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Sato Yusuke  佐藤 悠介

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SATO Yusuke  佐藤 悠介

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Researcher Number 10735624
Other IDs
External Links
Affiliation (Current) 2020: 北海道大学, 薬学研究院, 助教
Affiliation (based on the past Project Information) *help 2016 – 2020: 北海道大学, 薬学研究院, 助教
2014 – 2015: 北海道大学, 薬学研究科(研究院), 特任助教
2014: 北海道大学, 大学院薬学研究院, 特任助教
Review Section/Research Field
Principal Investigator
Physical pharmacy / Medical pharmacy / Biomedical engineering/Biomaterial science and engineering / Medium-sized Section 90:Biomedical engineering and related fields
Except Principal Investigator
Drug development chemistry / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 53010:Gastroenterology-related
Keywords
Principal Investigator
siRNA / 脂質ナノ粒子 / 核酸送達 / 粒子径 / マイクロ流体デバイス / 脂質ナノキャリア / pH応答性 / 体内動態 / 細胞内動態 / PEG … More / デリバリー / がん浸透性 / 動態制御 / 薬物送達 / 粒径 / ゲノム編集 / in vivoゲノム編集 / RNP送達 / pH感受性カチオン性脂質 / 肝疾患治療 / ph感受性カチオン性脂質 / 安全治療域 / タンパク質送達 / RNP / In vivoゲノム編集 / RNA送達 / 足場構造 / 遺伝子ノックダウン / 粒径制御 / がん治療 / 組織浸透 … More
Except Principal Investigator
核酸医薬 / 組織標的化 / PSMA / オリゴヌクレオチド / ヌクレアーゼ抵抗性 / SPAAC / DNMT1 / stat3 / 核酸創薬 / 2'-OMe-4'-チオリポヌクレオシド / アンチマイクロRNA / shRNA / ホスホロチオエート結合 / ホスホジエステル結合 / 核酸ナノ医療 / 細胞内動態制御 / ナノDDS / がん免疫療法 / ミトコンドリア遺伝子治療 / siRNA / 細胞内局在 / 脂質ナノ粒子 / ミトコンドリア / 核酸送達 / 遺伝子治療 / ナノDDS / HCV / 肝臓線維化 / TLL1 / miRNA / MEND / 肝線維化 Less
  • Research Projects

    (7 results)
  • Research Products

    (52 results)
  • Co-Researchers

    (24 People)
  •  Innovative gene/nucleic acid delivery system based on optimized intracellular trafficking stepsOngoing

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Hokkaido University
  •  Identification of novel therapeutic target for liver fibrosis and elucidation of the mechanismOngoing

    • Principal Investigator
      田中 靖人
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Nagoya City University
  •  novel cancer treatment by highly permeable small-sized siRNA-loaded lipid nanoparticlesPrincipal Investigator

    • Principal Investigator
      Sato Yusuke
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Hokkaido University
  •  Development of lipid nanoparicles for treatment of hepatic diseases by in vivo genome editingPrincipal Investigator

    • Principal Investigator
      Sato Yusuke
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      Hokkaido University
  •  Development of niucleic delivery system for targeting primary and metametastatic tumorPrincipal Investigator

    • Principal Investigator
      SATO Yusuke
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Physical pharmacy
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      Hokkaido University
  •  肝細胞標的siRNA送達システムの創製:体内動態と細胞内動態の真の両立Principal Investigator

    • Principal Investigator
      佐藤 悠介
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Medical pharmacy
    • Research Institution
      Hokkaido University
  •  Targeting of the nuclease-resistant functional oligonucleotides

    • Principal Investigator
      MATSUDA Akira
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Drug development chemistry
    • Research Institution
      Hokkaido University

All 2020 2019 2018 2017 2016 2015 2014 2011

All Journal Article Presentation Book Patent

  • [Book] 医薬ジャーナル 2014年7月号(Vol.50 No.7)2014

    • Author(s)
      佐藤悠介・中村孝司・山田勇磨・原島秀吉
    • Total Pages
      200
    • Publisher
      医薬ジャーナル社
    • Data Source
      KAKENHI-PROJECT-26893001
  • [Book] Advances in Genetics Volume 88 Nonviral Vectors for Gene Therapy Lipid- and Polymer-based Gene Transfer2014

    • Author(s)
      Sato Y, Nakamura T, Yamada Y, Akita H, Harashima H.
    • Total Pages
      409
    • Publisher
      ELSEVIER
    • Data Source
      KAKENHI-PROJECT-26893001
  • [Journal Article] The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution2020

