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USHIO Yukitaka  生塩 之敬

ORCIDConnect your ORCID iD *help
… Alternative Names

生塩 之敬  ウシオ ユキタカ

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Researcher Number 20028583
External Links
Affiliation (based on the past Project Information) *help 1988 – 2002: 熊本大学, 医学部, 教授
1986: 阪大, 医学部, 助手
Review Section/Research Field
Principal Investigator
Cerebral neurosurgery / Biological Sciences
Except Principal Investigator
Cerebral neurosurgery
Keywords
Principal Investigator
グリオーマ / MCP-1 / 脳腫瘍 / malignant glioma / 増殖因子 / PDGF / Glioma / ケモカイン / classification / prognosis … More / EGFR / p16 / p53 / gene analysis / 抗癌剤 / chemotherapy / drug delivery / gene therapy / MCP-1 receptor / monocyte / NF2 / NF1 / Chemotherapy / Growth Factor / dissemination / therapy / growth factor / glioma / 生体内電気穿孔法 / サイトカイン / IL-12 / 電気遺伝子療法 / 遺伝子治療 / chemokine / Drug-resistant / インターフェロン / 制癌剤 / 薬剤耐性 / 癌化学療法 / Adoptive immunotherapy / Lymphokine-activated Killer (LAK) cells / Brain neoplasms / モデル / ガンマ・インターフェロン / インターロイキン-2 / Lymphokine-activated killer(LAK)細胞 / インターロイキシー2 / 養子免疫療法 / LAK細胞 / LOH 10 / 機能的解析 / 生存日数 / PTEN / LOH / 10番染色体 / glioblastoma / LOH10 / GST-fusion protein / anti-cancer drug / microsphere / Invasin / GST融合蛋白 / マイクロスフィアー / invasin / 遺伝子療法 / 免疫 / MCP-1レセプター / マクロファージ / プロモーター / 転写因子 / リンパ球 / 単球 / CCR2 / plasmid DNA / lac Z gene / brain tumor / in vivo electroporation / electro-genetherapy (EGT) / hMCP1 / MCP-1遺伝子 / human MCP-1遺伝子 / lacZ遺伝子 / プラスミドDNA / SURAMIN / TRAPIGIL / GLIOMA / 細胞内情報伝達 / 遺伝子 / Neurofibromatosis / グリオーマ細胞 / スラミン / トラピジ-ル / Fluocytometry / Dissemination / Trapidil / 臨床応用 / DT-A / Hsv-tk / 電気穿孔法 / TAT-GFP / C6グリオーマ細胞 / 悪性脳腫瘍 / 髄腔内播種 / TAT-p16 / TAT-lacZ / TATペプチド融合蛋白 / 自殺遺伝子 / combination electro-gene therapy / HS-tk / ライブラリースクリーニング / EST / 接着分子 / 浸潤 / クローニング / フラクタルカイン / medulloblastoma / ganglioglioma / neurocytoma / cloning / fractalkine … More
Except Principal Investigator
Striatum / MCP-1 / promoter / グリオーマ / substantia nigra / basal ganglia / 悪性脳腫瘍 / 自殺遺伝子 / IL-12 / Basal ganglia / transplantation / Akt / CREB / PHOSPHORYLATION / HIPPOCAMPUS / 燐酸化反応 / リン酸化反応 / 海馬 / development / Cajal-Retzius cells / dopaminergic neurons / cerebral cortex / reeler / Reelin / malignant glioma / methylation / luciferase / cloning / gene / NF2 / suicide gene / electro-gene therapy / monkey / Therapy / Monkey / Movement disorders / Parkinson's disease / Globus pallidus / 脳虚血 / STEP / GABA / N-methyl-D-aspartate / Cerebral ischemia / ケモカイン / glioma / gene regulation / EBP / C / Oct-1 / CCR2 / monocyte / 黒質 / 線条体 / 髄腔内播種 / 悪性グリオーマ / 電気遺伝子療法 / 遺伝子治療 / 免疫組織化学 / Transplantation / プロモーター / マクロファージ / plasticity / cerebral ischemia / neuronal death / ISCHEMIC TOLERANCE / CRE-decoy / 脳虚血耐性 / NEURONAL CELL DEATH / TAR FACTOR / ISCHEMIA / 一過性脳虚血 / タウ因子 / 脳形成 / 軸索形成 / 細胞遊走 / reeler mutant / ドーパミン / clinical application / brain tumor / 安全性 / 脳腫瘍モデル / 臨床応用 / 脳腫瘍 / 電気穿孔法 / subarachnoid dissemination / radio-chemosensitivity / apoptosis / 放射線化学療法感受性 / アポトーシス / CT26 tumor / chemokine gene / gene therapy / Deep brain Stimulation / Movement Disorders / Basal Ganglia / Deep brain stimulation / Tyrosine-phosphatase / Calcium signal / カルシウム / 細胞内情報伝達 / 神経細胞死 / Neuronal development / Tyrosine dephosphorylation / Second messenger / GABA agonist / NMDA receptor / Phoaphatase / STFP / Ca^<2+>-signal / 受容体 / 単球 / TRANSPLANTATION / IMMUNOHISTOCHEMISTRY / MICROGLIA / APOMORPHINE / MAGNETIC RESONANCE IMAGING / SUBSTANTIA NIGRA / STRIATUM / TRANSIENT CEREBRAL ISCHEMIA / カルシニューリン / アポモルフィン / 脳血管透過性 / 一過性虚所脳虚血 / カルシウム結合蛋白 / 再生 / 移植 / ミクログリア / 燐酸化チロシン / カルレチニン / 神経移植 / 血管透過性 / 脳浮腫 / MRI / 選択的神経細胞死 / 一過性局所脳虚血 / LIPOSOME / NITROSOUREAS / INTRATHECAL CHEMOTHERAPY / SUBARACHNOID DISSEMINATION / MALIGNANT GLIOMAS / ACNU / 髄腔内潅流化学療法 / 神経膠腫(グリオーマ) / 髄液腔内潅流療法 / リポソーム / BCNU / リボソーム / ニトロソウレア / 髄腔内化学療法 / 生体内電気穿孔法 / サイトカイン / combination electro-gene therapy / HS-tk / 血管平滑筋 / コラゲン / in situ hybridization / 脳動脈瘤 / マイクロキャリーア / 粒子塞栓物質 / 塞栓術 / Plasticity / Cerebral Ischemia / 発現調節機構 / MCP-1受容体 / substntia nigra / striatum Less
  • Research Projects

