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Komura Daisuke  河村 大輔

Researcher Number 10776082
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-0038-728X
Affiliation (Current) 2025: 東京大学, 大学院医学系研究科(医学部), 講師
Affiliation (based on the past Project Information) *help 2021 – 2024: 東京大学, 大学院医学系研究科(医学部), 助教
2018 – 2019: 東京大学, 大学院医学系研究科(医学部), 助教
2016 – 2018: 東京医科歯科大学, 難治疾患研究所, 助教
Review Section/Research Field
Principal Investigator
Basic Section 90130:Medical systems-related / Medical genome science / Tumor diagnostics
Except Principal Investigator
Basic Section 42040:Laboratory animal science-related / Laboratory animal science
Keywords
Principal Investigator
癌 / がん / ゲノム / デジタル病理画像 / 深層学習 / 病理組織画像 / がん間質相互作用 / シングルセルトランスクリプトーム / がん-間質細胞間相互作用 / 治療標的 / 病理学 / 機械学習 / 遺伝子変異 … More
Except Principal Investigator
… More 上皮間葉転換 / インタラクトーム / インタラクト―ム / PDX / 膵癌 / ZNF185 Less
  • Research Projects

    (5 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (9 People)
  •  Construction of a large-scale analysis platform for cancer histopathology using deep texture representationPrincipal Investigator

    • Principal Investigator
      河村 大輔
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90130:Medical systems-related
    • Research Institution
      The University of Tokyo
  •  胸腔系浸潤肺癌PDXのCASTIN解析によるがん幹細胞いかり分子機構の解明

    • Principal Investigator
      千々和 剛
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42040:Laboratory animal science-related
    • Research Institution
      Jichi Medical University
  •  Single cell interactome analysis for the discovery of targets to overcome anti-cancer drug resistance.Principal Investigator

    • Principal Investigator
      Komura Daisuke
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Medical genome science
    • Research Institution
      The University of Tokyo
      Tokyo Medical and Dental University
  •  Deep Learningを用いたデジタル病理画像からの遺伝子変異推定Principal Investigator

    • Principal Investigator
      河村 大輔
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Tumor diagnostics
    • Research Institution
      Tokyo Medical and Dental University
  •  The analyses of epithelial-mesenchymal transition associating with LIM protein family ZNF185 using in vivo liver metastasis mouse models of the human pancreas cancer.

    • Principal Investigator
      FURUKAWA Daisuke
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Tokai University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book

  • [Book] 遺伝統計学と疾患ゲノムデータ解析 : 病態解明から個別化医療, ゲノム創薬まで2018

    • Author(s)
      岡田 随象(編集)、河村大輔ら
    • Total Pages
      264
    • Publisher
      メディカルドゥ
    • ISBN
      9784944157631
    • Data Source
      KAKENHI-PROJECT-17H04992
  • [Book] 遺伝統計学と疾患ゲノムデータ解析2018

    • Author(s)
      岡田随象(編集)、河村大輔、石川俊平ら
    • Total Pages
      272
    • Publisher
      メディカルドゥ
    • ISBN
      4944157630
    • Data Source
      KAKENHI-PROJECT-17H04992
  • [Journal Article] SegRep: Mask-Based Self-Supervised Learning for Segment Representation in Pathology Images2024

    • Author(s)
      Yang Chichun、Komura Daisuke、Kakiuchi Miwako、Ochi Mieko、Katoh Hiroto、Ushiku Tetsuo、Ishikawa Shumpei
    • Journal Title

      TechRxiv

      Volume: -

    • DOI

      10.36227/techrxiv.170775482.23404242/v1

    • Open Access
    • Data Source
      KAKENHI-PROJECT-23KJ0439, KAKENHI-PROJECT-23K21859
  • [Journal Article] Restaining-based annotation for cancer histology segmentation to overcome annotation-related limitations among pathologists.2023

    • Author(s)
      Komura D, Onoyama T, Shinbo K, Odaka H, Hayakawa M, Ochi M, Herdiantoputri RR, Endo H, Katoh H, Ikeda T, Ushiku T, Ishikawa S.
    • Journal Title

