SANEYOSHI HISAO 實吉尚郎

… Alternative Names

實吉尚郎サネヨシヒサオ

HISAO Saneyoshi 實吉尚郎

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Researcher Number	10564784
Other IDs
Affiliation (Current)	2025: 宮崎大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 宮崎大学, 医学部, 准教授 2022 – 2023: 宮崎大学, 医学部, 准教授 2019 – 2020: 滋賀医科大学, 医学部, 助教 2015 – 2018: 神奈川大学, 工学部, 助教 2013 – 2015: 神奈川大学, 工学部, 助手 2012: 独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Chemical biology / Biomolecular chemistry / Chemical biology Except Principal Investigator Inorganic chemistry / Functional materials/Devices
Keywords	Principal Investigator 細胞内化学反応 / 合成核酸 / 核酸合成 / RNA / マウス / 化学療法 / 細胞死 / テロメア / 抗がん / がん … More / 生体内化学反応 / 細胞内デリバリー / 細胞内環境 / 細胞内導入法 / 核酸合成化学 / グルタチオン / 核酸医薬 / 細胞内導入 / 発蛍光色素 / 徐放性 / プロドラッグ / 活性化 / 細胞膜透過性 / 保護基 / 酸化的開裂 / ポスト反応 / 結晶化 / ケト基 / 還元反応 / 酸化損傷 / 長寿命発光発生型プローブ / 夾雑環境 / RNA検出 / 長寿命発光 / プローブ / 核酸 … More Except Principal Investigator ナノワイヤー / DNA二重鎖 / 光連結法 / DNAナノワーヤー / 金属イオン－核酸 / 単分子導電性 / Hg-DNA wire / Ag-DNA wire / DNA超分子 / 結晶構造 / DNAナノワイヤー / 金属含有DNA二重鎖 / オリゴヌクレオチド合成 / 金属錯体 / 超分子 / matallo-base pair / Crystal structure / DNA/RNA synthesis / Molecule Conductance / crystal structure / metallo-base pairs / metallo-DNA/RNA / Molecular architecture / DNA Supermolecule / DNA nanowire / ポリメラーゼ / 除去 / 検出 / DNA合成酵素 / 等温滴定型カロリメトリー / 結晶解析 / NMR / 機能性核酸 / 金属含有DNA / 水銀イオン / 水銀イオン検出 / 多次元多核種NMR法 / 結晶構造解析 / 水銀イオンの検出 / 水銀イオンの除去 / 環境浄化 Less

細胞内で機能する15N標識RNAグアニン四重鎖プローブの開発とIn-cell 15N-NMRへの応用Principal Investigator
- Principal Investigator
  
  實吉尚郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  University of Miyazaki
がん細胞選択的な細胞死を誘導する合成核酸の開発Principal Investigator
- Principal Investigator
  
  實吉尚郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  University of Miyazaki
Development of cell-permeable oligonucleotides bearing bio-cleavable protecting groupsPrincipal Investigator
- Principal Investigator
  
  Hisao Saneyoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Shiga University of Medical Science
  Kanagawa University
Synthesis and characterization of metallo-DNA nanowire with infinite, uninterrupted one-dimensional metal ions array
- Principal Investigator
  
  Ono Akira
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Inorganic chemistry
- Research Institution
  Kanagawa University
Chemical synthesis of oligonucleotides having keto sugar and their application to chemical biology studyPrincipal Investigator
- Principal Investigator
  
  Saneyoshi Hisao
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Kanagawa University
Development of DNA based heavy metal ions removing membranes and nanowires-structures, properties, applications.
- Principal Investigator
  
  Ono Akira
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional materials/Devices
- Research Institution
  Kanagawa University
Development of long-lived luminogenic probes for detection of DNA/RNA in a crude solutionPrincipal Investigator
- Principal Investigator
  
  HISAO Saneyoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Kanagawa University
  The Institute of Physical and Chemical Research

