Sato Yusuke 佐藤悠介

… Alternative Names

SATO Yusuke 佐藤悠介

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Researcher Number	10735624
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 北海道大学, 薬学研究院, 助教 2014 – 2015: 北海道大学, 薬学研究科(研究院), 特任助教 2014: 北海道大学, 大学院薬学研究院, 特任助教
Review Section/Research Field	Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 90120:Biomaterials-related / Physical pharmacy / Biomedical engineering/Biomaterial science and engineering / Medical pharmacy Except Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 53010:Gastroenterology-related / Broad Section D / Drug development chemistry
Keywords	Principal Investigator 脂質ナノ粒子 / siRNA / RNP / マイクロ流体デバイス / ゲノム編集 / 粒子径 / 核酸送達 / 脳標的 / 核酸 / エンジニアリング … More / 好中球 / 組織浸透 / がん治療 / 粒径制御 / 遺伝子ノックダウン / 足場構造 / RNA送達 / In vivoゲノム編集 / タンパク質送達 / 安全治療域 / ph感受性カチオン性脂質 / 肝疾患治療 / pH感受性カチオン性脂質 / RNP送達 / in vivoゲノム編集 / 粒径 / 薬物送達 / 動態制御 / がん浸透性 / デリバリー / PEG / 細胞内動態 / 体内動態 / pH応答性 / 脂質ナノキャリア … More Except Principal Investigator LNP / 核酸医薬 / 脂質ナノ粒子 / がん免疫療法 / ナノDDS / ミトコンドリア / ナノ医療 / DDS / ライソゾーム / オートファジー / 非アルコール性脂肪性肝炎（NASH） / NK細胞 / 薬物送達学 / 腫瘍血管 / mRNA / スマートポリマー / 高分子ナノ粒子 / 開環交互共重合 / 精密重合 / ドラッグデリバリーシステム / 肝臓線維化 / miRNA / HCV / MEND / miR-6133-5p / TGFβ / TLL1 / 肝線維化 / ナノＤＤＳ / 核酸送達 / 細胞内局在 / siRNA / ミトコンドリア遺伝子治療 / 細胞内動態制御 / 核酸ナノ医療 / ナノ医薬品 / ゲノム編集 / がん免疫 / 律速段階 / 遺伝子治療 / ホスホジエステル結合 / ホスホロチオエート結合 / shRNA / アンチマイクロRNA / 2'-OMe-4'-チオリポヌクレオシド / 核酸創薬 / stat3 / DNMT1 / SPAAC / ヌクレアーゼ抵抗性 / オリゴヌクレオチド / PSMA / 組織標的化 Less

ナノDDSによる生体内機能強化NK細胞の創出と新規がん免疫療法基盤の構築
- Principal Investigator
  
  中村孝司
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Nucleic acid-loaded lipid nanoparticles enabling in vivo engineering of neutrophilsPrincipal Investigator
- Principal Investigator
  
  佐藤悠介
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Activated mRNA delivery system based on core-shell structured LNP with smart polymers
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section D
- Research Institution
  Hokkaido University
全身投与型Cas9 RNP搭載脂質ナノ粒子製剤による脳でのゲノム編集Principal Investigator
- Principal Investigator
  
  佐藤悠介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Hokkaido University
Drug discovery research targeting the lysosomal nutrient sensing mechanism for the prevention of NASH-related liver cancer
- Principal Investigator
  
  田中靖人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kumamoto University
Strategic creation of polymer-lipid hybrid nanoparticles for tissue-selective nucleic acid delivery
- Principal Investigator
  
  Isono Takuya
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Innovative gene/nucleic acid delivery system based on optimized intracellular trafficking steps
- Principal Investigator
  
  HARASHIMA HIDEYOSHI
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Identification of novel therapeutic target for liver fibrosis and elucidation of the mechanism
- Principal Investigator
  
  Tanaka Yasuhito
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya City University
novel cancer treatment by highly permeable small-sized siRNA-loaded lipid nanoparticlesPrincipal Investigator
- Principal Investigator
  
  Sato Yusuke
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Development of lipid nanoparicles for treatment of hepatic diseases by in vivo genome editingPrincipal Investigator
- Principal Investigator
  
  Sato Yusuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Development of niucleic delivery system for targeting primary and metametastatic tumorPrincipal Investigator
- Principal Investigator
  
  SATO Yusuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Hokkaido University
肝細胞標的siRNA送達システムの創製：体内動態と細胞内動態の真の両立Principal Investigator
- Principal Investigator
  
  佐藤悠介
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
Targeting of the nuclease-resistant functional oligonucleotides
- Principal Investigator
  
  MATSUDA Akira
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2011

All Journal Article Presentation Book Patent

[Book] Advances in Genetics Volume 88 Nonviral Vectors for Gene Therapy Lipid- and Polymer-based Gene Transfer2014
- Author(s)
  Sato Y, Nakamura T, Yamada Y, Akita H, Harashima H.
- Total Pages
  409
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-26893001
[Book] 医薬ジャーナル　2014年7月号(Vol.50 No.7)2014
- Author(s)
  佐藤悠介・中村孝司・山田勇磨・原島秀吉
- Total Pages
  200
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-26893001
[Journal Article] Activation of Mitochondrial Oxygen Consumption Rate by Delivering Coenzyme Q10 to Mitochondria of Rat Skeletal Muscle Cell (L6)2024
- Author(s)
  Sato Itsumi、Hibino Mitsue、Takeda Atsuhito、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: - Issue: 7 Pages: 1836-1843
- DOI
  10.1016/j.xphs.2024.01.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-23H00541
[Journal Article] Poly(ethylene Glycol) (PEG)?OligoRNA Hybridization to mRNA Enables Fine‐Tuned Polyplex PEGylation for Spleen‐Targeted mRNA Delivery2024
- Author(s)
  Suzuki Miki、Mochida Yuki、Hori Mao、Hayashi Akimasa、Toh Kazuko、Tockary Theofilus A.、Liu Xueying、Marx Victor、Yokoo Hidetomo、Miyata Kanjiro、Oba Makoto、Uchida Satoshi
- Journal Title
  
  Small Science
  
  Volume: - Issue: 4 Pages: 202300258-202300258
- DOI
  10.1002/smsc.202300258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-21H04962
[Journal Article] mRNA vaccine designs for optimal adjuvanticity and delivery2024
- Author(s)
  Mochida Yuki、Uchida Satoshi
- Journal Title
  
