Takeshita Masaru 竹下勝

… Alternative Names

TAKESHITA Masaru 竹下勝

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Researcher Number	10571135
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 慶應義塾大学, 医学部(信濃町), 講師 2021: 慶應義塾大学, 医学部(信濃町), 助教 2016 – 2020: 慶應義塾大学, 医学部(信濃町), 特任助教 2017: 慶應義塾大学, 医学部(信濃町), 助教 2016: 慶應義塾大学, 医学部リウマチ内科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology Except Principal Investigator Collagenous pathology/Allergology / Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator 自己免疫疾患 / 自己抗体 / シェーグレン症候群 / 関節リウマチ / B細胞 / 唾液腺 / 肺胞洗浄液 / 抗ARS抗体症候群 / モノクローナル抗体 / シングルセル解析 … More / 液性免疫 / 抗原特異性 / 混合性結合組織病 / 免疫学 / リウマチ因子 / 抗体 / HLA / 抗原提示 / 自己免疫 … More Except Principal Investigator 自己免疫疾患 / 自己抗体 / シェーグレン症候群 / 関節リウマチ / 腸内細菌 / マクロファージ / 炎症性腸疾患 / 残存分子シグネチャー / 診断前継時コホート / 寛解、分子病態、網羅的解析 / リウマチ因子 / 肺胞洗浄液 / 抗翻訳後修飾蛋白抗体 / 抗シトルリン化タンパク質抗体 / 抗原特異性 / リンパ球 / 間質性肺炎 / シングルセル解析 / レパトア解析 / 全身性強皮症 / 自己抗原 / 抗セントロメア抗体 / B細胞 / 自己免疫 / リウマチ内科学 / 膠原病・アレルギー内科学 / 分泌型キナーゼ / キナーゼ / FAM20A Less

Comprehensive Understanding of Host Immune-Gut Microbiota Interactions underlying Autoimmune Diseases
- Principal Investigator
  
  三上洋平
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Keio University
自己免疫疾患の病変部位における自己抗体の産生機構の解明Principal Investigator
- Principal Investigator
  
  竹下勝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Keio University
Single cell integrated analysis of antigen specificity and gene expression for the cure of autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  Masaru Takeshita
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Keio University
Molecular signatures in pre-RA patients by multi-omics analysis
- Principal Investigator
  
  TAKEUCHI Tsutomu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Keio University
Multiomics analysis of auto reactive immune cells in the inflammatory sites in autoimmune diseases.
- Principal Investigator
  
  Takeuchi Tsutomu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Keio University
Novel antigen presentation mechanism in autoimmune diseases and its significancePrincipal Investigator
- Principal Investigator
  
  Masaru Takeshita
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Keio University
Investigation of regulatory mechanism of secretary protein kinase and its application for treatment of rheumatoid arthritis
- Principal Investigator
  
  Takeuchi Tsutomu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Immune evasion and chronological decrease in titer of neutralizing antibody against SARS-CoV-2 and its variants of concerns in COVID-19 patients2022
- Author(s)
  Takeshita Masaru、Nishina Naoshi、Moriyama Saya、Takahashi Yoshimasa、Ishii Makoto、Saya Hideyuki、Kondo Yasushi、Kaneko Yuko、Suzuki Katsuya、Fukunaga Koichi、Takeuchi Tsutomu
- Journal Title
  
  Clinical Immunology
  
  Volume: 238 Pages: 108999-108999
- DOI
  10.1016/j.clim.2022.108999
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17450, KAKENHI-PROJECT-20H03720
[Journal Article] Nation-wide cohort study of remission induction therapy using rituximab in Japanese patients with antineutrophil cytoplasmic antibody associated vasculitis: Effectiveness and safety in the first 6 months2022
- Author(s)
  Nagasaka Kenji、Amano Koichi、Dobashi Hiroaki、Nagafuchi Hiroko、Sada Ken-Ei、Komagata Yoshinori、Yamamura Masahiro、Kato Masaru、Endo Tomomi、Nakaya Izaya、Takeuchi Tsutomu、et al.
- Journal Title
  
