yokoyama akihiko 横山明彦

… Alternative Names

Yokoyama Akihiko 横山明彦

YOSHIDA Hitoshi 横山明彦

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Researcher Number	10506710
Other IDs	https://orcid.org/0000-0002-5639-8068
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Affiliation (based on the past Project Information) *help	2018 – 2024: 国立研究開発法人国立がん研究センター, 研究所, ユニット長 2017: 国立研究開発法人国立がん研究センター, その他部局等, その他(移行) 2016: 京都大学, 医学研究科, 研究員 2014: 京都大学, 医学研究科, 特定准教授 2014: 京都大学, 大学院医学研究科, 特定准教授 … More 2012 – 2014: 京都大学, 医学(系)研究科(研究院), 准教授 2012: 京都大学, メディカルイノベーションセンター, 特定准教授 2011: 京都大学, 医学研究科, 准教授 2011: 京都大学, 医学研究科, 特定准教授 2010: 国立がん研究センター, 室長 2008 – 2009: 国立がんセンター(研究所及び東病院臨床開発センター), 分子腫瘍学部, 室長 Less
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related / Medium-sized Section 50:Oncology and related fields / Biological Sciences Except Principal Investigator Hematology / Basic Section 52050:Embryonic medicine and pediatrics-related / Tumor biology / Biological Sciences
Keywords	Principal Investigator 転写 / 白血病 / MLL / クロマチン / 分子標的薬 / 自己複製 / エピジェネティクス / 蛋白質 / 内科 / 生体分子 … More / 発現制御 / 癌 / 分子標的療法 / DOT1L / ヒストン修飾 / 遺伝子発現 / がん / MOZ / AF10 / 染色体転座 / Wilms腫瘍 / ENL / 腎腫瘍 / タンパク質相互作用 / タンパク質間相互作用 / AEP / タンパク結合 / HBO1 / 分子標的 / 分子病態 / 転写制御 / 治療法 / がん幹細胞 / MENIN / ニッチ / ゲノム / AF4 … More Except Principal Investigator 白血病 / 幹細胞 / 分子標的薬 / 腎腫瘍 / エピジェネティックス / ウィルムス腫瘍 / 小児がん / がん / 転写 / AF4 / MLL / 発がん / NPMc / NPM / YB-1 / nucleophosmin / acute myeloid leukemia / 血液腫瘍学 / 癌 / 老化 / 発現制御 / 発生・分化 / 発現抑制 / シグナル伝達 / ゲノム / PML / 細胞分化 / GATA / PU.1 / MOZ / 造血幹細胞 / 転写制御 Less

ENL変異型Wilms腫瘍の発症におけるDOT1Lヒストンメチル基転移酵素の役割の解明
- Principal Investigator
  
  小俣洋介
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Cancer Center Japan
Development of novel therapies for ENL-mutated Wilms tumorPrincipal Investigator
- Principal Investigator
  
  横山明彦
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  National Cancer Center Japan
Mechanisms of AF10-rearranged leukemiaPrincipal Investigator
- Principal Investigator
  
  横山明彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Cancer Center Japan
Mechanisms of MLL-rearranged leukemiaPrincipal Investigator
- Principal Investigator
  
  Yokoyama Akihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Cancer Center Japan
Development of novel therapy for MLL-rearranged leukemiaPrincipal Investigator
- Principal Investigator
  
  Yokoyama Akihiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  National Cancer Center Japan
  Kyoto University
AEP複合体による転写サイクルの制御メカニズムPrincipal Investigator
- Principal Investigator
  
  横山明彦
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Mechanisms of niche-independent self-renewal by MLL fusion proteinsPrincipal Investigator
- Principal Investigator
  
  YOKOYAMA Akihiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kyoto University
Mechanism of transcriptional activation and leukemogenesis by AF4
- Principal Investigator
  
  OKUDA HIROSHI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kyoto University
The role of the AEP complex in MLL fusion-dependent leukemogenesisPrincipal Investigator
- Principal Investigator
  
  YOKOYAMA Akihiko
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Kyoto University
Mechanisms underlying epigenome regulation by chromatin modifications during stem cell differentiation
- Principal Investigator
  
  NAKANISHI Makoto
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya City University
Development of the novel AML treatments by targeting leukemia stem cells
- Principal Investigator
  
  KITABAYASHI Issay
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  National Cancer Center Japan
Study for regulatory mechanism of normal and leukemic stem cells through transcription factors
- Principal Investigator
  
