KUWASAKO KANAKO 桑迫香奈子

… Alternative Names

Kuwasako Kanako 桑迫香奈子

NAMEKI Kanako 行木香奈子

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Researcher Number	10568736
Other IDs
Affiliation (Current)	2025: 武蔵野大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2018 – 2023: 武蔵野大学, 薬学部, 講師 2015 – 2017: 武蔵野大学, 薬学研究所, 講師 2015: 武蔵野大学, 薬学部薬学科, 講師
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Structural biochemistry Except Principal Investigator Basic Section 38030:Applied biochemistry-related / Living organism molecular science
Keywords	Principal Investigator mRNAスプライシング / pre-mRNAスプライシング / RNAアプタマー / U2 snRNP / 構造生物学 / 結晶化 / SELEX / NMR / がん / スプライシング … More Except Principal Investigator … More 構造生物学 / 協働性 / スプライシング病 / スプライシング制御因子 / Presenilin-2 / 癌 / アルツハイマー病 / Presenillin-2 / HMGA1 / スプライシング / 遺伝子発現 Less

RNAアプタマーを利用したU2 snRNPの「ゆるい」ブランチ部位認識機構の解明Principal Investigator
- Principal Investigator
  
  桑迫香奈子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Musashino University
脊髄性筋萎縮症に関わるスプライシング制御因子の協同作用の解明
- Principal Investigator
  
  武藤裕
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Musashino University
Structural basis for the sequence-specific RNA-recognition mechanism of a human splicing regulatory proteinPrincipal Investigator
- Principal Investigator
  
  Kuwasako Kanako
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Musashino University
Structural study of human spliceosomal protein SF3b1Principal Investigator
- Principal Investigator
  
  Kuwasako Kanako
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Musashino University
Global disorder of splicing caused by oncogene product HMGA1
- Principal Investigator
  
  MAYEDA Akila
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Fujita Health University

All 2023 2022 2021 2018 2017 2016 2015 2013

All Journal Article Presentation

[Journal Article] Structural insights into recognition of SL4, the UUCG stem-loop, of human U1 snRNA by the ubiquitin-like domain, including the C-terminal tail in the SF3A1 subunit of U2 snRNP2023
- Author(s)
  Nameki Nobukazu、Terawaki Shin-ichi、Takizawa Masayuki、Kitamura Madoka、Muto Yutaka、Kuwasako Kanako
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 174 Issue: 2 Pages: 203-216
- DOI
  10.1093/jb/mvad033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06105, KAKENHI-PROJECT-23K05677
[Journal Article] 1H, 13C, and 15N resonance assignments and solution structures of the KH domain of human ribosome binding factor A, mtRbfA, involved in mitochondrial ribosome biogenesis.2022
- Author(s)
  Kuwasako K, Suzuki S, Nameki N, Takizawa M, Takahashi M, Tsuda K, Nagata T, Watanabe S, Tanaka A, Kobayashi N, Kigawa T, Guntert P, Shirouzu M, Yokoyama S, Muto Y
- Journal Title
  
  Biomol NMR Assign.
  
  Volume: 16 Issue: 2 Pages: 297-303
- DOI
  10.1007/s12104-022-10094-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05397, KAKENHI-PROJECT-20K06508
[Journal Article] 1 H, 13 C and 15 N resonance assignments and solution structures of the two RRM domains of Matrin-32021
- Author(s)
  He F, Kuwasako K, Takizawa M, Takahashi M, Tsuda K, Nagata T, Watanabe S, Tanaka A, Kobayashi N, Kigawa T, Guntert P, Shirouzu M, Yokoyama S, Muto Y.
- Journal Title
  
  Biomol NMR Assign.
  
  Volume: Nov16 Issue: 1 Pages: 41-49
- DOI
  10.1007/s12104-021-10057-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05397, KAKENHI-PROJECT-20K06508
[Journal Article] Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment2017
- Author(s)
  Kuwasako, K.
- Journal Title
  
  Protein Science
  
  Volume: 26 Issue: 2 Pages: 280-290
- DOI
  10.1002/pro.3080
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01548, KAKENHI-PROJECT-16H04756, KAKENHI-PROJECT-15K06945, KAKENHI-PROJECT-15K06970, KAKENHI-PROJECT-15K06982, KAKENHI-PROJECT-17K07312
[Journal Article] A novel 3' splice site recognition by the two zinc fingers in the U2AF small subunit.2015
- Author(s)
  Yoshida H, Park S-Y, Oda T, Akiyoshi T, Sato M, Shirouzu M, Tsuda K, Kuwasako K, Unzai S, Muto Y, Urano T, Obayashi E.
- Journal Title
  
  Genes Dev.
  
