TAKAYAMA Naoya 高山直也

… Alternative Names

髙山直也タカヤマナオヤ

Takayama Naoya 高山直也

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Researcher Number	10584229
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 千葉大学, 大学院医学研究院, 准教授 2017 – 2020: 千葉大学, 大学院医学研究院, 講師 2012: 京都大学, iPS 細胞研究所, 助教 2011 – 2012: 京都大学, ｉＰＳ細胞研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 53020:Cardiology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Hematology / Pediatrics Except Principal Investigator Basic Section 56020:Orthopedics-related / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator エピゲノム / ヒト造血幹細胞 / 静止期 / オープンクロマチン解析 / CTCF / クロマチン / オルガノイド / 動脈硬化 / ウェルナー症候群 / レトロトランスポゾン … More / 血管細胞 / マクロファージ / ヒトiPS細胞 / 動脈硬化モデル / 間葉系幹細胞 / 造血支持細胞 / インターフェロンシグナル / HiC / クロマチンループ / 静止期制御 / 造血幹細胞 / エピゲノム解析 / 造血不全 / 赤血球分化 / 巨核球分化 / c-MPL / CAMT / 疾患特異的iPS細胞 … More Except Principal Investigator 血小板 / 再生医療 / 多血小板血漿 / 骨形成促進 / 骨癒合 / サイトカイン / iPS細胞由来血小板 / リンパ管腫症 / リンパ管 / ポドプラニン / CLEC-2 / リンパ管種症 / ゴーハム病 / AI / 骨再生 / 巨核球 / iPS細胞 / 骨 / PRP / 凍結乾燥 / 疼痛抑制 / 変形性膝関節症 / iPS細胞由来血小板製剤 / iPS細胞由来人工巨核球・血小板凍結乾燥製剤 / 骨癒合促進 Less

ヒトiPS細胞由来不老化細胞を用いた動脈硬化研究用プラットフォーム開発Principal Investigator
- Principal Investigator
  
  髙山直也
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Chiba University
Study of the regulation of self-renewal and differentiation of human hematopoietic stem cells via interferon signaling.Principal Investigator
- Principal Investigator
  
  高山直也
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
Elucidation of the pain suppressing effect of iPS platelet preparations on knee osteoarthritis
- Principal Investigator
  
  志賀康浩
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Chiba University
リンパ管腫症／ゴーハム病で認められた血小板活性化受容体CLEC-2異常の解析
- Principal Investigator
  
  井上克枝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
ヒトiPS細胞由来不老化マクロファージ/血管細胞からなる動脈硬化オルガノイド開発Principal Investigator
- Principal Investigator
  
  高山直也
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Chiba University
骨癒合促進特化型ユニバーサルiPS血小板製剤の開発
- Principal Investigator
  
  大鳥精司
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Chiba University
Study for the regulation of exit from quiescent self-renewing programs in human hematopoietic stem cells by chromatin looping factor, CTCFPrincipal Investigator
- Principal Investigator
  
  Takayama Naoya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
Development of iPS cell-derived platelet preparation with bone fusion promoting effect
- Principal Investigator
  
  Shiga Yasuhiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Chiba University
Study for self-renewal in human hematopoietic stem cells by genome wide epigenetic analysisPrincipal Investigator
- Principal Investigator
  
  Takayama Naoya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
CAMT-iPS Cells Exhibiting Defective MPL Signaling Dysregulate hematopoiesisPrincipal Investigator
- Principal Investigator
  
  TAKAYAMA Naoya
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2018 2013 2012 2011 Other

All Journal Article Presentation Book Patent

[Book] 実験医学2021
- Author(s)
  髙山　直也
- Total Pages
  137
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20K08705
[Journal Article] Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model2024
- Author(s)
  Sudip Kumar Paul, Motohiko Oshima, Ashwini Patil, Masamitsu Sone, Hisaya Kato, Yoshiro Maezawa, Hiyori Kaneko, Masaki Fukuyo, Bahityar Rahmutulla, Yasuo Ouchi, Kyoko Tsujimura, Mahito Nakanishi, Atsushi Kaneda, Atsushi Iwama, Koutaro Yokote*, Koji Eto*, Naoya Takayama*
- Journal Title
  