  KITABAYASHI Issay
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

[Book] 血液内科第77巻第2号2018
- Author(s)
  横山明彦
- Total Pages
  7
- Publisher
  科学評論社
- ISBN
- Data Source
  KAKENHI-PROJECT-16H05337
[Book] MLL遺伝子を標的とする染色体転座」（血液内科 73 巻第6号）2016
- Author(s)
  横山明彦
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-16H05337
[Book] MLLによる造血器腫瘍の発症機構（造血器腫瘍アトラス改訂第５版)2016
- Author(s)
  横山明彦
- Total Pages
  7
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-16H05337
[Book] 「11q23転座とMLL」（日本臨床 74巻増刊号8　白血病学（上））2016
- Author(s)
  横山明彦
- Total Pages
  6
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-16H05337
[Journal Article] MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain2023
- Author(s)
  Becht Dustin C.、Klein Brianna J.、Kanai Akinori、Jang Suk Min、Cox Khan L.、Zhou Bing-Rui、Phanor Sabrina K.、Zhang Yi、Chen Ruo-Wen、Ebmeier Christopher C.、Lachance Catherine、Galloy Maxime、Fradet-Turcotte Amelie、Bulyk Martha L.、Bai Yawen、Poirier Michael G.、C?t? Jacques、Yokoyama Akihiko、Kutateladze Tatiana G.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1-20
- DOI
  10.1038/s41467-023-36368-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-23K24368
[Journal Article] MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins2023
- Author(s)
  Komata Yosuke、Kanai Akinori、Maeda Takahiro、Inaba Toshiya、Yokoyama Akihiko
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1-17
- DOI
  10.1038/s41467-023-37712-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-20H05699, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-23K24368
[Journal Article] BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state2023
- Author(s)
  Xiao Muran、、、、Yokoyama Akihiko、、、、、Inoue Daichi
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1-22
- DOI
  10.1038/s41467-023-44081-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-21K08385, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-23K24368
[Journal Article] Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumors2023
- Author(s)
  Chen Yu、Yamamoto Tatsuki、Takahashi Yura、Moro Tomoka、Tajima Tomoko、Sakaguchi Yukiko、Sakata Naoaki、Yokoyama Akihiko、Hijioka Susumu、Sada Akane、Tabata Yuko、Ohki Rieko
- Journal Title
  
  Cell Death & Disease
  
  Volume: 14 Issue: 9 Pages: 1-13
- DOI
  10.1038/s41419-023-06123-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19644, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-23K24368
[Journal Article] Cross-talk among MEN1, p53 and Notch regulates the proliferation of pancreatic neuroendocrine tumor cells by modulating INSM1 expression and subcellular localization2022
- Author(s)
  Capodanno Ylenia, Chen Yu, Schrader Joerg, Tomosugi M, Sumi S, Yokoyama A, Ohki Rieko
- Journal Title
  
  Neoplasia
  
  Volume: 23 Issue: 9 Pages: 979-992
- DOI
  10.1016/j.neo.2021.07.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15498, KAKENHI-PROJECT-19H03694
[Journal Article] Chromatin-remodeling factor BAZ1A/ACF1 targets UV damage sites in an MLL1-dependent manner to facilitate nucleotide excision repair2022
- Author(s)
  Koyauchi T, Niida H, Motegi A, Sakai S, Uchida C, Ohhata T, Iijima K, Yokoyama A, Suda T, Kitagawa M.
- Journal Title
  
  Biochim Biophys Acta Mol Cell Res .
  
  Volume: 1869 Issue: 11 Pages: 119332-119332
- DOI
  10.1016/j.bbamcr.2022.119332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07308, KAKENHI-PROJECT-20K07378, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-23K24368
[Journal Article] DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells2022
- Author(s)
  Satoru Shinriki;Mayumi Hirayama;Akiko Nagamachi;Akihiko Yokoyama;Takeshi Kawamura;Akinori Kanai;Hidehiko Kawai;Junichi Iwakiri;Rin Liu;Manabu Maeshiro;Saruul Tungalag;Masayoshi Tasaki;Mitsuharu Ueda;Kazuhito Tomizawa;Naoyuki Kataoka;Takashi Ideue;Yutaka Suzuki;Kiyoshi Asai;Tokio Tani;Toshiya Inaba;Hirotaka Matsui
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 11 Pages: 2605-2620
- DOI
  10.1038/s41375-022-01708-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06174, KAKENHI-PROJECT-21K08395, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22K10195, KAKENHI-PROJECT-22K12375, KAKENHI-PROJECT-22K20997, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-20K12041, KAKENHI-PROJECT-23K24368
[Journal Article] Aberrant <i>EVI1</i> splicing contributes to <i>EVI1</i>-rearranged leukemia2022
- Author(s)
  Tanaka Atsushi、Kunimoto Hiroyoshi et al.
- Journal Title
  
  Blood
  
  Volume: 140 Issue: 8 Pages: 875-888
- DOI
  10.1182/blood.2021015325
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08400, KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03714, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-21J15620, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-23K24368
[Journal Article] RNA-Binding Proteins of KHDRBS and IGF2BP families control the Oncogenic Activity of MLL-AF42022
- Author(s)
  Okuda H, Miyamoto M, Takahashi S, Kawamura T Ichikawa J, Harada I, Tamura T and Yokoyama A.
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 6688-6688
- DOI
  10.1038/s41467-022-34558-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-20K08722, KAKENHI-PROJECT-23K24368, KAKENHI-PROJECT-21H02954
[Journal Article] HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways2021
- Author(s)
  Miyamoto R, Kanai A, Okuda H, Komata Y, Takahashi S, Matsui H, Inaba T, *Yokoyama A.
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.64148
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03694, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21K12239
[Journal Article] Leukemogenesis via aberrant self-renewal by the MLL/AEP-mediated transcriptional activation system2021
- Author(s)
  Akihiko Yokoyama
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 10 Pages: 3935-3944
- DOI
  10.1111/cas.15054
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03694
[Journal Article] ole of the MOZ/MLL-mediated transcriptional activation system for self-renewal in normal hematopoiesis and leukemogenesis2021
- Author(s)
  Akihiko Yokoyama
- Journal Title
  
