Sekine Ikuo 関根郁夫

… Alternative Names

Researcher Number	10508310
Affiliation (Current)	2020: 筑波大学, 医学医療系, 教授
Affiliation (based on the past Project Information) *help	2020: 筑波大学, 医学医療系, 教授 2015 – 2017: 筑波大学, 医学医療系, 教授 2014: 千葉県がんセンター(研究所), 呼吸器内科, 部長
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator ペメトレキセド / 薬物耐性 / CARP / AMPK / ANKRD1 / 悪性中皮腫 / 耐性 / 薬剤耐性 / 増殖因子 / インシュリン様増殖因子 … More Except Principal Investigator 上皮間葉移行 / TGF / FGF / EGFR / メトホルミン / ニンテダニブ / ピルフェニドン / pirfenidone / nintedanib / MET / 上記間葉転換 / がん / 化学療法 / PD-1 / metformin / mTOR阻害薬 / 薬剤耐性 / mTOR経路 Less

IPF合併肺癌におけるマクロファージ免疫チェックポイント分子制御機構の解明Principal InvestigatorOngoing
- Principal Investigator
  
  関根郁夫
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Tsukuba
Restoration of chemoresistance by modifying epithelial-to-mesenchymal transition.
- Principal Investigator
  
  Takiguchi Yuichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Chiba University
Development of targeted therapy to overcome drug resistance in malignant mesotheliomaPrincipal Investigator
- Principal Investigator
  
  SEKINE Ikuo
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Tsukuba
  Chiba Cancer Center (Research Institute)

All 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Potential Activity of Amrubicin as a Salvage Therapy for Merkel Cell Carcinoma2017
- Author(s)
  Sakaida, E., Ebata, T., Iwasawa, S., Kurimoto, R., Yonemori, S., Ota, S., Nakatani, Y., Sekine, I. and Takiguchi, Y.
- Journal Title
  
  Internal Medicine
  
  Volume: 56 Issue: 5 Pages: 567-570
- DOI
  10.2169/internalmedicine.56.7675
- NAID
  130005399427
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461182, KAKENHI-PROJECT-17K09647
[Journal Article] Augmented expression of cardiac ankyrin repeat protein is induced by pemetrexed and a possible marker for the pemetrexed resistance in mesothelioma cells2017
- Author(s)
  Qin Yiyang、Sekine Ikuo、Fan Mengmeng、Takiguchi Yuichi、Tada Yuji、Shingyoji Masato、Hanazono Michiko、Yamaguchi Naoto、Tagawa Masatoshi
- Journal Title
  
  Cancer Cell Int
  
  Volume: 17 Pages: 1-11
- DOI
  10.1186/s12935-017-0493-8
- NAID
  120006401860
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09598, KAKENHI-PROJECT-17K09647, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-26461183
[Journal Article] An intrapleural administration of zoledronic acid for inoperable malignant mesothelioma patients: a phase I clinical study protocol.2016
- Author(s)
  Tada, Y., Hiroshima, K., Shimada, H., Shingyoji, M., Suzuki, T., Umezawa, H., Sekine, I., Takiguchi, Y., Tatsumi, K. and Tagawa, M.: An intrapleural administration of zoledronic acid for inoperable malignant mesothelioma patients: a phase I clinical study protocol
- Journal Title
  
  SpringerPlus
  
  Volume: 5 Pages: 195-202
- DOI
  10.1186/s40064-016-1893-2
- NAID
  120005753018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461183
[Journal Article] Safety of a short hydration method for cisplatin administration in comparison with a conventional method―a retrospective study.2016
- Author(s)
  Sakaida, E., Iwasawa, S., Kurimoto, R., Ebata, T., Imai, C., Oku, T., Sekine, I., Tada, Y., Tatsumi, K. and Takiguchi, Y.
- Journal Title
  
  Japanese Journal of Clinical Oncology.
  
  Volume: 46 Pages: 370-377
- DOI
  10.1093/jjco/hyv203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461182
[Journal Article] Combination of a third generation bisphosphonate and replication-competent adenoviruses augments the cytotoxicity on mesothelioma2016
- Author(s)
  Jiang, Y., Zhong, B., Kawamura, K., Morinaga, T., Shingyoji, M., Sekine, I., Tada, Y., Tatsumi, K., Shimada, H., Hiroshima, K. and Tagawa, M.
- Journal Title
  
  BMC Cancer
  
  Volume: 16 Pages: 455-455
- DOI
  10.1186/s12885-016-2483-y
- NAID
  120005829742
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462000, KAKENHI-PROJECT-16K09598, KAKENHI-PROJECT-26461183
[Journal Article] Drug resistance originating from a TGF-beta/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation.2016
- Author(s)
  Kurimoto, R., Iwasawa, S., Ebata, T., Ishiwata, T., Sekine, I., Tada, Y., Tatsumi, K., Koide, S., Iwama, A. and Takiguchi, Y.
- Journal Title
  