  RNA Biology
  
  Volume: 21 Issue: 1 Pages: 1-27
- DOI
  10.1080/15476286.2024.2333123
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-21H04962
[Journal Article] Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery2024
- Author(s)
  Yum Jongmin、Aulia Fadlina、Kamiya Keisuke、Hori Mao、Qiao Nan、Kim Beob Soo、Naito Mitsuru、Ogura Satomi、Nagata Tetsuya、Yokota Takanori、Uchida Satoshi、Obika Satoshi、Kim Hyun Jin、Miyata Kanjiro
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 35 Issue: 2 Pages: 125-131
- DOI
  10.1021/acs.bioconjchem.3c00456
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-21H04962
[Journal Article] Ionizable Polymeric Micelles with Phenylalanine Moieties Enhance Intracellular Delivery of Self-Replicating RNA for Long-Lasting Protein Expression In Vivo2024
- Author(s)
  Mixich Lucas、Boonstra Eger、Masuda Keita、Li Shang-Wei、Nakashima Yuki、Meng Fanlu、Sakata Momoko、Goda Tatsuro、Uchida Satoshi、Cabral Horacio
- Journal Title
  
  Biomacromolecules
  
  Volume: 25 Issue: 2 Pages: 1058-1067
- DOI
  10.1021/acs.biomac.3c01102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-21H04962
[Journal Article] Serum CXCL10 levels at the start of the second course of atezolizumab plus bevacizumab therapy predict therapeutic efficacy in patients with advanced BCLC stage C hepatocellular carcinoma: A multicenter analysis2023
- Author(s)
  Suzuki Takanori、Kimura Yoshihide、Kusakabe Atsunori、Narahara Satoshi、Tokunaga Takayuki、Nagaoka Katsuya、Kuroyanagi Keita、Kawamura Hayato、Kuno Kayoko、Fujiwara Kei、Nojiri Shunsuke、Kataoka Hiromi、Tanaka Yasuhito
- Journal Title
  
  Cancer Medicine
  
  Volume: 13 Issue: 1 Pages: 1-11
- DOI
  10.1002/cam4.6876
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15971, KAKENHI-PROJECT-23K15076, KAKENHI-PROJECT-21K20906, KAKENHI-PROJECT-23K07359, KAKENHI-PROJECT-23K27589
[Journal Article] Oligosarcosine Conjugation of Arginine-Rich Peptides Improves the Intracellular Delivery of Peptide/pDNA Complexes2023
- Author(s)
  Yokoo Hidetomo、Dirisala Anjaneyulu、Uchida Satoshi、Oba Makoto
- Journal Title
  
  ACS Biomaterials Science & Engineering
  
  Volume: 10 Issue: 2 Pages: 890-896
- DOI
  10.1021/acsbiomaterials.3c01542
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K11841, KAKENHI-PROJECT-21K18062, KAKENHI-PROJECT-22K15257, KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-21H04962
[Journal Article] Polyplex designs for improving the stability and safety of RNA therapeutics2023
- Author(s)
  Uchida Satoshi、Lau Chun Yin Jerry、Oba Makoto、Miyata Kanjiro
- Journal Title
  
  Advanced Drug Delivery Reviews
  
  Volume: 199 Pages: 114972-114972
- DOI
  10.1016/j.addr.2023.114972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-21H04962
[Journal Article] Alkali Metal Carboxylates: Simple, Efficient, and Industrial Relevant Catalysts for Controlled Polymer Synthesis2023
- Author(s)
  Li Feng、Suzuki Ryota、Gao Tianle、Xia Xiaochao、Isono Takuya、Satoh Toshifumi
- Journal Title
  
  Bulletin of the Chemical Society of Japan
  
  Volume: 96 Issue: 9 Pages: 1003-1018
- DOI
  10.1246/bcsj.20230149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23KJ0024, KAKENHI-PROJECT-22K19907
[Journal Article] Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment2023
- Author(s)
  Tockary Theofilus A.、Abbasi Saed、Matsui-Masai Miki、Hayashi Akimasa、Yoshinaga Naoto、Boonstra Eger、Wang Zheng、Fukushima Shigeto、Kataoka Kazunori、Uchida Satoshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 29
- DOI
  10.1073/pnas.2214320120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-21H04962
[Journal Article] One-Step Synthesis of Poly(amide ester)-Based Block Copolymers with Defined Phase Separation Behavior2023
- Author(s)
  Gao Tianle、Li Feng、Suzuki Ryota、Li Huan、Yamamoto Takuya、Xia Xiaochao、Isono Takuya、Satoh Toshifumi
- Journal Title
  
  Macromolecules
  
  Volume: 56 Issue: 20 Pages: 8333-8343
- DOI
  10.1021/acs.macromol.3c01305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23KJ0024, KAKENHI-PROJECT-22K19907
[Journal Article] Harnessing Topology and Stereochemistry of Glycidylamine‐Derived Lipid Nanoparticles for in Vivo mRNA Delivery to Immune Cells in Spleen and Their Application for Cancer Vaccination2023
- Author(s)
  Abd Elwakil Mahmoud M.、Suzuki Ryota、Khalifa Alaa M.、Elshami Rania M.、Isono Takuya、Elewa Yaser H.A.、Sato Yusuke、Nakamura Takashi、Satoh Toshifumi、Harashima Hideyoshi
- Journal Title
  
  Advanced Functional Materials
  
  Volume: 33 Issue: 45 Pages: 1-12
- DOI
  10.1002/adfm.202303795
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ0024, KAKENHI-PROJECT-22K19907, KAKENHI-PROJECT-23H05451
[Journal Article] Genetically engineered transfusable platelets using mRNA lipid nanoparticles2023
- Author(s)
  Leung Jerry、Strong Colton、Badior Katherine E.、Robertson Madelaine、Wu Xiaowu、Meledeo Michael A.、Kang Emma、Paul Manoj、Sato Yusuke、Harashima Hideyoshi、Cap Andrew P.、Devine Dana V.、Jan Eric、Cullis Pieter R.、Kastrup Christian J.
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 48
- DOI
  10.1126/sciadv.adi0508
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H05451
[Journal Article] A system that delivers an antioxidant to mitochondria for the treatment of drug-induced liver injury2023
- Author(s)
  Hibino Mitsue、Maeki Masatoshi、Tokeshi Manabu、Ishitsuka Yoichi、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 6961-6961
- DOI
  10.1038/s41598-023-33893-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19928, KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-23H00541
[Journal Article] Self-Folding Macromolecular Drug Carrier for Cancer Imaging and Therapy2023
- Author(s)
  S. Gao, Y. Miura, A. Sumiyoshi, S. Ohno, K. Ogata, T. Nomoto, M. Matsui, Y. Honda, M. Suzuki, M. Iiyama, K. Osada, I. Aoki, N. Nishiyama
- Journal Title
  
