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Shimazu Tadahiro  島津 忠広

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Researcher Number 10618771
Other IDs
Affiliation (Current) 2025: 国立研究開発法人理化学研究所, 開拓研究所, 専任研究員
Affiliation (based on the past Project Information) *help 2020 – 2024: 国立研究開発法人理化学研究所, 開拓研究本部, 専任研究員
2017: 国立研究開発法人理化学研究所, 主任研究員研究室等, 専任研究員
2016 – 2017: 国立研究開発法人理化学研究所, 眞貝細胞記憶研究室, 専任研究員
2015: 国立研究開発法人理化学研究所, 眞貝細胞記憶研究室, 研究員
Review Section/Research Field
Principal Investigator
Transformative Research Areas, Section (II) / Basic Section 43010:Molecular biology-related / Medical genome science
Except Principal Investigator
Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Transformative Research Areas, Section (II) / Chemical biology
Keywords
Principal Investigator
翻訳後修飾 / メチル化 / ケミカルバイオロジー / SAM / メチル化修飾 / 人工翻訳後修飾 / neo-PTMs / 癌 / タンパク質翻訳後修飾
Except Principal Investigator
翻訳後修飾 … More / プロテオーム / 阻害剤 / タンパク質メチル化 / S-アデノシルメチオニン / プロテオーム解析 / ケミカルバイオロジー / 酵素 / 人工修飾 / 環境応答 / 触媒 / 人工翻訳後修飾 / 細胞内化学 / 検出プローブ / エピゲノム Less
  • Research Projects

    (6 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (4 People)
  •  Analysis on biological function of neo-PTMsPrincipal Investigator

    • Principal Investigator
      島津 忠広
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      Institute of Physical and Chemical Research
  •  neo-PTMs: Cellular chemical networks created by non-canonical post-translational modifications

    • Principal Investigator
      山次 健三
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      Chiba University
  •  Dynamic chemical control of protein methylation

    • Principal Investigator
      五月女 宜裕
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
    • Research Institution
      Ritsumeikan University
      Institute of Physical and Chemical Research
  •  Role of protein histidine methylationPrincipal Investigator

    • Principal Investigator
      Shimazu Tadahiro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43010:Molecular biology-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Role of Histidine methylation by METTL9Principal Investigator

    • Principal Investigator
      Shimazu Tadahiro
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical genome science
    • Research Institution
      Institute of Physical and Chemical Research
  •  Development of the chemical detectors and inhibitors for protein methylation toward chemical epigenomics

    • Principal Investigator
      Sohtome Yoshihiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Chemical biology
    • Research Institution
      Institute of Physical and Chemical Research

All 2023 2022 2021 2017 2016 2015

All Journal Article Presentation Book

  • [Book] 実験医学別冊 エピジェネティクス実験スタンダード: もう悩まない!ゲノム機能制御の読み解き方/メチル化酵素の新規標的分子の網羅的解析2017

    • Author(s)
      島津忠広、五月女宜裕、袖岡幹子、眞貝洋一
    • Total Pages
      398
    • Publisher
      羊土社
    • ISBN
      475810199X
    • Data Source
      KAKENHI-PROJECT-15K12761
  • [Journal Article] Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism2023

    • Author(s)
      Shimazu Tadahiro、Yoshimoto Rei、Kotoshiba Kaoru、Suzuki Takehiro、Matoba Shogo、Hirose Michiko、Akakabe Mai、Sohtome Yoshihiro、Sodeoka Mikiko、Ogura Atsuo、Dohmae Naoshi、Shinkai Yoichi
    • Journal Title

      Genes & Development

      Volume: 37 Issue: 15-16 Pages: 724-742

    • DOI

      10.1101/gad.350755.123

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K05565, KAKENHI-ORGANIZER-19H05749, KAKENHI-PLANNED-19H05758, KAKENHI-ORGANIZER-22H05017, KAKENHI-PLANNED-22H05020, KAKENHI-PROJECT-23K20298
  • [Journal Article] METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance2022

