Noma Kazuhiro 野間和広

… Alternative Names

NOMA Kazuhiro 野間和広

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Researcher Number	10534761
Affiliation (Current)	2025: 岡山大学, 医療開発領域, 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 岡山大学, 大学病院, 講師 2013 – 2020: 岡山大学, 大学病院, 助教 2012: 岡山大学, 卒後臨床研修センター, 助教 2010: Okayama University, 医療教育統合開発センター, 助教 2009: Okayama University, 大学病院, 医員
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related / Cell biology Except Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery / Basic Section 58060:Clinical nursing-related
Keywords	Principal Investigator 光線免疫療法 / 癌関連線維芽細胞 / 食道癌 / がん微小環境 / 腫瘍免疫 / CAFs / 線維芽細胞 / Photoimmunotherapy / 消化器癌 / Tumor microenvironment … More / 難治性癌 / 標的治療 / HER2 / EGFR / PDXモデル / FAP / immunotherapy / Esophageal cancer / 細胞標的治療 / がん関連線維芽細胞 / interleukin 6 / tumor immunosuppression / TILs / esophageal cancer / 腫瘍免疫抑制 / IL-6 / 腫瘍内浸潤リンパ球 / インターロイキン / 腫瘍内リンパ球 / 放射線療法 / 化学療法 / 近赤外線光 / 治療抵抗性 / CAF / 癌微小環境 / 近赤外線 / EMT / Cadherin switch / E-cadherin / 扁平上皮癌 / Tumor microenvironme / 分子標的治療 / Barrett食道癌 / N-cadherin … More Except Principal Investigator 食道癌 / 癌関連線維芽細胞 / がん微小環境 / 癌微小環境 / 食道がん / 患者会 / 術後患者支援システム / 食道がん患者 / メタバース / 腫瘍融解ウイルス / p53 / 腹膜播種 / 微小環境 / 膵がん / ホウ素中性子捕捉療法 / CAFs / PD-L1 / 治療抵抗癌 / 放射線治療 / 放射線療法 / 化学療法 / 転移 / 遠隔転移 / 腫瘍微小環境 / 癌関連線維芽細胞尾 / 遊走能 / 浸潤能 / リンパ節転移 / 近赤外線光 / 光線免疫療法 / 新規治療法 / 新規治療薬 / がん関連線維芽細胞 Less

Validation of Tumor Immune Remodeling Effects of CAF Targeted Therapy in ICI ResistancePrincipal Investigator
- Principal Investigator
  
  野間和広
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
The investigation of the intraperitoneal tumor microenvironment remodeling effect of p53-armed oncolytic virus on peritoneal metastasis.
- Principal Investigator
  
  菊地覚次
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Development of a Postoperative Patient Support System for Esophageal Cancer Using Metaverse
- Principal Investigator
  
  森恵子
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58060:Clinical nursing-related
- Research Institution
  Okayama University
膵がん微小環境を標的としたホウ素中性子捕捉療法の開発
- Principal Investigator
  
  寺石文則
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Exploratory study on the relationship between CAFs and the PD1/PD-L1
- Principal Investigator
  
  Tanabe Shunsuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Preclinical study of photoimmunotherapy for tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Noma Kazuhiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Negative spiral mechanism of cancer associated microenvironment i
- Principal Investigator
  
  Shirakawa Yasuhiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Exploring a mechanism of tumor immunosuppresion induced by cancer-associated fibroblatsPrincipal Investigator
- Principal Investigator
  
  Noma Kazuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Inspection about the influence of circulating tumor microenvironment for metastasis
- Principal Investigator
  
  Shirakawa YAsuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Novel targeting therapy to cancer-associated fibroblasts for treatment-resistant carcinomasPrincipal Investigator
- Principal Investigator
  
  Noma Kazuhiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Therapeutic potential of circulating tumor microenvironment based on metastatic mechanism
- Principal Investigator
  
  Shirakawa Yasuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Development of novel cancer therapy of targeting cancer-associated fibroblastsPrincipal Investigator
- Principal Investigator
  
  NOMA Kazuhiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Essential role of Cadherin family in esophageal cancer and Potential for a novel molecule of targeted therapyPrincipal Investigator
- Principal Investigator
  
  NOMA Kazuhiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Cell biology
- Research Institution
  Okayama University