  The FEBS Journal
  
  Volume: N.A. Issue: 24 Pages: 1-16
- DOI
  10.1111/febs.16180
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03694
[Journal Article] HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis2021
- Author(s)
  akahashi S, Kanai A, Okuda H, Miyamoto R, Komata Y, Kawamura T, Matsui H, Inaba T, Takaori-Kondo A, *Yokoyama A
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.65872
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03694, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21K12239
[Journal Article] Multi-organ failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes2021
- Author(s)
  Nagamachi A, Kanai A, Nakamura M, Okuda H, Yokoyama A, Shinriki S, Matsui H, Inaba T.
- Journal Title
  
  J Clin Invest
  
  Volume: 131 Issue: 4 Pages: 1-16
- DOI
  10.1172/jci140147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10360, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-18K08334, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19H03694, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-21K08395
[Journal Article] Protocol for fractionation-assisted native ChIP (fanChIP) to capture protein-protein/DNA interactions on chromatin2021
- Author(s)
  Miyamoto R, Yokoyama A
- Journal Title
  
  STAR Protocols
  
  Volume: 2 Issue: 2 Pages: 100404-100404
- DOI
  10.1016/j.xpro.2021.100404
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16791, KAKENHI-PROJECT-19H03694
[Journal Article] A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells2021
- Author(s)
  Yamamoto Keita、Goyama Susumu、Asada Shuhei、Fujino Takeshi、Yonezawa Taishi、Sato Naru、Takeda Reina、Tsuchiya Akiho、Fukuyama Tomofusa、Tanaka Yosuke、Yokoyama Akihiko、Toya Hikaru、Kon Ayana、Nannya Yasuhito、Onoguchi-Mizutani Rena、Nakagawa Shinichi、Hirose Tetsuro、Ogawa Seishi、Akimitsu Nobuyoshi、Kitamura Toshio
- Journal Title
  
  Cell Reports
  
  Volume: 36 Issue: 8 Pages: 109576-109576
- DOI
  10.1016/j.celrep.2021.109576
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05377, KAKENHI-PUBLICLY-21H00274, KAKENHI-PLANNED-21H05276, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-17H03604, KAKENHI-PROJECT-19H03685, KAKENHI-PROJECT-19H03694, KAKENHI-PROJECT-19J01570, KAKENHI-PROJECT-20K15988, KAKENHI-PLANNED-21H05274
[Journal Article] The molecular functions of common and atypical MLL fusion protein complexes2020
- Author(s)
  Takahashi S, *Yokoyama A.
- Journal Title
  
  BBA - Gene Regulatory Mechanisms
  
  Volume: 1863(7) Issue: 7 Pages: 194548-194548
- DOI
  10.1016/j.bbagrm.2020.194548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03694
[Journal Article] Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia2020
- Author(s)
  Miyamoto Ryo、Okuda Hiroshi、Kanai Akinori、Takahashi Satoshi、Kawamura Takeshi、Matsui Hirotaka、Kitamura Toshio、Kitabayashi Issay、Inaba Toshiya、Yokoyama Akihiko
- Journal Title
  
  Cell Reports
  
  Volume: 32 Issue: 13 Pages: 108200-108200
- DOI
  10.1016/j.celrep.2020.108200
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-18K08334, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K16791, KAKENHI-PROJECT-19H03694
[Journal Article] Vitamin D receptor controls cell stemness in acute myeloid leukemia and in normal bone marrow2020
- Author(s)
  Paubelle E, Zylbersztejn F, Maciel TT, Carvalho C, Mupo A, Cheok M, Lieben L, Sujobert P, Decroocq J, Yokoyama A, Asnafi V, Macintyre E, Tamburini J, Bardet V, Castaigne S, Preudhomme C, Dombret H, Carmeliet G, Bouscary D, Ginzburg YZ, de The H, Benhamou M, Monteiro RC, Vassiliou GS, Hermine O, Moura IC
- Journal Title
  
  Cell Reports
  
  Volume: 30(3) Issue: 3 Pages: 739-754
- DOI
  10.1016/j.celrep.2019.12.055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03694
[Journal Article] Combined Cohesin-Runx1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes2020
- Author(s)
  Ochi Y, Ogawa Seishi., et al.
- Journal Title
  
  Cancer Discov
  
  Volume: - Issue: 6 Pages: 836-853
- DOI
  10.1158/2159-8290.cd-19-0982
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05909, KAKENHI-PLANNED-15H05912, KAKENHI-ORGANIZER-15H05970, KAKENHI-PLANNED-15H05976, KAKENHI-PUBLICLY-19H04806, KAKENHI-PROJECT-19H03560, KAKENHI-PROJECT-17J05245, KAKENHI-INTERNATIONAL-15K21761, KAKENHI-PROJECT-20K21546, KAKENHI-PLANNED-16H06484, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-19H01053, KAKENHI-PROJECT-18K07224, KAKENHI-PROJECT-18K16084, KAKENHI-PROJECT-19K24694, KAKENHI-PROJECT-19H03694
[Journal Article] Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15R138C knock-in mice.2020
- Author(s)
  Tatsumi G, Kawahara M*, Imai T, Nishishita-Asai A, Nishida A, Inatomi O, Yokoyama A, Kakuta Y, Kito K, Andoh A
- Journal Title
  