    • Author(s)
      Matsuura-Suzuki Eriko、Shimazu Tadahiro、Takahashi Mari、Kotoshiba Kaoru、Suzuki Takehiro、Kashiwagi Kazuhiro、Sohtome Yoshihiro、Akakabe Mai、Sodeoka Mikiko、Dohmae Naoshi、Ito Takuhiro、Shinkai Yoichi、Iwasaki Shintaro
    • Journal Title

      eLife

      Volume: 11 Pages: 1-33

    • DOI

      10.7554/elife.72780

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-21H05281, KAKENHI-PLANNED-22H05019, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20K06497, KAKENHI-PROJECT-21K06026, KAKENHI-PLANNED-18H05530, KAKENHI-PROJECT-23K23481, KAKENHI-ORGANIZER-22H05017
  • [Presentation] neo-PTMsプローブが明らかにしたタンパク質ヒスチジン残基メチル化修飾2023

    • Author(s)
      島津 忠広
    • Organizer
      第96回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PLANNED-22H05020
  • [Presentation] Molecular biological analysis of protein histidine methyltransferase in skeletal muscle2023

    • Author(s)
      五輪 愛未, 島津 忠広, 眞貝 洋一
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-ORGANIZER-22H05017
  • [Presentation] タンパク質ヒスチジン残基メチル化修飾によるスプライシング制御2023

    • Author(s)
      島津 忠広, 芳本 玲, 鈴木 健裕, 赤壁 麻衣, 五月女 宜裕, 袖岡 幹, 堂前 直、眞貝 洋一
    • Organizer
      第16回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-ORGANIZER-22H05017
  • [Presentation] タンパク質ヒスチジン残基メチル化修飾によるスプライシング制御2023

    • Author(s)
      島津 忠広, 芳本 玲, 鈴木 健裕, 赤壁 麻衣, 五月女 宜裕, 袖岡 幹, 堂前 直、眞貝 洋一
    • Organizer
      第16回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PLANNED-22H05020
  • [Presentation] neo-PTMsプローブを用いたタンパク質ヒスチジン残基メチル化酵素の発見とその機能解析2023

    • Author(s)
      島津忠広
    • Organizer
      日本薬学会第143年会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-22H05017
  • [Presentation] 合成コファクターが明らかにしたタンパク質His残基メチル化修飾2023

    • Author(s)
      島津忠広
    • Organizer
      第23回日本蛋白質科学会年会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-22H05017
  • [Presentation] neo-PTMsプローブが明らかにしたタンパク質ヒスチジン残基メチル化修飾2023

    • Author(s)
      島津忠広
    • Organizer
      第96回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-22H05017
  • [Presentation] Molecular biological analysis of protein histidine methyltransferase in skeletal muscle2023

    • Author(s)
      五輪 愛未, 島津 忠広, 眞貝 洋一
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-PLANNED-22H05020
  • [Presentation] 合成コファクターが明らかにしたタンパク質His残基メチル化修飾2023

    • Author(s)
      島津 忠広
    • Organizer
      第23回日本蛋白質科学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-22H05020
  • [Presentation] タンパク質His残基メチル化修飾の生理機能2023

    • Author(s)
      島津 忠広
    • Organizer
      第46回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-22H05020
  • [Presentation] neo-PTMsプローブを用いたタンパク質ヒスチジン残基メチル化酵素の発見とその機能解析2023

    • Author(s)
      島津忠広
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PLANNED-22H05020
  • [Presentation] タンパク質His残基メチル化修飾の生理機能2023

    • Author(s)
      島津忠広
    • Organizer
      第46回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-22H05017
  • [Presentation] Biochemical analysis of protein histidine methylation2022

    • Author(s)
      渡邊 優衣, 島津忠広, 眞貝洋一
    • Organizer
      第95回日本生化学会大会
    • Data Source
      KAKENHI-ORGANIZER-22H05017
  • [Presentation] タンパク質ヒスチジンπ型メチル化酵素欠損マウスは胎生致死になる2022

    • Author(s)
      島津忠広
    • Organizer
      第15回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PROJECT-20K06497
  • [Presentation] タンパク質ヒスチジンπ型メチル化酵素欠損マウスは胎生致死になる2022

    • Author(s)
      島津 忠広、芳本 玲、事柴 芳、鈴木 健裕、赤壁 麻衣、五月女 宜裕、袖岡 幹子、堂前 直、眞貝 洋一
    • Organizer
      第15回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-ORGANIZER-22H05017
  • [Presentation] METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance2022

