Minakawa Noriaki 南川典昭

… Alternative Names

Researcher Number	40209820
Other IDs
External Links
Affiliation (Current)	2019: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授
Affiliation (based on the past Project Information) *help	2019: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授 2016 – 2018: 徳島大学, 大学院医歯薬学研究部(薬学系), 教授 2015 – 2017: 徳島大学, 大学院医歯薬学研究部, 教授 2015: 徳島大学, 理学部, 教授 2011 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 教授 … More
Review Section/Research Field	Principal Investigator Drug development chemistry / Science and Engineering / Living organism molecular science / Bioorganic chemistry / Biological Sciences / Basic Section 37030:Chemical biology-related / Medium-sized Section 38:Agricultural chemistry and related fields / Biofunction/Bioprocess / Chemical pharmacy / Chemical biology … More Except Principal Investigator … More
Keywords	Principal Investigator RNA / ヌクレオシド / siRNA / RNA干渉 / 核酸医薬 / 4'-thioRNA / 分子認識機構 / RNAi創薬 / アプタマー / ヌクレオチド … More Except Principal Investigator ヌクレオシド / がん化学療法 / アプタマー / NMR / 逆転写酵素 / アジドチミジン / ヌクレアーゼ抵抗性 / miRNA / SELEX / リポソーム / 4'-チオ核酸 / siRNA / 4'-チオDNA / 核酸 / シチジンデアミナーゼ / 構造-活性相関 / ゲノム創薬 / CNDAC / 5ーエチニル・1ーβーDーリボフラノシルイミダゾ-ルー4ーカルボキサミド / 脂肪分化 / aptamer / 水銀イオンの除去 / 2'ーシアノー2'ーデオキシー1ーβーDーアラビノフラノ / 肥満 / 自然免疫活性化 / アンチセンス / ナノ粒子 / VEGF / heterogeneity / ドラッグデリバリー / ヌクレアーゼ抵抗性核酸 / ポリメラーゼ / 4-チオRNA / 核酸医薬 / 免疫 / U1 snRNA / 抗ウィルス薬 / 4-チオ核酸 / RNAウイルス / 4'-チオRNA / 制癌作用 / nuclease stability / MEND / オリゴヌクレオチド / 4'-thioRNA / リバビリン / 転写調節 / ホタルルシフェラーゼ / アリ-ルアルコ-ル / 核酸デリバリー / RNAi / 水銀イオン検出 / 膜透過性ペプチド / ヌ-ドマウス / DNA合成酵素 / Dicer / EICA / エチニルー1ーβーDーリボフラノシルイミダゾ-ルー4ーカルボキサミド / シルシトシン(CNDAC) / 2'-O-メチル-4'-チオリボヌクレオシド / EICAR / ヌクレアーゼ祇抗性核酸 / DDS / 2'-0-メチル-4'-チオリポヌクレオシド / 微弱電流 / Antimetabolite / 等温滴定型カロリメトリー / ナノワイヤー / クロスリンク / 3-Deazaaristeromycin / スプライス / AMPK / 急性呼吸器疾患 / microRNA / 4'-thonucleoside / RNA / リンパ節転移 / 検出 / MT-4細胞 / ベクター / アディポカイン / 3ーデアザアリステロマイシン / マクロピノサイトーシス / DMDC / Nucleoside / 水銀イオン / 5-ethynyl-1-beta-D-ribo-furanosylimidazole-4 / RNase A耐性 / がん治療 / T7 RNA polymerase / 薬物送達システム / ターゲッティング / 結晶構造解析 / デオキシシチジンキナーゼ / 発現制御 / KOD dash / antisense RNA / 遺伝子デリバリー / マクロビノサイトーシス / 細胞内動態制御 / 薬学 / 2'-O-メチル-4'-チオリポヌクレオシド / 多次元多核種NMR法 / RNA-virus / SNALP / RSウィルス / Rnase A耐性 / Ribavirin / Apo-B / 結晶解析 / RNA型ウィルス / 酵素合成 / 4'-thioDNA / 除去 / 水銀イオンの検出 / Chemotherapy / 制癌性ヌクレオシド / si RNA / コレステロール / 代謝拮抗剤 / ゾ-ルー4ーカルボキサミド / HIV / 微弱電流処理 / D4C / 抗HIV活性 / エイズ / リアルタイムイメージング / 立体配座 / 金属含有DNA / 抗HIV作用 / 化学合成 / 機能性核酸 / 2'-0-メチル-4'-チオリボヌクレオシド / 化学療法剤 / Anti-PEG IgM / D4T / リン脂質 / mRNA検出 / 脂肪細胞 / thermal stability / RNA干渉 / RNAウィルス / 環境浄化 / 分子認識 / DNAポリメラーゼ Less

「食べるマイクロRNAを創る」　ー機能性食品としての核酸ーPrincipal InvestigatorOngoing
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  The University of Tokushima
iRedによる核酸創薬研究を加速させる外部刺激応答型核酸ナノ構造体の創製Principal InvestigatorOngoing
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  The University of Tokushima
微弱電流によるナノ粒子の腫瘍内浸透・細胞取込み亢進による革新的がん治療技術の確立Ongoing
- Principal Investigator
  
  小暮健太朗
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokushima
高いスプライス異常修復能を有した改変U1 snRNA発現ベクターの構築と疾病治療Ongoing
- Principal Investigator
  
  山崎尚志
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokushima
Study of immunological response to nucleic acid delivery system
- Principal Investigator
  
  ISHIDA Tatsuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokushima
Investigation of practical anticancer strategy based on chemically synthesized iRed/iPedPrincipal Investigator
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
Mechanisms of adipose tissue-specific expression and action of D-dopachrome tautomrase
- Principal Investigator
  
  IWATA Takeo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
ナノ核酸デバイスを用いた自然免疫応答発現機構の網羅的解析Principal Investigator
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokushima
Development of DDS system based on the intracellular enviroment responsive aptamersPrincipal Investigator
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  The University of Tokushima
Development of anti-miRNA oligonucleotides with stable duplexes to control cardiac diseases.
- Principal Investigator
  
  Komatsu Yasuo
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
ケミカルデバイスを利用したｓｉＲＮＡによって誘起される分子反応の発現機構解明Principal Investigator
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokushima
Development of DNA based heavy metal ions removing membranes and nanowires-structures, properties, applications.
- Principal Investigator
  
  Ono Akira
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional materials/Devices
- Research Institution
  Kanagawa University
Development of a novel RNAi medicine based on shRNA expression mini-plasmidPrincipal Investigator
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
Development of a novel approach toward nucleic acids-based therapeuticsPrincipal Investigator
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
Synthesis and properties of 4'-selenoRNA based on biological equivalencePrincipal Investigator
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Hokkaido University
DNA・mRNAの細胞内高感度可視化情報に基づく高性能人工遺伝子べクターの創製
- Principal Investigator
  
  秋田英万
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
Development of multifunctional envelope-type nano device encapsulating highly nuclease resistant oligonucleotides
- Principal Investigator
  
  MATSUDA Akira
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Development of chemical tools for nucleic acide-proteim interactions and its utility for siRNA medicinePrincipal Investigator
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Hokkaido University
4'-thioRNAによるRNA干渉の基礎研究とがん遺伝子への展開Principal Investigator
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
4'-thioRNAによるRNA干渉の基礎研究とがん遺伝子治療への展開Principal Investigator
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Basic Studies of Molecular Recognition by 4'-Thionucleic acids
- Principal Investigator
  