  Leukemia
  
  Volume: 34 Issue: 3 Pages: 882-894
- DOI
  10.1038/s41375-019-0583-9
- NAID
  120006768264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08811, KAKENHI-PROJECT-19H03694
[Journal Article] HHEX promotes myeloid transformation in cooperation with mutant ASXL12020
- Author(s)
  Takeda R, Asada S, Park SJ, Yokoyama A, Becker H, Kanai A, Visconte V, Hershberger C, Hayashi Y, Yonezawa T, Tamura M, Fukushima T, Tanaka Y, Fukuyama T, Matsumoto A, Yamasaki S, Nakai K, Yamazaki S, Inaba T, Shibata T, Inoue D, Honda H, Goyama S, Maciejewski J, Kitamura T.
- Journal Title
  
  Blood
  
  Volume: 136(14) Issue: Supplement_1 Pages: 1670-1684
- DOI
  10.1182/blood-2019-126663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03694
[Journal Article] RNA Polymerase II-Dependent Transcription Initiated by Selectivity Factor 1: A Central Mechanism Used by MLL Fusion Proteins in Leukemic Transformation2019
- Author(s)
  Akihiko Yokoyama
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 9 Article 722 Pages: 1-15
- DOI
  10.3389/fgene.2018.00722
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05337
[Journal Article] Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis2018
- Author(s)
  Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T
- Journal Title
  
  Nat Commun
  
  Volume: 9 Issue: 1 Pages: 2733-2733
- DOI
  10.1038/s41467-018-05085-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06578, KAKENHI-PUBLICLY-18H05095, KAKENHI-PROJECT-16H05337, KAKENHI-PROJECT-17H05086, KAKENHI-PROJECT-16H06276
[Journal Article] A novel ASXL1?OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies2018
- Author(s)
  Inoue D, Fujino T, Sheridan P, Zhang YZ, Nagase R, Horikawa S, Li Z, Matsui H, Kanai A, Saika M, Yamaguchi R, Kozuka-Hata H, Kawabata KC, Yokoyama A, Goyama S, Inaba T, Imoto S, Miyano S, Xu M, Yang FC, Oyama M, Kitamura T.
- Journal Title
  
  Leukemia
  
  Volume: 印刷中 Issue: 6 Pages: 1327-1337
- DOI
  10.1038/s41375-018-0083-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05634, KAKENHI-PROJECT-15H04855, KAKENHI-PROJECT-15H04857, KAKENHI-PROJECT-16H05337, KAKENHI-PROJECT-18K18196, KAKENHI-PLANNED-16H06578, KAKENHI-PROJECT-18H02838
[Journal Article] Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.2017
- Author(s)
  Okuda H, Stanojevic B, Kanai A, Kawamura T, Takahashi S, Matsui H, Takaori-Kondo A, Yokoyama A.
- Journal Title
  
  J. Clin. Invest.
  
  Volume: in press Issue: 5 Pages: 1918-1931
- DOI
  10.1172/jci91406
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PROJECT-16H05337, KAKENHI-PUBLICLY-17H05649, KAKENHI-PROJECT-15K09478
[Journal Article] MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.2017
- Author(s)
  Yufei Chen, Konstantinos Anastassiadis, Andrea Kranz, A. Francis Stewart, Kathrin Arndt, Claudia Waskow, Akihiko Yokoyama, Kenneth Jones, Tobias Neff, Yoo Lee, Patricia Ernst
- Journal Title
  
  Cancer Cell
  
  Volume: 31 Issue: 6 Pages: 755-770
- DOI
  10.1016/j.ccell.2017.05.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05337
[Journal Article] Molecular mechanisms of MLL-associated leukemia.2015
- Author(s)
  Yokoyama, A.
- Journal Title
  
  International journal of hematology
  
  Volume: 101 Issue: 4 Pages: 352-361
- DOI
  10.1007/s12185-015-1774-4
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22118003, KAKENHI-PROJECT-23689050, KAKENHI-PUBLICLY-25118511, KAKENHI-PROJECT-25670450
[Journal Article] MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters2014
- Author(s)
  Okuda H, Kawaguchi M, Kanai A, Matsui H, Kawamura T, Inaba T, Kitabayashi I, Yokoyama A
- Journal Title
  
  Nucleic Acid Research
  
  Volume: 未定 Issue: 7 Pages: 1-16
- DOI
  10.1093/nar/gkt1394
- NAID
  120005439160
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22118003, KAKENHI-PROJECT-23689050, KAKENHI-PROJECT-24591397, KAKENHI-PUBLICLY-25118511, KAKENHI-PROJECT-25670450, KAKENHI-PROJECT-25870373
[Journal Article] Cleary ML MLL becomes functional through intra-molecular interaction not by proteolytic processing.2013
- Author(s)
  Yokoyama A, Ficara F, Murphy M, Meisel C, Hatanaka C, Kitabayashi I,
- Journal Title
  
  PLOS ONE
  
  Volume: 8(9) Issue: 9 Pages: e73649-e73649
- DOI
  10.1371/journal.pone.0073649
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22118003, KAKENHI-ORGANIZER-22130001, KAKENHI-PROJECT-23689050, KAKENHI-PUBLICLY-25118511, KAKENHI-PROJECT-25670450
[Journal Article] Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.2011
- Author(s)
  Yokoyama A, Ficara F, Murphy MJ, Meisel C, Naresh A, Kitabayashi I, Cleary ML
- Journal Title
  
  J Cell Sci.
  
