book] 実験医学増刊号がん幹細胞:「がんにおける低酸素応答シグナル伝達」2011
- Author(s)
  中山恒
- Total Pages
  7
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22790274
[Book] がんにおける低酸素応答シグナル伝達実験医学増刊号がん幹細胞
- Author(s)
  中山恒
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22790274
[Journal Article] Large-scale mapping of positional changes of hypoxia-responsive genes upon activation.2022
- Author(s)
  Nakayama K.　他５名
- Journal Title
  
  Mol. Biol. Cell.
  
  Volume: 33 Issue: 8
- DOI
  10.1091/mbc.e21-11-0593
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06815, KAKENHI-PROJECT-18KK0233
[Journal Article] Prolonged hypoxia decreases nuclear pyruvate dehydrogenase complex and regulates the gene expression.2019
- Author(s)
  Eguchi K. and Nakayama K.*
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 520 Issue: 1 Pages: 128-135
- DOI
  10.1016/j.bbrc.2019.09.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0233
[Journal Article] Regulation of Gene Expression under Hypoxic Conditions.2019
- Author(s)
  Nakayama K.* and Kataoka N.*
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 20 Issue: 13 Pages: 3278-3278
- DOI
  10.3390/ijms20133278
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0233
[Journal Article] SpotLearn: Convolutional Neural Network for Detection of Fluorescence In Situ Hybridization (FISH) Signals in High-Throughput Imaging Approaches.2018
- Author(s)
  Gudla PR., Nakayama K., Pegoraro G., Misteli T.
- Journal Title
  
  Cold Spring Harb Symp Quant Biol.
  
  Volume: - Pages: 57-70
- DOI
  10.1101/sqb.2017.82.033761
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0298
[Journal Article] Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells.2018
- Author(s)
  Yonashiro R, Eguchi K, Wake M, Takeda N, Nakayama K.
- Journal Title
  
  Cancer Research
  
  Volume: 78 Issue: 7 Pages: 1592-1603
- DOI
  10.1158/0008-5472.can-17-1751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05523, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15K08260, KAKENHI-PROJECT-18K07225
[Journal Article] CREB is activated by ER stress and modulates the unfolded protein response by regulating the expression of IRE1α and PERK.2016
- Author(s)
  Kikuchi D., Tanimoto K., and Nakayama K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 469 Issue: 2 Pages: 243-250
- DOI
  10.1016/j.bbrc.2015.11.113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08260, KAKENHI-PUBLICLY-15H01396
[Journal Article] CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells.2016
- Author(s)
  Katsuta, E., Tanaka, S., Mogushi, K., Shimada, S., Akiyama, Y., Aihara, A., Matsumura, S., Mitsunori, Y., Ban, D., Ochiai, T., Kudo, A., Fukamachi, H., Tanaka, H., Nakayama, K., Arii, S., Tanabe, M.
- Journal Title
  
  Int. J. Oncol.
  
  Volume: 48 Issue: 2 Pages: 657-669
- DOI
  10.3892/ijo.2015.3299
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06832, KAKENHI-PROJECT-15K10035, KAKENHI-PROJECT-15K15491, KAKENHI-PROJECT-15K19875, KAKENHI-PROJECT-25253081, KAKENHI-PROJECT-15H04926, KAKENHI-PROJECT-25462082, KAKENHI-PROJECT-16H02670, KAKENHI-PROJECT-26870175, KAKENHI-PROJECT-26462025
[Journal Article] Prolyl-hydroxylase PHD3 interacts with pyruvate dehydrogenase (PDH)-E1beta and regulates the cellular PDH activity.2014
- Author(s)
  Kikuchi D., Minamishima YA., and Nakayama K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 451 Pages: 288-294
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590343
[Journal Article] CREB and NF-κB are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1.2013
- Author(s)
  Koh Nakayama
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 288 Issue: 31 Pages: 22584-22595
- DOI
  10.1074/jbc.m112.421636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590343
[Journal Article] Human PRP19 interacts with prolyl-hydroxylase PHD3 and inhibits cell death in hypoxia2010
- Author(s)
  Sato M., Sakota M., and Nakayama K.
- Journal Title
  
  Exp. Cell Res.
  
  Volume: 318 Pages: 2871-2882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790274
[Journal Article] Human PRP19 interacts with prolyl-hydroxylase PHD3 and inhibits cell death in hypoxia.2010
- Author(s)
  Sato M., Sakota M., Nakayama K.
- Journal Title
  
  Exp.Cell Res.
  
