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TSUYAMA TOMONORI  津山 友徳

ORCIDConnect your ORCID iD *help
Researcher Number 10845960
Other IDs
Affiliation (Current) 2025: 熊本大学, 大学院生命科学研究部(医), 助教
Affiliation (based on the past Project Information) *help 2022 – 2024: 熊本大学, 大学院生命科学研究部(医), 助教
2020 – 2021: 熊本大学, 大学院生命科学研究部(医), 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 54040:Metabolism and endocrinology-related
Except Principal Investigator
Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Basic Section 54040:Metabolism and endocrinology-related
Keywords
Principal Investigator
膵β細胞 / 低酸素 / β細胞 / 老化 / 転写抑制 / ミトコンドリア / インスリン分泌 / 糖尿病
Except Principal Investigator
シングルセル解析 / エピゲノム … More / インスリン分泌 / β細胞 / 老化 / FGF21 / 寿命 / IMP2 / 褐色脂肪細胞 / 糖新生 / 糖尿病 / SIRT7 / サーチュイン Less
  • Research Projects

    (5 results)
  • Research Products

    (14 results)
  • Co-Researchers

    (4 People)
  •  加齢による膵β細胞個性喪失の分子機構の解明Principal Investigator

    • Principal Investigator
      津山 友徳
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Kumamoto University
  •  Elucidation of molecular mechanism of age-associated impaired insulin secretion by single cell analysis

    • Principal Investigator
      山縣 和也
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Kumamoto University
  •  Hypoxic response by BHLHE40 and PHD3 in pancreatic beta cellsPrincipal Investigator

    • Principal Investigator
      Tsuyama Tomonori
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Kumamoto University
  •  Regulation of glucose metabolism by SIRT7

    • Principal Investigator
      山縣 和也
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Kumamoto University
  •  The role of PHD3 in hypoxic response of pancreatic beta cellsPrincipal Investigator

    • Principal Investigator
      TSUYAMA TOMONORI
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Kumamoto University

All 2024 2023 2022 2020

All Journal Article Presentation

  • [Journal Article] Roles of β-Cell Hypoxia in the Progression of Type 2 Diabetes2024

    • Author(s)
      Yamagata Kazuya、Tsuyama Tomonori、Sato Yoshifumi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 8 Pages: 4186-4186

    • DOI

      10.3390/ijms25084186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K18302, KAKENHI-PROJECT-23K24388
  • [Journal Article] Hypoxia causes pancreatic β‐cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE402023

    • Author(s)
      Tsuyama Tomonori、Sato Yoshifumi、Yoshizawa Tatsuya、Matsuoka Takaaki、Yamagata Kazuya
    • Journal Title

      EMBO reports

      Volume: 24 Issue: 8

    • DOI

      10.15252/embr.202256227

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K18302, KAKENHI-PROJECT-22K08658, KAKENHI-PROJECT-22K16399, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K24388
  • [Journal Article] SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice2022

    • Author(s)
      Mizumoto Tomoya、Yoshizawa Tatsuya、Sato Yoshifumi、Ito Takaaki、Tsuyama Tomonori、Satoh Akiko、Araki Satoshi、Tsujita Kenichi、Tamura Masaru、Oike Yuichi、Yamagata Kazuya
    • Journal Title

      Cells

      Volume: 11 Issue: 22 Pages: 3609-3609

    • DOI

      10.3390/cells11223609

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08658, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-22K16399, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H04107, KAKENHI-PROJECT-23K24388, KAKENHI-PROJECT-23K24805
  • [Journal Article] SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice2022

    • Author(s)
      Yoshizawa Tatsuya、Sato Yoshifumi、Sobuz Shihab U.、Mizumoto Tomoya、Tsuyama Tomonori、Karim Md. Fazlul、Miyata Keishi、Tasaki Masayoshi、Yamazaki Masaya、Kariba Yuichi、Araki Norie、Araki Eiichi、Kajimura Shingo、Oike Yuichi、Braun Thomas、Bober Eva、Auwerx Johan、Yamagata Kazuya
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 7439-7439