  Advanced Science
  
  Volume: 11 Issue: 7 Pages: 2304171-2304171
- DOI
  10.1002/advs.202304171
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18322, KAKENHI-PROJECT-21K19014, KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-22H00581, KAKENHI-PROJECT-23K21857, KAKENHI-PROJECT-23K24177
[Journal Article] Randomized phase I/II study of vascular endothelial growth factor receptor peptide vaccines for patients with hepatocellular carcinoma2023
- Author(s)
  Yoshimaru Yoko、Nagaoka Katsuya、Tanaka Kentaro、Narahara Satoshi、Inada Hiroki、Kurano Sotaro、Tokunaga Takayuki、Iio Etsuko、Watanabe Takehisa、Setoyama Hiroko、Tateyama Masakuni、Yoshida Koji、Tsunoda Takuya、Nakamura Yusuke、Tanaka Motohiko、Sasaki Yutaka、Tanaka Yasuhito
- Journal Title
  
  Hepatology Research
  
  Volume: - Issue: 5 Pages: 451-464
- DOI
  10.1111/hepr.13995
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15971, KAKENHI-PROJECT-22K16023, KAKENHI-PROJECT-23K15076, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-21K15953, KAKENHI-PROJECT-23K27589
[Journal Article] Reprogramming activated hepatic stellate cells by siRNA-loaded nanocarriers reverses liver fibrosis in mice2023
- Author(s)
  Younis Mahmoud A.、Sato Yusuke、Elewa Yaser H.A.、Harashima Hideyoshi
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 361 Pages: 592-603
- DOI
  10.1016/j.jconrel.2023.08.021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H05451
[Journal Article] Synthesis of hyperbranched polyesters via the ring-opening alternating copolymerisation of epoxides with a cyclic anhydride having a carboxyl group2022
- Author(s)
  Suzuki Ryota、Xia Xiaochao、Gao Tianle、Yamamoto Takuya、Tajima Kenji、Isono Takuya、Satoh Toshifumi
- Journal Title
  
  Polymer Chemistry
  
  Volume: 13 Issue: 38 Pages: 5469-5477
- DOI
  10.1039/d2py00571a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19907
[Journal Article] On the size-regulation of RNA-loaded lipid nanoparticles synthesized by microfluidic device2022
- Author(s)
  Okuda Kento、Sato Yusuke、Iwakawa Kazuki、Sasaki Kosuke、Okabe Nana、Maeki Masatoshi、Tokeshi Manabu、Harashima Hideyoshi
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 348 Pages: 648-659
- DOI
  10.1016/j.jconrel.2022.06.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] Polyether/Polythioether Synthesis via Ring-Opening Polymerization of Epoxides and Episulfides Catalyzed by Alkali Metal Carboxylates2022
- Author(s)
  Gao Tianle、Xia Xiaochao、Tajima Kenji、Yamamoto Takuya、Isono Takuya、Satoh Toshifumi
- Journal Title
  
  Macromolecules
  
  Volume: 55 Issue: 21 Pages: 9373-9383
- DOI
  10.1021/acs.macromol.2c00656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19907
[Journal Article] mRNA-Loaded Lipid Nanoparticles Targeting Dendritic Cells for Cancer Immunotherapy2022
- Author(s)
  Sasaki Kosuke、Sato Yusuke、Okuda Kento、Iwakawa Kazuki、Harashima Hideyoshi
- Journal Title
  
  Pharmaceutics
  
  Volume: 14 Issue: 8 Pages: 1572-1572
- DOI
  10.3390/pharmaceutics14081572
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] Combined nano cancer immunotherapy based on immune status in a tumor microenvironment2022
- Author(s)
  Nakamura Takashi、Kawakami Kyoko、Nomura Momoka、Sato Yusuke、Hyodo Mamoru、Hatakeyama Hiroto、Hayakawa Yoshihiro、Harashima Hideyoshi
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 345 Pages: 200-213
- DOI
  10.1016/j.jconrel.2022.03.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03387, KAKENHI-PROJECT-19H01170
[Journal Article] Fine‐tuning the encapsulation of a photosensitizer in nanoparticles reveals the relationship between internal structure and phototherapeutic effects2022
- Author(s)
  Kubota Fumika、Satrialdi、Takano Yuta、Maeki Masatoshi、Tokeshi Manabu、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  Journal of Biophotonics
  
  Volume: 16 Issue: 3
- DOI
  10.1002/jbio.202200119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H04523, KAKENHI-PROJECT-21K19036, KAKENHI-PROJECT-23K21067
[Journal Article] The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines.2021
- Author(s)
  Nakamura T, Nakade T, Yamada K, Sato Y, Harashima H
- Journal Title
  
  Int J Pharm
  
  Volume: 609 Pages: 121140-121140
- DOI
  10.1016/j.ijpharm.2021.121140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H03373
[Journal Article] Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations2021
- Author(s)
  Abbasi S, Higashino H, Sato Y, Minami K, Kataoka M, Yamashita S, Harashima H
- Journal Title
  
  Mol Pharm
  
  Volume: 18 Issue: 9 Pages: 3181-3189
- DOI
  10.1021/acs.molpharmaceut.1c00197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation.2021
- Author(s)
  Nakamura T, Sato T, Endo R, Sasaki S, Takahashi N, Sato Y, Hyodo M, Hayakawa Y, Harashima H.
- Journal Title
  
  J Immunotherapy Cancer
  
  Volume: 9 Issue: 7 Pages: e002852-e002852
- DOI
  10.1136/jitc-2021-002852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H03373
[Journal Article] Engineered e-decalactone lipomers by-pass the liver to selectively in vivo deliver mRNA to the lungs without targeting ligands2021
- Author(s)
  Elwakil A, Gao T, Isono T, Sato Y, Elewa Y, Satoh T, Harashima H,
- Journal Title
  
  Mater Horizons
  
  Volume: 8 Issue: 8 Pages: 2251-2259
- DOI
  10.1039/d1mh00185j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20J20737
[Journal Article] Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles2020
- Author(s)
  Sato Y, Okabe N, Note Y, Hashiba K, Maeki M, Tokeshi M, Harashima H
- Journal Title
  
  Acta Biomaterialia
  
  Volume: 102 Pages: 341-350
- DOI
  10.1016/j.actbio.2019.11.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
[Journal Article] Lipid nanoparticles fuse with cell membranes of immune cells at low temperatures leading to the loss of transfection activity2020
- Author(s)
  Nakamura T, Yamada K, Sato Y, Harashima H.
- Journal Title
  
  Int J Pharm.
  
