TAKAYAMA Naoya 高山直也

… Alternative Names

Researcher Number	10584229
Other IDs
Affiliation (Current)	2019: 千葉大学, 大学院医学研究院, 講師
Affiliation (based on the past Project Information) *help	2019: 千葉大学, 大学院医学研究院, 講師 2017: 千葉大学, 大学院医学研究院, 講師 2012: 京都大学, iPS 細胞研究所, 助教 2011 – 2012: 京都大学, ｉＰＳ細胞研究所, 助教
Review Section/Research Field	Principal Investigator Pediatrics / Hematology Except Principal Investigator Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator 疾患特異的iPS細胞 / CAMT / c-MPL / 巨核球分化 / 赤血球分化 / 造血不全 / ヒト造血幹細胞 / エピゲノム解析 / CTCF / エピゲノム … More Except Principal Investigator … More

iPS細胞由来多血小板血漿の開発と骨癒合促進効果に関する研究Ongoing
- Principal Investigator
  
  志賀康浩
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Chiba University
エピゲノム情報を基にしたヒト造血幹細胞の自己複製機構の解明を目指した研究Principal InvestigatorOngoing
- Principal Investigator
  
  高山直也
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
CAMT-iPS Cells Exhibiting Defective MPL Signaling Dysregulate hematopoiesisPrincipal Investigator
- Principal Investigator
  
  TAKAYAMA Naoya
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University

All 2018 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Generation of rejuvenated antigen-specific T cells by pluripotency reprogramming and dedifferentiation.2013
- Author(s)
  Nishimura T, Koseki H, Nakauchi H.　他
- Journal Title
  
  Cell StemCell.
  
  Volume: 12 Pages: 114-126
- DOI
  10.1016/j.stem.2012.11.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23591413, KAKENHI-PROJECT-23592022, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24390257, KAKENHI-PLANNED-23106004
[Journal Article] Manipulation of hematopoietic stem cells for regenerative medicine2013
- Author(s)
  Nakajima-Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, Endo TA, Takayama N, Eto K, Toyoda T, Koseki H, Nakauchi H, Iwama A.
- Journal Title
  
  Blood
  
  Volume: 121 Pages: 447-458
- DOI
  10.1182/blood-2012-05-431403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791071, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24591381, KAKENHI-PLANNED-23106004, KAKENHI-PUBLICLY-23130502, KAKENHI-PUBLICLY-24116711
[Journal Article] Development of Sendai virus vectors and their potential applications in gene therapy and regenerative medicine.2013
- Author(s)
  Keiki Kumano
- Journal Title
  
  Curr Gene Ther.
  
  Volume: 119 Pages: 6234-42
- DOI
  10.1182/blood-2011-07-367441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591026, KAKENHI-PROJECT-23591369, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23790775, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24249055, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24659127, KAKENHI-PROJECT-24659457, KAKENHI-PROJECT-24659489, KAKENHI-PLANNED-23106004, KAKENHI-PUBLICLY-23112504, KAKENHI-PUBLICLY-23130503
[Journal Article] CAMT-iPS Cells Exhibiting Defective MPL Signaling Dysregulate Megakaryopoiesis and Erythropoiesis.2013
- Author(s)
  Hirata S., Takayama N.(Corresponding author),Jono-Ohnishi R., Endo H., Nakamura S., Dohda T., Nishi M., Hamazaki Y., IshiiE.,Kaneko S., Otsu M., NakauchiH.,Kunishima S., and Eto K.
- Journal Title
  
  Journal of Clinical Investigation
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application.2012
- Author(s)
  Takayama N, Eto K
- Journal Title
  
  Cell Mol Life Sci.
  