  Volume: 124 Pages: 2208-2219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390197
[Journal Article] Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways2011
- Author(s)
  Yokoyama A, et al
- Journal Title
  
  J Cell Sci
  
  Volume: 124 Pages: 2208-2219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390197
[Journal Article] Molecular mechanisms of leukemogenesis in MLL-leukemias2011
- Author(s)
  Yokoyama A.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 52(8) Pages: 679-685
- NAID
  10029615131
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22118003
[Journal Article] Molecular mechanisms of leukemogenesis in MLL-leukemias2011
- Author(s)
  Yokoyama A
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 52(8) Pages: 679-685
- NAID
  10029615131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689050
[Journal Article] A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription.2010
- Author(s)
  Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML.
- Journal Title
  
  Cancer Cell 17
  
  Pages: 198-212
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription.2010
- Author(s)
  Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML
- Journal Title
  
  Cancer Cell
  
  Volume: 17 Pages: 198-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390197
[Journal Article] A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription2010
- Author(s)
  Yokoyama A, et al.
- Journal Title
  
  Cancer Cell 17
  
  Pages: 198-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] Phosphorylation of PML is essential for activation of C/EBPe and PU. 1 to accelerate granulocytic differentiation.2008
- Author(s)
  Tagata Y., Yoshida H, Nguyen LA, Kato H, Ichikawa H, Tashiro F, Kitabayashi I.
- Journal Title
  
  Leukemia 22
  
  Pages: 273-280
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] Roles of the histone acetyltransferase MOZ in normal and malignant hematopoiesis.2008
- Author(s)
  Katsumoto T, Yoshida N, Kitabayashi I
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 1523-7
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] Roles of the histone acetyltransferase MOZ in normal and malignant hematopoiesis.2008
- Author(s)
  T. Katsumoto, H. Yoshida, I. Kitabayashi.
- Journal Title
  
  Cancer Sci. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] Phosphorylation of PML is essential for activation of C/EBPe and PU. 1 to accelerate granulocytic differentiation2008
- Author(s)
  Tagata Y., Yoshida H, Nguyen LA, Kato H, Ichikawa H, Tashiro F, Kitabayashi I.
- Journal Title
  
  Leukemia 22
  
  Pages: 273-280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] Phosphorylation of PML is essential for activation of C/E BPe and PU. 1 to accelerate granulocytic differentiation2008
- Author(s)
  Tagata Y., Yoshida H, Nguyen LA, Kato H, Ichikawa H, Tashiro F, Kitabayashi I.
- Journal Title
  
  Leukemia 22
  
  Pages: 273-280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] Chromatin regulation by AML1 complex.2008
- Author(s)
  Yoshida H, Kitabayashi I.
- Journal Title
  
  Int.J.Hematol. 7
  
  Pages: 19-24
- NAID
  10021254940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] Roles of the histone acetyltransferase MOZ in normal and malignant hematopoiesis2008
- Author(s)
  Katsumoto T, Yoshida N, Kitabayashi I
- Journal Title
  
  Cancer Sci 99
  
  Pages: 1523-1527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] Chromatin regulation by AML1 complex2008
- Author(s)
  Yoshida H, Kitabayashi I.
- Journal Title
  
  Int. J. Hematol. 7
  
  Pages: 19-24
- NAID
  10021254940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] PML-RARA inhibits PML IV enhancement of PU. 1-induced C/EBPe induced-expression in myeloid differentiation.2007
- Author(s)
  Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, Naoe T, Pandolfi PP, Kitabayashi I.
- Journal Title
  
  Mol. Cell. Biol. 27
  
  Pages: 5819-5834
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] Phosphorylation of PML is essential for activation of C/EBPe and PU.1 to accelerate granulocytic differentiation.2007
- Author(s)
  Tagata Y., Yoshida H, Nguyen LA, Kato H, Ichikawa H, Tashiro F, Kitabayashi I.
- Journal Title
  
  Mol.Cell.Biol. 22
  
  Pages: 273-280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] PML-RARA inhibits PML IV enhancement of PU.1-induced C/EBPe induced-expression in myeloid differentiation.2007
- Author(s)
  Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, Naoe T, Pandolfi PP, Kitabayashi I.
- Journal Title
  
  Mol.Cell.Biol. 27
  
  Pages: 5819-5834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1-and p53-mediated transcription.2007
- Author(s)
  Li XL, Arai Y, Harada H, Shima Y, Yoshida H, Rokudai S, Aikawa Y, Kimura A, Kitabayashi I.
- Journal Title
  