All 2022 2021 2020 2019 2018 2017 2015 2014 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] Cancer-associated fibroblasts (CAFs) promote the lymph node metastasis of esophageal squamous cell carcinoma.2019
- Author(s)
  Kashima H, Noma K, Ohara T, Kato T, Katsura Y, Komoto S, Sato H, Katsube R, Ninomiya T, Tazawa H, Shirakawa Y, Fujiwara T.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 144 Issue: 4 Pages: 828-840
- DOI
  10.1002/ijc.31953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05416, KAKENHI-PROJECT-16K10500
[Journal Article] Cancer-Associated Fibroblasts Affect Intratumoral CD8+ and FoxP3+ T Cells Via IL6 in the Tumor Microenvironment.2018
- Author(s)
  Kato T, Noma K, Ohara T, Kashima H, Katsura Y, Sato H, Komoto S, Katsube R, Ninomiya T, Tazawa H, Shirakawa Y, Fujiwara T.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 24(19) Pages: 4820-4833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10499
[Journal Article] 宿主正常細胞である癌関連線維芽細胞を標的とした新たな食道癌治療法の開発2015
- Author(s)
  野間和広, 賀島　肇, 二宮卓之, 勝部亮一, 渡邉伸一郎, 大原利章, 田澤　大, 香川俊輔, 白川靖博, 藤原俊義
- Journal Title
  
  癌と化学療法
  
  Volume: 42 Pages: 1228-1230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462020
[Journal Article] Therapeutic Potential of Targeting Cancer-Associated Fibroblasts in Esophageal Cancer2015
- Author(s)
  Noma K, Kashima H, Ninomiya T, Katsube R, Watanabe S, Ohara T, Tazawa H, Kagawa S, Shirakawa Y, Fujiwara T.
- Journal Title
  
