Higashikawa Kei 東川桂

Researcher Number	10756878
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2023: 北海道大学, アイソトープ総合センター, 助教
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related Except Principal Investigator Radiation science / Medium-sized Section 52:General internal medicine and related fields / Basic Section 52040:Radiological sciences-related / General internal medicine and related fields
Keywords	Principal Investigator NASH / 核医学 / チミジンホスホリラーゼ / SS / [123I]IIMU / TP / 核医学診断薬 / Ｐｒｏｐｅｒｄｉｎ / 補体 / 慢性炎症 … More / 分子イメージング / メチオニン・コリン欠乏食 / 非アルコール性脂肪肝炎 / [123/125I]IIMU … More Except Principal Investigator 放射線 / 核医学 / 核医学治療 / 癌 / 組織因子 / α線治療 / がん免疫 / α線 / プロテオーム / 質量分析イメージング / Id-1 / イメージング / 腫瘍 / がん治療 / 細胞老化 / アスタチン / 治療用放射性薬剤 / チミジンホスホリラーゼ / 5-フルオロウラシル / ＰＥＴ／ＳＰＥＣＴ / IIMU / がんの核医学的分子イメージング / ５－FUプロドラッグ / 5-フルオロウラシル（5-FU） / 担癌モデル動物 / 抗がん剤Paclitaxel / プロドラッグ / 5－フルオロウラシル（5-FU) / SPECTイメージング / 核医学診断薬 / ヨウ素標識IIMU / チミジンホスホリラーゼ（TP） / 薬学 / がんのイメージング / がんイメージング / 細胞周期制御因子 / サイクリン依存性キナーゼ / CDK2 / がんのイメジング / ディスポ・チップ型 / PET薬剤合成装置 / ディスポチップ / 自己遮蔽型 / オン・デマンド / 薬剤合成装置 / PET / グリオキサラーゼI / 放射性医薬品 / 悪性度診断 / 治療効果予測 / 質的診断 / 放射性分子プローブ / グリオキサラーゼⅠ / がん / インテグリンαvβ3 / インテグリンαvβ３ / マクロファージ / 低酸素イメージング / 不安定プラーク / 核医学診断 / 動脈硬化 / RI内用療法 Less

PD-ECGF targeted tumor treatment with new At-211 radiolabeled uracil derivatives
- Principal Investigator
  
  NISHIJIMA Ken-ichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Fukushima Medical University
Development of a MS imaging-based diagnosis for novel cancer senotherapy
- Principal Investigator
  
  Yasui Hironobu
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Hokkaido University
Why does alpha-ray therapy work? Approaching the question from the viewpoint of cancer immunity
- Principal Investigator
  
  Ogawa Mikako
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Hokkaido University
生検に代わる診断法：NASH鑑別診断を可能とする新規核医学イメージング法の開発Principal Investigator
- Principal Investigator
  
  東川桂
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hokkaido University
Development of an imaging method of complement complex for the diagnosis of chronic inflammatory diseasePrincipal Investigator
- Principal Investigator
  
  Higashikawa Kei
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
A new disposable chip type PET drug synthesizer for on-demand PET examination
- Principal Investigator
  
  KUGE YUJI
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  Hokkaido University
Development of a radioactive probe targeting the cell cycle regulatory factor CDK2
- Principal Investigator
  
  Kitaura Hirotake
- Project Period (FY)
  2017 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
Development of a radiolabeled probe to detect a novel target, glyoxalase I, for diagnosing characteristics of cancers
- Principal Investigator
  
  AKIZAWA Hiromichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Showa Pharmaceutical University
Prediction of response to anticancer therapy by thymidine phosphorylase imaging: pre-clinical proof of concept
- Principal Investigator
  
  Zhao Songji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Fukushima Medical University
A Challenge of radio-isotope therapy for atherosclerosis: Development of a radiopharmaceutical to suppress macrophage infiltration
- Principal Investigator
  
  KUGE YUJI
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Development of a diagnostic method for nonalcoholic steatohepatitis by visualization of thymidine phosphorylasePrincipal Investigator
- Principal Investigator
  
  Higashikawa Kei
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Nuclear medicine imaging toward therapeutic strategy of atherosclerosis: Experimental research to establish EBM
- Principal Investigator
  