  MATSUDA Akira
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
In vitro selection of functional RNAs using 4'-thioNTPPrincipal Investigator
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  HOKKAIDO UNIVERSITY
Pd触媒を用いた新規環状2本鎖DNAの合成と機能性デコイ分子の創製Principal Investigator
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University
リンパ節転移がんに有効な制がん剤ドラッグデリバリーシステムの開発Principal Investigator
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hokkaido University
核酸の立体配座固定のための新手法の開発と応用Principal Investigator
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Hokkaido University
リンパ節転移がんに対する化学療法剤の開発
- Principal Investigator
  
  周東智
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
万能型水素結合能を持つ三環性イミダゾピリドピリミジンヌクレオシドの合成と性質Principal Investigator
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Hokkaido University
新規抗腫瘍性ヌクレオシドDMDCおよびCNDACの作用機序の解明
- Principal Investigator
  
  松田彰
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
逆転写酵素阻害を基本戦略とする抗HIV剤の開発研究
- Principal Investigator
  
  松田彰
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
DNA鎖自己切断能をもつヌクレオシド系自殺基質の設計
- Principal Investigator
  
  松田彰
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
不合飽和官能基をもつヌクレオシドの制癌活性機序
- Principal Investigator
  
  上田亨
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
逆転写酵素阻害を基本戦略とする抗HIV剤の開発研究
- Principal Investigator
  
  上田亨
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Developmental Studies of Nucleosidic Anti-RNA Virus Drugs
- Principal Investigator
  
  MATSUDA Akira, 上田亨
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University

[Book] 核酸医薬の創製と応用展開2015
- Author(s)
  田良島典子、南川典昭
- Total Pages
  278
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-15H04656
[Book] 核酸医薬の創製と応用展開2015
- Author(s)
  田良島典子、南川典昭
- Total Pages
  278
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PUBLICLY-26107713
[Book] スーパー核酸 : 4'-チオ核酸の合成から核酸医薬開発に向けた基礎研究の展開,化学フロンテイア「創薬をめざす有機合成戦略 : 進化する医薬品づくり」(宍戸, 宏造, 新藤, 充)2007
- Author(s)
  南川典昭, 松田彰
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-18109001
[Book] 化学フロンティア19 創薬をめざす有機合成戦略2007
- Author(s)
  南川典昭, 松田彰
- Total Pages
  201
- Publisher
  化学同人
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18510180
[Book] 核酸医薬の創製をめざして : 「バイオとナノの融合II,新生命科学への応用」(北海道大学COE研究成果編集委員会)2007
- Author(s)
  松田彰, 南川典昭
- Publisher
  北海道大学
- Data Source
  KAKENHI-PROJECT-18109001
[Book] Frontiers in Organic Chemistry2005
- Author(s)
  Minakawa, N., et al.
- Total Pages
  23
- Publisher
  Bentham Science Publishers
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209003
[Book] RNAi法とアンチセンス法 RNAの科学と応用「RNAi研究において有機化学ができること:その現状と展望」(関根光雄・多比良和誠:編)
- Author(s)
  南川典昭
- Publisher
  (in press)
- Data Source
  KAKENHI-PROJECT-16023209
[Journal Article] The AMPK/mTOR pathway is involved in D-dopachrome tautomerase gene transcription in adipocytes differentiated from SGBS cells, a human preadipocyte cell line2017
- Author(s)
  岩田武男、栗林恭子、中園雅彦、田良島典子、南川典昭、水澤典子、木戸理恵、吉本勝彦
- Journal Title
  
  Cytokine
  
  Volume: 96 Pages: 195-202
- DOI
  10.1016/j.cyto.2017.04.017
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11040, KAKENHI-PROJECT-17K17287
[Journal Article] Synthesis of 4’-selenoribonucleosides, the building blocks of 4’-selenoRNA, using a hypervalent iodine.2017
- Author(s)
  Noriko Saito-Tarashima, Masashi Ota, Noriaki Minakawa
- Journal Title
  
  Curr. Protoc. Nucleic Acid Chem.
  
  Volume: 70 Pages: 1-21
- DOI
  10.1002/cpnc.34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04656
[Journal Article] A ‘catch and release’ strategy towards HPLC-free purification of synthetic oligonucleotides using a phosphoramidite unit possessing a photocleavable azide linker.2017
- Author(s)
  Yosuke Igata, Noriko Saito-Tarashima, Daiki Matsumoto, Kazuyuki Sagara, Noriaki Minakawa
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 25 Pages: 5962-5967
- DOI
  10.1016/j.bmc.2017.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04656
[Journal Article] Groove modification of siRNA duplexes to elucidate siRNA-protein interactions using 7-bromo-7-deazaadenosine and 3-bromo-3-deazaadenosine as chemical probes.2016
- Author(s)
  Noriko Saito-Tarashima, Hirotaka Kira, Tomoya Wada, Kazuya Miki, Shiho Ide, Naoshi Yamazaki, Akira Matsuda, Noriaki Minakawa
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 14 Pages: 11096-11105
- DOI
  10.1039/c6ob01866a
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04656, KAKENHI-PROJECT-15H06446
[Journal Article] Practical synthesis of 4'-selenopurine nucleosides by combining chlorinated purines and 'armed' 4-selenosugar.2016
- Author(s)
  Kazuki Ishii, Noriko Saito-Tarashima , Masashi Ota, Seigi Yamamoto, Yasuko Okamoto, Yoshiyuki Tanaka, Noriaki Minakawa
- Journal Title
  
  Tetrahedron
  
  Volume: 72 Pages: 6589-6594
- DOI
  10.1016/j.tet.2016.08.071
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04656, KAKENHI-PROJECT-15H06446, KAKENHI-PROJECT-15K13734
[Journal Article] The Novel Functional Nucleic Acid iRed Effectively Regulates Target Genes Following Cytoplasmic Delivery by Faint eEectric Treatment.2016
- Author(s)
  Mahadi Hasan, Noriko Tarashima, Koki Fujikawa, Takashi Ohgita, Susumu Hama, Tamotsu Tanaka, Hiroyuki Saito, Noriaki Minakawa, Kentaro Kogure
- Journal Title
  
  Sci. Technol. Adv. Mater.
  
  Volume: 17 Pages: 554-562
- DOI
  10.1080/14686996.2016.1221726
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-WRAPUP-16H01692, KAKENHI-PROJECT-15H04656, KAKENHI-PROJECT-15H06446, KAKENHI-PROJECT-25293006
[Journal Article] Gene silencing using 4'-thioDNA as an artificial template to synthesize short-hairpin RNA without inducing a detectable innate immune response2016
- Author(s)
  Noriko Tarashima, Hidenori Ando,Takamitsu Kojima,Nozomi Kinjo,Yosuke Hashimoto,Kazuhiro Furukawa,Tatsuhiro Ishida, Noriaki Minakawa
- Journal Title
  
  Mol. Ther. Nucl. Acids
  
  Volume: 5
- DOI
  10.1038/mtna.2015.48
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04656, KAKENHI-PROJECT-15H06446
[Journal Article] Faithful PCR amplification of an unnatural base pair analog, ImNN:NaOO, with four hydrogen bonds.2015
- Author(s)
  Tarashima, N., Komatsu, Y., Furukawa, K. and Minakawa, N.
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 21 Pages: 10688-10695
- DOI
  10.1002/chem.201501484
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293030
[Journal Article] Transcription of 4′-thioDNA templates to natural RNA in vitro and in mammalian cells2015
- Author(s)
  Maruyama, H.; Furukawa, K.; Kamiya, H.; Minakawa, N.; Matsuda, A.
- Journal Title
  
