HARAMA Daisuke 原間大輔

… Alternative Names

原間大輔ハラマダイスケ

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Researcher Number	10774078
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立成育医療研究センター, エコチル調査研究部, 医師研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人国立成育医療研究センター, エコチル調査研究部, 医師研究員 2019 – 2022: 山梨大学, 大学院総合研究部, 医学研究員 2016 – 2017: 山梨大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 58010:Medical management and medical sociology-related / Pediatrics Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator Lenalidomide / フィラデルフィア染色体陽性急性急性リンパ性白血病 / 急性リンパ性白血病 / レナリドミド / 急性リンパ球性白血病 / IKZF1 / 新規治療法 / 急性白血病 / フィラデルフィア染色体 Except Principal Investigator 個別化治療 … More / ゲノム編集 / 薬剤感受性 / 難治性 / 急性リンパ性白血病 / 白血病 / ゲノム編集技術 / ゲノム解析 / ゲノム情報 / がんゲノム Less

AMR対策推進を目指した抗菌薬アレルギーに対するデラベリングシステムの開発Principal Investigator
- Principal Investigator
  
  原間大輔
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  National Center for Child Health and Development
難治性急性リンパ性白血病に対するプレシジョン・メディシンを目指した多分野融合研究
- Principal Investigator
  
  犬飼岳史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Yamanashi
Integrated study aiming at development of precision medicine for poor prognostic acute lymphoblastic leukemia
- Principal Investigator
  
  Inukai Takeshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Yamanashi
Lenalidomide as IKZF1 inhibitor induces Ph+ALL cells into apoptosis synergy with antileukemic agentsPrincipal Investigator
- Principal Investigator
  
  HARAMA Daisuke
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi

All 2023 2022 2021 2020 2019 2017 2016

All Journal Article Presentation

[Journal Article] Utility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL2023
- Author(s)
  Watanabe Atsushi、Miyake Kunio、Yamada Yuriko、Sunamura Ei-Ichiro、Yotani Takuya、Kagami Keiko、Kasai Shin、Tamai Minori、Harama Daisuke、Akahane Koshi、Goi Kumiko、Sakaguchi Kimiyoshi、Goto Hiroaki、Kitahara Shinichiro、Inukai Takeshi
- Journal Title
  
  Epigenetics
  
  Volume: 18 Issue: 1 Pages: 2268814-2268814
- DOI
  10.1080/15592294.2023.2268814
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24298
[Journal Article] Generation of Philadelphia chromosome in human leukemia by DNA breaks on the BCR and ABL1 genes using CRISPR/Cas9 system.2023
- Author(s)
  Tamai M, Fujisawa S, Nguyen Thao TT, Komatsu C, Kagami K, Kamimoto K, Omachi K, Kasai S, Harama D, Watanabe A, Akahane K, Goi K, Naka K, Kaname T, Teshima T, and Inukai T
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: 30 Issue: 1 Pages: 38-50
- DOI
  10.1038/s41417-022-00522-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19353, KAKENHI-PROJECT-21K15528, KAKENHI-PROJECT-20H03517, KAKENHI-PROJECT-23K24298
[Journal Article] CRISPR/Cas9-Mediated Induction of Relapse-Specific NT5C2 and PRPS1 Mutations Confers Thiopurine Resistance as a Relapsed Lymphoid Leukemia Model2023
- Author(s)
  Nguyen Thao Thu Thi、Tanaka Yoichi、Sanada Masashi、Hosaka Masumi、Tamai Minori、Kagami Keiko、Komatsu Chiaki、Somazu Shinpei、Harama Daisuke、Kasai Shin、Watanabe Atsushi、Akahane Koushi、Goi Kumiko、Inukai Takeshi
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 103 Issue: 4 Pages: 199-210
- DOI
  10.1124/molpharm.122.000546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24298
[Journal Article] Successful treatment of intractable gastrointestinal tract graft-vs-host disease with oral beclomethasone dipropionate in pediatric and young adult patients2022
- Author(s)
  Akahane Koshi、Watanabe Atsushi、Somazu Shinpei、Harama Daisuke、Shinohara Tamao、Kasai Shin、Oshiro Hiroko、Goi Kumiko、Hasuda Norio、Ozawa Chihiro、Sugita Kanji、Inukai Takeshi
- Journal Title
  
  Medicine
  
  Volume: 101 Issue: 11
- DOI
  10.1097/md.0000000000029054
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03615
[Journal Article] Association of allele-specific methylation of the <i>ASNS</i> gene with asparaginase sensitivity and prognosis in T-ALL2022
- Author(s)
  Akahane Koshi、Kimura Shunsuke、Miyake Kunio、Watanabe Atsushi、Kagami Keiko、Yoshimura Kentaro、Shinohara Tamao、Harama Daisuke、Kasai Shin、Goi Kumiko、Kawai Tomoko、Hata Kenichiro、Kiyokawa Nobutaka、Koh Katsuyoshi、他7名
- Journal Title
  