  Modern Rheumatology
  
  Volume: ー Issue: 6 Pages: 1117-1124
- DOI
  10.1093/mr/roac150
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03720
[Journal Article] Distinct Expression of Coinhibitory Molecules on Alveolar T Cells in Patients With Rheumatoid Arthritis Associated and Idiopathic Inflammatory Myopathy Associated Interstitial Lung Disease2021
- Author(s)
  Nakazawa Maho、Suzuki Katsuya、Takeshita Masaru、Inamo Jun、Kamata Hirofumi、Ishii Makoto、Oyamada Yoshitaka、Oshima Hisaji、Takeuchi Tsutomu
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: 73 Issue: 4 Pages: 576-586
- DOI
  10.1002/art.41554
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17430, KAKENHI-PROJECT-20H03720
[Journal Article] Antigen-driven autoantibody production in lungs of interstitial lung disease with autoimmune disease2021
- Author(s)
  Takeshita Masaru、Suzuki Katsuya、Nakazawa Maho、Kamata Hirofumi、Ishii Makoto、Oyamada Yoshitaka、Oshima Hisaji、Takeuchi Tsutomu
- Journal Title
  
  Journal of Autoimmunity
  
  Volume: 121 Pages: 102661-102661
- DOI
  10.1016/j.jaut.2021.102661
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17430, KAKENHI-PROJECT-20H03720
[Journal Article] Anti-centromere antibodies target centromere kinetochore macrocomplex: a comprehensive autoantigen profiling2020
- Author(s)
  Kajio Nobuhiko、Takeshita Masaru、Suzuki Katsuya、Kaneda Yukari、Yamane Humitsugu、Ikeura Kazuhiro、Sato Hidekazu、Kato Shin、Shimizu Hiroyuki、Tsunoda Kazuyuki、Takeuchi Tsutomu
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: 80 Issue: 5 Pages: 651-659
- DOI
  10.1136/annrheumdis-2020-218881
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17430, KAKENHI-PROJECT-17K11853
[Journal Article] シェーグレン症候群における適応免疫と治療への展望2020
- Author(s)
  竹下勝、鈴木勝也、竹内勤
- Journal Title
  
  リウマチ科
  
  Volume: 64 Pages: 552-558
- Data Source
  KAKENHI-PROJECT-20K17430
[Journal Article] Antigen-driven selection of antibodies against SSA, SSB and the centromere ‘complex’, including a novel antigen, MIS12 complex, in human salivary glands2019
- Author(s)
  Takeshita Masaru、Suzuki Katsuya、Kaneda Yukari、Yamane Humitsugu、Ikeura Kazuhiro、Sato Hidekazu、Kato Shin、Tsunoda Kazuyuki、Arase Hisashi、Takeuchi Tsutomu
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: 79 Issue: 1 Pages: 150-158
- DOI
  10.1136/annrheumdis-2019-215862
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11853, KAKENHI-PROJECT-18K19450, KAKENHI-PUBLICLY-19H04808, KAKENHI-PROJECT-18H05279, KAKENHI-PROJECT-17H04216
[Patent] 抗セントロメア抗体の標的抗原2020
- Inventor(s)
  梶尾暢彦、竹下勝、鈴木勝也、竹内勤
- Industrial Property Rights Holder
  梶尾暢彦、竹下勝、鈴木勝也、竹内勤
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-187199
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K17430
[Patent] 自己免疫疾患の検出剤となるタンパク質複合体、及びその使用2019
- Inventor(s)
  竹下　勝、竹内　勤、鈴木　勝也
- Industrial Property Rights Holder
  竹下　勝、竹内　勤、鈴木　勝也
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-107179
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17H04216
[Presentation] ARS抗体症候群の肺病変及び唾液腺病変における自己免疫応答の解析2023
- Author(s)
  竹下　勝、鈴木　勝也、中澤　真帆、金子　祐子
- Organizer
  第68回　日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-22K08528
[Presentation] Antigen-specificity of the antibodies produced in the disease lesion of patients with antisynthetase syndrome2022
- Author(s)
  Masaru Takeshita, Katsuya Suzuki, Maho Nakazawa, Yuko Kaneko
- Organizer
  第66回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K17430
[Presentation] Transcriptome analysis of alveolar macrophages identifies involvement of PD-1/PD-Ls in pathogenesis of rheumatoid arthritis-associated interstitial lung disease.2021
- Author(s)
  Maho Nakazawa, Katsuya Suzuki, Masaru Takeshita, Jun Inamo, Tsutomu Takeuchi.
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20H03720
[Presentation] Anti-centromere antibodies target centromere-kinetochore macrocomplex.2021
- Author(s)
  Nobuhiko Kajio, Masaru Takeshita, Katsuya Suzuki, Tsutomu Takeuchi
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K17430
[Presentation] Single-cell analysis of salivary gland epithelial cells revealed enhanced interferon signature and dysfunction of multipotent stem cells in Sjogren's syndrome.2021
- Author(s)
  Masaru Takeshita, Katsuya Suzuki, Tsutomu Takeuchi
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K17430
[Presentation] Antigen-driven autoantibody production in lung lesion of systemic autoimmune diseases.2020
- Author(s)
  Masaru Takeshita, Katsuya Suzuki, Maho Nakazawa, Tsutomu Takeuchi.
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20H03720
[Presentation] Comprehensive analysis of anti-centromere autoantibodies with the centromere protein library in Sjogren's syndrome, systemic sclerosis, and primary biliary cholangitis.2020
- Author(s)
  Nobuhiko Kajio, Masaru Takeshita, Katsuya Suzuki, Tsutomu Takeuchi.
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K17430
[Presentation] Differences of coinhibitory molecule expression on lung T cells from patients with rheumatoid arthritis- and idiopathic inflammatory myopathies-associated interstitial lung disease.2020
- Author(s)
  Maho Nakazawa, Masaru Takeshita, Katsuya Suzuki, Hisaji Oshima, Tsutomu Takeuchi.
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20H03720
[Presentation] Antigen-driven autoantibody production in lung lesion of systemic autoimmune diseases.2020
- Author(s)
  Masaru Takeshita, Katsuya Suzuki, Maho Nakazawa, Tsutomu Takeuchi.
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K17430
[Presentation] シェーグレン症候群の病変局所における自己抗体産生から明らかになった抗セントロメア抗体の疾患分類上の意義について2019
- Author(s)
  竹下　勝、鈴木　勝也、金田　由加梨、山根　史嗣、池浦　一裕、佐藤　秀和、加藤　伸、角田　和之、荒瀬　尚、竹内　勤
- Organizer
  第6回JCRベーシックリサーチカンファレンス
- Data Source
  KAKENHI-PROJECT-17H04216
[Presentation] Reactivity of antibodies in the salivary glands of Sjögren's syndrome reveals affinity maturation in disease lesion and the significance of anti-centromere “complex” antibody in disease classification.2019
- Author(s)
  Masaru Takeshita, Katsuya Suzuki, Tsutomu Takeuchi.
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17H04216
[Presentation] シェーグレン症候群の唾液腺における自己抗体産生2018
- Author(s)
  竹下　勝、鈴木　勝也、竹内　勤
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H04216
[Presentation] シェーグレン症候群の唾液腺における自己抗体産生2018
- Author(s)
  竹下勝
- Organizer
  第62回　日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K19609