  Chem. Commun
  
  Volume: 51 Pages: 7887-7890
- DOI
  10.1039/c4cc08862j
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-25282144, KAKENHI-PROJECT-15H04656
[Journal Article] Faithful PCR Amplification of an Unnatural Base-Pair Analogue with Four Hydrogen Bond2015
- Author(s)
  Noriko Tarashima,Yasuo Komatsu,Kazuhiro Furukawa,and Noriaki Minakawa*
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 21 Pages: 10688-10695
- DOI
  10.1002/chem.201583062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04656, KAKENHI-PROJECT-15H06446
[Journal Article] Synthesis of DNA fragments containing 2’-deoxy-4’-selenonucleoside units using DNA polymerases: comparison of dNTPs with O, S and Se at the 4’-position in replication.2015
- Author(s)
  Noriko Tarashima, Tatsuya Sumitomo, Hidenori Ando, Kazuhiro Furukawa, Tatsuhiro Ishida and Noriaki Minakawa*
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 13 Pages: 6949-6952
- DOI
  10.1039/c5ob00941c
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04656, KAKENHI-PROJECT-15H06446, KAKENHI-PROJECT-26630432
[Journal Article] The first synthesis of fully-modified 4’-selenoRNA and 2’-OMe-4’-selenoRNA based on the mechanistic considerations of an unex-pected strand-break.2014
- Author(s)
  Tarashima, N.; Hayashi, K.; Terasaki, M.; Tanike, H.; Inagaki, Y.; Fukuda, Y.; Furukawa, K.; Matsuda, A.; Minakawa,
- Journal Title
  
  Org. Lett.
  
  Volume: 16 Pages: 4710-4713
- DOI
  10.1021/ol502077h
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06728, KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-24390027
[Journal Article] Development of a New Dumbbell-Shaped Decoy DNA Using a Combination of the Unnatural Base Pair ImON:NaNO and a CuAAC Reaction2014
- Author(s)
  Yosuke Higuchi, Kazuhiro Furukawa, Tadashi Miyazawa, and Noriaki Minakawa
- Journal Title
  
  Bioconjugate Chem.
  
  Volume: 25 Pages: 1360-1369
- DOI
  10.1021/bc500225r
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390027
[Journal Article] The systematic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice.2014
- Author(s)
  Hiroto Hatakeyama, Manami Murata, Yusuke Sato, Mayumi Takahashi, Noriyuki Minakawa, Akira Matsuda, Hideyoshi Harashima
- Journal Title
  
  Journal of Controled Release
  
  Volume: 173 Pages: 43-50
- DOI
  10.1016/j.jconrel.2013.10.023
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-23249008, KAKENHI-PUBLICLY-24107502, KAKENHI-PUBLICLY-24107518
[Journal Article] Chemistry, properties, and in vitro and in vivo applications of 2’-O-methoxyethyl-4’-thioRNA, a novel hybrid type of chemically modified RNA2014
- Author(s)
  Saito, Y.; Hashimoto, Y.; Arai, M.; Tarashima, N.; Miyazawa, T.; Miki, K.; Takahashi, M.; Furukawa, K.; Yamazaki, N.; Matsuda, A.; Ishida,T.; Minakawa, N.
- Journal Title
  
  ChemBioChem.
  
  Volume: 15 Pages: 2535-2540
- DOI
  10.1002/cbic.201402398
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06728, KAKENHI-PROJECT-23249008, KAKENHI-PUBLICLY-26107713
[Journal Article] PCR Amplification of 4′-ThioDNA Using 2′-Deoxy-4′-thionucleoside 5′-Triphosphates2013
- Author(s)
  Kojima, T. ; Furukawa, K. ; Maruyama, H. ; Inoue, N. ; Tarashima, N. ; Matsuda, A. ; Minakawa, N.
- Journal Title
  
  ACS Synthetic Biol.
  
  Volume: 2 Pages: 529-536
- DOI
  10.1021/sb400074w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06728, KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-24390027
[Journal Article] 4'・チオDNAを用いたRNA創薬2013
- Author(s)
  南川典昭
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 133 Pages: 53-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390027
[Journal Article] In vitro optimization of 2'-OMe-4'-thioribonucleoside-modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle2013
- Author(s)
  Mayumi Takahashi, Naoki Yamada, Hiroto Hatakeyama, Manami Murata, Yusuke Sato, Noriaki Minakawa, Hideyoshi Harashima, Akira Matsuda
- Journal Title
  
  NUcleic Acids Res.
  
  Volume: 41 Pages: 10659-10667
- DOI
  10.1093/nar/gkt823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05557, KAKENHI-PUBLICLY-24107502, KAKENHI-PUBLICLY-24107518, KAKENHI-PROJECT-24390027
[Journal Article] Synthesis of a novel 1,2-dithianenucleoside via Pummerer-like reaction, followed by Vorbruggen glycosylation between a 1,2-dithiane derivative and uracil2013
- Author(s)
  Miyazawa, T. ; Umezaki. K. ; Tarashima, N. ; Furukawa, K. : Ooi, T. ; Minakawa, N.
- Journal Title
  
  Chem. Commun.
  
  Volume: 49 Pages: 7851-7853
- DOI
  10.1039/c3cc44848g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06728, KAKENHI-PROJECT-24390027
[Journal Article] Gene suppression via Ul small nuclear RNA interference (U1i) machinery using oligonucleotides containing 2'-modified-4'-thionucleosides2013
- Author(s)
  Kukuchi, Y. ; Yamazaki, N. ; Tarashima, N. ; Furukawa, K. : Takiguchi, Y. ; Itoh, K. ; Minakawa, N.
- Journal Title
  
  Bioorg. & Medicin. Chem
  
  Volume: 21 Pages: 5292-5296
- DOI
  10.1016/j.bmc.2013.06.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06728, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23390140, KAKENHI-PROJECT-24390027, KAKENHI-PROJECT-24659262, KAKENHI-PUBLICLY-25110722
[Journal Article] Intracellular stability of 2'-OMe-4' -thioribonucleoside modified siRNA leads to long-term RNAi effect2012
- Author(s)
  Mayumi Takahashi
- Journal Title
  
  Nucleic Acids Res
  
  Volume: (in press) Pages: 5787-5793
- DOI
  10.1093/nar/gks204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J01717, KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-23659054, KAKENHI-PROJECT-24390027
[Journal Article] A practical post-modification synthesis of oligodeoxynucleotides containing 4,7-diaminoimidazo [5', 4' : 4, 5]pyrido[2,3-d]pyrimidine nucleoside2012
- Author(s)
  Noriko Tarashima, Yosuke Higuchi, Yasuo Komatsu, and Noriaki Minakawa
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 20 Pages: 7095-7100
- DOI
  10.1016/j.bmc.2012.10.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659054, KAKENHI-PROJECT-24390027
[Journal Article] Synthesis and characterization of oligodeoxynucleotides containing a novel tetraazabenzo[cd]azulene:naphthyridine base pair2011
- Author(s)
  Yasuyuki Hirama, Noriaki Minakawa, and Akira Matsuda
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 19 Pages: 352-358
- DOI
  10.1016/j.bmc.2010.11.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659054
[Journal Article] New imidazopyridopyrimidine: naphthyridine base-pairing motif, ImN^<N>:NaO^<O>, consisting of a DAAD:ADDA hydrogen bonding pattern, markedly stabilize DNA duplexes2011
- Author(s)
  Kuramoto, K.
- Journal Title
  
  Chem. Commun
  
  Volume: 47 Pages: 10818-10820
- DOI
  10.1039/c1cc13805g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-23659054
[Journal Article] Synthesis and properties of a novel nucleoside derivative possessing a 2,3,5,6-tetraazabenzo[cd]azulene skelton.2010
- Author(s)
  Y.Hirama, H.Abe, N.Minakawa, A.Matsuda
- Journal Title
  