    (31 results)
  • Co-Researchers

    (20 People)
  •  生体内電気穿孔法を用いた電気遺伝子療法の臨床応用へ向けた安全性に関する研究Principal Investigator

    • Principal Investigator
      生塩 之敬
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kumamoto University
  •  Research for clinical application of electro-gene therapy against malignant brain tumor

    • Principal Investigator
      KOCHI Masato
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Reformation of the dopaminergic nigrostriatal pathway: a role of reeler gene product Reelin

    • Principal Investigator
      GOTO Satoshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  The role of phosphorylation reaction of tau factor in ischemic neuronal cell death

    • Principal Investigator
      MORIOKA Motohiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Research for the mechanism of ischemic tolerance in neuronal cells

    • Principal Investigator
      YANO Shigetoshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  固形癌に対する自殺遺伝子とサイトカイン遺伝子群を併用した複合電気遺伝子療法の開発Principal Investigator

    • Principal Investigator
      生塩 之敬
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kumamoto University
  •  悪性脳腫瘍の自殺遺伝子・複数サイトカイン遺伝子を用いた複合電気遺伝子療法の開発

    • Principal Investigator
      西 徹
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  シッピシグ・タグ付加レコンビナント蛋白質の髄液内投与と悪性脳腫瘍治療への応用Principal Investigator

    • Principal Investigator
      生塩 之敬
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Research for pathophysiology of subarachnoid dissemination of malignant brain tumors

    • Principal Investigator
      KOCHI Masato
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  CLASSIFICATION OF MALIGNANT GLIOMAS BY MOLECULAR GENETIC ANALYSIS TO DEVELOP RATIONAL THERAPYPrincipal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Role of NF2 tumor suppressor gene promoter in the tumorigenesis