  KUGE Yuji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University

All 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Preclinical investigation of potential use of thymidine phosphorylase-targeting tracer for diagnosis of nonalcoholic steatohepatitis2020
- Author(s)
  Higashikawa Kei、Horiguchi Sawako、Tarisawa Makoto、Shibata Yuki、Ohkura Kazue、Yasui Hironobu、Takeda Hiroshi、Kuge Yuji
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 82-83 Pages: 25-32
- DOI
  10.1016/j.nucmedbio.2019.12.006
- NAID
  120006980029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17255, KAKENHI-PROJECT-20H00443, KAKENHI-PROJECT-18H03548, KAKENHI-PROJECT-18K19254
[Journal Article] Biodistribution and radiation dosimetry of the novel hypoxia PET probe [18F]DiFA and comparison with [18F]FMISO2019
- Author(s)
  Watanabe Shiro、Shiga Tohru、Hirata Kenji、Magota Keiichi、Okamoto Shozo、Toyonaga Takuya、Higashikawa Kei、Yasui Hironobu、Kobayashi Jun、Nishijima Ken-ichi、Iseki Ken、Matsumoto Hiroki、Kuge Yuji、Tamaki Nagara
- Journal Title
  
  EJNMMI Research
  
  Volume: 9 Issue: 1 Pages: 60-60
- DOI
  10.1186/s13550-019-0525-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08180, KAKENHI-PROJECT-17K10428
[Journal Article] Elimination of tumor hypoxia by eribulin demonstrated by 18F-FMISO hypoxia imaging in human tumor xenograft models2019
- Author(s)
  Zhao S, Yu W, Ukon N, Tan C, Nishijima K, Shimizu Y, Higashikawa K, Shiga T, Yamashita H, Tamaki N, Kuge Y.
- Journal Title
  
  EJNMMI Res
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335
[Journal Article] Elimination of tumor hypoxia by eribulin demonstrated by 18F-FMISO hypoxia imaging in human tumor xenograft models2019
- Author(s)
  Zhao Songji、Yu Wenwen、Ukon Naoyuki、Tan Chengbo、Nishijima Ken-ichi、Shimizu Yoichi、Higashikawa Kei、Shiga Tohru、Yamashita Hiroko、Tamaki Nagara、Kuge Yuji
- Journal Title
  
  EJNMMI Research
  
  Volume: 9 Issue: 1 Pages: 51-51
- DOI
  10.1186/s13550-019-0521-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08180, KAKENHI-PROJECT-18H02757
[Journal Article] [18F]DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia2018
- Author(s)
  Tan C, Zhao S, Higashikawa K, Wang Z, Kawabori M, Abumiya T, Nakayama N, Kazumata K, Ukon N, Yasui H, Tamaki N, Kuge Y, Shichinohe H, Houkin K
- Journal Title
  