  International journal of oncology
  
  Volume: 48 Pages: 1825-1836
- DOI
  10.3892/ijo.2016.3419
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461182
[Journal Article] A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene.2015
- Author(s)
  Tada, Y., Hiroshima, K., Shimada, H., Morishita, N., Shirakawa, T., Matsumoto, K., Shingyoji, M., Sekine, I., Tatsumi, K. and Tagawa, M.
- Journal Title
  
  SpringerPlus
  
  Volume: 4 Pages: 358-358
- DOI
  10.1186/s40064-015-1123-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461183, KAKENHI-PROJECT-15K14473
[Journal Article] Alveolar Hemorrhage Associated with Pemetrexed Administration2015
- Author(s)
  Kurimoto, R., Sekine, I., Iwasawa, S., Sakaida, E., Tada, Y., Tatsumi, K., Takahashi, Y., Nakatani, Y., Imai, C. and Takiguchi, Y.
- Journal Title
  
  Internal Medicine
  
  Volume: 54 Issue: 7 Pages: 833-836
- DOI
  10.2169/internalmedicine.54.3414
- NAID
  130005063209
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461182
[Journal Article] Incidence, risk factors and treatment outcomes of extravasation of cytotoxic agents in an outpatient chemotherapy clinic2014
- Author(s)
  Sakaida, E. Sekine, I. Iwasawa, S. Kurimoto, R. Uehara, T. Ooka, Y. Akanuma, N. Tada, Y. Imai, C. Oku, T. Takiguchi, Y.
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 44 Pages: 168-171
- DOI
  10.1093/jjco/hyt186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461182
[Journal Article] Chronic obstructive pulmonary disease as a risk factor for lung cancer2014
- Author(s)
  Takiguchi, Y. Sekine, I. Iwasawa, S. Kurimoto, R. Tatsumi, K.
- Journal Title
  
  World J Clin Oncol
  
  Volume: 5 Pages: 660-666
- DOI
  10.5306/wjco.v5.i4.660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461182
[Journal Article] Detection of chronic obstructive pulmonary disease in community-based annual lung cancer screening: Chiba COPD lung cancer screening study group.2014
- Author(s)
  Sekine Y, Fujisawa T, Suzuki K, Tsutatani S, Kubota K, Ikegami H, Isobe Y, Nakamura M, Takiguchi, Y, Tatsumi K
- Journal Title
  