  Nature Communications
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18284
[Journal Article] Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs2021
- Author(s)
  Sone Masamitsu、Nakamura Sou、Umeda Sachiko、Ginya Harumi、Oshima Motohiko、Kanashiro Maria Alejandra、Paul Sudip Kumar、Hashimoto Kanae、Nakamura Emiri、Harada Yasuo、Tsujimura Kyoko、Saraya Atsunori、Yamaguchi Tomoyuki、Sugimoto Naoshi、Sawaguchi Akira、Iwama Atsushi、Eto Koji、Takayama Naoya
- Journal Title
  
  Stem Cell Reports
  
  Volume: 16 Issue: 12 Pages: 2861-2870
- DOI
  10.1016/j.stemcr.2021.11.001
- NAID
  120007177810
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18365, KAKENHI-PROJECT-20H03740, KAKENHI-PROJECT-20K08705, KAKENHI-PROJECT-21K08413, KAKENHI-PROJECT-21H05047
[Journal Article] The Effect of Megakaryocytes and Platelets Derived from Human-Induced Pluripotent Stem Cells on Bone Formation2021
- Author(s)
  Masashi Sato, Yasuhiro Shiga, Naoya Takayama, Masamitsu Sone, Kentaro Kosaka, Itsuro Motegi, Norichika Mizuki, Kazuhide Inage, Yawara Eguchi, Miyako Narita, Sumihisa Orita, Koji Eto, Seiji Ohtori
- Journal Title
  
  Spine Surgery and Related Research
  
  Volume: 5 Issue: 3 Pages: 196-204
- DOI
  10.22603/ssrr.2020-0226
- NAID
  130008044530
- ISSN
  2432-261X
- Year and Date
  2021-05-27
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09615, KAKENHI-PROJECT-18H04164
[Journal Article] 1.The transition from quiescent to activated states in human hematopoietic stem cells is governed by dynamic 3D genome reorganization.2021
- Author(s)
  Naoya Takayama, et al
- Journal Title
  
  Cell Stem Cell
  
  Volume: 28 Issue: 3 Pages: 488-501
- DOI
  10.1016/j.stem.2020.11.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08705
[Journal Article] Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.2013
- Author(s)
  Nishimura T, Koseki H, Nakauchi H.　他
- Journal Title
  
  Cell Stem Cell.
  
  Volume: 12 Issue: 1 Pages: 114-26
- DOI
  10.1016/j.stem.2012.11.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23591413, KAKENHI-PROJECT-23592022, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24390257, KAKENHI-PLANNED-23106004
[Journal Article] Role of SOX17 in hematopoietic development from human embryonic stem cells.2013
- Author(s)
  Nakajima-Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, Endo TA, Takayama N, Eto K, Toyoda T, Koseki H, Nakauchi H, Iwama A.
- Journal Title
  
  Blood.
  
  Volume: 121 Issue: 3 Pages: 447-58
- DOI
  10.1182/blood-2012-05-431403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791071, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24591381, KAKENHI-PLANNED-23106004, KAKENHI-PUBLICLY-23130502, KAKENHI-PUBLICLY-24116711
[Journal Article] CAMT-iPS Cells Exhibiting Defective MPL Signaling Dysregulate Megakaryopoiesis and Erythropoiesis.2013
- Author(s)
  Hirata S., Takayama N.(Corresponding author),Jono-Ohnishi R., Endo H., Nakamura S., Dohda T., Nishi M., Hamazaki Y., IshiiE.,Kaneko S., Otsu M., NakauchiH.,Kunishima S., and Eto K.
- Journal Title
  
  Journal of Clinical Investigation
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application2012
- Author(s)
  Takayama N, Eto K
- Journal Title
  
