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Murase Hirotaka  村瀬 裕貴

Researcher Number 10814486
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-5747-191X
Affiliation (Current) 2025: 崇城大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help 2023 – 2024: 崇城大学, 薬学部, 助教
2021 – 2022: 長崎国際大学, 薬学部, 特任助教
2020: 長崎国際大学, 薬学部, 博士研究員
2019: 名古屋大学, 理学研究科, 特任助教
2018: 名古屋大学, 理学研究科, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 37010:Bio-related chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Except Principal Investigator
Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords
Principal Investigator
低分子リガンド / RNA / 化学修飾 / 転移修飾核酸 / N4-acetylcytidine (ac4C) / 核酸化学 / 合成後修飾 / アセチル化剤 / 6-Thioguanine / 反応性オリゴ核酸 … More / 官能基転移 / RNA部位特異的化学修飾 / 生体機能分子 / RNAヘアピンループ / 疾患関連リピート配列 / G-clamp / 核酸アナログ / リピートRNA / RNA構造変化 / RNA構造変換 / ステム-ループ構造 / グアニン4重鎖 / repeat expansion disease / CGG repeat RNA / RNA構造変化誘起剤 / 機能性分子 / 脆弱X関連振戦/失調症候群(FXTAS) / G-quadruplex / リピート病 / RNA構造変化誘起 / 低分子G-clamp / G4重鎖 / ステム-ループ / G-Gミスマッチ / CGGリピートRNA / RNA高次構造 / RNA結合性低分子 / 蛍光ON型プローブ / 縮合反応 / 多機能化 / コンジュゲーション / 新規RNA結合分子 / 蛍光プローブ / pre-miRNA / RNA 高次構造 / 水素結合 / 分子認識 … More
Except Principal Investigator
ナンセンス変異 / 未熟停止コドン / リードスルー / 化学修飾mRNA / 核酸医薬 / FMR1 / 遺伝子発現促進 / 分子集積薬 / 低分子リガンド / CGGリピー / 翻訳活性化 / 転写活性化 / 低分子創薬 / CGGリピート / FMR1遺伝子 / リピート病 / 脆弱X症候群 Less
  • Research Projects

    (5 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (7 People)
  •  Basic research into nucleic acid drugs that induce readthrough by chemically modifying the adenosine at the premature termination codon

    • Principal Investigator
      佐々木 茂貴
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Nagasaki International University
  •  シトシンN4位の部位特異的アシル基修飾法の開発Principal Investigator

    • Principal Investigator
      村瀬 裕貴
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Sojo University
  •  Development of small molecule drugs for fragile X syndrome based on ligands that cooperatively accumulate on the CGG repeats.

    • Principal Investigator
      佐々木 茂貴
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Nagasaki International University
  •  Development of small molecular ligands that bind to repeat RNA and induce a conformational change of RNA higher-order structurePrincipal Investigator

    • Principal Investigator
      Murase Hirotaka
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 37010:Bio-related chemistry
    • Research Institution
      Nagasaki International University
  •  Development of the recognition molecules for pre-miRNA based on the hydrogen bondingPrincipal Investigator

    • Principal Investigator
      Murase Hirotaka
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 37010:Bio-related chemistry
    • Research Institution
      Nagoya University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

  • [Journal Article] Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA2023

    • Author(s)
      Murase Hirotaka、Lee Jeongsu、Taniguchi Yosuke、Sasaki Shigeki
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 71 Issue: 1 Pages: 64-69

    • DOI

      10.1248/cpb.c22-00738

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2023-01-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K15398, KAKENHI-PROJECT-23K27301
  • [Journal Article] Development of a selective ligand for G-G mismatches of CGG repeat RNA inducing the RNA structural conversion from the G-quadruplex into a hairpin-like structure2022

    • Author(s)
      Murase Hirotaka, Nagatsugi Fumi, Sasaki Shigeki
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 20 Issue: 16 Pages: 3375-3381

    • DOI

      10.1039/d2ob00279e

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K15398, KAKENHI-PROJECT-20H02855, KAKENHI-PROJECT-21K19038
  • [Journal Article] Application of the Functionality Transfer Oligodeoxynucleotide for the Site-Selective Modification of RNA with a Divers Molecule2022

    • Author(s)
      Togo N., Murase H., Lee J., Taniguchi Y. and Sasaki S.
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 70 Issue: 7 Pages: 498-504

    • DOI

      10.1248/cpb.c22-00288

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2022-07-01
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03351, KAKENHI-PROJECT-20K15398
  • [Journal Article] Artificial Host Molecules to Covalently Capture 8-Nitro-cGMP in Neutral Aqueous Solutions and in Cells2021