  Volume: 318 Pages: 2871-2882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790274
[Journal Article] Growth and progression of melanoma and non-melanoma skin cancers regulated by ubiquitination2010
- Author(s)
  Nakayama K
- Journal Title
  
  Pigment Cell Melanoma Res.
  
  Volume: 23 Pages: 338-351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790274
[Journal Article] Growth and progression of melanoma and non-melanoma skin cancers regulated by ubiquitination.2010
- Author(s)
  Nakayama K.
- Journal Title
  
  Pigment Cell Melanoma Res.
  
  Volume: 23 Pages: 338-351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790274
[Journal Article] The ubiquitin ligase Siah2 and the hypoxia response2009
- Author(s)
  Koh Nakayama et.al., (他2名)
- Journal Title
  
  Molecular Cancer Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790223
[Journal Article] Cellular signal transduction of the hypoxia response2009
- Author(s)
  Koh Nakayama
- Journal Title
  
  J.Biochem. 146
  
  Pages: 757-765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790223
[Journal Article] The ubiquitin ligase Siah2 and the hypoxia response.2009
- Author(s)
  Nakayama K., Qi J., Ronai Z.
- Journal Title
  
  Mol. Cancer Res. 7
  
  Pages: 443-451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790223
[Journal Article] Cellular signal transduction of the hypoxia response.2009
- Author(s)
  Nakayama K
- Journal Title
  