All 2023 2020 2019 2018 2017 2015 2014 2013 2012 Other

All Journal Article Presentation Patent

[Journal Article] A fish herpesvirus highlights functional diversities among Zα domains related to phase separation induction and A-to-Z conversion2023
- Author(s)
  Diallo Mamadou Amadou、Pirotte Sebastien、Hu Yunlong、Morvan Lea、Rakus Krzysztof、Suarez Nicolas M、PoTsang Lee、Saneyoshi Hisao、Xu Yan、Davison Andrew J、Tompa Peter、Sussman Joel L、Vanderplasschen Alain
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 2 Pages: 806-830
- DOI
  10.1093/nar/gkac761
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05319, KAKENHI-PROJECT-21H02081
[Journal Article] Unusual topological RNA G-quadruplex formed by an RNA duplex: Implications for the dimerization of SARS-CoV-2 RNA.2023
- Author(s)
  Shiyu Wang, Yi Song, Zhiyong He, Hisao Saneyoshi, Rie Iwakiri, Pengyu Xu, Chuanqi Zhao, Xiaogang Qu, Yan Xu.
- Journal Title
  
  Chemical Communications
  
  Volume: 59 Issue: 85 Pages: 12703-12706
- DOI
  10.1039/d3cc03192f
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05319
[Journal Article] Thiol-responsive pro-fluorophore labeling: Synthesis of a pro-fluorescent labeled oligonucleotide for monitoring cellular uptake2020
- Author(s)
  Saneyoshi Hisao、Yamamoto Yuta、Ohta Takayuki、Akai Shoji、Ono Akira
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 30 Issue: 13 Pages: 127222-127222
- DOI
  10.1016/j.bmcl.2020.127222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05486, KAKENHI-PROJECT-17K01966
[Journal Article] Crystal structure of a DNA duplex cross-linked by 6-thioguanine-6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(II) ions and glutathione2019
- Author(s)
  Akira Ono, Takahiro Atsugi, Misato Goto, Hisao Saneyoshi, Takahito Tomori, Kohji Seio, Takenori Dairaku and Jiro Kondo
- Journal Title
  
  RSC Adv
  
  Volume: 9 Issue: 40 Pages: 22859-22862
- DOI
  10.1039/c9ra03515j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03033
[Journal Article] 1.Design, Synthesis and Cellular Uptake of Oligonucleotides Bearing Glutathione-Labile Protecting Groups2019
- Author(s)
  Hisao Saneyoshi, Takayuki Ohta, Yuki Hiyoshi, Takeo Saneyoshi, Akira Ono.
- Journal Title
  
  Organic Letters
  
  Volume: 21 Issue: 4 Pages: 862-866
- DOI
  10.1021/acs.orglett.8b03501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01966, KAKENHI-PROJECT-18H02528
[Journal Article] Novel DNA helical wire containing Hg(II) mediated T:T and T:G pairs2019
- Author(s)
  Akira Ono, Hiroki Kanazawa, Hikari Ito, Misato Goto, Koudai Nakamura, Hisao Saneyoshi, Jiro Kondo
- Journal Title
  
  Angew. Chem. Int. Ed
  
  Volume: 58 Issue: 47 Pages: 16835-16838
- DOI
  10.1002/anie.201910029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03033
[Journal Article] Prodrug型核酸医薬に用いる保護基の開発2019
- Author(s)
  實吉尚郎、小野晶
- Journal Title
  
  Medical Science Digest
  
  Volume: 45 Pages: 4-7
- Data Source
  KAKENHI-PROJECT-17K01966
[Journal Article] Development of Protecting Groups for Prodrug-Type Oligonucleotide Medicines2018
- Author(s)
  Hisao Saneyoshi, Akira Ono
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66 Issue: 2 Pages: 147-154
- DOI
  10.1248/cpb.c17-00696
- NAID
  130006328065
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01966
[Journal Article] A metallo-DNA nanowire with uninterrupted one-dimensional silver array2017
- Author(s)
  Jiro Kondo, Yoshinari Tada, Takenori Dairaku, Yoshikazu Hattori, Hisao Saneyoshi, Akira Ono, Yoshiyuki Tanaka,
- Journal Title
  
  Nature Chemistry
  
  Volume: 9 Issue: 10 Pages: 956-960
- DOI
  10.1038/nchem.2808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03033, KAKENHI-PROJECT-15K13734
[Journal Article] Crystal structure of a DNA duplex containing four Ag(I) ions in consecutive dinuclear Ag(I)-mediated base pairs: 4-thiothymine-2Ag(I)-4-thiothymine2017
- Author(s)
  Akira Ono, Toru Sugawara, Hisao Saneyoshi, Jiro Kondo
- Journal Title
  