  Volume: 69(20) Pages: 3419-28
- DOI
  10.1007/s00018-012-0995-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24300160, KAKENHI-PLANNED-23106004
[Journal Article] In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells.2012
- Author(s)
  Takayama N, Eto K.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 788 Pages: 205-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.2012
- Author(s)
  Nishimura S, Manabe I,Takayama N, Eto K, Nagai R. et al.
- Journal Title
  
  Blood
  
  Volume: 119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] Donor- dependent variations in hepatic differentiation fromhumaninduced pluripotent stemcells.2012
- Author(s)
  Kajiwara M
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 109 Pages: 12538-12543
- DOI
  10.1073/pnas.1209979109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-24659133, KAKENHI-PROJECT-24659675, KAKENHI-PROJECT-24790276, KAKENHI-PLANNED-22110007, KAKENHI-PLANNED-23106004, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002
[Journal Article] PKA/CREB Signaling Triggers Initiation of Endothelial and Hematopoietic Cell Differentiation via Etv2 Induction.2012
- Author(s)
  Yamamizu K, Matsunaga T, Katayama S, Kataoka H, Takayama N, Eto K, Nishikawa S, Yamashita JK.
- Journal Title
  
  Stem cells
  
  Volume: 30 Pages: 687-696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] Constitutive STAT5A activation enables erythropoiesis from human embryonic stem cell-derived primitive hematopoietic cells in the absence of erythropoietin.2011
- Author(s)
  Shimizu T., Sano S., Takayama N., Kaneko S., Eto K., Takeuchi Y., and Nakauchi H.
- Journal Title
  
  Kitasato Medical Journal
  
  Volume: 41 Pages: 42-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] 「ヒト多能性幹細胞を用いた巨核球/血小板造血研究」2011
- Author(s)
  高山直也、江藤浩之
- Journal Title
  
  医学のあゆみ
  
  Volume: 239
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] Heterozygous ITGA2B R995W mutation inducing constitutive activation of the {alpha}IIb{beta}3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia.2011
- Author(s)
  Kunishima S, Kashiwagi H, Otsu M, Takayama N, Eto K, Onodera M, Miyajima Y, Takamatsu Y, Suzumiya J, Matsubara K, Tomiyama Y, Saito H.
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 5479-5484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] 「ヒトiPS細胞を用いた血小板再生」2011
- Author(s)
  高山直也、江藤浩之、中内啓光
- Journal Title
  
  日本臨床
  
  Volume: 69 Pages: 2161-2165
- Data Source
  KAKENHI-PROJECT-23791154
[Journal Article] 「ヒトiPS細胞からの止血効果を持つ血小板の生成」2011
- Author(s)
  高山直也、江藤浩之
- Journal Title
  
  血液内科
  
  Volume: 63 Pages: 339-343
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Chromatin transitions define a functional role for CFTC in regulating human hematopoietic stem cell function2018
- Author(s)
  高山　直也
- Organizer
  2018年度　日本血液学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09899
[Presentation] Human induced pluripotent stem cell-derived blood cells toward clinical application2011
- Author(s)
  Takayama N.
- Organizer
  17th International Symposium on Gnotobiology and 34th Congress of the Society for Microbial Ecology and Disease.(招待講演)
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Suspected incomplete reprogramming in blood-derived human induced pluripotent stem cells is advantageous for adult-type erythrocyte generation with globin switching2011
- Author(s)
  Takayama N, Sano S, Shimizu T., Kawahata R., Endo H., Nakamura S., Ogawa S., Nakauchi H., and Eto K.
- Organizer
  International Society for Stem Cell Research 9th Annual Meeting (ISSCR)
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] TRANSIENT ACTIVATION OF C-MYC EXPRESSION IS CRITICAL FOR EFFICIENT PLATELET GENERATION FROM HUMAN INDUCED PLURIPOTENT STEM CELLS2011
- Author(s)
  Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] 輸血医療革命をもたらす多能性幹細胞由来不死化巨核球細胞株樹立技術の開発
- Author(s)
  中村壮、高山直也、中内啓光、江藤浩之
- Organizer
  第32回日本炎症・再生医学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Modeling Congenital Amegakaryocytic Thrombocytopenia Using Patient-Specific Induced Pluripotent Stem Cells
- Author(s)
  Naoya Takayama, Shinji Hirata, Ryoko Jono-Ohnishi, Eiichi Ishii, Hiromitsu Nakauchi, Shinji Kunishima, and Koji Eto et.al
- Organizer
  53rd ASH Annual Meeting and Exposition.
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Stepwise Signaling and Low Oxygen Promote Hematopoietic Progenitor Emergence From Human Pluripotent Stem Cells
- Author(s)
  Hiroshi Endo, Naoya Takayama, Tomo Koike, Hiromitsu Nakauchi, and Koji Eto
- Organizer
  53rd ASH Annual Meeting and Exposition.
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Continuous Inhibition of ADAM17 Using a Novel Selective Inhibitor Restores Functional Platelet Yield From Human Pluripotent Stem Cells
- Author(s)
  Shinji Hirata, Ryoko Jono-Ohnishi, Satoshi Nishimura, Naoya Takayama, Sou Nakamura, Hiromitsu Nakauchi, Takahiko Murata, and Koji Eto
- Organizer
  53rd ASH Annual Meeting and Exposition.
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] In Vitro Generation of Mature T Lymphocytes From Human Ips Cells and Genetic Analysis of TCR Gene Rearrangements
- Author(s)
  Toshinobu Nishimura, Shin Kaneko, Yoko Tajima, Naoya Takayama, Ai Tachikawa-Kawana, Koji Eto, and Hiromitsu Nakauchi.
- Organizer
  53rd ASH Annual Meeting and Exposition.
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Platelet Production System Using an Immortalized Megakaryocyte Cell Line Derived From Human Pluripotent Stem Cells
- Author(s)
  Nakamura S., Takayama N.（発表者）,, Nakauchi H., and Eto K.
- Organizer
  53rd ASH Annual Meeting and Exposition
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23791154
[Presentation] Platelet transfusion system using an immortalized megakaryocyte cell line derived from hESCs/iPSCs
- Author(s)
  Sou Nakamura, Naoya Takayama, Hiromitsu Nakauchi, Koji Eto
- Organizer
  第７３回日本血液学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23791154