  J. Biochem 146
  
  Pages: 757-765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790223
[Presentation] 早期と長期の低酸素応答を制御する分子機構2023
- Author(s)
  中山　恒
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06815
[Presentation] 長期低酸素下における低酸素応答シグナルと小胞体ストレス応答シグナルの相互作用2023
- Author(s)
  中山　恒
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06815
[Presentation] Induction of Nuclear Gene Repositioning in response to Hypoxia -a Large Scale Analysis of Hypoxia-Responsive Genes-2023
- Author(s)
  Koh Nakayama
- Organizer
  CellBio23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06815
[Presentation] Regulation of gene expression during early and late phase of hypoxic response2023
- Author(s)
  中山　恒
- Organizer
  第74回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-21K06815
[Presentation] uppression of tumor spheroid formation by matrix metalloproteinase 19 (MMP19) in pyruvate dehydrogenase-E1b (PDH-E1b) knockdown (KD) cells2023
- Author(s)
  小林之乃、中山　恒
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06815
[Presentation] Repositioning of hypoxia-responsive genes in the nucleus under prolonged hypoxic conditions2022
- Author(s)
  中山　恒
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] がんの低酸素応答における早期と長期の遺伝子発現制御機構の解析2022
- Author(s)
  中山　恒
- Organizer
  日本薬理学会
- Data Source
  KAKENHI-PROJECT-21K06815
[Presentation] がんの低酸素応答における早期と長期の遺伝子発現制御機構の解析2022
- Author(s)
  中山　恒
- Organizer
  日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] 乳がんの腫瘍形成におけるピルビン酸デヒドロゲナーゼPDH-E1b の機能解明2022
- Author(s)
  小林之乃、中山　恒
- Organizer
  日本薬理学会　北部会
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] 乳がんの腫瘍形成におけるピルビン酸デヒドロゲナーゼPDH-E1b の機能解明2022
- Author(s)
  小林之乃、中山　恒
- Organizer
  日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-21K06815
[Presentation] 低酸素環境で誘導される小胞体ストレス応答のタンパク質分解による制御機構2022
- Author(s)
  谷内秀輔、中山　恒
- Organizer
  日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06815
[Presentation] Regulatory mechanism of gene expression during early and late phase of hypoxic response2022
- Author(s)
  中山　恒
- Organizer
  日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] Regulatory mechanism of gene expression during early and late phase of hypoxic response2022
- Author(s)
  中山　恒
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06815
[Presentation] 低酸素環境で誘導される小胞体ストレス応答のタンパク質分解による制御機構2022
- Author(s)
  谷内秀輔、中山　恒
- Organizer
  日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] Formation of aberrant tumor metabolism under hypoxic condition2021
- Author(s)
  中山　恒
- Organizer
  第94回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] 低酸素環境に応答した核内遺伝子配置変化の解析2021
- Author(s)
  中山　恒
- Organizer
  第72回　日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] クロマチン動態から考える低酸素下の遺伝子発現制御2021
- Author(s)
  中山　恒
- Organizer
  がんとハイポキシア研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] Hypoxia induces positional changes of genes in the nucleus2021
- Author(s)
  中山　恒
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] クロマチン動態から考える低酸素下の遺伝子発現制御2021
- Author(s)
  中山　恒
- Organizer
  がんとハイポキシア研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06815
[Presentation] Novel role of pyruvate dehydrogenase PDH -regulation of histone acetylation and gene expression in breast cancer cells-2021
- Author(s)
  中山　恒
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] Hypomethylation under chronic hypoxia leads to upregulation of oncogenes in breast cancer2021
- Author(s)
  アタナヤケ　バンダラ、中山　恒
- Organizer
  第34回北海道薬物作用談話会
- Data Source
  KAKENHI-PROJECT-21K06815
[Presentation] Nuclear pyruvate dehydrogenase complex is downregulated during prolonged hypoxia and regulates the gene expression.2020
- Author(s)
  Nakayama K.
- Organizer
  Keystone Symposia: Hypoxia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] Transcriptional and post-transcriptional regulation under hypoxic conditions2020
- Author(s)
  中山　恒
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] Prolonged hypoxic condition downregulates Pyruvate Dehydrogenase PDH-E1βand controls the tumor growth by altering the metabolic status in breast cancer cells.2019
- Author(s)
  Nakayama K.
- Organizer
  27th FAOBMB meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] 核に局在するピルビン酸脱水素酵素PDHを介した遺伝子発現制御機構の解析2019
- Author(s)
  中山　恒
- Organizer
  第１７回　がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] Phd-HIFシステム依存的・非依存的に制御される細胞内エネルギー代謝の分子機構2019
- Author(s)
  中山　恒
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] 分子シャペロンTCPファミリーによるピルビン酸脱水素酵素PDHの活性制御機構の解析2019
- Author(s)
  中山　恒
- Organizer
  第９２回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] ピルビン酸脱水素酵素PDH-E1βは長期的な低酸素環境で減少してがん性代謝を制御する2018
- Author(s)
  中山　恒
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-17H05523
[Presentation] 長期低酸素環境はピルビン酸脱水素酵素PDH-E1βを減少させ、がん性代謝を制御する2018
- Author(s)
  中山　恒
- Organizer
  第１６回がんとハイポキシア研究会
- Data Source
  KAKENHI-PUBLICLY-17H05523
[Presentation] Pyruvate dehydrogenase PDH-E1β is downregulated under prolonged hypoxic conditions and regulates tumor growth by altering the metabolic status in cancer cells2018
- Author(s)
  Koh Nakayama
- Organizer
  Keystone Symposia Hypoxia
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05523
[Presentation] ピルビン酸脱水素酵素PDH-E1βは長期的な低酸素環境で減少してがん性代謝を制御する2018
- Author(s)
  中山　恒
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] 長期低酸素環境はピルビン酸脱水素酵素PDH-E1βを減少させ、がん性代謝を制御する2018
- Author(s)
  中山　恒
- Organizer
  第１６回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] Pyruvate dehydrogenase PDH-E1β is downregulated under prolonged hypoxic conditions and regulates tumor growth by altering the metabolic status in cancer cells2018
- Author(s)
  Koh Nakayama
- Organizer
  Keystone Symposia Hypoxia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0233
[Presentation] 慢性的低酸素環境はピルビン酸脱水素酵素PDHの発現を低下させてがん細胞の解糖系に依存した代謝を誘導する2017
- Author(s)
  與那城　亮、和氣　正樹、武田　憲彦、中山　恒
- Organizer
  ConBio2017学会
- Data Source
  KAKENHI-PUBLICLY-17H05523
[Presentation] 慢性的低酸素環境においてピルビン酸脱水素酵素PDHの発現を制御する新たな分子機構の同定とそのがん性代謝確立における役割2017
- Author(s)
  中山　恒
- Organizer
  がんとハイポキシア研究会
- Data Source
  KAKENHI-PUBLICLY-17H05523
[Presentation] 慢性的低酸素環境においてピルビン酸脱水素酵素PDHの発現を制御する新たな分子機構の同定とそのがん性代謝確立における役割2017
- Author(s)
  中山　恒
- Organizer
  がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-15K08260
[Presentation] HIFプロリン水酸化酵素Phd3が形成するタンパク質複合体を介した細胞内エネルギー代謝機構の解析2017
- Author(s)
  中山　恒
