• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

KANO YOSHIHITO  加納 嘉人

… Alternative Names

Kano Yoshihito  加納 嘉人

Less
Researcher Number 10633125
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-7511-7009
Affiliation (Current) 2025: 東京科学大学, 大学院医歯学総合研究科, 講師
Affiliation (based on the past Project Information) *help 2021 – 2023: 東京医科歯科大学, 大学院医歯学総合研究科, 講師
2019 – 2021: 東京医科歯科大学, 大学院医歯学総合研究科, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 56050:Otorhinolaryngology-related / 0901:Oncology and related fields
Except Principal Investigator
Basic Section 57060:Surgical dentistry-related
Keywords
Principal Investigator
クリニカルシークエンス / RAS-MAPK経路 / 免疫チェックポイント阻害剤 / RAS標的治療 / 薬物治療 / がんゲノム医療 / オルガノイド / RASシグナル / 免疫療法 / 頭頸部癌 … More / がん個別化医療 / 分子標的治療 / SHP2 / 膵臓癌 / リキッドバイオプシー / チロシンリン酸化 / Q61変異 / SHP2阻害 / KRAS … More
Except Principal Investigator
腫瘍環境 / プレシジョンメディシン / がんゲノム / がんゲノム医療 / 多発癌 / 口腔癌 / 遺伝子変異 / ゲノム検査 Less
  • Research Projects

    (3 results)
  • Research Products

    (40 results)
  • Co-Researchers

    (10 People)
  •  新規RASシグナル阻害剤の頭頸部癌治療応答基盤解明Principal Investigator

    • Principal Investigator
      加納 嘉人
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Analysis of specific gene mutations in multiple oral cancer cases using genomic test.

    • Principal Investigator
      平井 秀明
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Niigata University
      Tokyo Medical and Dental University
  •  Molecular and clinical characterization of sensivity to SHP2 inhibition in KRAS-mutant cancersPrincipal Investigator

    • Principal Investigator
      Kano Yoshihito
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0901:Oncology and related fields
    • Research Institution
      Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020 2019 Other

All Journal Article Presentation Other

  • [Journal Article] Chemotherapy and COVID-19 Vaccination in Patients With Gastrointestinal Cancer2024

    • Author(s)
      SUENAGA MITSUKUNI、YAMAUCHI SHINICHI、MORIKAWA RYO、NOJI RIKA、KANO YOSHIHITO、TOKUNAGA MASANORI、KINUGASA YUSUKE
    • Journal Title

      In Vivo

      Volume: 38 Issue: 3 Pages: 1278-1284

    • DOI

      10.21873/invivo.13566

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09680, KAKENHI-PROJECT-21K07235
  • [Journal Article] Clinical Response of Primary Malignant Pericardial Mesothelioma with Peritoneal Dissemination to Nivolumab2024

    • Author(s)
      Fujiwara Shun、Kano Yoshihito、Maejima Yasuhiro、Fujioka Tomoyuki、Tamura Kazuhiro、Kirimura Susumu、Miyake Satoshi、Okamoto Ryuichi
    • Journal Title

      Intern. Med.

      Volume: 63 Issue: 4 Pages: 513-519

    • DOI

      10.2169/internalmedicine.1707-23

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2024-02-15
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09680
  • [Journal Article] Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines2024

    • Author(s)
      Ogasawara N, Kano Y, Yoneyama Y, Kobayashi S, Watanabe S, Kirino S, Velez-Bravo FD, Hong Y, Ostapiuk A, Lutsik P, Onishi I, Yamauchi S, Hiraguri Y, Ito G, Kinugasa Y, Ohashi K, Watanabe M, Okamoto R, Tejpar S, Yui S.
    • Journal Title

      iScience

      Volume: 27 Issue: 3 Pages: 109247-109247

    • DOI

      10.1016/j.isci.2024.109247

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06923, KAKENHI-PROJECT-22K09680, KAKENHI-PROJECT-23K07394, KAKENHI-PROJECT-21KK0146, KAKENHI-PROJECT-22H00465, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-23K27578
  • [Journal Article] Clinical Utility of Comprehensive Genomic Profiling in Patients with Unresectable Hepatocellular Carcinoma2023

