kobara hideki 小原英幹

… Alternative Names

Kobara Hideki 小原英幹

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Researcher Number	10612476
Other IDs
Affiliation (Current)	2025: 香川大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023: 香川大学, 医学部附属病院, 教授 2015 – 2023: 香川大学, 医学部附属病院, 講師
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Basic Section 59040:Nutrition science and health science-related / Tumor diagnostics Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 61010:Perceptual information processing-related / Gastroenterology
Keywords	Principal Investigator microRNA / 分子動態 / 早期発見 / 早期胃癌 / 生活習慣病 / ARB / 降圧薬 / 新規化学予防薬 / テルミサルタン / 化学予防薬 … More / 抗腫瘍薬 / 間葉系腫瘍 / 大腸癌 / バイオマーカー / exosome / 消化管間葉系腫瘍 / 消化管粘膜下腫瘍 … More Except Principal Investigator 肝細胞癌 / ガレクチン-9 / microRNA / micro RNA / 画像処理 / 3次元モデリング / 2点光源 / 3次元モデル / 内視鏡画像 / 腫瘍径 / 胃癌 / 耐性株 / 分子標的治療薬 / 抗がん作用 / 耐性癌細胞 / エピガロカテキンガレート / Galectin-9 / Galectin-9 microRNA / 胆管細胞癌 / エクソソーム / 転移性肝癌 / Ｇａｌ-9 / Ｇａｌ－９ / Gal-9 Less

内視鏡画像診断に向けた腫瘍の3次元モデル化手法の構築
- Principal Investigator
  
  高橋悟
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 61010:Perceptual information processing-related
- Research Institution
  Kagawa University
Investigation of relevant microRNAs and molecular mechanism for detecting early gastric carcinomaPrincipal Investigator
- Principal Investigator
  
  小原英幹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kagawa University
Examination of the effect of combination therapy of galectin-9 and epigallocatechin gallate on hepatocellular carcinoma
- Principal Investigator
  
  正木勉
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kagawa University
Anti-tumor effect of Galectin-9 on metastatic hepatocellular carcinoma and its microRNA basis
- Principal Investigator
  
  Masaki Tsutomu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kagawa University
Antitumor effects of lifestyle drugs on colorectal cancer: Involvement of antihypertensive drug ARB as a novel chemopreventive agentPrincipal Investigator
- Principal Investigator
  
  Kobara Hideki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kagawa University
Basic study on treatment of hepatocellular carcinoma targetted of Gal-9 exosomes
- Principal Investigator
  
  Masaki Tsutomu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kagawa University
Elucidation of pathway and prognostic factor prediction derived from microRNA analysis in gastrointestinal submucosal tumorPrincipal Investigator
- Principal Investigator
  
  Kobara Hideki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Kagawa University

All 2024 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Antihypertensive drug telmisartan inhibits cell proliferation of gastrointestinal stromal tumor cells in?vitro2020
- Author(s)
  Kobara Hideki, Fujihara Shintaro, Masaki Tsutomu, et al.
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 22 Issue: 2 Pages: 1063-1071
- DOI
  10.3892/mmr.2020.11144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11023
[Journal Article] Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo.2019
- Author(s)
  Matsui T, Chiyo T, Kobara H, Fujihara S, Fujita K, Namima D, Nakahara M, Kobayashi N, Nishiyama N, Yachida T, Morishita A, Iwama H, Masaki T.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20 Issue: 13 Pages: 13-13
- DOI
  10.3390/ijms20133197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11023
[Journal Article] Galectin-9 Induces Mitochondria-Mediated Apoptosis of Esophageal Cancer In Vitro and In Vivo in a Xenograft Mouse Model.2019
- Author(s)
  Chiyo T, Fujita K, Iwama H, Fujihara S, Tadokoro T, Ohura K, Matsui T, Goda Y, Kobayashi N, Nishiyama N, Yachida T, Morishita A, Kobara H, Mori H, Niki T, Hirashima M, Himoto T, Masaki T.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20 Issue: 11 Pages: 11-11
- DOI
  10.3390/ijms20112634
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11023, KAKENHI-PROJECT-19K16747
[Journal Article] Therapeutic potential of the antidiabetic drug metformin in small bowel adenocarcinoma.2017
- Author(s)
  Chiyo T, Kato K, Iwama H, Fujihara S, Fujita K, Tadokoro T, Ohura K, Samukawa E, Yamana Y, Kobayashi N, Matsunaga T, Nishiyama N, Ayaki M, Yachida T, Morishita A, Kobara H, Mori H, Masaki T.
- Journal Title
  