  Respirol
  
  Volume: 19 Pages: 98-104
- DOI
  10.1111/resp.12179
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23592075, KAKENHI-PROJECT-26461182, KAKENHI-PROJECT-26462139
[Journal Article] Current Status of Medical Oncology in Japan―Reality Gleaned from a Questionnaire Sent to Designated Cancer Care Hospitals2014
- Author(s)
  Takiguchi, Y. Sekine, I. Iwasawa, S. Kurimoto, R. Sakaida, E. Tamura, K.
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 44 Pages: 632-640
- DOI
  10.1093/jjco/hyu059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461182
[Presentation] 悪性中皮腫におけるペメトレキセド耐性はAMPKの活性化が関与する2017
- Author(s)
  鐘博雅、関根郁夫、滝口裕一、グエン・タオ、盛永敬郎、多田裕司、山口直人、田川雅敏
- Organizer
  第76回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-26461183
[Presentation] Enhanced expression of endogenous p53 contributes to E1B55-defective adenoviruses-induced cell death of mesothelioma deleted in the INK4a/ARF region2016
- Author(s)
  Yuji Tada, Thi Thanh Thao Nguyen, Shuji Kubo, Masato Shingyoji, Ikuo Sekine, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
- Organizer
  Tenth international meeting on replicating oncolytic virus therapeutics
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2016-10-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461183
[Presentation] Combination of Forced Transduction of P53 and an Agent That Blocks MDM2-p53 Interactions Produces Synergistic Cytotoxicity on Mesothelioma Defective of the INK4A/ARF Region2016
- Author(s)
  Masatoshi Tagawa, Takao Morinaga, Zhihan Li, Thao Thi Thanh Nguyen, Boya Zhong, Shuji Kubo, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima
- Organizer
  19th annual meeting of American Society of Gene and Cell Therapy
- Place of Presentation
  Washington DC, USA
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461183
[Presentation] E1B-55kDa-defective adenoviruses produced cytotoxicity in combination with MDM2 inhibitors on INK4A/ARF-defective mesothelioma2016
- Author(s)
  Yuji Tada, Thi Thanh Thao Nguyen, Shuji Kubo, Masato Shingyoji, Ikuo Sekine, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
- Organizer
  2016 ESGCT and ISSCR Congress
- Place of Presentation
  Florence, Italy
- Year and Date
  2016-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461183
[Presentation] 細胞周期促進は増殖性アデノウイルスによるアポトーシスを増強するCell cycle promotion enhances apoptosis induced by replication-competent adenoviruses.2016
- Author(s)
  盛永敬郎, グエンタオ, チョンボウヤア, 久保秀司, 関根郁夫, 多田裕司,
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市神奈川県）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26461183
[Presentation] Alteration of drug sensitivity according to the induction and reversion of epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cell lines harboring an EGFR mutation2016
- Author(s)
  Kurimoto, R., Iwasawa, S., Ebata, T., Ishiwata, T., Sekine, I., Tada, Y., Tatsumi, K., Koide, S., Iwama, A. and Takiguchi, Y.
- Organizer
  2016 Annual Meeting: American Association for Cancer Research
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461182
[Presentation] Combination of nutlin-3a and HSP90 inhibitors produces synergistic cytotoxicity on mesothelioma with the wild-type p53.2016
- Author(s)
  Masatoshi Tagawa, Shinya Okamoto, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Toshio Suzuki, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima
- Organizer
  The 13th international conference of the international mesothelioma interested group
- Place of Presentation
  Birmingham, UK
- Year and Date
  2016-05-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461183
[Presentation] MDM2 and MDM4 inhibitors in combination with adenoviruses up-regulating p53 produce synergistic anti-tumor effects on mesothelioma through augmenting apoptotic processes2016
- Author(s)
  Masatoshi Tagawa, Taka-aki Kozono, Yiyang Qin, Xue Rao Ning, Takao Morinaga, Shuji Kubo, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima
- Organizer
  22th annual meeting of Japan Society of Gene Therapy
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2016-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461183
[Presentation] MDMX阻害剤の悪性中皮腫に対する細胞傷害活性はp53非依存的であるが、MDM2阻害剤とは相乗的な併用効果を示すA MDMX inhibitor produces cytotoxicity in a p53-independent manner but achieves synergistic actions with MDM2 inhibitors2016
- Author(s)
  田川雅敏、盛永敬郎、チョンボウヤア、グエンタオ、久保秀司、関根郁夫、多田裕司、巽浩一郎、島田英昭、廣島健三
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市神奈川県）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26461183
[Presentation] 悪性中皮腫細胞に対してHSP90 阻害剤はAKT とMDMX 活性を阻害し、Nutlin-3a と相乗的な抗腫瘍効果を示す2015
- Author(s)
  李知瀚、岡本慎也、盛永敬郎、江媛媛、久保秀司、関根郁夫、滝口裕一、多田裕司、巽浩一郎、島田英昭、廣島健三、田川雅敏
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26461183
[Presentation] HSP90 inhibitor produced synergistic cytotoxicity with nutlin-3a on mesothelioma by inhibiting AKT and MDMX activities.2015
- Author(s)
  Li, Z., Okamoto, S., Morinaga, T., Jiang, Y., Kubo, S., Sekine, I., Takiguchi, Y., Tada, Y., Tatsumi, K., Shimada, H., Hiroshima, K. and Tagawa, M.
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋コングレスセンター（愛知県・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26461182
[Presentation] Transduced p53 enhances cytotoxic effects achieved with oncolytic adenoviruses on pancreatic carcinoma cells
- Author(s)
  Jiang, Y. Okamoto, S. Li, Z. Kubo, S. Sekine, I. Takiguchi, Y. Tada, Y. Tatsumi, K. Shimada, H. Hiroshima, K. Tagawa, M.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26461182
[Presentation] Combination of nutlin-3a and Hsp90 inhibitors produces p53-dependent synergism on human mesothelioma cells
- Author(s)
  Okamoto, S. Jiang, Y. Li, Z. Kubo, S. Sekine, I. Takiguchi, Y. Tada, Y. Tatsumi, K. Shimada, H. Hiroshima, K. Tagawa, M
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26461182

1. Takiguchi Yuichi (30272321)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 岩澤俊一郎 (00527913)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. 田川雅敏 (20171572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
4. 野口雅之 (00198582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 鈴木絢子 (00770348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 鈴木穣 (40323646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 鈴木敏夫 (70771856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKIGUCHI Yuuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 16 results
9. YAMAGUCHI Noritaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. SEKINE Yasuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 新行内雅斗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 山口直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 島田英昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 松本邦夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sekine Ikuo 関根 郁夫

関根 郁夫 セキネ イクオ

SEKINE Ikuo 関根 郁夫

Research Projects

Research Products

Co-Researchers

IPF合併肺癌におけるマクロファージ免疫チェックポイント分子制御機構の解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Restoration of chemoresistance by modifying epithelial-to-mesenchymal transition.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of targeted therapy to overcome drug resistance in malignant mesotheliomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Potential Activity of Amrubicin as a Salvage Therapy for Merkel Cell Carcinoma2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Augmented expression of cardiac ankyrin repeat protein is induced by pemetrexed and a possible marker for the pemetrexed resistance in mesothelioma cells2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] An intrapleural administration of zoledronic acid for inoperable malignant mesothelioma patients: a phase I clinical study protocol.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Safety of a short hydration method for cisplatin administration in comparison with a conventional method―a retrospective study.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination of a third generation bisphosphonate and replication-competent adenoviruses augments the cytotoxicity on mesothelioma2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Drug resistance originating from a TGF-beta/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alveolar Hemorrhage Associated with Pemetrexed Administration2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Incidence, risk factors and treatment outcomes of extravasation of cytotoxic agents in an outpatient chemotherapy clinic2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chronic obstructive pulmonary disease as a risk factor for lung cancer2014

Author(s)

Sekine Ikuo 関根郁夫

関根郁夫セキネイクオ

SEKINE Ikuo 関根郁夫