    • Author(s)
      Ishido Shun, Tsuchiya Kaoru, Kano Yoshihito, et. al.
    • Journal Title

      Cancers

      Volume: 15 Issue: 3 Pages: 719-719

    • DOI

      10.3390/cancers15030719

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09680, KAKENHI-PROJECT-21K19476, KAKENHI-PROJECT-23K24315
  • [Journal Article] Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors.2023

    • Author(s)
      Kaneko S, Asahina Y, Nakagawa M, Murakawa M, Miyazaki Y, Asakage T, Fukuda S, Namiki T, Kano Y, Nagata M, Tsuchiya J, Miyoshi M, Kitahata-Kawai F, Nitta S, Itsui Y, Kakinuma S, Okamoto R.
    • Journal Title

      Hepatology Reserch

      Volume: 53 Issue: 5 Pages: 450-459

    • DOI

      10.1111/hepr.13878

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07977, KAKENHI-PROJECT-22K08005, KAKENHI-PROJECT-22K09680, KAKENHI-PROJECT-21K19476, KAKENHI-PROJECT-22K20910, KAKENHI-PROJECT-21H02896, KAKENHI-PROJECT-23K24315, KAKENHI-PROJECT-23K27580
  • [Journal Article] Strategic Insight into the Combination Therapies for Metastatic Colorectal Cancer2023

    • Author(s)
      Kano Yoshihito、Suenaga Mitsukuni、Uetake Hiroyuki
    • Journal Title

      Current Oncology

      Volume: 30 Issue: 7 Pages: 6546-6558

    • DOI

      10.3390/curroncol30070480

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09680, KAKENHI-PROJECT-21K07235
  • [Journal Article] The Efficacy of Immunotherapy and Clinical Utility of Comprehensive Genomic Profiling in Adenoid Cystic Carcinoma of Head and Neck2023

    • Author(s)
      Naito Takahiro、Noji Rika、Kugimoto Takuma、Kuroshima Takeshi、Tomioka Hirofumi、Fujiwara Shun、Suenaga Mitsukuni、Harada Hiroyuki、Kano Yoshihito
    • Journal Title

      Medicina

      Volume: 59 Issue: 12 Pages: 2111-2111

    • DOI

      10.3390/medicina59122111

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09680, KAKENHI-PROJECT-21K07235
  • [Journal Article] 遺伝子検査の基礎知識 ゲノム検査はどんな場合に行うか?臨床医として知っておくべきこと2022

    • Author(s)
      加納嘉人
    • Journal Title

      肝臓クリニカルアップデート

      Volume: 8 Pages: 102-106

    • Data Source
      KAKENHI-PROJECT-22K09680
  • [Journal Article] Comprehensive Genomic Profiling Reveals Clinical Associations in Response to Immune Therapy in Head and Neck Cancer2022

    • Author(s)
      Noji R、Tohyama K、Kugimoto T、Kuroshima T、Hirai H、Tomioka H、Michi Y、Tasaki A、Ohno K、Ariizumi Y、Onishi I、Suenaga M、Mori T、Okamoto R、Yoshimura R、Miura M、Asakage T、Miyake S、Ikeda S、Harada H、Kano Y
    • Journal Title

      Cancers

      Volume: 14 Issue: 14 Pages: 3476-3476

    • DOI

      10.3390/cancers14143476

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07235, KAKENHI-PROJECT-21K10134, KAKENHI-PROJECT-22K09680
  • [Journal Article] MYC-PDL1 axis reduces sensitivity to nivolumab in recurrent head and neck squamous cell carcinoma2022