  Tetrahedron 66
  
  Pages: 8402-8406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611001
[Journal Article] A convenient RNA synthesis using a phosphoramidite possessing a biotinylated photocleavable group.2010
- Author(s)
  K.Tomaya, M.Takahashi, N.Minakawa, A.Matsuda
- Journal Title
  
  Org.Lett. 131
  
  Pages: 3836-3839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611001
[Journal Article] Convenient RNA synthesis using a phosphoramidite possessing a biotinylated photocleavable group.2010
- Author(s)
  Tomaya K.; Takahashi M.; Minakawa N.; Matsuda A.
- Journal Title
  
  Org.Lett. 12
  
  Pages: 3836-3839
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Selective recognition of unnatural imidazopyridopyrimidine : naphthyridine base pairs consisting of four hydrogen bonds by the Klenow fragment.2009
- Author(s)
  Minakawa N.; Ogata S.; Takahashi M.; Matsuda A.
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 1644-1645
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Synthesis and characterization of 2'-modified-4'-thioRNA : a comprehensive comparison of nuclease stability.2009
- Author(s)
  M.Takahashi, N.Minakawa, A.Matsuda
- Journal Title
  
  Nucleic Acids Res. 37
  
  Pages: 1353-1362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611001
[Journal Article] Unnatural imidazopyridopyrimidine : naphthyridine base pairs : selective incorporation and extension reaction by DNA polymerase2009
- Author(s)
  N.Minakawa, et al.
- Journal Title
  
  Nucleic Acids Symp.Ser. 53
  
  Pages: 125-126
- Data Source
  KAKENHI-PROJECT-20611001
[Journal Article] Selective recognition of unnatural imidazopyridopyrimidine : naphthyridine base pairs consisting of four hydrogen bonds by the Klenow fragment2009
- Author(s)
  N.Minakawa, et al.
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 1644-1645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611001
[Journal Article] Selective recognition of unnatural imidazopyridopyrimidine : naphthyridine base pairs consisting of four hydrogen bonds by the Klenow fragment.2009
- Author(s)
  N.Minakawa, S.Ogata, M.Takahashi, A.Matsuda
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 1644-1645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611001
[Journal Article] Synthesis and characterization of 2'-modified-4'-thioRNA : a comprehensive comparison of nuclease stability2009
- Author(s)
  Takahashi, M. ; Minakawa, N. ; Matsuda, A.
- Journal Title
  
  Nucleic Acids Res. 37
  
  Pages: 1353-1362
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Synthesis and characterization of 2'-modified-4'-thioRNA : a comprehensive comparison of nuclease stability.2009
- Author(s)
  Takahashi M.; Minakawa N.; Matsuda A.
- Journal Title
  
  Nucleic Acids Res. 37
  
  Pages: 1353-1362
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Selective recognition of unnatural imidazopyridopyrimidine : naphthyridine base pairs consisting of four hydrogen bonds by the Klenow fragment.2009
- Author(s)
  N.Minakawa, et al.
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 1644-1645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Unnatural imidazopyridopyrimidine : naphthyridine base pairs : selective incorporation and extension reaction by Deep Vent (exo-) DNA polymerase.2009
- Author(s)
  Ogata S.; Takahashi M.; Minakawa N.; Matsuda A.
- Journal Title
  
  Nucleic Acids Res. 37
  
  Pages: 5602-5609
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Oligodeoxynucleotides containing 3-bromo-3-deazaadenine and 7-bromo-7-deazaade nine nucleosides as chemical probes to investigate DNA-protein interaction.2008
- Author(s)
  N. Minakawa, et. al.
- Journal Title
  
  ChemBioChem 9
  
  Pages: 464-470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18510180
[Journal Article] Oligodeoxynucleotides containing 3-bromo-3-deazaadenine and 7-bromo-7-deazaadenine nucleosides as chemical probes to investigate DNA-protein interaction.2008
- Author(s)
  N. Minakawa, Y. Kawano, S. Murata, N. Inoue, A. Matsuda
- Journal Title
  
  ChemBioChem 9
  
  Pages: 464-470
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510180
[Journal Article] Oligodeoxynucleotides containing 3-bromo-3-deazaadenine and 7-bromo-7-deazaadenine nucleosides as chemical probes to investigate DNA-protein interaction.2008
- Author(s)
  N.Minakawa, Y.Kawano, S.Murata, N.Inoue, A.Matsuda
- Journal Title
  
  ChemBioChem 9
  
  Pages: 464-470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611001
[Journal Article] Oligonucleotides containing 3-bromo-3-deazaadenine and 7-bromo-7-deazaadenine 2'-deoxynucleosides as chemical probes to investigate DNA-protein interactions.2008
- Author(s)
  Minakawa N.; Kawano Y.; Murata S.; Inoue N.; Matsuda A.
- Journal Title
  
  ChemBioChem. 9
  
  Pages: 464-470
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Investigations toward the selection of fully-modified 4'-thioRNA aptamers : optimization of in vitro transcription step in the presence of 4'-thioNTPs2008
- Author(s)
  Minakawa, N. ; Sanji, M. ; Kato, Y. ; Matsuda, A.
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 9450-9456
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Oligodeoxynucleotides containing 3-bromo-3-deazaadenine and 7-bromo-7-deazaadenine nucleosides as chemical probes to investigate DNA-protein interaction.2008
- Author(s)
  N. Minakawa , et. al.
- Journal Title
  
  ChemBioChem 9
  
  Pages: 464-470
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18510180
[Journal Article] Unexpected A-form formation of 4'-thioDNA in solotion, as revealed by NMR, and the implication on the mechanism of nuclease-resistance2008
- Author(s)
  Matsugami, A. ; Ohyama, T. ; Inada, M. ; Inoue, N. ; Minakawa, N. ; Matsuda, A. ; Katahira, M.
- Journal Title
  
  Nucleic Acids Res. 36
  
  Pages: 1805-1812
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Investigations toward the selection of fullymodified 4'-thioRNA aptamers : optimization of in vitro transcription step in the presence of 4'-thioNTPs.2008
- Author(s)
  Minakawa N.; Sanji M.; Kato Y.; Matsuda A.
- Journal Title
  
  Bioorg.Med.Chem. 16
  
  Pages: 9450-9456
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Synthesis ans crystal structure of 2'-deoxy-2'-fluoro-4'-thioribonucleosides : substrates for the synthesis of novel modified RNAs.2008
- Author(s)
  Takahashi M.; Daidouji S.; Shiro M.; Minakawa N.; Matsuda A.
- Journal Title
  
  Tetrahedron 64
  
  Pages: 4313-4324
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Investigations toward the selection of fully-modified 4'-thioRNA aptamers: optimization of in vitro transcription step in the presence of 4'-thio NTPs2008
- Author(s)
  N. Minakawa, et.al.
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 9450-9456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Ohgonucleotides containing 3 bromo-3-deazaadenine and 7-bromo-7-deazaadenine 2'-deoxynucleosides as chemical probes to investigate DNA-protein interactions2008
- Author(s)
  N. Minakawa, et.al.
- Journal Title
  
  Chem Bio Chem 9
  
  Pages: 464-470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Unexpected A-form formation of 4'-thioDNA in solotion, as revealed by NMR, and the implication on the mechanism of nucleaseresistance.2008
- Author(s)
  Matsugami A.; Ohyama T.; Inada M.; Inoue N.; Minakawa N.; Matsuda A.; Katahira M.
- Journal Title
  