  Cell Mol Life Sci
  
  Volume: 69(20) Issue: 20 Pages: 3419-28
- DOI
  10.1007/s00018-012-0995-4
- NAID
  120004920418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24300160, KAKENHI-PLANNED-23106004
[Journal Article] In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells.2012
- Author(s)
  Takayama N, Eto K.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 788 Pages: 205-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.2012
- Author(s)
  Nishimura S, Manabe I,Takayama N, Eto K, Nagai R. et al.
- Journal Title
  
  Blood
  
  Volume: 119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.2012
- Author(s)
  Kajiwara M
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 109 Issue: 31 Pages: 12538-12543
- DOI
  10.1073/pnas.1209979109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-24659133, KAKENHI-PROJECT-24659675, KAKENHI-PROJECT-24790276, KAKENHI-PLANNED-22110007, KAKENHI-PLANNED-23106004, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002
[Journal Article] PKA/CREB Signaling Triggers Initiation of Endothelial and Hematopoietic Cell Differentiation via Etv2 Induction.2012
- Author(s)
  Yamamizu K, Matsunaga T, Katayama S, Kataoka H, Takayama N, Eto K, Nishikawa S, Yamashita JK.
- Journal Title
  
  Stem cells
  
  Volume: 30 Pages: 687-696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia2012
- Author(s)
  Keiki Kumano
- Journal Title
  
  BLOOD
  
  Volume: 119 Issue: 26 Pages: 6234-6242
- DOI
  10.1182/blood-2011-07-367441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591026, KAKENHI-PROJECT-23591369, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23790775, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24249055, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24659127, KAKENHI-PROJECT-24659457, KAKENHI-PROJECT-24659489, KAKENHI-PLANNED-23106004, KAKENHI-PUBLICLY-23112504, KAKENHI-PUBLICLY-23130503
[Journal Article] Constitutive STAT5A activation enables erythropoiesis from human embryonic stem cell-derived primitive hematopoietic cells in the absence of erythropoietin.2011
- Author(s)
  Shimizu T., Sano S., Takayama N., Kaneko S., Eto K., Takeuchi Y., and Nakauchi H.
- Journal Title
  
  Kitasato Medical Journal
  
  Volume: 41 Pages: 42-49
- NAID
  40018724979
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] 「ヒト多能性幹細胞を用いた巨核球/血小板造血研究」2011
- Author(s)
  高山直也、江藤浩之
- Journal Title
  
  医学のあゆみ
  
  Volume: 239
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] Heterozygous ITGA2B R995W mutation inducing constitutive activation of the {alpha}IIb{beta}3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia.2011
- Author(s)
  Kunishima S, Kashiwagi H, Otsu M, Takayama N, Eto K, Onodera M, Miyajima Y, Takamatsu Y, Suzumiya J, Matsubara K, Tomiyama Y, Saito H.
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 5479-5484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] 「ヒトiPS細胞を用いた血小板再生」2011
- Author(s)
  高山直也、江藤浩之、中内啓光
- Journal Title
  
  日本臨床
  
  Volume: 69 Pages: 2161-2165
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] 「ヒトiPS細胞からの止血効果を持つ血小板の生成」2011
- Author(s)
  高山直也、江藤浩之
- Journal Title
  