    • Author(s)
      Noji Rika、Kano Yoshihito、Hirai Hideaki、Onishi Iichiroh、Nishii Naoto、Yoshimura Ryoichi、Miyake Satoshi、Ikeda Sadakatsu、Harada Hiroyuki
    • Journal Title

      Oral Oncology

      Volume: 124 Pages: 105666-105666

    • DOI

      10.1016/j.oraloncology.2021.105666

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23909, KAKENHI-PROJECT-21K10134
  • [Journal Article] リキッドバイオプシーがもたらすがん診療の変革2022

    • Author(s)
      加納嘉人
    • Journal Title

      消化器・肝臓内科

      Volume: 11 Pages: 479-482

    • Data Source
      KAKENHI-PROJECT-22K09680
  • [Journal Article] Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study2022

    • Author(s)
      Aoyagi Yasuko、Kano Yoshihito et.al
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 3 Pages: 0266112-0266112

    • DOI

      10.1371/journal.pone.0266112

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K23909, KAKENHI-PROJECT-22K09680
  • [Journal Article] Primary pulmonary choriocarcinoma with a genomic sequence2021

    • Author(s)
      Onishi Iichiroh、Kirimura Susumu、Wakejima Ryo、Okubo Kenichi、Odai Tamami、Kakuta Ryota、Kano Yoshihito、Ikeda Sadakatsu、Akashi Takumi、Kitagawa Masanobu
    • Journal Title

      Pathology International

      Volume: 72 Issue: 2 Pages: 141-143

    • DOI

      10.1111/pin.13193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Journal Article] ASO Author Reflections: Impact of Liquid Biopsy Using Plasma Cell-Free DNA in Solid Tumors in Japan2021

    • Author(s)
      Matsudera Shotaro、Kano Yoshihito、Ikeda Sadakatsu
    • Journal Title

      Annals of Surgical Oncology

      Volume: 28 Issue: 13 Pages: 8506-8507

    • DOI

      10.1245/s10434-021-09858-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Journal Article] A Pilot Study Analyzing the Clinical Utility of Comprehensive Genomic Profiling Using Plasma Cell-Free DNA for Solid Tumor Patients in Japan (PROFILE Study)2021

    • Author(s)
      Matsudera S、Kano Y、Aoyagi Y、Tohyama K、Takahashi K、Kumaki Y、Mitsumura T、Kimura K、Onishi I、Takemoto A、Ban D、Ono H、Kudo Atsushi、et.al.
    • Journal Title

      Annals of Surgical Oncology

      Volume: - Issue: 13 Pages: 697-706

    • DOI

      10.1245/s10434-021-09856-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09041, KAKENHI-PROJECT-19K23909
  • [Journal Article] PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells2021

    • Author(s)
      Liotti Federica、Kumar Narender、Prevete Nella、Marotta Maria、Sorriento Daniela、Ieran? Caterina、Ronchi Andrea、Marino Federica Zito、Moretti Sonia、Colella Renato、Puxeddu Efiso、Paladino Simona、Kano Yoshihito、Ohh Michael、Scala Stefania、Melillo Rosa Marina
    • Journal Title

      Journal of Experimental & Clinical Cancer Research

      Volume: 40 Issue: 1 Pages: 22-22

    • DOI

      10.1186/s13046-020-01818-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Journal Article] The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors2021

    • Author(s)
      Gebregiworgis Teklab, Kano Yoshihito et. al
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1

    • DOI

      10.1038/s41467-021-26526-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Journal Article] NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS-MAPK Pathway in Neuroblastoma2020

    • Author(s)
      Valencia-Sama Ivette、Ladumor Yagnesh、Kee Lynn、Adderley Teresa、Christopher Gabriella、Robinson Claire M.、Kano Yoshihito、Ohh Michael、Irwin Meredith S.
    • Journal Title