  Blood Advances
  
  Volume: 6 Issue: 1 Pages: 212-224
- DOI
  10.1182/bloodadvances.2021004271
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07728, KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-21K19405
[Journal Article] Introduction of the T315I gatekeeper mutation of BCR/ABL1 into a Philadelphia chromosome-positive lymphoid leukemia cell line using the CRISPR/Cas9 system2022
- Author(s)
  Nguyen Thao T. T.、Tamai Minori、Harama Daisuke、Kagami Keiko、Kasai Shin、Watanabe Atsushi、Akahane Koshi、Goi Kumiko、Inukai Takeshi
- Journal Title
  
  International Journal of Hematology
  
  Volume: 116 Issue: 4 Pages: 534-543
- DOI
  10.1007/s12185-022-03369-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24298
[Journal Article] IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform2021
- Author(s)
  Harama Daisuke、Yahata Takashi、Kagami Keiko、Abe Masako、Ando Norie、Kasai Shin、Tamai Minori、Akahane Koshi、Inukai Takeshi、Kiyokawa Nobutaka、Ibrahim Abd Aziz、Ando Kiyoshi、Sugita Kanji
- Journal Title
  
  Cell Death Discovery
  
  Volume: 7 Issue: 1 Pages: 1-14
- DOI
  10.1038/s41420-021-00523-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-18K14702, KAKENHI-PROJECT-23K21386
[Journal Article] NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells2021
- Author(s)
  Somazu S, Tanaka Y, Tamai M, Watanabe A, Kagami K, Abe M, Harama D, Shinohara T, Akahane K, Goi K, Sugita K, Moriyama T, Yang J, Goto H, Minegishi M, Iwamoto S,?Takita J, Inukai T
- Journal Title
  
  J Cell Mol Med
  
  Volume: 25 Issue: 22 Pages: 10521-10533
- DOI
  10.1111/jcmm.16981
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-21K19405
[Journal Article] High prevalence of MEF2D fusion in human B-cell precursor acute lymphoblastic leukemia cell lines.2020
- Author(s)
  Akahane K, Yasuda T, Tsuzuki S, Hayakawa F, Kiyokawa N, Somazu S, Watanabe A, Kagami K, Abe M, Harama D, Goi K, Kawazu M, Kojima S, Imamura T, Goto H, Iwamoto S, Minegishi M, Abe M, Hojo H, Inaba T, Mano H, Sugita K, Inukai T.
- Journal Title
  
  Hematol Oncol.
  
  Volume: 38 Issue: 4 Pages: 614-617
- DOI
  10.1002/hon.2762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19H03615
[Journal Article] Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines.2020
- Author(s)
  Tamai M, Huang M, Kagami K, Abe M, Somazu S, Shinohara T, Harama D, Watanabe A, Akahane K, Goi K, Sugita K, Goto H, Minegishi M, Iwamoto S, Inukai T.
- Journal Title
  
  Cancer Cell Int
  
  Volume: 20 Issue: 1 Pages: 434-434
- DOI
  10.1186/s12935-020-01524-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03615
[Journal Article] High ENT1 and DCK gene expression levels are a potential biomarker to predict favorable response to nelarabine therapy in T-cell acute lymphoblastic leukemia.2019
- Author(s)
  Akahane K, Murakami Y, Kagami K, Abe M, Harama D, Shinohara T, Watanabe A, Goi K, Nishi R, Yamauchi T, Kimura S, Takita J, Look AT, Minegishi M, Sugita K, Inukai T.
- Journal Title
  
  Hematol Oncol.
  
  Volume: 37 Issue: 4 Pages: 516-519
- DOI
  10.1002/hon.2654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07294, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-18K19467
[Journal Article] Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.2019
- Author(s)
  Watanabe A, Inukai T, Kagami K, Abe M, Takagi M, Fukushima T, Fukushima H, Nanmoku T, Terui K, Ito T, Toki T, Ito E, Fujimura J, Goto H, Endo M, Look T, Kamps M, Minegishi M, Takita J, Inaba T, Takahashi H, Ohara A, Harama D, Shinohara T, Somazu S, Oshiro H, Akahane K, Goi K, Sugita K.
- Journal Title
  
  Cancer Med.
  