  Nucleic Acids Res. 36
  
  Pages: 1805-1812
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Unxepected A-form formation of 4'-thioDNA in solution, revealed by NMR, and the implications as to the mechanism of nuclease-resistance.2008
- Author(s)
  A.Matsugami, T.Ohyama, M.Inada, N.Inoue, N.Minakawa, A.Matsuda, M.Katahira
- Journal Title
  
  Nucleic Acids Res. 36
  
  Pages: 1805-1812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611001
[Journal Article] Amplification of 4'-thioDNA in the presence of 4'-thio-Dttp and 4'-thio-dCTP, and 4'-thioDNA-directed transcription in vitro and in mammalian cells2007
- Author(s)
  Inoue, N. ; Shionoya, A. ; Minakawa, N. ; Ogawa, N. ; Matsuda, A.
- Journal Title
  
  J. Am. Chem. Soc. 129
  
  Pages: 15424-15425
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Study of modification pattern-RNAi activity relationships using siRNAs modified with 4'-thioribonucleosides, finding an effective modification irrespective of target sequence.2007
- Author(s)
  Hoshika S.; Minakawa N.; Shionoya A.; Imada K.; Ogawa N.; Matsuda A.
- Journal Title
  
  ChemBioChem. 8
  
  Pages: 2133-2138
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Amplification of 4'-thioDNA in the presence of 4'-thio-dTTP and 4'-thio-dCTP, and 4'-thioDNA-directed transcription in vitro and in mammalian cells.2007
- Author(s)
  Inoue N.; Shionoya A.; Minakawa N.; Ogawa N.; Matsuda A.
- Journal Title
  
  J.Am.Chem. Soc. 129
  
  Pages: 15424-15425
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Study of Modification Pattern-RNAi Activity Relationships by Using siRNAs Modified with 4'-Thioribonucleosides.2007
- Author(s)
  S. Hoshika, N. Minakawa, A. Shionoya, K. Imada, N. Ogawa, A. Matsuda
- Journal Title
  
  ChemBioChem 8
  
  Pages: 2133-2138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510180
[Journal Article] Oligonucleotides containing 3-bromo-3-deazaadenine and 7-bromo-7-deazaadenine 2'-deoxynucleosides as chemical probes to investigate DNA-protein interactions.2007
- Author(s)
  N. Minakawa, et al.
- Journal Title
  
  Chem Bio Chem. 9
  
  Pages: 464-470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Amplification of 4'-ThioDNA in the Presence of 4'-Thio-dTTP and 4'-Thio-dCTP, and 4'-ThioDNA-Directed Transcription in Vitro and in Mammalian Cells2007
- Author(s)
  N. Inoue, A. Shionoya, N. Minakawa, A. Kawakami, N. Ogawa, A. Matsuda
- Journal Title
  
  J. Am. Chem. Soc. 129
  
  Pages: 15424-15425
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510180
[Journal Article] Synthesis and properties of 4'-thioDNA: unexpected RNA-like behavior of 4'-thioDNA.2006
- Author(s)
  Inoue N.; Minakawa N.; Matsuda A.
- Journal Title
  
  Nucleic Acids Res. 34
  
  Pages: 3476-3483
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Four hydrogen-bonding motifs in oligonucleotides2006
- Author(s)
  N.Minakawa, et al.
- Journal Title
  
  ARKIVOC 7
  
  Pages: 326-337
- Data Source
  KAKENHI-PROJECT-18510180
[Journal Article] Synthesis and properties of 4'-thioDNA : unexpected RNA-like behavior of 4'-thioDNA2006
- Author(s)
  Inoue, N. ; Minakawa, N. ; Matsuda, A.
- Journal Title
  
  Nucleic Acids Res. 34
  
  Pages: 3476-3483
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Synthesis and characterization of oligodeoxynucleotides containing naphthyridine : imidazopyridopyrimidine base pairs at their sticky ends. Application as thermally stabilized decoy molecules.2006
- Author(s)
  Hikishima S.; Minakawa N.; Kuramoto K.; Ogata S.; Matsuda A.
- Journal Title
  
  ChemBioChem 7
  
  Pages: 1970-1975
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] 4'-Thionucleic Acids : Chemistry, Properties, and Applications for Developing Functional Oligonucleotides2005
- Author(s)
  N.Minakawa et al.
- Journal Title
  
  Frontiers in Organic Chemistry 1(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510169
[Journal Article] An Improved large scale synthesis of 1,4-anhydro-4-thio-D-ribitol.2003
- Author(s)
  N.Minakawa et al.
- Journal Title
  
  Tetrahedron 59
  
  Pages: 1699-1702
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510169
[Journal Article] 4'-Thionucleic Acids : Chemistry, Properties, and Applications for Developing Functional Oligonucleotides
- Author(s)
  Minakawa, N. et al.
- Journal Title
  
  Frontiers in Organic Chemistry (in press)
- Data Source
  KAKENHI-PROJECT-15510169
[Journal Article] 4'-Thionucleic Acids : Chemistry, Properties, and Applications for Developing Functional Oligonucleotides
- Author(s)
  Minakawa, N. et al.
- Journal Title
  
  Frontiers in Organic Chemistry (in press)
- Data Source
  KAKENHI-PROJECT-16023209
[Journal Article] 4'-Thionucleic Acids : Chemistry, Properties, and Applications for Developing Functional Oligonucleotides.
- Author(s)
  N.Minakawa et al.
- Journal Title
  