    • Author(s)
      Y. Fuchi, H. Murase, R. Kai, K. Kurata, S. Karasawa, and S. Sasaki*
    • Journal Title

      Bioconjugate Chem

      Volume: 32 Issue: 2 Pages: 385-393

    • DOI

      10.1021/acs.bioconjchem.1c00012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07016, KAKENHI-PROJECT-20K15398, KAKENHI-PROJECT-20K15963, KAKENHI-PROJECT-18H02558
  • [Journal Article] Protection of all cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme, indicative of simultaneous binding of small ligands2020

    • Author(s)
      Murase Hirotaka、Wakisaka Gentaro、Noguchi Tomoharu、Sasaki Shigeki
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 28 Issue: 20 Pages: 115730-115730

    • DOI

      10.1016/j.bmc.2020.115730

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K15398, KAKENHI-PROJECT-18H02558
  • [Journal Article] 核酸の高次構造・特殊配列に結合する低分子化合物-基盤分子の開発/評価法の構築-2020

    • Author(s)
      村瀬 裕貴
    • Journal Title

      日本核酸化学会誌

      Volume: 4 Pages: 15-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K15398
  • [Journal Article] Development of the binding molecules for the RNA higher-order structures based on the guanine-recognition by the G-clamp2019

    • Author(s)
      Murase Hirotaka、Nagatsugi Fumi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Issue: 11 Pages: 1320-1324

    • DOI

      10.1016/j.bmcl.2019.03.052

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K14330, KAKENHI-PLANNED-15H05838
  • [Patent] 核酸の部位特異的アシル修飾剤2023

    • Inventor(s)
      村瀬 裕貴
    • Industrial Property Rights Holder
      学校法人 君が淵学園
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-112639
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-23K06064
  • [Presentation] CGGリピート配列への低分子集積によるFMR1遺伝子の転写活性化2024

    • Author(s)
      村瀬 裕貴、川久保 厚佑、塩田 倫史、佐々木 茂貴
    • Organizer
      日本薬学会第143回年会
    • Data Source
      KAKENHI-PROJECT-23K21354
  • [Presentation] CGGリピート関連疾患に対する低分子創薬2024

    • Author(s)
      村瀬 裕貴、塩田 倫史、佐々木 茂貴
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-23K06064
  • [Presentation] CGGリピート関連疾患に対する低分子創薬2024

    • Author(s)
      村瀬 裕貴、塩田 倫史、佐々木 茂貴
    • Organizer
      日本薬学会第143回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K21354
  • [Presentation] Study on read-through of premature termination codon by site-specific chemical modification2023

    • Author(s)
      Jeongsu Lee, Hirotaka Murase, Norihiro Togo, Yosuke Taniguchi, Shigeki Sasaki
    • Organizer
      The 50th International Symposium on Nucleic Acids Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K21354
  • [Presentation] 部位特異的化学修飾法を基盤としたRNAの分子修飾とラベル化2023

    • Author(s)
      村瀬 裕貴、都甲 典弘、李 政洙、谷口 陽祐、佐々木 茂貴
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-20K15398
  • [Presentation] Development of new oligonucleotide agents for site specific RNA acetylation2023

    • Author(s)
      Hirotaka Murase, Jeongsu Lee, Yosuke Taniguchi, Shuhei Imoto, Shigeki Sasaki
    • Organizer
      The 50th international Symposium on Nucleic Acids Chemistry (ISNAC)
    • Data Source
      KAKENHI-PROJECT-23K06064
  • [Presentation] Read-through of the premature-termination codon (PTC) based on the site-specific chemical modifications of mRNA2023

    • Author(s)
      Hirotaka Murase, Jeongsu Lee, Yosuke Taniguchi, Shigeki Sasaki
    • Organizer
      日本核酸医薬学会第8回年会
    • Data Source
      KAKENHI-PROJECT-23K06064
  • [Presentation] mRNAの部位特異的分子修飾による未熟終止コドン(PTC)のリードスルー2023

    • Author(s)
      村瀬 裕貴、李 政洙、谷口 陽祐、佐々木 茂貴
    • Organizer
      核酸医薬学会第8回年会
    • Data Source
      KAKENHI-PROJECT-23K21354
  • [Presentation] Development of a new oligonucleotide agent for site-specific RNA acetylation2023