    • Author(s)
      Nakamura Takashi, Kawai Minori, Sato Yusuke, Maeki Masatoshi, Tokeshi Manabu, Harashima Hideyoshi
    • Journal Title

      Molecular Pharmaceutics

      Volume: 17 Pages: 944-953

    • DOI

      10.1021/acs.molpharmaceut.9b01182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03974, KAKENHI-PROJECT-18K19889
  • [Journal Article] Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles2020

    • Author(s)
      Sato Y, Okabe N, Note Y, Hashiba K, Maeki M, Tokeshi M, Harashima H
    • Journal Title

      Acta Biomaterialia

      Volume: 102 Pages: 341-350

    • DOI

      10.1016/j.actbio.2019.11.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
  • [Journal Article] A study of the endocytosis mechanism and transendothelial activity of lung-targeted GALA-modified liposomes.2019

    • Author(s)
      Santiwarangkool S, Akita H, Khalil IA, Abd Elwakil MM, Sato Y, Kusumoto K, Harashima H.
    • Journal Title

      J Control Release.

      Volume: 307 Pages: 55-63

    • DOI

      10.1016/j.jconrel.2019.06.009

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Journal Article] Innovative nanotechnologies for enhancing nucleic acids/gene therapy: Controlling intracellular trafficking to targeted biodistribution.2019

    • Author(s)
      Nakamura Takashi, Yamada Yuma, Sato Yusuke, Khalil A Ikramy, Harashima Hideyoshi
    • Journal Title

      Biomaterials.

      Volume: 218 Pages: 119329-119329

    • DOI

      10.1016/j.biomaterials.2019.119329

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19888, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-17H03974, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
  • [Journal Article] Recent advances in the targeting of systemically administered non-viral gene delivery systems2019

    • Author(s)
      Khalil IA, Sato Y, Harashima H.
    • Journal Title

      Expert Opinion on Drug Delivery

      Volume: 16 Pages: 1037-1050

    • DOI

      10.1080/17425247.2019.1656196

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
  • [Journal Article] Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo2019

    • Author(s)
      Yusuke Sato, Kazuki Hashiba, Kosuke Sasaki, Masatoshi Maeki, Manabu Tokeshi, HIdeyoshi Harashima
    • Journal Title

      Journal of Controlled Release

      Volume: 295 Pages: 140-152

    • DOI

      10.1016/j.jconrel.2019.01.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Journal Article] Development of the iLiNP Device: Fine Tuning the Lipid Nanoparticle Size within 10 nm for Drug Delivery2018

    • Author(s)
      Niko Kimura, Masatoshi Maeki, Yusuke Sato, Yusuke Note, Akihiko Ishida, Hirofumi Tani, Hideyoshi Harashima, Manabu Tokeshi
    • Journal Title

      ACS Omega

      Volume: 3 Pages: 5044-5041

    • DOI

      10.1021/acsomega.8b00341

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Journal Article] Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers2017

    • Author(s)
      Maeki M, Fujishima Y, Sato Y, Yasui T, Kaji N, Ishida A, Tani H, Baba Y, Harashima H, Tokeshi M
    • Journal Title

      PLoS One

      Volume: 12

    • DOI

      10.1371/journal.pone.0187962

    • NAID

      120006377541

    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Journal Article] pH-labile PEGylation of siRNA-loaded lipid nanoparticle improves active targeting and gene silencing activity in hepatocytes2017

    • Author(s)
      Hashiba K, Sato Y, Harashima H
    • Journal Title

      J. Control. Release

      Volume: 262 Pages: 239-246

    • DOI

      10.1016/j.jconrel.2017.07.046

    • NAID

      120006523729

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Journal Article] Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus2017

    • Author(s)
      Sato Y, Matsui H, Yamamoto N, Sato R, Munakata T, Kohara M, Harashima H
    • Journal Title

      Journal of Controlled Release

      Volume: 266 Pages: 216-225

    • DOI

      10.1016/j.jconrel.2017.09.044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08871, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-15K19120
  • [Journal Article] Innovative Technologies in Nanomedicines: From Passive Targeting to Active Targeting/From Controlled Pharmacokinetics to Controlled Intracellular Pharmacokinetics.2017

    • Author(s)
      Sato Y, Sakurai Y, Kajimoto K, Nakamura T, Yamada Y, Akita H, Harashima H.
    • Journal Title