      Cancer Research

      Volume: 80 Issue: 16 Pages: 3413-3423

    • DOI

      10.1158/0008-5472.can-19-3822

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] 舌扁平上皮癌におけるPD-1免疫チェックポイント阻害剤投与症例の免疫プロファイリング解析2023

    • Author(s)
      大内崚、ダルンパン ピサッチャー、野地理夏、加納嘉人、西井直人、野口誠、濱垣美和子、池田通、原田浩之、東みゆき
    • Organizer
      第77回日本口腔科学会
    • Data Source
      KAKENHI-PROJECT-22K09680
  • [Presentation] 頭頸部腺様嚢胞癌における免疫療法の有効性と包括的ゲノムプロファイリングの臨床的解析2023

    • Author(s)
      内藤喬浩, 藤原 俊, 野地理夏, 釘本琢磨, 黒嶋雄志, 富岡寛文, 末永光邦, 原田浩之, 加納嘉人
    • Organizer
      第42回日本口腔腫瘍学会総会
    • Data Source
      KAKENHI-PROJECT-22K09680
  • [Presentation] 頭頸部癌免疫療法におけるリキッドバイオプシーモニタリングの有用性の検討2022

    • Author(s)
      野地理夏,工藤 亮,角田龍太,及川 悠,大迫利光,釘本琢磨,黒嶋雄志,平井秀明,島本裕彰,富岡寛文,道 泰之,三宅 智,池田貞勝,原田浩之,加納嘉人
    • Organizer
      第46回日本頭頸部癌学会
    • Data Source
      KAKENHI-PROJECT-21K10134
  • [Presentation] Clinical Utility of Comprehensive Genomic Profiling in Advanced Liver Cancers2022

    • Author(s)
      Yoshihito Kano
    • Organizer
      APASL Oncology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K09680
  • [Presentation] 頭頸部癌免疫療法におけるリキッドバイオプシーモニタリングの有用性の検討2022

    • Author(s)
      野地理夏,加納嘉人
    • Organizer
      第46回日本頭頸部癌学会
    • Data Source
      KAKENHI-PROJECT-22K09680
  • [Presentation] 進行肝癌に対するがんゲノム診療における臨床的問題点とリアルワールドデータ解析2022

    • Author(s)
      加納嘉人
    • Organizer
      第108回 日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-22K09680
  • [Presentation] Monitoring for Immunotherapy in Head and Neck Cancer by Liquid Biopsy2022

    • Author(s)
      Rika Noji, Yoshihito Kano
    • Organizer
      第20回日本臨床腫瘍学会
    • Data Source
      KAKENHI-PROJECT-22K09680
  • [Presentation] がんゲノムビッグデータと頭頸部癌最新薬物治療2022

    • Author(s)
      加納嘉人
    • Organizer
      第198回御茶ノ水耳鼻咽喉・頭頸科治療研究会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K09680
  • [Presentation] がんゲノム解析によりニボルマブ耐性機構が示唆された再発頬粘膜癌の一例2021

    • Author(s)
      野地理夏,加納嘉人,平井秀明,山下大和,工藤亮,富岡寛文,島本裕彰,道泰之,大西威一郎,三浦雅彦,吉村亮一,三宅智,池田貞勝,原田浩之
    • Organizer
      第45回日本頭頸部癌学会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] 進行肝癌に対するがんゲノム診療における臨床的問題点とリアルワールドデータ解析2021

    • Author(s)
      加納嘉人、朝比奈靖浩、岡本隆一
    • Organizer
      第108回 日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] がんゲノム解析によりニボルマブ耐性機構が示唆された再発頬粘膜癌の一例2021

    • Author(s)
      野地理夏,加納嘉人,平井秀明,山下大知,工藤 亮,富岡寛文,島本裕彰,道 泰之,大西威一郎,三浦雅彦,吉村亮一,三宅 智,池田貞勝,原田浩之
    • Organizer
      第45回日本頭頸部癌学会
    • Data Source
      KAKENHI-PROJECT-21K10134
  • [Presentation] 肝内胆管癌の臨床的問題点と網羅的がんゲノム解析の有用性検討2021