    • DOI

      10.1038/s41467-022-35219-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08533, KAKENHI-PROJECT-22K08187, KAKENHI-PROJECT-22K08658, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-22K16399, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H04107, KAKENHI-PROJECT-23K24388, KAKENHI-PROJECT-19H03772, KAKENHI-PROJECT-22F22111
  • [Journal Article] Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes2020

    • Author(s)
      Kariba Yuichi、Yoshizawa Tatsuya、Sato Yoshifumi、Tsuyama Tomonori、Araki Eiichi、Yamagata Kazuya
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 530 Issue: 3 Pages: 500-507

    • DOI

      10.1016/j.bbrc.2020.05.090

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09008, KAKENHI-PROJECT-20K17538, KAKENHI-PROJECT-19H03711, KAKENHI-PROJECT-18K08482, KAKENHI-PROJECT-19K22639, KAKENHI-PROJECT-16H06276
  • [Journal Article] HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT12020

    • Author(s)
      Sato Yoshifumi、Rahman Md Mostafizur、Haneda Masaki、Tsuyama Tomonori、Mizumoto Tomoya、Yoshizawa Tatsuya、Kitamura Tadahiro、Gonzalez Frank J.、Yamamura Ken-ichi、Yamagata Kazuya
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

      Volume: 1866 Issue: 11 Pages: 165898-165898

    • DOI

      10.1016/j.bbadis.2020.165898

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09008, KAKENHI-PROJECT-20K17538, KAKENHI-PROJECT-19H03711, KAKENHI-PROJECT-19K22639, KAKENHI-PROJECT-16H06276
  • [Presentation] 低酸素誘導性インスリン分泌不全の分子機構の解明2023

    • Author(s)
      津山友徳、佐藤叔史、松岡孝昭、山縣和也
    • Organizer
      第61回日本糖尿病学会九州地方会
    • Data Source
      KAKENHI-PROJECT-23K18302
  • [Presentation] 脱アセチル化酵素SIRT7による肝糖新生制御機構の解明2023

    • Author(s)
      水本智也、佐藤叔史、津山友徳、山縣和也
    • Organizer
      第61回日本糖尿病学会九州地方会
    • Data Source
      KAKENHI-PROJECT-23K18302
  • [Presentation] 膵β細胞における低酸素誘導因子ATF3の役割2023

    • Author(s)
      佐藤叔史、津山友徳、山縣和也
    • Organizer
      第61回日本糖尿病学会九州地方会
    • Data Source
      KAKENHI-PROJECT-23K24388
  • [Presentation] 低酸素誘導性インスリン分泌不全の分子機構の解明2023

    • Author(s)
      津山友徳、佐藤叔史、松岡孝昭、山縣和也
    • Organizer
      第61回日本糖尿病学会九州地方会
    • Data Source
      KAKENHI-PROJECT-23K24388
  • [Presentation] 脱アセチル化酵素SIRT7による肝糖新生制御機構の解明2023

    • Author(s)
      水本智也、佐藤叔史、津山友徳、山縣和也
    • Organizer
      第61回日本糖尿病学会九州地方会
    • Data Source
      KAKENHI-PROJECT-23K24388
  • [Presentation] 低酸素誘導性インスリン分泌不全の分子機構の解明2023

    • Author(s)
      津山友徳
    • Organizer
      第61回日本糖尿病学会九州地方会
    • Data Source
      KAKENHI-PROJECT-22K16399
  • [Presentation] 膵β細胞における低酸素誘導因子ATF3の役割2023

    • Author(s)
      佐藤叔史、津山友徳、山縣和也
    • Organizer
      第61回日本糖尿病学会九州地方会
    • Data Source
      KAKENHI-PROJECT-23K18302
  • [Presentation] 日本人の加齢による2型糖尿病発症機序の解明(合志スタディ)2023

    • Author(s)
      羽根田昌樹、福田一起、宮川克俊、清原由紀夫、古賀荒太郎、水流添 覚、古川昇、津山友徳、阪口雅司、瀬ノ口隆文、松村剛、山縣和也、荒木栄一
    • Organizer
      第66回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-23K24388
  • 1.  山縣 和也 (70324770)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 2.  佐藤 叔史 (90622598)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 3.  吉澤 達也 (40313530)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  荒木 栄一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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