  血液内科
  
  Volume: 63 Pages: 339-343
- Data Source
  KAKENHI-PROJECT-23791154
[Patent] 細胞分化度の調節方法2023
- Inventor(s)
  髙山直也,Sudip Kumar Paul,中村壮
- Industrial Property Rights Holder
  髙山直也,Sudip Kumar Paul,中村壮
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K18284
[Patent] 血小板産生の場構築の為の巨核球細胞の多核化の促進法2011
- Inventor(s)
  江藤浩之、中内啓光、高山直也、中村壮
- Industrial Property Rights Holder
  江藤浩之、中内啓光、高山直也、中村壮
- Industrial Property Number
  2011-108253
- Filing Date
  2011
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] ヒトiPS細胞由来巨核球・血小板製剤とリコンビナントBMP-2製剤の骨再生能と安全性についての検討2024
- Author(s)
  向井務晃, 水木誉凡, 志賀康浩, 田代奨, 新井隆仁, 小坂健太朗, 稲毛一秀, 高山直也, 江藤浩之, 大鳥精司
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K24452
[Presentation] ヒトiPS細胞由来血小板・巨核球製剤による骨形成促進機序の詳細な検討製剤含有サイトカイン非依存的な経路は存在するのか?2023
- Author(s)
  向井務晃, 志賀康浩, 田代奨, 新井隆仁, 小坂健太朗, 稲毛一秀, 折田純久, 江口和, 高山直也, 江藤浩之
- Organizer
  第38回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K24452
[Presentation] ヒトiPS細胞由来巨核球・血小板製剤とBMP-2の骨再生能と安全性についての検討2023
- Author(s)
  向井務晃, 志賀康浩, 江口和, 水木誉凡, 小坂健太朗, 稲毛一秀, 折田純久, 高山直也, 江藤浩之, 大鳥精司
- Organizer
  第42回日本運動器移植・再生医学研究会
- Data Source
  KAKENHI-PROJECT-23K24452
[Presentation] 骨癒合特化型iPS細胞由来血小板製剤の開発2023
- Author(s)
  志賀康浩, 新井隆仁, 田代奬, 高山直也, 向井務晃, 佐藤雅, 水木誉凡, 小田切拓磨, 折田純久, 稲毛一秀, 江口和, 井上雅寛, 江藤浩之, 大鳥精司
- Organizer
  第52回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24452
[Presentation] ラット腰椎後側方固定モデルにおけるiPS細胞由来血小板/巨核球製剤の作製スケールの違いによる骨形成促進効果の比較検討2023
- Author(s)
  向井務晃, 新井隆仁, 志賀康浩, 井上雅寛, 稲毛一秀, 折田純久, 江口和, 高山直也, 江藤浩之, 大鳥精司
- Organizer
  第42回日本運動器移植・再生医学研究会
- Data Source
  KAKENHI-PROJECT-23K24452
[Presentation] ラット腰椎後側方固定モデルにおけるiPS細胞由来血小板/巨核球製剤の異なる作成スケールでの骨形成促進効果の検討2023
- Author(s)
  新井隆仁, 向井務晃, 高山直也, 志賀康浩, 折田純久, 成田都, 稲毛一秀, 田代奨, 江藤浩之, 大鳥精司
- Organizer
  第38回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K24452
[Presentation] ヒトiPS細胞由来血小板・巨核球製剤による骨形成促進機序の詳細な検討2023
- Author(s)
  向井務晃, 志賀康浩, 江口和, 新井隆仁, 小坂健太朗, 稲毛一秀, 折田純久, 高山直也, 江藤浩之, 大鳥精司
- Organizer
  第42回日本運動器移植・再生医学研究会
- Data Source
  KAKENHI-PROJECT-23K24452
[Presentation] 脊椎・脊髄領域における最新の再生医療・細胞治療　PRPを用いた脊椎固定　iPS細胞由来血小板製剤の可能性2023
- Author(s)
  志賀康浩, 高山直也, 向井務晃, 新井隆仁, 田代奨, 佐藤雅, 水木誉凡, 折田純久, 稲毛一秀, 江藤浩之, 大鳥精司
- Organizer
  第38回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K24452
[Presentation] ヒトiPS細胞由来巨核球・血小板製剤とBMP-2の骨再生能と安全性についての検討2022
- Author(s)
  向井務晃, 水木誉凡, 高山直也, 志賀康浩, 小坂健太朗, 稲毛一秀, 江口和, 折田純久, 大鳥精司, 江藤浩之
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K24452
[Presentation] The combined bone forming capability of human-induced pluripotent stem cells-derived platelets and human bone morphogenetic proteins-22022
- Author(s)
  Michiaki Mukai, Norichika Mizuki, Yasuhiro Shiga, Kentaro Kosaka, Naoya Takayama, Seiji Ohtori, Koji Eto
- Organizer
  The 19th Stem Cell Research Symposium
- Data Source
  KAKENHI-PROJECT-23K24452
[Presentation] iPS細胞由来血小板製剤は骨癒合促進効果を有する　自己血由来多血小板血漿を凌駕する組織修復効果の可能性2021
- Author(s)
  志賀康浩，佐藤雅，水木誉凡，折田純久，稲毛一秀，江口和，金勤東，穂積崇史，小田切拓磨，向畑智仁，牧聡，古矢丈雄，小坂健太朗，高山直也，江藤浩之，大鳥精司
- Organizer
  第50回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09615
[Presentation] iPS細胞由来巨核球・血小板製剤の骨癒合促進効果2021
- Author(s)
  志賀康浩，佐藤雅，水木誉凡，折田純久，稲毛一秀，江口和，穂積崇史，金勤東，江藤浩之，高山直也，小坂健太朗，大鳥精司
- Organizer
  第94回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09615
[Presentation] The Platelet derived from induced pluripotent stem cells accelerates bone union with adequate rigidity in posterolateral lumbar fusion surgery model in rats2021
- Author(s)
  Yasuhiro Shiga, Masashi Sato, Norichika Mizuki, Sumihisa Orita, Kazuhide Inage, Yawara Eguchi, Miyako Narita, Takashi Hozumi, Geundong Kim, Takuma Odagiri, Tomohito Mukaihata, Satoshi Maki, Takeo Furuya, Kentaro Kosaka, Naoya Takayama, Koji Eto, Seiji Ohtori
- Organizer
  ISSLS Anual meeting2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09615