  Volume: 7 Issue: 11 Pages: 5274-5288
- DOI
  10.1002/cam4.2356
- NAID
  120007159553
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04039, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-18K19467
[Presentation] Ph陽性ALLにおけるインテグリンα6の発現誘導を介するラミニン接着へのBCR::ABL1の関与2023
- Author(s)
  高橋和也, Nguyen TT, 玉井望雅, 原間大輔, 笠井慎, 赤羽弘資, 合井久美子, 加賀美恵子, 小松千亜紀, 犬飼岳史
- Organizer
  第65回日本小児血液がん学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24298
[Presentation] TKI-resistance in a human Ph+ leukemia model with T315I-containing compound mutations of BCR::ABL12023
- Author(s)
  Nguyen Thao TT, Tamai Minori, Harama Daisuke, Kagami Keiko, Komatsu Chiaki, Kasai Shin, Akahane Koushi, Goi Kumiko, Inukai Takeshi
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24298
[Presentation] p210 and p190 BCR::ABL1 induce different gene expression profiles in the artificial Philadelphia chromosome-positive leukemias created by CRISPR/Cas9 system2022
- Author(s)
  Tamai Minori, Nguyen Thao, Komatsu Chiaki, Kagami Keiko, Kasai Shin, Harama Daisuke, Akahane Koshi, Goi Kumiko, Inukai Takeshi
- Organizer
  第64回日本小児血液がん学会
- Data Source
  KAKENHI-PROJECT-23K24298
[Presentation] Establishment of a human acute lymphoblastic leukemia model with relapse-specific mutation of the TP53 gene using the prime editing system2022
- Author(s)
  Nguyen Thao, Tamai Minori, Inaba Toshiya, Nagamachi Akiko, Kagami Keiko, Harama Daisuke, Kasai Shin, Akahane Koshi, Goi Kumiko, Inukai Takeshi
- Organizer
  第64回日本小児血液がん学会
- Data Source
  KAKENHI-PROJECT-23K24298
[Presentation] Establishment of thiopurine-resistant acute lymphoblastic human lymphoid leukemia models acquiring relapse-specific mutations in the PRPS1 gene using CRISPR/Cas9 system2021
- Author(s)
  Nguyen Thao, Tamai Minori, Harama Daisuke, Kagami Keiko, Kasai Shin, Watanabe Atsushi, Akahane Koshi, Goi Kumiko, Inukai Takeshi
- Organizer
  第63回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03615
[Presentation] Introduction of relapsed ALL-specific mutation in NT5C2 into lymphoid leukemia model by CRISPR/Cas92021
- Author(s)
  Nguyen Thao, Tamai Minori, Harama Daisuke, Kagami Keiko, Kasai Shin, Watanabe Atsushi, Akahane Koshi, Goi Kumiko, Inukai Takeshi
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03615
[Presentation] Induction of ponatinib-resistant T315M gatekeeper mutation into Ph+ leukemia cell lines by homologous recombination using CRISPR/Cas9 system.2019
- Author(s)
  Harama D, Inukai T, et al.
- Organizer
  第61回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03615
[Presentation] IKZF1阻害剤としてのレナリドミドは他剤との相乗作用でPh染色体陽性細胞にアポトーシスを誘導する2017
- Author(s)
  原間大輔
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19635
[Presentation] Lenalidomide Effectively Induces PhiladelphiaChromosome-Positive ALL Cellsinto Apoptosis in Synergy with Tyrosine Kinase Inhibitor2016
- Author(s)
  Daisuke Harama
- Organizer
  58th ASH Annual Meeting
- Place of Presentation
  San Diego (USA)
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19635
[Presentation] Lenalidomide induces apoptosis of Ph positive ALL cells in synergy with imatinib2016
- Author(s)
  原間　大輔
- Organizer
  第58回日本小児血液がん学会学術集会
- Place of Presentation
  品川プリンスホテル(東京・品川)
- Year and Date
  2016-12-15
- Data Source
  KAKENHI-PROJECT-16K19635

1. Inukai Takeshi (30293450)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
2. 大城浩子 (50377537)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 合井久美子 (70324192)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. 赤羽弘資 (90377531)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
5. 渡邊敦 (30610498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 篠原珠緒 (80747452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 玉井望雅 (90747453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. YAMAUCHI Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 早川文彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 本名浩子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 吉村健太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 伊藤悦朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 照井君典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 土岐力

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 仲一仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 滝田順子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARAMA Daisuke 原間 大輔

原間 大輔 ハラマ ダイスケ

Research Projects

Research Products

Co-Researchers

AMR対策推進を目指した抗菌薬アレルギーに対するデラベリングシステムの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

難治性急性リンパ性白血病に対するプレシジョン・メディシンを目指した多分野融合研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated study aiming at development of precision medicine for poor prognostic acute lymphoblastic leukemia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Lenalidomide as IKZF1 inhibitor induces Ph+ALL cells into apoptosis synergy with antileukemic agentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Utility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of Philadelphia chromosome in human leukemia by DNA breaks on the BCR and ABL1 genes using CRISPR/Cas9 system.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPR/Cas9-Mediated Induction of Relapse-Specific NT5C2 and PRPS1 Mutations Confers Thiopurine Resistance as a Relapsed Lymphoid Leukemia Model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful treatment of intractable gastrointestinal tract graft-vs-host disease with oral beclomethasone dipropionate in pediatric and young adult patients2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of allele-specific methylation of the <i>ASNS</i> gene with asparaginase sensitivity and prognosis in T-ALL2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Introduction of the T315I gatekeeper mutation of BCR/ABL1 into a Philadelphia chromosome-positive lymphoid leukemia cell line using the CRISPR/Cas9 system2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High prevalence of MEF2D fusion in human B-cell precursor acute lymphoblastic leukemia cell lines.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High ENT1 and DCK gene expression levels are a potential biomarker to predict favorable response to nelarabine therapy in T-cell acute lymphoblastic leukemia.2019

HARAMA Daisuke 原間大輔

原間大輔ハラマダイスケ