  Volume: 587 Pages: 119652-119652
- DOI
  10.1016/j.ijpharm.2020.119652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution2020
- Author(s)
  Nakamura Takashi, Kawai Minori, Sato Yusuke, Maeki Masatoshi, Tokeshi Manabu, Harashima Hideyoshi
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 17 Issue: 3 Pages: 944-953
- DOI
  10.1021/acs.molpharmaceut.9b01182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03974, KAKENHI-PROJECT-18K19889, KAKENHI-PROJECT-19H01170
[Journal Article] The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA delivery.2020
- Author(s)
  Hashiba A, Toyooka M, Sato Y, Maeki M, Tokeshi M, Harashima H.
- Journal Title
  
  J Control Release.
  
  Volume: 327 Pages: 467-476
- DOI
  10.1016/j.jconrel.2020.08.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] Inhibitory Effect of a Human MicroRNA, miR-6133-5p, on the Fibrotic Activity of Hepatic Stellate Cells in Culture2020
- Author(s)
  Hamada-Tsutsumi Susumu、Onishi Masaya、Matsuura Kentaro、Isogawa Masanori、Kawashima Keigo、Sato Yusuke、Tanaka Yasuhito
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 19 Pages: 7251-7251
- DOI
  10.3390/ijms21197251
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09435, KAKENHI-PROJECT-20K08313, KAKENHI-PROJECT-20K08314, KAKENHI-PROJECT-20K17028, KAKENHI-PROJECT-19H03640
[Journal Article] A study of the endocytosis mechanism and transendothelial activity of lung-targeted GALA-modified liposomes.2019
- Author(s)
  Santiwarangkool S, Akita H, Khalil IA, Abd Elwakil MM, Sato Y, Kusumoto K, Harashima H.
- Journal Title
  
  J Control Release.
  
  Volume: 307 Pages: 55-63
- DOI
  10.1016/j.jconrel.2019.06.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] Recent advances in the targeting of systemically administered non-viral gene delivery systems.2019
- Author(s)
  Khalil IA, Sato Y, Harashima H.
- Journal Title
  
  Expert Opin Drug Deliv.
  
  Volume: 16 Issue: 10 Pages: 1037-1050
- DOI
  10.1080/17425247.2019.1656196
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
[Journal Article] Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo2019
- Author(s)
  Yusuke Sato, Kazuki Hashiba, Kosuke Sasaki, Masatoshi Maeki, Manabu Tokeshi, HIdeyoshi Harashima
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 295 Pages: 140-152
- DOI
  10.1016/j.jconrel.2019.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05052
[Journal Article] Innovative nanotechnologies for enhancing nucleic acids/gene therapy: Controlling intracellular trafficking to targeted biodistribution2019
- Author(s)
  Nakamura Takashi, Yamada Yuma, Sato Yusuke, Khalil A Ikramy, Harashima Hideyoshi
- Journal Title
  
  Biomaterials
  
  Volume: 218 Pages: 119329-119329
- DOI
  10.1016/j.biomaterials.2019.119329
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19888, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-17H03974, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
[Journal Article] Development of the iLiNP Device: Fine Tuning the Lipid Nanoparticle Size within 10 nm for Drug Delivery2018
- Author(s)
  Niko Kimura, Masatoshi Maeki, Yusuke Sato, Yusuke Note, Akihiko Ishida, Hirofumi Tani, Hideyoshi Harashima, Manabu Tokeshi
- Journal Title
  
  ACS Omega
  
  Volume: 3 Issue: 5 Pages: 5044-5041
- DOI
  10.1021/acsomega.8b00341
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05052
[Journal Article] Innovative technologies in Nanomedicines: from passive targeting to active targeting/from controlled pharmacokinetics to controlled intracellular pharmacokinetics.2017
- Author(s)
  Sato Y, Sakurai Y, Kajimoto K, Nakamura T, Yamada Y, Akita H, Harashima H.
- Journal Title
  
  Macromolecular Bioscience
  
  Volume: 17 Issue: 1 Pages: 1-16
- DOI
  10.1002/mabi.201600179
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26282132, KAKENHI-PROJECT-26713002, KAKENHI-PROJECT-26670741, KAKENHI-PROJECT-15K20831, KAKENHI-PROJECT-16K11180
[Journal Article] pH-labile PEGylation of siRNA-loaded lipid nanoparticle improves active targeting and gene silencing activity in hepatocytes2017
- Author(s)
  Hashiba K, Sato Y, Harashima H
- Journal Title
  
  J. Control. Release
  
  Volume: 262 Pages: 239-246
- DOI
  10.1016/j.jconrel.2017.07.046
- NAID
  120006523729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05052
[Journal Article] Sato Y, Matsui H, Yamamoto N, Sato R, Munakata T, Kohara M, Harashima H. Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus2017
- Author(s)
  Sato Y, Matsui H, Yamamoto N, Sato R, Munakata T, Kohara M, Harashima H
- Journal Title
  
  J Control Release
  
  Volume: 266 Pages: 216-225
- DOI
  10.1016/j.jconrel.2017.09.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08871, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-15K19120
[Journal Article] Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers2017
- Author(s)
  Maeki M, Fujishima Y, Sato Y, Yasui T, Kaji N, Ishida A, Tani H, Baba Y, Harashima H, Tokeshi M
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 11 Pages: e0187962-e0187962
- DOI
  10.1371/journal.pone.0187962
- NAID
  120006377541
- Data Source
  KAKENHI-PROJECT-17H05052
[Journal Article] マイクロ流体デバイスによる脂質ナノ粒子作製とDDSへの応用2016
- Author(s)
  真栄城正寿, 佐藤悠介, 原島秀吉, 渡慶次学
- Journal Title
  
  機能材料
  
  Volume: 36 Pages: 15-21
- Data Source
  KAKENHI-PROJECT-15K20831
[Journal Article] Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery2016
- Author(s)
  Yusuke Sato, Yusuke Note, Masatoshi Maeki, Noritada Kaji, Yoshinobu Baba, Manabu Tokeshi, Hideyoshi Harashima
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 229 Pages: 48-57
- DOI
  10.1016/j.jconrel.2016.03.019
- NAID
  120006219995
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K20831
[Journal Article] pH感受性脂質を基盤とした脂質ナノ粒子の開発と核酸ナノメディシンへの応用2016
- Author(s)
  佐藤悠介, 原島秀吉
- Journal Title
  