  Frontiers in Organic Chemistry (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510169
[Presentation] 微弱電流処理を利用した機能性核酸の細胞内取り込みの検討2018
- Author(s)
  大島康文、Mahadi Hasan、田良島典子、濱進、福田達也、田中保、南川典昭、小暮健太朗
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] iRedを骨格とした核酸ナノ構造体の開発研究2018
- Author(s)
  高橋知樹、山本清義、江村智子、日高久美、田良島典子、遠藤政幸、杉山弘、南川典昭
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] Effective cellular delivery of intelligent shRNA expression device by faint electricity2017
- Author(s)
  Kogure K, Tarashima N, Fujikawa K, Oshima Y, Torao T, Mimura M, Hasan M, Hama S, Tanaka T, Saito H, Minakawa N
- Organizer
  6th FIP Pharmaceutical Sciences World Congress (PSWC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03976
[Presentation] Synthesis and properties of 4’-selenoRNA2017
- Author(s)
  Masashi Ota, Noriko Saito-Tarashima, Noriaki Minakawa
- Organizer
  The 44th International Symposium on Nucleic Acids Chemistry (ISNAC 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] 微弱電流による新規核酸iRedの細胞内送達と遺伝子発現制御2017
- Author(s)
  小暮健太朗、藤川昂樹、Mahadi Hasan、濱　進、田中　保、田良島典子、南川典昭
- Organizer
  遺伝子・デリバリー研究会第１７回シンポジウム
- Data Source
  KAKENHI-PROJECT-17H03976
[Presentation] 4’-セレノRNAの合成並びに性質解析2017
- Author(s)
  太田雅士、石井和貴、田良島典子、南川典昭
- Organizer
  第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] 核酸分子の簡便精製を可能とする‘キャッチ&リリース’タグの開発2017
- Author(s)
  井形陽佑、相良和幸、田良島典子、南川典昭
- Organizer
  日本ケミカルバイオロジー学会第12回年会
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] 化学修飾DNAを利用したRNA創薬2017
- Author(s)
  南川典昭、田良島典子、高橋知樹、山本清義、金城望、安藤英紀、石田竜弘、小暮健太朗
- Organizer
  第33回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] 機能性核酸合成を志向した化学的核酸連結反応2017
- Author(s)
  笈川涼太、早川真由、丸山豪斗、阿部奈保子、木村康明、周東智、松田彰、南川典昭、阿部洋
- Organizer
  日本核酸医薬学会第３回年会
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] 微弱電流処理を利用した機能性核酸の細胞内取り込みの検討2017
- Author(s)
  大島康史、Mahadi Hasan、田良島典子、濱　進、福田達也、田中　保、南川典昭、小暮健太朗
- Organizer
  日本薬学会138年会
- Data Source
  KAKENHI-PROJECT-17H03976
[Presentation] ユニークなエンドサイトーシスを誘起する微弱電流を利用した機能性核酸の細胞質送達2017
- Author(s)
  大島康史、虎尾　祐、三村美夕紀、Mahadi Hasan、田良島典子、濱　進、福田達也、田中　保、南川典昭、小暮健太朗
- Organizer
  第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] Chemical and enzymatic syntheses of 4’-selenonucleic acids2017
- Author(s)
  Noriaki Minakawa
- Organizer
  FIBER International Summit for Nucleic Acids 2017
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] 微弱電流処理による高分子医薬の細胞質送達と機能発現2017
- Author(s)
  小暮健太朗、大島康史、虎尾　祐、三村美夕紀、藤川昂樹、Mahadi Hasan、濱　進、福田達也、田良島典子、田中　保、南川典昭
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17H03976
[Presentation] 塩基改変したU1 snRNAによるカテプシンAスプライス異常修復効果の検討2016
- Author(s)
  木村麻里安, 池啓伸, 斎藤朱里, 山﨑尚志, 伊藤孝司, 南川典昭, 滝口祥令
- Organizer
  第57回日本生化学会中国四国支部例会
- Place of Presentation
  高知大学（高知県・南国市）
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-16K08235
[Presentation] RNA-タンパク質間相互作用解析のためのケミカルアプローチ2016
- Author(s)
  南川典昭
- Organizer
  日本核酸医薬学会第2回年会
- Place of Presentation
  東京理科大学葛飾キャンパス（東京都葛飾区）
- Year and Date
  2016-11-15
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] Development of RNAi medicine using chemically-modified DNA analogs2016
- Author(s)
  Noriaki Minakawa
- Organizer
  FIBER International Summit for Nucleic Acids 2016
- Place of Presentation
  甲南大学（兵庫県神戸市）
- Year and Date
  2016-07-06
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] ‘キャッチ&リリース’ 法を用いたオリゴヌクレオチドの簡便精製法の開発2016
- Author(s)
  井形陽佑、相良和幸、田良島典子、南川典昭
- Organizer
  日本核酸医薬学会第2回年会
- Place of Presentation
  東京理科大学葛飾キャンパス（東京都葛飾区）
- Year and Date
  2016-11-15
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] カテプシンAスプライシング異常の修復を目指した改変U1 snRNA発現系の構築2016
- Author(s)
  木村麻里安, 四宮槙子, 池啓伸, 齋藤朱里, 山﨑尚志, 伊藤孝司, 南川典昭, 滝口祥令
- Organizer
  第55回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大
- Place of Presentation
  就実大学（岡山県・岡山市）
- Year and Date
  2016-11-06
- Data Source
  KAKENHI-PROJECT-16K08235
[Presentation] Rescue of mutation-induced exon 7 skipping in human Cathepsin A by using modified U1 small nuclear RNA2016
- Author(s)
  Naoshi Yamazaki, Yasuo Shinohara, Kohji Itoh, Noriaki Minakawa and Yoshiharu Takiguchi
- Organizer
  2016 ASCB Annual Meeting
- Place of Presentation
  San Francisco（USA）
- Year and Date
  2016-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08235
[Presentation] Chemical and enzymatic synthesis of 4’-seleno oligonucleotides.2016
- Author(s)
  Noriko Tarashima, Koya Hayashi, Takuya Sumitomo, Noriaki Minakawa
- Organizer
  The 44th International Symposium on Nucleic Acids Chemistry (ISNAC 2016)
- Place of Presentation
  熊本大学（熊本県熊本市）
- Year and Date
  2016-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] Development of a Minimally-Sized DNA Vector for Gene Silencing using an Unnatural Base Pair Analog Having Four Hydrogen Bonds2015
- Author(s)
  Noriko Tarashima, Noriaki Minakawa
- Organizer
  AIMECS 2015(10th AFMC International Medicinal Chemistry Symposium in 2015)
- Place of Presentation
  International Convention Center(ICC),JEJU(Korea)
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] Gene silencing via RNA interference (RNAi) machinery using 4'-thioDNA as an artificial template2015
- Author(s)
  Noriko Tarashima, Nozomi Kinjyo, Takamitsu Kojima, Hidenori Ando,Tatsuhiro Ishida, Noriaki Minakawa
- Organizer
  The 42nd International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  I-messae hall（Himeji,Japan ）
- Year and Date
  2015-09-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] A New Approach For Gene Silencing Using 4’-ThioDNA2015
- Author(s)
  Noriaki Minakawa
- Organizer
  AIMECS 2015(10th AFMC International Medicinal Chemistry Symposium in 2015)
- Place of Presentation
  International Convention Center(ICC),JEJU(Korea)
- Year and Date
  2015-10-18
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] 4’-チオDNAを用いた遺伝子発現抑制の新戦略2015
- Author(s)
  南川　典昭
- Organizer
  BMB2015(Biochemistry and Molecular Biology)
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] Development of RNAi Medicine Using4'-ThioDNA2015
- Author(s)
  Noriaki Minakawa
- Organizer
  The 4th International Conference on Biotechnology and Bioengineering
- Place of Presentation
  Peninsula Excelsior Hotel (Singapore)
- Year and Date
  2015-12-12
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] 人工塩基対の酵素認識に基づくダンベル型遺伝子発現デバイスの創製2015
- Author(s)
  田良島　典子、南川　典昭
- Organizer
  日本核酸医薬学会第1回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] A New Approach For Gene Silencing Using 4’-ThioDNA2015
- Author(s)
  N. Minakawa
- Organizer
  10th AFMC International Medicinal Chemistry Symposium (AIMECS2015)
- Place of Presentation
  ICC Jeju (Jeju, Korea)
- Year and Date
  2015-10-18
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PUBLICLY-26107713
[Presentation] Development of RNAi Medicine Using 4’-ThioDNA2015
- Author(s)
  N. Minakawa
- Organizer
  The 4th International Conference on Biotechnology and Bioengineering (ICBB2015)
- Place of Presentation
  Peninsula Excelsior Hotel (Singapore, Singapore)
- Year and Date
  2015-12-12
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PUBLICLY-26107713
[Presentation] 人工塩基対を利用した第2世代intelligent RNA expression device (iRed) の開発研究2015
- Author(s)
  田良島典子、南川典昭
- Organizer
  遺伝子・デリバリー研究会第15回シンポジウム
- Place of Presentation
  京都薬科大学（京都府京都市）
- Year and Date
  2015-05-01
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] 化学修飾DNAを利用したRNAi創薬2015
- Author(s)
  南川　典昭
- Organizer
  核酸化学最前線フォーラム
- Place of Presentation
  甲南大学(兵庫県神戸市)
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-15H04656
[Presentation] 人工塩基対ImNN:NaOOのPCR増幅とRNAi創薬への応用2014
- Author(s)
  南川典昭
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本大学（熊本県）
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] 新規1, 2-ジチアンヌクレオシドの合成と性質2013
- Author(s)
  南川典昭
- Organizer
  第５２回日本薬学会中国四国支部学術大会
- Place of Presentation
  松山大学（愛媛県）
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] ケミカルツールを用いたsiRNA-タンパク質間の相互作用様式解明2013
- Author(s)
  南川典昭
- Organizer
  日本薬学会第１３３年会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PUBLICLY-24107518
[Presentation] A novel approach of gene suppression using an intelligent shRNA expressing device (iRed)2013
- Author(s)
  Noriaki Minakawa
- Organizer
  9th Annual Meeting of the Oligonucleotide Therapeutics Society
- Place of Presentation
  Royal Continental Hotel (Italy)
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] 改変U1 snRNAによる遺伝子発現抑制効果の検討2013
- Author(s)
  南川典昭
- Organizer
  第２３回アンチセンスシンポジウム
- Place of Presentation
  徳島大学（徳島県）
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] 新規Im : Na塩基対のDNAポリメラーゼによる基質認識2013
- Author(s)
  南川典昭
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] Enzymatic incorporation of unnatural ImNN:NaOO base pair consisting of four hydrogen bonds2013
- Author(s)
  南川典昭
- Organizer
  第４０回国際核酸化学シンポジウム
- Place of Presentation
  神奈川大学（神奈川県）
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] 化学修飾DNAを利用するRNAi創薬の新展開2012
- Author(s)
  南川典昭
- Organizer
  第19回ファーマサイエンスフォーラム
- Place of Presentation
  北海道大学(北海道)(招待講演)
- Year and Date
  2012-07-25
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] Gene silencing by 2' -modified-4' -thio oligonucleotides via U1i machinery2012
- Author(s)
  Noriaki Minakawa
