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ohrui hiroshi  大類 洋

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OHRUI Hiroshi  大類 洋

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Researcher Number 20100050
External Links
Affiliation (Current) 2021: 横浜薬科大学, 薬学部, 名誉教授
Affiliation (based on the past Project Information) *help 2006: Yokohama College of Pharmacy, School of Pharmacy, Professor, 薬学部, 教授
2005: 東北大学, 名誉教授
2001 – 2004: Graduate School of Life Sciences, Tohoku University, Professor, 大学院・生命科学研究科, 教授
1999 – 2000: 東北大学, 大学院・農学研究科, 教授
1997 – 1998: Tohoku University, Faculty of Agriculture, Professor, 農学部, 教授 … More
1997: Tohoku University, Agricalture, prof., 医学部, 教授
1986 – 1996: 東北大学, 農学部, 助教授
1986: 東北大, 農学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Bioproduction chemistry/Bioorganic chemistry / 製造化学・食品 / 応用生物化学・栄養化学 / Science and Engineering / Bioproduction chemistry/Bioorganic chemistry
Except Principal Investigator
応用生物化学・栄養化学 / 製造化学・食品 / General surgery / 食品科学・栄養科学 / Bioproduction chemistry/Bioorganic chemistry / Bioproduction chemistry/Bioorganic chemistry / Radiation science
Keywords
Principal Investigator
キラル識別 / 蛍光分析 / 遠隔位不斉識別 / 分岐脂肪酸 / 9-bromomethylacridine / column switching / オカダ酸 / AE-OTf / AP-OTf / キラル分析 … More / HPLC / on-line HPLC-exciton CD analysis / 蛍光性不斉誘導化試薬 / chiral discrimination / 4'-C-置換-2'-デオキシヌクレオシド / 位置選択的脱ベンジル化 / N-結合型糖蛋白質糖鎖 / 1.6-アンヒドロ糖 / ガラクト-スオキシダ-ゼ / 活性中心の立体化学 / キラル重水素化基質 / 酵素の選択性 / TRNOE法 / 4C'ーメチル核酸 / 糖修飾核酸 / ピラノ-ス核酸 / ベンガミドE / 絶対構造式 / 糖よりのキラル合成 / 新概念に基づく分子設計 / 抗ウイルスヌクレオシド / 抗エイズ活性 / 4'-C-メチルヌクレオシド / 立体配座解析と生物活性 / シガトキシンの免疫抗体 / ABC環モデルのキラル合成 / 糖を原料としたキラル合成 / グルコースのβ-C-アリル化 / 分子内環境による6員環形成 / シガトキシンの絶対配座決定 / 糖修飾ヌクレオシド / 抗HIV活性ヌクレオシド / 抗白血病ヌクレオシド / 生物活性発見機構 / アジド糖の新反応 / シアール酸アナログ / 2-デオキシオクチュロン酸 / C-グリコシル化反応 / 環状スルホン酸エステルのエカトリアル攻撃 / マイコプラズマフェルメンタンス / GGPL-I / GGPL-III / 構造決定 / キラル合成 / アジリジノアデノシン / 糖部修飾ヌクレオシド / ビシナルアジドトシレート / アジリジノアデニンイソヌクレオシド / X-線結晶解析 / アジド基の光化学分解 / 不斉アルキル分岐 / 蛍光不斉誘導体化試薬 / 低温HPLC / マルメロラクトン / 光学活性体(〜100%)の合成 / 立体化学と芳香性 / ホスフィン試薬の分子設計 / フエニル-ジ-β-ナフチルホスフィン / フエニル-ジ-β-(6-メトキシナフチル)ホスフィン / 螢光分析 / ヒドロペルオキシド / hydroxy fatty acld / hydroperoxy fatty acld / 9-ブロモメチルアクリジン / 脂肪酸 / 高速液体クロマトグラフィ- / 9ーブロムメチルアクリジン / 脂肪酸の定量 / プロスタグランジン / HPLCの新分離条件 / 9-acridinylmethyl ester / fatty acid / structural analysis / mass spectrometry / hydroxy fatty acid / hydroperoxy fatty acid / 超高感度カルボン酸分析試薬 / 下痢性貝毒 / プロスタグランジンの定量 / ベラプロスト・ナトリウムの定量 / ジノフィシストキシン / (R)-(2,3-アントラセンカルボキシミド)イソプロピルエチルトリフレート[(R)-AIE-OTf] / レーザー励起蛍光標識試薬 / 2、3-(4、5-メチレンジオキシアントラセン)ジカルボキシミドエタノール(MDAEOH) / AEOTf / DTX-I / DTX-III / カラムスイッチング / Highly sensitive analytical reagents for carboxylic acid / Chiral analysis / Diarrhetic shellfish toxins / Determination of prostagrandins / Determination of beraprost sodium / (S)-MNB-カルボン酸 / (S)-TBMB-カルボン酸 / アミノ酸のD,L分析 / 超微量アミノ酸分析 / オンライン-HPLC-励起子CD分析 / アミノ酸 / エナンチオマー / ベンゾジオキソ-ルカルボン酸 / (S) -MNB-carboxylic acid / (S) -TBMB-carboxylic acid / D,L-analysis / sequential analysis / 分岐アルコール / 蛍光キラル誘導体化試薬 / メチル分岐キラルカルボン酸 / OH基用蛍光性不斉誘導化試薬 / 高感度蛍光検出 / (S)-2AP-OTf / (S)-1A2P-OTf / CH-π相互作用 / ゴーシュ効果 / discrimination of remote chirality / branched fatty acid / branched alcohol / fluorescent chiral derivatization