[Presentation] CTCFによるヒト造血幹細胞の静止期離脱機構の解明2020
- Author(s)
  髙山　直也
- Organizer
  第24回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-17K09899
[Presentation] A new role for CTCF as a gatekeeper of stemness in human hematopoietic stem cells2018
- Author(s)
  髙山　直也
- Organizer
  日本血液学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09899
[Presentation] A new role for CTCF as a gatekeeper of stemness in human hematopoietic stem cells2018
- Author(s)
  髙山　直也
- Organizer
  JSHIH2018
- Data Source
  KAKENHI-PROJECT-17K09899
[Presentation] Chromatin transitions define a functional role for CFTC in regulating human hematopoietic stem cell function2018
- Author(s)
  高山　直也
- Organizer
  2018年度　日本血液学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09899
[Presentation] Human induced pluripotent stem cell-derived blood cells toward clinical application2011
- Author(s)
  Takayama N.
- Organizer
  17th International Symposium on Gnotobiology and 34th Congress of the Society for Microbial Ecology and Disease.(招待講演)
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Suspected incomplete reprogramming in blood-derived human induced pluripotent stem cells is advantageous for adult-type erythrocyte generation with globin switching2011
- Author(s)
  Takayama N, Sano S, Shimizu T., Kawahata R., Endo H., Nakamura S., Ogawa S., Nakauchi H., and Eto K.
- Organizer
  International Society for Stem Cell Research 9th Annual Meeting (ISSCR)
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] TRANSIENT ACTIVATION OF C-MYC EXPRESSION IS CRITICAL FOR EFFICIENT PLATELET GENERATION FROM HUMAN INDUCED PLURIPOTENT STEM CELLS2011
- Author(s)
  Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] 輸血医療革命をもたらす多能性幹細胞由来不死化巨核球細胞株樹立技術の開発
- Author(s)
  中村壮、高山直也、中内啓光、江藤浩之
- Organizer
  第32回日本炎症・再生医学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Modeling Congenital Amegakaryocytic Thrombocytopenia Using Patient-Specific Induced Pluripotent Stem Cells
- Author(s)
  Naoya Takayama, Shinji Hirata, Ryoko Jono-Ohnishi, Eiichi Ishii, Hiromitsu Nakauchi, Shinji Kunishima, and Koji Eto et.al
- Organizer
  53rd ASH Annual Meeting and Exposition.
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Stepwise Signaling and Low Oxygen Promote Hematopoietic Progenitor Emergence From Human Pluripotent Stem Cells
- Author(s)
  Hiroshi Endo, Naoya Takayama, Tomo Koike, Hiromitsu Nakauchi, and Koji Eto
- Organizer
  53rd ASH Annual Meeting and Exposition.
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Continuous Inhibition of ADAM17 Using a Novel Selective Inhibitor Restores Functional Platelet Yield From Human Pluripotent Stem Cells
- Author(s)
  Shinji Hirata, Ryoko Jono-Ohnishi, Satoshi Nishimura, Naoya Takayama, Sou Nakamura, Hiromitsu Nakauchi, Takahiko Murata, and Koji Eto
- Organizer
  53rd ASH Annual Meeting and Exposition.
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] In Vitro Generation of Mature T Lymphocytes From Human Ips Cells and Genetic Analysis of TCR Gene Rearrangements
- Author(s)
  Toshinobu Nishimura, Shin Kaneko, Yoko Tajima, Naoya Takayama, Ai Tachikawa-Kawana, Koji Eto, and Hiromitsu Nakauchi.
- Organizer
  53rd ASH Annual Meeting and Exposition.
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Platelet Production System Using an Immortalized Megakaryocyte Cell Line Derived From Human Pluripotent Stem Cells
- Author(s)
  Nakamura S., Takayama N.（発表者）,, Nakauchi H., and Eto K.
- Organizer
  53rd ASH Annual Meeting and Exposition
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Platelet transfusion system using an immortalized megakaryocyte cell line derived from hESCs/iPSCs
- Author(s)
  Sou Nakamura, Naoya Takayama, Hiromitsu Nakauchi, Koji Eto
- Organizer
  第７３回日本血液学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23791154