      Macromolecular Biosciences

      Volume: 17 Pages: 1-16

    • DOI

      10.1002/mabi.201600179

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26282132, KAKENHI-PROJECT-26713002, KAKENHI-PROJECT-26670741, KAKENHI-PROJECT-15K20831, KAKENHI-PROJECT-16K11180
  • [Journal Article] マイクロ流体デバイスによる脂質ナノ粒子作製とDDSへの応用2016

    • Author(s)
      真栄城正寿, 佐藤悠介, 原島秀吉, 渡慶次学
    • Journal Title

      機能材料

      Volume: 36 Pages: 15-21

    • Data Source
      KAKENHI-PROJECT-15K20831
  • [Journal Article] Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery2016

    • Author(s)
      Yusuke Sato, Yusuke Note, Masatoshi Maeki, Noritada Kaji, Yoshinobu Baba, Manabu Tokeshi, Hideyoshi Harashima
    • Journal Title

      Journal of Controlled Release

      Volume: 229 Pages: 48-57

    • DOI

      10.1016/j.jconrel.2016.03.019

    • NAID

      120006219995

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K20831
  • [Journal Article] Development of a multifunctional envelope-type nano device and its application to nanomedicine2016

    • Author(s)
      Sato Y, Nakamura T, Yamada Y, Harashima H.
    • Journal Title

      J Control Release.

      Volume: 244 Pages: 194-204

    • DOI

      10.1016/j.jconrel.2016.06.042

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26713002, KAKENHI-PROJECT-26670741, KAKENHI-PROJECT-15K20831, KAKENHI-PROJECT-16K11180
  • [Journal Article] pH感受性脂質を基盤とした脂質ナノ粒子の開発と核酸ナノメディシンへの応用2016

    • Author(s)
      佐藤悠介, 原島秀吉
    • Journal Title

      化学工業

      Volume: 67 Pages: 21-27

    • Data Source
      KAKENHI-PROJECT-15K20831
  • [Journal Article] Relationship Between the Physicochemical Properties of Lipid Nanoparticles and the Quality of siRNA Delivery to Liver Cells.2016

    • Author(s)
      Yusuke Sato, Hiroto Hatakeyama, Mamoru Hyodo, Hideyoshi Harashima
    • Journal Title

      Mol Ther.

      Volume: 24 Pages: 788-795

    • DOI

      10.1038/mt.2015.222

    • NAID

      120005906929

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K20831, KAKENHI-PROJECT-26830101
  • [Journal Article] The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus2015

    • Author(s)
      Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, Watanabe T, Iijima S, Sakurai Y, Watashi K, Tsutsumi S, Sato Y, Akita H, Wakita T, Rice CM, Harashima H, Kohara M, Tanaka Y, Takaoka A
    • Journal Title

      Immunity

      Volume: 42 Pages: 123-132

    • DOI

      10.1016/j.immuni.2014.12.016

    • NAID

      120005822521

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390117, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-25253030, KAKENHI-PROJECT-25870015, KAKENHI-PROJECT-25893001, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-26893001
  • [Journal Article] In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.2014

    • Author(s)
      Watanabe T, Hatakeyama H, Matsuda-Yasui C, Sato Y, Sudoh M, Takagi A, Hirata Y, Ohtsuki T, Arai M, Inoue K, Harashima H, Kohara M
    • Journal Title

      Sci Rep

      Volume: in press Pages: 4750-4750

    • DOI

      10.1038/srep04750

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-24390117, KAKENHI-PROJECT-24590988, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-25860305, KAKENHI-PROJECT-26893001
  • [Journal Article] Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain.2014

    • Author(s)
      Tamaru M, Akita H, Nakatani T, Kajimoto K, Sato Y, Hatakeyama H, Harashima H.
    • Journal Title

      Int J Nanomedicine

      Volume: 9 Pages: 4267-4276

    • DOI

      10.2147/ijn.s65402

    • NAID

      120005476202

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26893001
  • [Journal Article] Multifunctional envelope-type nano device for controlled intracellular trafficking and selective targeting in vivo.2014

    • Author(s)
      Kazuaki Kajimoto, Yusuke Sato, Takashi Nakamura, Yuma Yamada, Hidesyoshi Harashima.
    • Journal Title

      J Control Release

      Volume: 190 Pages: 593-606

    • DOI

      10.1016/j.jconrel.2014.03.058

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25560219, KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26893001
  • [Journal Article] Selective transcription of an unnatural Naphthyridine:Imidazopyridopyrimidine base pair containing four hydrogen bonds with T7 RNA polymerase.2014

    • Author(s)
      Nomura, Y.; Kashiwagi, S.; Sato, K.; Matsuda, A.
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 53 Pages: 12844-12848