reagent / ^1H-NMR / オンラインHPLC-励起子CD分析 / 絶対配置の決定 / 蛍光CD / フェムトモルレベル分析 / 蛍光性糖骨格誘導化試薬 / determination of absolute configuration / methylation analysis of oligosaccharides / methiy-branched carbosylic acid / methy-branched alcohol / エイズ化学療法 / 逆転写酵素阻害ヌクレオシド / 耐性HIV / 2',3'-ジデオキシヌクレオシド / 生理的2'-デオキシヌクレオシド / 4'-C-エチニル-2'-デオキシヌクレオシド / 過去最高の抗HIV活性を有し且つマウス毒性ゼロのヌクレオシド / これまでの最高の抗HIV活性を有し且つマウス毒性ゼロのヌクレオシド / エイズの化学療法 / 抗HIV活性 / 4'-置換-2'-デオキシヌクレオシド / 多剤耐性HIV / カルボサイクリクヌクレオシド / 4'-置換ヌクレオシド / 3',4'-置換ヌクレオシド / アデノシンデアミナーゼ / AIDS chemotherapy / reverse-transcriptase-inhibitory nucleoside / resistant HIV / 2',3'-dideoxy nucleoside / physiologic 2'-deoxynucleoside / 4'-C-substituted-2'-deoxynucleoside / 4'-C-ethynyl-2'-deoxy-2-fluoroadenosine / nucleoside with unprecedentedly highly potent activity and no mouse toxicity / 核酸 / ウイルス / エイズ / 合成化学 / 生理活性 / ヌクレオシド / ヌクレオシド系逆転写酵素阻害薬 / 薬剤耐性HIV / 血漿半減期 / DNAポリメラーゼγ / 4'-エチニ-2'-デオキシ-2-フルオロアデノシン / nucleic acid / virus / AIDS / Organic synthesis / bioactivity / nucleoside … More
Except Principal Investigator
fluorometry / 蛍光分析 / 高速液体クロマトグラフィー / シア-ル酸 / 亜硫酸 / N-(9-アクリニジル)マレイミド / hydroperoxide / HPLC / diphenyl pyrenyl phosphine / アノマ-配置の決定法 / 2-6結合の立体配座 / exo-アノマ-効果 / labeling reagent / phosphine oxide / preーcolumn method / 雨水 / 硫化水素 / キラル重水素標識化糖 / N-結合型オリゴ糖 / 立体配座解析 / 選択的脱ベンジル化反応 / 反すう動物 / コミュニケ-ション脂質 / チオラクトマイシン / 細菌表層脂質 / キラル重水素化糖ーNMR法 / 赤潮プランクトン / ハムシ / 摂食刺激物質 / 特異的脂肪酸 / 魚毒性・溶血性脂質 / KDO / 特異臭脂肪酸 / 皮脂腺 / 脂肪酸合成阻害 / 魚毒性溶血性脂質 / 高分解能NMR / 水溶液中の糖の立体配座解析 / オオニジュウヤホシテントウ / Pheromonal lipids of ruminants / Lipids of outer membrane of gram-negative bacteria / Thiolactomycin / Bloom-forming microalgae / Ichthyotoxic substances / Sialic acid / Solution conformation / Feeding stimulants of leaf beetles / 自然抗体 / 異種移植 / αガラクトース / natural antibody / xenotransplantation / alpha Gal / 過酸化脂質 / ホスフィン試薬 / 高速液体クロマトグラフィ / 過酸化脂質の分析 / ジフェニル-1-ピレニルホスフィン / 過酸化脂質の一斉分析 / セミミクロ液体クロマトグラフィー / ジフェニル・1・ピレニルホスフィン / lipid hydroperoxide / phosphine / fluorescence determination / High-perfomance liquid chromatography / 絶対配置決定 / アンテイソ脂肪酸 / 蛍光性不斉誘導化試薬 / メチル分岐鎖脂肪酸の不斉識別 / HPLCによる不斉識別 / 分岐脂肪酸 / 絶対配置の決定 / 蛍光不斉誘導体化 / キラル分離 / 分岐脂肪酸、 / 絶対配置の決定、 / キラル分離、 / determination of the absolute configuration / ateiso fatty acide / chiral fluorescent derivatization reagent / chiral discrimination of methylbranched fatty acides / chiral discrimination on HPLC / 光学活性アルコール / 光学活性アミン / 不斉識別 / 蛍光誘導体化 / 昆虫フェロモン / 核磁気共鳴スペクトル / 立体化学 / 蛍光誘導体化法 / 光学活性化合物 / 分岐アルキル / キラル誘導体化試薬 / 蛍光誘導体化試薬 / 分岐アルコール / Chiral alcohols / Chiral amines / Enantiomeric discrimination / High performance liquid chromatography / Fluorescence derivatization / Insect pheromones / Nuclear magnetic resonance / Stereochemistry / N-(9-アクリジニル)マレイミド / チオール / 9-ブロモメチルアクリジン / カルボン酸 / 脂肪 / セレノール / セレノシステイン / ゼレノシスチン / メチオニン-γ-リアーゼ / リポ酸 / 螢光分析 / N-(9-Acridinyl)maleinide / thiol / 9-Bromomethylacridine / fruorometry / Carboxylic acid / fat / ポジトロン断層撮影 / 核医学 / 画像診断 / 肝疾患 / 糖代謝 / POSITRON TOMOGRAPHY / LIVER IMAGING / HEXOSE METABOLISM / GALACTOSE / determination / diphenylー1-pyrenylphosphine / high performance liquid chromatography / triacyl glycerol / ジフェニルー1ーピレニルホスフィン / ヒドロペルオキシド / 蛍光分析システム / dertermination Less
  • Research Projects

    (32 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (23 People)
  •  Development of innovative anti-HIV drugs effective for all types of AIDS virusesPrincipal Investigator

    • Principal Investigator
      OHRUI Hiroshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Yokohama College of Pharmacy
      Tohoku University
  •  Highly sensitive enantiomeric discrimination of chiral branched alkyl chains of fatty alcohols and amines, and the application to determine absolute stereochemistry of natural occurring products

    • Principal Investigator
      AKASAKA Kazuaki
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Tohoku University
  •  Development of 4'-C-ethynyl-2'-deoxy-2F-adenosine that is highly active against a multi-drug resistant HIVPrincipal Investigator

    • Principal Investigator
      OHRUI Hiroshi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Tohoku University
  •  不斉アルキル分岐を有する天然化合物の超高感度絶対配置決定法の開発Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Science and Engineering
    • Research Institution
      Tohoku University
  •  Development of highly sensitive system for determination of absolute configuration of natural-products by labelling with chiral fluorescent reagentsPrincipal Investigator

    • Principal Investigator
      OHRUI Hiroshi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      TOHOKU UNIVERSITY
  •  Development of general chiral method for chiral branched-chain carboxylic acids

    • Principal Investigator
      AKASAKA Kazuaki
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      TOHOKU UNIVERSITY
  •  Development of chiral fluorescent derivatization reagents for discrimination of enantiomers having chiral centers far remote from the derizatizable functional groups and their application to determination of absolute configuration of natural productsPrincipal Investigator

    • Principal Investigator
      OHRUI Hiroshi
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      TOHOKU UNIVERSITY
  •  Development of automatic semi-micro simultaneus determination system for lipid hydroperoxides in human plasma

    • Principal Investigator
      AKASAKA Kazuaki
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      食品科学・栄養科学
    • Research Institution
      TOHOKU UNIVERSITY
  •  ビシナル・アジド・トシレートと核酸塩基によるアジリジノヌクレオシド生成反応の研究Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Tohoku University
  •  Development of a new highly sensitive D,L-discriminating amino acid analyzerPrincipal Investigator

    • Principal Investigator
      OHRUI Hiroshi, 目黒 煕
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Tohoku University
  •  The prolongation of xenograft survival with human natural xenoantibody elimination

    • Principal Investigator
      SATO Akira, 佐竹 正博
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Tohoku University
  •  ATLとAIDSウィルスに同時感染T細胞から単離されたグリセロ糖燐脂質の合成研究Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Tohoku University
  •  Development of highly sensitive analytical system for biologically active hydroxylated fatty acids with a new fluorescent derivatization reagent, AE-OTfPrincipal Investigator

    • Principal Investigator
      OHRUI Hiroshi
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Tohoku University
  •  核酸の構造と機能研究のための新しい糖骨格をもつヌクレオシドの合成Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  シアール酸・KDOの誘導体とそれらを含有する糖鎖の合成とNMRによる立体配座解析Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  糖を用いるキラル合成によるシガトキシンの絶対構造式の決定及びその免疫抗体作成研究Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      製造化学・食品
    • Research Institution
      Tohoku University
  •  核酸の構造と機能研究のための新しい糖骨格を持つヌクレオシドの合成研究Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  糖を用いるキラル合成による海綿由来の抗寄生虫アミノ酸ベンガミドの絶対構造式の決定Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      製造化学・食品
    • Research Institution
      Tohoku University
  •  核酸の構造と機能研究のための新しい糖骨格をもつタクレオシドの合成Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  キラル重水素標識化糖を用いたDーガラクト-スオキシダ-ゼの活性中心の立体化学研究Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用生物化学・栄養化学
    • Research Institution
      Tohoku University
  •  蛍光発色団を有するホスフィンオキシド類の合成と超高感度分析への応用に関する研究

    • Principal Investigator
      目黒 煕
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      製造化学・食品
    • Research Institution
      Tohoku University
  •  オリゴ糖糖鎖シアル酸結合部位の立体配置並びに立体配座解析法の開発

    • Principal Investigator
      MEGURO Hiroshi
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用生物化学・栄養化学
    • Research Institution
      Tohoku University
  •  新しい位置選択的脱O-ベンジル化反応の糖鎖合成への応用Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      製造化学・食品
    • Research Institution
      Tohoku University
  •  Studies on the Allelopathic or Pheromonal Lipids on the Body-Surface of Organisms.

    • Principal Investigator
      YAMASHITA Kyohei
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      製造化学・食品
    • Research Institution
      Tohoku University
  •  System for fluorometry of carboxylic acids under mild conditionPrincipal Investigator

    • Principal Investigator
      OHRUI Hiroshi
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B).
    • Research Field
      製造化学・食品
    • Research Institution
      TOHOKU UNIVERSITY
  •  糖蛋白質糖鎖の立体配座に関する研究

    • Principal Investigator
      目黒 煕
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用生物化学・栄養化学
    • Research Institution
      Tohoku University
  •  ホスフィンの特性を生かした螢光試薬の分子設計に関する研究Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      製造化学・食品
    • Research Institution
      Tohoku University
  •  Development of Micro Analytical System of Hydroperoxides in Lipids

    • Principal Investigator
      MEGURO Hiroshi
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B).
    • Research Field
      応用生物化学・栄養化学
    • Research Institution
      Tohoku University
  •  光学純度100%果実芳香成分マルメロラクトン,オキシド類の合成とその生理活性Principal Investigator

    • Principal Investigator
      大類 洋
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      製造化学・食品
    • Research Institution
      Tohoku University
  •  QUANTITATIVE REGIONAL MAPPING OF LIVER FUNCTION USING FLUORINATED POSITRON EMITTERS AND POSITRON EMISSION TOMOGRAPHY

    • Principal Investigator
      ITOH MASATOSHI
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      TOHOKU UNIVERSITY
  •  Development of new ultra micro analytical system based on the acridine fluorometry

    • Principal Investigator
      MEGURO Hiroshi
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      製造化学・食品
    • Research Institution
      TOHOKU UNIVERSITY
  •  環境試料中のSH,SS化合物及びSO⊆の簡易迅速分析法の開発に関する研究

    • Principal Investigator
      目黒 煕
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for Environmental Science
    • Research Institution
      Tohoku University

All 2007 2006 2005 2004

All Journal Article Book Patent

  • [Book] 耐性HIVが発現しない抗HIVヌクレオシド創製への挑戦2005

    • Author(s)
      大類 洋
    • Total Pages
      21
    • Publisher
      笹木出版印刷株式会社
    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] Selectivity Enhancement for trans-2-(2,3- Anthracendicarboximido)cyclohexane Derived Diastereomers in HPLC by using an Ordered Organic Stationary phase2007

    • Author(s)
      Atsushi Shundo, Megumi Fukui, Makoto Takafuji, Kazuaki Akasaka, Hiroshi Ohrui, Dusan Berek, Hirotaka Ihara
    • Journal Title

      Analytical Sciences 23

      Pages: 311-315

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16380076
  • [Journal Article] Creation of low toxic reverse-transcriptase inhibitory nucleosides that prevent the emergence of drug-resistant HIV variants2006

    • Author(s)
      Hiroshi Ohrui, Hiroyuki Hayakawa, Satoru Kohgo, Masao Matsuoka, Eiichi Kodama, Hiroaki Mitusya
    • Journal Title

      Yuki Gosei Kagaku Kyoukaishi 64

      Pages: 716-723

    • NAID

      10017617749

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] 2'-Deoxy-4'-C-Ethynyl-2-Fluoroadenosine, a Nucleoside Reverse Transcriptase Inhibitor, Is Highly Potent Against All Human Immunodeficiency Viruses Type a and Has Low Toxicity2006

    • Author(s)
      Hiroshi Ohrui
    • Journal Title

      The Chemical Record 6・3

      Pages: 133-143

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] 2'-Deoxy-4'-C-Ethynyl-2-Fluoroadenosine, a Nucleoside Reverse Transcriptase Inhibitor, Is Highly Potent Against All Human Immunodeficiency Viruses Type a and Has Low Toxicity2006

    • Author(s)
      Hiroshi Ohrui
    • Journal Title

      The Chemical Record 6-3

      Pages: 133-143

    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] Chiral Discrimination of Primary Amins by HPLC After Labeling with a Chiral Derivatization Reagent, trans-2-(2,3-Anthracenedicarboximido)cyclohexanecarbonyl Chloride2006

    • Author(s)
      Kazuaki Akasaka, Takashi Ohtaki, Hiroshi Ohrui
    • Journal Title

      J.Separation Science 29(10)

      Pages: 1390-1398

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16380076
  • [Journal Article] 耐性HIVを発現させない・高活性・低毒性・逆転写酵素阻害ヌクレオシドの創製研究2006

    • Author(s)
      大類 洋
    • Journal Title

      実用産業情報 -39

      Pages: 2-10

    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] Creation of low toxic and highly active reverse-transcriptase-inhibiting nucleosides which avoid the emergence of resistant HIV.2006

    • Author(s)
      Hiroshi Ohrui
    • Journal Title

      Jitsuyo Sangyo Jyoho 46

      Pages: 2-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] 耐性HIVを発現させない,低毒性・高活性の逆転写酵素阻害ヌクレオシドの創製2006

    • Author(s)
      大類 洋
    • Journal Title

      化学と生物 44-10

      Pages: 660-662

    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] 耐性HIVを発現させない,低毒性・高活性の逆転写酵素阻害ヌクレオシドの創製2006

    • Author(s)
      大類 洋
    • Journal Title

      化学と生物 44・10

      Pages: 660-662

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] Direct determination of the stereoisomers constitution by 2D-HPLC and stereochemistry-pheromone acitivity relationship of the copulation release pheromone of the cowpea weevil, Callosobruchus maculates2006

    • Author(s)
      Arata Yajima, Kazuaki Akasaka, Tomonori Bakai, Hiroki Maehara, Tomoo Nukada, Hiroshi Ohrui, Goro Yabuta
    • Journal Title

      Tetrahedron 62

      Pages: 4590-4596

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16380076
  • [Journal Article] Chiral Discrimination of Primary Amins by HPLC After Labeling with a Chiral Derivatization Reagent, trans-2-(2,3-Anthracenedicarbox- imido)cyclohexanecarbonyl Chloride2006

    • Author(s)
      Kazuaki Akasaka, Takashi Ohtaki, Hiroshi Ohrui
    • Journal Title

      Journal of Separation Science 29

      Pages: 1390-1398

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16380076
  • [Journal Article] Chiral Discrimination of Primary Amins by HPLC After Labeling with a Chiral Derivatization Reagent, trans-2-(2,3-Anthracenedicarbox-imido)cyclohexanecarbonyl Chloride2006

    • Author(s)
      Kazuaki Akasaka, Takashi Ohtaki, Hiroshi Ohrui
    • Journal Title

      Journal of Separation Science 29

      Pages: 1390-1398

    • Data Source
      KAKENHI-PROJECT-16380076
  • [Journal Article] 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine : A nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma2006

    • Author(s)
      Hiroshi Ohrui
    • Journal Title

      Nucleic Acids Symposium Series 50

      Pages: 1-2

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] 耐性HIVを発現させない低毒性逆転写酵素阻害ヌクレオシドの創製研究2006

    • Author(s)
      大類 洋
    • Journal Title

      有機合成化学協会誌 64・7

      Pages: 716-723

    • NAID

      10017617749

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity.2006

    • Author(s)
      Hiroshi Ohrui
    • Journal Title

      Chemical Record 6

      Pages: 133-143

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] 耐性HIVを発現させない・高活性・低毒性・逆転写酵素阻害ヌクレオシドの創製研究2006

    • Author(s)
      大類 洋
    • Journal Title

      実用産業情報 46

      Pages: 2-10

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] 耐性HIVを発現させない低毒性逆転写酵素阻害ヌクレオシドの創製成研究2006

    • Author(s)
      大類 洋
    • Journal Title

      有機合成化学協会誌 64-7

      Pages: 716-723

    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine : a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma.2006

    • Author(s)
      Hiroshi Ohrui, Satoru Kohgo, Hiroyuki Hayakawa, Eiichi Kodama, Masao Matsuoka, Tomohiro Nakata, Hiroyuki Mitsuya
    • Journal Title

      Nucleic acids symposium series 50

      Pages: 1-2

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine : A nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma2006

    • Author(s)
      Hiroshi Ohrui
    • Journal Title

      Nucleic Acids Symposium Series -50

      Pages: 1-2

    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] Creation of low toxic and highly active reverse-transcriptase-inhibiting nucleosides which avoid the emergence of resistant HIV. Can they be dream drugs for AIDS or hepatitis B.2006

    • Author(s)
      Hiroshi Ohrui
    • Journal Title

      Kagaku to Seibutsu 44

      Pages: 660-662

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380070
  • [Journal Article] Chiral Discrimination of secondary alcohols by both ^1H-NMR and HPLC after labeling with a chiral derivatization reagent, 2-(2,3-anthracenedi-carboximide)cyclohexane carboxylic Acid,2005

    • Author(s)
      Takashi Ohtaki, Kazuaki Akasaka, Chizuko Kabuto, Hiroshi Ohrui
    • Journal Title

      Chirality 17(S1)

      Pages: 171-176

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16380076
  • [Journal Article] Development of Highly Potent D-Glucosamine-Based Chiral Fluorescent Labeling Reagents and a Microwave-Assisted β-Selective Glycosidation of a Methyl Glycoside Reagent2005

    • Author(s)
      Hiroshi Ohrui, Kazuaki Akasaka, 他4名
    • Journal Title

      Bioscience, Biotechnology and Boichemistry 69・5

      Pages: 1054-1057

    • NAID

      130000030345

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16380076
  • [Journal Article] Development of Highly Potent D-Glucosamine-Based Chiral Fluorescent Labeling Reagents and a Microwave-Assisted beta-Selective Glycosidation of a Methyl Glycoside Reagent2005

    • Author(s)
      Hiroshi Ohrui, Kazuaki Akasaka, 他4名
    • Journal Title

      Bioscience, Biotechnology and Boichemistry 69・5

      Pages: 1054-1057

    • Data Source
      KAKENHI-PROJECT-16380076
  • [Journal Article] Crystalline structure of N-(S)-2-heptyl (1R,2R)-2-(2,3-anthracenedicarboximido)cyclohexanecarboxamide that differs from its preferred conformation in the solvent used for crystallization2005

    • Author(s)
      Kazuaki Akasaka, Takashi Ohtaki, Chizuko Kabuto, Takeshi Kitahara, Hiroshi Ohrui
    • Journal Title

      Bioscience, Biotechnology and Boichemistry 69(10)

      Pages: 2002-2004

    • NAID

      130000030540

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16380076
  • [Journal Article] Development of Highly Potent D-Glucosamine-Based Chiral Fluorescent Labeling Reagents and a Microwave-Assisted β-Selective Glycosidation of a Methyl Glycoside Reagent,2005

    • Author(s)
      Hiroshi Ohrui, Rumiko Katoh, Teruhisa Kodaira, Hiroki Shimizu, Kazuaki Akasaka, Takeshi Kitahara
    • Journal Title

      Bioscience, Biotechnology and Boichemistry 69(5)

      Pages: 1054-1057

    • NAID

      130000030345

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16380076
  • [Journal Article] Synthesis of four stereoisomers of 2,6-dimethyloctane-1,8-dioic acid, a component of the copulation release pheromone of the cowpea weevil, Callosobruchus maculates2005

    • Author(s)
      Tomonori Nakai, Arata Yajima, Kazuaki Akasaka, Takayuki Kaihoku, Miki Ohtaki, Tomoo Nukada, Hiroshi Ohrui, Goro Yabuta
    • Journal Title

      Bioscience, Biotechnology and Boichemistry 69(12)

      Pages: 2401-2408

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16380076
  • [Journal Article] Design, Efficient Synthesis, and Anti-HIV Activity of 4'-C-Cyano-and 4'-C-Ethynyl-2'-deoxy Purine Nucloesides2004

    • Author(s)
      S.Kohgo, K.Yamada, K.Kitano, Y.Iwai, S.Sakata, N.Ashida, H.Hayakawa, D.Nameki, E.Kodama, M.Matsuoka, H.Mitsuya, H.Ohrui
    • Journal Title

      NUCLEOSIDES, NUCLEOTIDES&NUCLEIC ACIDS 23・4

      Pages: 671-690

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14360062
  • [Journal Article] Design, Efficient Synthesis, and Anti-HIV Activity of 4'-C-Cyano- and 4'-C-Ethynyl-2'-deoxy Purine Nucloesides2004

    • Author(s)
      S.Kohgo, K.Yawada, K.Kitano, Y.Iwai, S.Sakata, N.Ashida, H.Hayakawa, D.Nameki, E.Kodama, M.Matsuoka, H.Mitsuya, H.Ohrui
    • Journal Title

      NUCLEOSIDES, NUCLEOTIDES&NUCLEIC ACIDS 23・4

      Pages: 671-690

    • Data Source
      KAKENHI-PROJECT-14360062
  • [Journal Article] Design, efficient Synthesis and Anti-HIV Activity of 4'-C-Cyano-and 4'-C-Ethynyl-2'-deoxy Purine Nucleosides2004

    • Author(s)
      S.Kohgo, K.Yamada, K.Kitano, Y.Iwai, S.Sakata, N.Ashida, H.Hayakawa, D.Nameki, E.Kodama, H.Mitsuya, H.Ohrui
    • Journal Title

      NUCLEOSIDES, NUCLEOTIDES&NUCLEIC ACIDS vol23,No4

      Pages: 671-690

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14360062
  • [Patent] 4'-C-置換-2-ハロアデノシン誘導体2005

    • Inventor(s)
      大類 洋 他
    • Industrial Property Rights Holder
      ヤマサ醤油株式会社
    • Filing Date
      2005-09-29
    • Data Source
      KAKENHI-PROJECT-17380070
  • 1.  NISHIDA Yoshihiro (80183896)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 0 results
  • 2.  AKASAKA Kazuaki (10201881)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 11 results
  • 3.  MEGURO Hiroshi (30005590)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 4.  TAKAHASHI Hiroaki
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  鈴木 建夫 (80005652)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  SATO Akira (20250764)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  YAMASHITA Kyohei (90005570)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MATSUDA Kazuhiro (00005662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  YASUMOTO Takeshi (20011885)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  IZAKI Kazuo (80005587)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  FUJIMORI Keisei (50238622)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  DOI Hideyuki (90188839)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KUWAHARA Shigefumi (30170145)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  ITOH MASATOSHI (00125501)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  MATSUZAWA TAIJU (10006108)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  FUKUDA HIROSHI (30125645)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  TADA MASAO (10006083)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  堀江 浩子 (40241559)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  佐竹 正博 (70147370)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  清水 弘樹 (30344716)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 21.  UMETSU Teruhiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  YAMAUCHI Yoshio
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  WADA Akio
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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