  癌と化学療法
  
  Volume: 42 Pages: 1228-30
- Data Source
  KAKENHI-PROJECT-26861077
[Presentation] 癌細胞と癌関連線維芽細胞は互いに PD-L1 を増強させ予後に影響する2022
- Author(s)
  河﨑健人、小林照貴、野間和広ほか
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K09009
[Presentation] 腫瘍免疫の改善に関わる、FAP を標的とした光免疫療法の可能性2022
- Author(s)
  赤井正明、小林照貴、野間和広ほか
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K09009
[Presentation] 癌関連線維芽細胞は免疫チェックポイント分子を介し癌免疫抑制状態へ誘導する2022
- Author(s)
  河﨑健人、小林照貴、野間和広ほか
- Organizer
  第43回癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-20K09009
[Presentation] Drug repositioning による新規がん治療の開発に向けて -がん関連線維芽細胞由来 IL-6 の作用と制御2021
- Author(s)
  國友知義、小林照貴、野間和広ほか
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K09009
[Presentation] 癌関連線維芽細胞がPD-1/PD-L1を制御し予後を不良にする2021
- Author(s)
  河﨑健人、小林照貴、野間和広ほか
- Organizer
  第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議
- Data Source
  KAKENHI-PROJECT-20K09009
[Presentation] 癌関連線維芽細胞による免疫抑制環境での免疫チェックポイント阻害薬の有効性の探求2021
- Author(s)
  河﨑健人、小林照貴、野間和広ほか
- Organizer
  第42回癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-20K09009
[Presentation] Development of novel photoimmunotherapy targeting cancer associated fibroblasts2020
- Author(s)
  小林照貴、野間和広ほか
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-20K09009
[Presentation] A novel photoimmunotherapy for cancer-associated-fibroblasts targeting fibroblast activation protein-α ~Sunrise of targeting tumor microenvironment therapy~2020
- Author(s)
  小林照貴、野間和広ほか
- Organizer
  日本外科学会
- Data Source
  KAKENHI-PROJECT-20K09009
[Presentation] 癌細胞および癌関連線維芽細胞を標的とした光免疫療法の新たな開発2020
- Author(s)
  小林照貴、野間和広ほか
- Organizer
  日本消化器癌発生学会
- Data Source
  KAKENHI-PROJECT-20K09009
[Presentation] 癌細胞および癌関連線維芽細胞を標的とした光免疫療法2020
- Author(s)
  小林照貴、野間和広ほか
- Organizer
  日本癌局所療法研究会
- Data Source
  KAKENHI-PROJECT-20K09009
[Presentation] 癌関連線維芽細胞が引き起こす腫瘍免疫抑制の解明 ―腫瘍浸潤リンパ球とIL-6と代謝の観点から―2018
- Author(s)
  加藤卓也、野間和広　他
- Organizer
  第22回日本がん免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10499
[Presentation] Cancer-associated fibroblasts regulate intratumoral CD8+/FoxP3+ T cells via interleukin 6 in the tumor immune microenvironment.2018
- Author(s)
  Takuka Kato, Kazuhiro Noma, et al.
- Organizer
  The 109th American Association for Cancer Research Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10499
[Presentation] Cancer-associated fibroblasts affect the intra-tumoral infiltration of CD8+ and FoxP3+ T cells via IL-6.2018
- Author(s)
  Takuka Kato, Kazuhiro Noma, et al.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10499
[Presentation] 癌関連線維芽細胞は腫瘍浸潤リンパ球を制御することにより食道癌の予後に寄与する2018
- Author(s)
  加藤卓也、野間和広　他
- Organizer
  第72回日本食道学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10499
[Presentation] 癌関連線維芽細胞は食道癌のリンパ節転移を促進するか　～臨床検体の解析と同所移植モデルを用いた検証～2017
- Author(s)
  賀島　肇，野間　和広，佐藤　浩明，桂　佑貴，加藤　卓也，大原　利章，田澤　大，白川　靖博，藤原　俊義
- Organizer
  第 26 回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-16K10500
[Presentation] 癌関連線維芽細胞は腫瘍浸潤リンパ球を制御することにより腫瘍免疫抑制を調整する2017
- Author(s)
  加藤卓也，野間和広、藤原俊義ほか
- Organizer
  第38回日本癌免疫外科学会
- Data Source
  KAKENHI-PROJECT-16K10499
[Presentation] 癌関連線維芽細胞(CAFs)により放出されるIL-6が腫瘍免疫抑制を引き起こす2017
- Author(s)
  加藤卓也，野間和広、藤原俊義ほか
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10499
[Presentation] 癌関連線維芽細胞による腫瘍免疫抑制と腫瘍浸潤リンパ球制御の同定2017
- Author(s)
  加藤卓也，野間和広、藤原俊義ほか
- Organizer
  第30回日本バイオセラピィ学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10499
[Presentation] Cancer associated fibroblasts promote tumor metastasis coexisting with cancer cells in blood circulation2017
- Author(s)
  Kashima H, Noma K, Sato H, Katsura Y, Kato T, Ohara T, Tazawa H, Shirakawa Y, Fujiwara T
- Organizer
  AACR annual meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10500
[Presentation] 癌関連線維芽細胞はIL-6を介しTILsを制御し腫瘍免疫を抑制する2017
- Author(s)
  加藤卓也，野間和広、藤原俊義ほか
- Organizer
  第26回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10499
[Presentation] Cancer-associated fibroblasts (CAFs) contribute to tumor immunosuppression by regulating tumor-infiltrating lymphocytes2017
- Author(s)
  Takuya Kato, Kazuhiro Noma, Toshiyoshi Fujiwara, et al.
- Organizer
  American Association of Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10499
[Presentation] 食道癌におけるFAP(fibroblast activation protein)陽性癌関連線維芽細胞の発現と癌転移の関係2015
- Author(s)
  賀島肇，野間和広，加藤卓也，勝部亮一，二宮卓之，大原利章，田澤大，白川靖博，香川俊輔，藤原俊義
- Organizer
  第26回消化器癌発生学会
- Place of Presentation
  鳥取県　米子市
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25462020
[Presentation] 宿主正常細胞である癌線維芽細胞を標的とした新たな食道癌治療法の開発2015
- Author(s)
  野間和広
- Organizer
  癌免疫外科研究会
- Place of Presentation
  鹿児島県、日本
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-26861077
[Presentation] Potential of targeting cancer-associated fibroblasts (CAFs) in cancer therapy2014
- Author(s)
  Kazuhiro Noma
- Organizer
  日本外科学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-24791423
[Presentation] Potential of targeting cancer-associated fibroblasts (CAFs) in cancer therapy2014
- Author(s)
  野間和広
- Organizer
  日本外科学会
- Place of Presentation
  京都
- Year and Date
  2014-04-03
- Data Source
  KAKENHI-PROJECT-24791423
[Presentation] Novel photoimmunotherapy (PIT) targeting cancer-associated fibroblast (CAFs) for esophageal cancer2013
- Author(s)
  渡邉伸一郎( 野間和広, 他)
- Organizer
  AACR
- Place of Presentation
  ワシントンDC
- Year and Date
  2013-04-10
- Data Source
  KAKENHI-PROJECT-24791423
[Presentation] Cancer-associated fibroblasts contribute to progression of esophageal cancer2012
- Author(s)
  渡邉伸一郎( 野間和広, 他)
- Organizer
  日本癌学会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-24791423
[Presentation] Analysis of expression patterns of cadherins in esophageal squamous cell carcinomas and Barrett's adenocarcinomas, and a therapeutic potential of cadherins as new target molecule.2011
- Author(s)
  西谷正史、野間和広、藤原俊義, ほか
- Organizer
  American Association of Cancer Research (AACR)
- Place of Presentation
  Washington D.C., USA
- Year and Date
  2011-04-19
- Data Source
  KAKENHI-PROJECT-21870026
[Presentation] Iron deficiency suppressed EMT through down-regulation of N-cadherin in esophageal cancer.2011
- Author(s)
  西谷正史、野間和広、藤原俊義, ほか
- Organizer
  American Association of Cancer Research (AACR)
- Place of Presentation
  Orlando, FL, USA
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-21870026
[Presentation] Iron deficiency suppressed EMT through down-regulation of N-cadherin in esophageal cancer.2011
- Author(s)
  Seishi Nishitani, Kazuhiro Noma, Toshiyoshi Fujiwara, et al.
- Organizer
  AACR
- Data Source
  KAKENHI-PROJECT-21870026
[Presentation] Analysis of expression patterns of cadherins in esophageal squamous cell carcinoma and Barrett's adenocarcinoma and a therapeutic potential of cadherins as new target molecule.2010
- Author(s)
  Seishi Nishitani, Kazuhiro Noma, Toshiyoshi Fujiwara, et al.
- Organizer
  AACR
- Data Source
  KAKENHI-PROJECT-21870026