- Organizer
  第39回国際核酸化学シンポジウム
- Place of Presentation
  名古屋大学(愛知県)
- Year and Date
  2012-11-15
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] 2'-F-4'-チオヌクレオシドを含むキメラ型オリゴマーの合成と性質2012
- Author(s)
  菊地優作、山崎尚志、滝口祥令、南川典昭
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学、札幌市
- Data Source
  KAKENHI-PROJECT-23659054
[Presentation] ケミカルツールを利用したRNA干渉の発現機構解明2012
- Author(s)
  南川典昭
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2012
- Place of Presentation
  仙台市民会館（宮城県）
- Year and Date
  2012-09-24
- Data Source
  KAKENHI-PUBLICLY-24107518
[Presentation] Gene silencing by 2'-modified-4'-thio oligonucleotides via U1i machinery2012
- Author(s)
  Yusaku Kikuchi, Naoshi Yamazaki, Yoshiharu Takiguchi, Noriaki Minakawa
- Organizer
  第39回国際核酸化学シンポジウム
- Place of Presentation
  名古屋大学豊田講堂、名古屋市
- Data Source
  KAKENHI-PROJECT-23659054
[Presentation] Chemistry & Biology of 4'-thioDNA2012
- Author(s)
  Noriaki Minakawa
- Organizer
  Memorial Seminar of International Academic Exchange between Dongguk University & The University of Tokushima
- Place of Presentation
  Dongguk University (Korea)(招待講演)
- Year and Date
  2012-12-21
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] Gene silencing by 2'-modified-4'-thio oligonucleotides via U1i machinery2012
- Author(s)
  南川典昭
- Organizer
  第３９回国際核酸化学シンポジウム
- Place of Presentation
  名古屋大学豊田講堂（愛知県）
- Data Source
  KAKENHI-PROJECT-23659054
[Presentation] 改変U1snRNAによる遺伝子発現抑制2012
- Author(s)
  南川典昭
- Organizer
  日本薬学会中国四国支部学術大会
- Place of Presentation
  島根県民会館（島根県）
- Data Source
  KAKENHI-PROJECT-23659054
[Presentation] Huisgen反応を利用したImO^N : NaN^o塩基対を含む環状DNAの合成研究2012
- Author(s)
  南川典昭
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2012
- Place of Presentation
  仙台市民会館(宮城県)
- Year and Date
  2012-09-25
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] 4'-チオDNAを利用した新規RNAi法の開発2012
- Author(s)
  南川典昭
- Organizer
  第6回バイオ関連化学シンポジウム
- Place of Presentation
  北海道大学(北海道)
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] 核酸医薬の現状と将来2012
- Author(s)
  南川典昭
- Organizer
  プロセス化学東四国フォーラムセミナー
- Place of Presentation
  徳島文理大学(徳島県)(招待講演)
- Year and Date
  2012-09-29
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] 2'-O-Me-4'-thioRNA as a Potential Use for Oligonucleotide Therapeutics2012
- Author(s)
  A. Matsuda, M. Takahashi, N. Minakawa, H. Hatakeyama, M. Murata, Y. Sato, H. Harashima
- Organizer
  8th Annual Meeting of the Oligonucleotide Therapeutic Society
- Place of Presentation
  The conference center at Harvard Medical School, Boston, USA
- Data Source
  KAKENHI-PROJECT-23659054
[Presentation] Synthesis of 4'-selenoribonucleosides using hypervalent iodine2010
- Author(s)
  H.Taniike, Y.Inagaki, A.Matsuda, N.Minakawa
- Organizer
  2010環太平洋国際化学会議PACIFICHEM2010
- Place of Presentation
  ホノルル
- Data Source
  KAKENHI-PROJECT-20611001
[Presentation] Evaluation of potency and duration of gene silencing activity by siRNAs containing hybrid type of chemically modified nucleotides2010
- Author(s)
  M.Takahashi, C.Nagai, H.Hatakeyama, N.Minakawa, H.Harashima, A.Matsuda
- Organizer
  International Round Table
- Place of Presentation
  France
- Data Source
  KAKENHI-PROJECT-20611001
[Presentation] Convenient RNA synthesis using a phosphoramidite possessing a photocleavable group2010
- Author(s)
  N.Minakawa
- Organizer
  日韓合同シンポジウム
- Place of Presentation
  淡路市
- Year and Date
  2010-12-22
- Data Source
  KAKENHI-PROJECT-20611001
[Presentation] Unnatural imidazopyridopyrimidine : naphthyridine base pairs : selective incorporation and extension reaction by DNA polymerase.2009
- Author(s)
  N.Minakawa, S.Ogata, M.Takahashi, A.Matsuda
- Organizer
  The 6^<th> International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Takayama Gifu
- Data Source
  KAKENHI-PROJECT-20611001
[Presentation] Unnatural imidazopyridopyrimidine : naphthyridine base pairs : selective incorporation and extension reaction by DNA polymerase2009
- Author(s)
  N.Minakawa, et al.
- Organizer
  The 6^<th> International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Takayama, Gifu
- Year and Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-20611001
[Presentation] Development od Chemical Probes to Investigate the Molecular Mechanism of RNAi2009
- Author(s)
  S.Ide, N.Minakawa, A.Matsuda
- Organizer
  国際核酸医薬シンポジウム
- Place of Presentation
  Fukuoka
- Data Source
  KAKENHI-PROJECT-20611001
[Presentation] Synthesis and properties of 2'-modified-4'-thioRNA.2008
- Author(s)
  M.Takahashi, N.Minakawa, A.Matsuda
- Organizer
  Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35^<th> International Symposium on Nucleic Acids Chemistry.
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20611001
[Presentation] 核酸化学からアプタマーへ : ヌクレアーゼ抵抗性の化学的調節2008
- Author(s)
  松田彰、加藤優佳、三次未央子、高橋真由美、南川典昭
- Organizer
  第18回日本サイトメトリー学会「サイトメトリーシステムの未来を考える(1)アプタマーは抗体を越えるのか?
- Place of Presentation
  東京慈恵医科大学
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-18109001
[Presentation] Synthesis and properties of oligonucleotides containing 4'-selenoribonucleosides.2008
- Author(s)
  Y.Inagaki, N.Minakawa, A.Matsuda
- Organizer
  Joint Symposium of the 18^<th> International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35^<th> International Symposium on Nucleic Acids Chemistry.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20611001
[Presentation] Amplification of 4'-thioDNA and its utility as a siRNA expression.2007
- Author(s)
  南川典昭
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京大学安田講堂
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-18109001
[Presentation] Amplification of 4'-thioDNA and its utility as a shRNA expression system2007
- Author(s)
  N. Minakawa, ら
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京大学安田講堂
- Year and Date
  2007-11-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18510180
[Presentation] Synthesis of bromodeazaadenine nucleosides and their Properties2006
- Author(s)
  Y. Kawano, S. Murata, N. Inoue, N. Minakawa, A. Matsuda
- Organizer
  The 126^<th> Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  (Sendai)
- Year and Date
  2006-03-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510180
[Presentation] A new dumbbell-shaped decoy DNA targeting NF-kB with the unnatural base pair ImON:NaNO
- Author(s)
  Kazuhiro Furukawa, Yosuke Higuchi, Tadashi Miyazawa, Noriaki Minakawa
- Organizer
  10th Annual meeting of the oligonucleotide therapeutics society
- Place of Presentation
  San Diego (USA)
- Year and Date
  2014-10-12 – 2014-10-15
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] Enzymatic synthesis of 4’-selenoDNA
- Author(s)
  Noriko Tarashima, Tatsuya Sumitomo, Kazuhiro Furukawa, Noriaki Minakawa
- Organizer
  XXI Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Poznan(Poland)
- Year and Date
  2014-08-24 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] Synthesis and properties of a novel 1,2-dithianenucleoside
- Author(s)
  Tadashi Miyazawa, Noriko Tarashima, Kazuhiro Furukawa, Noriaki Minakawa
- Organizer
  第４１回国際核酸化学シンポジウム
- Place of Presentation
  北九州国際会議場（福岡県北九州市）
- Year and Date
  2014-11-05 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-26630432
[Presentation] Intelligent RNA expressing device (iRed) を利用した核酸創薬の新手法
- Author(s)
  田良島典子，小島孝光，金城望，古川和寛、安藤英紀，石田竜弘，南川典昭
- Organizer
  第３２回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] ハイブリッド型化学修飾核酸2’-O-MOE-4’-thioRNAの合成とアンチmiRNAとしてのin vitro/vivo機能評価
- Author(s)
  田良島典子，齋藤陽太，橋本洋佑，古川和寛，石田竜弘，南川典昭
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2014
- Place of Presentation
  東京医科歯科大学（東京都文京区）
- Year and Date
  2014-09-08 – 2014-09-09
- Data Source
  KAKENHI-PUBLICLY-26107713
[Presentation] 4’-セレノ核酸の化学 ―4’-セレノ核酸は4’-チオ核酸を超えることが出来るか？―
- Author(s)
  南川典昭
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム２０１４
- Place of Presentation
  東京医科歯科大学（東京都文京区）
- Year and Date
  2014-09-08 – 2014-09-09
- Invited
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] Intelligent RNA expression device (iRed) を利用した新規遺伝子発現抑制法の開発
- Author(s)
  田良島典子, 小島孝允, 金城望, 古川和寛, 安藤　英紀, 石田竜弘, 南川典昭
- Organizer
  第９５回日本化学会
- Place of Presentation
  日本大学　船橋キャンパス（千葉県船橋市）
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24390027
[Presentation] ナノ核酸デバイスを利用したsiRNA-タンパク質相互作用における分子認識機構の解明
- Author(s)
  田良島典子、吉良太孝、山﨑尚志、古川和寛、南川典昭
- Organizer
  創薬懇話会2014
- Place of Presentation
  長良川温泉パークホテル（岐阜県岐阜市）
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PUBLICLY-26107713
[Presentation] Gene silencing via RNAi machinery using 4’-thioDNA
- Author(s)
  Noriaki Minakawa
- Organizer
  The 6th Taiwan-Japan Symposium on Nanomedicine
- Place of Presentation
  Academia Sinica (Taipei Taiwan)
- Year and Date
  2015-01-08 – 2015-01-09
- Data Source
  KAKENHI-PUBLICLY-26107713
[Presentation] HOW TO PREPARE 4’-SELENORNA?
- Author(s)
  Noriaki Minakawa, Noriko Tarashima, Koya Hayashi, Maki Terasaki, Hirotsugu Taniike, Yusuke Inagaki, Shinji Fukuda, Kazuhiro Furukawa and Akira Matsuda
- Organizer
  XXI Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Poznan(Poland)
- Year and Date
  2014-08-24 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-24390027