  Oncogene 26
  
  Pages: 7231-7239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390268
[Journal Article] Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1-and p53-mediated transcription.2007
- Author(s)
  Li XL, Arai Y, Harada H, Shima Y, Yoshida H, Rokudai S, Aikawa Y, Kimura A, Kitabayashi I.
- Journal Title
  
  Oncogene. 26
  
  Pages: 7231-7239
- Data Source
  KAKENHI-PROJECT-19390268
[Patent] 光学活性な架橋型環状２級アミン誘導体2018
- Inventor(s)
  上岡正児、島田尚明、広瀬亘、坂仁志、横山明彦
- Industrial Property Rights Holder
  大日本住友製薬株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-067187
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16H05337
[Presentation] Mechanisms of aberrant self-renewal of leukemia cells2023
- Author(s)
  Akihiko Yokoyama
- Organizer
  Japan-US Hematology meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0119
[Presentation] Epigenetic factors responsible for the aberrant self-renewal of leukemia cells2023
- Author(s)
  Akihiko Yokoyama
- Organizer
  Gordon Research Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0119
[Presentation] Mechanisms of aberrant self-renewal of leukemia cells2023
- Author(s)
  Akihiko Yokoyama
- Organizer
  Japan-US Hematology meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24368
[Presentation] Epigenetic factors responsible for the aberrant self-renewal of leukemia cells2023
- Author(s)
  Akihiko Yokoyama
- Organizer
  Gordon Research Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24368
[Presentation] Roles of MOZ/ENL complex in AF10-rearranged leukemia2023
- Author(s)
  Akihiko Yokoyama
- Organizer
  85th JSH annual meeting
- Data Source
  KAKENHI-PROJECT-22KK0119
[Presentation] MOZ/ENL complex is a therapeutic target for AF10-rearranged leukemia2023
- Author(s)
  Akihiko Yokoyama
- Organizer
  52nd ISEH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0119
[Presentation] Overactivation of non-methylated CpG-rich promoters in leukemia2023
- Author(s)
  Akihiko Yokoyama
- Organizer
  82nd JCA annual meeting
- Data Source
  KAKENHI-PROJECT-22KK0119
[Presentation] 白血病における遺伝子発現異常と創薬2022
- Author(s)
  横山明彦
- Organizer
  鶴岡がん研究シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0119
[Presentation] Mechanisms of aberrant self-renewal of leukemia cells2022
- Author(s)
  Akihiko Yokoyama
- Organizer
  Japan-US Hematology meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0119
[Presentation] Mechanisms of aberrant self-renewal of leukemia cells2022
- Author(s)
  Akihiko Yokoyama
- Organizer
  Japan-US Hematology meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24368
[Presentation] 白血病における遺伝子発現異常と創薬2022
- Author(s)
  横山明彦
- Organizer
  鶴岡がん研究シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K24368
[Presentation] MLL転座白血病における治療標的2021
- Author(s)
  横山　明彦
- Organizer
  第83回　日本血液学会学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03694
[Presentation] Roles of the ENL/MOZ complex in AF10 fusion-mediated leukemogenesis2021
- Author(s)
  Akihiko Yokoyama
- Organizer
  Tsuruoka Conference 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03694
[Presentation] Mechanisms of aberrant self-renewal by mutated epigenetic factors2021
- Author(s)
  Akihiko Yokoyama
- Organizer
  JSPS Core-to-Core Program Symposium “Hematopoiesis and Leukemia”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03694
[Presentation] 白血病における遺伝子発現異常の根源的なメカニズム2020
- Author(s)
  横山明彦
- Organizer
  鶴岡カンファレンス2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03694
[Presentation] Replication of epigenetic profiles by abnormal transcriptional regulators causes leukemia2019
- Author(s)
  Akihiko Yokoyama
- Organizer
  The 6th Cancer Epigenomics Symposium & Seminar in Hematological Malignancies and Epigenetics
- Invited
- Data Source
  KAKENHI-PROJECT-19H03694
[Presentation] Transcriptional Mechanism that Drives MLL-Rearranged Leukemia2018
- Author(s)
  Akihiko Yokoyama
- Organizer
  第9回日本血液学会国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05337
[Presentation] Molecular mechanisms of leukemia stem cell maintenance by MLL fusion proteins2017
- Author(s)
  横山明彦
- Organizer
  日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05337
[Presentation] 11q23転座白血病の発症機序2016
- Author(s)
  横山明彦
- Organizer
  第５６回臨床化学学会年次学術集会
- Place of Presentation
  熊本県熊本市
- Year and Date
  2016-12-04
- Invited
- Data Source
  KAKENHI-PROJECT-16H05337
[Presentation] Molecular mechanism of MLL-associated leukemia2013
- Author(s)
  横山明彦
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川県、パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PUBLICLY-25118511
[Presentation] Molecular mechanism of MLL-associated leukemia2013
- Author(s)
  横山　明彦
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川県、パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25670450
[Presentation] MLL白血病の分子メカニズム2013
- Author(s)
  横山明彦
- Organizer
  第７回先進血液学レクチャー
- Place of Presentation
  東京都、東京ドームホテル
- Invited
- Data Source
  KAKENHI-PUBLICLY-25118511
[Presentation] Molecular mechanism of MLL fusion-dependent transformation2013
- Author(s)
  横山　明彦
- Organizer
  USA-Japan Science Conference　（日米造血器腫瘍セミナー）
- Place of Presentation
  Makena Beach and Golf Resort, Maui, Hawaii、USA
- Year and Date
  2013-03-24
- Invited
- Data Source
  KAKENHI-PLANNED-22118003
[Presentation] Molecular mechanism of MLL-associated leukemia2013
- Author(s)
  横山明彦
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川県、パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-23689050