    • Author(s)
      Hirotaka Murase, Jeongsu Lee, Yosuke Taniguchi, Shuhei Imoto, Shigeki Sasaki
    • Organizer
      The 50th International Symposium on Nucleic Acids Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K21354
  • [Presentation] Development of a small-molecule inducer that converts the G-quadruplex structure of CGG repetitive RNA to a hairpin form2022

    • Author(s)
      Hirotaka Murase, Fumi Nagatsugi, Shigeki Sasaki
    • Organizer
      The 49th international Symposium on Nucleic Acids Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15398
  • [Presentation] CGGリピートRNAの構造変換を誘起する1,3-diazaphenoxazine誘導体の開発2022

    • Author(s)
      村瀬 裕貴、永次 史、佐々木 茂貴
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-20K15398
  • [Presentation] 天然及び人工核酸の部位特異的化学修飾とその応用2022

    • Author(s)
      村瀬 裕貴、 都甲 典弘、李 政洙、谷口 陽祐、 佐々木 茂貴
    • Organizer
      日本核酸医薬学会 第7回年会
    • Data Source
      KAKENHI-PROJECT-20K15398
  • [Presentation] CGGリピートRNAの構造変換を誘起する1,3-diazaphenoxazine誘導体の開発2022

    • Author(s)
      村瀬 裕貴、永次 史、佐々木 茂貴
    • Organizer
      日本薬学会 第142年会
    • Data Source
      KAKENHI-PROJECT-23K21354
  • [Presentation] RNAの高次構造変化を誘起する新規低分子リガンドの開発2021

    • Author(s)
      村瀬 裕貴、永次 史、佐々木 茂貴
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-20K15398
  • [Presentation] CGG-リピートRNA に結合する低分子型G-clamp 誘導体の開発2021

    • Author(s)
      村瀬 裕貴、永次 史、佐々木 茂貴
    • Organizer
      日本ケミカルバイオロジー学会 第15回年会
    • Data Source
      KAKENHI-PROJECT-20K15398
  • [Presentation] CGG-リピートRNA に結合する低分子型G-clamp 誘導体の開発2021

    • Author(s)
      村瀬裕貴、永次史、佐々木茂貴
    • Organizer
      日本ケミカルバイオロジー学会 第15回年会
    • Data Source
      KAKENHI-PROJECT-23K21354
  • [Presentation] Development of the small molecular binder for the r(CGG) repeat2021

    • Author(s)
      Hirotaka Murase, Fumi Nagatsugi, Shigeki Sasaki
    • Organizer
      IS3NA-IRT Virtual Symposium 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15398
  • [Presentation] リピートDNA配列中の複数連続する結合サイトに協奏的に全サイト結合する低分子リガンドの開発2020

    • Author(s)
      村瀬 裕貴、脇坂 元太郎、野口 幹晴、 Ting Wu、 佐々木 茂貴
    • Organizer
      反応と合成の進歩2020特別企画シンポジウム
    • Data Source
      KAKENHI-PROJECT-20K15398
  • [Presentation] G-clampによるグアニン認識を基本としたRNA高次構造結合性低分子リガンドの開発2019

    • Author(s)
      村瀬 裕貴、永次 史
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K14330
  • [Presentation] 1,3-ジアザフェノキサジン環によるグアニン認識を利用したRNA高次構造検出プローブの開発2018

    • Author(s)
      村瀬 裕貴、永次 史
    • Organizer
      日本ケミカルバイオロジー学会第13回年会
    • Data Source
      KAKENHI-PROJECT-18K14330
  • [Presentation] Development of small molecular G-clamp derivatives binding to RNA higher-order structure2018

    • Author(s)
      Hirotaka Murase, Fumi Nagatsugi
    • Organizer
      The 45th International Symposium on Nucleic Acids Chemistry 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14330
  • [Presentation] 制限酵素阻害アッセイによるChromomycin A3の繰り返しDNAに対する同時結合性の評価2018

    • Author(s)
      村瀬 裕貴、野口 幹晴、脇坂 元太郎、Ting Wu、佐々木 茂貴
    • Organizer
      第60回天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-18K14330
  • [Presentation] Development of fluorescent probe for RNA higher-order structure2018

    • Author(s)
      Hirotaka Murase, Fumi Nagatsugi
    • Organizer
      The 23rd International Roundtable on Nucleosides, Nucleotides and Nucleic acids
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14330
  • 1.  佐々木 茂貴 (10170672)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 2.  塩田 倫史 (00374950)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  山田 耕平 (40583232)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  吉田 達貞 (80527557)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  西奥 剛 (90435115)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  唐沢 悟
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  渕 靖史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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