  Chemical Communications
  
  Volume: 53 Issue: 86 Pages: 11747-11750
- DOI
  10.1039/c7cc06153f
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03033
[Journal Article] High-resolution crystal structure of AgI-RNA hybrid duplex containing Watson-Crick-like C-AgI-C metallo-base pairs2015
- Author(s)
  Jiro Kondo, Yoshinari Tada, Takenori Dairaku, Hisao Saneyoshi, Itaru Okamoto, Yoshiyuki Tanaka, Akira Ono
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 54 Issue: 45 Pages: 13323-13326
- DOI
  10.1002/anie.201507894
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K13734, KAKENHI-PROJECT-24245037, KAKENHI-PROJECT-14J03684, KAKENHI-PROJECT-24310163
[Journal Article] Structures, physicochemical properties, and applications of T-HgII-T, C-AgI-C, and other metallo-base-pairs.2015
- Author(s)
  Yoshiyuki Tanaka, Jiro Kondo, Vladimir Sychrovsky, Jakub Sebera, Takenori Dairaku, Hisao Saneyoshi, Hidehito Urata, Hidetaka Torigoe and Akira Ono
- Journal Title
  
  Chem. Commun.
  
  Volume: 51 Issue: 98 Pages: 17313-17360
- DOI
  10.1039/c5cc02693h
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05574, KAKENHI-PROJECT-15K13734, KAKENHI-PROJECT-24245037, KAKENHI-PROJECT-14J03684, KAKENHI-PROJECT-24310163, KAKENHI-PROJECT-26288084
[Journal Article] Triphenylphosphinecarboxamide : An Effective Reagent for the Reduction of Azides and its Application to Nucleic Acid Detection2014
- Author(s)
  Hisao Saneyoshi, Tatsuya Ochikubo, Takushi Mashimo, Ken Hatano, Yoshihiro Ito, Hiroshi Abe
- Journal Title
  
  Org lett
  
  Volume: 16 Pages: 30-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24710266
[Journal Article] Triphenylphosphinecarboxamide: An Effective Reagent for the Reduction of Azides and its Application to Nucleic Acid Detection2014
- Author(s)
  Hisao Saneyoshi, Tatsuya Ochikubo, Takushi Mashimo, Ken Hatano, Yoshihiro Ito, Hiroshi Abe.
- Journal Title
  
  Org lett.
  
  Volume: 16 Issue: 1 Pages: 30-33
- DOI
  10.1021/ol402832w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24710266
[Journal Article] A Fluorogenic Peptide Probe Developed by In Vitro Selection Using tRNA Carrying a Fluorognic Amino Acid2014
- Author(s)
  Wei Wang, Takanori Uzawa, Naoya Tochio, Jumpei Hamatsu, Yoshinori Hirano, Seiichi Tada, Hisao Saneyoshi, Takanori Kigawa, Nobuhiro Hayashi, Yutaka Ito, Makoto Taiji, Toshiro Aigaki, Yoshihiro Ito
- Journal Title
  
  Chem Comm
  
  Volume: 50 (22)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24710266
[Journal Article] Synthesis of a nucleoside phosphorodithioate analogue responsive to microenvironmental changes through chiral induction2013
- Author(s)
  Hisao Saneyoshi, Takushi Mashimo, Ken Hatano, Yoshihiro Ito, Hiroshi Abe
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 9 Pages: 1080-1083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24710266
[Journal Article] Polycation-assisted DNA detection by reduction triggered fluorescence probe towards point-of-care testing2013
- Author(s)
  H. Saneyoshi, N. Yoshida, N. Shimada, A. Maruyama, Y. Ito, H. Abe
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 24 Pages: 6851-6853
- DOI
  10.1016/j.bmcl.2013.10.005
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23107007, KAKENHI-PROJECT-24710266
[Journal Article] Polycation-assisted DNA detection by reduction triggered fluorescence amplification probe2013
- Author(s)
  Hisao Saneyoshi, Naohiko Shimada, Atsushi Maruyama, Yoshihiro Ito, Hiroshi Abe
- Journal Title
  
  Bioorg. Med Chem. Lett
  
  Volume: 23 Pages: 6851-6853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24710266
[Journal Article] Long-lived luminogenic probe for detection of RNA in a crude solution of living bacterial cells.2013
- Author(s)
  Hisao Saneyoshi, Yoshihiro Ito, Hiroshi Abe.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 135 Issue: 37 Pages: 13632-13635
- DOI
  10.1021/ja406724k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24710266
[Journal Article] Long-lived luminogenic probe for detection of RNA in a crude solution of living bacterial cells2013
- Author(s)
  Hisao Saneyoshi, Yoshihiro Ito, Hiroshi Abe
- Journal Title
  