[Presentation] MLL白血病の分子メカニズム2013
- Author(s)
  横山明彦
- Organizer
  第７回先進血液学レクチャー
- Place of Presentation
  東京都、東京ドームホテル
- Invited
- Data Source
  KAKENHI-PROJECT-23689050
[Presentation] Molecular mechanism of MLL fusion-dependent transformation2013
- Author(s)
  横山　明彦
- Organizer
  日米造血器腫瘍セミナー
- Place of Presentation
  Makena Beach and Golf Resort, Maui, Hawaii、USA
- Invited
- Data Source
  KAKENHI-PROJECT-23689050
[Presentation] MLL白血病の分子メカニズム2013
- Author(s)
  横山　明彦
- Organizer
  第７回先進血液学レクチャー
- Place of Presentation
  東京都、東京ドームホテル
- Invited
- Data Source
  KAKENHI-PROJECT-25670450
[Presentation] MLL白血病の発症メカニズム2012
- Author(s)
  横山明彦
- Organizer
  平成23年度第3次対がん10か年総合戦略(平成16年~25年度)・文部科学省がん研究分野の特性等を踏まえた支援活動合同公開シンポジウム
- Place of Presentation
  東京都(学術総合センター一橋記念講堂)(招待講演)
- Data Source
  KAKENHI-PROJECT-23689050
[Presentation] MLL白血病の発症メカニズム2012
- Author(s)
  横山明彦
- Organizer
  平成23年度第3次対がん10か年総合戦略(平成16年～25年度)・文部科学省がん研究分野の特性等を踏まえた支援活動合同公開シンポジウム
- Place of Presentation
  学術総合センター一橋記念講堂(東京都)
- Data Source
  KAKENHI-PLANNED-22118003
[Presentation] MLL白血病と転写制御2012
- Author(s)
  横山　明彦
- Organizer
  三重先端癌フォーラム
- Place of Presentation
  三重大学医学部
- Data Source
  KAKENHI-PLANNED-22118003
[Presentation] PU.1-mediated upregulation of CSF1R/cFMSIM-CSFR is critical for MOZ- and MLL-leukemia stem cell potential2008
- Author(s)
  Yukiko Aikawa, Takuo Katsumoto, Naomi Yoshida, Kazutsune Yamagata, Akihiko Yokoyama, Issay Kitabayashi
- Organizer
  日本癌学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19390268
[Presentation] MLL白血病と転写制御
- Author(s)
  横山　明彦
- Organizer
  三重先端がんフォーラム
- Place of Presentation
  三重大学
- Invited
- Data Source
  KAKENHI-PROJECT-23689050
[Presentation] MLL白血病の分子メカニズム
- Author(s)
  横山　明彦
- Organizer
  第７回先進血液学レクチャー
- Place of Presentation
  東京ドームホテル　東京都
- Invited
- Data Source
  KAKENHI-PLANNED-22118003
[Presentation] Mechanisms of aberrant self-renewal caused by MLL fusion oncoproteins
- Author(s)
  Akihiko Yokoyama
- Organizer
  4th Global Cancer Genomics Consortium
- Place of Presentation
  京都
- Year and Date
  2014-11-14 – 2014-11-15
- Invited
- Data Source
  KAKENHI-PROJECT-25670450
[Presentation] Molecular mechanism of MLL-associated leukemia
- Author(s)
  横山　明彦
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜　神奈川県
- Invited
- Data Source
  KAKENHI-PLANNED-22118003
[Presentation] Mechanisms of aberrant self-renewal caused by MLL fusion oncoproteins
- Author(s)
  Akihiko Yokoyama
- Organizer
  4th Global Cancer Genomics Consortium
- Place of Presentation
  京都
- Year and Date
  2014-11-14 – 2014-11-15
- Invited
- Data Source
  KAKENHI-PROJECT-23689050
[Presentation] The molecular mechanisms of MLL fusion-dependent leukemic transformation
- Author(s)
  Akihiko Yokoyama
- Organizer
  5th JSH International Symposium
- Place of Presentation
  浜松
- Year and Date
  2014-05-24 – 2014-05-25
- Invited
- Data Source
  KAKENHI-PUBLICLY-25118511
[Presentation] Mechanisms of aberrant self-renewal caused by MLL fusion oncoproteins
- Author(s)
  Akihiko Yokoyama
- Organizer
  4th Global Cancer Genomics Consortium
- Place of Presentation
  京都
- Year and Date
  2015-11-14 – 2015-11-15
- Invited
- Data Source
  KAKENHI-PUBLICLY-25118511
[Presentation] Reading epigenetic marks and activating transcription by MLL fusion proteins
- Author(s)
  Akihiko Yokoyama
- Organizer
  9th 3R symposium
- Place of Presentation
  御殿場
- Year and Date
  2014-11-17 – 2014-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-23689050
[Presentation] Reading epigenetic marks and activating transcription by MLL fusion proteins
- Author(s)
  Akihiko Yokoyama
- Organizer
  9th 3R symposium
- Place of Presentation
  御殿場
- Year and Date
  2014-11-17 – 2014-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-25670450
[Presentation] The molecular mechanisms of MLL fusion-dependent leukemic transformation
- Author(s)
  Akihiko Yokoyama
- Organizer
  5th JSH International Symposium
- Place of Presentation
  浜松
- Year and Date
  2014-05-24 – 2014-05-25
- Invited
- Data Source
  KAKENHI-PROJECT-25670450
[Presentation] Mechanisms of aberrant self-renewal caused by MLL fusion oncoproteins、
- Author(s)
  横山明彦
- Organizer
  4th Global Cancer Genomics Consortium
- Place of Presentation
  京都市京都大学
- Year and Date
  2014-11-14 – 2014-11-15
- Invited
- Data Source
  KAKENHI-PLANNED-22118003
[Presentation] Reading epigenetic marks and activating transcription by MLL fusion proteins、
- Author(s)
  横山明彦
- Organizer
  9th 3R symposium
- Place of Presentation
  静岡県御殿場市ホテルときのしずか
- Year and Date
  2014-11-17 – 2014-11-21
- Invited
- Data Source
  KAKENHI-PLANNED-22118003
[Presentation] The molecular mechanisms of MLL fusion-dependent leukemic transformation
- Author(s)
  横山明彦
- Organizer
  5th JSH International Symposium
- Place of Presentation
  静岡県浜松市アクトシティ浜松
- Year and Date
  2014-05-24 – 2014-05-25
- Invited
- Data Source
  KAKENHI-PLANNED-22118003
[Presentation] Reading epigenetic marks and activating transcription by MLL fusion proteins
- Author(s)
  Akihiko Yokoyama
- Organizer
  9th 3R symposium
- Place of Presentation
  御殿場
- Year and Date
  2014-11-17 – 2014-11-21
- Invited
- Data Source
  KAKENHI-PUBLICLY-25118511
[Presentation] The molecular mechanisms of MLL fusion-dependent leukemic transformation
- Author(s)
  Akihiko Yokoyama
- Organizer
  5th JSH International Symposium
- Place of Presentation
  浜松
- Year and Date
  2014-05-24 – 2014-05-25
- Invited
- Data Source
  KAKENHI-PROJECT-23689050
[]