1. 志賀康浩 (90568669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 大鳥精司 (40361430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 折田純久 (60638310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 稲毛一秀 (80793629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 曽根正光 (90599771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KANEKO Shin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. OSAWA Mitsujiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. AOI Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. OKITA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 古関明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 植村靖史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 江藤浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
13. 中内啓光

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
14. 戸田口淳也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 高橋和利

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# of Collaborated Products: 1 results
16. 井上治久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 熊野恵城

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# of Collaborated Products: 1 results
18. 上久保靖彦

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# of Collaborated Products: 1 results
19. 永江玄太

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# of Collaborated Products: 1 results
20. 大津真

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# of Collaborated Products: 1 results
21. 黒川峰夫

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# of Collaborated Products: 1 results

TAKAYAMA Naoya 高山 直也

高山 直也 タカヤマ ナオヤ

Research Projects

Research Products

Co-Researchers

iPS細胞由来多血小板血漿の開発と骨癒合促進効果に関する研究Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エピゲノム情報を基にしたヒト造血幹細胞の自己複製機構の解明を目指した研究Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CAMT-iPS Cells Exhibiting Defective MPL Signaling Dysregulate hematopoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Generation of rejuvenated antigen-specific T cells by pluripotency reprogramming and dedifferentiation.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Manipulation of hematopoietic stem cells for regenerative medicine2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of Sendai virus vectors and their potential applications in gene therapy and regenerative medicine.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CAMT-iPS Cells Exhibiting Defective MPL Signaling Dysregulate Megakaryopoiesis and Erythropoiesis.2013

Author(s)

Journal Title

Data Source

[Journal Article] Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells.2012

Author(s)

Journal Title

Data Source

[Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.2012

Author(s)

Journal Title

Data Source

[Journal Article] Donor- dependent variations in hepatic differentiation fromhumaninduced pluripotent stemcells.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PKA/CREB Signaling Triggers Initiation of Endothelial and Hematopoietic Cell Differentiation via Etv2 Induction.2012

Author(s)

Journal Title

Data Source

[Journal Article] Constitutive STAT5A activation enables erythropoiesis from human embryonic stem cell-derived primitive hematopoietic cells in the absence of erythropoietin.2011

Author(s)

Journal Title

Data Source

[Journal Article] 「ヒト多能性幹細胞を用いた巨核球/血小板造血研究」2011

Author(s)

Journal Title

Data Source

[Journal Article] Heterozygous ITGA2B R995W mutation inducing constitutive activation of the {alpha}IIb{beta}3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia.2011

Author(s)

Journal Title

Data Source

[Journal Article] 「ヒトiPS細胞を用いた血小板再生」2011

Author(s)

Journal Title

Data Source

TAKAYAMA Naoya 高山直也

高山直也タカヤマナオヤ