1. Shirakawa Yasuhiro (60379774)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
2. 賀島肇 (80965187)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. FUJIWARA Toshiyoshi (00304303)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. OHARA Toshiaki (40623533)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. Tanabe Shunsuke (20534770)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 前田直見 (10751117)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 菊地覚次 (40736584)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. TAZAWA Hiroshi (90415513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 寺石文則 (40432661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 道上宏之 (20572499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 橋本将志 (10867477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 冨樫庸介 (80758326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 佐藤伸 (90512004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 森恵子 (70325091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 本家淳子 (20824981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 山下範之 (60901874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 藤井宏子 (80403781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 北別府孝輔 (80975681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 片山はるみ (90412345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 末田朋美 (90553983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KATSUBE Ryoichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. KATO takuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results

Noma Kazuhiro 野間 和広

NOMA Kazuhiro 野間 和広

Research Projects

Research Products

Co-Researchers

Validation of Tumor Immune Remodeling Effects of CAF Targeted Therapy in ICI ResistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The investigation of the intraperitoneal tumor microenvironment remodeling effect of p53-armed oncolytic virus on peritoneal metastasis.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a Postoperative Patient Support System for Esophageal Cancer Using Metaverse

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵がん微小環境を標的としたホウ素中性子捕捉療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploratory study on the relationship between CAFs and the PD1/PD-L1

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Preclinical study of photoimmunotherapy for tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Negative spiral mechanism of cancer associated microenvironment i

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring a mechanism of tumor immunosuppresion induced by cancer-associated fibroblatsPrincipal Investigator

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Inspection about the influence of circulating tumor microenvironment for metastasis

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Novel targeting therapy to cancer-associated fibroblasts for treatment-resistant carcinomasPrincipal Investigator

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Therapeutic potential of circulating tumor microenvironment based on metastatic mechanism

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Development of novel cancer therapy of targeting cancer-associated fibroblastsPrincipal Investigator

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Essential role of Cadherin family in esophageal cancer and Potential for a novel molecule of targeted therapyPrincipal Investigator

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Noma Kazuhiro 野間和広

NOMA Kazuhiro 野間和広