    • DOI

      10.1002/anie.201406402

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-25410165
  • [Journal Article] The systematic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice.2014

    • Author(s)
      Hiroto Hatakeyama, Manami Murata, Yusuke Sato, Mayumi Takahashi, Noriyuki Minakawa, Akira Matsuda, Hideyoshi Harashima
    • Journal Title

      Journal of Controled Release

      Volume: 173 Pages: 43-50

    • DOI

      10.1016/j.jconrel.2013.10.023

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-23249008, KAKENHI-PUBLICLY-24107502, KAKENHI-PUBLICLY-24107518
  • [Journal Article] An apolipoprotein E modified liposomal nanoparticle: ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells.2014

    • Author(s)
      Mina Tamaru, Hidetaka Akita, Kazuaki Kajimoto, Yusuke Sato, Hiroto Hatakeyama, Hideyoshi Harashima
    • Journal Title

      Int J Pharm

      Volume: 465 Pages: 77-82

    • DOI

      10.1016/j.ijpharm.2014.02.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-11J05746, KAKENHI-PROJECT-26893001
  • [Journal Article] Highly Fluorescent 5-(5,6-Dimethoxy- benzothiazol-2-yl)-2'-Deoxyuridine 5'-Triphosphate as an Efficient Substrate for DNA Polymerases2011

    • Author(s)
      Sato, K.
    • Journal Title

      ChemBioChem

      Volume: 12 Pages: 2341-2346

    • DOI

      10.1002/cbic.201100452

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-23750178
  • [Patent] 脂質ナノ粒子2019

    • Inventor(s)
      佐藤悠介, 原島秀吉, 渡慶次学, 真栄城正寿
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-101203
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Patent] siRNA細胞内送達のための脂質膜構造体2018

    • Inventor(s)
      原島秀吉, 佐藤悠介
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Overseas
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Patent] siRNA細胞内送達のための脂質膜構造体2017

    • Inventor(s)
      原島秀吉, 佐藤悠介
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-117708
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Patent] 肝線維化修復剤2015

    • Inventor(s)
      中島美紀, 小田祐輝, 原島秀吉, 佐藤悠介
    • Industrial Property Rights Holder
      金沢大学, 北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-020308
    • Filing Date
      2015-02-04
    • Data Source
      KAKENHI-PROJECT-26893001
  • [Patent] 脂質膜構造体2014

    • Inventor(s)
      原島秀吉, 佐藤悠介, など
    • Industrial Property Rights Holder
      北海道大学, 公益財団法人東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-217011
    • Filing Date
      2014-10-24
    • Data Source
      KAKENHI-PROJECT-26893001
  • [Presentation] Cas9-gRNA RNP搭載脂質ナノ粒子による高効率ゲノム編集2019

    • Author(s)
      佐藤悠介, 鈴木裕一, 佐藤里咲, 真栄城正寿, 渡慶次学, 原島秀吉
    • Organizer
      日本ゲノム編集学会第4回大会
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids2019

    • Author(s)
      Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H
    • Organizer
      Liposome Research Days 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01170
  • [Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids2019

    • Author(s)
      Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H
    • Organizer
      Liposome Research Days 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids2019

    • Author(s)
      Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H
    • Organizer
      Liposome Research Days 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19889
  • [Presentation] Development of Ribonucleoprotein-loaded lipid nanoparticles for genome editing2019

    • Author(s)
      Suzuki Y, Sato Y, Sato R, Maeki M, Tokeshi M, Harashima H
    • Organizer
      Liposome Research Days 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Presentation] ゲノム編集タンパク質搭載脂質ナノ粒子の開発2019

    • Author(s)
      佐藤悠介, 鈴木裕一, 佐藤里咲, 真栄城正寿, 渡慶次学, 原島秀吉
    • Organizer
      日本核酸医薬学学会第5回年会
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids.2019

    • Author(s)
      Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H.
    • Organizer
      Liposome Research Days 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03640
  • [Presentation] 優れたsiRNA送達効率と安全性を両立する脂質ナノ粒子の開発2018

    • Author(s)
      佐藤悠介, 橋場一毅, 原島秀吉.
    • Organizer
      日本薬学会第137年会
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Presentation] 効率的なin vivo核酸送達を実現する高機能脂質ナノ粒子2018

    • Author(s)
      佐藤悠介, 橋場一毅, 原島秀吉.
    • Organizer
      第27回インテリジェント材料・システムシンポジウム
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Presentation] siRNAデリバリーが可能な直径20 nmの極小脂質ナノ粒子の開発2018