  EJNMMI Res
  
  Volume: ８ Issue: 1 Pages: 35-35
- DOI
  10.1186/s13550-018-0392-6
- NAID
  120006482581
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335
[Presentation] チミジンホスホリラーゼイメージングプローブを用いた非アルコール性脂肪肝炎の鑑別法の開発研究2019
- Author(s)
  東川桂, 上原里穂, 堀口紗和子, 柴田悠貴, 足澤誠, 北浦廣剛, 安井博宣, 武田宏司, 久下裕司
- Organizer
  第14 回日本分子イメージング学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K17255
[Presentation] チミジンホスホリラーゼ標的プローブを非アルコール性脂肪肝炎診断に応用するためのin vivo機能解析2019
- Author(s)
  上原里穂, 東川桂, 堀口紗和子, 足澤誠, 柴田悠貴, 大久保直登, 北浦廣剛, 安井博宣, 久下裕司, 武田宏司
- Organizer
  第3回日本核医学会分科会放射薬品科学研究会/第19回放射性医薬品・画像診断薬研究会
- Data Source
  KAKENHI-PROJECT-19K17255
[Presentation] 含水18Ｆ溶液と濃縮18Ｆ化法による18-FMISOの18Ｆ化反応の検討2019
- Author(s)
  阿保憲史，桐生真登，東川桂，志賀哲，久下裕司
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K19640
[Presentation] チミジンホスホリラーゼ標的核医学イメージングプローブを用いた非侵襲的NASH診断法の開発研究2019
- Author(s)
  東川桂, 上原里穂, 堀口紗和子, 柴田悠貴, 足澤誠, 北浦廣剛, 安井博宣, 武田宏司, 久下裕司
- Organizer
  第72回日本酸化ストレス学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17255
[Presentation] Investigation of the potentials of a thymidine phosphorylase imaging probe for the differential diagnosis of nonalcoholic steatohepatitis2019
- Author(s)
  Kei Higashikawa, Riho Uehara, Sawako Horiguchi, Yuki Shibata, Makoto Tarisawa, Hirotake Kitaura, Hironobu Yasui, Hiroshi Takeda, Yuji Kuge
- Organizer
  The 23rd International Symposium on Radiopharmaceutical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17255
[Presentation] Investigation of the influence of intratumoral glutathione status on the distribution of a hypoxic probe [18F]FMISO.2018
- Author(s)
  Yasui H, Higashikawa K, Shimizu Y, Shibata Y, Zhao S, Matsumoto H, Shiga T, Tamaki N, Kuge Y.
- Organizer
  WFNMB 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335
[Presentation] チミジンホスホリラーゼイメージングプローブによる非アルコール性脂肪肝炎の診断法の開発研究。2018
- Author(s)
  東川桂、堀口紗和子、足澤誠、小松由紀子、大倉一枝、安井博宣、武田宏司、久下裕司。
- Organizer
  第13回日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-16K10335
[Presentation] Feasibility and potentials of thymidine phosphorylase (TP) as an imaging biomarker and its nuclear medicine imaging for the diagnosis of non-alcoholic　steatohepatitis.2018
- Author(s)
  Higashikawa K, Horiguchi S, Ebita Y, Tarisawa M, Komatsu Y, Ohkura K, Yasui H, Takeda H, Kuge Y.
- Organizer
  Society of Nuclear Medicine and Molecular Imaging 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335
[Presentation] Potentials of a thymidine phosphorylase imaging agent in the diagnosis of nonalcoholic steatohepatitis.2018
- Author(s)
  Higashikawa K, Horiguchi S, Uehara R, Tarisawa M, Shibata Y, Kitaura H, Yasui H, Takeda H, Kuge Y.
- Organizer
  The Tenth China-Japan-Korea Symposium on Radiopharmaceutical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335
[Presentation] マクロファージの極性化が18F-FMISOと125I-BMIPPの集積に及ぼす影響2017
- Author(s)
  1.本村新，志水陽一，高倉栄男，安井博宣，東川桂，玉木長良，久下裕司，小川美香子
- Organizer
  第1回放射性薬品科学研究会(京都市)
- Data Source
  KAKENHI-PROJECT-26293268
[Presentation] Effect of eribulin on remodeling of tumor vasculature confirmed by FMISO PET imaging-Small-animal PET study in human breast cancer cell xenograft-2017
- Author(s)
  Zhao S, Yu W, Ukon N, Nishijima K, Shimizu Y, Higashikawa K, Yamashita H, Tamaki N, Kuge Y.
- Organizer
  The 64th Society of Nuclear Medicine Annual Meeting in Denver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335

1. KUGE YUJI (70321958)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. NISHIJIMA Ken-ichi (60364254)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. 志水陽一 (90634212)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. 大倉一枝 (60094827)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. AKIZAWA Hiromichi (90311795)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Zhao Songji (80374239)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. 志賀哲 (80374495)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. Kitaura Hirotake (10281817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Yasui Hironobu (10570228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Ogawa Mikako (20344351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 川井恵一 (30204663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 浅田祐士郎 (70202588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 鐙谷武雄 (80270726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 七戸秀夫 (80374479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 山下篤 (90372797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 玉木長良 (30171888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 宿里充穗 (20525571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 尾江悟 (90756107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 木村寛之 (50437240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 大島伸宏 (80508648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 水野雄貴 (90805194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 北川善政 (00224957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 粟生木美穂 (10783227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 稲波修 (10193559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 孫略 (40757704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. Abo Norifumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Higashikawa Kei 東川 桂

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生検に代わる診断法：NASH鑑別診断を可能とする新規核医学イメージング法の開発Principal Investigator

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Development of an imaging method of complement complex for the diagnosis of chronic inflammatory diseasePrincipal Investigator

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Development of a diagnostic method for nonalcoholic steatohepatitis by visualization of thymidine phosphorylasePrincipal Investigator

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[Journal Article] Preclinical investigation of potential use of thymidine phosphorylase-targeting tracer for diagnosis of nonalcoholic steatohepatitis2020

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[Journal Article] Biodistribution and radiation dosimetry of the novel hypoxia PET probe [18F]DiFA and comparison with [18F]FMISO2019

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[Journal Article] Elimination of tumor hypoxia by eribulin demonstrated by 18F-FMISO hypoxia imaging in human tumor xenograft models2019

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Higashikawa Kei 東川桂

[Presentation] Feasibility and potentials of thymidine phosphorylase (TP) as an imaging biomarker and its nuclear medicine imaging for the diagnosis of non-alcoholic　steatohepatitis.2018