  化学工業
  
  Volume: 67 Pages: 21-27
- Data Source
  KAKENHI-PROJECT-15K20831
[Journal Article] Development of a multifunctional envelope-type nano device and its application to nanomedicine.2016
- Author(s)
  Sato Y, Nakamura T, Yamada Y, Harashima H.
- Journal Title
  
  J Control Release
  
  Volume: 244 Pages: 194-204
- DOI
  10.1016/j.jconrel.2016.06.042
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26713002, KAKENHI-PROJECT-26670741, KAKENHI-PROJECT-15K20831, KAKENHI-PROJECT-16K11180
[Journal Article] Relationship Between the Physicochemical Properties of Lipid Nanoparticles and the Quality of siRNA Delivery to Liver Cells2016
- Author(s)
  Yusuke Sato, Hiroto Hatakeyama, Mamoru Hyodo, Hideyoshi Harashima
- Journal Title
  
  Molecular Therapy
  
  Volume: 24 Issue: 4 Pages: 788-795
- DOI
  10.1038/mt.2015.222
- NAID
  120005906929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20831, KAKENHI-PROJECT-26830101
[Journal Article] The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus2015
- Author(s)
  Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, Watanabe T, Iijima S, Sakurai Y, Watashi K, Tsutsumi S, Sato Y, Akita H, Wakita T, Rice CM, Harashima H, Kohara M, Tanaka Y, Takaoka A
- Journal Title
  
  Immunity
  
  Volume: 42 Issue: 1 Pages: 123-132
- DOI
  10.1016/j.immuni.2014.12.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390117, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-25253030, KAKENHI-PROJECT-25870015, KAKENHI-PROJECT-25893001, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-26893001
[Journal Article] In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus2014
- Author(s)
  Watanabe T, Hatakeyama H, Matsuda-Yasui C, Sato Y, Sudoh M, Takagi A, Hirata Y, Ohtsuki T, Arai M, Inoue K, Harashima H, Kohara M
- Journal Title
  
  Scientific Reports
  
  Volume: in press Issue: 1 Pages: 4750-4750
- DOI
  10.1038/srep04750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-24390117, KAKENHI-PROJECT-24590988, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-25860305, KAKENHI-PROJECT-26893001
[Journal Article] Selective transcription of an unnatural naphthyridine:imidazopyrimidine base pair containing four hydrogen bonds by using T7 RNA polymerase.2014
- Author(s)
  Nomura, Y.; Kashiwagi, S.; Sato, K.; Matsuda, A.
- Journal Title
  
  Angew. Chem. Int. Ed. Engl.
  
  Volume: 53 Issue: 47 Pages: 12844-12848
- DOI
  10.1002/anie.201406402
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-25410165
[Journal Article] The systemic administration of an anti-miRNA oligonucleotide encapsulaed pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice2014
- Author(s)
  Hiroto Hatakeyama, Manami Murata, Yusuke Sato, Mayumi Takahashi, Noriyuki Minakawa, Akira Matsuda, Hideyoshi Harashima
- Journal Title
  
  J. Control. Release
  
  Volume: 173 Pages: 43-50
- DOI
  10.1016/j.jconrel.2013.10.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-23249008, KAKENHI-PUBLICLY-24107502, KAKENHI-PUBLICLY-24107518
[Journal Article] Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain.2014
- Author(s)
  Tamaru M, Akita H, Nakatani T, Kajimoto K, Sato Y, Hatakeyama H, Harashima H.
- Journal Title
  
  Int J Nanomedicine
  
  Volume: 9 Pages: 4267-4276
- DOI
  10.2147/ijn.s65402
- NAID
  120005476202
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893001
[Journal Article] Multifunctional envelope-type nano device for controlled intracellular trafficking and selective targeting in vivo.2014
- Author(s)
  Kazuaki Kajimoto, Yusuke Sato, Takashi Nakamura, Yuma Yamada, Hidesyoshi Harashima.
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 190 Pages: 593-606
- DOI
  10.1016/j.jconrel.2014.03.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25560219, KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26893001
[Journal Article] An apolipoprotein E modified liposomal nanoparticle : Ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells2014
- Author(s)
  Mina Tamaru, Hidetaka Akita, Kazuaki Kajimoto, Yusuke Sato, Hiroto Hatakeyama, Hideyoshi Harashima
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 465 Issue: 1-2 Pages: 77-82
- DOI
  10.1016/j.ijpharm.2014.02.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-11J05746, KAKENHI-PROJECT-26893001
[Journal Article] Highly Fluorescent 5-(5,6-Dimethoxybenzothiazol-2-yl)-2'-Deoxyuridine 5'-Triphosphate as an Efficient Substrate for DNA Polymerases2011
- Author(s)
  Sato, K.
- Journal Title
  