      Patterns

      Volume: 4(2) Issue: 2 Pages: 100688-100688

    • DOI

      10.1016/j.patter.2023.100688

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22H04990, KAKENHI-PROJECT-23K21859
  • [Journal Article] Deep texture representation analysis for histopathological images2023

    • Author(s)
      Herdiantoputri Ranny Rahaningrum、Komura Daisuke、Fujisaka Kei、Ikeda Tohru、Ishikawa Shumpei
    • Journal Title

      STAR Protocols

      Volume: 4 Issue: 2 Pages: 102161-102161

    • DOI

      10.1016/j.xpro.2023.102161

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Journal Article] Head and Neck Tumor Histopathological Image Representation with Pr with Pre- Trained Conv ained Convolutional Neur olutional Neural Network and Vision al Network and Vision Transformer2023

    • Author(s)
      Rahaningrum Herdiantoputri Ranny、Komura Daisuke、Ikeda Tohru、Ishikawa Shumpei
    • Journal Title

      Journal of Dentistry Indonesia

      Volume: 30 Issue: 1 Pages: 41-47

    • DOI

      10.14693/jdi.v30i1.1501

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Journal Article] Universal encoding of pan-cancer histology by deep texture representations2022

    • Author(s)
      Komura Daisuke、Kawabe Akihiro、Fukuta Keisuke、et al.
    • Journal Title

      Cell Reports

      Volume: 38 Issue: 9 Pages: 110424-110424

    • DOI

      10.1016/j.celrep.2022.110424

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Journal Article] Advanced deep learning applications in diagnostic pathology2021

    • Author(s)
      KOMURA Daisuke、ISHIKAWA Shumpei
    • Journal Title

      Translational and Regulatory Sciences

      Volume: 3 Issue: 2 Pages: 36-42

    • DOI

      10.33611/trs.2021-005

    • NAID

      130008066894

    • ISSN
      2434-4974
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Journal Article] Novel targets identified by integrated cancer-stromal interactome analysis of pancreatic adenocarcinoma.2020

    • Author(s)
      Hiroshima Y, Kasajima R, Kimura Y, Komura D, Ishikawa S, Ichikawa Y, Bouvet M, Yamamoto N, Oshima T, Morinaga S, Singh SR, Hoffman RM, Endo I, Miyagi Y.
    • Journal Title

      Cancer Lett.

      Volume: 469 Pages: 217-227

    • DOI

      10.1016/j.canlet.2019.10.031

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02481, KAKENHI-PROJECT-17H04992, KAKENHI-PROJECT-19K09181, KAKENHI-PROJECT-19H03774
  • [Journal Article] High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer.2020

    • Author(s)
      Ohkuma R, Yada E, Ishikawa S, Komura D, Ishizaki H, Tamada K, Kubota Y, Hamada K, Ishida H, Hirasawa Y, Ariizumi H, Satoh E, Shida M, Watanabe M, Onoue R, Ando K, Tsurutani J, Yoshimura K, Yokobori T, Sasada T, Aoki T, Murakami M, Norose T, Ohike N, Takimoto M, Izumizaki M, Kobayashi S, Tsunoda T, Wada S.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 1 Pages: e0226707-e0226707

    • DOI

      10.1371/journal.pone.0226707

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08610, KAKENHI-PROJECT-19K07320, KAKENHI-PROJECT-19K12848, KAKENHI-PROJECT-17H04278, KAKENHI-PROJECT-17H04992, KAKENHI-PROJECT-18K19490, KAKENHI-PROJECT-20K17001
  • [Presentation] Subtype-level Segmentation Model for Inflammatory Cells in H&E images2024

    • Author(s)
      Mieko Ochi, Daisuke Komura, Shumpei Ishikawa
    • Organizer
      USCAP 113th Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Presentation] H&E染色組織画像における腫瘍微小環境解析のためのセグメンテーションモデル2024

    • Author(s)
      越智三枝子、河村大輔、石川俊平
    • Organizer
      第113回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Presentation] Large-scale histological image dataset with various H&E stain conditions and devices including smartphone for the robust model development2023

    • Author(s)
      Mieko Ochi, Daisuke Komura, Shumpei Ishikawa
    • Organizer
      19th European Congress on Digital Pathology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Presentation] 同一標本に対するH&E染色と免疫染色を利用した細胞セグメンテーションのための癌病理組織像データセットの開発2022

