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TAKAYAMA Naoya  高山 直也

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高山 直也  タカヤマ ナオヤ

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Researcher Number 10584229
Other IDs
Affiliation (Current) 2019: 千葉大学, 大学院医学研究院, 講師
Affiliation (based on the past Project Information) *help 2019: 千葉大学, 大学院医学研究院, 講師
2017: 千葉大学, 大学院医学研究院, 講師
2012: 京都大学, iPS 細胞研究所, 助教
2011 – 2012: 京都大学, iPS細胞研究所, 助教
Review Section/Research Field
Principal Investigator
Pediatrics / Hematology
Except Principal Investigator
Basic Section 56020:Orthopedics-related
Keywords
Principal Investigator
疾患特異的iPS細胞 / CAMT / c-MPL / 巨核球分化 / 赤血球分化 / 造血不全 / ヒト造血幹細胞 / エピゲノム解析 / CTCF / エピゲノム … More
Except Principal Investigator
… More iPS細胞由来血小板 / 多血小板血漿 / 骨癒合促進 / 再生医療 Less
  • Research Projects

    (3 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (21 People)
  •  iPS細胞由来多血小板血漿の開発と骨癒合促進効果に関する研究Ongoing

    • Principal Investigator
      志賀 康浩
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Chiba University
  •  エピゲノム情報を基にしたヒト造血幹細胞の自己複製機構の解明を目指した研究Principal InvestigatorOngoing

    • Principal Investigator
      高山 直也
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  CAMT-iPS Cells Exhibiting Defective MPL Signaling Dysregulate hematopoiesisPrincipal Investigator

    • Principal Investigator
      TAKAYAMA Naoya
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University

All 2018 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] Generation of rejuvenated antigen-specific T cells by pluripotency reprogramming and dedifferentiation.2013

    • Author(s)
      Nishimura T, Koseki H, Nakauchi H. 他
    • Journal Title

      Cell StemCell.

      Volume: 12 Pages: 114-126

    • DOI
      10.1016/j.stem.2012.11.002
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23591413, KAKENHI-PROJECT-23592022, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24390257, KAKENHI-PLANNED-23106004
  • [Journal Article] Manipulation of hematopoietic stem cells for regenerative medicine2013

    • Author(s)
      Nakajima-Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, Endo TA, Takayama N, Eto K, Toyoda T, Koseki H, Nakauchi H, Iwama A.
    • Journal Title

      Blood

      Volume: 121 Pages: 447-458

    • DOI
      10.1182/blood-2012-05-431403
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791071, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24591381, KAKENHI-PLANNED-23106004, KAKENHI-PUBLICLY-23130502, KAKENHI-PUBLICLY-24116711
  • [Journal Article] Development of Sendai virus vectors and their potential applications in gene therapy and regenerative medicine.2013

    • Author(s)
      Keiki Kumano
    • Journal Title

      Curr Gene Ther.

      Volume: 119 Pages: 6234-42

    • DOI
      10.1182/blood-2011-07-367441
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591026, KAKENHI-PROJECT-23591369, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23790775, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24249055, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24659127, KAKENHI-PROJECT-24659457, KAKENHI-PROJECT-24659489, KAKENHI-PLANNED-23106004, KAKENHI-PUBLICLY-23112504, KAKENHI-PUBLICLY-23130503
  • [Journal Article] CAMT-iPS Cells Exhibiting Defective MPL Signaling Dysregulate Megakaryopoiesis and Erythropoiesis.2013

    • Author(s)
      Hirata S., Takayama N.(Corresponding author),Jono-Ohnishi R., Endo H., Nakamura S., Dohda T., Nishi M., Hamazaki Y., IshiiE.,Kaneko S., Otsu M., NakauchiH.,Kunishima S., and Eto K.
    • Journal Title

      Journal of Clinical Investigation

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Journal Article] Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application.2012

    • Author(s)
      Takayama N, Eto K
    • Journal Title

      Cell Mol Life Sci.

      Volume: 69(20) Pages: 3419-28

    • DOI
      10.1007/s00018-012-0995-4
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24300160, KAKENHI-PLANNED-23106004
  • [Journal Article] In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells.2012

    • Author(s)
      Takayama N, Eto K.
    • Journal Title

      Methods Mol Biol.

      Volume: 788 Pages: 205-17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.2012

    • Author(s)
      Nishimura S, Manabe I,Takayama N, Eto K, Nagai R. et al.
    • Journal Title

      Blood

      Volume: 119

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Journal Article] Donor- dependent variations in hepatic differentiation fromhumaninduced pluripotent stemcells.2012

    • Author(s)
      Kajiwara M
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 109 Pages: 12538-12543

    • DOI
      10.1073/pnas.1209979109
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-24659133, KAKENHI-PROJECT-24659675, KAKENHI-PROJECT-24790276, KAKENHI-PLANNED-22110007, KAKENHI-PLANNED-23106004, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002
  • [Journal Article] PKA/CREB Signaling Triggers Initiation of Endothelial and Hematopoietic Cell Differentiation via Etv2 Induction.2012

    • Author(s)
      Yamamizu K, Matsunaga T, Katayama S, Kataoka H, Takayama N, Eto K, Nishikawa S, Yamashita JK.
    • Journal Title

      Stem cells

      Volume: 30 Pages: 687-696

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Journal Article] Constitutive STAT5A activation enables erythropoiesis from human embryonic stem cell-derived primitive hematopoietic cells in the absence of erythropoietin.2011

    • Author(s)
      Shimizu T., Sano S., Takayama N., Kaneko S., Eto K., Takeuchi Y., and Nakauchi H.
    • Journal Title