- Organizer
  第17回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-15KK0298
[Presentation] HIFプロリン水酸化酵素Phd3が形成するタンパク質複合体を介した細胞内エネルギー代謝機構の解析2017
- Author(s)
  中山　恒
- Organizer
  第17回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05523
[Presentation] HIFプロリン水酸化酵素Phd3が形成するタンパク質複合体を介した細胞内エネルギー代謝機構の解析2017
- Author(s)
  中山　恒
- Organizer
  第17回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08260
[Presentation] 慢性的低酸素環境はピルビン酸脱水素酵素PDHの発現を低下させてがん細胞の解糖系に依存した代謝を誘導する2017
- Author(s)
  與那城　亮、和氣　正樹、武田　憲彦、中山　恒
- Organizer
  ConBio2017学会
- Data Source
  KAKENHI-PROJECT-15K08260
[Presentation] 低酸素環境における解糖系に依存したエネルギー代謝を制御する新たな分子機構の解析2016
- Author(s)
  中山　恒
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15KK0298
[Presentation] CREB regulates the expression of PERK and IRE1alpha, and controls unfolded protein response under hypoxic conditions.2016
- Author(s)
  Koh Nakayama
- Organizer
  Experimental Biology2016 meeting
- Place of Presentation
  サンディエゴ（米国）
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08260
[Presentation] CREB regulates the expression of PERK and IRE1alpha and controls unfolded protein response under hypoxic conditions.2016
- Author(s)
  Koh Nakayama
- Organizer
  Experimental Biology2016 meeting
- Place of Presentation
  サンディエゴ（米国）
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01396
[Presentation] 低酸素環境における解糖系に依存したエネルギー代謝を制御する新たな分子機構の解析2016
- Author(s)
  中山　恒
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01396
[Presentation] 低酸素環境における解糖系に依存したエネルギー代謝を制御する新たな分子機構の解析2016
- Author(s)
  中山　恒
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15K08260
[Presentation] がんの悪性化における低酸素応答シグナルと小胞体ストレス応答シグナルの新規クロストーク機構の解析2015
- Author(s)
  中山　恒
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K08260
[Presentation] Prolyl-hydroxylase PHD3 interacts with pyruvate dehydrogenase2015
- Author(s)
  Koh Nakayama
- Organizer
  Keystone Symposia:hypoxia
- Place of Presentation
  Dublin (Ireland)
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01396
[Presentation] がんの悪性化における低酸素応答シグナルと小胞体ストレス応答シグナルの新規クロストーク機構の解析2015
- Author(s)
  中山　恒
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PUBLICLY-15H01396
[Presentation] HIFプロリン水酸化酵素PHD3とピルビン酸脱水素酵素PDHの相互作用を介したエネルギー代謝制御機構2014
- Author(s)
  中山　恒
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-24590343
[Presentation] HIFプロリン水酸化酵素PHD3はピルビン酸脱水素酵素PDH-E1betaと結合して、細胞内のエネルギー代謝を制御する2014
- Author(s)
  中山　恒、南嶋　洋司
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-24590343
[Presentation] Regulation of matrix metalloproteinase MMP1 expression by NF-B pathway during prolonged hypoxic conditions2012
- Author(s)
  Koh Nakayama
- Organizer
  Keystone Symposia : Advances in hypoxic
- Place of Presentation
  Banff Fairmont Springs Conference Center
- Year and Date
  2012-02-14
- Data Source
  KAKENHI-PROJECT-22790274
[Presentation] Regulation of matrix metalloproteinase MMP1 expression by NF-κB pathway during prolonged hypoxic conditions2012
- Author(s)
  Koh Nakayama
- Organizer
  Keystone Symposia : Advances in hypoxic signaling
- Place of Presentation
  Banff, Canada
- Year and Date
  2012-02-14
- Data Source
  KAKENHI-PROJECT-22790274
[Presentation] 低酸素環境におけるPre-mRNA processing factor (PRP)19による遺伝子発現制御機構2011
- Author(s)
  中山恒
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22790274
[Presentation] Regulation of matrix metalloproteinase MMP1 gene expression under prolo nged hypoxic conditions2011
- Author(s)
  中山恒
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22790274
[Presentation] Regulation of matrix metalloproteinase MMP1 gene expression under prolonged hypoxic conditions2011
- Author(s)
  中山恒
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22790274
[Presentation] 低酸素環境におけるPre-mRNA processing factor(PRP) 19による遺伝子発現制御機構2011
- Author(s)
  中山恒
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22790274
[Presentation] Prolyl-hydroxylase PHD3 promotes the PRP19 intramolecular interaction and alters PRP19 activity during hypoxia response2010
- Author(s)
  Koh Nakayama, (他2名)
- Organizer
  Keystone Symposia:Hypoxia
- Place of Presentation
  Keystone, CO, USA
- Year and Date
  2010-01-21
- Data Source
  KAKENHI-PROJECT-20790223
[Presentation] Pre-mRNA processing factor(PRP)19はプロリン水酸化酵素PHD3と結合して低酸素下での細胞死を抑制する2010
- Author(s)
  中山恒
- Organizer
  BMB2010学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22790274
[Presentation] Prolyl-hydroxylase PHD3 promotes the PRP19 intramolecular interaction and alters PRP19 activity during hypoxia response2010
- Author(s)
  中山恒, 他2名
- Organizer
  Keystone Symposia : Hypoxia
- Place of Presentation
  Keystone, CO, USA
- Year and Date
  2010-01-21
- Data Source
  KAKENHI-PROJECT-20790223
[Presentation] Pre-mRNA processing factor(PRP) 19はプロリン水酸化酵素PHD3と結合して低酸素下での細胞死を抑制する2010
- Author(s)
  中山恒、他二名
- Organizer
  BMB2010
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22790274
[Presentation] Molecular mechanism of ubiquitin ligase PRP19 activation by prolyl-hydroxylase PHD3 during hypoxia response2009
- Author(s)
  中山恒, 他2名
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20790223
[Presentation] Molecular mechanism of ubiquitin ligase PRP19 activation by prolyl-hydroxylase PHD3 during hypoxia response2009
- Author(s)
  中山恒, (他2名)
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20790223
[Presentation] HIFプロリン水酸化酵素PHD3によるエネルギー代謝調節機構2008
- Author(s)
  中山恒
- Organizer
  BMB2008
- Place of Presentation
  神戸国際会議場
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20790223
[Presentation] HIFプロリン水酸化酵素PHD3によるエネルギー代謝調節機構2008
- Author(s)
  中山恒
- Organizer
  BMB2008学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20790223
[Presentation] HIFプロリン水酸化酵素PHD3の複合体化による活性制御2007
- Author(s)
  中山恒
- Organizer
  BMB2007
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19890060
[Presentation] NF-κB/CREB pathway is activated during chronic hypoxia and induces Matrix Metalloproteinase (MMP)1 expression to promote the invasive ability of cancer cells.
- Author(s)
  中山　恒
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24590343
[Presentation] 長期低酸素応答におけるNF-κB/CREB経路の活性化はマトリックスメタロプロテアーゼMMP1の発現を誘導してがん細胞の浸潤能を亢進する
- Author(s)
  中山　恒
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590343
[Presentation] 急性期と慢性期の低酸素応答において活性化される転写因子の機能解析
- Author(s)
  中山　恒
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590343