    • Author(s)
      河村大輔; 斧山匠; 新保幸輝; 小高滉人; 遠藤春哉; 越智三枝子; 加藤洋人; 牛久哲男; 石川俊平
    • Organizer
      第68回日本病理学会 秋季特別総会
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Presentation] ディープラーニングを用いた細胞セグメンテーションのための癌病理組織画像データセット2022

    • Author(s)
      河村大輔; 斧山巧; 新保幸輝; 小高滉人; 遠藤春哉; 越智三枝子; 加藤洋人; 牛久哲男; 石川俊平
    • Organizer
      The 81st Annual Meeting of the Japanese Cancer Association
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Presentation] 深層ニューラルネットワークによるがん病理組織形態の数値化2022

    • Author(s)
      河村大輔
    • Organizer
      第47回レーザ顕微鏡研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Presentation] Large-scale histological image dataset with various stain conditions and scanners for the robust machine learning model development2022

    • Author(s)
      Ochi, Mieko; Komura, Daisuke; Ishikawa, Shumpei
    • Organizer
      The First Workshop on Applications of Medical AI in MICCAI
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Presentation] 深層学習を用いた腫瘍組織の網羅的細胞セグメンテーション2022

    • Author(s)
      河村大輔; 斧山巧; 新保幸輝; 小高滉人; 遠藤春哉; 越智美恵子; 加藤洋人; 牛久哲男; 石川俊平
    • Organizer
      第111回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Presentation] 頭頸部腫瘍の病理画像解析とAI病理診断補助システムの構築2021

    • Author(s)
      河村大輔、石川俊平
    • Organizer
      第110回日本病理学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K21859
  • [Presentation] The genomic profile of metastatic diffuse-type gastric cancer in Cdh1loxP/loxP; Trp53loxP/loxP double conditional knockout mice2020

    • Author(s)
      Menghua Zhang, Itsuki Sugita, Daisuke Komura, Shunpei Ishikawa
    • Organizer
      第90回 日本衛生学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H04992
  • [Presentation] Single-cell transcriptomics of a model mouse for diffuse-type gastric cancer reveal ligand-receptor interactions potentially important for the cancer development2020

    • Author(s)
      古久保宙希、河村大輔、加藤洋人、石川俊平
    • Organizer
      第20回 東京大学生命科学シンポジウム
    • Data Source
      KAKENHI-PROJECT-17H04992
  • [Presentation] The genomic profile of metastatic diffuse-type gastric cancer in Cdh1loxP/loxP; Trp53loxP/loxP double conditional knockout mice2019

    • Author(s)
      Menghua Zhang, Itsuki Sugita, Daisuke Komura, Shunpei Ishikawa
    • Organizer
      第42回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17H04992
  • [Presentation] 膵癌における包括的癌-間質インタラクトーム解析2019

    • Author(s)
      廣島, 幸彦; 笠島, 理加; 木村, 弥生; 河村, 大輔; 石川, 俊平; 市川, 靖史; 遠藤, 格; 宮城, 洋平
    • Organizer
      日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H04992
  • [Presentation] Visualizing ligand-receptor-mediated interactome in single cell transcriptome data2019

    • Author(s)
      Daisuke Komura, Ryohei Suzuki, Shumpei Ishikawa
    • Organizer
      Cold Spring Harbor Laboratory Meeting, Systems Immunology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04992
  • [Presentation] Interactome analysis of gastric cancer microenvironment by single-cell transcriptome sequencing2019

    • Author(s)
      Shumpei Ishikawa, Daisuke Komura, Ryohei Suzuki, Hiroto Katoh
    • Organizer
      Cell Symbosia. Single Cells: Technology to Biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04992
  • [Presentation] Lymphotoxin-alpha plays key roles in lymphoproliferative lesions arising in patient-derived cancer2018