      Kitasato Medical Journal

      Volume: 41 Pages: 42-49

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Journal Article] 「ヒト多能性幹細胞を用いた巨核球/血小板造血研究」2011

    • Author(s)
      高山直也、江藤浩之
    • Journal Title

      医学のあゆみ

      Volume: 239

    • Data Source
      KAKENHI-PROJECT-23791154
  • [Journal Article] Heterozygous ITGA2B R995W mutation inducing constitutive activation of the {alpha}IIb{beta}3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia.2011

    • Author(s)
      Kunishima S, Kashiwagi H, Otsu M, Takayama N, Eto K, Onodera M, Miyajima Y, Takamatsu Y, Suzumiya J, Matsubara K, Tomiyama Y, Saito H.
    • Journal Title

      Blood

      Volume: 117 Pages: 5479-5484

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Journal Article] 「ヒトiPS細胞を用いた血小板再生」2011

    • Author(s)
      高山直也、江藤浩之、中内啓光
    • Journal Title

      日本臨床

      Volume: 69 Pages: 2161-2165

    • Data Source
      KAKENHI-PROJECT-23791154
  • [Journal Article] 「ヒトiPS細胞からの止血効果を持つ血小板の生成」2011

    • Author(s)
      高山直也、江藤浩之
    • Journal Title

      血液内科

      Volume: 63 Pages: 339-343

    • Data Source
      KAKENHI-PROJECT-23791154
  • [Presentation] Chromatin transitions define a functional role for CFTC in regulating human hematopoietic stem cell function2018

    • Author(s)
      高山 直也
    • Organizer
      2018年度 日本血液学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09899
  • [Presentation] Human induced pluripotent stem cell-derived blood cells toward clinical application2011

    • Author(s)
      Takayama N.
    • Organizer
      17th International Symposium on Gnotobiology and 34th Congress of the Society for Microbial Ecology and Disease.(招待講演)
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Presentation] Suspected incomplete reprogramming in blood-derived human induced pluripotent stem cells is advantageous for adult-type erythrocyte generation with globin switching2011

    • Author(s)
      Takayama N, Sano S, Shimizu T., Kawahata R., Endo H., Nakamura S., Ogawa S., Nakauchi H., and Eto K.
    • Organizer
      International Society for Stem Cell Research 9th Annual Meeting (ISSCR)
    • Place of Presentation
      Toronto, Canada
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Presentation] TRANSIENT ACTIVATION OF C-MYC EXPRESSION IS CRITICAL FOR EFFICIENT PLATELET GENERATION FROM HUMAN INDUCED PLURIPOTENT STEM CELLS2011

    • Author(s)
      Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.
    • Organizer
      XXIII Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Presentation] 輸血医療革命をもたらす多能性幹細胞由来不死化巨核球細胞株樹立技術の開発

    • Author(s)
      中村壮、高山直也、中内啓光、江藤浩之
    • Organizer
      第32回日本炎症・再生医学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Presentation] Modeling Congenital Amegakaryocytic Thrombocytopenia Using Patient-Specific Induced Pluripotent Stem Cells

    • Author(s)
      Naoya Takayama, Shinji Hirata, Ryoko Jono-Ohnishi, Eiichi Ishii, Hiromitsu Nakauchi, Shinji Kunishima, and Koji Eto et.al
    • Organizer
      53rd ASH Annual Meeting and Exposition.
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Presentation] Stepwise Signaling and Low Oxygen Promote Hematopoietic Progenitor Emergence From Human Pluripotent Stem Cells

    • Author(s)
      Hiroshi Endo, Naoya Takayama, Tomo Koike, Hiromitsu Nakauchi, and Koji Eto
    • Organizer
      53rd ASH Annual Meeting and Exposition.
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Presentation] Continuous Inhibition of ADAM17 Using a Novel Selective Inhibitor Restores Functional Platelet Yield From Human Pluripotent Stem Cells

    • Author(s)
      Shinji Hirata, Ryoko Jono-Ohnishi, Satoshi Nishimura, Naoya Takayama, Sou Nakamura, Hiromitsu Nakauchi, Takahiko Murata, and Koji Eto
    • Organizer
      53rd ASH Annual Meeting and Exposition.
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Presentation] In Vitro Generation of Mature T Lymphocytes From Human Ips Cells and Genetic Analysis of TCR Gene Rearrangements

    • Author(s)
      Toshinobu Nishimura, Shin Kaneko, Yoko Tajima, Naoya Takayama, Ai Tachikawa-Kawana, Koji Eto, and Hiromitsu Nakauchi.
    • Organizer
      53rd ASH Annual Meeting and Exposition.
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Presentation] Platelet Production System Using an Immortalized Megakaryocyte Cell Line Derived From Human Pluripotent Stem Cells

    • Author(s)
      Nakamura S., Takayama N.(発表者),, Nakauchi H., and Eto K.
    • Organizer
      53rd ASH Annual Meeting and Exposition
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-23791154
  • [Presentation] Platelet transfusion system using an immortalized megakaryocyte cell line derived from hESCs/iPSCs

    • Author(s)
      Sou Nakamura, Naoya Takayama, Hiromitsu Nakauchi, Koji Eto
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23791154
  • 1.  志賀 康浩 (90568669)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  大鳥 精司 (40361430)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  折田 純久 (60638310)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  稲毛 一秀 (80793629)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  曽根 正光 (90599771)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  KANEKO Shin
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  OSAWA Mitsujiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  AOI Takashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  OKITA Keisuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  古関 明彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 11.  植村 靖史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  江藤 浩之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 13.  中内 啓光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 14.  戸田口 淳也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  高橋 和利
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  井上 治久
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  熊野 恵城
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  上久保 靖彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  永江 玄太
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  大津 真
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  黒川 峰夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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