1. MATSUDA Akira (90157313)

# of Collaborated Projects: 9 results

# of Collaborated Products: 22 results
2. 小暮健太朗 (70262540)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
3. ISHIDA Tstsuhiro (50325271)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. 上田亨 (00001032)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. Ono Akira (10183253)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ITOH Koji (00184656)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. YAMAZAKI Naoshi (20271083)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. 田良島典子 (90755183)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. HARASHIMA Hideyoshi (00183567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KONDO Jiro (10546576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SANEYOSHI Hisao (10564784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TANAKA Yoshiyuki (70333797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. URATA Hidehito (80211085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TORIGOE Hidetake (80227678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Komatsu Yasuo (30271670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. FURUKAWA Kazuhiro (00644999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. IWATA Takeo (10350399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 周東智 (70241346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 秋田英万 (80344472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 谷知己 (80332378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 岡本到 (40460133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 平野悠 (70415735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 異島優 (00457590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 清水太郎 (30749388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 安藤英紀 (00735524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 鵜川真実 (50735511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 阿部洋 (80415067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. 田中保 (90258301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
29. 山本清義 (80783521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 水澤典子 (80254746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
31. 吉本勝彦 (90201863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
32. SATO Kosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. SATO Yusuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 紙谷浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 畠山浩人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 斎藤博幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Minakawa Noriaki 南川 典昭

MINAKAWA Noriaki 南川 典昭

南川 典昭 ミナカワ ノリアキ

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「食べるマイクロRNAを創る」 ー機能性食品としての核酸ーPrincipal InvestigatorOngoing

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iRedによる核酸創薬研究を加速させる外部刺激応答型核酸ナノ構造体の創製Principal InvestigatorOngoing

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微弱電流によるナノ粒子の腫瘍内浸透・細胞取込み亢進による革新的がん治療技術の確立Ongoing

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高いスプライス異常修復能を有した改変U1 snRNA発現ベクターの構築と疾病治療Ongoing

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Study of immunological response to nucleic acid delivery system

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Investigation of practical anticancer strategy based on chemically synthesized iRed/iPedPrincipal Investigator

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Mechanisms of adipose tissue-specific expression and action of D-dopachrome tautomrase

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ナノ核酸デバイスを用いた自然免疫応答発現機構の網羅的解析Principal Investigator

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Development of DDS system based on the intracellular enviroment responsive aptamersPrincipal Investigator

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Development of anti-miRNA oligonucleotides with stable duplexes to control cardiac diseases.

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ケミカルデバイスを利用したｓｉＲＮＡによって誘起される分子反応の発現機構解明Principal Investigator

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Development of DNA based heavy metal ions removing membranes and nanowires-structures, properties, applications.

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Development of a novel RNAi medicine based on shRNA expression mini-plasmidPrincipal Investigator

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Minakawa Noriaki 南川典昭

MINAKAWA Noriaki 南川典昭

南川典昭ミナカワノリアキ

「食べるマイクロRNAを創る」　ー機能性食品としての核酸ーPrincipal InvestigatorOngoing