  Volume: 29 Issue: 15 Pages: 1649-1660
- DOI
  10.1101/gad.267104.115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06980, KAKENHI-PROJECT-15K06982, KAKENHI-PROJECT-15K18499, KAKENHI-PUBLICLY-26116519, KAKENHI-PROJECT-25291016, KAKENHI-PROJECT-25291037
[Journal Article] Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes.2015
- Author(s)
  Suzuki M, Sasabe J, Miyoshi Y, Kuwasako K, Muto Y, Hamase K, Matsuoka M, Imanishi N, Aiso S.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 112 Issue: 17
- DOI
  10.1073/pnas.1416117112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06982, KAKENHI-PROJECT-15H04689
[Presentation] X-ray crystallography of the ubiquitin-like domain in the SF3A1 subunit of human U2 snRNP complexed with SL4, the UUCG stem-loop, of U1 snRNA.2023
- Author(s)
  Terawaki S, Nameki N, Takizawa M, Kitamura M, Muto Y, Kuwasako K.
- Organizer
  The 21st Protein Island Matsuyama International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06105
[Presentation] ヒトU2 snRNPのサブユニットSF3A1のubiquitin-likeドメインと U1 snRNAのstem-loop4構造との複合体のX線結晶構造解析2023
- Author(s)
  寺脇慎一、行木信一、瀧澤将行、北村まどか、武藤裕、桑迫香奈子
- Organizer
  第96回日本生化学大会
- Data Source
  KAKENHI-PROJECT-22K06105
[Presentation] ヒトU2 snRNPの構成因子SF3A1のN末端側に存在するSURPドメインとスプライシング因子SF1との相互作用メカニズムの解明2023
- Author(s)
  行木信一、瀧澤将行、鈴木章元、谷昌子、小林直宏、坂本泰一、武藤裕、桑迫香奈子
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06105
[Presentation] スプライシング因子の複合体に結合するaptamerの結合能の解析2018
- Author(s)
  佐藤謙太郎，柳澤拓也，瀧澤将行，天野亮，武藤裕，桑迫香奈子，坂本泰一
- Organizer
  2018年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-15K06982
[Presentation] スプライシング因子の複合体に結合するaptamerの特性解析2018
- Author(s)
  佐藤謙太郎，柳澤拓也，瀧澤将行，天野亮，武藤裕，桑迫香奈子，坂本泰一
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K06982
[Presentation] Selection of RNA sequences that bind to a complex of splicing factors.2017
- Author(s)
  柳澤拓也，桑迫香奈子，天野亮，瀧澤将行，武藤裕，坂本泰一
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K06982
[Presentation] スプライシング因子の複合体に対するaptamerの取得と解析2017
- Author(s)
  柳澤拓也，桑迫香奈子，徳田正明，天野亮，武藤裕，坂本泰一
- Organizer
  平成29年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-15K06982
[Presentation] In vitro selection of RNA aptamers to a splicing factor.2016
- Author(s)
  Takuya Yanagisawa, Kanako Kuwasako, Ryo Amano, Yutaka Muto, Taiichi Sakamoto
- Organizer
  18th Annual Meeting (21st Annual Meeting of the RNA Society)
- Place of Presentation
  Kyoto International Conference Center
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06982
[Presentation] Solution structures of the two RNA recognition motif (RRM) domains of the human spliceosomal protein SF3b49.2016
- Author(s)
  Kanako Kuwasako, Kengo Tsuda, Mari Takahashi, Atsuko Sato, Naoya Tochio, Makoto Inoue, Takaho Terada, Takanori Kigawa, Naohiro Kobayashi, Mikako Shirouzu, Takuhiro Ito, Taiichi Sakamoto, Nobukazu Nameki, Kaori Wakamatsu, Peter Guntert, Seizo Takahashi, Shigeyuki Yokoyama, Yutaka Muto
- Organizer
  18th Annual Meeting (21st Annual Meeting of the RNA Society)
- Place of Presentation
  Kyoto International Conference Center
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06982
[Presentation] Sequence-specific RNA-binding of HMGA1a may play a role in acquired resistance of estrogen receptor-positive breast carcinoma2013
- Author(s)
  Ohe K, Miyajima S, Kuwasako K, Muto Y, Utsumi T, Hagiwara M, Mayeda A
- Organizer
  Eukaryotic mRNA Processing Meeting
- Place of Presentation
  Cold Spring Harbor Laboratory, USA
- Data Source
  KAKENHI-PROJECT-24310161

1. MUTOH Yutaka (30192769)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 坂本泰一 (40383369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. MAYEDA Akila (50212204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. KATAYAMA Tai-ichi (80333459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OHE Kenji (30419527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 吉村明 (70302164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 井上裕介 (90304302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 朴三用

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 雲財悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUWASAKO KANAKO 桑迫 香奈子

Kuwasako Kanako 桑迫 香奈子

NAMEKI Kanako 行木 香奈子

Research Projects

Research Products

Co-Researchers

RNAアプタマーを利用したU2 snRNPの「ゆるい」ブランチ部位認識機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脊髄性筋萎縮症に関わるスプライシング制御因子の協同作用の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural basis for the sequence-specific RNA-recognition mechanism of a human splicing regulatory proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural study of human spliceosomal protein SF3b1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Global disorder of splicing caused by oncogene product HMGA1

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structural insights into recognition of SL4, the UUCG stem-loop, of human U1 snRNA by the ubiquitin-like domain, including the C-terminal tail in the SF3A1 subunit of U2 snRNP2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 1H, 13C, and 15N resonance assignments and solution structures of the KH domain of human ribosome binding factor A, mtRbfA, involved in mitochondrial ribosome biogenesis.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 1 H, 13 C and 15 N resonance assignments and solution structures of the two RRM domains of Matrin-32021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel 3' splice site recognition by the two zinc fingers in the U2AF small subunit.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] X-ray crystallography of the ubiquitin-like domain in the SF3A1 subunit of human U2 snRNP complexed with SL4, the UUCG stem-loop, of U1 snRNA.2023

Author(s)

Organizer

Data Source

[Presentation] ヒトU2 snRNPのサブユニットSF3A1のubiquitin-likeドメインと U1 snRNAのstem-loop4構造との複合体のX線結晶構造解析2023

Author(s)

Organizer

Data Source

[Presentation] ヒトU2 snRNPの構成因子SF3A1のN末端側に存在するSURPドメインとスプライシング因子SF1との相互作用メカニズムの解明2023

Author(s)

Organizer

Data Source

[Presentation] スプライシング因子の複合体に結合するaptamerの結合能の解析2018

Author(s)

KUWASAKO KANAKO 桑迫香奈子

Kuwasako Kanako 桑迫香奈子

NAMEKI Kanako 行木香奈子