  ChemBioChem
  
  Volume: 12 Issue: 15 Pages: 2341-2346
- DOI
  10.1002/cbic.201100452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-23750178
[Patent] ミトコンドリアゲノム編集用脂質ナノ粒子2024
- Inventor(s)
  山田勇磨、原島秀吉、佐藤悠介、渡慶次学、真栄城正寿、他
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Overseas
- Data Source
  KAKENHI-PROJECT-23H05451
[Patent] ミトコンドリアゲノム編集用脂質ナノ粒子2023
- Inventor(s)
  山田勇磨、原島秀吉、佐藤悠介、石塚宣、野呂田楓、ほか
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-027872
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] ｐＨ感受性カチオン性脂質及び脂質ナノ粒子2023
- Inventor(s)
  佐藤悠介、伊藤里奈、鈴木裕一、原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-090454
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23H05451
[Patent] 双性イオンリン脂質化合物及びそれを含む脂質ナノ粒子2023
- Inventor(s)
  佐藤悠介、原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-178361
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23H05451
[Patent] 脂質ナノ粒子2022
- Inventor(s)
  佐藤悠介、原島秀吉、小沼はるの
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-060960
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 代謝改善剤2021
- Inventor(s)
  西英一郎、岩﨑広高、大野美紀子、佐藤悠介、原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 脂質ナノ粒子2021
- Inventor(s)
  佐藤悠介、佐々木宏輔、原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-085985
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 脂質ナノ粒子2021
- Inventor(s)
  中村孝司、原島秀吉、佐藤悠介、山田小春、中出泰誠
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-023184
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 溶解剤2021
- Inventor(s)
  原島秀吉、佐藤悠介、アッバシ　サエド　アムジャド　ヨセフ、他
- Industrial Property Rights Holder
  国立大学法人北海道大学、常翔学園
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 脂質ナノ粒子2020
- Inventor(s)
  佐藤悠介、原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 脂質ナノ粒子2019
- Inventor(s)
  佐藤悠介, 原島秀吉, 渡慶次学, 真栄城正寿
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-101203
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17H05052
[Patent] siRNA細胞内送達のための脂質膜構造体2018
- Inventor(s)
  原島秀吉, 佐藤悠介
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-17H05052
[Patent] siRNA細胞内送達のための脂質膜構造体2017
- Inventor(s)
  原島秀吉, 佐藤悠介
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-117708
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17H05052
[Patent] 肝線維化修復剤2015
- Inventor(s)
  中島美紀, 小田祐輝, 原島秀吉, 佐藤悠介
- Industrial Property Rights Holder
  金沢大学, 北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-020308
- Filing Date
  2015-02-04
- Data Source
  KAKENHI-PROJECT-26893001
[Patent] 脂質膜構造体2014
- Inventor(s)
  原島秀吉, 佐藤悠介, など
- Industrial Property Rights Holder
  北海道大学, 公益財団法人東京都医学総合研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-217011
- Filing Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-26893001
[Presentation] 腫瘍血管内皮細胞の機能制御と自然免疫活性化を起点とした新規がん治療法の開発2023
- Author(s)
  上田智貴、中村孝司、遠藤力斗、佐藤悠介、原島秀吉
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] 膜融合性を持つ新規中性リン脂質を用いた効率的なmRNA送達システムの開発2023
- Author(s)
  岩川和樹，佐藤悠介，原島秀吉
- Organizer
  第44回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] An impact of helper lipids on extrahepatic delivery of nucleic acids based on ionizable cationic lipids2023
- Author(s)
  Hideyoshi Harashima, Mahmoud Younis, Seigo Kimura, Yusuke Sato
- Organizer
  Cold Spring Harbor Conferences Asia, The Now and Future of RNA Therapeutics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] 脂質ナノ粒子製剤の粒子径制御と樹状細胞標的化2023
- Author(s)
  佐藤悠介，奥田健斗，佐々木宏輔，岩川和樹，原島秀吉
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] Naked mRNA Jet Injection into the Skin Enables the Robust Vaccination against SARS-CoV-2 in Mice and Cynomolgus Monkeys2023
- Author(s)
  Satoshi Uchida, Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A. Tockary, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka
- Organizer
  11th International mRNA Health Conference
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] 有機触媒を用いた環状酸無水物とオキセタンの開環交互共重合によるポリエステルの合成2023
- Author(s)
  太田伊代香、鈴木涼太、夏小超、高添楽、Li Feng、磯野拓也、佐藤敏文
- Organizer
  第72回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-22K19907
[Presentation] カルボキシ基含有環状酸無水物とエポキシドの開環交互共重合による多分岐ポリエステルの合成2023
- Author(s)
  鈴木涼太、夏小超、高添楽、山本拓矢、田島健次、Li Feng、磯野拓也、佐藤敏文
- Organizer
  第72回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-22K19907
[Presentation] 腫瘍血管破壊を誘導する新機軸がん治療法の開発2023
- Author(s)
  中村孝司、遠藤力斗、上田智貴、佐藤悠介、原島秀吉
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] オキセタンと環状酸無水物の開環交互共重合を駆使したセルフスイッチ重合2023
- Author(s)
  太田伊代香、鈴木涼太、Gao Tianle、Xia Xiaochao、Li Feng、磯野拓也、佐藤敏文
- Organizer
  CSJ化学フェスタ2023
- Data Source
  KAKENHI-PROJECT-22K19907
[Presentation] Extrahepatic delivery of mRNA based on an ionizable cationic lipid library: from hepatocyte to activated stellate cells, from normal to disease state2023
- Author(s)
  Hideyoshi Harashima, Mahmoud Younis, Seigo Kimura, Yusuke Sato
- Organizer
  2nd Annual Next Generation Lipid-Based Nanoparticles Delivery Summit
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] Small and large animal studies of COVID-19 vaccines based on naked mRNA jet-injection2023
- Author(s)
  Satoshi Uchida, Saed Abbasi, Miki Masai, Akimasa Hayashi, Theofilus Tockary, Shiro Akinaga, Kazunori Kataoka
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] マイクロ流体デバイスによる脂質ナノ粒子の粒径制御とin vivo RNA送達2023
- Author(s)
  佐藤悠介、奥田健斗、岩川和樹、佐々木宏輔、原島秀吉
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] 対イオン脂質を用いた効率的なmRNA送達システムの開発2023
- Author(s)
  鈴木裕一，佐藤悠介，原島秀吉
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] 効率的な遺伝子発現を示す新規イオン化脂質の開発2023
- Author(s)
  伊藤里奈，佐藤悠介，原島秀吉
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] 二元系有機触媒を用いた環状エーテル、アジリジン、環状酸無水物の開環共重合における配列制御2023
- Author(s)
  Gao Tianle、Li Feng、磯野拓也、山本拓矢、田島健次、佐藤敏文
- Organizer
  第72回高分子討論会
- Data Source
  KAKENHI-PROJECT-22K19907
[Presentation] Hyperbranched Polyester Synthesis by Ring-opening Alternating Copolymerization of Trimellitic Anhydride with Epoxides2023
- Author(s)
  Ryota Suzuki, Xiaochao Xia, Tianle Gao, Takuya Yamamoto, Kenji Tajima, Feng Li, Takuya Isono, Toshifumi Satoh
- Organizer
  IPC2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19907
[Presentation] Switchable Polymerization: from Complex Monomer Mixtures to Poly(ester amide)-based block copolymers2023
- Author(s)
  Tianle Gao, Xiaochao Xia, Feng Li, Takuya Isono, Toshifumi Satoh
- Organizer
  IPC2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19907
[Presentation] 有機塩基触媒を用いた環状酸無水物とオキセタンの開環交互共重合系の確立2023
- Author(s)
  太田伊代香、鈴木涼太、Gao Tianle、Xia Xiaochao、Li Feng、磯野拓也、佐藤敏文
- Organizer
  2023年度　北海道高分子若手研究会
- Data Source
  KAKENHI-PROJECT-22K19907
[Presentation] Next-generation mRNA vaccines against infectious diseases and cancer2023
- Author(s)
  Satoshi Uchida
- Organizer
  14th Indian Scientists Association in Japan (ISAJ) Annual Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] mRNA vaccine development for infectious disease prevention and cancer treatment2023
- Author(s)
  Satoshi Uchida
- Organizer
  The 18th international Symposium of the institute Network for Biomedical Science
- Invited
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] ナノDDSを基盤とした腫瘍血管破壊を誘導する新規がん治療法の開発2023