    • Author(s)
      TSUYOSHI CHIJIWA, DAISUKE KOMURA, MIZUHA HARAGUCHI, HARUO HASHIMOTO, HIROSHI SUEMIZU, MAKOTO KATAYAMA, YOSHIYASU NAKAMURA, DAISUKE FURUKAWA, TAKAYUKI ISAGAWA, HIROTO KATO, TAKASHI MORIYA, SHUMPEI ISHIKAWA, MASATO NAKAMURA, YOHEI MIYAGI
    • Organizer
      AACR Annual Meeting 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07096
  • [Presentation] 治療標的探索のためのがん-間質細胞間相互作用解析システム2017

    • Author(s)
      河村大輔, 砂河孝行, 鈴木良平, 佐藤玲子, 加藤洋人, 田中麻理子, 山本尚吾, 深山正久, 油谷浩幸, 石川俊平
    • Organizer
      第106回 日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-17H04992
  • [Presentation] CASTIN: a system for comprehensive analysis of cancer-stromal interactome.2017

    • Author(s)
      Daisuke Komura, Takayuki Isagawa, Ryohei Suzuki, Reiko Sato, Mariko Tanaka, Shogo Yamamoto, Masashi Fukayama, Hiroyuki Aburatani, Shumpei Ishikawa.
    • Organizer
      The 12th International Workshop on Advanced Genomics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04992
  • [Presentation] Single cell analysis for the human gastric cancer environments2017

    • Author(s)
      Hiroto Katoh, Daisuke Komura, Shumpei Ishikawa.
    • Organizer
      Cold Spring Harbor Laboratory Meeting, Single Cell Analyses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04992
  • [Presentation] An interactome analysis for personalized chemotherapy using PDX/NOG models of non-small cell lung cancer2017

    • Author(s)
      Chijiwa T, Komura D, Haraguchi M, Noguchi A, Sato H, Ito H, Nakayama H, Katayama M, Miyao N, Matsui N, Tateishi Y, Suemizu H, Nakamura Y, Furukawa D, Isagawa T, Katoh H, Moriya T, Ishikawa S, Nakamura M, Miyagi Y
    • Organizer
      AACR Annual Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07096
  • [Presentation] 治療標的探索のためのがんー間質細胞間相互作用の網羅的解析2017

    • Author(s)
      河村大輔, 鈴木良平, 加藤洋人, 山本尚吾, 油谷浩幸, 石川俊平
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H04992
  • [Presentation] The possibility of personalized chemotherapy for non-small cell lung cancer using interactome analyses of PDX/NOG models2017

    • Author(s)
      Chijiwa T, Komura D, Haraguchi M, Noguchi A, Sato H, Ito H, Nakayama H, Katayama M, Miyao N, Suemizu H, Nakamura Y, Furukawa D, Moriya T, Isagawa T, Katoh H, Ishikawa S, Nakamura M, Miyagi Y
    • Organizer
      ESMO Asia 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07096
  • [Presentation] The prevention of lymphoproliferative lesions arising in patient-derived cancer enografts by anti-graft-versus-host-disease agents2017

    • Author(s)
      Chijiwa T, Noguchi A, Komura D, Katayama M, Haraguchi M, Hashimoto H, Suemizu H, Nakamura Y, Furukawa D, Isagawa T, Katoh H, Moriya T, Ishikawa S, Nakamura M, Miyagi Y
    • Organizer
      AACR Advances in Modeling Cancer in Mice: Technology, Biology, and Beyond
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07096
  • [Presentation] Pathology Map: an Effective GUI Annotation System for Classification of Digital Pathological Images in Deep Learning2016

    • Author(s)
      Ken Tominaga, Daisuke Komura, Shumpei Ishikawa
    • Organizer
      15th European Conference on Computational Biology
    • Place of Presentation
      Hague, Netherlands
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06766
  • [Presentation] Learning High-level Features of Pathology Images using Multi-Resolution Convolutional Auto-Encoders.2016

    • Author(s)
      Ryohei Suzuki, Daisuke Komura, Shumpei Ishikawa
    • Organizer
      15th European Conference on Computational Biology
    • Place of Presentation
      Hague, Netherlands
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06766
  • 1.  千々和 剛 (70642180)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 2.  FURUKAWA Daisuke (70459478)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 3.  NAKAMURA Masato (00164335)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 4.  平岡 伸介 (40276217)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  鈴木 涼平 (30621809)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  宮城 洋平 (00254194)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  USHIKU Tetsuo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  石川 俊平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 9.  和田 聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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