  J. Am. Chem. Soc
  
  Volume: 135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24710266
[Patent] 2.ヌクレオシド又はそのヌクレオチドの誘導体、それを構成単位として含むRNA誘導体、核酸医薬、及びRNA誘導体若しくはRNAの製造方法.2018
- Inventor(s)
  小野晶、實吉尚郎
- Industrial Property Rights Holder
  神奈川大学
- Industrial Property Rights Type
  特許
- Patent Publication Number
  2018-184351
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K01966
[Patent] Fluorescent probe for detecting intracellular target mol2012
- Inventor(s)
  Abe, Hiroshi, Hisao Saneyoshi, Ito, Yoshihiro
- Industrial Property Rights Holder
  Riken Corp., Japan
- Industrial Property Rights Type
  特許
- Acquisition Date
  2012-09-13
- Overseas
- Data Source
  KAKENHI-PROJECT-24710266
[Presentation] Unusual topological RNA G-quadruplex formed by an RNA duplex: implications for the dimerization of SARS-CoV-2 RNA.2023
- Author(s)
  Shiyu Wang, Yi Song, Zhiyong He, Hisao Saneyoshi, Rie Iwakiri, Pengyu Xu, Chuanqi Zhao, Xiaogang Qu, Yan Xu.
- Organizer
  第50回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05319
[Presentation] 細胞内で除去される保護基を結合したプロドラッグ型核酸医薬の合成手法の開発研究2020
- Author(s)
  小野晶、三上智紀、鈴木海斗、堀川匡嗣、寺澤一馬、太田貴之、中村康大、實吉尚郎
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] 細胞内還元条件で除去されるRNA糖部保護基の開発2019
- Author(s)
  寺澤一馬、中村康大、小野晶、實吉尚郎
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] 細胞内で蛍光を発する発光標識核酸の合成2019
- Author(s)
  太田貴之、山本祐太、小野晶、實吉尚郎
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] 2' 位に還元環境で脱離する保護基を結合した RNA の合成：プロドラッグ型核酸医薬開発に向けて2019
- Author(s)
  小野晶、中村康大、實吉尚郎
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] Synthesis of cell-permeable and GSH-activatable oligonucleotides2019
- Author(s)
  Takayuki Ohta, Zhaoma Shu, Hiroshi Abe, Akira Ono, Hisao Saneyoshi
- Organizer
  第46回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] Development of a reduction cleavable linker for solid-phase synthesis2019
- Author(s)
  Kazuma Terasawa, Akira Ono, Hisao Saneyoshi
- Organizer
  第46回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] 発蛍光色素が結合したオリゴヌクレオチドの合成2019
- Author(s)
  實吉尚郎、山本祐太、太田貴之、小野晶
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] Novel Structures of modified oligonucleotides and oligonucleotide-metal complexes Akira Ono, Takahiro Atsugi, Hikari Ito, Misato Goto, Hisao Saneyoshi, Jiro Kondo2019
- Author(s)
  Akira Ono, Takahiro Atsugi, Hikari Ito, Misato Goto, Hisao Saneyoshi, Jiro Kondo
- Organizer
  The 46th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03033
[Presentation] 細胞内で活性化されて機能するオリゴヌクレオチドの創製2019
- Author(s)
  實吉尚郎
- Organizer
  第17回有機合成化学協会関西支部賞受賞講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] Preparations and structure elucidations of metallo-DNAs: DNA　nanowire with uninterrupted one-dimensional silver ion array2018
- Author(s)
  Akira Ono, Hisao Saneyoshi, Jiro Kondo, Yoshiyuki Tanaka
- Organizer
  23th International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Invited
- Data Source
  KAKENHI-PROJECT-17H03033
[Presentation] Development of cell-permeable oligonucleotides bearing GSH-activated protecting groups2018
- Author(s)
  Takayuki Ohta, Akira Ono, Hisao Saneyoshi
- Organizer
  23th International Round Table on Nucleosides, Nucleotides and Nucleic Acids (XXIII IRT)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] Synthesis of cell-membrane permeable oligonucleotides bearing GSH-activated protecting groups on the internucleotide linkages2018
- Author(s)
  Hisao Saneyoshi, Takayuki Ohta, Yuki Hiyoshi, Akira Ono
- Organizer
  第45回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] Synthesis of cell-permeable fluorogenic oligonucleotides2018
- Author(s)
  Yuta Yamamoto, Akira Ono, Hisao Saneyoshi
- Organizer
  第44回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] Chemical synthesis of 2'-oxidized nucleic acids2018
- Author(s)
  Hisao Saneyoshi, Akira Ono
- Organizer
  The 98th CSJ Annual Meeting
- Data Source
  KAKENHI-PROJECT-15K21451
[Presentation] 蛍光発生型色素が結合したオリゴヌクレオチドの合成2018
- Author(s)
  實吉尚郎、山本祐太、太田貴之、小野晶
- Organizer
  日本核酸医薬学会第4回年会
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] Synthesis and metal ion binding properties of duplexes containing thymine analogs with 1,2-diamine groups2018
- Author(s)
  Takahiro Atsugi, Hisao Saneyoshi, Akira Ono