- Author(s)
  遠藤力斗、中村孝司、上田智貴、佐藤悠介、原島秀吉
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] 側鎖の構造や置換位置の異なるポリ(ε-カプロラクトン) 誘導体の合成と核酸デリバリー材料への応用2022
- Author(s)
  水上湧太、Mahmoud M. Abd Elwakil、佐藤悠介、磯野拓也、山本拓矢、田島健次、原島秀吉、佐藤敏文
- Organizer
  第12回CSJ化学フェスタ
- Data Source
  KAKENHI-PROJECT-22K19907
[Presentation] ポリ(ε-カプロラクトン) 誘導体を構成成分とする脂質ナノ粒子による肺・脾臓選択的mRNAデリバリー2022
- Author(s)
  水上湧太、Mahmoud M. Abd Elwakil、佐藤悠介、磯野拓也、山本拓矢、田島健次、原島秀吉、佐藤敏文
- Organizer
  日本化学会北海道支部2022年夏季研究発表会
- Data Source
  KAKENHI-PROJECT-22K19907
[Presentation] 種々の側鎖構造を有するアミノ化ポリ(ε-カプロラクトン) 誘導体の合成と核酸デリバリー材料への応用2022
- Author(s)
  水上湧太、Mahmoud M. Abd Elwakil、佐藤悠介、磯野拓也、山本拓矢、田島健次、原島秀吉、佐藤敏文
- Organizer
  日本化学会北海道支部2022年夏季研究発表会
- Data Source
  KAKENHI-PROJECT-22K19907
[Presentation] ポリ(ε-カプロラクトン) 誘導体を構成成分とする mRNA 搭載脂質ナノ粒子の in vivo デリバリー2022
- Author(s)
  水上湧太、Mahmoud M. Abd Elwakil、佐藤悠介、磯野拓也、山本拓矢、田島健次、原島秀吉、佐藤敏文
- Organizer
  第51回医用高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-22K19907
[Presentation] アミノ化ポリ(ε-カプロラクトン)誘導体をベースとした脂質ナノ粒子による肺・脾臓選択的 mRNA デリバリー2022
- Author(s)
  水上湧太、Mahmoud M. Abd Elwakil、佐藤悠介、磯野拓也、山本拓矢、田島健次、原島秀吉、佐藤敏文
- Organizer
  第71回高分子討論会
- Data Source
  KAKENHI-PROJECT-22K19907
[Presentation] マイクロ流体デバイスによる脂質ナノ粒子の粒径制御とin vivo RNA送達2022
- Author(s)
  佐藤悠介, 奥田健斗, 岩川和樹, 佐々木宏輔, 原島秀吉
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H03640
[Presentation] マイクロ流体デバイスによる脂質ナノ粒子の粒径制御とin vivo RNA送達2022
- Author(s)
  佐藤悠介、奥田健斗、岩川和樹、佐々木宏輔、原島秀吉
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] 脂質ナノ粒子の粒子径制御技術の確立と有用性の検討2021
- Author(s)
  奥田健斗, 佐藤悠介, 岩川和樹, 原島秀吉
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-19H03640
[Presentation] 機能性脂質を基盤とした脂質ナノ粒子製剤の開発とゲノム編集への応用2021
- Author(s)
  佐藤悠介
- Organizer
  第7回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] mRNA ワクチンへの応用を目指した脂質ナノ粒子の粒子径制御技術の確立2021
- Author(s)
  奥田健斗, 佐藤悠介, 岩川和樹, 原島秀吉
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-19H03640
[Presentation] 脂質ナノ粒子の粒子径増大技術の確立とその有用性の検討2021
- Author(s)
  奥田健斗, 佐藤悠介, 岩川和樹, 原島秀吉
- Organizer
  日本薬学会北海道支部第148回例会
- Data Source
  KAKENHI-PROJECT-19H03640
[Presentation] 効率的かつ安全な高分子送達を可能とする脂質ナノ粒子製剤の開発2021
- Author(s)
  佐藤悠介
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] 低温下での脂質ナノ粒子の免疫細胞表面への結合が引き起こすトランスフェクション活性の消失2021
- Author(s)
  中村孝司、山田小春、佐藤悠介、原島秀吉
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Nucleic Acid Drugs and Nanomedicine: Multifunctional Envelope-type Nano Device for Nanomedicine2020
- Author(s)
  Hideyoshi Harashima, Yusuke Sato, Takashi Nakamura, Yuma Yamada
- Organizer
  The 79 Annual Meeting of the Japanese Cancer Association.
- Invited
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] ゲノム編集タンパク質搭載脂質ナノ粒子の開発とHBV抑制効果の検証2020
- Author(s)
  佐藤悠介
- Organizer
  第27回次世代医工学研究会
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] 脂質ナノ粒子の特性がリンパ節送達とリンパ節内分布へ与える影響2020
- Author(s)
  中村孝司、河合美典、佐藤悠介、真栄城正寿、渡慶次学、原島秀吉
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids2019
- Author(s)
  Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids2019
- Author(s)
  Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19889
[Presentation] Development of Ribonucleoprotein-loaded lipid nanoparticles for genome editing2019
- Author(s)
  Suzuki Y, Sato Y, Sato R, Maeki M, Tokeshi M, Harashima H
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] ゲノム編集タンパク質搭載脂質ナノ粒子の開発2019
- Author(s)
  佐藤悠介, 鈴木裕一, 佐藤里咲, 真栄城正寿, 渡慶次学, 原島秀吉
- Organizer
  日本核酸医薬学学会第5回年会
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] Cas9-gRNA RNP搭載脂質ナノ粒子による高効率ゲノム編集2019
- Author(s)
  佐藤悠介, 鈴木裕一, 佐藤里咲, 真栄城正寿, 渡慶次学, 原島秀吉
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids2019
- Author(s)
  Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids.2019
- Author(s)
  Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H.
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03640
[Presentation] siRNAデリバリーが可能な直径20 nmの極小脂質ナノ粒子の開発2018
- Author(s)
  岡部奈々, 佐藤悠介, 真栄城正寿, 渡慶次学, 原島秀吉
- Organizer
  日本薬学会北海道支部第145回例会
- Data Source
  KAKENHI-PROJECT-18K19889
[Presentation] 効率的なin vivo核酸送達を実現する高機能脂質ナノ粒子2018
- Author(s)
  佐藤悠介, 橋場一毅, 原島秀吉.
- Organizer
  第27回インテリジェント材料・システムシンポジウム
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] 優れたsiRNA送達効率と安全性を両立する脂質ナノ粒子の開発2018
- Author(s)
  佐藤悠介, 橋場一毅, 原島秀吉.
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] 脂質ナノ粒子の膜酸乖離定数の操作による細胞選択的なsiRNA送達2017
- Author(s)
  ショバキヌレ, 佐藤悠介, 原島秀吉.
- Organizer
  第3回日本核酸医薬学会
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] 肝臓標的型siRNA送達システムの安全性向上に関する検討2017
- Author(s)
  佐藤里咲, 佐藤悠介, 松井秀樹, 原島秀吉
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K20831
[Presentation] Targeted delivery of siRNAs by manipulating acid dissociation constant of lipid nanoparticles2017
- Author(s)
  Shobaki N, Sato Y, Harashima H.
- Organizer
  The 5th International Life Science Symposium for Young Scientists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] 機能性脂質を基盤としたin vivo核酸送達システムの開発2017
- Author(s)
  佐藤悠介.
- Organizer
  日本薬学会北海道支部主催第1回若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] 新規pH応答性脂質の開発による効率的なin vivo siRNAデリバリー2017
- Author(s)
  橋場一毅, 佐藤悠介, 原島秀吉.
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] メカニズムに基づいた安全性の高いsiRNA搭載脂質ナノ粒子の開発とB型肝炎治療への応用2017
- Author(s)
  佐藤悠介, 松井秀樹, 佐藤里咲, 原島秀吉
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K20831
[Presentation] Optimizing siRNA delivery using specific multifunctional envelope-type nanodevice for liver sinusoidal endothelial cells2016
- Author(s)
  Shobaki N, Sato Y, Harashima H
- Organizer
  AsiaNANO 2016: Asian Conference on Nanoscience and Nanotechnology
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-10-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20831
[Presentation] 肝臓を標的としたsiRNA搭載脂質ナノ粒子の物理化学的性質がsiRNA導入効率に及ぼす影響の評価2016
- Author(s)
  佐藤悠介, 野手雄介, ショバキヌレ, 原島秀吉
- Organizer
  第2回日本核酸医薬学会
- Place of Presentation
  東京理科大学（東京都葛飾区）
- Year and Date
  2016-11-15
- Data Source
  KAKENHI-PROJECT-15K20831
[Presentation] Development of siRNA delivery system for the treatment of hepatitis B viral infection2015
- Author(s)
  Yusuke Sato, Hiroto Hatakeyama, Naoki Yamamoto, Michinori Kohara, Hideyoshi Harashima
- Organizer
  The 18th Hokkaido University-Seoul National University Joint Sympojium
- Place of Presentation
  Seoul National University（韓国・ソウル）
- Year and Date
  2015-11-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20831
[Presentation] pH応答性脂質ナノ粒子による肝実質細胞選択的なsiRNA導入とB型肝炎治療2015
- Author(s)
  佐藤悠介, 畠山浩人, 兵藤守, 山本直樹, 小原道法, 原島秀吉
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本大学（熊本県熊本市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K20831
[Presentation] Elucidation of the physicochemical properties and potency for siRNA delivery of the siRNA-loaded small-sized nanoparticles2015
- Author(s)
  Yusuke Note, Yusuke Sato, Masatoshi Maeki, Manabu Tokeshi, Hideyoshi Harashima
- Organizer
  The 18th Hokkaido University-Seoul National University Joint Sympojium
- Place of Presentation
  Seoul National University（韓国・ソウル）
- Year and Date
  2015-11-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20831