  Int J Oncol
  
  Volume: 50(6) Issue: 6 Pages: 2145-2153
- DOI
  10.3892/ijo.2017.3971
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09361
[Journal Article] Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells.2017
- Author(s)
  Akashi E, Fujihara S, Morishita A, Tadokoro T, Chiyo T, Fujikawa K, Kobara H, Mori H, Iwama H, Okano K, Suzuki Y, Niki T, Hirashima M, Masaki T.
- Journal Title
  
  Oncol Rep
  
  Volume: 38(1) Issue: 1 Pages: 506-514
- DOI
  10.3892/or.2017.5689
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09361
[Journal Article] icroRNA profile of hepatic epithelioid hemangioendothelioma: A case report.2017
- Author(s)
  Morishita A, Iwama H, Yoneyama H, Sakamoto T, Fujita K, Nomura T, Tani J, Miyoshi H, Fujihara S, Nishiyama N, Kobara H, Mori H, Yamamoto N, Okano K, Suzuki Y, Ibuki E, Haba R, Himoto T, Masaki T.
- Journal Title
  
  Oncol Lett
  
  Volume: 13(3) Issue: 3 Pages: 1655-1659
- DOI
  10.3892/ol.2017.5643
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09361
[Journal Article] Comparison of submucosal tunneling biopsy versus EUS-guided FNA for gastric subepithelial lesions: a prospective study with crossover design2017
- Author(s)
  Kobara Hideki、Mori Hirohito、Nishimoto Naoki、Fujihara Shintaro、Nishiyama Noriko、Ayaki Maki、Yachida Tatsuo、Matsunaga Tae、Chiyo Taiga、Kobayashi Nobuya、Fujita Koji、Kato Kiyohito、Kamada Hideki、Oryu Makoto、Tsutsui Kunihiko、Iwama Hisakazu、Haba Reiji、Masaki Tsutomu
- Journal Title
  
  Endoscopy International Open
  
  Volume: 05 Issue: 08 Pages: E695-E705
- DOI
  10.1055/s-0043-112497
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06855
[Journal Article] Galectin-9 suppresses the proliferation of gastric cancer cells in vitro.2016
- Author(s)
  Takano J, Morishita A, Fujihara S, Iwama H, Kokado F, Fujikawa K, Fujita K, Chiyo T, Tadokoro T, Sakamoto T, Nomura T, Tani J, Miyoshi H, Yoneyama H, Kobara H, Mori H, Niki T, Hirashima M, Masaki T.
- Journal Title
  
  Oncol Rep
  
  Volume: 35 Issue: 2 Pages: 851-860
- DOI
  10.3892/or.2015.4452
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460592, KAKENHI-PROJECT-16K09361
[Journal Article] Differences in miRNA expression profiles between GIST and leiomyoma in human samples acquired by submucosal tunneling biopsy.2015
- Author(s)
  Fujita K, Kobara H, Masaki T, et al.
- Journal Title
  
  Endosc Int Open.
  