1. 鈴木勝也 (70306695)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. Takeuchi Tsutomu (50179610)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. 中川種昭 (00227745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 仲哲治 (30303936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 浅川修一 (30231872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 近藤泰 (50626380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 金子祐子 (60317112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 三上洋平 (80528662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 二村圭祐 (00462713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ARASE Hisashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 角田和之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeshita Masaru 竹下 勝

TAKESHITA Masaru 竹下 勝

Research Projects

Research Products

Co-Researchers

Comprehensive Understanding of Host Immune-Gut Microbiota Interactions underlying Autoimmune Diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自己免疫疾患の病変部位における自己抗体の産生機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Single cell integrated analysis of antigen specificity and gene expression for the cure of autoimmune diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular signatures in pre-RA patients by multi-omics analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Multiomics analysis of auto reactive immune cells in the inflammatory sites in autoimmune diseases.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel antigen presentation mechanism in autoimmune diseases and its significancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of regulatory mechanism of secretary protein kinase and its application for treatment of rheumatoid arthritis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Immune evasion and chronological decrease in titer of neutralizing antibody against SARS-CoV-2 and its variants of concerns in COVID-19 patients2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nation-wide cohort study of remission induction therapy using rituximab in Japanese patients with antineutrophil cytoplasmic antibody associated vasculitis: Effectiveness and safety in the first 6 months2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct Expression of Coinhibitory Molecules on Alveolar T Cells in Patients With Rheumatoid Arthritis Associated and Idiopathic Inflammatory Myopathy Associated Interstitial Lung Disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antigen-driven autoantibody production in lungs of interstitial lung disease with autoimmune disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-centromere antibodies target centromere kinetochore macrocomplex: a comprehensive autoantigen profiling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] シェーグレン症候群における適応免疫と治療への展望2020

Author(s)

Journal Title

Data Source

[Journal Article] Antigen-driven selection of antibodies against SSA, SSB and the centromere ‘complex’, including a novel antigen, MIS12 complex, in human salivary glands2019

Author(s)

Journal Title

DOI

Takeshita Masaru 竹下勝

TAKESHITA Masaru 竹下勝

[Presentation] Reactivity of antibodies in the salivary glands of Sjögren's syndrome reveals affinity maturation in disease lesion and the significance of anti-centromere “complex” antibody in disease classification.2019