    • Principal Investigator
      TAKESHIMA Hideo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kagoshima University
      Kumamoto University
  •  脳腫瘍における模型ケモカインのクローニングと解析Principal Investigator

    • Principal Investigator
      生塩 之敬
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Development of globus pallidus externus stimulation for Parkinson's disease

    • Principal Investigator
      GOTO Satoshi
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Development of a method for combination electro-gene therapy using suicide gene and chemokine gene(s)

    • Principal Investigator
      NISHI Toru
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Developement of a method for cancer treatment using invsin-conjugated microspherePrincipal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Development of the Gene-missile therapy against human malignant gliomas using monocyte as a carrier.

    • Principal Investigator
      TAKESHIMA Hideo
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Study on the ischemia-induced neuronal injuries with special reference to alterations in the intracellular signaling cascades.

    • Principal Investigator
      GOTO Satoshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  単球遊走因子受容体の発現調節機構の解明と脳腫瘍治療への応用

    • Principal Investigator
      TAKESHIMA Hideo
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  線条体障害ラットにおける大脳基底核神経回路網の再構築移植治療に関する実験的研究

    • Principal Investigator
      後藤 恵
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  新しい粒子塞栓物質の基礎的研究と臨床応用

    • Principal Investigator
      HAMADA Junichiro
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  脳動脈瘤の増大、破裂機序:細胞外マトリックスの変動に関する研究

    • Principal Investigator
      永廣 信治
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  New approach for the treatment of glioblastomas.Principal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  線条体内神経細胞移殖による大脳基底核神経回路網の再構築:虚血性線条体障害ラットを用いた実験的研究

    • Principal Investigator
      後藤 恵
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  DEVELOPMENT OF GENE TRANSFER METHOD FOR SOLID TUMORS USING IN VIVO ELECTROPORATION.Principal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  虚血性大脳基底核障害:動物モデルを用いた病態解折、移植治療に関する実験的研究

    • Principal Investigator
      GOTO Satoshi
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Establishment of the New Approach to the Treatment of Malignant GliomaPrincipal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  INTRATHECAL CHEMOTHERAPY AGAINST SUBARACHNOID DISSEMINATION OF MALIGNANT BRAIN TUMORS

    • Principal Investigator
      HAMADA Junichiro, 河内 正人
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  PATHOPHYSIOLOGY AND TREATMENT OF STRIATONIGRAL ISCHEMIC INJURY

    • Principal Investigator
      NAGAHIRO Shinjl
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY MEDICAL SCHOOL
  •  A Study for New Approaches in the Treatment of Malignant Gliomas.Principal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Molecular Cell Biology of Drug-resistant Glioma and Treatment.Principal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Cooperative effects between chemotherapy and adoptive immunotherapy for brain tumorsPrincipal Investigator

    • Principal Investigator
      YOSHIMINE Toshiki, 生塩 之敬
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Osaka University
  • 1.  NISHI Tohru (00264309)
    # of Collaborated Projects: 17 results
    # of Collaborated Products: 0 results
  • 2.  KOCHI Masato (70178218)
    # of Collaborated Projects: 17 results
    # of Collaborated Products: 0 results
  • 3.  GOTO Satoshi (50240916)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 4.  NAGAHIRO Shinji (60145315)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 5.  KURATSU Jun-ichi (20145296)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 6.  TAKESHIMA Hideo (70244134)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 7.  HAMADA Junichiro (40253752)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 8.  SAYA Hideyuki (80264282)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  MORIOKA Motohiro (20295140)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  SETO Hiroshi (60209848)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  TAKADA Akira (10187966)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  UEMURA Shozaburo (00128258)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  YANO Shigetoshi (60332871)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  NAKANO Masahiro (40002125)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SAITO Yoshiki (50304994)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  YOSHIMINE Toshiki (00201046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  SHIMIZU Keiji (50162699)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  三浦 正毅 (00192352)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  SUGIMOTO Yoshikazu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  SAKATA Tsuneaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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