    • Author(s)
      Matsuura-Suzuki Eriko, Shimazu Tadahiro, Takahashi Mari, Kotoshiba Kaoru, Suzuki Takehiro, Kashiwagi Kazuhiro, Sohtome Yoshihiro, Akakabe Mai, Sodeoka Mikiko, Dohmae Naoshi, Ito Takuhiro, Shinkai Yoichi, Iwasaki Shintaro
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-ORGANIZER-22H05017
  • [Presentation] タンパク質ヒスチジン残基メチル化酵素の分子機構とその役割2022

    • Author(s)
      島津忠広
    • Organizer
      第435回熊本大学発生研セミナー
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-22H05017
  • [Presentation] METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance2022

    • Author(s)
      Matsuura-Suzuki Eriko, Shimazu Tadahiro, Takahashi Mari, Kotoshiba Kaoru, Suzuki Takehiro, Kashiwagi Kazuhiro, Sohtome Yoshihiro, Akakabe Mai, Sodeoka Mikiko, Dohmae Naoshi, Ito Takuhiro, Shinkai Yoichi, Iwasaki Shintaro
    • Organizer
      RNA Biology, Cold Spring Harbor Asia (CSHA)
    • Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-22H05017
  • [Presentation] タンパク質ヒスチジンπ-メチル化酵素METTL9の機能解析2021

    • Author(s)
      島津 忠広、鈴木 健裕、赤壁 麻衣、五月女 宜裕、 袖岡 幹子、堂前 直、 眞貝 洋一
    • Organizer
      第14回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PROJECT-20K06497
  • [Presentation] ProSeAMを用いるケミカルメチローム解析及びタンパク質メチル化阻害剤探索2017

    • Author(s)
      五月女宜裕、島津忠広、Barjau Joaquin、藤城信哉、赤壁麻依、寺山直樹、どど孝介、伊藤昭博、吉田稔、眞貝洋一、袖岡幹子
    • Organizer
      日本ケミカルバイオロジー学会 第12回年会
    • Data Source
      KAKENHI-PROJECT-15K12761
  • [Presentation] Synthesis of selenium-based S-adenocylmethionine analogs2017

    • Author(s)
      Mai Akakabe, Yoshihiro Sohtome, Naoki Terayama, Tadahiro Shimazu, Yoichi, Shinkai, Mikiko Sodeoka
    • Organizer
      RIKEN Epigenetics in Tsukuba
    • Place of Presentation
      RIKEN Tsukuba (Tsukuba, Ibaraki)
    • Year and Date
      2017-02-16
    • Data Source
      KAKENHI-PROJECT-15K12761
  • [Presentation] Uncovering protein methylation with a selenium based S-adenosyl-methionine analog2016

    • Author(s)
      Tadahiro Shimazu, Barjau Joaquin, Yoshihiro Sohtome, Mikiko Sodeoka, Yoichi Shinkai
    • Organizer
      International Symposium for RIKENEpigenetics Program 2016
    • Place of Presentation
      埼玉県・和光市
    • Year and Date
      2016-02-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K12761
  • [Presentation] Exploring nonhistone lysine methylation with a selenium based S-adenosyl-methionine analogue2015

    • Author(s)
      Tadahiro Shimazu, Barjau Joaquin, Yoshihiro Sohtome, Mikiko Sodeoka, Yoichi Shinkai
    • Organizer
      第40回内藤コンファレス
    • Place of Presentation
      北海道・札幌市
    • Year and Date
      2015-09-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K12761
  • [Presentation] Exploring chemical strategies to control and analyze protein methylations2015

    • Author(s)
      Yoshihiro Sohtome, Joaquin Barjau, Shinya Fujishiro, Kosuke Dodo, Akihiro Ito, Minoru Yoshida, Tadahiro Shimazu, Yoichi Shinkai and Mikiko Sodeoka
    • Organizer
      Frontiers in Chromatin Biology and Chemical Epigenetics/Epigenomics, PacifiChem 2015
    • Place of Presentation
      Honolulu (USA)
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K12761
  • 1.  Sohtome Yoshihiro (50431888)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 2.  山次 健三 (30646807)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  ITO Takuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  YOSHIMOTO Rei
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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