    • Author(s)
      岡部奈々, 佐藤悠介, 真栄城正寿, 渡慶次学, 原島秀吉
    • Organizer
      日本薬学会北海道支部第145回例会
    • Data Source
      KAKENHI-PROJECT-18K19889
  • [Presentation] Targeted delivery of siRNAs by manipulating acid dissociation constant of lipid nanoparticles2017

    • Author(s)
      Shobaki N, Sato Y, Harashima H.
    • Organizer
      The 5th International Life Science Symposium for Young Scientists
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Presentation] 脂質ナノ粒子の膜酸乖離定数の操作による細胞選択的なsiRNA送達2017

    • Author(s)
      ショバキ ヌレ, 佐藤悠介, 原島秀吉.
    • Organizer
      第3回日本核酸医薬学会
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Presentation] メカニズムに基づいた安全性の高いsiRNA搭載脂質ナノ粒子の開発とB型肝炎治療への応用2017

    • Author(s)
      佐藤悠介, 松井秀樹, 佐藤里咲, 原島秀吉
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K20831
  • [Presentation] 機能性脂質を基盤としたin vivo核酸送達システムの開発2017

    • Author(s)
      佐藤悠介.
    • Organizer
      日本薬学会北海道支部主催 第1回若手シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Presentation] 肝臓標的型siRNA送達システムの安全性向上に関する検討2017

    • Author(s)
      佐藤里咲, 佐藤悠介, 松井秀樹, 原島秀吉
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K20831
  • [Presentation] 新規pH応答性脂質の開発による効率的なin vivo siRNAデリバリー2017

    • Author(s)
      橋場一毅, 佐藤悠介, 原島秀吉.
    • Organizer
      第39回生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-17H05052
  • [Presentation] 肝臓を標的としたsiRNA搭載脂質ナノ粒子の物理化学的性質がsiRNA導入効率に及ぼす影響の評価2016

    • Author(s)
      佐藤悠介, 野手雄介, ショバキ ヌレ, 原島秀吉
    • Organizer
      第2回日本核酸医薬学会
    • Place of Presentation
      東京理科大学(東京都葛飾区)
    • Year and Date
      2016-11-15
    • Data Source
      KAKENHI-PROJECT-15K20831
  • [Presentation] Optimizing siRNA delivery using specific multifunctional envelope-type nanodevice for liver sinusoidal endothelial cells2016

    • Author(s)
      Shobaki N, Sato Y, Harashima H
    • Organizer
      AsiaNANO 2016: Asian Conference on Nanoscience and Nanotechnology
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20831
  • [Presentation] pH応答性脂質ナノ粒子による肝実質細胞選択的なsiRNA導入とB型肝炎治療2015

    • Author(s)
      佐藤悠介, 畠山浩人, 兵藤守, 山本直樹, 小原道法, 原島秀吉
    • Organizer
      第37回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-15K20831
  • [Presentation] Elucidation of the physicochemical properties and potency for siRNA delivery of the siRNA-loaded small-sized nanoparticles2015

    • Author(s)
      Yusuke Note, Yusuke Sato, Masatoshi Maeki, Manabu Tokeshi, Hideyoshi Harashima
    • Organizer
      The 18th Hokkaido University-Seoul National University Joint Sympojium
    • Place of Presentation
      Seoul National University(韓国・ソウル)
    • Year and Date
      2015-11-26
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20831
  • [Presentation] Development of siRNA delivery system for the treatment of hepatitis B viral infection2015

    • Author(s)
      Yusuke Sato, Hiroto Hatakeyama, Naoki Yamamoto, Michinori Kohara, Hideyoshi Harashima
    • Organizer
      The 18th Hokkaido University-Seoul National University Joint Sympojium
    • Place of Presentation
      Seoul National University(韓国・ソウル)
    • Year and Date
      2015-11-26
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20831
  • 1.  MATSUDA Akira (90157313)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  SATO Kosuke (70415686)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  原島 秀吉 (00183567)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 4.  中村 孝司 (20604458)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 5.  山田 勇磨 (60451431)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 6.  田中 靖人 (90336694)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  大石 久史 (30375513)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  WATANABE Tsunamasa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  SATO Seiichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  KAJIMOTO Kazuyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  HYOUDOU Mamoru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  畠山 浩人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 13.  安井 文彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  平田 雄一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  小原 道法
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 16.  大槻 貴博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  芫岡 晃教
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  櫻井 遊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 19.  渡士 幸一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  南川 典昭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  棟方 翼
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  山本 直樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  秋田 英万
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  喜多 知子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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