1. HARASHIMA HIDEYOSHI (00183567)

# of Collaborated Projects: 3 results

# of Collaborated Products: 35 results
2. 中村孝司 (20604458)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. Tanaka Yasuhito (90336694)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 山田勇磨 (60451431)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. MATSUDA Akira (90157313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SATO Kosuke (70415686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. Isono Takuya (70740075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
8. 大石久史 (30375513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 佐藤敏文 (80291235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
10. 西山伸宏 (10372385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 内田智士 (20710726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
12. 石垣和慶 (00790338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山野友義 (40724183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 馬場理也 (10347304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 田中義正 (90280700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAGAOKA KATSUYA

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. MATSUURA Kentarou

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. MIURA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 畠山浩人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 小原道法

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 秋田英万

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. ディリサラアンジャネユル

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 棟方翼

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 松井誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sato Yusuke 佐藤 悠介

SATO Yusuke 佐藤 悠介

Research Projects

Research Products

Co-Researchers

ナノDDSによる生体内機能強化NK細胞の創出と新規がん免疫療法基盤の構築

Principal Investigator

Project Period (FY)

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Nucleic acid-loaded lipid nanoparticles enabling in vivo engineering of neutrophilsPrincipal Investigator

Principal Investigator

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Review Section

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Activated mRNA delivery system based on core-shell structured LNP with smart polymers

Principal Investigator

Project Period (FY)

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Review Section

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全身投与型Cas9 RNP搭載脂質ナノ粒子製剤による脳でのゲノム編集Principal Investigator

Principal Investigator

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Review Section

Research Institution

Drug discovery research targeting the lysosomal nutrient sensing mechanism for the prevention of NASH-related liver cancer

Principal Investigator

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Review Section

Research Institution

Strategic creation of polymer-lipid hybrid nanoparticles for tissue-selective nucleic acid delivery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Innovative gene/nucleic acid delivery system based on optimized intracellular trafficking steps

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Identification of novel therapeutic target for liver fibrosis and elucidation of the mechanism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

novel cancer treatment by highly permeable small-sized siRNA-loaded lipid nanoparticlesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

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Development of lipid nanoparicles for treatment of hepatic diseases by in vivo genome editingPrincipal Investigator

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Development of niucleic delivery system for targeting primary and metametastatic tumorPrincipal Investigator

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肝細胞標的siRNA送達システムの創製：体内動態と細胞内動態の真の両立Principal Investigator

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Targeting of the nuclease-resistant functional oligonucleotides

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Sato Yusuke 佐藤悠介

SATO Yusuke 佐藤悠介

[Book] 医薬ジャーナル　2014年7月号(Vol.50 No.7)2014