    • Author(s)
      加納嘉人、北畑富貴子、村川美也子、柿沼晴、東正新、中川美奈、 井津井康浩、新田沙由梨、三好正人、田邉稔、三宅智、池田貞勝、 岡本隆一、朝比奈靖浩
    • Organizer
      第57回肝癌研究会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] 進行肝細胞癌に対するがんゲノム診療における網羅的遺伝子パネル検査の有用性とバイオマーカー探索.2020

    • Author(s)
      加納嘉人、北畑富貴子、村川美也子、柿沼晴、東正新、中川美奈、 井津井康浩、新田沙由梨、三好正人、青柳康子、松寺翔太郎、遠山皓基、 田邉稔、三宅智、池田貞勝、朝比奈靖浩.
    • Organizer
      第56回日本肝癌研究会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] Detection of RAS mutation in solid cancers using NGS-based genome profiling tests.2020

    • Author(s)
      加納嘉人、野地理夏、山下大和、工藤亮、大西威一郎、谷本幸介、宮冬樹、中川剛士、石川敏昭、植竹宏之、絹笠祐介、田邉稔、朝蔭孝宏、原田浩之、岡本隆一、三宅智、池田貞勝
    • Organizer
      第18回日本臨床腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] Clinical utility of tumor-profiling multiplex gene panel testing in advanced head and neck cancer at TMDU.2020

    • Author(s)
      加納 嘉人,野地 理夏, 山下 大和, 工藤 亮, 田崎 彰久, 大野 十央, 有泉 陽介, 平井 秀明, 富岡 寛文, 島本 裕彰, 道 泰之, 三浦 雅彦, 吉村 亮一, 朝蔭 孝宏, 原田 浩之, 岡本 隆一, 三宅 智, 池田 貞勝
    • Organizer
      第18回日本臨床腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] Evasion of KRASQ61H regulation by tyrosine phosphorylation renders cancer cells resistant to SHP2 inhibitor.2020

    • Author(s)
      Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall, Mitsuhiko Ikura, Michael Ohh.
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] KRAS Q61H mutation evades the regulation of tyrosyl phosphorylation and renders cancer cells resistant to SHP2 inhibitor.2020

    • Author(s)
      YOSHIHITO KANO, Teklab Gebregiworgis, Christopher Marshall, Mitsuhiko Ikura, Satoshi Miyake, Michael Ohh.
    • Organizer
      第18回日本臨床腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] Inhibition of SHP2 promotes the tyrosyl phosphorylation of KRAS and suppresses the pancreatic cancer growth.2019

    • Author(s)
      Yoshihito Kano, Teklab Gebregiworgis, Christopher Marshall,Mitsuhiko Ikura, Michael Ohh
    • Organizer
      第78回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] Drugging the Undruggable ~新規分子標的治療による難治癌克服への挑戦~.2019

    • Author(s)
      加納嘉人
    • Organizer
      第25回東京西部消化器先端医療勉強会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] チロシンリン酸化モデルに基づくKRAS制御機構の解明と治療応用の可能性.2019

    • Author(s)
      加納嘉人
    • Organizer
      大阪大学蛋白質研究所セミナー「がん研究の新機軸」
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K23909
  • [Presentation] KRASチロシンリン酸化モデルに基づく膵癌新規分子機構と治療戦略2019

    • Author(s)
      加納嘉人,Teklab Gebregiworgis, Christopher Marshall, 伊倉 光彦, Michael Ohh.
    • Organizer
      第17回日本臨床腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K23909
  • []

  • 1.  原田 浩之 (40343149)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 2.  平井 秀明 (60598895)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  朝蔭 孝宏 (50361481)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  岡本 隆一 (50451935)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  ASAHINA Yasuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  柿沼 晴
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  村川 美也子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  末永 光邦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  工藤 篤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  米山 鷹介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi