ohrui hiroshi 大類洋

… Alternative Names

OHRUI Hiroshi 大類洋

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Researcher Number	20100050
External Links
Affiliation (Current)	2023: 横浜薬科大学, 薬学部, 名誉教授
Affiliation (based on the past Project Information) *help	2006: Yokohama College of Pharmacy, School of Pharmacy, Professor, 薬学部, 教授 2005: 東北大学, 名誉教授 2001 – 2004: Graduate School of Life Sciences, Tohoku University, Professor, 大学院・生命科学研究科, 教授 1999 – 2000: 東北大学, 大学院・農学研究科, 教授 1997 – 1998: Tohoku University, Faculty of Agriculture, Professor, 農学部, 教授 … More 1997: Tohoku University, Agricalture, prof., 医学部, 教授 1986 – 1996: 東北大学, 農学部, 助教授 1986: 東北大, 農学部, 助教授 Less
Review Section/Research Field	Principal Investigator Bioproduction chemistry/Bioorganic chemistry / 製造化学・食品 / Bioproduction chemistry/Bioorganic chemistry / Science and Engineering / 応用生物化学・栄養化学 Except Principal Investigator 製造化学・食品 / 応用生物化学・栄養化学 / Radiation science / Bioproduction chemistry/Bioorganic chemistry / Bioproduction chemistry/Bioorganic chemistry / 食品科学・栄養科学 / General surgery
Keywords	Principal Investigator 遠隔位不斉識別 / 蛍光分析 / キラル識別 / 4'-C-置換-2'-デオキシヌクレオシド / chiral discrimination / 蛍光性不斉誘導化試薬 / on-line HPLC-exciton CD analysis / HPLC / キラル分析 / AP-OTf … More / AE-OTf / オカダ酸 / column switching / 9-bromomethylacridine / 分岐脂肪酸 / nucleoside / bioactivity / Organic synthesis / AIDS / virus / nucleic acid / 4'-エチニ-2'-デオキシ-2-フルオロアデノシン / DNAポリメラーゼγ / 血漿半減期 / 薬剤耐性HIV / ヌクレオシド系逆転写酵素阻害薬 / ヌクレオシド / 生理活性 / 合成化学 / エイズ / ウイルス / 核酸 / nucleoside with unprecedentedly highly potent activity and no mouse toxicity / 4'-C-ethynyl-2'-deoxy-2-fluoroadenosine / 4'-C-substituted-2'-deoxynucleoside / physiologic 2'-deoxynucleoside / 2',3'-dideoxy nucleoside / resistant HIV / reverse-transcriptase-inhibitory nucleoside / AIDS chemotherapy / アデノシンデアミナーゼ / 3',4'-置換ヌクレオシド / 4'-置換ヌクレオシド / カルボサイクリクヌクレオシド / 多剤耐性HIV / 4'-置換-2'-デオキシヌクレオシド / 抗HIV活性 / エイズの化学療法 / これまでの最高の抗HIV活性を有し且つマウス毒性ゼロのヌクレオシド / 過去最高の抗HIV活性を有し且つマウス毒性ゼロのヌクレオシド / 4'-C-エチニル-2'-デオキシヌクレオシド / 生理的2'-デオキシヌクレオシド / 2',3'-ジデオキシヌクレオシド / 耐性HIV / 逆転写酵素阻害ヌクレオシド / エイズ化学療法 / methy-branched alcohol / methiy-branched carbosylic acid / methylation analysis of oligosaccharides / determination of absolute configuration / 蛍光性糖骨格誘導化試薬 / フェムトモルレベル分析 / 蛍光CD / 絶対配置の決定 / オンラインHPLC-励起子CD分析 / ^1H-NMR / fluorescent chiral derivatization reagent / branched alcohol / branched fatty acid / discrimination of remote chirality / ゴーシュ効果 / CH-π相互作用 / (S)-1A2P-OTf / (S)-2AP-OTf / 高感度蛍光検出 / OH基用蛍光性不斉誘導化試薬 / メチル分岐キラルカルボン酸 / 蛍光キラル誘導体化試薬 / 分岐アルコール / sequential analysis / D,L-analysis / (S) -TBMB-carboxylic acid / (S) -MNB-carboxylic acid / ベンゾジオキソ-ルカルボン酸 / エナンチオマー / アミノ酸 / オンライン-HPLC-励起子CD分析 / 超微量アミノ酸分析 / アミノ酸のD,L分析 / (S)-TBMB-カルボン酸 / (S)-MNB-カルボン酸 / Determination of beraprost sodium / Determination of prostagrandins / Diarrhetic shellfish toxins / Chiral analysis / Highly sensitive analytical reagents for carboxylic acid / カラムスイッチング / DTX-III / DTX-I / AEOTf / 2、3-(4、5-メチレンジオキシアントラセン)ジカルボキシミドエタノール(MDAEOH) / レーザー励起蛍光標識試薬 / (R)-(2,3-アントラセンカルボキシミド)イソプロピルエチルトリフレート[(R)-AIE-OTf] / ジノフィシストキシン / ベラプロスト・ナトリウムの定量 / プロスタグランジンの定量 / 下痢性貝毒 / 超高感度カルボン酸分析試薬 / hydroperoxy fatty acid / hydroxy fatty acid / mass spectrometry / structural analysis / fatty acid / 9-acridinylmethyl ester / HPLCの新分離条件 / プロスタグランジン / 脂肪酸の定量 / 9ーブロムメチルアクリジン / 高速液体クロマトグラフィ- / 脂肪酸 / 9-ブロモメチルアクリジン / hydroperoxy fatty acld / hydroxy fatty acld / ヒドロペルオキシド / 螢光分析 / フエニル-ジ-β-(6-メトキシナフチル)ホスフィン / フエニル-ジ-β-ナフチルホスフィン / ホスフィン試薬の分子設計 / 立体化学と芳香性 / 光学活性体(〜100%)の合成 / マルメロラクトン / 低温HPLC / 蛍光不斉誘導体化試薬 / 不斉アルキル分岐 / アジド基の光化学分解 / X-線結晶解析 / アジリジノアデニンイソヌクレオシド / ビシナルアジドトシレート / 糖部修飾ヌクレオシド / アジリジノアデノシン / キラル合成 / 構造決定 / GGPL-III / GGPL-I / マイコプラズマフェルメンタンス / 環状スルホン酸エステルのエカトリアル攻撃 / C-グリコシル化反応 / 2-デオキシオクチュロン酸 / シアール酸アナログ / アジド糖の新反応 / 生物活性発見機構 / 抗白血病ヌクレオシド / 抗HIV活性ヌクレオシド / 糖修飾ヌクレオシド / シガトキシンの絶対配座決定 / 分子内環境による6員環形成 / グルコースのβ-C-アリル化 / 糖を原料としたキラル合成 / ABC環モデルのキラル合成 / シガトキシンの免疫抗体 / 立体配座解析と生物活性 / 4'-C-メチルヌクレオシド / 抗エイズ活性 / 抗ウイルスヌクレオシド / 新概念に基づく分子設計 / 糖よりのキラル合成 / 絶対構造式 / ベンガミドE / ピラノ-ス核酸 / 糖修飾核酸 / 4C'ーメチル核酸 / TRNOE法 / 酵素の選択性 / キラル重水素化基質 / 活性中心の立体化学 / ガラクト-スオキシダ-ゼ / 1.6-アンヒドロ糖 / N-結合型糖蛋白質糖鎖 / 位置選択的脱ベンジル化 … More Except Principal Investigator 高速液体クロマトグラフィー / 蛍光分析 / fluorometry / diphenyl pyrenyl phosphine / HPLC / hydroperoxide / N-(9-アクリニジル)マレイミド / 亜硫酸 / シア-ル酸 / dertermination / 蛍光分析システム / ヒドロペルオキシド / ジフェニルー1ーピレニルホスフィン / triacyl glycerol / high performance liquid chromatography / diphenylー1-pyrenylphosphine / determination / GALACTOSE / HEXOSE METABOLISM / LIVER IMAGING / POSITRON TOMOGRAPHY / 糖代謝 / 肝疾患 / 画像診断 / 核医学 / ポジトロン断層撮影 / fat / Carboxylic acid / fruorometry / 9-Bromomethylacridine / thiol / N-(9-Acridinyl)maleinide / 螢光分析 / リポ酸 / メチオニン-γ-リアーゼ / ゼレノシスチン / セレノシステイン / セレノール / 脂肪 / カルボン酸 / 9-ブロモメチルアクリジン / チオール / N-(9-アクリジニル)マレイミド / Stereochemistry / Nuclear magnetic resonance / Insect pheromones / Fluorescence derivatization / High performance liquid chromatography / Enantiomeric discrimination / Chiral amines / Chiral alcohols / 分岐アルコール / 蛍光誘導体化試薬 / キラル誘導体化試薬 / 分岐アルキル / 光学活性化合物 / 蛍光誘導体化法 / 立体化学 / 核磁気共鳴スペクトル / 昆虫フェロモン / 蛍光誘導体化 / 不斉識別 / 光学活性アミン / 光学活性アルコール / chiral discrimination on HPLC / chiral discrimination of methylbranched fatty acides / chiral fluorescent derivatization reagent / ateiso fatty acide / determination of the absolute configuration / キラル分離、 / 絶対配置の決定、 / 分岐脂肪酸、 / キラル分離 / 蛍光不斉誘導体化 / 絶対配置の決定 / 分岐脂肪酸 / HPLCによる不斉識別 / メチル分岐鎖脂肪酸の不斉識別 / 蛍光性不斉誘導化試薬 / アンテイソ脂肪酸 / 絶対配置決定 / High-perfomance liquid chromatography / fluorescence determination / phosphine / lipid hydroperoxide / ジフェニル・1・ピレニルホスフィン / セミミクロ液体クロマトグラフィー / 過酸化脂質の一斉分析 / ジフェニル-1-ピレニルホスフィン / 過酸化脂質の分析 / 高速液体クロマトグラフィ / ホスフィン試薬 / 過酸化脂質 / alpha Gal / xenotransplantation / natural antibody / αガラクトース / 異種移植 / 自然抗体 / Feeding stimulants of leaf beetles / Solution conformation / Sialic acid / Ichthyotoxic substances / Bloom-forming microalgae / Thiolactomycin / Lipids of outer membrane of gram-negative bacteria / Pheromonal lipids of ruminants / オオニジュウヤホシテントウ / 水溶液中の糖の立体配座解析 / 高分解能NMR / 魚毒性溶血性脂質 / 脂肪酸合成阻害 / 皮脂腺 / 特異臭脂肪酸 / KDO / 魚毒性・溶血性脂質 / 特異的脂肪酸 / 摂食刺激物質 / ハムシ / 赤潮プランクトン / キラル重水素化糖ーNMR法 / 細菌表層脂質 / チオラクトマイシン / コミュニケ-ション脂質 / 反すう動物 / 選択的脱ベンジル化反応 / 立体配座解析 / N-結合型オリゴ糖 / キラル重水素標識化糖 / 硫化水素 / 雨水 / preーcolumn method / phosphine oxide / labeling reagent / exo-アノマ-効果 / 2-6結合の立体配座 / アノマ-配置の決定法 Less

Development of innovative anti-HIV drugs effective for all types of AIDS virusesPrincipal Investigator
- Principal Investigator
  
  OHRUI Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Yokohama College of Pharmacy
  Tohoku University
Highly sensitive enantiomeric discrimination of chiral branched alkyl chains of fatty alcohols and amines, and the application to determine absolute stereochemistry of natural occurring products
- Principal Investigator
  
  AKASAKA Kazuaki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tohoku University
Development of 4'-C-ethynyl-2'-deoxy-2F-adenosine that is highly active against a multi-drug resistant HIVPrincipal Investigator
- Principal Investigator
  
  OHRUI Hiroshi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tohoku University
不斉アルキル分岐を有する天然化合物の超高感度絶対配置決定法の開発Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University
Development of highly sensitive system for determination of absolute configuration of natural-products by labelling with chiral fluorescent reagentsPrincipal Investigator
- Principal Investigator
  
  OHRUI Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  TOHOKU UNIVERSITY
Development of general chiral method for chiral branched-chain carboxylic acids
- Principal Investigator
  
  AKASAKA Kazuaki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  TOHOKU UNIVERSITY
Development of chiral fluorescent derivatization reagents for discrimination of enantiomers having chiral centers far remote from the derizatizable functional groups and their application to determination of absolute configuration of natural productsPrincipal Investigator
- Principal Investigator
  
  OHRUI Hiroshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  TOHOKU UNIVERSITY
Development of automatic semi-micro simultaneus determination system for lipid hydroperoxides in human plasma
- Principal Investigator
  
  AKASAKA Kazuaki
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  食品科学・栄養科学
- Research Institution
  TOHOKU UNIVERSITY
ビシナル・アジド・トシレートと核酸塩基によるアジリジノヌクレオシド生成反応の研究Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tohoku University
Development of a new highly sensitive D,L-discriminating amino acid analyzerPrincipal Investigator
- Principal Investigator
  
  OHRUI Hiroshi, 目黒煕
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tohoku University
The prolongation of xenograft survival with human natural xenoantibody elimination
- Principal Investigator
  
  SATO Akira, 佐竹正博
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Tohoku University
ATLとAIDSウィルスに同時感染T細胞から単離されたグリセロ糖燐脂質の合成研究Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tohoku University
Development of highly sensitive analytical system for biologically active hydroxylated fatty acids with a new fluorescent derivatization reagent, AE-OTfPrincipal Investigator
- Principal Investigator
  
  OHRUI Hiroshi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tohoku University
核酸の構造と機能研究のための新しい糖骨格をもつヌクレオシドの合成Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
シアール酸・KDOの誘導体とそれらを含有する糖鎖の合成とNMRによる立体配座解析Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
糖を用いるキラル合成によるシガトキシンの絶対構造式の決定及びその免疫抗体作成研究Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  製造化学・食品
- Research Institution
  Tohoku University
核酸の構造と機能研究のための新しい糖骨格を持つヌクレオシドの合成研究Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
糖を用いるキラル合成による海綿由来の抗寄生虫アミノ酸ベンガミドの絶対構造式の決定Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  製造化学・食品
- Research Institution
  Tohoku University
核酸の構造と機能研究のための新しい糖骨格をもつタクレオシドの合成Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
キラル重水素標識化糖を用いたDーガラクト-スオキシダ-ゼの活性中心の立体化学研究Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用生物化学・栄養化学
- Research Institution
  Tohoku University
蛍光発色団を有するホスフィンオキシド類の合成と超高感度分析への応用に関する研究
- Principal Investigator
  
  目黒煕
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  製造化学・食品
- Research Institution
  Tohoku University
オリゴ糖糖鎖シアル酸結合部位の立体配置並びに立体配座解析法の開発
- Principal Investigator
  
  MEGURO Hiroshi
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用生物化学・栄養化学
- Research Institution
  Tohoku University
新しい位置選択的脱O-ベンジル化反応の糖鎖合成への応用Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  製造化学・食品
- Research Institution
  Tohoku University
Studies on the Allelopathic or Pheromonal Lipids on the Body-Surface of Organisms.
- Principal Investigator
  
  YAMASHITA Kyohei
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  製造化学・食品
- Research Institution
  Tohoku University
System for fluorometry of carboxylic acids under mild conditionPrincipal Investigator
- Principal Investigator
  
  OHRUI Hiroshi
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  製造化学・食品
- Research Institution
  TOHOKU UNIVERSITY
糖蛋白質糖鎖の立体配座に関する研究
- Principal Investigator
  
  目黒煕
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用生物化学・栄養化学
- Research Institution
  Tohoku University
ホスフィンの特性を生かした螢光試薬の分子設計に関する研究Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  製造化学・食品
- Research Institution
  Tohoku University
Development of Micro Analytical System of Hydroperoxides in Lipids
- Principal Investigator
  
  MEGURO Hiroshi
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  応用生物化学・栄養化学
- Research Institution
  Tohoku University
光学純度100%果実芳香成分マルメロラクトン,オキシド類の合成とその生理活性Principal Investigator
- Principal Investigator
  
  大類洋
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  製造化学・食品
- Research Institution
  Tohoku University
QUANTITATIVE REGIONAL MAPPING OF LIVER FUNCTION USING FLUORINATED POSITRON EMITTERS AND POSITRON EMISSION TOMOGRAPHY
- Principal Investigator
  
  ITOH MASATOSHI
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  TOHOKU UNIVERSITY
Development of new ultra micro analytical system based on the acridine fluorometry
- Principal Investigator
  
  MEGURO Hiroshi
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  製造化学・食品
- Research Institution
  TOHOKU UNIVERSITY
環境試料中のSH,SS化合物及びSO⊆の簡易迅速分析法の開発に関する研究
- Principal Investigator
  
  目黒煕
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for Environmental Science
- Research Institution
  Tohoku University

All 2007 2006 2005 2004

All Journal Article Book Patent

[Book] 耐性HIVが発現しない抗HIVヌクレオシド創製への挑戦2005
- Author(s)
  大類洋
- Total Pages
  21
- Publisher
  笹木出版印刷株式会社
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] Selectivity Enhancement for trans-2-(2,3- Anthracendicarboximido)cyclohexane Derived Diastereomers in HPLC by using an Ordered Organic Stationary phase2007
- Author(s)
  Atsushi Shundo, Megumi Fukui, Makoto Takafuji, Kazuaki Akasaka, Hiroshi Ohrui, Dusan Berek, Hirotaka Ihara
- Journal Title
  
  Analytical Sciences 23
  
  Pages: 311-315
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380076
[Journal Article] 耐性HIVを発現させない低毒性逆転写酵素阻害ヌクレオシドの創製成研究2006
- Author(s)
  大類洋
- Journal Title
  
  有機合成化学協会誌 64-7
  
  Pages: 716-723
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine : A nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma2006
- Author(s)
  Hiroshi Ohrui
- Journal Title
  
  Nucleic Acids Symposium Series -50
  
  Pages: 1-2
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine : A nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma2006
- Author(s)
  Hiroshi Ohrui
- Journal Title
  
  Nucleic Acids Symposium Series 50
  
  Pages: 1-2
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] Chiral Discrimination of Primary Amins by HPLC After Labeling with a Chiral Derivatization Reagent, trans-2-(2,3-Anthracenedicarbox-imido)cyclohexanecarbonyl Chloride2006
- Author(s)
  Kazuaki Akasaka, Takashi Ohtaki, Hiroshi Ohrui
- Journal Title
  
  Journal of Separation Science 29
  
  Pages: 1390-1398
- Data Source
  KAKENHI-PROJECT-16380076
[Journal Article] Chiral Discrimination of Primary Amins by HPLC After Labeling with a Chiral Derivatization Reagent, trans-2-(2,3-Anthracenedicarboximido)cyclohexanecarbonyl Chloride2006
- Author(s)
  Kazuaki Akasaka, Takashi Ohtaki, Hiroshi Ohrui
- Journal Title
  
  J.Separation Science 29(10)
  
  Pages: 1390-1398
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380076
[Journal Article] 耐性HIVを発現させない・高活性・低毒性・逆転写酵素阻害ヌクレオシドの創製研究2006
- Author(s)
  大類洋
- Journal Title
  
  実用産業情報 46
  
  Pages: 2-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] 2'-Deoxy-4'-C-Ethynyl-2-Fluoroadenosine, a Nucleoside Reverse Transcriptase Inhibitor, Is Highly Potent Against All Human Immunodeficiency Viruses Type a and Has Low Toxicity2006
- Author(s)
  Hiroshi Ohrui
- Journal Title
  
  The Chemical Record 6・3
  
  Pages: 133-143
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] Creation of low toxic reverse-transcriptase inhibitory nucleosides that prevent the emergence of drug-resistant HIV variants2006
- Author(s)
  Hiroshi Ohrui, Hiroyuki Hayakawa, Satoru Kohgo, Masao Matsuoka, Eiichi Kodama, Hiroaki Mitusya
- Journal Title
  
  Yuki Gosei Kagaku Kyoukaishi 64
  
  Pages: 716-723
- NAID
  10017617749
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] 耐性HIVを発現させない低毒性逆転写酵素阻害ヌクレオシドの創製研究2006
- Author(s)
  大類洋
- Journal Title
  
  有機合成化学協会誌 64・7
  
  Pages: 716-723
- NAID
  10017617749
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] Chiral Discrimination of Primary Amins by HPLC After Labeling with a Chiral Derivatization Reagent, trans-2-(2,3-Anthracenedicarbox- imido)cyclohexanecarbonyl Chloride2006
- Author(s)
  Kazuaki Akasaka, Takashi Ohtaki, Hiroshi Ohrui
- Journal Title
  
  Journal of Separation Science 29
  
  Pages: 1390-1398
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16380076
[Journal Article] 耐性HIVを発現させない,低毒性・高活性の逆転写酵素阻害ヌクレオシドの創製2006
- Author(s)
  大類洋
- Journal Title
  
  化学と生物 44・10
  
  Pages: 660-662
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] Creation of low toxic and highly active reverse-transcriptase-inhibiting nucleosides which avoid the emergence of resistant HIV. Can they be dream drugs for AIDS or hepatitis B.2006
- Author(s)
  Hiroshi Ohrui
- Journal Title
  
  Kagaku to Seibutsu 44
  
  Pages: 660-662
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] Creation of low toxic and highly active reverse-transcriptase-inhibiting nucleosides which avoid the emergence of resistant HIV.2006
- Author(s)
  Hiroshi Ohrui
- Journal Title
  
  Jitsuyo Sangyo Jyoho 46
  
  Pages: 2-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine : a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma.2006
- Author(s)
  Hiroshi Ohrui, Satoru Kohgo, Hiroyuki Hayakawa, Eiichi Kodama, Masao Matsuoka, Tomohiro Nakata, Hiroyuki Mitsuya
- Journal Title
  
  Nucleic acids symposium series 50
  
  Pages: 1-2
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] 2'-Deoxy-4'-C-Ethynyl-2-Fluoroadenosine, a Nucleoside Reverse Transcriptase Inhibitor, Is Highly Potent Against All Human Immunodeficiency Viruses Type a and Has Low Toxicity2006
- Author(s)
  Hiroshi Ohrui
- Journal Title
  
  The Chemical Record 6-3
  
  Pages: 133-143
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] Direct determination of the stereoisomers constitution by 2D-HPLC and stereochemistry-pheromone acitivity relationship of the copulation release pheromone of the cowpea weevil, Callosobruchus maculates2006
- Author(s)
  Arata Yajima, Kazuaki Akasaka, Tomonori Bakai, Hiroki Maehara, Tomoo Nukada, Hiroshi Ohrui, Goro Yabuta
- Journal Title
  
  Tetrahedron 62
  
  Pages: 4590-4596
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380076
[Journal Article] 耐性HIVを発現させない,低毒性・高活性の逆転写酵素阻害ヌクレオシドの創製2006
- Author(s)
  大類洋
- Journal Title
  
  化学と生物 44-10
  
  Pages: 660-662
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] 耐性HIVを発現させない・高活性・低毒性・逆転写酵素阻害ヌクレオシドの創製研究2006
- Author(s)
  大類洋
- Journal Title
  
  実用産業情報 -39
  
  Pages: 2-10
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity.2006
- Author(s)
  Hiroshi Ohrui
- Journal Title
  
  Chemical Record 6
  
  Pages: 133-143
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380070
[Journal Article] Development of Highly Potent D-Glucosamine-Based Chiral Fluorescent Labeling Reagents and a Microwave-Assisted beta-Selective Glycosidation of a Methyl Glycoside Reagent2005
- Author(s)
  Hiroshi Ohrui, Kazuaki Akasaka, 他4名
- Journal Title
  
  Bioscience, Biotechnology and Boichemistry 69・5
  
  Pages: 1054-1057
- Data Source
  KAKENHI-PROJECT-16380076
[Journal Article] Synthesis of four stereoisomers of 2,6-dimethyloctane-1,8-dioic acid, a component of the copulation release pheromone of the cowpea weevil, Callosobruchus maculates2005
- Author(s)
  Tomonori Nakai, Arata Yajima, Kazuaki Akasaka, Takayuki Kaihoku, Miki Ohtaki, Tomoo Nukada, Hiroshi Ohrui, Goro Yabuta
- Journal Title
  
  Bioscience, Biotechnology and Boichemistry 69(12)
  
  Pages: 2401-2408
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380076
[Journal Article] Development of Highly Potent D-Glucosamine-Based Chiral Fluorescent Labeling Reagents and a Microwave-Assisted β-Selective Glycosidation of a Methyl Glycoside Reagent,2005
- Author(s)
  Hiroshi Ohrui, Rumiko Katoh, Teruhisa Kodaira, Hiroki Shimizu, Kazuaki Akasaka, Takeshi Kitahara
- Journal Title
  
  Bioscience, Biotechnology and Boichemistry 69(5)
  
  Pages: 1054-1057
- NAID
  130000030345
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380076
[Journal Article] Crystalline structure of N-(S)-2-heptyl (1R,2R)-2-(2,3-anthracenedicarboximido)cyclohexanecarboxamide that differs from its preferred conformation in the solvent used for crystallization2005
- Author(s)
  Kazuaki Akasaka, Takashi Ohtaki, Chizuko Kabuto, Takeshi Kitahara, Hiroshi Ohrui
- Journal Title
  
  Bioscience, Biotechnology and Boichemistry 69(10)
  
  Pages: 2002-2004
- NAID
  130000030540
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380076
[Journal Article] Development of Highly Potent D-Glucosamine-Based Chiral Fluorescent Labeling Reagents and a Microwave-Assisted β-Selective Glycosidation of a Methyl Glycoside Reagent2005
- Author(s)
  Hiroshi Ohrui, Kazuaki Akasaka, 他4名
- Journal Title
  
  Bioscience, Biotechnology and Boichemistry 69・5
  
  Pages: 1054-1057
- NAID
  130000030345
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16380076
[Journal Article] Chiral Discrimination of secondary alcohols by both ^1H-NMR and HPLC after labeling with a chiral derivatization reagent, 2-(2,3-anthracenedi-carboximide)cyclohexane carboxylic Acid,2005
- Author(s)
  Takashi Ohtaki, Kazuaki Akasaka, Chizuko Kabuto, Hiroshi Ohrui
- Journal Title
  
  Chirality 17(S1)
  
  Pages: 171-176
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380076
[Journal Article] Design, efficient Synthesis and Anti-HIV Activity of 4'-C-Cyano-and 4'-C-Ethynyl-2'-deoxy Purine Nucleosides2004
- Author(s)
  S.Kohgo, K.Yamada, K.Kitano, Y.Iwai, S.Sakata, N.Ashida, H.Hayakawa, D.Nameki, E.Kodama, H.Mitsuya, H.Ohrui
- Journal Title
  
  NUCLEOSIDES, NUCLEOTIDES&NUCLEIC ACIDS vol23,No4
  
  Pages: 671-690
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14360062
[Journal Article] Design, Efficient Synthesis, and Anti-HIV Activity of 4'-C-Cyano-and 4'-C-Ethynyl-2'-deoxy Purine Nucloesides2004
- Author(s)
  S.Kohgo, K.Yamada, K.Kitano, Y.Iwai, S.Sakata, N.Ashida, H.Hayakawa, D.Nameki, E.Kodama, M.Matsuoka, H.Mitsuya, H.Ohrui
- Journal Title
  
  NUCLEOSIDES, NUCLEOTIDES&NUCLEIC ACIDS 23・4
  
  Pages: 671-690
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14360062
[Journal Article] Design, Efficient Synthesis, and Anti-HIV Activity of 4'-C-Cyano- and 4'-C-Ethynyl-2'-deoxy Purine Nucloesides2004
- Author(s)
  S.Kohgo, K.Yawada, K.Kitano, Y.Iwai, S.Sakata, N.Ashida, H.Hayakawa, D.Nameki, E.Kodama, M.Matsuoka, H.Mitsuya, H.Ohrui
- Journal Title
  
  NUCLEOSIDES, NUCLEOTIDES&NUCLEIC ACIDS 23・4
  
  Pages: 671-690
- Data Source
  KAKENHI-PROJECT-14360062
[Patent] 4'-C-置換-2-ハロアデノシン誘導体2005
- Inventor(s)
  大類洋他
- Industrial Property Rights Holder
  ヤマサ醤油株式会社
- Filing Date
  2005-09-29
- Data Source
  KAKENHI-PROJECT-17380070

1. NISHIDA Yoshihiro (80183896)

# of Collaborated Projects: 13 results

# of Collaborated Products: 0 results
2. AKASAKA Kazuaki (10201881)

# of Collaborated Projects: 13 results

# of Collaborated Products: 11 results
3. MEGURO Hiroshi (30005590)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
4. TAKAHASHI Hiroaki

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 鈴木建夫 (80005652)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SATO Akira (20250764)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YAMASHITA Kyohei (90005570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUDA Kazuhiro (00005662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YASUMOTO Takeshi (20011885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. IZAKI Kazuo (80005587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FUJIMORI Keisei (50238622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. DOI Hideyuki (90188839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KUWAHARA Shigefumi (30170145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ITOH MASATOSHI (00125501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MATSUZAWA TAIJU (10006108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. FUKUDA HIROSHI (30125645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TADA MASAO (10006083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 堀江浩子 (40241559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 佐竹正博 (70147370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 清水弘樹 (30344716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. UMETSU Teruhiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YAMAUCHI Yoshio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. WADA Akio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ohrui hiroshi 大類 洋

OHRUI Hiroshi 大類 洋

Research Projects

Research Products

Co-Researchers

Development of innovative anti-HIV drugs effective for all types of AIDS virusesPrincipal Investigator

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Highly sensitive enantiomeric discrimination of chiral branched alkyl chains of fatty alcohols and amines, and the application to determine absolute stereochemistry of natural occurring products

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Development of 4'-C-ethynyl-2'-deoxy-2F-adenosine that is highly active against a multi-drug resistant HIVPrincipal Investigator

Principal Investigator

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不斉アルキル分岐を有する天然化合物の超高感度絶対配置決定法の開発Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Development of highly sensitive system for determination of absolute configuration of natural-products by labelling with chiral fluorescent reagentsPrincipal Investigator

Principal Investigator

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Research Institution

Development of general chiral method for chiral branched-chain carboxylic acids

Principal Investigator

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Research Institution

Development of chiral fluorescent derivatization reagents for discrimination of enantiomers having chiral centers far remote from the derizatizable functional groups and their application to determination of absolute configuration of natural productsPrincipal Investigator

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Research Institution

Development of automatic semi-micro simultaneus determination system for lipid hydroperoxides in human plasma

Principal Investigator

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Research Institution

ビシナル・アジド・トシレートと核酸塩基によるアジリジノヌクレオシド生成反応の研究Principal Investigator

Principal Investigator

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Development of a new highly sensitive D,L-discriminating amino acid analyzerPrincipal Investigator

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Research Institution

The prolongation of xenograft survival with human natural xenoantibody elimination

Principal Investigator

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ATLとAIDSウィルスに同時感染T細胞から単離されたグリセロ糖燐脂質の合成研究Principal Investigator

Principal Investigator

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Research Institution

Development of highly sensitive analytical system for biologically active hydroxylated fatty acids with a new fluorescent derivatization reagent, AE-OTfPrincipal Investigator

Principal Investigator

Project Period (FY)

ohrui hiroshi 大類洋

OHRUI Hiroshi 大類洋