- Organizer
  23th International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Invited
- Data Source
  KAKENHI-PROJECT-17H03033
[Presentation] Synthetic study of bio-reduction cleavable linker for oligonucleotides2018
- Author(s)
  Kazuma Terasawa, Akira Ono, Hisao Saneyoshi
- Organizer
  23th International Round Table on Nucleosides, Nucleotides and Nucleic Acids (XXIII IRT)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] 癌細胞内で開裂するリンカーの開発研究2018
- Author(s)
  寺澤一馬、小野晶、實吉尚郎
- Organizer
  日本核酸医薬学会第4回年会
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] 細胞膜透過性を有するグルタチオン応答性プロドラッグ型核酸の合成2018
- Author(s)
  太田貴之、小野晶、實吉尚郎
- Organizer
  日本核酸医薬学会第4回年会
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] Design and synthesis of bio-labile protecting groups for oligonucleotide prodrugs2018
- Author(s)
  Hisao Saneyoshi, Takayuki Ohta, Kazuma Terasawa, Yuta Yamamoto, Akira Ono.
- Organizer
  第44回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] 細胞内還元条件で除去されるRNA糖部保護基の開発2018
- Author(s)
  中村康大、小野晶、實吉尚郎
- Organizer
  日本核酸医薬学会第4回年会
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] Development of reduction-activated protecting groups for siRNA prodrugs2018
- Author(s)
  Kodai Nakamura, Akira Ono, Hisao Saneyoshi
- Organizer
  23th International Round Table on Nucleosides, Nucleotides and Nucleic Acids (XXIII IRT)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] Structure analyses of a novel DNA helical wire containing Hg(II) -mediated T:T and T:G base pairs2018
- Author(s)
  Akira Ono, Hiroki Kanazawa, Hikari Ito, Misato Goto, Hisao Saneyoshi, Jiro Kondo
- Organizer
  第45回国際核酸化学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H03033
[Presentation] Glutathione-labile protecting groups for phosphodiester moieties2018
- Author(s)
  Takayuki Ohta, Yuta Yamamoto, Akira Ono, Hisao Saneyoshi
- Organizer
  第44回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01966
[Presentation] Crystal structures of oligonucleotides having metallo-base pairs2017
- Author(s)
  Akira Ono, Toru Sugawara, Hikari Ito, Misato Goto, Hisao Saneyoshi, Jiro Kondo
- Organizer
  The 44th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03033
[Presentation] Characterization of DNA duplexes containing metal ion mediated base pairs2017
- Author(s)
  Akira Ono, Hisao Saneyoshi, Jiro Kondo, Yoshiyuki Tanaka
- Organizer
  17th Symposium on Chemistry of Nucleic Acid Components
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03033
[Presentation] Synthesis and duplex formation of oligonucleotides with 1,2-diamine groups2017
- Author(s)
  Takahiro Atsugi, Hisao Saneyoshi, Akira Ono
- Organizer
  The 44th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03033
[Presentation] Synthesis of long DNA wires containing metallo-base pairs2017
- Author(s)
  Kenta Ishikawa, Hisao Saneyoshi, Akira Ono
- Organizer
  The 44th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03033
[Presentation] Formations and stabilities of metal ions mediated base pairs in duplexes with various sugar-phosphate backbone structures2015
- Author(s)
  Thoru Sugawara, Yuki Ando, Shion Tanisaki, Shogo Tanakashi, Akane Kumagai, Hisao Saneyoshi, Akira Ono
- Organizer
  The 42th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Egret Himeji, Himeji
- Year and Date
  2015-09-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] Structure of C-Ag(I)-C metallo base pair in RNA duplex2015
- Author(s)
  Yoshinari Tada, Takenori Dairaku, Itaru Okamoto3 Hisao Saneyoshi, Yoshiyuki Tanaka, Akira Ono, Jiro Kondo
- Organizer
  The 42th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Egret Himeji, Himeji
- Year and Date
  2015-09-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] 希土類発光プローブを用いた遺伝子検出プローブの開発2014
- Author(s)
  阿部　洋、實吉尚郎、周東智、伊藤嘉浩
- Organizer
  日本薬学会第134回年会
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-24710266
[Presentation] 希土類発光プローブを用いた遺伝子検出プローブの開発2014
- Author(s)
  阿部洋, 實吉尚郎, 周東智, 伊藤嘉浩
- Organizer
  日本薬学会第134回年会
- Place of Presentation
  熊本大学黒髪キャンパス
- Data Source
  KAKENHI-PROJECT-24710266
[Presentation] アルキル鎖で架橋されたチミンダイマーの合成とHg(II)結合2013
- Author(s)
  高﨑俊一・岡本到・實吉尚郎・小野晶
- Organizer
  第7回バイオ関連化学シンポジウム
- Place of Presentation