1. Shiga Yasuhiro (90568669)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
2. 大鳥精司 (40361430)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. 折田純久 (60638310)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 稲毛一秀 (80793629)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 中村壮 (50769833)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 向井務晃 (40907698)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
7. 曽根正光 (90599771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大島基彦 (70506287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 江口和 (40507323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 井上雅寛 (40797114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 川上英良 (30725338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 江藤浩之 (50286986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
13. 井上克枝 (10324211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 大石沙織 (50894094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 築地長治 (20710362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 小関道夫 (60444303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 斎藤潤 (90535486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. PAUL SUDIP

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 古関明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TAKAYAMA Naoya 高山 直也

髙山 直也 タカヤマ ナオヤ

Takayama Naoya 高山 直也

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Co-Researchers

ヒトiPS細胞由来不老化細胞を用いた動脈硬化研究用プラットフォーム開発Principal Investigator

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Study of the regulation of self-renewal and differentiation of human hematopoietic stem cells via interferon signaling.Principal Investigator

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Elucidation of the pain suppressing effect of iPS platelet preparations on knee osteoarthritis

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リンパ管腫症／ゴーハム病で認められた血小板活性化受容体CLEC-2異常の解析

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ヒトiPS細胞由来不老化マクロファージ/血管細胞からなる動脈硬化オルガノイド開発Principal Investigator

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骨癒合促進特化型ユニバーサルiPS血小板製剤の開発

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Study for the regulation of exit from quiescent self-renewing programs in human hematopoietic stem cells by chromatin looping factor, CTCFPrincipal Investigator

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Development of iPS cell-derived platelet preparation with bone fusion promoting effect

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Study for self-renewal in human hematopoietic stem cells by genome wide epigenetic analysisPrincipal Investigator

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CAMT-iPS Cells Exhibiting Defective MPL Signaling Dysregulate hematopoiesisPrincipal Investigator

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[Book] 実験医学2021

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[Journal Article] Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model2024

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[Journal Article] Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs2021

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TAKAYAMA Naoya 高山直也

髙山直也タカヤマナオヤ

Takayama Naoya 高山直也