  Volume: 6 Issue: 06 Pages: 665-671
- DOI
  10.1055/s-0034-1393077
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06855
[Presentation] 内視鏡画像の陰影特性を利用した腫瘍の３次元モデル化と腫瘍径の測定の実現化2024
- Author(s)
  小原英幹, 山田悠太, 亀割隆世, 中谷夏帆, 髙橋悟
- Organizer
  第20回日本消化管学会総会
- Data Source
  KAKENHI-PROJECT-23K11148
[Presentation] 炎症性腸疾患の診断、鑑別における血清microRNA のバイオマーカーとしての同定2018
- Author(s)
  谷内田達夫、藤森絢子、小林伸也、千代大翔、西山典子、小原英幹、森　宏仁、岩間久和、舛形　尚、正木　勉
- Organizer
  第110回日本消化器病学会四国支部例会・第121回日本消化器内視鏡学会四国支部例会
- Data Source
  KAKENHI-PROJECT-16K09361
[Presentation] Galectin-9による食道扁平上皮癌のアポトーシスの誘導と作用機序2017
- Author(s)
  千代大翔、藤原新太郎、森下朝洋、藤田浩二、山名佳美、大浦杏子、寒川英里、田所智子、小林伸也、松永多恵、西山典子、綾木麻紀、谷内田達夫、小原英幹、森　宏仁、正木　勉
- Organizer
  第103回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09361
[Presentation] 消化管低悪性度GISTと平滑筋腫のmicroRNAの発現プロフィールの比較～粘膜下トンネル生検法による採取サンプルを用いて～2015
- Author(s)
  藤田浩二，小原英幹
- Organizer
  日本消化器内視鏡学会
- Place of Presentation
  日本、名古屋
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-15K06855
[Presentation] Differences in miRNA expression profiles between GIST and leiomyoma in human samples acquired by submucosal tunneling biopsy.2015
- Author(s)
  Fujita K, Kobara H
- Organizer
  United European Gastroenterology Week 2015
- Place of Presentation
  Spain, barcelona
- Year and Date
  2015-10-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06855

1. Masaki Tsutomu (30335848)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
2. IWAMA Hisakazu (20398035)

# of Collaborated Projects: 6 results

# of Collaborated Products: 7 results
3. 藤田浩二 (50749421)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
4. 森下朝洋 (60423430)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
5. 森宏仁 (20568844)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
6. 大森典子 (50613410)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. 谷丈二 (00596075)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. 野村貴子 (70645415)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 米山弘人 (80294750)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. 千代大翔 (50769346)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. 仁木敏朗 (40558508)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
12. 田所智子 (50813177)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 大浦杏子 (80834639)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 藤原新太郎 (30612486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 坂本鉄平 (30769328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中原麻衣 (00865610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 高橋悟 (50297579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

kobara hideki 小原 英幹

Kobara Hideki 小原 英幹

Research Projects

Research Products

Co-Researchers

内視鏡画像診断に向けた腫瘍の3次元モデル化手法の構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of relevant microRNAs and molecular mechanism for detecting early gastric carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Examination of the effect of combination therapy of galectin-9 and epigallocatechin gallate on hepatocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Anti-tumor effect of Galectin-9 on metastatic hepatocellular carcinoma and its microRNA basis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Antitumor effects of lifestyle drugs on colorectal cancer: Involvement of antihypertensive drug ARB as a novel chemopreventive agentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic study on treatment of hepatocellular carcinoma targetted of Gal-9 exosomes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of pathway and prognostic factor prediction derived from microRNA analysis in gastrointestinal submucosal tumorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Antihypertensive drug telmisartan inhibits cell proliferation of gastrointestinal stromal tumor cells in?vitro2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Galectin-9 Induces Mitochondria-Mediated Apoptosis of Esophageal Cancer In Vitro and In Vivo in a Xenograft Mouse Model.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Therapeutic potential of the antidiabetic drug metformin in small bowel adenocarcinoma.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] icroRNA profile of hepatic epithelioid hemangioendothelioma: A case report.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of submucosal tunneling biopsy versus EUS-guided FNA for gastric subepithelial lesions: a prospective study with crossover design2017

Author(s)

Journal Title

kobara hideki 小原英幹

Kobara Hideki 小原英幹