  名古屋大学東山キャンパス
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] DNA二重鎖中のシトシン－シトシン塩基対とAg(I)イオンの結合2013
- Author(s)
  杉本真諭・岡本到・實吉尚郎・小野晶
- Organizer
  第7回バイオ関連化学シンポジウム
- Place of Presentation
  名古屋大学東山キャンパス
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] Metal ion binding by modified pyrimidine pairs in DNA duplexes2013
- Author(s)
  Yuki Ando, Hisao Saneyoshi, Itaru Okamoto and Akira Ono
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kanagawa University
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] Binding of Ag(I) ions by cytosine-cytosine pairs in DNA duplexes2013
- Author(s)
  Masato Sugimoto, Hisao Saneyoshi, Itaru Okamoto, Akira Ono
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kanagawa University
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] 隣接基関与を利用する還元反応の開発と核酸検出への応用2013
- Author(s)
  實吉尚郎, 間下琢史, 幡野健, 阿部洋, 伊藤嘉浩
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  立命館大学びわこくさつキャンパス
- Data Source
  KAKENHI-PROJECT-24710266
[Presentation] Synthesis and mercury (II) ion binding of a thymine dimer in which two thymines are linked by an alkyl chain2013
- Author(s)
  Shunichi Takasaki, Hiroyuki Yabe, Hisao Saneyoshi, Itaru Okamoto, Akira Ono
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kanagawa University
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] 隣接基関与を利用する還元反応の開発と核酸検出への応用2013
- Author(s)
  實吉尚郎、間下琢史、幡野健、阿部洋、伊藤嘉浩
- Organizer
  日本化学会第93回春季年会
- Place of Presentation
  立命館大学びわこ・くさつキャンパス
- Data Source
  KAKENHI-PROJECT-24710266
[Presentation] DNA二重鎖中の修飾ピリミジン塩基対の金属イオン結合2013
- Author(s)
  安藤裕輝・岡本到・實吉尚郎・小野晶
- Organizer
  第7回バイオ関連化学シンポジウム
- Place of Presentation
  名古屋大学東山キャンパス
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] Long lived luminogenic DNA probe for DNA/RNA detection2012
- Author(s)
  Hisao Saneyoshi, Hiroshi Abe, Yoshihiro Ito
- Organizer
  20 th International Round Table on Nucleosides, Nucleotides and Nucleic acids
- Place of Presentation
  カナダ　モントリオール
- Data Source
  KAKENHI-PROJECT-24710266
[Presentation] Long lived luminogenic DNA probe for DNA/RNA detection2012
- Author(s)
  Hisao Saneyoshi, Hiroshi Abe, Yoshihiro Ito
- Organizer
  20 th International Round Table on Nucleosides, Nucleotides and Nucleic acids
- Place of Presentation
  Montréal
- Data Source
  KAKENHI-PROJECT-24710266
[Presentation] Metal ion binding properties of modified pyrimidine pairs in duplexes
- Author(s)
  Shion Tanisaki, Akane Kumagai, Hikari Endo, Yuki Ando, Hisao Saneyoshi, Akira Ono*
- Organizer
  The 41th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kitakyushu International Conference Center
- Year and Date
  2014-11-05 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] Mercury ion binding properties of polymers carrying thymine dimer residues
- Author(s)
  Kentaro Ota, Tetsuhiro Chiba, Hisao Saneyoshi, Akira Ono*
- Organizer
  The 41th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kitakyushu International Conference Center
- Year and Date
  2014-11-05 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] Syntheses and characterizations of DNA duplexes having metal ion mediated base pairs
- Author(s)
  Akira Ono, Itaru Okamoto, Hidehito Urata, Hidetake Torigoe, Hisao Saneyoshi, Jiro Kondo, Yoshiyuki Tanaka
- Organizer
  16th Symposium on Chemistry of Nucleic Acid Components
- Place of Presentation
  Cesky Krumlov, Czech Republic
- Year and Date
  2014-06-08 – 2014-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] Metal ion binding by modified pyrimidine pairs arrayed in DNA duplexes
- Author(s)
  Yuki Ando,　Shion Tanisaki,　Hisao Saneyoshi　and　Akira Ono*
- Organizer
  The 41th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kitakyushu International Conference Center
- Year and Date
  2014-11-05 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] yntheses of DNA duplexes containing metal ion mediated base pairs
- Author(s)
  Akira Ono, Itaru Okamoto, Hidehito Urata, Hidetake Torigoe, Hisao Saneyoshi, Jiro Kondo, Yoshiyuki Tanaka
- Organizer
  12th European Biological Inorganic Chemistry Conference
- Place of Presentation
  Zurich, Switzerland
- Year and Date
  2014-08-24 – 2014-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-24245037