1. OKUDA Hiroshi (10629215)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 川村猛 (70306835)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. ROKUDAI Susumu (50469970)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. KITABAYASHI Issay (20261175)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
5. YAMAGATA Kazutsune (70311412)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 小俣洋介 (40968559)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 金井昭教 (60549567)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. WATANABE Toshio (60201208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKANISHI Makoto (40217774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 藤井智明 (10511420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OYAMA Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. NIIDA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. SHINRIKI Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 松井啓隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 秦裕子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 北村俊雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 宮本亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 河原真大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 谷時雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 國本博義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 陳ヨ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 広瀬哲郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

yokoyama akihiko 横山 明彦

Yokoyama Akihiko 横山 明彦

YOSHIDA Hitoshi 横山 明彦

Research Projects

Research Products

Co-Researchers

ENL変異型Wilms腫瘍の発症におけるDOT1Lヒストンメチル基転移酵素の役割の解明

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Development of novel therapies for ENL-mutated Wilms tumorPrincipal Investigator

Principal Investigator

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Mechanisms of AF10-rearranged leukemiaPrincipal Investigator

Principal Investigator

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Mechanisms of MLL-rearranged leukemiaPrincipal Investigator

Principal Investigator

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Development of novel therapy for MLL-rearranged leukemiaPrincipal Investigator

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AEP複合体による転写サイクルの制御メカニズムPrincipal Investigator

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Mechanisms of niche-independent self-renewal by MLL fusion proteinsPrincipal Investigator

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Mechanism of transcriptional activation and leukemogenesis by AF4

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The role of the AEP complex in MLL fusion-dependent leukemogenesisPrincipal Investigator

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Mechanisms underlying epigenome regulation by chromatin modifications during stem cell differentiation

Principal Investigator

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Development of the novel AML treatments by targeting leukemia stem cells

Principal Investigator

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Study for regulatory mechanism of normal and leukemic stem cells through transcription factors

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[Book] 血液内科 第77巻第2号2018

Author(s)

yokoyama akihiko 横山明彦

Yokoyama Akihiko 横山明彦

YOSHIDA Hitoshi 横山明彦

[Book] 血液内科第77巻第2号2018

[Book] MLLによる造血器腫瘍の発症機構（造血器腫瘍アトラス改訂第５版)2016

[Book] 「11q23転座とMLL」（日本臨床 74巻増刊号8　白血病学（上））2016