1. Tanaka Shinji (30253420)

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2. 藍原有弘 (90451939)

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3. 谷本幸介 (60611613)

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4. 谷水直樹 (00333386)

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5. 與那城亮 (60453809)

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6. 今道力敬 (00570194)

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7. Misteli Tom

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8. 深町博史

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NAKAYAMA Koh 中山 恒

中山 恒 ナカヤマ コウ

Research Projects

Research Products

Co-Researchers

Regulation of tumor growth mediated by pyruvate dehydrogenase PDHPrincipal Investigator

Principal Investigator

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慢性低酸素環境に注目した乳がんの抗アンドロゲン薬抵抗性獲得機序の解明

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Comprehensive analysis of 3D nuclear gene position involved in malignant transformation of hypoxic cancerPrincipal Investigator

Principal Investigator

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水酸化酵素Phdの新規基質の同定を基盤とした低酸素応答システムの解明Principal Investigator

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Selective gene expression machinary during prolonged phase of hypoxia(Fostering Joint International Research)Principal Investigator

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Selective gene expression machinary during prolonged phase of hypoxiaPrincipal Investigator

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Analysis of in vivo niches and therapeutic targets for cancer stem cells based on the visualization mechanism

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低酸素応答における転写因子の核輸送制御機構の解明－水酸化酵素PHDの新しい機能－Principal Investigator

Principal Investigator

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Molecular mechanism of transcriptional regulation during chronic hypoxic responsePrincipal Investigator

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Characterization of the' oxygen sensor' machinery regulating the hypoxia responsePrincipal Investigator

Principal Investigator

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Characterization of the cellular oxygen sensing machineryPrincipal Investigator

Principal Investigator

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低酸素応答における細胞内酸素センサーの同定と解析Principal Investigator

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[Book] 細胞2018

Author(s)

Total Pages

NAKAYAMA Koh 中山恒

中山恒ナカヤマコウ