1. Ono Akira (10183253)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
2. KONDO Jiro (10546576)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. TANAKA Yoshiyuki (70333797)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. TORIGOE Hidetake (80227678)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. URATA Hidehito (80211085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. MINAKAWA Noriaki (40209820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 岡本到 (40460133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. 山田亮 (20343741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHIMADA Naohiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 丸山厚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 赤井昭二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SANEYOSHI HISAO 實吉 尚郎

實吉 尚郎 サネヨシ ヒサオ

HISAO Saneyoshi 實吉 尚郎

Research Projects

Research Products

Co-Researchers

細胞内で機能する15N標識RNAグアニン四重鎖プローブの開発とIn-cell 15N-NMRへの応用Principal Investigator

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がん細胞選択的な細胞死を誘導する合成核酸の開発Principal Investigator

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Development of cell-permeable oligonucleotides bearing bio-cleavable protecting groupsPrincipal Investigator

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Synthesis and characterization of metallo-DNA nanowire with infinite, uninterrupted one-dimensional metal ions array

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Chemical synthesis of oligonucleotides having keto sugar and their application to chemical biology studyPrincipal Investigator

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Development of DNA based heavy metal ions removing membranes and nanowires-structures, properties, applications.

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Development of long-lived luminogenic probes for detection of DNA/RNA in a crude solutionPrincipal Investigator

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[Journal Article] A fish herpesvirus highlights functional diversities among Zα domains related to phase separation induction and A-to-Z conversion2023

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[Journal Article] Unusual topological RNA G-quadruplex formed by an RNA duplex: Implications for the dimerization of SARS-CoV-2 RNA.2023

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[Journal Article] Thiol-responsive pro-fluorophore labeling: Synthesis of a pro-fluorescent labeled oligonucleotide for monitoring cellular uptake2020

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[Journal Article] Crystal structure of a DNA duplex cross-linked by 6-thioguanine-6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(II) ions and glutathione2019

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[Journal Article] 1.Design, Synthesis and Cellular Uptake of Oligonucleotides Bearing Glutathione-Labile Protecting Groups2019

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[Journal Article] Novel DNA helical wire containing Hg(II) mediated T:T and T:G pairs2019

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[Journal Article] Prodrug型核酸医薬に用いる保護基の開発2019

Author(s)

SANEYOSHI HISAO 實吉尚郎

實吉尚郎サネヨシヒサオ

HISAO Saneyoshi 實吉尚郎